SGLT
信号経路図
研究分野
- 阻害剤の選択性比較
- 溶解度
| カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | アルコール | ||
| S1548 | Dapagliflozin | <1 mg/mL | 82 mg/mL | 17 mg/mL |
| S2760 | Canagliflozin | <1 mg/mL | 88 mg/mL | <1 mg/mL |
| S8022 | Empagliflozin (BI 10773) | <1 mg/mL | 90 mg/mL | <1 mg/mL |
| S8103 | Sotagliflozin (LX4211) | <1 mg/mL | 84 mg/mL | 17 mg/mL |
| S8558 | Tofogliflozin(CSG 452) | 4 mg/mL | 84 mg/mL | 84 mg/mL |
| S2342 | Phloretin | <1 mg/mL | 54 mg/mL | 54 mg/mL |
| S2343 | Phlorizin | <1 mg/mL | 87 mg/mL | 9 mg/mL |
亜型選択性的な製品
- SGLT阻害剤(7)
- 新SGLT製品
| 製品コード | 製品説明 | 文献中の使用例 | お客様のフィードバック |
|---|---|---|---|
| S1548 |
DapagliflozinDapagliflozinは、1.1nMのEC50による強力で選択的なhSGLT2阻害剤です。 |
(B) Clonogenic survival of prostate cancer cells treated with Canagliflozin, Dapagliflozin or Salicylate and expressed relative to the vehicle controls.
|
|
| S2760 |
CanagliflozinCanagliflozin は非常に強いと選択型2ナトリウム糖輸送蛋白（SGLT2）阻害剤 、 CHO- hSGLT2, CHO- rSGLT2 and CHO- mSGLT2 に作用する時、IC50 がそれぞれ 4.4 nM, 3.7 nM と 2 nMになる。 |
Canagliflozin dose-dependently increases pAMPK and pACC in PC3 cells after 30 min
|
|
| S8022 |
Empagliflozin (BI 10773)Empagliflozin（BI-10773）は、有力で選択的なSGLT2 阻害剤で、IC50 が3.1 nMです。 |
||
| S8103 |
Sotagliflozin (LX4211)Sotagliflozin (LX4211) is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively. Phase 3. |
||
| S8558新 |
Tofogliflozin(CSG 452) |
||
| S2342 |
PhloretinPhloretin is a dihydrochalcone, a type of polyphenol. |
||
| S2343 |
PhlorizinPhlorizin is a toxic 2’-glucoside of phloretin. It belongs to the group of dihydrochalcones, a type of flavonoids. |
The survival of cells treated with PQ in the presence or absence of STF-31 (d), phlorizin (e), or AA (f) was determined as explained
|
| 製品コード | 製品説明 | 文献中の使用例 | お客様のフィードバック |
|---|---|---|---|
| S1548 |
DapagliflozinDapagliflozinは、1.1nMのEC50による強力で選択的なhSGLT2阻害剤です。 |
(B) Clonogenic survival of prostate cancer cells treated with Canagliflozin, Dapagliflozin or Salicylate and expressed relative to the vehicle controls.
|
|
| S2760 |
CanagliflozinCanagliflozin は非常に強いと選択型2ナトリウム糖輸送蛋白（SGLT2）阻害剤 、 CHO- hSGLT2, CHO- rSGLT2 and CHO- mSGLT2 に作用する時、IC50 がそれぞれ 4.4 nM, 3.7 nM と 2 nMになる。 |
Canagliflozin dose-dependently increases pAMPK and pACC in PC3 cells after 30 min
|
|
| S8022 |
Empagliflozin (BI 10773)Empagliflozin（BI-10773）は、有力で選択的なSGLT2 阻害剤で、IC50 が3.1 nMです。 |
||
| S8103 |
Sotagliflozin (LX4211)Sotagliflozin (LX4211) is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively. Phase 3. |
||
| S8558新 |
Tofogliflozin(CSG 452) |
||
| S2342 |
PhloretinPhloretin is a dihydrochalcone, a type of polyphenol. |
||
| S2343 |
PhlorizinPhlorizin is a toxic 2’-glucoside of phloretin. It belongs to the group of dihydrochalcones, a type of flavonoids. |
The survival of cells treated with PQ in the presence or absence of STF-31 (d), phlorizin (e), or AA (f) was determined as explained
|
