Docetaxel

製品コードS1148 別名:RP56976, NSC 628503

Docetaxel化学構造

分子量(MW):807.88

Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.

サイズ 価格(税別)  
JPY 15106.00
JPY 11620.00
JPY 44820.00

カスタマーフィードバック(5)

  • Viability of cells after exposure to 0, 10, or 10,000 nM docetaxel, assessed by calcein-AM staining (green, left panels) and ethidium homodimer-1 (red, middle panels).

    Mol Pharmaceutics, 2014, 11: 2040−50. Docetaxel purchased from Selleck.

    TNBC and non-TNBC cells were treated for 6 d with the specified concentrations of docetaxel (doc) alone, TTK inhibitor (TTKi) alone or the combinations. The survival of cells was measured using the MTS/MTA assay. ***P<0.001 comparing the combination with single agents and with non-TNBC cell lines.

    Oncogenesis, 2014, 3: e100 . Docetaxel purchased from Selleck.

  • J Transl Med 2013 0.6. Docetaxel purchased from Selleck.

    J Transl Med 2013 0.6. Docetaxel purchased from Selleck.

  • Cell cycle study of percent cell populations in various phases after treatment with vehicle, HCI-2509 in increasing concentrations and docetaxel alone and in combination with HCI-2509 using (a) PC3 cells. Student's unpaired t-tests, using GraphPad Prism software, were used to calculate two-tailed P-values for each experiment to determine statistical significance between untreated and treated samples. The statistically significant P-values are labeled in each figure with an asterisk. (Replicated two more times, representative graph shown).

    Prostate Cancer Prostatic Dis, 2016, 19(4):349-357. Docetaxel purchased from Selleck.

製品安全説明書

Microtubule Associated阻害剤の選択性比較

生物活性

製品説明 Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
ターゲット
Microtubules [1]
(Cell-free assay)
体外試験

