Zaltoprofen

製品コードS3008 バッチS300801

印刷

化学情報

Chemical Structure Synonyms CN100,Soleton Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C17H14O3S
分子量 298.36 CAS No. 74711-43-6
Solubility (25°C)* 体外 DMSO 60 mg/mL (201.09 mM)
Ethanol 31 mg/mL (103.9 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Zaltoprofen(CN100,Soleton) is an inhibitor of COX-1 and COX-2 for treatment of arthritis.
in vitro

Zaltoprofen binds to specific sites on the protein of the bradykinin B2 receptor, hence we have examined the effect of this compound on bradykinin-induced responses of adult DRG neurons to investigate possible interaction sites. It most potently inhibits bradykinin-enhancement of capsaicin-induced Ca2+ uptake into DRG neurons. This chemical also significantly inhibits bradykinin-induced 12-lipoxygenase (12-LOX) activity and the slow bradykinin-induced onset of substance P release from DRG neurons. [1] It produces an analgesic action on bradykinin-induced nociceptive responses by blocking the B(2) receptor-mediated pathway in the primary sensory neurons. This compound completely inhibits the bradykinin-induced increase of [Ca(2+)](i), which is inhibited by B(2) antagonist D-Arg-[Hyp(3), Thi(5,8), D-Phe(7)]-bradykinin, but not by B(1) antagonist. [2] It at 1nmol shows strong analgesic action on BK (i.pl.)-induced nociceptive flexor responses, whereas loxoprofen or its active metabolite loxoprofen-SRS does not. This chemical also inhibits the nociception induced by [Tyr8]-BK, a specific agonist of B2-type BK receptor, but does not affect the nociception by [Lys-des-Arg9]-BK, a specific agonist of B1-type BK receptor. [3] It is a non-steroidal anti-inflammatory drug (NSAID) causes potent inhibition of cyclooxygenase-2 with fewer side effects on the gastrointestinal tract.[4]
in vivo

Zaltoprofen improves the loss in body weight in both Con A-treated mice and carbon tetrachloride-treated rats. [4] This compound (10 mg/kg) administrated at 8 h after Con A treatment is found to inhibit the Con A-induced reduction in body weight. It (10 mg/kg) combined with Con A results in four times greater food intake than that in mice treated with only Con A. [5]

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/15857630/
  • https://pubmed.ncbi.nlm.nih.gov/16473424/
  • https://pubmed.ncbi.nlm.nih.gov/16406342/
  • https://pubmed.ncbi.nlm.nih.gov/11891529/
  • https://pubmed.ncbi.nlm.nih.gov/11494061/

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。