抗感染(Anti-infection)化合物ライブラリー

目录号 L3100

臨床実験に於く142種抗感染(Anti-infection)化合物の集め

サイズ 価格(税別)  
予めDMSOに溶解します
100uL/well (10mM solution) JPY 612872.00
2x100uL/well (10mM solution) JPY 919308.00
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お気に入りの分子或いは調達サービスにより、分子ライブラリーをカスタマイズします。
お客様自分の特別なニーズに満たすために、お客様は弊社の製品を数量、状態(乾燥状態/固体或いはDMSO)等で選択できます。

抗感染(Anti-infection)化合物ライブラリー内容

セレック分子ライブラリーは文献で引用されること(1)

お客様叙述(10)

  • (A) KMS11 and (B) L363 cells were plated in 5mM glucose medium with ritonavir or DMSO (D) for 17 hours. Glucose consumption rates are normalized to untreated cells (not shown). (C) KMS11 and (D) L363 cells were treated with ritonavir or DMSO for 72 hours. Relative viable cell numbers were determined by MTS assay and normalized to untreated cells (not shown).

    Blood 2012 119, 4686-97. Ritonavir purchased from Selleck

    Primary myeloma cells were treated with DMSO or ritonavir for 72 hours before annexin V/DAPI staining. Values are normalized to DMSO-treated samples (n=1 for each patient sample).

    Blood 2012 119, 4686-97. Ritonavir purchased from Selleck

  • CCR5 antagonists block FBS-induced breast cancer cell invasion. 3D reconstruction of FBS-induced invasion into collagen gels by Hs578T (A) or SUM-159 (C) breast cancer cells in presence of CCR5 antagonists (100 nmol/L). The corresponding quantifications (mean ±SEM, n = 3) and analysis (Bonferronit test) are displayed in B and D.

    Cancer Res 2012 72(15), 3839-50. Maraviroc purchased from Selleck

    Ciprofoxacin (Cipro) reduces cancer cell survival in combination with chemotherapy. A and B, colony formation was conducted with A549 and SW48 cells treated with the clinically relevant chemotherapeutics cisplatin or 5-FU in the presence or absence of 2 μmol/L cipro floxacin. C, cipro fl oxacin at 2 μmol/L decreased proliferation of KG-1 cells and slightly enhanced the effect of etoposide (Etop). *, P < 0.05; **, P < 0.01 ( t tests).

    Cancer Res 2012 72(23), 6200-8. Ciprofloxacin purchased from Selleck

  • J Med Chem 2014 57(3), 632-41. Bazedoxifene HCl purchased from Selleck

    Effect of antiretrovirals and positive control rifampicin (at 10 μmol/L) on ABCB1 function in LS180 cells after 3 and 7 days (d) of treatment. ABCB1 function was normalized to the medium control. Data are expressed as means+SEM for n¼4. **P<0.01.

    J Antimicrob Chemother 2011 66, 802-812. Elvitegravir (GS-9137, JTK-303) purchased from Selleck

  • PhA efflux in MDCKII-BCRP cells. Concentration-dependent inhibition of BCRP/ABCG2 by elvitegravir and vicriviroc. Each curve depicts one representative experiment of a series of three or four; each concentration was tested in 30000 cells.

     

     

    J Antimicrob Chemother 2011 66, 802-812. Elvitegravir (GS-9137, JTK-303) purchased from Selleck

    Strand transfer was carried out with RSV IN(1-269) (4 uM) and GU320R(2 uM)in the presence of 50mM NDSB201. Increasing concentrations of STIs were added as indicated at the top; DTG(Dolutegravir) in lanes 3-5, MK-2048 in lanes 6-8, and RAL in lanes 9-11. No STI was present in lane 2, and lane 1 contains the molecular weight markers. Strand transfer products and ODN substrate are identified on the right. CHS, circular half-site; OC target and SC target, open circular and supercoiled target DNA, respectively.

    J Biol Chem 2014 289(28), 19648-58. Dolutegravir (GSK1349572) purchased from Selleck

  • Low-micromolar amounts of chloroquine, chlorpromazine, loperamide, and lopinavir inhibit MERS-CoV-induced cytopathology. Huh7 cells in 96-well plates were infected with MERS-CoV isolate EMC/2012 (MOI, 0.005) in the presence of 0 to 20 uM LPV. Cells were incubated for 2 days, and cell viability was monitored using an MTS assay. In addition, the potential toxicity of compound treatment only was monitored in parallel mock-infected Huh7 cell cultures. Graphs show the results (averages and standard deviations [SD]) of a representative experiment that was performed in quadruplicate. All experiments were repeated at least twice. For each compound, the calculated EC50, CC50, and SI values are given.

    Antimicrob Agents Chemother 2014 58(8), 4875-84. Lopinavir purchased from Selleck

    HCV replicon genotype 1b cells were passaged in the presence of G418 alone (medium 694 control) or G418 with miravirsen, SPC4729 (oligonucleotide negative control) or telaprevir for 28 days in fixed concentrations at a multiple (X) of the EC50 of miravirsen or telaprevir. Colony formation was assessed by staining surviving cells with crystal violet.

    Antimicrob Agents Chemother 2014 10.1128/AAC.04220-14. Telaprevir (VX-950) purchased from Selleck

製品特性&メリット

• 生物活性を持っている抗生学(antibiotics)、抗真菌薬(antifungal drugs)、抗HIV等の142種抗感染(Anti-infection)小分子の集めです。
• このライブラリーの化合物は主にスルホンアミド( sulfonamide)、アミノグリコシド(aminoglycoside)、テトラサイクリン(tetracycline)とマクロライド(macrolide)を含めます。
• 学術研究機関、医学研究組織と製薬工業に於いて感染病を研究するよい道具です。
• 構造多様で、効果が目立って、細胞浸透可です。
• 十分に詳しい構造説明とお客様からフィードバックした資料があります。
• NMRとHPLC技術で製品の高純度を保証します。

製品詳細情報

調合: 142種抗感染(Anti-infection)化合物の集めは予めDMSO溶液に溶解します。
96穴板: 96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
安定性: in DMSO
in DMSO
出荷方式: ブルーアイス物流
包装: 不活性ガス(Inert gas)

抗感染(Anti-infection)化合物ライブラリー製品説明

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