Docetaxel is a cytotoxic agent, especially for proliferating cells, which is related to its ability to promote the formation of microtubule bundles and induce sustained mitotic arrest, followed by apoptosis of mitotically arrested cells or permanent mitotic block. Docetaxel suppresses microtubule dynamic instability as well as tread-milling, resulting in the failure of chromosomes to segregate to the daughter cells, which in turn triggers premature exit from mitosis rather than a block at this phase of the cell cycle. [2] Docetaxel inhibits the clonogenic survival of Human cancer cell Hs746T (stomach), AGS (stomach), HeLa (cervix), CaSki (cervix), BxPC3 (pancreas), Capan-1 (pancreas) with IC50 of 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM and 0.3 nM respectively. [4] Docetaxel inhibits endothelial cell migration that does not affects microtubule gross morphology or inhibit cell proliferation, although they does produce more subtle effects on microtubule dynamics. Docetaxel inhibits HUVEC migration with an observed IC50 of 1 pM. HUVEC chemotaxis stimulated by either of two angiogenic factors, thymidine phosphorylase or VEGF, is inhibited by Docetaxel with IC 50 of 10 pM and is ablated at 1 nM. [7] Docetaxel induces human monocytes, but not RAW 264.7 murine macrophages, Prostaglandin H Synthase-2m (PGHS-2) expression. [8]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HSC-3 NIj2RoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\ZW4VKSzVyPUCuNFAxOTN{IN88US=> M4XkZXNCVkeHUh?=
5637 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjaU2VKSzVyPUCuNFAxOTR|IN88US=> MVzTRW5ITVJ?
HT-144 NFP4T|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGW4W3BKSzVyPUCuNFAxOTV5IN88US=> M4TyOXNCVkeHUh?=
NCI-H292 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMECwNVU6KM7:TR?= MlXFV2FPT0WU
HCE-T Mn6xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWf1WWJUUUN3ME2wMlAxODF4MjFOwG0> NInMPJhUSU6JRWK=
ESS-1 MkG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMECwNVc6KM7:TR?= M4DOOXNCVkeHUh?=
D-566MG NYXoeJRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnkU3ZRUUN3ME2wMlAxODF6MjFOwG0> NHjYNm9USU6JRWK=
CAL-62 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{n5OGlEPTB;MD6wNFAyQDVizszN Ml3CV2FPT0WU
GT3TKB M{G0[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfJTWM2OD1yLkCwNFI{OiEQvF2= M4H3W3NCVkeHUh?=
HSC-4 NYHNcmtET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUf1NoZbUUN3ME2wMlAxODJ|OTFOwG0> MXzTRW5ITVJ?
KOSC-2 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDTSJVVUUN3ME2wMlAxODJ3NTFOwG0> MYHTRW5ITVJ?
NB14 M1THWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLMOJVKSzVyPUCuNFAxOjZizszN MUXTRW5ITVJ?
ES8 M1e3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTRTWM2OD1yLkCwNFI3KM7:TR?= NG\Xb25USU6JRWK=
BFTC-905 NX:5cpFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nEbGlEPTB;MD6wNFAzPjhizszN Mn7UV2FPT0WU
A498 M3vWbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVSzZmh{UUN3ME2wMlAxODJ5ODFOwG0> NXy4WWw3W0GQR1XS
HO-1-N-1 M37tc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwMECwNlgyKM7:TR?= MkLxV2FPT0WU
SF539 NGHFZXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnmzTWM2OD1yLkCwNFMxOiEQvF2= MWLTRW5ITVJ?
HuO-3N1 M1;UNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmW1TWM2OD1yLkCwNFMxOiEQvF2= MXzTRW5ITVJ?
NCI-H510A M3K0UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17EbWlEPTB;MD6wNFA{OzZizszN MoLxV2FPT0WU
CAL-27 NVnGdIQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMECwN|M6KM7:TR?= MV\TRW5ITVJ?
TE-8 NWTOS3k{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rJeGlEPTB;MD6wNFA{PjZizszN M3;kcXNCVkeHUh?=
VA-ES-BJ MofrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjTPVdMUUN3ME2wMlAxODN5NTFOwG0> M3PHSnNCVkeHUh?=
RH-1 NH7Wc2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI[weFNKSzVyPUCuNFAxOzh4IN88US=> M4X4UXNCVkeHUh?=
COLO-800 NGHCfZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwMECwN|g5KM7:TR?= M1\ITXNCVkeHUh?=
ES7 NGnnPHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LnOmlEPTB;MD6wNFA{QDlizszN Mm\hV2FPT0WU
GAMG NXK2OoVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDuPFdKSzVyPUCuNFAxPDF4IN88US=> NHqwbpNUSU6JRWK=
Ca9-22 NV;3XVZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvlTms{UUN3ME2wMlAxODR{MzFOwG0> NISxVoNUSU6JRWK=
SBC-1 NWHPdI5NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwMECwOFMh|ryP M4PNc3NCVkeHUh?=
RPMI-7951 M4i0PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwMECwOFQ5KM7:TR?= NUfUem1ZW0GQR1XS
SW1710 NEPQO|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nTfGlEPTB;MD6wNFA1PjZizszN M1zaWXNCVkeHUh?=
HGC-27 NXzU[XF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTLUHBQUUN3ME2wMlAxODR5MTFOwG0> M3u4OXNCVkeHUh?=
MC-IXC Mli2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTSdpJiUUN3ME2wMlAxODR5OTFOwG0> NX[wN2JFW0GQR1XS
FTC-133 NELETJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMECwOFg6KM7:TR?= M4eyOnNCVkeHUh?=
HT-1080 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HSd2lEPTB;MD6wNFA2ODFizszN M2HuRnNCVkeHUh?=
NMC-G1 NH7ibppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TP[mlEPTB;MD6wNFA2OTdizszN MnrPV2FPT0WU
