Docetaxel

製品コードS1148 別名:RP56976, NSC 628503

Docetaxel化学構造

分子量(MW):807.88

Docetaxelは一種のtaxol類似物で、一種のマイクロチューブ解重合阻害剤ですが、安定なマイクロチューブと結合することを通じて、役立ちます。

サイズ 価格(税別) 在庫  
JPY 15106.00 あり
JPY 11620.00 あり
JPY 44820.00 あり

カスタマーフィードバック(5)

  • Viability of cells after exposure to 0, 10, or 10,000 nM docetaxel, assessed by calcein-AM staining (green, left panels) and ethidium homodimer-1 (red, middle panels).

    Mol Pharmaceutics, 2014, 11: 2040−50. Docetaxel purchased from Selleck.

    TNBC and non-TNBC cells were treated for 6 d with the specified concentrations of docetaxel (doc) alone, TTK inhibitor (TTKi) alone or the combinations. The survival of cells was measured using the MTS/MTA assay. ***P<0.001 comparing the combination with single agents and with non-TNBC cell lines.

    Oncogenesis, 2014, 3: e100 . Docetaxel purchased from Selleck.

  • J Transl Med 2013 0.6. Docetaxel purchased from Selleck.

    J Transl Med 2013 0.6. Docetaxel purchased from Selleck.

  • Cell cycle study of percent cell populations in various phases after treatment with vehicle, HCI-2509 in increasing concentrations and docetaxel alone and in combination with HCI-2509 using (a) PC3 cells. Student's unpaired t-tests, using GraphPad Prism software, were used to calculate two-tailed P-values for each experiment to determine statistical significance between untreated and treated samples. The statistically significant P-values are labeled in each figure with an asterisk. (Replicated two more times, representative graph shown).

    Prostate Cancer Prostatic Dis, 2016, 19(4):349-357. Docetaxel purchased from Selleck.

製品安全説明書

Microtubule Associated阻害剤の選択性比較

生物活性

製品説明 Docetaxelは一種のtaxol類似物で、一種のマイクロチューブ解重合阻害剤ですが、安定なマイクロチューブと結合することを通じて、役立ちます。
ターゲット
Microtubules [1]
(Cell-free assay)
体外試験

