RNR

RNR製品

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  • RNR阻害剤 (5)
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S1218 Clofarabine Clofarabine (Clolar) inhibits the enzymatic activities of ribonucleotide reductase (RNR) (IC50 = 65 nM) and DNA polymerase. Clofarabine induces autophagy and apoptosis.
Front Oncol, 2023, 13:1287444
Cancer Res, 2022, 82(4):721-733
Clin Transl Med, 2022, 12(2):e747
S7470 Triapine (3-AP) Triapine (3-AP) is a potent ribonucleotide reductase (RNR) inhibitor with broad spectrum antitumor activity by inhibiting DNA synthesis. Phase 2.
J Virol, 2023, 97(8):e0026723
Res Sq, 2023, rs.3.rs-3126261
Cancer Res, 2022, 82(4):721-733
S0283 COH-29 COH29 (RNR Inhibitor COH29) is a potent inhibitor of ribonucleotide reductase (RNR) with anticancer activity. COH29 (RNR Inhibitor COH29) inhibits recombinant RNR small subunit (RRM1/RRM2) activity in vitro with IC50 of 16 μM.
Adv Sci (Weinh), 2021, e2100881
S3385 NSAH NSAH (HNASH) is a reversible and competitive nonnucleoside ribonucleotide reductase (RNR) inhibitor, with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively.
Pharmaceutics, 2022, 14-71387
S3641 Osalmid Osalmid suppresses ribonucleotide reductase (RR) activity in a concentration-dependent manner, with a 50% RR activity-inhibitory concentration (IC50) of 8.23 μM.
S1218 Clofarabine Clofarabine (Clolar) inhibits the enzymatic activities of ribonucleotide reductase (RNR) (IC50 = 65 nM) and DNA polymerase. Clofarabine induces autophagy and apoptosis.
Front Oncol, 2023, 13:1287444
Cancer Res, 2022, 82(4):721-733
Clin Transl Med, 2022, 12(2):e747
S7470 Triapine (3-AP) Triapine (3-AP) is a potent ribonucleotide reductase (RNR) inhibitor with broad spectrum antitumor activity by inhibiting DNA synthesis. Phase 2.
J Virol, 2023, 97(8):e0026723
Res Sq, 2023, rs.3.rs-3126261
Cancer Res, 2022, 82(4):721-733
S0283 COH-29 COH29 (RNR Inhibitor COH29) is a potent inhibitor of ribonucleotide reductase (RNR) with anticancer activity. COH29 (RNR Inhibitor COH29) inhibits recombinant RNR small subunit (RRM1/RRM2) activity in vitro with IC50 of 16 μM.
Adv Sci (Weinh), 2021, e2100881
S3385 NSAH NSAH (HNASH) is a reversible and competitive nonnucleoside ribonucleotide reductase (RNR) inhibitor, with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively.
Pharmaceutics, 2022, 14-71387
S3641 Osalmid Osalmid suppresses ribonucleotide reductase (RR) activity in a concentration-dependent manner, with a 50% RR activity-inhibitory concentration (IC50) of 8.23 μM.

RNR阻害剤の選択性比較

Tags: RNR inhibitor|RNR agonist|RNR activator|RNR inducer|RNR antagonist|RNR signaling pathway|RNR assay kit