プロテアーゼ阻害剤ライブラリー

目录号 L2500

53種プロテアーゼ阻害剤の集め

サイズ 価格(税別)  
予めDMSOに溶解します
100uL/well (10mM solution) JPY 292824.00
2x100uL/well (10mM solution) JPY 460152.00
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お気に入りの分子或いは調達サービスにより、分子ライブラリーをカスタマイズします。
お客様自分の特別なニーズに満たすために、お客様は弊社の製品を数量、状態(乾燥状態/固体或いはDMSO)等で選択できます。

プロテアーゼ阻害剤ライブラリー内容

セレック分子ライブラリーは文献で引用されること(1)

お客様叙述(10)

  • Effect of different proteasome inhibitors on dysferlin expression and on membrane resealing in cultured primary myoblasts. Primary myoblasts from patient 2 harboring a homozygous Arg555Trp DYSF mutation that were treated with the indicated amounts of bortezomib for 24 hours. Western blots of protein extracts were stained with anti-dysferlin antibodies and with anti–a-tubulin antibody as loading control.

    Sci Transl Med 2015 6(250), 250ra112. Bortezomib (PS-341) purchased from Selleck

    Validation of activity and specificity of chemical inhibitors of; ATM, ATR, and DNAPK. H460 cells were treated with 1 uM camptothecin (CPT) or 20 ug/ml bleomycin for 1 h in the presence of the indicated inhibitors: DNAPK-i1—NU7026, DNAPK-i2—NU7441. MSH6,

    Sci Transl Med 2014 6(250), 250ra112. Carfilzomib (PR-171) purchased from Selleck

  • Primary myoblasts from patient 2 harboring a homozygous Arg555Trp DYSF mutation that were treated with the indicated amounts of MLN2238 for 24 hours.

    Sci Transl Med 2014 6(250), 250ra112. Ixazomib (MLN2238) purchased from Selleck

    Pharmacologic inhibition of the proteasome blocks proplatelet formation in murine and human megakaryocytes. Human megakaryocytes were pretreated with vehicle or bortezomib, and megakaryocytes producing proplatelets (PP) were examined. Shown are representative transmission images and representative confocal images with wheat germ agglutinin (WGA; red) and phalloidin (green) staining. Scale bars: 50 um.

    J Clin Invest 2014 124(9), 3757-66. Bortezomib (PS-341) purchased from Selleck

  • Primary myeloma cells were treated with DMSO or ritonavir for 72 hours before annexin V/DAPI staining. Values are normalized to DMSO-treated samples (n=1 for each patient sample).

    Blood 2012 119, 4686-97. Ritonavir purchased from Selleck

    (A) KMS11 and (B) L363 cells were plated in 5mM glucose medium with ritonavir or DMSO (D) for 17 hours. Glucose consumption rates are normalized to untreated cells (not shown). (C) KMS11 and (D) L363 cells were treated with ritonavir or DMSO for 72 hours. Relative viable cell numbers were determined by MTS assay and normalized to untreated cells (not shown).

    Blood 2012 119, 4686-97. Ritonavir purchased from Selleck

  • MM.1S cells were treated with or without carfilzomib (10 nM) in the presence or absence of TAS-117 (0.5 uM) for 24 h. Whole cell lysates were subjected to western blotting using CHOP, PARP, and GAPDH Abs.The graph represents fold changes of CHOP density relative to GAPDH.

    Cancer Res 2014 74(16), 4458-69. Carfilzomib (PR-171) purchased from Selleck

    Western blot analysis of HCV NS3 protease cleavage of MAVS. The catalytic efficiency of four proteases (H, H-A156T, 41 and 41-A156T) from individuals H and 41 were tested in the absence or presence of an NS3 protease inhibitor (danoprevir). Expression of the HCV NS3 proteases resulted in cleavage of the lambda cI repressor with MAVS cleavage site. Expression of the protease was induced with IPTG for 3 h. The lambda cI repressor with MAVS cleavage site was not cleaved by an NS3 protease that included a substitution in catalytic residue S139A. Similarly, different catalytic efficiencies were observed with different proteases.

    Mol Biol Evol 2014 31(6), 1546-53. Danoprevir (ITMN-191) purchased from Selleck

  • Western blotting showing increased unconjugated SUMO1 levels in Notch1 ΔE cells treated with 10 uM DAPT for 3 days. Tubulin was used as a loading control.

    Oncogene 2014 10.1038/onc.2014.319. DAPT (GSI-IX) purchased from Selleck

    A panel of GICs was treated with the indicated doses of DAPT for 48 hours. γSecretase inhibitors inhibited expression of NICD, Hes1, Hes3, and Hes5 in a dose-dependent manner.

    Stem Cells 2014 32(1), 301-12. DAPT (GSI-IX) purchased from Selleck

製品特性&メリット

•53種小分子阻害剤の集めは化学のゲノミクス、HTSとHCS (high content screening) に使用できます。
• 前期臨床研究と臨床試験を通じて、生物活性と安全性が検証されました
• プロテアソーム、HCVプロテアーゼ、DPP-4、カスペース、MMP、Yセレクターゼ(Gamma-secretase)とβアミロイドターゲットを目標にします。
• 構造多様で、効果が目立って、細胞浸透可です。
• 十分に詳しい構造説明とお客様からフィードバックした資料があります。
• NMRとHPLC技術で製品の高純度を保証します。

製品詳細情報

調合: 53種プロテアーゼ阻害剤の集めは予めDMSO溶液に溶解します。
96穴板: 96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
安定性: in DMSO
in DMSO
出荷方式: ブルーアイス物流
包装: 不活性ガス(Inert gas)

プロテアーゼ阻害剤ライブラリー製品説明

HTS パートナ

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