Docetaxel

製品コードS1148 別名:RP56976, NSC 628503

Docetaxel化学構造

分子量(MW):807.88

Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.

サイズ 価格(税別)  
JPY 15106.00
JPY 11620.00
JPY 44820.00

カスタマーフィードバック(5)

  • Viability of cells after exposure to 0, 10, or 10,000 nM docetaxel, assessed by calcein-AM staining (green, left panels) and ethidium homodimer-1 (red, middle panels).

    Mol Pharmaceutics, 2014, 11: 2040−50. Docetaxel purchased from Selleck.

    TNBC and non-TNBC cells were treated for 6 d with the specified concentrations of docetaxel (doc) alone, TTK inhibitor (TTKi) alone or the combinations. The survival of cells was measured using the MTS/MTA assay. ***P<0.001 comparing the combination with single agents and with non-TNBC cell lines.

    Oncogenesis, 2014, 3: e100 . Docetaxel purchased from Selleck.

  • J Transl Med 2013 0.6. Docetaxel purchased from Selleck.

    J Transl Med 2013 0.6. Docetaxel purchased from Selleck.

  • Cell cycle study of percent cell populations in various phases after treatment with vehicle, HCI-2509 in increasing concentrations and docetaxel alone and in combination with HCI-2509 using (a) PC3 cells. Student's unpaired t-tests, using GraphPad Prism software, were used to calculate two-tailed P-values for each experiment to determine statistical significance between untreated and treated samples. The statistically significant P-values are labeled in each figure with an asterisk. (Replicated two more times, representative graph shown).

    Prostate Cancer Prostatic Dis, 2016, 19(4):349-357. Docetaxel purchased from Selleck.

製品安全説明書

Microtubule Associated阻害剤の選択性比較

生物活性

製品説明 Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
ターゲット
Microtubules [1]
(Cell-free assay)
体外試験

