ヒスタミン受容体

信号経路図

研究分野

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1847 Clemastine Fumarate <1 mg/mL 35 mg/mL <1 mg/mL
S1245 Latrepirdine 2HCl <1 mg/mL 24 mg/mL 13 mg/mL
S1358 Loratadine <1 mg/mL 17 mg/mL 76 mg/mL
S3037 Bepotastine Besilate <1 mg/mL 109 mg/mL <1 mg/mL
S1382 Mianserin HCl 30 mg/mL 60 mg/mL 21 mg/mL
S8598 S 38093 <1 mg/mL 57 mg/mL 57 mg/mL
S2552 Azelastine HCl 35 mg/mL 28 mg/mL 42 mg/mL
S1801 Ranitidine Hydrochloride 70 mg/mL 70 mg/mL <1 mg/mL
S1866 Diphenhydramine HCl 58 mg/mL 58 mg/mL 58 mg/mL
S1291 Cetirizine DiHCl 92 mg/mL 92 mg/mL <1 mg/mL
S4012 Desloratadine <1 mg/mL 26 mg/mL 62 mg/mL
S1816 Chlorpheniramine Maleate 78 mg/mL 78 mg/mL 78 mg/mL
S2813 Ciproxifan Maleate 1 mg/mL 54 mg/mL 54 mg/mL
S1986 Meclizine 2HCl <1 mg/mL 4 mg/mL <1 mg/mL
S2107 Mizolastine <1 mg/mL <1 mg/mL <1 mg/mL
S1845 Cimetidine <1 mg/mL 51 mg/mL 3 mg/mL
S3208 Fexofenadine HCl 2 mg/mL 107 mg/mL 107 mg/mL
S2065 Lafutidine <1 mg/mL 86 mg/mL 13 mg/mL
S4253 Epinastine HCl 57 mg/mL 57 mg/mL 57 mg/mL
S1890 Nizatidine 28 mg/mL 66 mg/mL 18 mg/mL
S3146 Tripelennamine HCl 58 mg/mL 2 mg/mL 1 mg/mL
S2494 Olopatadine HCl 13 mg/mL 75 mg/mL 8 mg/mL
S2044 Cyproheptadine HCl <1 mg/mL 65 mg/mL 20 mg/mL
S4026 Hydroxyzine 2HCl 90 mg/mL 90 mg/mL 15 mg/mL
S1357 Lidocaine 9 mg/mL 47 mg/mL 47 mg/mL
S4140 Buclizine HCl <1 mg/mL 0.2 mg/mL <1 mg/mL
S4262 Ebastine <1 mg/mL 4 mg/mL 11 mg/mL
S2585 Brompheniramine hydrogen maleate 46 mg/mL 87 mg/mL 18 mg/mL
S3052 Rupatadine Fumarate <1 mg/mL 9 mg/mL 13 mg/mL
S2024 Ketotifen Fumarate <1 mg/mL 8 mg/mL <1 mg/mL
S2905 JNJ-7777120 <1 mg/mL 56 mg/mL 8 mg/mL
S3186 Azatadine dimaleate 105 mg/mL 105 mg/mL <1 mg/mL
S4008 Pemirolast potassium 53 mg/mL <1 mg/mL <1 mg/mL
S4117 Histamine Phosphate 42 mg/mL <1 mg/mL <1 mg/mL
S4118 Histamine 2HCl 37 mg/mL 3 mg/mL <1 mg/mL
S4131 Levodropropizine 15 mg/mL 47 mg/mL 47 mg/mL
S4139 Cyclizine 2HCl 68 mg/mL 7 mg/mL <1 mg/mL
S4625 Alcaftadine <1 mg/mL 28 mg/mL 61 mg/mL
S4045 Pheniramine Maleate 71 mg/mL 71 mg/mL 71 mg/mL
S1880 Roxatidine Acetate HCl 77 mg/mL 77 mg/mL 12 mg/mL
S2308 Hesperetin <1 mg/mL 60 mg/mL <1 mg/mL
S4696 ArbinoxaMine Maleate 81 mg/mL 81 mg/mL 81 mg/mL
S4240 Doxylamine Succinate 78 mg/mL 78 mg/mL 78 mg/mL
S2078 Famotidine <1 mg/mL 67 mg/mL <1 mg/mL
S3176 Betahistine 2HCl 38 mg/mL 38 mg/mL 1 mg/mL
S4293 Promethazine HCl 64 mg/mL 64 mg/mL 34 mg/mL

亜型選択性的な製品

製品コード 製品説明 文献中の使用例 お客様のフィードバック
S1847

Clemastine Fumarate

Clemastine Fumarateは選択的なヒスタミンH1受容体拮抗剤で、IC50 が 3 nMになる。

S1245

Latrepirdine 2HCl

Latrepirdineは一種の経口活性と神経活性の多種薬物ターゲット拮抗剤ですが、ヒスタミン受容体、GluRと5-HT受容体を含めて、抗ヒスタミン薬物として作用します。

S1358

Loratadine

Loratadine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.

S3037

Bepotastine Besilate

Bepotastine Besilate is a non-sedating, selective antagonist of histamine 1 (H1) receptor with pIC50 of 5.7.

S1382

Mianserin HCl

Mianserin is an potent antagonist of H1 histamine receptor and 5-HT serotonin receptors, used for the treatment of depression.

S8598

S 38093

S2552

Azelastine HCl

Azelastine HCl is a potent, second-generation, selective, histamine receptor antagonist, used in the treatment of rhinitis.

