目录号 L2200


サイズ 価格(税別)  
100uL/well (10mM solution) JPY 922097.00
2x100uL/well (10mM solution) JPY 1353346.00





  • (B) qRT-PCR analysis and immunostaining of murine HSCs treated with GDC-0449 on culture days 4 through 7 (to inhibit SMO) or culture day 7 SMO-LoxP HSCs treated with adenoviral Cre on day 4 (to disrupt the Smo gene).

    Gastroenterology 2012 143, 1319-29. Vismodegib (GDC-0449) purchased from Selleck

    Hh signaling controls metabolic reprogramming during liver injury in vivo. Immunohistochemistry identifies cells expressing the M2 isozyme of PKM2, a specific marker of glycolytic activity, ( C) inhibited in aged MDR2 -/- mice by GDC-0449.

    Gastroenterology 2012 143, 1319-29. Vismodegib (GDC-0449) purchased from Selleck

  • J Clin Invest 2013 123(12), 5119-34. Doxazosin Mesylate purchased from Selleck

    RU-SKI 43 blocks Shh signaling. (a) RU-SKI 43 blocks Gli activation. NIH 3T3 cells were cotransfected with vectors encoding 8× Gli-binding site (GliBS)-Firefly luciferase (unless indicated otherwise), Renilla luciferase reporter (pRL-TK) and Shh. Confluent cells were treated with DMSO, 10 μM LDE225, 10 μM RU-SKI 43 or 10 μM C-2. The firefly luciferase (FL)/Renilla luciferase (RL) ratio in cell lysates was calculated and normalized to that measured in DMSO-treated samples; error bars represent mean ± s.d. (n = 2–3). 

    Nat Chem Biol 2013 9, 247-9. Sonidegib (Erismodegib, NVP-LDE225) purchased from Selleck

  • PTPH1 confers breast cancer cell sensitivity to fulvestrant. E and F, PTPH1 overexpression increases the growth inhibition by fulvestrant. PTPH1 was overexpressed by a Tet-on system or a stable transfection, and resultant cells were incubated with fulvestrant as indicated for about 2 weeks. Colony formed was stained and counted. Results shown are normalized to its own solvent control of Vector and PTPH1-overexpressed cells, respectively (means ± SD; n = 3–5) with insets showing PTPH1 overexpression. *, versus vector or no Tet cells for E and F.

    Mol Cancer Ther 2014 13(1), 230-8. Fulvestrant purchased from Selleck

    J Med Chem 2014 57(3), 632-41. Raloxifene HCl purchased from Selleck

  • J Med Chem 2014 57(3), 632-41. Bazedoxifene HCl purchased from Selleck

    Eur J Cancer 2014 50(7), 1310-20. Forskolin purchased from Selleck

  • Western blot analysis on total cell lysates from renal cancer cell lines treated with NVP-LDE225 at different concentrations. Densitometric measurements were normalised to b-actin and reported under western blot images.

    Br J Cancer 2014 111(6), 1168-79. Sonidegib (Erismodegib, NVP-LDE225) purchased from Selleck

    The effects of a GPRC6A inhibitor on testosterone-induced ROS generation. Cells were pretreated with the GPRC6A inhibitor, NPS2143 (1 uM), for 30 min and ROS generation was monitored after 5 min of testosterone treatment. Data are presented as mean ?S.E. (n = 4).

    J Biol Chem 2014 289(42), 28835-45. NPS-2143 purchased from Selleck


• 482種類Gタンパク質共役受容体小分子の集めは製薬および生物技術会社の各項目研究とと薬剤開発プロジェクトにおいて、GPCR選別に使用します。
• GPCRの小分子化合物ライブラリーのすべての小分子は、良い生物と薬学活性を持っています。
• GPCR薬物は最も豊かな信号受体だと発見する道具です。
• およそ200個、いわゆる「O GPCRs (Orphan GPCRs)」は機能が知られていないから、弊社のGPCR化合物庫を使用することで、機能的が未知されないGPCRsを選別するときに、新しいGPCRベースの候補薬が起こる恐れがあります。
• GPCRの小分子化合物ライブラリーは、受容体と関係がある小分子(5-HT受容体、ドーパミン受容体、オピオイド受容体、アドレナリン受容体、カンナビノイド受容体、mGluRとETA―受容体等)を含めます。
• 構造多様で、効果が目立って、細胞浸透可。
• 十分に詳しい構造説明、,IC50値とお客様からフィードバックした資料があります。
• NMRとHPLC技術で製品の高純度を保証します。


調合: 482種類GPCR小分子は予めDMSO溶液に溶解します。
96穴板: 96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
安定性: in DMSO
出荷方式: ブルーアイス物流
包装: 不活性ガス(Inert gas)


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