PPAR

信号経路図

研究分野

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S2505 Rosiglitazone maleate <1 mg/mL 94 mg/mL <1 mg/mL
S2556 Rosiglitazone <1 mg/mL 71 mg/mL <1 mg/mL
S2915 GW9662 <1 mg/mL 55 mg/mL <1 mg/mL
S2871 T0070907 <1 mg/mL 26 mg/mL <1 mg/mL
S2590 Pioglitazone <1 mg/mL 10 mg/mL <1 mg/mL
S8432 Troglitazone (CS-045) <1 mg/mL 88 mg/mL 15 mg/mL
S8029 WY-14643 (Pirinixic Acid) <1 mg/mL 64 mg/mL 52 mg/mL
S8025 GSK3787 <1 mg/mL 79 mg/mL <1 mg/mL
S8020 GW0742 <1 mg/mL 94 mg/mL 44 mg/mL
S1729 Gemfibrozil <1 mg/mL 50 mg/mL 50 mg/mL
S2665 Ciprofibrate <1 mg/mL 58 mg/mL 58 mg/mL
S4159 Bezafibrate <1 mg/mL 72 mg/mL 18 mg/mL
S4207 Clofibric Acid <1 mg/mL 43 mg/mL 43 mg/mL
S1794 Fenofibrate <1 mg/mL 72 mg/mL 46 mg/mL
S2075 Rosiglitazone HCl <1 mg/mL 79 mg/mL 79 mg/mL
S7767 AZ6102 <1 mg/mL 85 mg/mL <1 mg/mL
S7484 FH535 <1 mg/mL 72 mg/mL <1 mg/mL
S4527 Fenofibric acid 63 mg/mL 63 mg/mL 63 mg/mL
S4708 Palmitoylethanolamide <1 mg/mL 59 mg/mL 59 mg/mL

亜型選択性的な製品

製品コード 製品説明 文献中の使用例 お客様のフィードバック
S2505

Rosiglitazone maleate

Rosiglitazone maleate is an anti-diabetic agent in the thiazolidinedione class of agents.

S2556

Rosiglitazone

Rosiglitazone is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively.

S2915

GW9662

GW9662は選択的なPPAR敵対者、PPARγ、 PPARαと PPARδを妨げて、IC50 がそれぞれ 3.3 nM、 32 nM と 2 μMです。

S2871

T0070907

T0070907 is a potent and selective PPARγ inhibitor with IC50 of 1 nM, with a >800-fold selectivity over PPARα and PPARδ.

S2590

Pioglitazone

Pioglitazone (Actos) is a selective peroxisome proliferator-activated receptor gamma stimulator.

S8432

Troglitazone (CS-045)

S8029

WY-14643 (Pirinixic Acid)

WY-14643 (Pirinixic Acid) は強力なペルオキシソーム増殖とPPARαの活性化因子です。

S8025

GSK3787

GSK3787は、 PPARδの強力で選択的な拮抗剤、pIC50 が 6.6です。

S8020

GW0742

GW0742は、強力で非常に選択的なPPAR β/δ 作用薬で、hPPARδへの装丁IC50 が 1 nMです。

S1729

Gemfibrozil

Gemfibrozil (Lopid) is a compound used to lower lipid levels.

S2665

Ciprofibrate

Ciprofibrate is a peroxisome proliferator-activated receptor agonist.

S4159

Bezafibrate

Bezafibrate is the first clinically tested dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism.

S4207

Clofibric Acid

Clofibric acid is a PPARα agonist and hypolipidemic agent.

S1794

Fenofibrate

Fenofibrate (Tricor, Trilipix) is a compound of the fibrate class and fibric acid derivative.

S2075

Rosiglitazone HCl

Rosiglitazone HCl is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.

S7767

AZ6102

AZ6102は1種の有効なTNKS1/2阻害剤です。セレクティブについて、他のDNA家族酵素より100倍が高くなります。DLD-1細胞でAZ6102はWnt信号経路を抑制します(IC50値:5 nM)。

S7484

FH535

FH535は1種のWnt/β-catenin信号伝導阻害剤で、同時に、PPARγとPPARδの二重拮抗剤です。

S4527

Fenofibric acid

Fenofibric acidは1種のフィブラート(fibrate)で、低密度リポタンパク質コレステロール(low-density lipoprotein cholesterol)とトリグリセリド(triglycerides)を下げます。

S4708

Palmitoylethanolamide