Docetaxel is a cytotoxic agent, especially for proliferating cells, which is related to its ability to promote the formation of microtubule bundles and induce sustained mitotic arrest, followed by apoptosis of mitotically arrested cells or permanent mitotic block. Docetaxel suppresses microtubule dynamic instability as well as tread-milling, resulting in the failure of chromosomes to segregate to the daughter cells, which in turn triggers premature exit from mitosis rather than a block at this phase of the cell cycle. [2] Docetaxel inhibits the clonogenic survival of Human cancer cell Hs746T (stomach), AGS (stomach), HeLa (cervix), CaSki (cervix), BxPC3 (pancreas), Capan-1 (pancreas) with IC50 of 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM and 0.3 nM respectively. [4] Docetaxel inhibits endothelial cell migration that does not affects microtubule gross morphology or inhibit cell proliferation, although they does produce more subtle effects on microtubule dynamics. Docetaxel inhibits HUVEC migration with an observed IC50 of 1 pM. HUVEC chemotaxis stimulated by either of two angiogenic factors, thymidine phosphorylase or VEGF, is inhibited by Docetaxel with IC 50 of 10 pM and is ablated at 1 nM. [7] Docetaxel induces human monocytes, but not RAW 264.7 murine macrophages, Prostaglandin H Synthase-2m (PGHS-2) expression. [8]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HSC-3 MljLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1K0UWlEPTB;MD6wNFAyOzJizszN MV;TRW5ITVJ?
5637 NE\vVW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPXSYhiUUN3ME2wMlAxODF2MzFOwG0> M3fIdXNCVkeHUh?=
HT-144 M1vHUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7sTWM2OD1yLkCwNFE2PyEQvF2= M{TUO3NCVkeHUh?=
NCI-H292 M4LER2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2qzdGlEPTB;MD6wNFAyPTlizszN MXjTRW5ITVJ?
HCE-T NWC0PWZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzkfWFKSzVyPUCuNFAxOTZ{IN88US=> NGfGN5dUSU6JRWK=
ESS-1 NEmwUYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVroR3RKUUN3ME2wMlAxODF5OTFOwG0> NHnY[ZBUSU6JRWK=
D-566MG M4i0e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMECwNVgzKM7:TR?= NWP1TlA{W0GQR1XS
CAL-62 M3PMXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\LTWM2OD1yLkCwNFE5PSEQvF2= NXXEXnRuW0GQR1XS
GT3TKB M{\jdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknRTWM2OD1yLkCwNFI{OiEQvF2= MljjV2FPT0WU
HSC-4 NH3mbWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwMECwNlM6KM7:TR?= NIj3R4hUSU6JRWK=
KOSC-2 NIG3UYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGT5TVBKSzVyPUCuNFAxOjV3IN88US=> NGrhbmFUSU6JRWK=
NB14 MnTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmj2TWM2OD1yLkCwNFI3KM7:TR?= M3;BcnNCVkeHUh?=
ES8 NXLYbpFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrsN2xGUUN3ME2wMlAxODJ4IN88US=> NFf4bnRUSU6JRWK=
BFTC-905 MnjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjCTWM2OD1yLkCwNFI3QCEQvF2= MVLTRW5ITVJ?
A498 NEfjNI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DFW2lEPTB;MD6wNFAzPzhizszN MWXTRW5ITVJ?
HO-1-N-1 NFTSfIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWf4T2lVUUN3ME2wMlAxODJ6MTFOwG0> MYHTRW5ITVJ?
SF539 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMECwN|AzKM7:TR?= NUPsPWVbW0GQR1XS
HuO-3N1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\0PXNKSzVyPUCuNFAxOzB{IN88US=> MYjTRW5ITVJ?
NCI-H510A Mn3rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDyTWM2OD1yLkCwNFM{PiEQvF2= M4jqbXNCVkeHUh?=
CAL-27 NWO5[nUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rhcWlEPTB;MD6wNFA{OzlizszN NES4[HFUSU6JRWK=
TE-8 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nhdGlEPTB;MD6wNFA{PjZizszN NEntfVBUSU6JRWK=
VA-ES-BJ MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{e4bGlEPTB;MD6wNFA{PzVizszN MXTTRW5ITVJ?
RH-1 M2XIZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwMECwN|g3KM7:TR?= MXnTRW5ITVJ?
COLO-800 NWH2NVh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHW3Um5KSzVyPUCuNFAxOzh6IN88US=> M2XWOXNCVkeHUh?=
ES7 NF3YblJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMECwN|g6KM7:TR?= M4DVcnNCVkeHUh?=
GAMG NX3WOZJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TSdWlEPTB;MD6wNFA1OTZizszN MYnTRW5ITVJ?
Ca9-22 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnCWYJ1UUN3ME2wMlAxODR{MzFOwG0> MYPTRW5ITVJ?
SBC-1 NF;nS3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\uOnpKSzVyPUCuNFAxPDNizszN M37BNXNCVkeHUh?=
RPMI-7951 NVTmTGZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jWNWlEPTB;MD6wNFA1PDhizszN MU\TRW5ITVJ?
SW1710 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3ETWM2OD1yLkCwNFQ3PiEQvF2= MVXTRW5ITVJ?
HGC-27 M{nB[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rifmlEPTB;MD6wNFA1PzFizszN MnXOV2FPT0WU
MC-IXC NI[zOo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMECwOFc6KM7:TR?= NWH3eW5ZW0GQR1XS
FTC-133 NHrROJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwMECwOFg6KM7:TR?= MljuV2FPT0WU
HT-1080 NIHtWY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXrWVZ6UUN3ME2wMlAxODVyMTFOwG0> Mn32V2FPT0WU
NMC-G1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlT0TWM2OD1yLkCwNFUyPyEQvF2= MWHTRW5ITVJ?
GI-1 NWj0RWs4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMECwOVI5KM7:TR?= MVPTRW5ITVJ?
CGTH-W-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMECwOVQzKM7:TR?= MVXTRW5ITVJ?
