SF1670 is a highly potent and specific PTEN inhibitor with IC50 of 2 μM.
Adiponectin (APN) combined with SF1670 promotes osteogenesis of human bone marrow stromal cells (hBMSCs). Cells were cultured in proliferation medium (PM) and osteoinduction conditioned medium (OM). The expression of osteogenic differentiation-related genes in hBMSCs cultured in OM with 1.0 μg/mL APN combined with 5 μM SF1670 at day 7 (a, b) and day 14 (c, d).
VO-Ohpic is a potent inhibitor of PTEN (phosphatase and tensin homolog) with IC50 of 35 nM.