S1801

Ranitidine Hydrochloride

Ranitidine is a histamine H2-receptor antagonist with IC50 of 3.3 ± 1.4 μM.

S1866

Diphenhydramine HCl

Diphenhydramine HCl (Benadryl), a histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations.

S1291

Cetirizine DiHCl

Cetirizine DiHCl is an antihistamine.

S4012

Desloratadine

Desloratadine は、人間のヒスタミンH1のための強力な拮抗剤レセプターで、IC50 が 51 nMです。

S1816

Chlorpheniramine Maleate

Chlorpheniramine MaleateはヒスタミンH1受容体拮抗剤で、IC50 が 12 nMになる。

S2813

Ciproxifan Maleate

Ciproxifanは、非常に有力で選択的なH3-receptorレセプター 敵対者で、IC50 が 9.2 nMです。

S1986

Meclizine 2HCl

Meclizine is a histamine H1 receptor antagonist used to treat nausea and motion sickness, also an agonist ligand for mCAR (constitutive androstane receptor) and an inverse agonist for hCAR.

S2107

Mizolastine

Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.

S1845

Cimetidine

Cimetidine , a histamine congener, competitively inhibits histamine binding to histamine H2 receptors.

S3208

Fexofenadine HCl

Fexofenadine HCl inhibits histamine H1 receptor with IC50 of 246 nM.

S2065

Lafutidine

Lafutidine, a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion.

S4253

Epinastine HCl

Epinastine is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis.

S1890

Nizatidine

Nizatidine is a histamine H2-receptor antagonist with and IC50 of 6.7 nM for AChE.

S3146

Tripelennamine HCl

Tripelennamine HCl is a widely used H1 antagonist, inhibiting PhIP glucuronidation with IC50 of 30 μM.

S2494

Olopatadine HCl

Olopatadine HCl is a histamine blocker and mast cell stabilizer with an IC50 of 559 μM for the release of histamine

S2044

Cyproheptadine HCl

Cyproheptadine HCl is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist for 5-HT2 receptor with IC50 of 0.6 nM.

S4026

Hydroxyzine 2HCl

Hydroxyzine 2HClは[3H]の結合ピリラミンまたは[3H]デスロラタジン人間ヒスタミンH1への受容体を阻害、IC50 がそれぞれ10 nM と 19 nMです。

S1357

Lidocaine

Lidocaine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.

S4140

Buclizine HCl

Buclizine HClは、抗ヒスタミン剤、そして、抗コリン作用性ピペラジン誘導体族です。

S4262

Ebastine

Ebastinea is a potent H1-histamine receptor antagonist, used for allergic disorders.

S2585

Brompheniramine hydrogen maleate

Brompheniramine hydrogen maleate is a histamine H1 receptors antagonist.

S3052

Rupatadine Fumarate

Rupatadine Fumarate is an inhibitor of PAFR and histamine (H1) receptor with Ki of 550 nM and 102 nM, respectively. Phase 2.

S2024

Ketotifen Fumarate

Ketotifen Fumarate is a fumaric acid salt of ketotifen which is a H1-antihistamine and mast cell stabilizer.

S2905

JNJ-7777120

JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other histamin receptors.

S3186

Azatadine dimaleate

Azatadine dimaleate is an histamine and cholinergic inhibitor with IC50 of 6.5 nM and 10 nM, respectively.

S4008

Pemirolast potassium

Pemirolast potassium は、抗アレルギー性エージェントの働きをするヒスタミンH1敵対者と肥満細胞スタビライザーです。

S4117

Histamine Phosphate

Histamineは動脈を拡大するために直接血管に作用します、そして、毛細管はH 1-とH 2-レセプターによって仲介しました。

S4118

Histamine 2HCl

Histamine 2HClは、有機窒素合成物(Histamine 1/2の刺激を経た哺乳類の脳の標的細胞の幕)です。

S4131

Levodropropizine

Levodropropizineは、抗アレルギー性物質を所有します、そして、ヒスタミン受容体を妨げて、感覚神経の周辺的な結末の刺激起動で、そして、咳反射に関係するニューロペプチドの変調によって仲裁することによる咳を減らします。

S4139

Cyclizine 2HCl

Cyclizine 2HClは、Histamine H1によるピペラジン誘導体受容体拮抗剤活性です。

S4625

Alcaftadine

S4045

Pheniramine Maleate

Pheniramine Maleate is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria.

S1880

Roxatidine Acetate HCl

Roxatidine Acetate HCl is a specific and competitive histamin H2-receptor antagonist, with IC50 of 3.2 μM, inhibits gastric acid secretion and ulcer formation.

S2308

Hesperetin

Hesperetinは一種の生物類フラボンで、具体的に言えば、一種のフラバノン(flavanone)です。

S4696

ArbinoxaMine Maleate

Carbinoxamine maleateは1種のヒスタミン(histamine)H1受容体遮断剤で、抗ヒスタミンと抗コリン(anticholinergic )の作用をしています。

S4240

Doxylamine Succinate

Doxylamine succinateは、競争的にかなりの鎮静と抗コリン作用とH1受容体におけるヒスタミン阻害します。

S2078

Famotidine

Famotidine is a histamine H2–receptor antagonist with IC50 of 0.6 mM, commonly used to treat heartburn, GERD, ulcers, and other digestive conditions.

S3176

Betahistine 2HCl

Betahistine 2HCl is a histamine H3 receptors inhibitor with IC50 of 1.9 μM.

S4293

Promethazine HCl

Promethazine HCl is a potent histamine H1 receptor antagonist, used as a sedative and antiallergic medication.