Desmopressin Acetate

製品コード：P1084 純度：99.02%

Desmopressin is a synthetic octapeptide, and an analogue of human hormone arginine vasopressin with antidiuretic and coagulant activities. It is a selective agonist for the vasopressin V2 receptor (V2R).

Amino-acid Sequence

CAS No. 62288-83-9

サイズ	価格(税別)	在庫状況
5mg	JPY 20200	国内在庫あり
25mg	JPY 58100	国内在庫あり
100mg	JPY 130100	国内在庫なし(納期7~10日)
バルクサイズ	バルク特価あり

代表番号: 045-509-1970\|電子メール：[email protected] よく尋ねられる質問

製品安全説明書

現在のバッチを見る：純度： 99.02%

99.02

化学情報

保管	3 years-20°C powder	溶液の保管冷凍と解凍の繰り返しを避けるため小分けにしてください	1年-80°Cin solvent
			1个月-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (88.55 mM)；吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。)

Water : 100 mg/mL

Ethanol : 100 mg/mL

モル濃度計算器

in vivo
Batch:

Add solvents to the product individually and in order.

投与溶液組成計算機

生物活性

製品説明	Desmopressin is a synthetic octapeptide, and an analogue of human hormone arginine vasopressin with antidiuretic and coagulant activities. It is a selective agonist for the vasopressin V2 receptor (V2R).

In vitro
In vitro	Desmopressin (DDAVP) is a selective agonist for the vasopressin V2 receptor (V2R), which is coupled to cAMP-dependent signaling. DDAVP induces cAMP-dependent eNOS activation via Ser1177 phosphorylation^[1]. DDAVP (at doses ranging from 100 ng/ml to 1 μg/ml) exerts a modest but significant antiproliferative effect on cultured CT-26 and Colo-205 cells^[2].
細胞実験	細胞株	HUVECs
	濃度	1 μM
	反応時間	25 min
	実験の流れ	HUVECs are transduced with recombinant adenoviruses AdV2R.EGFP (AdV2R) or AdlacZ. 3 days later cells are incubated for 25 min with 1 μM DDAVP or 10 μM forskolin, both in presence of IBMX. Cell extracts are analyzed for eNOS Ser1177 phosphorylation and eNOS expression.

In Vivo
In vivo	In vivo, DDAVP (2 μg/kg) reduces accumulation of ascites and formation of intestinal tumor nodules in mice intraperitoneally inoculated with CT-26 cells. Perioperative administration of DDAVP significantly inhibits tumor progression in animals surgically implanted in the spleen with CT-26 cells, and causes some reduction in liver metastasis. DDAVP is able to inhibit lung colonization by blood-borne breast cancer cells in an experimental murine model. It dramatically reduces lymph node and lung metastasis in a model of mammary tumor manipulation and surgical excision in mice when administered perioperatively, and also exerts antitumor effects in combination with chemotherapy^[2]. DDAVP increases the plasma levels of coagulation factor VIII, von Willebrand factor (VWF) and tissue-type plasminogen activator, and also enhances platelet adhesion to the vessel wall^[1].
動物実験	動物モデル	Syngeneic adult male Balb/c mice inoculated intraperitoneally or intrasplenically with CT-26 colon cancer cells
	投与量	2 μg/kg body weight
	投与経路	i.v.

参考
[1] Kaufmann JE, et al. J Thromb Haemost. 2003, 1(4):821-8. [2] Kaufmann JE, et al. J Thromb Haemost. 2003, 1(4):821-8.

参考

製品情報

Molecular Formula	C₄₆H₆₄N₁₄O₁₂S₂.C₂H₄O₂
Molecular Weight	1129.27
CAS No.	62288-83-9
Appearance	White Powder
Peptide Content (by %N)	≥80%
Single Impurity (by HPLC)	≤1.0%
Assay (By Anhydrous, Acetic Acid-free)	95.0~105.0%
MS	Consistent
Packing	plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage (From the date of receipt)	3 years-20°C powder
Shipping	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)