Atezolizumab (anti-PD-L1)

製品コードA2004 別名: MPDL3280A

Atezolizumab is a fully humanized, IgG1 monoclonal antibody that blocks the interaction of PD-L1 with both PD-1 and B7.1, but not the interaction of PD-L2 with PD-1. MW : 145 KD.

Atezolizumab (anti-PD-L1)
サイズ 価格(税別) 在庫状況
1mg JPY 44500 国内在庫あり
5mg JPY 146500 国内在庫あり
1mg*5 JPY 146500 お問い合わせ
1mg*25 JPY 445500 お問い合わせ

代表番号: 045-509-1970|電子メール:[email protected]
よく尋ねられる質問

文献中Selleckの製品使用例(47)

質量管理及び製品安全説明書

現在のバッチを見る: 純度: 99% タンパク質濃度: 13.03mg/ml 内毒素: <1EU/mg
99

PD-1/PD-L1阻害剤の選択性比較

生物活性

製品説明 Atezolizumab is a fully humanized, IgG1 monoclonal antibody that blocks the interaction of PD-L1 with both PD-1 and B7.1, but not the interaction of PD-L2 with PD-1. MW : 145 KD.
同型 Human IgG1
Targets
hPD-L1 [2]
(Cell-free assay)
0.4 nM(Kd)
In Vitro
In Vitro

Treatment with single agent atezolizumab exerted a moderate anti-proliferative effect with ~ 30% cell death across all models.[1]

細胞実験

A MTT cell proliferation assays in human spheroids (A) or EPCAM+/CD45- cells (b), untreated or treated with selumetinib, atezolizumab, avelumab, or their combinations.

In Vivo
In Vivo

when dual drug–loaded, core-shell nanoparticles (DLTPT) is used in combination with anti PD-L1, the tumor growth is inhibited, which induced immune response against tumor metastasis.[2]

動物試験

Animal Models: 4T1 tumor–bearing BALB/c mice
Dosages: 2.5 or 5 mg/kg
Administration: i.v.
Reference:[2]

製品説明

CAS No. 1380723-44-3
Formulation PBS buffer, pH 7.2
Isotype Human IgG1
Source CHO cells
Storage
(From the date of receipt)
Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles
Shipping Shipped under low temperature conditions
Sterility 2.9mg/ml

技術サポート

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Handling Instructions

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よくある質問(FAQ)

質問:1:
How to store the antibody?

回答:
Store the undiluted solution at 4 °C in the dark. Freezing antibodies can result in a loss of activity caused by the freezing/thawing process. Diluting antibodies to working concentrations and storing at 4°C for more than a day should be avoided. Additionally, make sure to keep the antibody sterile. Under these storage conditions, your antibodies should remain active for up to one year and oftentimes longer.

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