Docetaxel is a cytotoxic agent, especially for proliferating cells, which is related to its ability to promote the formation of microtubule bundles and induce sustained mitotic arrest, followed by apoptosis of mitotically arrested cells or permanent mitotic block. Docetaxel suppresses microtubule dynamic instability as well as tread-milling, resulting in the failure of chromosomes to segregate to the daughter cells, which in turn triggers premature exit from mitosis rather than a block at this phase of the cell cycle. [2] Docetaxel inhibits the clonogenic survival of Human cancer cell Hs746T (stomach), AGS (stomach), HeLa (cervix), CaSki (cervix), BxPC3 (pancreas), Capan-1 (pancreas) with IC50 of 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM and 0.3 nM respectively. [4] Docetaxel inhibits endothelial cell migration that does not affects microtubule gross morphology or inhibit cell proliferation, although they does produce more subtle effects on microtubule dynamics. Docetaxel inhibits HUVEC migration with an observed IC50 of 1 pM. HUVEC chemotaxis stimulated by either of two angiogenic factors, thymidine phosphorylase or VEGF, is inhibited by Docetaxel with IC 50 of 10 pM and is ablated at 1 nM. [7] Docetaxel induces human monocytes, but not RAW 264.7 murine macrophages, Prostaglandin H Synthase-2m (PGHS-2) expression. [8]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HSC-3 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTxSmNKSzVyPUCuNFAxOTN{IN88US=> M2WyfHNCVkeHUh?=
5637 NWfzUYEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXXVmFKSzVyPUCuNFAxOTR|IN88US=> M4L6N3NCVkeHUh?=
HT-144 M4Kye2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXn0eJhNUUN3ME2wMlAxODF3NzFOwG0> NVfRNG5YW0GQR1XS
NCI-H292 MkjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGn0[pJKSzVyPUCuNFAxOTV7IN88US=> MnrFV2FPT0WU
HCE-T M3vSbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTBwMECwNVYzKM7:TR?= MlzuV2FPT0WU
ESS-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMECwNVc6KM7:TR?= NHG0bpdUSU6JRWK=
D-566MG NV7QepZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnf2TWM2OD1yLkCwNFE5OiEQvF2= M3XCXXNCVkeHUh?=
CAL-62 NFXxT|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPmcIdCUUN3ME2wMlAxODF6NTFOwG0> MXTTRW5ITVJ?
GT3TKB MoTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nXfGlEPTB;MD6wNFAzOzJizszN NYjQNHc6W0GQR1XS
HSC-4 NFS5PZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;0TWM2OD1yLkCwNFI{QSEQvF2= NFLjXndUSU6JRWK=
KOSC-2 NYK2dld[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rMSWlEPTB;MD6wNFAzPTVizszN MlWzV2FPT0WU
NB14 M3W5[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIf3XIVKSzVyPUCuNFAxOjZizszN NYDJc4xNW0GQR1XS
ES8 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXDTWM2OD1yLkCwNFI3KM7:TR?= MWnTRW5ITVJ?
BFTC-905 NIi3[XNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPMTWM2OD1yLkCwNFI3QCEQvF2= NGflVZVUSU6JRWK=
A498 M3TsdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDvTWM2OD1yLkCwNFI4QCEQvF2= NVqxN4dPW0GQR1XS
HO-1-N-1 NIfCb|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTERWxRUUN3ME2wMlAxODJ6MTFOwG0> MoT5V2FPT0WU
SF539 NIXFPXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFH5PXNKSzVyPUCuNFAxOzB{IN88US=> M4[5WHNCVkeHUh?=
HuO-3N1 M{niWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4r2WGlEPTB;MD6wNFA{ODJizszN Mn3HV2FPT0WU
NCI-H510A NETDfWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvnU|BKSzVyPUCuNFAxOzN4IN88US=> M{PGcXNCVkeHUh?=
CAL-27 NEP2dWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfRcnc4UUN3ME2wMlAxODN|OTFOwG0> MYjTRW5ITVJ?
TE-8 NGfidY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvwR5p2UUN3ME2wMlAxODN4NjFOwG0> NHKwVYRUSU6JRWK=
VA-ES-BJ NYHiU2VQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEH2TW9KSzVyPUCuNFAxOzd3IN88US=> MoHSV2FPT0WU
RH-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwMECwN|g3KM7:TR?= MlnqV2FPT0WU
COLO-800 MluzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHaUnlKSzVyPUCuNFAxOzh6IN88US=> MUDTRW5ITVJ?
ES7 MmfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrFXnhKSzVyPUCuNFAxOzh7IN88US=> MYfTRW5ITVJ?
GAMG NHTXcYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmf6TWM2OD1yLkCwNFQyPiEQvF2= NVjhRpJQW0GQR1XS
Ca9-22 M3\Je2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwMECwOFI{KM7:TR?= MWnTRW5ITVJ?
SBC-1 Ml72S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojDTWM2OD1yLkCwNFQ{KM7:TR?= NGn4Wm1USU6JRWK=
RPMI-7951 NHrVUndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkC3TWM2OD1yLkCwNFQ1QCEQvF2= MnTBV2FPT0WU
SW1710 MkG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwMECwOFY3KM7:TR?= MWfTRW5ITVJ?
HGC-27 MoTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjUToJKSzVyPUCuNFAxPDdzIN88US=> MmXqV2FPT0WU
MC-IXC NILKR2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjP[3BKSzVyPUCuNFAxPDd7IN88US=> NXXVclc2W0GQR1XS
FTC-133 NYnzcnUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PJVGlEPTB;MD6wNFA1QDlizszN NGTMbmxUSU6JRWK=
HT-1080 MmO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDPW4dKSzVyPUCuNFAxPTBzIN88US=> M3KyfHNCVkeHUh?=
NMC-G1 MlraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjMUFZQUUN3ME2wMlAxODVzNzFOwG0> NGqzPJBUSU6JRWK=
GI-1 MmDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzHRVNKSzVyPUCuNFAxPTJ6IN88US=> MULTRW5ITVJ?
CGTH-W-1 M3i0Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVz2WppUUUN3ME2wMlAxODV2MjFOwG0> NX\yOlhZW0GQR1XS
A2058 M17tW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXnTWM2OD1yLkCwNFU1PCEQvF2= M4fHeHNCVkeHUh?=
ETK-1 NX;LfJZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrFUlVKSzVyPUCuNFAxPTV6IN88US=> MUXTRW5ITVJ?
NEC8 NF7lWZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzCTWM2OD1yLkCwNFU3OSEQvF2= NFnYRVhUSU6JRWK=
TE-11 NHTs[IlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PQ[mlEPTB;MD6wNFA2PjlizszN M{D2UHNCVkeHUh?=
NCI-H720 NFHCSVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMECwOVgh|ryP MlyzV2FPT0WU
PSN1 MmTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrGZ4NiUUN3ME2wMlAxODV6MTFOwG0> NF3OfplUSU6JRWK=
SW780 M2nzOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwMECwOVg4KM7:TR?= M2nvRXNCVkeHUh?=
8-MG-BA M3rrTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwMECwOVg6KM7:TR?= NVzmWoEyW0GQR1XS
EC-GI-10 Ml7KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjzU4lNUUN3ME2wMlAxODV7MjFOwG0> NHzLZlRUSU6JRWK=
SJSA-1 NYDzfmpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkO2TWM2OD1yLkCwNFYyPSEQvF2= NVP4dGRXW0GQR1XS
639-V M1vrN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3jRYk4UUN3ME2wMlAxODZ2NzFOwG0> NH21fHRUSU6JRWK=
PFSK-1 M{fTXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU[5OJU2UUN3ME2wMlAxODZ3NzFOwG0> M4e1RXNCVkeHUh?=
DMS-273 NVPLWmZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVSyS4R5UUN3ME2wMlAxODZ5NDFOwG0> NUHwXYdzW0GQR1XS
TE-9 M4THd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDnWYpUUUN3ME2wMlAxODZ5NjFOwG0> NFrlZY9USU6JRWK=
SCC-25 M1XR[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTBwMECwOlgh|ryP MVrTRW5ITVJ?
PA-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPybnZjUUN3ME2wMlAxODZ6NzFOwG0> MnPVV2FPT0WU
MHH-ES-1 NX;Ico1bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMECwO{DPxE1? M1H0UnNCVkeHUh?=
Daoy NV3lUoNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwMECwO{DPxE1? MmH6V2FPT0WU
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YKG-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDGTWM2OD1yLkCwNFcxPyEQvF2= M3zESXNCVkeHUh?=
Ca-Ski NWjUW|hHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoD6TWM2OD1yLkCwNFczQCEQvF2= NEXObHVUSU6JRWK=
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SCC-4 MkXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwMECwO|M6KM7:TR?= NF\NPXNUSU6JRWK=
EW-3 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwMECwO|Q2KM7:TR?= M{G1V3NCVkeHUh?=
P12-ICHIKAWA NUL0R2JTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DRe2lEPTB;MD6wNFA4PDVizszN M3faWHNCVkeHUh?=
HSC-2 M3nlb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zXS2lEPTB;MD6wNFA4PTVizszN MU\TRW5ITVJ?
HN NH\WeXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[2RZlKSzVyPUCuNFAxPzV6IN88US=> NYf0SnIyW0GQR1XS
LXF-289 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHibWVKSzVyPUCuNFAxPzV6IN88US=> M1uwVnNCVkeHUh?=
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KYSE-510 NYnvc3lmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XVPWlEPTB;MD6wNFA5PCEQvF2= MUfTRW5ITVJ?
8505C M{DyVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nMOmlEPTB;MD6wNFA5PTRizszN NGroVlZUSU6JRWK=
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NBsusSR NGqzbotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwMECxNUDPxE1? MYjTRW5ITVJ?
LNCaP-Clone-FGC MonSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwMECxNUDPxE1? NX;XeVlpW0GQR1XS
EPLC-272H MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTrWXFkUUN3ME2wMlAxOTFzIN88US=> MVLTRW5ITVJ?