A2058 M2\pPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fzV2lEPTB;MD6wNFA2PDRizszN M3TSV3NCVkeHUh?=
ETK-1 NWLTcmNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrQTWM2OD1yLkCwNFU2QCEQvF2= NH\3Z2FUSU6JRWK=
NEC8 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXNTWM2OD1yLkCwNFU3OSEQvF2= M1P5O3NCVkeHUh?=
TE-11 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4n0WGlEPTB;MD6wNFA2PjlizszN M1XGNnNCVkeHUh?=
NCI-H720 NGn4eJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlW1TWM2OD1yLkCwNFU5KM7:TR?= M{mzUXNCVkeHUh?=
PSN1 NXL6S4RrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnriTWM2OD1yLkCwNFU5OSEQvF2= NXT2W3doW0GQR1XS
SW780 M{\sdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGC1PHdKSzVyPUCuNFAxPTh5IN88US=> NHPhWGNUSU6JRWK=
8-MG-BA MnvWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwMECwOVg6KM7:TR?= M4\vdnNCVkeHUh?=
EC-GI-10 M2LWPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlv1TWM2OD1yLkCwNFU6OiEQvF2= NIi1eHlUSU6JRWK=
SJSA-1 M33Xfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfPdXBYUUN3ME2wMlAxODZzNTFOwG0> NFfadmNUSU6JRWK=
639-V MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDydYtKSzVyPUCuNFAxPjR5IN88US=> NFjocmRUSU6JRWK=
PFSK-1 NWjHT3kyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTkTWM2OD1yLkCwNFY2PyEQvF2= NV6weG1{W0GQR1XS
DMS-273 NYrBOGlkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlm0TWM2OD1yLkCwNFY4PCEQvF2= MVrTRW5ITVJ?
TE-9 M4HnSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMECwOlc3KM7:TR?= MUnTRW5ITVJ?
SCC-25 NIPHXFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwMECwOlgh|ryP MVPTRW5ITVJ?
PA-1 NX3vbIFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;pTWM2OD1yLkCwNFY5PyEQvF2= M2jFfHNCVkeHUh?=
MHH-ES-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPqOldKSzVyPUCuNFAxPyEQvF2= NGrC[GpUSU6JRWK=
Daoy M4GwdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;OfFNKSzVyPUCuNFAxPyEQvF2= NGf5R5hUSU6JRWK=
G-402 NHi3eXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLpXJJKSzVyPUCuNFAxPzB4IN88US=> MnHWV2FPT0WU
YKG-1 NX\NdnA4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3UcGZ6UUN3ME2wMlAxODdyNzFOwG0> Mmi4V2FPT0WU
Ca-Ski M4rlWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXZUmlKSzVyPUCuNFAxPzJ6IN88US=> M3e0NHNCVkeHUh?=
CHP-212 M2PqO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnCTWM2OD1yLkCwNFc{KM7:TR?= MYnTRW5ITVJ?
SCC-4 NIToeJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1e2VGlEPTB;MD6wNFA4OzlizszN NEXIbmJUSU6JRWK=
EW-3 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMECwO|Q2KM7:TR?= NH7FO49USU6JRWK=
P12-ICHIKAWA MmPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPYTWM2OD1yLkCwNFc1PSEQvF2= NHvnfXFUSU6JRWK=
HSC-2 MoPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XYXWlEPTB;MD6wNFA4PTVizszN MmD3V2FPT0WU
HN M4fIfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMECwO|U5KM7:TR?= Mkj0V2FPT0WU
LXF-289 Mm\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3rUIdtUUN3ME2wMlAxODd3ODFOwG0> MXjTRW5ITVJ?
ES1 NGG5cYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLBTWM2OD1yLkCwNFc4KM7:TR?= NYnsfXdXW0GQR1XS
NTERA-S-cl-D1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXuXVQ4UUN3ME2wMlAxODd5MzFOwG0> Mk\wV2FPT0WU
K5 NImwZ2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;TV2lEPTB;MD6wNFA4PzhizszN MULTRW5ITVJ?
HOS M4TKOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvocXFKSzVyPUCuNFAxPzh{IN88US=> NY\ES4dbW0GQR1XS
YH-13 MmGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\HRWhKSzVyPUCuNFAxPzlzIN88US=> M4jjZnNCVkeHUh?=
SW954 NV3kUmNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnr1TWM2OD1yLkCwNFgzOyEQvF2= M3m1Z3NCVkeHUh?=
KYSE-510 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XvbmlEPTB;MD6wNFA5PCEQvF2= NYTLb3BRW0GQR1XS
8505C NF3BT|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7yTWM2OD1yLkCwNFg2PCEQvF2= NULCXY9qW0GQR1XS
A549 Mn3RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXP2foV7UUN3ME2wMlAxODh6MjFOwG0> NIHlfmdUSU6JRWK=
Detroit562 NHnkbZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLzTWM2OD1yLkCwNFkxOiEQvF2= MWDTRW5ITVJ?
ES5 MlzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEn3OWZKSzVyPUCuNFAxQTFizszN M{PUfXNCVkeHUh?=
KYSE-140 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjjN3JKSzVyPUCuNFAxQTN|IN88US=> MXzTRW5ITVJ?
GMS-10 MoSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13EVGlEPTB;MD6wNFA6PDFizszN M{HvSXNCVkeHUh?=
D-263MG NWq0d2hwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfVTmFKSzVyPUCuNFAxQTR5IN88US=> MXHTRW5ITVJ?
BCPAP M3[1PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjP[|BKSzVyPUCuNFAxQTR5IN88US=> MXrTRW5ITVJ?
CHL-1 NY\tSHM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMECwPVU5KM7:TR?= NXy2[GtYW0GQR1XS
RKO MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMECwPVg6KM7:TR?= NUnqfm0xW0GQR1XS
SW48 Mn7DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTCTWM2OD1yLkCwNVAyKM7:TR?= M1XuS3NCVkeHUh?=
BPH-1 NIjPXGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjXTmlKSzVyPUCuNFAyODJizszN MWXTRW5ITVJ?
EFO-27 NXfDe482T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVL2O5hsUUN3ME2wMlAxOTB{IN88US=> M4\zU3NCVkeHUh?=
CAL-33 NV3ON3FOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrlemJKSzVyPUCuNFAyODRizszN NX;kcZJtW0GQR1XS