GI-1 MlPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWT3Z2VIUUN3ME2wMlAxODV{ODFOwG0> M3;FdHNCVkeHUh?=
CGTH-W-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTxTWM2OD1yLkCwNFU1OiEQvF2= Mn7hV2FPT0WU
A2058 MlG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTpb3ZHUUN3ME2wMlAxODV2NDFOwG0> MYHTRW5ITVJ?
ETK-1 NHz3U|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\zVnZKSzVyPUCuNFAxPTV6IN88US=> M4K4[nNCVkeHUh?=
NEC8 NWHCeml{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;FO2lEPTB;MD6wNFA2PjFizszN M1;4UHNCVkeHUh?=
TE-11 NXfHUZVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMECwOVY6KM7:TR?= MkPzV2FPT0WU
NCI-H720 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XRdGlEPTB;MD6wNFA2QCEQvF2= NXHMPGxWW0GQR1XS
PSN1 MojhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofZTWM2OD1yLkCwNFU5OSEQvF2= NEiyVHFUSU6JRWK=
SW780 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnWxTWM2OD1yLkCwNFU5PyEQvF2= NV3OOJd6W0GQR1XS
8-MG-BA NV7XUVFST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMECwOVg6KM7:TR?= MXzTRW5ITVJ?
EC-GI-10 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jqUmlEPTB;MD6wNFA2QTJizszN M4rDN3NCVkeHUh?=
SJSA-1 MnOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMECwOlE2KM7:TR?= M3jMRXNCVkeHUh?=
639-V MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMECwOlQ4KM7:TR?= MmX5V2FPT0WU
PFSK-1 NULx[G1TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwMECwOlU4KM7:TR?= MYnTRW5ITVJ?
DMS-273 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrPdJBiUUN3ME2wMlAxODZ5NDFOwG0> NGHaSnZUSU6JRWK=
TE-9 NWXiVVRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwMECwOlc3KM7:TR?= NHjZe5pUSU6JRWK=
SCC-25 M3HMcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHJeHJLUUN3ME2wMlAxODZ6IN88US=> NXuyWHpMW0GQR1XS
PA-1 M2P0PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fYS2lEPTB;MD6wNFA3QDdizszN NYTwW4R6W0GQR1XS
MHH-ES-1 NIfDe5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjsTWM2OD1yLkCwNFch|ryP NYfqTXZkW0GQR1XS
Daoy Mn\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fMc2lEPTB;MD6wNFA4KM7:TR?= MmTuV2FPT0WU
G-402 NHTlW5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2faU2lEPTB;MD6wNFA4ODZizszN NEXJR|JUSU6JRWK=
YKG-1 NH3GS29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7KeYZCUUN3ME2wMlAxODdyNzFOwG0> NVfGU4xuW0GQR1XS
Ca-Ski Ml;LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjBS25ZUUN3ME2wMlAxODd{ODFOwG0> MVrTRW5ITVJ?
CHP-212 NX:3e4RFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\vVVhKSzVyPUCuNFAxPzNizszN NYDEeWZUW0GQR1XS
SCC-4 M4\1Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Tje2lEPTB;MD6wNFA4OzlizszN NVP2PVVWW0GQR1XS
EW-3 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;QTWM2OD1yLkCwNFc1PSEQvF2= NWLRTIFWW0GQR1XS
P12-ICHIKAWA MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHCTWM2OD1yLkCwNFc1PSEQvF2= MXTTRW5ITVJ?
HSC-2 NVTzc4hXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXETWM2OD1yLkCwNFc2PSEQvF2= MlvjV2FPT0WU
HN NUjYUI5ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMECwO|U5KM7:TR?= MkTzV2FPT0WU
LXF-289 M4rMfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3jUG1KSzVyPUCuNFAxPzV6IN88US=> M{GxN3NCVkeHUh?=
ES1 MnHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3W2b2lEPTB;MD6wNFA4PyEQvF2= NVu2UVNpW0GQR1XS
NTERA-S-cl-D1 NYnhdW1yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{myVmlEPTB;MD6wNFA4PzNizszN MXjTRW5ITVJ?
K5 NGnyVVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnhU3ZKSzVyPUCuNFAxPzd6IN88US=> MV\TRW5ITVJ?
HOS Mm\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDRTWM2OD1yLkCwNFc5OiEQvF2= MWTTRW5ITVJ?
YH-13 M1G4SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjYe2hKSzVyPUCuNFAxPzlzIN88US=> MVPTRW5ITVJ?
SW954 M2Pvd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fiSWlEPTB;MD6wNFA5OjNizszN NHG1XoxUSU6JRWK=
KYSE-510 MmHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jRbmlEPTB;MD6wNFA5PCEQvF2= NHnDToxUSU6JRWK=
8505C Mn32S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\wTIxUUUN3ME2wMlAxODh3NDFOwG0> M{\TVHNCVkeHUh?=
A549 M2rM[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\rWmlEPTB;MD6wNFA5QDJizszN MVLTRW5ITVJ?
Detroit562 NXOxZYhyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDETlRKSzVyPUCuNFAxQTB{IN88US=> NULlcmVGW0GQR1XS
ES5 MlTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmC3TWM2OD1yLkCwNFkyKM7:TR?= MWDTRW5ITVJ?
KYSE-140 M1TwVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPESVdKSzVyPUCuNFAxQTN|IN88US=> NFzpSlVUSU6JRWK=
GMS-10 NWrpfW1oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwMECwPVQyKM7:TR?= NYLRepRoW0GQR1XS
D-263MG MoX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDp[GJqUUN3ME2wMlAxODl2NzFOwG0> NWLCU2x7W0GQR1XS
BCPAP MnX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrvbFFKSzVyPUCuNFAxQTR5IN88US=> NHXsVYpUSU6JRWK=
CHL-1 MmnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrVUYtKSzVyPUCuNFAxQTV6IN88US=> NXi3d5FyW0GQR1XS
RKO NX;5NHJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TUS2lEPTB;MD6wNFA6QDlizszN NV;zO4lPW0GQR1XS
SW48 M1jzfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXhTWM2OD1yLkCwNVAyKM7:TR?= Mn7hV2FPT0WU
BPH-1 NGm0ZYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwMECxNFIh|ryP MVjTRW5ITVJ?
