TLQP-21 TFA

製品コード：P1209 純度：99.90%

LQP-21 TFA (TLQP-21 Trifluoroacetate) is a VGF-derived peptide that activates the C3aR1 receptor through a folding-upon-binding mechanism.

Amino-acid Sequence

CAS No. 869988-94-3(free base)

サイズ	価格(税別)	在庫状況
5mg	JPY 27400	国内在庫あり
25mg	JPY 79300	国内在庫あり
バルクサイズ	バルク特価あり

代表番号: 045-509-1970\|電子メール：[email protected] よく尋ねられる質問

現在のバッチを見る：純度： 99.90%

99.90

保管	3 years-20°C powder	溶液の保管冷凍と解凍の繰り返しを避けるため小分けにしてください	1年-80°Cin solvent
			1个月-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (39.26 mM)；吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。)

Water : 100 mg/mL

Ethanol : 100 mg/mL

in vivo
Batch:

Add solvents to the product individually and in order.

製品説明

LQP-21 TFA (TLQP-21 Trifluoroacetate) is a VGF-derived peptide that activates the C3aR1 receptor through a folding-upon-binding mechanism.

Targets

C3aR1 receptor

In vitro
In vitro	TLQP-21 activates the cognate C3aR1 receptor leading to enhanced lipolysis in adipocytes and arginine 21 is essential for TLQP-21 lipolysis in 3T3L1 adipocytes.^[1]
細胞実験	細胞株	3T3L1 adipocytes
	濃度	100 nM
	反応時間	3 h
	実験の流れ	3T3-L1 adipocytes differentiated on 6-well plates are first starved for 3 hours in KRH with 1% BSA, then incubate with TLQP-21 in the presence and absence of specific agonists/antagonists, suspended in KRH with 4% BSA. Following 3 hours of incubation at 37°C and 5% CO2, the media is collected and incubated at 60°C for 20 min to inactivate any residual enzymatic reaction activity. The cells are gathered for protein concentration or trypsinized for cell diameter and viability measurements.

参考
[1] Cheryl Cero, et al. Structure . 2014 Dec 2;22(12):1744-1753.

参考

Molecular Formula	C₁₀₇H₁₇₀N₄₀O₂₆(TFA)
Molecular Weight	2546.75
CAS No.	869988-94-3(free base)
Appearance	White Powder
Peptide Content (by %N)	≥80%
Single Impurity (by HPLC)	≤1.0%
Assay (By Anhydrous, Acetic Acid-free)	95.0~105.0%
MS	Consistent
Packing	plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage (From the date of receipt)	3 years-20°C powder
Shipping	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)