NCI-H1792 NH3vW2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFL6UlVKSzVyPUCuNFAyODRizszN NEPY[ZJUSU6JRWK=
BB30-HNC MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrpb3drUUN3ME2wMlAxOTB3IN88US=> M3m3cnNCVkeHUh?=
VM-CUB-1 M{jsUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HjNWlEPTB;MD6wNFExPSEQvF2= NIqxT4JUSU6JRWK=
TE-5 Mn7kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fxcWlEPTB;MD6wNFExPiEQvF2= NGO2cWFUSU6JRWK=
NB13 NH7UfItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjZTWM2OD1yLkCwNVA4KM7:TR?= Mnm3V2FPT0WU
NBsusSR NH24bZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3GUIFKSzVyPUCuNFAyOSEQvF2= NX7vUHBQW0GQR1XS
LNCaP-Clone-FGC MnXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwMECxNUDPxE1? MmLuV2FPT0WU
EPLC-272H NIf3RppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrSPYFRUUN3ME2wMlAxOTFzIN88US=> MmXkV2FPT0WU
KNS-62 M1r0d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3S1e2lEPTB;MD6wNFEyOiEQvF2= M{mxbnNCVkeHUh?=
RERF-LC-MS NIr1Vo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwMECxNVMh|ryP Mo[1V2FPT0WU
LOXIMVI NFmzUVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zkV2lEPTB;MD6wNFEyPiEQvF2= NW\nPWpvW0GQR1XS
KINGS-1 NEXLWnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\yTWM2OD1yLkCwNVE4KM7:TR?= MW\TRW5ITVJ?
T98G NUjpS3hqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwMECxNVch|ryP M1jLbXNCVkeHUh?=
HCC1806 MoP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PWTmlEPTB;MD6wNFEyQCEQvF2= NWG5PHBvW0GQR1XS
MZ1-PC M3r5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;vTWM2OD1yLkCwNVE5KM7:TR?= MoHxV2FPT0WU
RT-112 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnZO21yUUN3ME2wMlAxOTF7IN88US=> M2Tp[HNCVkeHUh?=
LK-2 NVvKXYpkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwMECxNlEh|ryP NYfLOnNDW0GQR1XS
A375 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHH6[mhKSzVyPUCuNFAyOjFizszN NUf1WFlCW0GQR1XS
SF268 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\We3RKSzVyPUCuNFAyOjFizszN NYTjXYtSW0GQR1XS
H9 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2D2T2lEPTB;MD6wNFEzPCEQvF2= MUnTRW5ITVJ?
KYSE-410 Mnn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLNTWM2OD1yLkCwNVI1KM7:TR?= Mm\DV2FPT0WU
G-401 M3T3ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH:2c2VKSzVyPUCuNFAyOjdizszN MW\TRW5ITVJ?
SW982 M3vpXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMECxNlch|ryP MX;TRW5ITVJ?
D-423MG MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3zNGdKSzVyPUCuNFAyOyEQvF2= M2LpXXNCVkeHUh?=
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SAS MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrBfJpFUUN3ME2wMlAxOTN2IN88US=> NYD1cYM4W0GQR1XS
KYSE-180 NWKwTHJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfadGd7UUN3ME2wMlAxOTN3IN88US=> Ml7IV2FPT0WU
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KYSE-450 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfMTWM2OD1yLkCwNVQ{KM7:TR?= Mn7iV2FPT0WU
LCLC-97TM1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPFcVRKSzVyPUCuNFAyPDRizszN NIXoNJNUSU6JRWK=
KS-1 MljWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMECxOFQh|ryP NFfodHVUSU6JRWK=
TI-73 NFT2THlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfHTWM2OD1yLkCwNVQ1KM7:TR?= M4\vXHNCVkeHUh?=
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PANC-03-27 NIrpT4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTBwMECxOVQh|ryP MkDIV2FPT0WU
23132-87 Mn7BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nBV2lEPTB;MD6wNFE2PSEQvF2= MWHTRW5ITVJ?
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KP-4 NHjofYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMECxOVYh|ryP NHvnTWRUSU6JRWK=
NCI-H1703 M4DNfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrVTWM2OD1yLkCwNVU4KM7:TR?= NGr0WZRUSU6JRWK=
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A172 M{j5NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLpTWM2OD1yLkCwNVY{KM7:TR?= MV\TRW5ITVJ?
CAL-39 M2\hXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\hcZVIUUN3ME2wMlAxOTZ|IN88US=> M3HvbnNCVkeHUh?=
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D-336MG M17pV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGX1b|RKSzVyPUCuNFAyPjlizszN MWfTRW5ITVJ?
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SK-MEL-2 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnQWXZKSzVyPUCuNFAyPyEQvF2= M2HqeHNCVkeHUh?=
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EoL-1-cell MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TVR2lEPTB;MD6wNFE4OyEQvF2= MmWzV2FPT0WU
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U-2-OS NETEOVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDXTWM2OD1yLkCwNVc2KM7:TR?= M17xOnNCVkeHUh?=
NCI-H526 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXz4XoQxUUN3ME2wMlAxOTd4IN88US=> MmP2V2FPT0WU
SK-NEP-1 Mn;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTaTWM2OD1yLkCwNVc3KM7:TR?= NHHjOmNUSU6JRWK=
DB NIDWOWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLXUZFKSzVyPUCuNFAyPzhizszN MkXFV2FPT0WU
GCT NYHoNGsyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwMECxPEDPxE1? MXfTRW5ITVJ?
HCT-116 NWfzfHU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Hj[2lEPTB;MD6wNFE5OSEQvF2= M1K1VnNCVkeHUh?=
AU565 MnL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXhdYVjUUN3ME2wMlAxOThzIN88US=> Mne5V2FPT0WU
