Factor Xa

シグナル伝達経路

研究分野

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S3002 Rivaroxaban <1 mg/mL 87 mg/mL <1 mg/mL
S1593 Apixaban <1 mg/mL 18 mg/mL <1 mg/mL
S7280 Edoxaban <1 mg/mL 100 mg/mL <1 mg/mL
製品コード 製品説明 文献中の使用例 お客様のフィードバック
S3002

Rivaroxaban

Rivaroxaban is a direct inhibitor of Factor Xa with Ki and IC50 of 0.4 nM and 0.7 nM in cell-free assays, respectively. It is selective for human factor Xa, for which it has >10 000-fold greater selectivity than for other biologically relevant serine proteases (IC50 >20 μM).

S1593

Apixaban

Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively.

S7280

Edoxaban

Edoxaban is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug.