GPCR Compound Library

目录号 L2200

サイズ 価格(税別)  
予めDMSOに溶解しています
100uL/well (10mM solution) JPY 950826.52
2x100uL/well (10mM solution) JPY 1395516.55
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お気に入りの分子或いは調達サービスにより、分子ライブラリーをカスタマイズします。
お客様自身のニーズを満たすために、弊社の製品を数量、状態(乾燥状態/固体或いはDMSO)等で選択できます。

GPCR Compound Library内容

お客様叙述(10)

  • (B) qRT-PCR analysis and immunostaining of murine HSCs treated with GDC-0449 on culture days 4 through 7 (to inhibit SMO) or culture day 7 SMO-LoxP HSCs treated with adenoviral Cre on day 4 (to disrupt the Smo gene).

    Gastroenterology 2012 143, 1319-29. Vismodegib (GDC-0449) purchased from Selleck

    Hh signaling controls metabolic reprogramming during liver injury in vivo. Immunohistochemistry identifies cells expressing the M2 isozyme of PKM2, a specific marker of glycolytic activity, ( C) inhibited in aged MDR2 -/- mice by GDC-0449.

    Gastroenterology 2012 143, 1319-29. Vismodegib (GDC-0449) purchased from Selleck

  • RU-SKI 43 blocks Shh signaling. (a) RU-SKI 43 blocks Gli activation. NIH 3T3 cells were cotransfected with vectors encoding 8× Gli-binding site (GliBS)-Firefly luciferase (unless indicated otherwise), Renilla luciferase reporter (pRL-TK) and Shh. Confluent cells were treated with DMSO, 10 μM LDE225, 10 μM RU-SKI 43 or 10 μM C-2. The firefly luciferase (FL)/Renilla luciferase (RL) ratio in cell lysates was calculated and normalized to that measured in DMSO-treated samples; error bars represent mean ± s.d. (n = 2–3). 

    Nat Chem Biol 2013 9, 247-9. Sonidegib (Erismodegib, NVP-LDE225) purchased from Selleck

    PTPH1 confers breast cancer cell sensitivity to fulvestrant. E and F, PTPH1 overexpression increases the growth inhibition by fulvestrant. PTPH1 was overexpressed by a Tet-on system or a stable transfection, and resultant cells were incubated with fulvestrant as indicated for about 2 weeks. Colony formed was stained and counted. Results shown are normalized to its own solvent control of Vector and PTPH1-overexpressed cells, respectively (means ± SD; n = 3–5) with insets showing PTPH1 overexpression. *, versus vector or no Tet cells for E and F.

    Mol Cancer Ther 2014 13(1), 230-8. Fulvestrant purchased from Selleck

  • J Med Chem 2014 57(3), 632-41. Raloxifene HCl purchased from Selleck

    J Med Chem 2014 57(3), 632-41. Bazedoxifene HCl purchased from Selleck

  • Eur J Cancer 2014 50(7), 1310-20. Forskolin purchased from Selleck

    Western blot analysis on total cell lysates from renal cancer cell lines treated with NVP-LDE225 at different concentrations. Densitometric measurements were normalised to b-actin and reported under western blot images.

    Br J Cancer 2014 111(6), 1168-79. Sonidegib (Erismodegib, NVP-LDE225) purchased from Selleck

  • The effects of a GPRC6A inhibitor on testosterone-induced ROS generation. Cells were pretreated with the GPRC6A inhibitor, NPS2143 (1 uM), for 30 min and ROS generation was monitored after 5 min of testosterone treatment. Data are presented as mean ?S.E. (n = 4).

    J Biol Chem 2014 289(42), 28835-45. NPS-2143 purchased from Selleck

    Myogenic differentiation assay to determine the GR specificity of DEX by using RU-486 (10 uM). Immunofluorescence detection of MyHC (red) and DAPI counterstaining of nuclei (blue) was used to detect myotubes. The scale bar is 50 um.

    PLoS One 2014 9(8), e105528. Mifepristone purchased from Selleck

製品特性&メリット

・Gタンパク質共役受容体をターゲットとした497種類の化合物ライブラリーです。HTS(High Throughput Screening) およびHCS(High Content Screening)に使用できます。

・ライブラリーの化合物は全て生物活性と薬理活性を有しています。

・オーファンGPCR(Orphan GPCR)は機能未知なため、弊社のGPCR化合物ライブラリーを使用することで機能未知のGPCRsを選別し、新たなGPCR標的薬を見出す可能性があります。

・GPCR化合物ライブラリーは様々な受容体(5-HT受容体、ドーパミン受容体、オピオイド受容体、アドレナリン受容体、カンナビノイド受容体、代謝型グルタミン酸受容体、エンドセリン受容体など)を標的としています。

・構造的に多様で、薬効および細胞透過性が確認されています。

・詳しい構造説明と、お客様からのレビューなど豊富な情報があります。

・NMRとHPLC検査で製品の高純度を保証しています。

製品詳細情報

調合: 497種類GPCR小分子は予めDMSO溶液に溶解します。
96well: 96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
安定性: in DMSO
in DMSO
出荷方式: ブルーアイス物流
包装: 不活性ガス(Inert gas)

GPCR Compound Library製品説明

HTS パートナ

他のライブラリー