KALS-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXSxOHNCUUN3ME2wMlAxOThzIN88US=> MWjTRW5ITVJ?
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Becker MkTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMECxPFMh|ryP M2Hqd3NCVkeHUh?=
647-V MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnoWnpKSzVyPUCuNFAyQDRizszN MoDIV2FPT0WU
NCI-H2122 M2jrdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVr3RY01UUN3ME2wMlAxOTh2IN88US=> M1vTOnNCVkeHUh?=
SBC-5 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2q0OGlEPTB;MD6wNFE5PyEQvF2= NXv1U|JtW0GQR1XS
NB17 M3Tudmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmmxTWM2OD1yLkCwNVg6KM7:TR?= Mn[2V2FPT0WU
MHH-PREB-1 M4fqTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHVUXZKSzVyPUCuNFAyQDlizszN MVzTRW5ITVJ?
M14 MkfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mon3TWM2OD1yLkCwNVkyKM7:TR?= NUCyS4dMW0GQR1XS
NCI-H1048 NVvDclZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLDdZNmUUN3ME2wMlAxOTl{IN88US=> MorzV2FPT0WU
CTB-1 MorHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XleGlEPTB;MD6wNFE6OiEQvF2= MlfmV2FPT0WU
SK-PN-DW M{S2fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{KxeWlEPTB;MD6wNFE6PCEQvF2= M{Pqd3NCVkeHUh?=
H4 MmW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwMECxPVYh|ryP M{\JV3NCVkeHUh?=
NCI-SNU-1 Mmn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwMECxPVch|ryP Ml;OV2FPT0WU
M059J MlvNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\qTWM2OD1yLkCwNVk5KM7:TR?= MnvHV2FPT0WU
OVCAR-5 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMECxPVkh|ryP M{npT3NCVkeHUh?=
SK-MEL-28 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGKwdWtKSzVyPUCuNFAzODNizszN NYT0XlJnW0GQR1XS
PC-14 NWjmRoxNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7qSmM5UUN3ME2wMlAxOjB7IN88US=> MofRV2FPT0WU
OVCAR-8 M{HhZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnSxTWM2OD1yLkCwNlEzKM7:TR?= M1i5OHNCVkeHUh?=
BB49-HNC NITodWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvHc5lKSzVyPUCuNFAzOTJizszN MYHTRW5ITVJ?
EFM-19 NWr6RpdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLHOYNKSzVyPUCuNFAzOTVizszN NEDqdXVUSU6JRWK=
BHY Mm\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrNOFIzUUN3ME2wMlAxOjF4IN88US=> Ml7jV2FPT0WU
SW756 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwMECyNVYh|ryP NFHPWXJUSU6JRWK=
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NCI-H2452 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfPTWM2OD1yLkCwNlE3KM7:TR?= NHm5RopUSU6JRWK=
NCI-H1581 NIHaO2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnsfY1KSzVyPUCuNFAzOTdizszN NHu1SFVUSU6JRWK=
COR-L23 MmKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPlco9KSzVyPUCuNFAzOiEQvF2= MVPTRW5ITVJ?
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BFTC-909 NIm0U41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwMECyNlUh|ryP MUTTRW5ITVJ?
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NCI-H650 M4XHWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPuTWM2OD1yLkCwNlI2KM7:TR?= NXvubYdsW0GQR1XS
SK-UT-1 MnXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3e2RmlEPTB;MD6wNFIzPiEQvF2= M3;zdnNCVkeHUh?=
GOTO NXSwTWpOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHOxbHRKSzVyPUCuNFAzOjdizszN NXnpe5d[W0GQR1XS
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JVM-3 M1T6[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TQNWlEPTB;MD6wNFI{OyEQvF2= NIHJempUSU6JRWK=
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RPMI-2650 M2HYWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELPN2lKSzVyPUCuNFAzPDZizszN MWfTRW5ITVJ?
HCE-4 Mo\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTMTWM2OD1yLkCwNlQ4KM7:TR?= NG\UTGFUSU6JRWK=
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CAL-51 MlzHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TKXGlEPTB;MD6wNFI4OSEQvF2= M4DmO3NCVkeHUh?=
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MDA-MB-415 MmT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLWSIVKSzVyPUCuNFAzPzRizszN MkOwV2FPT0WU
SW1417 NWXF[294T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUT6cW5PUUN3ME2wMlAxOjd4IN88US=> MXPTRW5ITVJ?
HCC70 NGL1fpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jUOGlEPTB;MD6wNFI4PyEQvF2= MoXJV2FPT0WU
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KYSE-270 MkX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHrbHFzUUN3ME2wMlAxOjd6IN88US=> NUni[HpFW0GQR1XS
HT-29 M4rENmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rmbmlEPTB;MD6wNFI5KM7:TR?= MnLwV2FPT0WU
MDA-MB-361 M1;GZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Txd2lEPTB;MD6wNFI5OSEQvF2= NXT4O25vW0GQR1XS
RPMI-8866 Mnj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUftPZZWUUN3ME2wMlAxOjhzIN88US=> M4K2d3NCVkeHUh?=
JEG-3 NFfQ[nZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjnWXBGUUN3ME2wMlAxOjh{IN88US=> MoHlV2FPT0WU
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NCI-H209 NUTwOGJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkn1TWM2OD1yLkCwNlg3KM7:TR?= MVrTRW5ITVJ?
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LCLC-103H NXTYOoZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDGUGpKSzVyPUCuNFAzQTNizszN NFS1SlVUSU6JRWK=
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SW1088 MnfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFK0bmxKSzVyPUCuNFAzQTVizszN MUnTRW5ITVJ?