EFO-27 MlrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwMECxNFIh|ryP MXzTRW5ITVJ?
CAL-33 NWTBT3QzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfXXZhVUUN3ME2wMlAxOTB2IN88US=> NFnSUFhUSU6JRWK=
NCI-H1792 NXjO[2o5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMECxNFQh|ryP NWrqU3d5W0GQR1XS
BB30-HNC NF3DflRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHT4eIRKSzVyPUCuNFAyODVizszN M{DSO3NCVkeHUh?=
VM-CUB-1 NF;5RlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwMECxNFUh|ryP M4HiZ3NCVkeHUh?=
TE-5 NUnub3lJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjwUIF3UUN3ME2wMlAxOTB4IN88US=> MUPTRW5ITVJ?
NB13 NGj1PWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjXcpNKSzVyPUCuNFAyODdizszN MXHTRW5ITVJ?
NBsusSR MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLtTWM2OD1yLkCwNVEh|ryP Mn\iV2FPT0WU
LNCaP-Clone-FGC NVL4[3BNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwMECxNUDPxE1? NYrRT3l[W0GQR1XS
EPLC-272H MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\nWlhnUUN3ME2wMlAxOTFzIN88US=> MkjDV2FPT0WU
KNS-62 NXvZR|F6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMECxNVIh|ryP M2LT[nNCVkeHUh?=
RERF-LC-MS MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DQPGlEPTB;MD6wNFEyOyEQvF2= Mn\QV2FPT0WU
LOXIMVI M2OweGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXWTWM2OD1yLkCwNVE3KM7:TR?= MnjVV2FPT0WU
KINGS-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwMECxNVch|ryP NVP4XnNZW0GQR1XS
T98G MmHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPPSJlKSzVyPUCuNFAyOTdizszN MYHTRW5ITVJ?
HCC1806 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HOUWlEPTB;MD6wNFEyQCEQvF2= Ml30V2FPT0WU
MZ1-PC M4G0b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDzVZBKSzVyPUCuNFAyOThizszN NI\CUWlUSU6JRWK=
RT-112 M3v5eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnF[XJKSzVyPUCuNFAyOTlizszN NYHTR4oyW0GQR1XS
LK-2 NWTabZcyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVuwU5l4UUN3ME2wMlAxOTJzIN88US=> NWfnNmZ[W0GQR1XS
A375 Mn7NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7ETWM2OD1yLkCwNVIyKM7:TR?= NXTBWHFCW0GQR1XS
SF268 NUfTVolJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULTfmxSUUN3ME2wMlAxOTJzIN88US=> MUPTRW5ITVJ?
H9 MkDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX[3XmY4UUN3ME2wMlAxOTJ2IN88US=> NILDfolUSU6JRWK=
KYSE-410 Mn7DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHO2OGxKSzVyPUCuNFAyOjRizszN NHPoUI9USU6JRWK=
G-401 MmS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nIbWlEPTB;MD6wNFEzPyEQvF2= NHjl[W9USU6JRWK=
SW982 MljCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUi0ZmMxUUN3ME2wMlAxOTJ5IN88US=> NUThNHIyW0GQR1XS
D-423MG M1vWSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXoTWM2OD1yLkCwNVMh|ryP MlHqV2FPT0WU
CAMA-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULWZok2UUN3ME2wMlAxOTNzIN88US=> Mkj6V2FPT0WU
SCC-9 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;MO2sxUUN3ME2wMlAxOTN{IN88US=> Mmn1V2FPT0WU
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KYSE-450 M17KXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHkTWM2OD1yLkCwNVQ{KM7:TR?= NF[3OHJUSU6JRWK=
LCLC-97TM1 NWrrO|V1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULj[nB{UUN3ME2wMlAxOTR2IN88US=> MlvEV2FPT0WU
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TI-73 MnnyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moi4TWM2OD1yLkCwNVQ1KM7:TR?= MXHTRW5ITVJ?
A427 NGS5emhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwMECxOFgh|ryP M{XwW3NCVkeHUh?=
LB831-BLC MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2n3[2lEPTB;MD6wNFE1QCEQvF2= M{fv[3NCVkeHUh?=
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A172 MoHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;w[VVKSzVyPUCuNFAyPjNizszN NX\R[pJMW0GQR1XS
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DB M{HMOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LFdGlEPTB;MD6wNFE4QCEQvF2= M3fsSXNCVkeHUh?=
GCT NYTZOGRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwMECxPEDPxE1? MnjKV2FPT0WU
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H4 M{PWfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMECxPVYh|ryP NGniVVRUSU6JRWK=
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M059J M4rRZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnflTWM2OD1yLkCwNVk5KM7:TR?= NWm4SIdDW0GQR1XS
OVCAR-5 Mk\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMECxPVkh|ryP MXXTRW5ITVJ?
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PC-14 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMECyNFkh|ryP MnzoV2FPT0WU
OVCAR-8 M2nZemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvlNJJKSzVyPUCuNFAzOTJizszN MYrTRW5ITVJ?
BB49-HNC MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfUUHVmUUN3ME2wMlAxOjF{IN88US=> NEfj[HNUSU6JRWK=
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BHY MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\OcGtIUUN3ME2wMlAxOjF4IN88US=> MWjTRW5ITVJ?
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BFTC-909 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;sUItlUUN3ME2wMlAxOjJ3IN88US=> NXT3WJUxW0GQR1XS
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NCI-H650 NXX5SHJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVP5RmpqUUN3ME2wMlAxOjJ3IN88US=> MXHTRW5ITVJ?
