カリウムチャネル

信号経路図

研究分野

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1658 Dofetilide <1 mg/mL 88 mg/mL <1 mg/mL
S2456 Chlorpromazine HCl 71 mg/mL 71 mg/mL 71 mg/mL
S1979 Amiodarone HCl <1 mg/mL 23 mg/mL 11 mg/mL
S1344 Glimepiride <1 mg/mL 11 mg/mL <1 mg/mL
S1160 TRAM-34 <1 mg/mL 0.4 mg/mL <1 mg/mL
S4733 Retigabine <1 mg/mL 60 mg/mL 35 mg/mL
S4734 Retigabine 2HCl 75 mg/mL 75 mg/mL 25 mg/mL
S1426 Repaglinide <1 mg/mL 91 mg/mL 91 mg/mL
S1971 Nicorandil 17 mg/mL 42 mg/mL 42 mg/mL
S2502 Quinine HCl Dihydrate 43 mg/mL 79 mg/mL 79 mg/mL
S1716 Glyburide (Glibenclamide) <1 mg/mL 99 mg/mL <1 mg/mL
S2443 Tolbutamide <1 mg/mL 54 mg/mL 54 mg/mL
S3151 Gliquidone <1 mg/mL 105 mg/mL 6 mg/mL
S2114 Dronedarone HCl <1 mg/mL 80 mg/mL 40 mg/mL
S2489 Nateglinide <1 mg/mL 63 mg/mL 63 mg/mL
S8016 Vonoprazan Fumarate (TAK-438) <1 mg/mL 62 mg/mL <1 mg/mL
S2825 ML133 HCl <1 mg/mL 63 mg/mL 6 mg/mL
S2562 Hydralazine HCl 1 mg/mL <1 mg/mL <1 mg/mL
S2601 Gliclazide <1 mg/mL 65 mg/mL <1 mg/mL
S4037 Doxapram HCl 25 mg/mL 87 mg/mL 2 mg/mL
S4630 Diazoxide <1 mg/mL 46 mg/mL <1 mg/mL
S4632 Hexachlorophene <1 mg/mL 81 mg/mL 81 mg/mL
S2073 Mitiglinide Calcium <1 mg/mL <1 mg/mL 2 mg/mL
製品コード 製品説明 文献中の使用例 お客様のフィードバック
S1658

Dofetilide

Dofetilide(Tikosyn) is a class III antiarrhythmic agent.

S2456

Chlorpromazine HCl

Chlorpromazine HCl is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for nward-rectifying K+ currents and time-independent outward currents

S1979

Amiodarone HCl

Amiodarone HClは一種のsodium/potassium-ATPase阻害剤で、同時に一種の自食活性剤ですが、各種の心臓律動異常の治療に使用されます。

S1344

Glimepiride

Glimepiride is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg.

S1160

TRAM-34

TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM.

S1426

Repaglinide

Repaglinide is for the treatment of type II diabetes.

S2502

Quinine HCl Dihydrate

Quinine hydrochloride dihydrate is a natural white crystalline alkaloid having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), anti-inflammatory properties and a bitter taste.

S1716

Glyburide (Glibenclamide)

Glyburide (Glibenclamide) is an anti-diabetic compound in a class of medications known as sulfonylureas, closely related to sulfa agents.

S2443

Tolbutamide

タイプ2糖尿病を治療するために、トルブタミドがダイエットと運動とともに、そして、時々他の薬物で使われます

S2114

Dronedarone HCl

Dronedarone HCl is a therapy for the treatment of patients with paroxysmal and persistent atrial fibrillation or atrial flutter.

S2489

Nateglinide

Nateglinide is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas.

S8016

Vonoprazan Fumarate (TAK-438)

Vonoprazan Fumarate (TAK-438)は、抗分泌性新しいカリウム競争的酸性のブロッカー(P-CAB)タイプですエージェント、可逆的に胃H+、K+-ATPaseを妨げます。IC50 が 19 nM 、 pH 6.5です。

S2825

ML133 HCl

ML133 HCl is a potent potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5).

S2601

Gliclazide

Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 ¡À 30 nM

S4037

Doxapram HCl

Doxapram HClはTASK-1, TASK-3, TASK-1/TASK-3 のヘテロチャネル機能を阻害、 EC50 がそれぞれ410 nM、 37 μM、 9 μMです。

S2073

Mitiglinide Calcium

Mitiglinide Calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.

S3151

Gliquidone

Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM.

S4733

Retigabine

S4734

Retigabine 2HCl

S1971

Nicorandil

Nicorandil is potassium channel activator.

S2562

Hydralazine HCl

Hydralazine hydrochloride is a hydrochloride salt of hydralazine (Apresoline) that is a direct-acting smooth muscle relaxant with an IC50 of 1.9 mM.

S4630

Diazoxide

S4632

Hexachlorophene

製品コード 製品説明 文献中の使用例 お客様のフィードバック
S1658

Dofetilide

Dofetilide(Tikosyn) is a class III antiarrhythmic agent.

S2456

Chlorpromazine HCl

Chlorpromazine HCl is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for nward-rectifying K+ currents and time-independent outward currents

S1979

Amiodarone HCl

Amiodarone HClは一種のsodium/potassium-ATPase阻害剤で、同時に一種の自食活性剤ですが、各種の心臓律動異常の治療に使用されます。

S1344

Glimepiride

Glimepiride is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg.

S1160

TRAM-34

TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM.

S1426

Repaglinide

Repaglinide is for the treatment of type II diabetes.

S2502

Quinine HCl Dihydrate

Quinine hydrochloride dihydrate is a natural white crystalline alkaloid having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), anti-inflammatory properties and a bitter taste.

S1716

Glyburide (Glibenclamide)

Glyburide (Glibenclamide) is an anti-diabetic compound in a class of medications known as sulfonylureas, closely related to sulfa agents.

S2443

Tolbutamide

タイプ2糖尿病を治療するために、トルブタミドがダイエットと運動とともに、そして、時々他の薬物で使われます

S2114

Dronedarone HCl

Dronedarone HCl is a therapy for the treatment of patients with paroxysmal and persistent atrial fibrillation or atrial flutter.

S2489

Nateglinide

Nateglinide is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas.

S8016

Vonoprazan Fumarate (TAK-438)

Vonoprazan Fumarate (TAK-438)は、抗分泌性新しいカリウム競争的酸性のブロッカー(P-CAB)タイプですエージェント、可逆的に胃H+、K+-ATPaseを妨げます。IC50 が 19 nM 、 pH 6.5です。

S2825

ML133 HCl

ML133 HCl is a potent potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5).

S2601

Gliclazide

Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 ¡À 30 nM

S4037

Doxapram HCl

Doxapram HClはTASK-1, TASK-3, TASK-1/TASK-3 のヘテロチャネル機能を阻害、 EC50 がそれぞれ410 nM、 37 μM、 9 μMです。

S2073

Mitiglinide Calcium

Mitiglinide Calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.

製品コード 製品説明 文献中の使用例 お客様のフィードバック
S4733

Retigabine

S4734

Retigabine 2HCl

S1971

Nicorandil

Nicorandil is potassium channel activator.

2016, 10.1177/1074248416636477

2017, 7(1):3156

S2562

Hydralazine HCl

Hydralazine hydrochloride is a hydrochloride salt of hydralazine (Apresoline) that is a direct-acting smooth muscle relaxant with an IC50 of 1.9 mM.

2014, 44(9):827-41

S4630

Diazoxide

S4632

Hexachlorophene

製品コード 製品説明 文献中の使用例 お客様のフィードバック
S3151

Gliquidone

Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM.