PMX 205 acetate

製品コード：P1208 純度：99.47%

PMX 205 acetate is a cyclic hexapeptide that acts as a potent C5a receptor (C5aR, CD88) antagonist with an IC50 of 31 nM.

Amino-acid Sequence

CAS No. 514814-49-4（free base)

サイズ	価格(税別)	在庫状況
5mg	JPY 45000	国内在庫あり
25mg	JPY 131100	国内在庫あり
バルクサイズ	バルク特価あり

代表番号: 045-509-1970\|電子メール：[email protected] よく尋ねられる質問

現在のバッチを見る：純度： 99.47%

99.47

保管	3 years-20°C powder	溶液の保管冷凍と解凍の繰り返しを避けるため小分けにしてください	1年-80°Cin solvent
			1个月-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (119.18 mM)；吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。)

Ethanol : 100 mg/mL

Water : 50 mg/mL

in vivo
Batch:

Add solvents to the product individually and in order.

製品説明

PMX 205 acetate is a cyclic hexapeptide that acts as a potent C5a receptor (C5aR, CD88) antagonist with an IC50 of 31 nM.

Targets

C5a receptor

31 nM

In Vivo
In vivo	In Tg2576 mice, PMX205 treatment decreases both total amyloid deposits and fibrillar amyloid plaques and results in less reactive glia surrounding fibrillar amyloid plaques. PMX205 treatment causes significant decreases in hyperphosphorylated tau as well as fibrillar plaques in the 3xTg mouse model.^[2]

参考
[1] Vinod Kumar, et al. ACS Omega . 2020 Jan 30;5(5):2345-2354. [2] Maria I Fonseca, et al. J Immunol. 2009 Jul 15;183(2):1375-83.

参考

Molecular Formula	C₄₅H₆₂N₁₀O₆
Molecular Weight	839.04
CAS No.	514814-49-4（free base)
Appearance	White Powder
Peptide Content (by %N)	≥80%
Single Impurity (by HPLC)	≤1.0%
Assay (By Anhydrous, Acetic Acid-free)	95.0~105.0%
MS	Consistent
Packing	plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage (From the date of receipt)	3 years-20°C powder
Shipping	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)