SK-UT-1 NFXuSZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYj5T5BUUUN3ME2wMlAxOjJ4IN88US=> NICzblBUSU6JRWK=
GOTO M3nIVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHnTWM2OD1yLkCwNlI4KM7:TR?= NF3nTIhUSU6JRWK=
TYK-nu MmPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDlbZd7UUN3ME2wMlAxOjN{IN88US=> NEL2OmRUSU6JRWK=
JVM-3 MnTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;JRo5KSzVyPUCuNFAzOzNizszN MUHTRW5ITVJ?
SK-MES-1 NIXVeW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVO3PJJTUUN3ME2wMlAxOjN|IN88US=> NVroSIZYW0GQR1XS
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A673 NHrQ[HNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrZ[49tUUN3ME2wMlAxOjN3IN88US=> MnHGV2FPT0WU
NCI-H446 NUO2c3VRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfFXnNvUUN3ME2wMlAxOjR|IN88US=> MkLHV2FPT0WU
RPMI-2650 M3XTeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTkWpV2UUN3ME2wMlAxOjR4IN88US=> M4XRcnNCVkeHUh?=
HCE-4 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1[zcmlEPTB;MD6wNFI1PyEQvF2= M{nreHNCVkeHUh?=
KGN MoTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLoTWM2OD1yLkCwNlQ4KM7:TR?= M1PWSHNCVkeHUh?=
U251 NXjv[JB3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwMECyOUDPxE1? NVLNR4dVW0GQR1XS
BxPC-3 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTyZYJwUUN3ME2wMlAxOjVzIN88US=> MVLTRW5ITVJ?
VMRC-RCZ MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjXeZZKSzVyPUCuNFAzPTJizszN NEnZZ4NUSU6JRWK=
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OC-314 MmHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml72TWM2OD1yLkCwNlU3KM7:TR?= NXvnWJdOW0GQR1XS
NCI-H1437 M{f1c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFP6dZFKSzVyPUCuNFAzPiEQvF2= NVnheXg5W0GQR1XS
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A388 M2DVWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTvV|dPUUN3ME2wMlAxOjZ3IN88US=> MUHTRW5ITVJ?
C-33-A NX6weZVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fycWlEPTB;MD6wNFI3PiEQvF2= NF\kNVdUSU6JRWK=
CAL-51 NXv0SJRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW[0fVBZUUN3ME2wMlAxOjdzIN88US=> NGDYd2JUSU6JRWK=
Hs-578-T MlrvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPqfYxLUUN3ME2wMlAxOjd{IN88US=> NF:xU|hUSU6JRWK=
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SW1417 MlzCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4ewVmlEPTB;MD6wNFI4PiEQvF2= M3SzVnNCVkeHUh?=
HCC70 NHP6WolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTiTpZqUUN3ME2wMlAxOjd5IN88US=> MYjTRW5ITVJ?
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KYSE-270 MlXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PWdWlEPTB;MD6wNFI4QCEQvF2= M3LWSXNCVkeHUh?=
HT-29 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHtPWZKSzVyPUCuNFAzQCEQvF2= M3H2OXNCVkeHUh?=
MDA-MB-361 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMECyPFEh|ryP NV[5[o4xW0GQR1XS
RPMI-8866 M13MSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4KyTWlEPTB;MD6wNFI5OSEQvF2= NEXwbWtUSU6JRWK=
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HT-3 M4GwfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmOyTWM2OD1yLkCwNlgzKM7:TR?= MmG1V2FPT0WU
HTC-C3 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFq2d5RKSzVyPUCuNFAzQDVizszN MoK5V2FPT0WU
NCI-H209 MoPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;0XJh4UUN3ME2wMlAxOjh4IN88US=> MnfQV2FPT0WU
SKG-IIIa M3P6RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMECyPFYh|ryP NX\Id2J5W0GQR1XS
SW962 MljVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XEVmlEPTB;MD6wNFI6OyEQvF2= MYDTRW5ITVJ?
LCLC-103H MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLvdIxMUUN3ME2wMlAxOjl|IN88US=> MX;TRW5ITVJ?
DOK MoXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMECyPVQh|ryP NH\ZU5pUSU6JRWK=
SW1088 NHjhbmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml70TWM2OD1yLkCwNlk2KM7:TR?= M1XZbHNCVkeHUh?=
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CP66-MEL NFf1bodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMECzJO69VQ>? MljMV2FPT0WU
DEL MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHSS|lKSzVyPUCuNFA{ODFizszN M4\LcXNCVkeHUh?=
DU-4475 M3G4NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrue3liUUN3ME2wMlAxOzB{IN88US=> MVLTRW5ITVJ?
HEC-1 M{O3S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMECzNFMh|ryP NYXVXmZIW0GQR1XS
U031 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HwZWlEPTB;MD6wNFMxPyEQvF2= M{\LR3NCVkeHUh?=
BB65-RCC NVz4VWpFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELJPYVKSzVyPUCuNFA{ODhizszN M17jcHNCVkeHUh?=
NUGC-3 NEnDTJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjrdopNUUN3ME2wMlAxOzB6IN88US=> MUXTRW5ITVJ?
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LS-411N MnKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV75W3JZUUN3ME2wMlAxOzF2IN88US=> NGjLd5ZUSU6JRWK=
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TGBC11TKB NEjnTYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwMEC0Olkh|ryP M{[4NHNCVkeHUh?=
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NCI-H1651 NIO0N|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk[5TWM2OD1yLkCwOVQh|ryP M3TDXnNCVkeHUh?=