GP5d MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HRPGlEPTB;MD6wNFI6PiEQvF2= NY\YTZBiW0GQR1XS
EW-1 Ml7sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH21TndKSzVyPUCuNFAzQThizszN NXLEVmFuW0GQR1XS
CP66-MEL MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMECzJO69VQ>? NV3Te4xiW0GQR1XS
DEL M323dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnS5TWM2OD1yLkCwN|AyKM7:TR?= MYDTRW5ITVJ?
DU-4475 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nyZWlEPTB;MD6wNFMxOiEQvF2= MmH2V2FPT0WU
HEC-1 NYnSR29MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnG4TWM2OD1yLkCwN|A{KM7:TR?= NXvkeHBtW0GQR1XS
U031 MkTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PhUGlEPTB;MD6wNFMxPyEQvF2= MWPTRW5ITVJ?
BB65-RCC MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTrb5lwUUN3ME2wMlAxOzB6IN88US=> M{L2fnNCVkeHUh?=
NUGC-3 Mn[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\pemlEPTB;MD6wNFMxQCEQvF2= NHLFNZdUSU6JRWK=
IST-SL1 M2K3SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHSTWM2OD1yLkCwN|EzKM7:TR?= M13YNnNCVkeHUh?=
LS-411N MmH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nCeWlEPTB;MD6wNFMyPCEQvF2= NVLYW|JtW0GQR1XS
22RV1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HUWGlEPTB;MD6wNFMyPSEQvF2= NYPZd2hSW0GQR1XS
MKN28 NHX6c4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwMECzNVch|ryP MYrTRW5ITVJ?
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NB6 M3XwfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLFb4lKSzVyPUCuNFM6PTJizszN NGXhfGJUSU6JRWK=
HT NHzoV4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfSTWM2OD1yLkC0NFA4KM7:TR?= NIPPT2tUSU6JRWK=
COLO-684 NHLHZZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrQ[HRuUUN3ME2wMlA1ODl3IN88US=> NH\wdnBUSU6JRWK=
NCI-H1693 MoHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrFbVVKSzVyPUCuNFQ{ODVizszN NU\YXZJqW0GQR1XS
LAN-6 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV34Z3hKUUN3ME2wMlA1OzN3IN88US=> M1rjOXNCVkeHUh?=
MDA-MB-175-VII NYjYbldVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NESwV3RKSzVyPUCuNFQ1OTdizszN MmThV2FPT0WU
KMOE-2 NWXuZXZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfW[HhjUUN3ME2wMlA1PDZ7IN88US=> NE[2UHFUSU6JRWK=
DMS-79 MmPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIj2OJJKSzVyPUCuNFQ2PzlizszN NVPBO3FYW0GQR1XS
MHH-NB-11 NX\peWNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwMES2NVQh|ryP MUTTRW5ITVJ?
NCI-H69 NYTLN2pMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnTOJhKSzVyPUCuNFQ5PDlizszN M{TZd3NCVkeHUh?=
KE-37 NXHnV3A6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwMEWwNUDPxE1? MmfBV2FPT0WU
Ramos-2G6-4C10 MmG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzZTWM2OD1yLkC1NFY4KM7:TR?= NYrCbnBrW0GQR1XS
NCI-H1793 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nMSmlEPTB;MD6wOVA6OyEQvF2= M13zT3NCVkeHUh?=
HT-1376 Ml3TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnMVXdKSzVyPUCuNFUyQDZizszN Mm\DV2FPT0WU
EKVX NFP4Xm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnyZmNoUUN3ME2wMlA2Ozh2IN88US=> NUXTc4hEW0GQR1XS
Capan-2 NFTEcmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\kcolKSzVyPUCuNFU{QTZizszN M1vaV3NCVkeHUh?=
DoTc2-4510 NHXVVJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPLPYNKSzVyPUCuNFU1PDZizszN MV;TRW5ITVJ?
UACC-893 Mn2xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTy[nZpUUN3ME2wMlA2PDZ{IN88US=> MmPJV2FPT0WU
SK-MEL-3 NHjDdWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPmSlhKSzVyPUCuNFU4QDhizszN NVXjNIZQW0GQR1XS
SK-MEL-1 NGrnb5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMEW4JO69VQ>? M{PLdnNCVkeHUh?=
SW948 MlLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvWTWM2OD1yLkC1PVk3KM7:TR?= M{ixcXNCVkeHUh?=
P30-OHK NYrFV5JvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjKfIZKSzVyPUCuNFYyPjdizszN NY\pWJBZW0GQR1XS
NH-12 NVr3TXYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\Mb4ZKSzVyPUCuNFYzPDRizszN NHTIPVlUSU6JRWK=
KU-19-19 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfNWolvUUN3ME2wMlA3OzZzIN88US=> MoXjV2FPT0WU
A431 Mm\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEC2OnpKSzVyPUCuNFY{PzRizszN MXzTRW5ITVJ?
NCI-H2405 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHrWm9iUUN3ME2wMlA3Ozh|IN88US=> MVrTRW5ITVJ?
KARPAS-299 M{\qOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwME[1PFIh|ryP NELZWFBUSU6JRWK=
BALL-1 MkTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PieGlEPTB;MD6wOlY4PCEQvF2= MULTRW5ITVJ?
KURAMOCHI NWXNcXFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwMEewO|Mh|ryP NH7lcHZUSU6JRWK=
LS-1034 Mlv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMEezOlkh|ryP M1j0R3NCVkeHUh?=
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HOP-62 M17nb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzLSGJ1UUN3ME2wMlA4Pjd4IN88US=> Mlq0V2FPT0WU
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CW-2 M33B[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwMEe4N|Ih|ryP M3i2WHNCVkeHUh?=
SW837 MkDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\hTWM2OD1yLkC4N|QzKM7:TR?= NXHHbZNzW0GQR1XS
MFH-ino M{Tremdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3j0c2lEPTB;MD6wPFUxOSEQvF2= MlLLV2FPT0WU
HCC1419 NEXjeYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwMEi5PFch|ryP NIjscmpUSU6JRWK=
HMV-II M1[xNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkG4TWM2OD1yLkC5NFEh|ryP NWjsenRsW0GQR1XS
