DHFR

信号経路図

研究分野

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1135 Pemetrexed 94 mg/mL <1 mg/mL <1 mg/mL
S1210 Methotrexate <1 mg/mL 90 mg/mL <1 mg/mL
S1497 Pralatrexate <1 mg/mL 28 mg/mL <1 mg/mL
S2006 Pyrimethamine <1 mg/mL 10 mg/mL <1 mg/mL
S1618 Sulfameter <1 mg/mL 56 mg/mL <1 mg/mL
S7785 Pemetrexed Disodium Hydrate 100 mg/mL <1 mg/mL <1 mg/mL
製品コード 製品説明 文献中の使用例 お客様のフィードバック
S1135

Pemetrexed

Pemetrexedは一種の新たな葉酸代謝拮抗剤と抗代謝薬物ですが、無細胞試験でTS、DHFRとGARFTに作用する時のKi値が1.3nM、7.2nMと65nMにそれぞれ分かれます。

S1210

Methotrexate

Methotrexate is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities.

S1497

Pralatrexate

Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines.

S2006

Pyrimethamine

Pyrimethamine is a dihydrofolate reductase(DHFR) inhibitor with an IC50 of 15.4 nM.

S1618

Sulfameter

Sulfameter(Bayrena) is a long-acting sulfonamide antibacterial.

S7785

Pemetrexed Disodium Hydrate

Pemetrexed Disodium Hydrate is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.

製品コード 製品説明 文献中の使用例 お客様のフィードバック
S1135

Pemetrexed

Pemetrexedは一種の新たな葉酸代謝拮抗剤と抗代謝薬物ですが、無細胞試験でTS、DHFRとGARFTに作用する時のKi値が1.3nM、7.2nMと65nMにそれぞれ分かれます。

S1210

Methotrexate

Methotrexate is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities.

S1497

Pralatrexate

Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines.

S2006

Pyrimethamine

Pyrimethamine is a dihydrofolate reductase(DHFR) inhibitor with an IC50 of 15.4 nM.

S1618

Sulfameter

Sulfameter(Bayrena) is a long-acting sulfonamide antibacterial.

S7785

Pemetrexed Disodium Hydrate

Pemetrexed Disodium Hydrate is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.