ナトリウムチャネル

信号経路図

研究分野

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1614 Riluzole <1 mg/mL 46 mg/mL 46 mg/mL
S2454 Bupivacaine HCl 23 mg/mL 65 mg/mL 65 mg/mL
S1811 Amiloride HCl 6 mg/mL 53 mg/mL 5 mg/mL
S1256 Rufinamide <1 mg/mL 18 mg/mL <1 mg/mL
S1603 Furosemide <1 mg/mL 66 mg/mL <1 mg/mL
S1445 Zonisamide <1 mg/mL 42 mg/mL 5 mg/mL
S2524 Phenytoin Sodium 3 mg/mL 32 mg/mL 11 mg/mL
S1693 Carbamazepine <1 mg/mL 47 mg/mL 18 mg/mL
S2785 A-803467 <1 mg/mL 72 mg/mL 11 mg/mL
S2560 Amiloride HCl dihydrate 17 mg/mL 0 mg/mL 0 mg/mL
S2525 Phenytoin <1 mg/mL 50 mg/mL 13 mg/mL
S2874 Camostat Mesilate 10 mg/mL 99 mg/mL <1 mg/mL
S2114 Dronedarone HCl <1 mg/mL 80 mg/mL 40 mg/mL
S3024 Lamotrigine <1 mg/mL 10 mg/mL 3 mg/mL
S4016 Ouabain <1 mg/mL 100 mg/mL 100 mg/mL
S1965 Primidone <1 mg/mL 44 mg/mL 3 mg/mL
S3064 Ambroxol HCl <1 mg/mL 4 mg/mL <1 mg/mL
S2041 Dyclonine HCl 6 mg/mL 15 mg/mL 36 mg/mL
S4229 Oxybuprocaine HCl 69 mg/mL 69 mg/mL 69 mg/mL
S3155 Mepivacaine HCl 57 mg/mL 3 mg/mL 8 mg/mL
S2500 Propafenone HCl <1 mg/mL 69 mg/mL <1 mg/mL
S4023 Procaine HCl 55 mg/mL 55 mg/mL <1 mg/mL
S1619 Prilocaine <1 mg/mL 44 mg/mL 44 mg/mL
S4038 Dibucaine HCl 76 mg/mL 76 mg/mL 76 mg/mL
S1391 Oxcarbazepine <1 mg/mL 7 mg/mL <1 mg/mL
S4058 Ropivacaine HCl 46 mg/mL 62 mg/mL <1 mg/mL
S4180 Nefopam HCl 21 mg/mL 1 mg/mL <1 mg/mL
S4061 Levobupivacaine HCl 64 mg/mL 64 mg/mL 57 mg/mL
S4080 Triamterene <1 mg/mL 20 mg/mL <1 mg/mL
S4200 Tolperisone HCl 56 mg/mL 56 mg/mL 56 mg/mL
S4210 Benzocaine <1 mg/mL 33 mg/mL 33 mg/mL
S4669 Benzocaine hydrochloride <1 mg/mL 40 mg/mL 40 mg/mL
S4668 Procaine <1 mg/mL 47 mg/mL 47 mg/mL
S4225 Mexiletine HCl 43 mg/mL 43 mg/mL 43 mg/mL
S4235 Phenazopyridine HCl <1 mg/mL 50 mg/mL <1 mg/mL
S1828 Proparacaine HCl 66 mg/mL 12 mg/mL <1 mg/mL
S4284 Chloroprocaine HCl 61 mg/mL 61 mg/mL <1 mg/mL
S2110 Vinpocetine <1 mg/mL 3 mg/mL
S4290 Digoxin <1 mg/mL 100 mg/mL <1 mg/mL
S2118 Ibutilide Fumarate 89 mg/mL 89 mg/mL 89 mg/mL
S4294 54 mg/mL 54 mg/mL 54 mg/mL
製品コード 製品説明 文献中の使用例 お客様のフィードバック
S1614

Riluzole

Riluzole is a drug used to treat amyotrophic lateral sclerosis.

S2454

Bupivacaine HCl

Bupivacaine HCl is a more potent cAMP production inhibitor with an IC50 of 2.3 μM

S1811

Amiloride HCl

Amiloride hydrochloride(Midamor), a pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells.

S1256

Rufinamide

Rufinamide, a triazole derivative, is an anticonvulsant medication.

S1603

Furosemide

Furosemide(Lasix) is a loop diuretic used in the treatment of congestive heart failure and edema.

S1445

Zonisamide

Zonisamide is a sulfonamide anticonvulsant approved for use as an adjunctive.

S2524

Phenytoin Sodium

Phenytoin Sodium is an inactive voltage-gated sodium channel stabilizer.