BEN M3i2[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnKTWM2OD1yLkC5N|g2KM7:TR?= MlTHV2FPT0WU
SK-N-FI MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjFXG5KSzVyPUCuNFk2PTZizszN NGe2TlVUSU6JRWK=
JVM-2 NWfWPIdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnzTWM2OD1yLkC5O|E3KM7:TR?= MkLNV2FPT0WU
CAL-54 M3TSdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMUCwOEDPxE1? NGi0eWJUSU6JRWK=
T84 M4Xudmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLVTWM2OD1yLkGwPVUzKM7:TR?= MXvTRW5ITVJ?
SHP-77 NUPsPJF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzXe5hqUUN3ME2wMlEyPjRzIN88US=> MkLQV2FPT0WU
G-361 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DT[2lEPTB;MD6xNlMzPCEQvF2= MUfTRW5ITVJ?
Calu-3 NH\nbYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfnZmpVUUN3ME2wMlE{QDF4IN88US=> MX\TRW5ITVJ?
HCC1937 Ml7uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFj0fGxKSzVyPUCuNVQ6OzdizszN MknqV2FPT0WU
KM-H2 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;pdWtKSzVyPUCuNVUxOSEQvF2= MWnTRW5ITVJ?
769-P M12yTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjlXVRPUUN3ME2wMlE2QDR|IN88US=> NIfjWI5USU6JRWK=
NCI-H1304 NGHHV5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3oTWM2OD1yLkG2NFYyKM7:TR?= MluxV2FPT0WU
D-542MG Mlf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMU[yO|gh|ryP MX3TRW5ITVJ?
ATN-1 M3nGV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTHZXZIUUN3ME2wMlE4PDRzIN88US=> M4LxenNCVkeHUh?=
NCI-H2029 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwMkCyOFMh|ryP NHnPRldUSU6JRWK=
ZR-75-30 M1HaSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PzVmlEPTB;MD6yNFY1OyEQvF2= NVnNVZpwW0GQR1XS
SW1116 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1ru[mlEPTB;MD6yNVEyPyEQvF2= MXnTRW5ITVJ?
CCRF-CEM MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33ZV2lEPTB;MD6yO|YyPCEQvF2= M3;ab3NCVkeHUh?=
LU-135 Mn3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwMke3N|kh|ryP MVzTRW5ITVJ?
MC116 NILqUIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4ns[WlEPTB;MD6yPFMxQSEQvF2= MWfTRW5ITVJ?
LS-513 MmXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnLTWM2OD1yLkK4O|c{KM7:TR?= NHnafmxUSU6JRWK=
NCI-H630 M2jPbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{POT2lEPTB;MD6yPVM4PiEQvF2= MWPTRW5ITVJ?
L-428 NWnzRmJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMkm4PFMh|ryP NHvvdZVUSU6JRWK=
UM-UC-3 NI\ON3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwM{GyPVEh|ryP MYXTRW5ITVJ?
NCI-H1838 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPve|VKSzVyPUCuN|E4QDRizszN M1XY[nNCVkeHUh?=
HEL M3eyTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mki0TWM2OD1yLkOyNlQh|ryP NUnHW3J3W0GQR1XS
OCI-AML2 NHnR[|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFiyXlRKSzVyPUCuN|IzQThizszN NUT1Om8xW0GQR1XS
A3-KAW M4Ppe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\TbFRRUUN3ME2wMlM{PDd5IN88US=> MlvyV2FPT0WU
IGROV-1 M3e2bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHq2U2FKSzVyPUCuN|M4PTVizszN Ml\DV2FPT0WU
Mo-T NIW2[JBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;jU2lEPTB;MD6zN|g2OyEQvF2= NIG2dZZUSU6JRWK=
HDLM-2 NWj4VnllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHFZlkzUUN3ME2wMlM{QSEQvF2= MYfTRW5ITVJ?
HCC1569 MnzRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInJe5VKSzVyPUCuN|Q{ODlizszN M1\XU3NCVkeHUh?=
COLO-678 NHfZbWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwM{ewNFIh|ryP NUjI[oFxW0GQR1XS
COR-L105 MoLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\rTWM2OD1yLkO3PVMh|ryP MojwV2FPT0WU
SK-MEL-24 MnrNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfMSYZkUUN3ME2wMlM5Ozh{IN88US=> MUfTRW5ITVJ?
COLO-320-HSR MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDNTWM2OD1yLkSzPVc3KM7:TR?= M1Pvc3NCVkeHUh?=
C8166 MoDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjiTWM2OD1yLkS5NFI{KM7:TR?= NYm2N5M{W0GQR1XS
COLO-679 NV7LZ3o5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1X1[2lEPTB;MD62NlE4OiEQvF2= MXvTRW5ITVJ?
TE-12 NXKzb|JZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvGbJNKSzVyPUCuOlU{QTRizszN M4nS[3NCVkeHUh?=
HAL-01 M2m0U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVX3TYV2UUN3ME2wMlY3OjJizszN Mor6V2FPT0WU
H-EMC-SS MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWP2NGRWUUN3ME2wMlcxPTR4IN88US=> MXvTRW5ITVJ?
SNU-449 NInCVItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2j0dGlEPTB;MD63Nlc1QCEQvF2= M3q2d3NCVkeHUh?=
C32 NYrseFBXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHyTWM2OD1yLke0NVEzKM7:TR?= M4LTSXNCVkeHUh?=
K-562 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjifIlKSzVyPUCuO|cxOjRizszN MV\TRW5ITVJ?
DJM-1 M1vWb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fteGlEPTB;MD63PFc5OSEQvF2= MnvGV2FPT0WU
RCC10RGB NEjvNJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIK0O4xKSzVyPUCuO|kyQDNizszN Mk\SV2FPT0WU
CAL-85-1 NIKzdXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DObGlEPTB;MD65NFch|ryP M1nieXNCVkeHUh?=
NY NEDreGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHSdVhKSzVyPUCuPVM{PTJizszN MV7TRW5ITVJ?
NCI-H1993 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoOxTWM2OD1zLkG5Nlg6KM7:TR?= MVXTRW5ITVJ?
SK-OV-3 NILhUHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXf2ZmoxUUN3ME2xMlIzODh7IN88US=> NEjmdHZUSU6JRWK=