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MMAC-SF NUPCfppRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULyfJhTUUN3ME2wMlAxPTh4IN88US=> M2TiPXNCVkeHUh?=
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DOHH-2 Mnv2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIW1VHFKSzVyPUCuNFA3OyEQvF2= MX\TRW5ITVJ?
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COLO-829 NV;McW41T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIO2cllKSzVyPUCuNFA4OjVizszN MorSV2FPT0WU
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NCI-H2087 M1Hje2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMEC3OFgh|ryP MWPTRW5ITVJ?
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NCI-H358 MlHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;qTWM2OD1yLkCwO|U5KM7:TR?= NVXLXo9mW0GQR1XS
NCI-H2126 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFW2fFBKSzVyPUCuNFA4PzNizszN MmHwV2FPT0WU
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COLO-668 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMEO4PFch|ryP MojrV2FPT0WU
LU-65 NVvwV2RJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwMEO5NFQh|ryP MWXTRW5ITVJ?
NB6 M3z2Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIT1cZpKSzVyPUCuNFM6PTJizszN NH7hTWpUSU6JRWK=
HT M1\KcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;rTWM2OD1yLkC0NFA4KM7:TR?= NXT1WJpUW0GQR1XS
COLO-684 M1:5NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwMESwPVUh|ryP NXrpXmFkW0GQR1XS
NCI-H1693 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mne0TWM2OD1yLkC0N|A2KM7:TR?= M{fCWXNCVkeHUh?=
LAN-6 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofxTWM2OD1yLkC0N|M2KM7:TR?= NEG4cW5USU6JRWK=
MDA-MB-175-VII NWDTWplrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjI[oFKSzVyPUCuNFQ1OTdizszN Mnq2V2FPT0WU
KMOE-2 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPHS5llUUN3ME2wMlA1PDZ7IN88US=> NXTS[4lPW0GQR1XS
DMS-79 NV3WbVY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnO4TWM2OD1yLkC0OVc6KM7:TR?= NIS1RlJUSU6JRWK=
MHH-NB-11 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fUV2lEPTB;MD6wOFYyPCEQvF2= NHruR5pUSU6JRWK=
NCI-H69 NIO0OlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMES4OFkh|ryP M3jNNnNCVkeHUh?=
KE-37 M3;kfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHq5NXNKSzVyPUCuNFUxOSEQvF2= MnjCV2FPT0WU
Ramos-2G6-4C10 NE\xZnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\QTWM2OD1yLkC1NFY4KM7:TR?= MUHTRW5ITVJ?
NCI-H1793 MlHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXMTWM2OD1yLkC1NFk{KM7:TR?= NFPSUW5USU6JRWK=
HT-1376 M3ftRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnVXXNMUUN3ME2wMlA2OTh4IN88US=> NILrWoxUSU6JRWK=
EKVX M4Kwc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorjTWM2OD1yLkC1N|g1KM7:TR?= MVTTRW5ITVJ?
Capan-2 NIDQRXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwMEWzPVYh|ryP MXHTRW5ITVJ?
DoTc2-4510 NEXpNFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULsN3ZvUUN3ME2wMlA2PDR4IN88US=> NYHURoV5W0GQR1XS
UACC-893 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrwTWM2OD1yLkC1OFYzKM7:TR?= MWjTRW5ITVJ?
SK-MEL-3 NGS5SIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\zWGlEPTB;MD6wOVc5QCEQvF2= MX7TRW5ITVJ?
SK-MEL-1 NGPDe|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3W2NWlEPTB;MD6wOVgh|ryP NHLHSHdUSU6JRWK=
SW948 MljwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYr0[ppCUUN3ME2wMlA2QTl4IN88US=> NVrHd5dvW0GQR1XS
P30-OHK NXToZpU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rXZ2lEPTB;MD6wOlE3PyEQvF2= MUHTRW5ITVJ?
NH-12 M3TUSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwME[yOFQh|ryP M4nJWHNCVkeHUh?=
KU-19-19 MljzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DnSWlEPTB;MD6wOlM3OSEQvF2= M{W0VnNCVkeHUh?=
A431 M3fR[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmf1TWM2OD1yLkC2N|c1KM7:TR?= NGHtNXRUSU6JRWK=
NCI-H2405 MmfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn21TWM2OD1yLkC2N|g{KM7:TR?= NETGc4xUSU6JRWK=
KARPAS-299 NYTwNYwzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXPTWM2OD1yLkC2OVgzKM7:TR?= MoPaV2FPT0WU
BALL-1 NGfXdoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwME[2O|Qh|ryP MXzTRW5ITVJ?
KURAMOCHI M1TJUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHMTWM2OD1yLkC3NFc{KM7:TR?= NGL2cnFUSU6JRWK=
LS-1034 M364Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwMEezOlkh|ryP NH35elNUSU6JRWK=
MFE-280 NHPHdXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1[weGlEPTB;MD6wO|U{PiEQvF2= NHvwfVJUSU6JRWK=
HOP-62 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwMEe2O|Yh|ryP MkXOV2FPT0WU
KG-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDyNnRKSzVyPUCuNFc4QDdizszN M1;jPHNCVkeHUh?=
CW-2 NWfje4NHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDmPZNKSzVyPUCuNFc5OzJizszN NXizc3lpW0GQR1XS
SW837 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwMEizOFIh|ryP M1PnenNCVkeHUh?=
MFH-ino M1vqO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwMEi1NFEh|ryP NHr6fZdUSU6JRWK=
HCC1419 M{\NN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPyTWM2OD1yLkC4PVg4KM7:TR?= NIDOW21USU6JRWK=
HMV-II MlHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPhTWM2OD1yLkC5NFEh|ryP MnT5V2FPT0WU
