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シグナル伝達経路

研究分野

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1452 Ispinesib (SB-715992) <1 mg/mL 103 mg/mL 103 mg/mL
S2182 SB743921 HCl 22 mg/mL 111 mg/mL 111 mg/mL
S2731 AZ 3146 <1 mg/mL 28 mg/mL 91 mg/mL
S7090 GSK923295 <1 mg/mL 100 mg/mL 100 mg/mL
S7355 ARQ 621 <1 mg/mL 100 mg/mL 100 mg/mL
S5522 H-Cys(Trt)-OH -1 mg/mL 5 mg/mL -1 mg/mL
S8439 Monastrol <1 mg/mL 58 mg/mL 58 mg/mL
S8215 BAY 1217389 <1 mg/mL 100 mg/mL 3 mg/mL
S7488 MPI-0479605 <1 mg/mL 62 mg/mL 2 mg/mL
製品コード 製品説明 文献中の使用例 お客様のフィードバック
S1452

Ispinesib (SB-715992)

Ispinesib (SB-715992) is a potent, specific and reversible inhibitor of kinesin spindle protein (KSP) with Ki app of 1.7 nM in a cell-free assay, no inhibition to CENP-E, RabK6, MCAK, MKLP1, KHC or Kif1A. Phase 2.

S2182

SB743921 HCl

SB743921 is a kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM, almost no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E. Phase 1/2.

S2731

AZ 3146

AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit.

S7090

GSK923295

GSK923295 is a first-in-class, specific allosteric inhibitor of CENP-E kinesin motor ATPase with Ki of 3.2 nM, and less potent to mutant I182 and T183. Phase 1.

S7355

ARQ 621

ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.

S5522

H-Cys(Trt)-OH

H-Cys(Trt)-OH is a specific inhibitor of Eg5 that inhibits Eg5-driven microtubule sliding velocity in a reversible fashion with an IC50 of 500 nM.

S8439

Monastrol

Monastrol is a cell-permeable small molecule inhibitor of kinesin-5(KIF11) which is essential for maintaining separation of the half-spindles.

S8215

BAY 1217389

BAY 1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1) with IC50 values below 10 nmol/L while showing an excellent selectivity profile.

S7488

MPI-0479605

MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases.

Tags: KSP inhibition | Kinesin inhibition | Kinesin assay | Kinesin phosphorylation | Kinesin cancer | KSP inhibitors cancer | KSP inhibitor clinical trial | Kinesin inhibitors list | Kinesin inhibitor review