Pembrolizumab (anti-PD-1)

製品コードA2005 別名: MK-3475, lambrolizumab

Pembrolizumab is a potent, highly selective, fully humanized immunoglobulin (Ig) G4-kappa monoclonal antibody against PD-1 with potential immune checkpoint inhibitory and antineoplastic activities. MW : 146.286 KD.

Pembrolizumab (anti-PD-1)
サイズ 価格(税別) 在庫状況
1mg JPY 44500 国内在庫あり
1mg*5 JPY 146500 お問い合わせ
5mg JPY 146500 国内在庫あり
1mg*25 JPY 445500 お問い合わせ

代表番号: 045-509-1970|電子メール:[email protected]
よく尋ねられる質問

文献中Selleckの製品使用例(46)

質量管理及び製品安全説明書

現在のバッチを見る: 純度: 99% タンパク質濃度: 15.94mg/ml 内毒素: <1EU/mg
99

PD-1/PD-L1阻害剤の選択性比較

生物活性

製品説明 Pembrolizumab is a potent, highly selective, fully humanized immunoglobulin (Ig) G4-kappa monoclonal antibody against PD-1 with potential immune checkpoint inhibitory and antineoplastic activities. MW : 146.286 KD.
同型 Human IgG4
Targets
PD-1 [1]
(Cell-free assay)
In Vitro
In Vitro

The level of LDH and apoptosis are significantly higher in those treated with dexamethasone plus PD1 inhibitor pembrolizumab than other groups.[1]

細胞実験

Cancer cells were incubated with dexamethasone for 48 h followed by co-cultured with PBMCs with effector/target ratio of 10:1 and the addition of PD1 inhibitor (pembrolizumab; 5 μg/mL) for another 48 h. LDH level was detected.

In Vivo
In Vivo

Pembrolizumab and dexamethasone synergistically suppress tumor growth of pancreatic cancer in vivo.[1]

動物試験

Animal Models: Immune reconstituted NOD/SCID mice model
Dosages: 5 mg/kg
Administration: i.v.
Reference: [1]
 

製品説明

CAS No. 1374853-91-4
Formulation PBS buffer, pH 7.2
Isotype Human IgG4
Source CHO cells
Storage
(From the date of receipt)
Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles
Shipping Shipped under low temperature conditions
Sterility 5.09mg/ml

技術サポート

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Handling Instructions

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よくある質問(FAQ)

質問:1:
How to store the antibody?

回答:
Store the undiluted solution at 4 °C in the dark. Freezing antibodies can result in a loss of activity caused by the freezing/thawing process. Diluting antibodies to working concentrations and storing at 4°C for more than a day should be avoided. Additionally, make sure to keep the antibody sterile. Under these storage conditions, your antibodies should remain active for up to one year and oftentimes longer.

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