BEN NXHUWWFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHDTWM2OD1yLkC5N|g2KM7:TR?= MoTVV2FPT0WU
SK-N-FI M2jUWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWToVWlsUUN3ME2wMlA6PTV4IN88US=> Mn\LV2FPT0WU
JVM-2 NFXpS3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwMEm3NVYh|ryP MVHTRW5ITVJ?
CAL-54 MoPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;yTWM2OD1yLkGwNFQh|ryP NYfsTYRHW0GQR1XS
T84 M3PuT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMUC5OVIh|ryP MlHGV2FPT0WU
SHP-77 M4LuRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjITWM2OD1yLkGxOlQyKM7:TR?= NXjRSoNrW0GQR1XS
G-361 NEXOcpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{KxbGlEPTB;MD6xNlMzPCEQvF2= NV:2U4RyW0GQR1XS
Calu-3 NF7Vc3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMUO4NVYh|ryP M3r2NXNCVkeHUh?=
HCC1937 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMUS5N|ch|ryP NFTHRlVUSU6JRWK=
KM-H2 M1e0dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEH1TpBKSzVyPUCuNVUxOSEQvF2= M2j3WnNCVkeHUh?=
769-P Ml[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnG5TWM2OD1yLkG1PFQ{KM7:TR?= NGfnXlRUSU6JRWK=
NCI-H1304 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMU[wOlEh|ryP NXnxWY83W0GQR1XS
D-542MG M4i1NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIn0XVZKSzVyPUCuNVYzPzhizszN NUnTNFdvW0GQR1XS
ATN-1 NWe2fnp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwMUe0OFEh|ryP M{\ZW3NCVkeHUh?=
NCI-H2029 MoToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMkCyOFMh|ryP MmLEV2FPT0WU
ZR-75-30 NWHmOI5KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwMkC2OFMh|ryP Mni2V2FPT0WU
SW1116 NVHNelZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwMkGxNVch|ryP MUfTRW5ITVJ?
CCRF-CEM MoPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwMke2NVQh|ryP MVvTRW5ITVJ?
LU-135 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMke3N|kh|ryP NInYclJUSU6JRWK=
MC116 M1f1dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXZUYJKSzVyPUCuNlg{ODlizszN MYPTRW5ITVJ?
LS-513 M4XDdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{L4bmlEPTB;MD6yPFc4OyEQvF2= MYjTRW5ITVJ?
NCI-H630 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{X0N2lEPTB;MD6yPVM4PiEQvF2= M1PvUHNCVkeHUh?=
L-428 NWjscog6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwMkm4PFMh|ryP MX;TRW5ITVJ?
UM-UC-3 Mn2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX60UY1IUUN3ME2wMlMyOjlzIN88US=> M37ofXNCVkeHUh?=
NCI-H1838 MoC5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEi5d5FKSzVyPUCuN|E4QDRizszN NYjKUHVGW0GQR1XS
HEL MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorGTWM2OD1yLkOyNlQh|ryP NILpOo5USU6JRWK=
OCI-AML2 M4ixZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjrTGNKSzVyPUCuN|IzQThizszN MlG1V2FPT0WU
A3-KAW MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4OwW2lEPTB;MD6zN|Q4PyEQvF2= NFToOpBUSU6JRWK=
IGROV-1 MnPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXX[FlKSzVyPUCuN|M4PTVizszN NVrMN|JvW0GQR1XS
Mo-T MoXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjLVYlKSzVyPUCuN|M5PTNizszN MXjTRW5ITVJ?
HDLM-2 NF7ZeolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLOOpZyUUN3ME2wMlM{QSEQvF2= M3f4c3NCVkeHUh?=
HCC1569 M1PTT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\1dmlEPTB;MD6zOFMxQSEQvF2= NFn6ZmZUSU6JRWK=
COLO-678 M4THS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDVV41YUUN3ME2wMlM4ODB{IN88US=> M3fsXHNCVkeHUh?=
COR-L105 M1r5dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnIVFdPUUN3ME2wMlM4QTNizszN NXvUfY02W0GQR1XS
SK-MEL-24 M1vLWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWm4XYVuUUN3ME2wMlM5Ozh{IN88US=> MkXOV2FPT0WU
COLO-320-HSR MlPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrqc4E3UUN3ME2wMlQ{QTd4IN88US=> MoD6V2FPT0WU
C8166 MkLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwNEmwNlMh|ryP NUHIdVBpW0GQR1XS
COLO-679 MnrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{n0OmlEPTB;MD62NlE4OiEQvF2= NYPrbocxW0GQR1XS
TE-12 MnOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHRRYJKSzVyPUCuOlU{QTRizszN MkfkV2FPT0WU
HAL-01 Ml7US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYmyPGFqUUN3ME2wMlY3OjJizszN M1nYc3NCVkeHUh?=
H-EMC-SS MkThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWX0TnExUUN3ME2wMlcxPTR4IN88US=> NWHLdXB4W0GQR1XS
SNU-449 M{LrOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\STWM2OD1yLkeyO|Q5KM7:TR?= MnP3V2FPT0WU
C32 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXKbm9KSzVyPUCuO|QyOTJizszN MkK2V2FPT0WU
K-562 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwN{ewNlQh|ryP M3ewb3NCVkeHUh?=
DJM-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwN{i3PFEh|ryP Mk\jV2FPT0WU
RCC10RGB MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILDeZBKSzVyPUCuO|kyQDNizszN MmSyV2FPT0WU
CAL-85-1 M{LaWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjrVWlKSzVyPUCuPVA4KM7:TR?= M1jCfXNCVkeHUh?=
NY MoK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2T6cGlEPTB;MD65N|M2OiEQvF2= M2nD[nNCVkeHUh?=
NCI-H1993 MmqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTFwMUmyPFkh|ryP Mn3WV2FPT0WU
SK-OV-3 NFjaO3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnsephKSzVyPUGuNlIxQDlizszN NVzHVHdYW0GQR1XS