多くの細胞株試験データを見る場合、クリックしてください

体内試験 Docetaxel (33 mg/kg/dose, given i.v. every 4 days for 3 injections) results in a tumor growth delay of 19.3 days in M2OL2 colon xenografts. Docetaxel also shows great antitumor activities in MX-1, SK-MEL-2, LX-1 and OVCAR-3 xenografts. Docetaxel inhibits the angiogenic response to fibroblast growth factor 2 with IC 50 of 5.4 mg/kg when injected twice weekly over a 14-day period, and angiogenesis is completely blocked in mice that receives 10 mg/kg Docetaxel. Docetaxel has selectivity for endothelial cell migration and/or microvessel formation because infiltration of inflammatory cells into the Matrigel plug is much less sensitive to inhibition by Docetaxel. [7]

お薦めの試験操作(参考用のみ)

細胞試験: [5]
+ 展開
  • 細胞株: Human gastric cancer cell lines MKN-28
  • 濃度: 6 nM
  • 反応時間: 3 days
  • 実験の流れ: 2000 cells in 180 μL of medium are seeded in a 96-well plate, and 20 μL of drug solution is simultaneously added in triplicate to each well. The plate is incubated for 3 days at 37°C in a humidified atmosphere of 5% CO2. On day 3, 25 μL of MTT reagent is added to each well. After 4 h of incubation, the medium is removed by aspiration. 0.2 mL of dimethylsulphoxide (DMSO) is added to each well and thoroughly mixed by using a mechanical plate mixer to dissolve the resulting MTT-formazan crystals. Absorbance at 540 nm (OD) is measured by a reader.
    (参考用のみ)
動物試験:[6]
+ 展開
  • 動物モデル: Human colon carcinomas xenografts CX-1
  • 製剤: 50 mg/mL stock solution in ethanol by adding an equal volume of polysorbate 80 and diluting with 5% dextrose in water to the final volume
  • 投薬量: 33 mg/kg
  • 投与方法: i.v. every 4 days for 3 injections
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 100 mg/mL (123.78 mM)
Ethanol 53 mg/mL warmed (65.6 mM)
Water Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます:
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
混合させたのち直ちに使用することを推奨します。
2mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 807.88
化学式

C43H53NO14

CAS No. 114977-28-5
保管
in solvent
別名 RP56976, NSC 628503

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02124902 Recruiting Triple Negative Breast Neoplasms Washington University School of Medicine July 7, 2014 Phase 2
NCT01683994 Recruiting Prostatic Neoplasms National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) September 6, 2012 Phase 1|Phase 2
NCT02649855 Recruiting Prostate Cancer|Prostate Neoplasms|Neoplasms, Prostatic National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) January 4, 2016 Phase 2
NCT03041181 Recruiting Non-Squamous Non-Small Cell Lung Cancer (NSCLC)|Adenocarcinoma of the Lung|Lung Cancer Nasser Hanna, M.D.|Hoosier Cancer Research Network|Bristol-Myers Squibb January 27, 2017 Phase 2
NCT00251433 Active, not recruiting Neoplasms, Breast Novartis Pharmaceuticals|Novartis September 26, 2005 Phase 1
NCT01907529 Not yet recruiting Stage III Breast Cancer Hebei Medical University Fourth Hospital August 2018 Phase 2|Phase 3

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

Microtubule Associatedシグナル伝達経路

相関Microtubule Associated製品

Tags: Docetaxelを買う | Docetaxel ic50 | Docetaxel供給者 | Docetaxelを購入する | Docetaxel費用 | Docetaxel生産者 | オーダーDocetaxel | Docetaxel化学構造 | Docetaxel分子量 | Docetaxel代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID