幹細胞の小分子化合物ライブラリー

目录号 L2100

88種類の幹細胞小分子化合物の集め

サイズ 価格(税別)  
予めDMSOに溶解します
100uL/well (10mM solution) JPY 483392.00
2x100uL/well (10mM solution) JPY 756960.00
ご連絡ください

お気に入りの分子或いは調達サービスにより、分子ライブラリーをカスタマイズします。
お客様自分の特別なニーズに満たすために、お客様は弊社の製品を数量、状態(乾燥状態/固体或いはDMSO)等で選択できます。

幹細胞の小分子化合物ライブラリー内容

セレック分子ライブラリーは文献で引用されること(2)

お客様叙述(10)

  • Effects of CP-690550 on NKTCL cell lines. NK-S1, KHYG-1 cells were treated with CP-690550 for 48 hours, and the effect on STAT5 phosphorylation was evaluated by Western blotting.

    Cancer Discov 2012 2(7), 591-7. Tofacitinib (CP-690550,Tasocitinib) purchased from Selleck

    (B) qRT-PCR analysis and immunostaining of murine HSCs treated with GDC-0449 on culture days 4 through 7 (to inhibit SMO) or culture day 7 SMO-LoxP HSCs treated with adenoviral Cre on day 4 (to disrupt the Smo gene).

    Gastroenterology 2012 143, 1319-29. Vismodegib (GDC-0449) purchased from Selleck

  • Hh signaling controls metabolic reprogramming during liver injury in vivo. Immunohistochemistry identifies cells expressing the M2 isozyme of PKM2, a specific marker of glycolytic activity, ( C) inhibited in aged MDR2 -/- mice by GDC-0449.

    Gastroenterology 2012 143, 1319-29. Vismodegib (GDC-0449) purchased from Selleck

    The ROCK inhibitors fasudil and Y27632 prevented SCP2 cell bone metastasis in nude mice (n = 10 per group). Shown are BLI images of bone metastases, IHC analyses of SMAD3 C-tail phosphorylation and PTHLH, osteoclast TRAP staining, and BLI quantitation.

    J Clin Invest 2014 124(4), 1646-59. Fasudil (HA-1077) HCl purchased from Selleck

  • Tamoxifen was administered to adult Psmc1fl/wt and Psmc1fl/fl Pdgf-Cre-ER mice, followed by treatment with fasudil control (4 and 48 hours after tamoxifen). Representative images of Dylight 488-positive megakaryocytes present in crude bone marrow isolated from Psmc1fl/wt and Psmc1fl/flPdgf-Cre-ER mice immediately after euthanasia. Bone marrow for these studies was isolated from a subset of the mice in A (n=2 per treatment group). Scale bars: 100 um.

    J Clin Invest 2014 124(9), 3757-66. Fasudil (HA-1077) HCl purchased from Selleck

    IL-6- supported INA-6 cells were treated with the JAK inhibitors ruxolitinib (Rux; 10 nM) or CYT387 (CYT; 50 nM) for 1 hour and assessed for inhibition of STAT3 phosphorylation by immunoblotting.

    J Clin Invest 2014 10.1172/JCI69094. Momelotinib (CYT387) purchased from Selleck

  • RU-SKI 43 blocks Shh signaling. (a) RU-SKI 43 blocks Gli activation. NIH 3T3 cells were cotransfected with vectors encoding 8× Gli-binding site (GliBS)-Firefly luciferase (unless indicated otherwise), Renilla luciferase reporter (pRL-TK) and Shh. Confluent cells were treated with DMSO, 10 μM LDE225, 10 μM RU-SKI 43 or 10 μM C-2. The firefly luciferase (FL)/Renilla luciferase (RL) ratio in cell lysates was calculated and normalized to that measured in DMSO-treated samples; error bars represent mean ± s.d. (n = 2–3). 

    Nat Chem Biol 2013 9, 247-9. Sonidegib (Erismodegib, NVP-LDE225) purchased from Selleck

    Fluorescence microscopy of pSuper or Cdo shRNA expressing P19 cells at ITS1 immunostained withβ-tubulin III antibodies. Size bar=100 um. P19/control or P19/Cdo shRNA cells were treated with DMSO or XAV939 in the differentiation medium for 72 h followed by immunostaining.

    Nat Commun 2014 5, 5455. XAV-939 purchased from Selleck

  • STAT3 phosphorylation as determined by phospho flow, mixed lymphocyte reactions containing BALB/c spleen-derived CD4+ T cells co-cultured with or without C57BL/6 BM-derived DC preactivated with 20 ng/mL LPS.

    Blood 2014 123(24), 3832-42. Ruxolitinib (INCB018424) purchased from Selleck

    Colony-forming assay results showing that the Jak2 inhibitor TG101348 reduces CFU-GM colonies generated from mutant fetal liver R2 cells. Results from 4 independent control or mutant fetal livers treated with TG101348 or dimethylsulfoxide (DMSO) are shown (mean ?SD). ***P < .001.

    Blood 2014 123(20), 3175-84. Fedratinib (SAR302503, TG101348) purchased from Selleck

製品特性&メリット

• 生物活性を持っている88種類の小分子化合物の集めは幹細胞調整と信号経路研究に使用できます。幹細胞庫の中のすべての小分子阻害剤は良い生物と薬学活性を持っています。
• 腫瘤幹細胞によって、幹細胞再生治療方法、薬物選別機能と他の生物応用に研究する一つ道具です。
• 幹細胞阻害剤庫は幹細胞功能を調整する信号経路と関係する小分子(例えば、Wnt、Notch、 SMADとHedgehog 信号)を含めます。
• 構造多様で、効果が目立って、細胞浸透可。
• 十分に詳しい構造説明とお客様からフィードバックした資料があります。
• NMRとHPLC技術で製品の高純度を保証します。

製品詳細情報

調合: 88種類の幹細胞小分子は予めDMSO溶液に溶解します。
96穴板: 96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
安定性: in DMSO
in DMSO
出荷方式: ブルーアイス物流
包装: 不活性ガス(Inert gas)

幹細胞の小分子化合物ライブラリー製品説明

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