多くの細胞株試験データを見る場合、クリックしてください

体内試験 Docetaxel (33 mg/kg/dose, given i.v. every 4 days for 3 injections) results in a tumor growth delay of 19.3 days in M2OL2 colon xenografts. Docetaxel also shows great antitumor activities in MX-1, SK-MEL-2, LX-1 and OVCAR-3 xenografts. Docetaxel inhibits the angiogenic response to fibroblast growth factor 2 with IC 50 of 5.4 mg/kg when injected twice weekly over a 14-day period, and angiogenesis is completely blocked in mice that receives 10 mg/kg Docetaxel. Docetaxel has selectivity for endothelial cell migration and/or microvessel formation because infiltration of inflammatory cells into the Matrigel plug is much less sensitive to inhibition by Docetaxel. [7]

お薦めの試験操作(参考用のみ)

細胞試験: [5]
+ 展開
  • 細胞株: Human gastric cancer cell lines MKN-28
  • 濃度: 6 nM
  • 反応時間: 3 days
  • 実験の流れ: 2000 cells in 180 μL of medium are seeded in a 96-well plate, and 20 μL of drug solution is simultaneously added in triplicate to each well. The plate is incubated for 3 days at 37°C in a humidified atmosphere of 5% CO2. On day 3, 25 μL of MTT reagent is added to each well. After 4 h of incubation, the medium is removed by aspiration. 0.2 mL of dimethylsulphoxide (DMSO) is added to each well and thoroughly mixed by using a mechanical plate mixer to dissolve the resulting MTT-formazan crystals. Absorbance at 540 nm (OD) is measured by a reader.
    (参考用のみ)
動物試験:[6]
+ 展開
  • 動物モデル: Human colon carcinomas xenografts CX-1
  • 製剤: 50 mg/mL stock solution in ethanol by adding an equal volume of polysorbate 80 and diluting with 5% dextrose in water to the final volume
  • 投薬量: 33 mg/kg
  • 投与方法: i.v. every 4 days for 3 injections
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 100 mg/mL (123.78 mM)
Ethanol 53 mg/mL warmed (65.6 mM)
Water Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます:
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
混合させたのち直ちに使用することを推奨します。
2mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 807.88
化学式

C43H53NO14

CAS No. 114977-28-5
保管
別名 RP56976, NSC 628503

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02124902 Recruiting Triple Negative Breast Neoplasms Washington University School of Medicine July 7, 2014 Phase 2
NCT01683994 Recruiting Prostatic Neoplasms National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) September 6, 2012 Phase 1|Phase 2
NCT02649855 Recruiting Prostate Cancer|Prostate Neoplasms|Neoplasms, Prostatic National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) January 4, 2016 Phase 2
NCT03041181 Recruiting Non-Squamous Non-Small Cell Lung Cancer (NSCLC)|Adenocarcinoma of the Lung|Lung Cancer Nasser Hanna, M.D.|Hoosier Cancer Research Network|Bristol-Myers Squibb January 27, 2017 Phase 2
NCT00251433 Active, not recruiting Neoplasms, Breast Novartis Pharmaceuticals|Novartis September 26, 2005 Phase 1
NCT01907529 Not yet recruiting Stage III Breast Cancer Hebei Medical University Fourth Hospital August 2018 Phase 2|Phase 3

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

Microtubule Associatedシグナル伝達経路

相関Microtubule Associated製品

Tags: Docetaxelを買う | Docetaxel ic50 | Docetaxel供給者 | Docetaxelを購入する | Docetaxel費用 | Docetaxel生産者 | オーダーDocetaxel | Docetaxel化学構造 | Docetaxel分子量 | Docetaxel代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID