Anti-diabetic Compound Library

目录号 L2900

サイズ 価格(税別)  
予めDMSOに溶解しています
100uL/well (10mM solution) JPY 136397.00
2x100uL/well (10mM solution) JPY 197374.00
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お気に入りの分子或いは調達サービスにより、分子ライブラリーをカスタマイズします。
お客様自身のニーズを満たすために、弊社の製品を数量、状態(乾燥状態/固体或いはDMSO)等で選択できます。

Anti-diabetic Compound Library内容

セレックの分子ライブラリーが使用されている文献(2)

お客様叙述(10)

  • Effect of rosiglitazone (RSG) treatment on neutrophil shift toward an N2 phenotype.Representative photomicrographs showing Ym1 (green) and neutrophils (red) double immunostaining 24 (upper) and 48 hours (lower) after permanent middle cerebral artery occlusion (pMCAO) in vehicle (VEH)- or RSG-treated mice.

    Stroke 2013 44(12), 3498-508. Rosiglitazone maleate purchased from Selleck

    For anchorage dependent clonogenic assays, HER2+ breast cancer BT474 cells were seeded at low density in 6-well plates and allowed to adhere overnight. The next day, olaparib and rucaparib were added at the indicated concentrations. Media and drugs were replenished every three days. After 10-15 days, depending on cell proliferation rate, cells were fixed and stained with crystal violet. Images and graphs indicate the results compared to control condition. Data are mean ± S.D. n.s.: non-significant, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.

    Eur J Cancer 2014 50(15), 2725-34. Rucaparib (AG-014699,PF-01367338) phosphate purchased from Selleck

  • Total cell extracts of BT-474 cells treated with increasing concentrations of olaparib or rucaparib were subjected to western blot analysis for PARP-1 and poly ADP-ribose (PAR) expression. β-tubulin was used as loading control. Representative images from two separate experiments are shown.

    Eur J Cancer 2014 50(15), 2725-34. Rucaparib (AG-014699,PF-01367338) phosphate purchased from Selleck

    INS-1 cells were incubated with 50 uM palmitate or BSA in the presence or absence of 5 uM TAK 875 for 30 min, followed by stimulation with 16.6 mm [U-13C]glucose for 30 min. Under these conditions, the following were measured: fructose bisphosphate (FBP) (I), NADH/NAD+ ratio (J). Error bars represent mean ?S.E. n = 3-4.

    J Biol Chem 2014 289(19), 13575-88. Fasiglifam (TAK-875) purchased from Selleck

  • J Leukoc Biol 2014 95(4), 587-98. Rosiglitazone purchased from Selleck

    J Leukoc Biol 2014 95(4), 587-98. Rosiglitazone purchased from Selleck

  • J Leukoc Biol 2014 95(4), 587-98. Rosiglitazone HCl purchased from Selleck

    J Leukoc Biol 2014 95(4), 587-98. Rosiglitazone HCl purchased from Selleck

  • Total and phosphorylated Akt were detected by western blot in protein lysates of liver, inguinal WAT and gastrocnemius muscle from mice that were treated with an insulin bolus after an overnight fast.

    Mol Metab 2013 2(3), 215-26. Rosiglitazone maleate purchased from Selleck

    The selective GPR40 agonist, TAK- 875, also has a selective inhibitory effect on the growth of all three human melanoma cell lines tested without negatively effecting the growth of the control fibroblast or human breast cancer cell lines even at very high concentrations.

    J Surg Res 2014 188(2):451-8. Fasiglifam (TAK-875) purchased from Selleck

製品特性&メリット

・糖尿病の発症に影響を及ぼす29種類の低分子ライブラリーです。

・Ⅰ型およびⅡ型糖尿病モジュレーター(DPP-4、GPR、K+チャネル、PPAR、SGLTなど)を標的にしています。

・構造的に多様で、薬効および細胞透過性が確認されています。

・詳しい構造説明と、お客様からのレビューなど豊富な情報があります。

・NMRとHPLC検査で製品の高純度を保証しています。

製品詳細情報

調合: 29種抗糖尿病(Anti- diabetic)化合物の集めは予めDMSO溶液に溶解します。
96well: 96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
安定性: in DMSO
in DMSO
出荷方式: ブルーアイス物流
包装: 不活性ガス(Inert gas)

Anti-diabetic Compound Library製品説明

HTS パートナ

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