S1693

Carbamazepine

Carbamazepineは一種のナトリウムチャネル阻害剤で、ラット大脳シナプトソーム(synaptosome)に作用する時のIC50値が131μMです。

S2785

A-803467

A-803467は、8nMのIC50をもつ選択的なNaV1.8チャンネル・ブロッカーです。

S2560

Amiloride HCl dihydrate

Amiloride HCl dihydrate is a potent epithelial sodium channel (ENaC) blocker, used in the management of hypertension and congestive heart failure.

S2525

Phenytoin

Phenytoin is an inactive voltage-gated sodium channel stabilizer.

S2874

Camostat Mesilate

Camostat is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase.

S2114

Dronedarone HCl

Dronedarone HCl is a therapy for the treatment of patients with paroxysmal and persistent atrial fibrillation or atrial flutter.

S3024

Lamotrigine

Lamotrigineは一種の新たな抗痙攣の薬物ですが、人間血小板とラット大脳シナプトソーム(synaptosome)の中に5-HTを抑制する時のIC50値が240μMと474μMに分かれます。同時に、Lamotrigineも一種のナトリウムチャネル遮断剤です。

S4016

Ouabain

Ouabainは、選択的なNa+、K+-ATPアーゼの阻害剤であり、α2サブユニットおよびα3サブユニットに結合し、Ki がそれぞれ41 nM と 15 nMです。

S1965

Primidone

Primidone(Mysoline) is an anticonvulsant of the pyrimidinedione class.

S3064

Ambroxol HCl

Ambroxol HCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.

S2041

Dyclonine HCl

Dyclonine hydrochloride is a hydrochloride salt form of dyclonine which is an oral anaesthetic.

S4229

Oxybuprocaine HCl

Oxybuprocaine HCl is a local anesthetic, which is used especially in ophthalmology and otolaryngology.

S3155

Mepivacaine HCl

Mepivacaine is a tertiary amine used as a local anesthetic.

S2500

Propafenone HCl

Propafenone HCl is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.

S4023

Procaine HCl

Procaine HCl is an inhibitor of sodium channel, NMDA receptor and nicotinic acetylcholine receptors with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM.

S1619

Prilocaine

Prilocaine is a local anesthetic of the amino amide type.

S4038

Dibucaine HCl

Dibucaine HClは局所麻酔薬です。

S1391

Oxcarbazepine

Oxcarbazepine is an anticonvulsant and mood stabilizing drug.

S4058

Ropivacaine HCl

Ropivacaine HCl を阻害 ナトリウムイオンの流入の可逆を通じて神経線維の麻酔薬とブロックインパルス伝導です。

S4180

Nefopam HCl

Nefopam HClは、セロトニン、ドーパミンおよびノルアドレナリン再取り込みの電位依存性ナトリウムチャネルと阻害をブロックすることにより、一元的作用が、非オピオイド鎮痛薬です。

S4061

Levobupivacaine HCl

Levobupivacaine HCl, the pure S(-)-enantiomer of bupivacaine, is a reversible neuronal sodium channel inhibitor, used as a long-acting local anesthetic.

S4080

Triamterene

Triamtereneブロック上皮Na+ チャネル(ENaC)の電圧依存的に、IC50 が 4.5 μMです

S4200

Tolperisone HCl

Tolperisone HCl is an ion channel blocker and centrally-acting muscle relaxant.

S4210

Benzocaine

Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA), it is a local anesthetic commonly used as a topical pain reliever or in cough drops.

S4669

Benzocaine hydrochloride

S4668

Procaine

S4225

Mexiletine HCl

Mexiletine HCl belongs to Class IB anti-arrhythmic group of medicines, inhibits sodium channels to reduce the inward sodium current.

S4235

Phenazopyridine HCl

Phenazopyridine HCl 尿路疾患で使用されている局所鎮痛薬。

S1828

Proparacaine HCl

Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.

S4284

Chloroprocaine HCl

Chloroprocaine HCl is a local anesthetic during surgical procedures.

S2110

Vinpocetine

Vinpocetine is a selectively inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia and Alzheimer's disease.

S4290

Digoxin

Digoxin is a sodium-potassium pump inhibitor, used in the treatment of atrial fibrillation and heart failure.

S2118

Ibutilide Fumarate

Ibutilide Fumarate is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and異໔畱✑畯腱瓳申⧸৆ﳈœ৆à

S4294

Procainamide HClは一種のナトリウムチャネル(sodium channel)遮断剤で、一種のDNAメチルトランスフェラーゼ阻害剤です。Procainamide HClは心不整脈の治療に使用します。