Alamandine

製品コード：P1107 純度：99.85%

Alamandine is a component of the renin-angiotensin system, which regulates blood pressure.

Amino-acid Sequence

CAS No. 1176306-10-7

サイズ	価格(税別)	在庫状況
5mg	JPY 17400	国内在庫あり
25mg	JPY 49000	国内在庫あり
バルクサイズ	バルク特価あり

代表番号: 045-509-1970\|電子メール：[email protected] よく尋ねられる質問

現在のバッチを見る：純度： 99.85%

99.85

保管	3 years-20°C powder	溶液の保管冷凍と解凍の繰り返しを避けるため小分けにしてください	1年-80°Cin solvent
			1个月-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (116.95 mM)；吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。)

Water : 100 mg/mL

Ethanol : Insoluble

in vivo
Batch:

Add solvents to the product individually and in order.

製品説明	Alamandine is a component of the renin-angiotensin system, which regulates blood pressure.

In vitro
In vitro	Alamandine decreases leptin secretion and expression in isolated adipocytes mediated by Gq, c-Src, p38 mitogen-activated protein and IκB activation, also induces nitric oxide expression via inducible nitric oxidase synthase and plasminogen activator inhibitor 1 expression in isolated adipocytes.^[2]
細胞実験	細胞株	adipocytes isolated from rats, 3T3L-1 adipocytes
	濃度	0.01, 0.1, 1, 10, 100, 1000 nM
	反応時間	24 h
	実験の流れ	Isolated adipocytes are incubated with alamandine for 24 h. Secreted leptin levels are determined using a leptin immunoassay kit according to the manufacturer’s protocol.

In Vivo
In vivo	Moderately concentrated alamandine reduces blood leptin levels in vivo.^[2]
動物実験	動物モデル	Wistar rats (10-week-old)
	投与量	576, 57.6, 5.76, or 0.576 µg/kg
	投与経路	i.p.

参考
[1] Soltani Hekmat A,et al. Circ J. 2017 Feb 24;81(3):405-412. [2] Uchiyama T, et al. PLoS One. 2017 Jun 7;12(6):e0178769.

参考

Molecular Formula	C₄₀H₆₂N₁₂O₉
Molecular Weight	855
CAS No.	1176306-10-7
Appearance	White Powder
Peptide Content (by %N)	≥80%
Single Impurity (by HPLC)	≤1.0%
Assay (By Anhydrous, Acetic Acid-free)	95.0~105.0%
MS	Consistent
Packing	plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage (From the date of receipt)	3 years-20°C powder
Shipping	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)