RAAS

信号経路図

研究分野

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S2199 Aliskiren Hemifumarate 100 mg/mL 100 mg/mL 100 mg/mL
S1578 Candesartan <1 mg/mL 88 mg/mL 1 mg/mL
S1359 Losartan Potassium (DuP 753) 92 mg/mL 92 mg/mL 92 mg/mL
S1657 Enalaprilat Dihydrate <1 mg/mL 70 mg/mL <1 mg/mL
S1738 Telmisartan <1 mg/mL 13 mg/mL <1 mg/mL
S1507 Irbesartan <1 mg/mL 4 mg/mL 3 mg/mL
S1894 Valsartan <1 mg/mL 87 mg/mL 87 mg/mL
S7098 PD123319 100 mg/mL 100 mg/mL 100 mg/mL
S1506 Perindopril Erbumine 88 mg/mL <1 mg/mL 88 mg/mL
S1284 Benazepril HCl 19 mg/mL 92 mg/mL 92 mg/mL
S1604 Olmesartan Medoxomil <1 mg/mL 89 mg/mL <1 mg/mL
S2037 Candesartan Cilexetil <1 mg/mL 122 mg/mL 4 mg/mL
S1793 Ramipril <1 mg/mL 83 mg/mL 83 mg/mL
S1941 Enalapril Maleate <1 mg/mL 99 mg/mL 4 mg/mL
S2051 Captopril 2 mg/mL 43 mg/mL 43 mg/mL
S2076 Lisinopril 20 mg/mL <1 mg/mL <1 mg/mL
S2081 Cilazapril Monohydrate <1 mg/mL 87 mg/mL 87 mg/mL
S3057 Azilsartan Medoxomil <1 mg/mL 114 mg/mL <1 mg/mL
S2079 Moexipril HCl <1 mg/mL 20 mg/mL <1 mg/mL
S2581 Quinapril HCl 95 mg/mL 18 mg/mL 95 mg/mL
S2099 Temocapril HCl <1 mg/mL 103 mg/mL 103 mg/mL
S2109 Imidapril HCl 54 mg/mL 88 mg/mL 29 mg/mL
S3046 Azilsartan <1 mg/mL 91 mg/mL <1 mg/mL
S7678 LCZ696 100 mg/mL 30 mg/mL 9 mg/mL
S4102 Eprosartan Mesylate <1 mg/mL 104 mg/mL 4 mg/mL
S2095 Fosinopril Sodium 117 mg/mL <1 mg/mL 4 mg/mL

亜型選択性的な製品

製品コード 製品説明 文献中の使用例 お客様のフィードバック
S2199

Aliskiren Hemifumarate

アリスキレン・ヘミフマル酸エステルは、直接的なレニン</b> 阻害剤で、IC50が 1.5 nMです。

S1578

Candesartan

Candesartan is an angiotensin II receptor antagonist with an IC50 of 15 μg/kg.

S1359

Losartan Potassium (DuP 753)

Losartan Potassium (DuP 753) is an angiotensin II receptor antagonist drug.

S1657

Enalaprilat Dihydrate

Enalaprilat Dihydrateは新型血管緊張ペプチド転換酵素阻害剤(ACE)、IC50が1.2nMになる。

S1738

Telmisartan

Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.

S1507

Irbesartan

Irbesartanは、非常に強力で特定のアンギオテンシンIIタイプ1(AT1)受容体拮抗剤で、IC50 が 1.3 nMになる。

S1894

Valsartan

Valsartan is an angiotensin II receptor antagonist with IC50 of ranging from 39.5 to 116 μM.

S7098

PD123319

PD 123319 is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.

S1506

Perindopril Erbumine

Perindopril Erbumineは独特な triazolone-containing Hsp90阻害剤、 IC50 が4 nM となる.

S1284

Benazepril HCl

Benazepril HCl is a medication used to treat high blood pressure.

S1604

Olmesartan Medoxomil

Olmesartan medoxomil is a compound which is hydrolyzed to olmesartan that is a selective AT1 subtype angiotensin II receptor antagonist.

S2037

Candesartan Cilexetil

Candesartan Cilexetil is an angiotensin II receptor antagonist with IC50 of 0.26 nM, used in the treatment of hypertension.

S1793

Ramipril

Ramipril は アンジオテンシン変換酵素(ACE)阻害剤、 IC50 が 5 nMになる.

S1941

Enalapril Maleate

Enalapril Maleate, the active metabolite of enalapril, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II.

S2051

Captopril

Captopril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.

S2076

Lisinopril

Lisinopril is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.

S2081

Cilazapril Monohydrate

Cilazapril Monohydrate is a angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.

S3057

Azilsartan Medoxomil

Azilsartan Medoxomil is a potent angiotensin II type 1 (AT1) receptor antagonist, inhibits the RAAS, with an IC50 of 2.6 nM, exhibits >10,000-fold selectivity over AT2.

S2079

Moexipril HCl

Moexipril HCl is a potent orally active non-sulfhydryl angiotensin converting enzyme inhibitor (ACE) with IC50 of 0.041 μM, which is used for the treatment of hypertension and congestive heart failure.

S2581

Quinapril HCl

Quinapril HCl is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM.

S2099

Temocapril HCl

Temocapril HCl is the hydrochloride of Temocapril, which is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.

S2100

Temocapril

Temocapril is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.

S2109

Imidapril HCl

Imidapril HCl is a angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension.

S3046

Azilsartan

Azilsartan is an angiotensin II type 1 (AT1) receptor antagonist with IC50 of 2.6 nM.

S7678

LCZ696

LCZ696, consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.

S4102

Eprosartan Mesylate

Eprosartan is a nonpeptide angiotensin II receptor antagonist, [3H]-eprosartan binds to the AT1 receptor with KD of 0.83 nM in rat vascular smooth muscle cells.

S2095

Fosinopril Sodium

Fosinopril sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.