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LOXIMVI MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2e5R2lEPTB;MD6wNFEyPiEQvF2= NF\nNIJUSU6JRWK=
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DB M{Hq[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHG3T4RKSzVyPUCuNFAyPzhizszN MVXTRW5ITVJ?
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OVCAR-5 Ml\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnT2TWM2OD1yLkCwNVk6KM7:TR?= MVHTRW5ITVJ?
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LCLC-103H M4S4PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwMECyPVMh|ryP M4Hp[HNCVkeHUh?=
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DU-4475 Mn7IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\CcWlEPTB;MD6wNFMxOiEQvF2= M4H5THNCVkeHUh?=
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LS-411N Mo\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfIXFhFUUN3ME2wMlAxOzF2IN88US=> M13aUnNCVkeHUh?=
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UACC-62 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMECzN{DPxE1? MXPTRW5ITVJ?
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CAL-120 NES3e2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwMEC0N|Uh|ryP MnXqV2FPT0WU
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OCUB-M NHT3bHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnH0TWM2OD1yLkCwOFM5KM7:TR?= NVXHdG5qW0GQR1XS
Calu-6 M1juemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwMEC0OFch|ryP M{LPSnNCVkeHUh?=
MDA-MB-453 NGDMelNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMEC0OVEh|ryP MUTTRW5ITVJ?
MKN45 NWnEb2VpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMEC0OVMh|ryP MYXTRW5ITVJ?
ECC10 NH3CSWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fKUWlEPTB;MD6wNFQ3KM7:TR?= NIL3[2xUSU6JRWK=
RVH-421 MlfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjmTWM2OD1yLkCwOFYyKM7:TR?= NWe4VJlMW0GQR1XS
TGBC11TKB M3zmXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoniTWM2OD1yLkCwOFY6KM7:TR?= NGLZSmNUSU6JRWK=
MOLT-4 NGXYSHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTRNGZKSzVyPUCuNFA1PzFizszN MlrRV2FPT0WU
LN-405 NEi4OWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTBwMEC0PFIh|ryP NWK5Z4xiW0GQR1XS
S-117 MnTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4X5U2lEPTB;MD6wNFQ5PiEQvF2= NUTabZN{W0GQR1XS
RPMI-8226 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XhW2lEPTB;MD6wNFQ6PyEQvF2= MXvTRW5ITVJ?
KYSE-150 Ml\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYmzbnQ2UUN3ME2wMlAxPDl7IN88US=> NVLhN|RFW0GQR1XS
NCI-H1666 MnrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPt[Jh2UUN3ME2wMlAxPTB3IN88US=> M3XMe3NCVkeHUh?=
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GB-1 NGP6bmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zuZ2lEPTB;MD6wNFUyOSEQvF2= MY\TRW5ITVJ?
KASUMI-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33rPGlEPTB;MD6wNFUyOSEQvF2= NHPOe5dUSU6JRWK=
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BV-173 NYnC[YJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\yeG5KSzVyPUCuNFA2OyEQvF2= MWnTRW5ITVJ?
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LB2241-RCC NVPINpU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fhUmlEPTB;MD6wNFU{OSEQvF2= M{XSbnNCVkeHUh?=
NCI-H2170 M1vWV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTFXXFKSzVyPUCuNFA2OzVizszN NUPZXWhJW0GQR1XS
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NCI-H1651 M4XoWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzzTWM2OD1yLkCwOVQh|ryP MYrTRW5ITVJ?
NCI-SNU-5 Mn7zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{G5RWlEPTB;MD6wNFU1PSEQvF2= MXvTRW5ITVJ?
SN12C M2X5eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnVcolKSzVyPUCuNFA2PSEQvF2= M4mxbHNCVkeHUh?=
KY821 NX7wfWtFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULwSlFNUUN3ME2wMlAxPTVzIN88US=> MkG0V2FPT0WU
SW1573 NYHvN|FST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMEC1OVQh|ryP M4TsOXNCVkeHUh?=
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MPP-89 NFzLUWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17Q[GlEPTB;MD6wNFU3PyEQvF2= M{HnNXNCVkeHUh?=
HuCCT1 MlzuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TCTGlEPTB;MD6wNFU3QCEQvF2= M4\XXnNCVkeHUh?=
SW1783 M1nlbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2D4UGlEPTB;MD6wNFU4KM7:TR?= NHLYTmpUSU6JRWK=
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OVCAR-4 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\5TWM2OD1yLkCwOVg3KM7:TR?= NV7MfFV[W0GQR1XS
