SGLT
シグナル伝達経路
研究分野
- 阻害剤の選択性比較
- 溶解度
| カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | アルコール | ||
| S1548 | Dapagliflozin | <1 mg/mL | 82 mg/mL | 17 mg/mL |
| S2760 | Canagliflozin | <1 mg/mL | 88 mg/mL | <1 mg/mL |
| S8022 | Empagliflozin (BI 10773) | <1 mg/mL | 90 mg/mL | <1 mg/mL |
| S8103 | Sotagliflozin (LX4211) | <1 mg/mL | 84 mg/mL | 17 mg/mL |
| S8558 | Tofogliflozin(CSG 452) | 4 mg/mL | 84 mg/mL | 84 mg/mL |
| S8637 | Ipragliflozin (ASP1941) | <1 mg/mL | 80 mg/mL | 80 mg/mL |
| S2342 | Phloretin | <1 mg/mL | 54 mg/mL | 54 mg/mL |
| S2343 | Phlorizin | <1 mg/mL | 87 mg/mL | 9 mg/mL |
亜型選択性的な製品
- SGLT阻害剤(8)
- 新SGLT製品
| 製品コード | 製品説明 | 文献中の使用例 | お客様のフィードバック |
|---|---|---|---|
| S1548 |
DapagliflozinDapagliflozin is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM, exhibiting 1200-fold selectivity over hSGLT1. Phase 4. |
(B) Clonogenic survival of prostate cancer cells treated with Canagliflozin, Dapagliflozin or Salicylate and expressed relative to the vehicle controls.
|
|
| S2760 |
CanagliflozinCanagliflozin is a highly potent and selective SGLT2 inhibitor for hSGLT2 with IC50 of 2.2 nM in a cell-free assay, exhibits 413-fold selectivity over hSGLT1. |
Canagliflozin dose-dependently increases pAMPK and pACC in PC3 cells after 30 min
|
|
| S8022 |
Empagliflozin (BI 10773)Empagliflozin (BI-10773) is a potent and selective SGLT-2 inhibitor with IC50 of 3.1 nM, exhibits >300-fold selectivity over SGLT-1, 4, 5 and 6. Phase 3. |
||
| S8103 |
Sotagliflozin (LX4211)Sotagliflozin (LX4211) is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively. Phase 3. |
||
| S8558新 |
Tofogliflozin(CSG 452)Tofogliflozin is a novel sodium-glucose co-transporter 2(SGLT2) inhibitor with IC50 values of 2.9 nM and 8444 nM for hSGLT2 and Hsglt1, respectively. |
||
| S8637新 |
Ipragliflozin (ASP1941)Ipragliflozin (ASP1941) is a highly selective sodium-glucose cotransporter 2 (SGLT2) inhibitor with an IC50 value of 7.4 nM for hSGLT2 and a 254-fold selectivity versus SGLT1. |
||
| S2342 |
PhloretinPhloretin is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes. |
Specificity of FDG uptake in BJAB, OCI-LY3 and SU-DHL-6 cells. Cells were incubated without inhibitors or with 2 mM 2-DG, 5 μM cytochalasin B or 10 μM phloretin for 24 h or with 50 μM CoCl2 for 30 min and 100 kBq of FDG for 30 min. Cell-bound radioactivity was normalized to protein concentration determined from a parallel sample and expressed as % of untreated control, mean ± standard deviation from fourfold determinations; Asterisks indicates significant decrease or increase (p < 0.05, Student’s t test)
|
|
| S2343 |
PhlorizinPhlorizin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. |
The survival of cells treated with PQ in the presence or absence of STF-31 (d), phlorizin (e), or AA (f) was determined as explained
|