MMAC-SF MljOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfyfZI6UUN3ME2wMlAxPTh4IN88US=> MXnTRW5ITVJ?
COLO-824 Mlu5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDKVYNIUUN3ME2wMlAxPTlizszN M165XHNCVkeHUh?=
HCC38 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMEC2JO69VQ>? MVrTRW5ITVJ?
NCI-H1648 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwMEC2NFEh|ryP M1\1U3NCVkeHUh?=
NCI-H1573 NHzRRoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUewbnVVUUN3ME2wMlAxPjB5IN88US=> NFjHXYNUSU6JRWK=
MFM-223 NHG4Xm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMEC2NVYh|ryP MULTRW5ITVJ?
NCI-H810 NWDwTHI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDIWnZrUUN3ME2wMlAxPjJ{IN88US=> NFjCOFFUSU6JRWK=
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NCI-H1755 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTye2xKSzVyPUCuNFA3OjRizszN MmTxV2FPT0WU
KYSE-70 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkixTWM2OD1yLkCwOlI1KM7:TR?= MYPTRW5ITVJ?
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WM-115 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1roR2lEPTB;MD6wNFYzPyEQvF2= MoHBV2FPT0WU
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MEL-JUSO MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwMEC2N|kh|ryP Mn7uV2FPT0WU
IGR-1 M{ftNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEW2RZlKSzVyPUCuNFA3PDFizszN MYHTRW5ITVJ?
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KARPAS-45 M4TkTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLnTWM2OD1yLkCwOlUzKM7:TR?= MYPTRW5ITVJ?
HC-1 MnnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMEC2OVYh|ryP MnfOV2FPT0WU
MZ2-MEL MkfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwMEC2OVgh|ryP MVnTRW5ITVJ?
NCI-H1355 NFmzbpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMEC2O|kh|ryP M2fqR3NCVkeHUh?=
HuP-T4 NY[wd4F1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrK[ndKSzVyPUCuNFA3PzlizszN MVzTRW5ITVJ?
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SCC-15 M37tXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUP5[4hWUUN3ME2wMlAxPjh7IN88US=> NWTOZlExW0GQR1XS
CP50-MEL-B MnS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwMEC2PVMh|ryP MUXTRW5ITVJ?
DMS-114 NYqwVIpJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\wTWM2OD1yLkCwOlk3KM7:TR?= MmHHV2FPT0WU
KYSE-520 NXS1SmpJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMEC3JO69VQ>? NEDROoNUSU6JRWK=
NCI-H2228 NGHQb2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{C2[mlEPTB;MD6wNFczPSEQvF2= M2fyVnNCVkeHUh?=
COLO-829 NH\pWnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXn4SWo3UUN3ME2wMlAxPzJ3IN88US=> MXnTRW5ITVJ?
NCI-H2052 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFr0XlhKSzVyPUCuNFA4OjdizszN M17I[HNCVkeHUh?=
HOP-92 Ml7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\HdGlEPTB;MD6wNFc{KM7:TR?= NXXzNZB5W0GQR1XS
MDA-MB-231 NVXxXlQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrlbXl4UUN3ME2wMlAxPzNizszN M2fKWnNCVkeHUh?=
SK-MEL-30 NIHqTnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XBOGlEPTB;MD6wNFc{OiEQvF2= MlW0V2FPT0WU
NCI-H2087 M1XUXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFX6c3hKSzVyPUCuNFA4PDhizszN Ml\LV2FPT0WU
SW900 Ml;2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPzbmVKSzVyPUCuNFA4PTVizszN NFz2Z2dUSU6JRWK=
NCI-H358 NH65fYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHT0R|VKSzVyPUCuNFA4PThizszN NVzEe2lqW0GQR1XS
NCI-H2126 MmXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zxd2lEPTB;MD6wNFc4OyEQvF2= NVrMcmZ{W0GQR1XS
TGBC24TKB MkTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonlTWM2OD1yLkCwO|gyKM7:TR?= NEOxR3NUSU6JRWK=
786-0 NXKyUmdlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVziTGRSUUN3ME2wMlAxPzh4IN88US=> MVTTRW5ITVJ?
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LU-65 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwMEO5NFQh|ryP MW\TRW5ITVJ?
NB6 NVzVfmRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonzTWM2OD1yLkCzPVUzKM7:TR?= M4LqRnNCVkeHUh?=
HT M3XwcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2facGlEPTB;MD6wOFAxPyEQvF2= NWX4eWdHW0GQR1XS
COLO-684 M2W2V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nrcWlEPTB;MD6wOFA6PSEQvF2= NYLWNYVOW0GQR1XS
NCI-H1693 Mn20S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwMESzNFUh|ryP NUjQOllTW0GQR1XS
LAN-6 NVfBSHUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLMTWM2OD1yLkC0N|M2KM7:TR?= NEnLXphUSU6JRWK=
MDA-MB-175-VII MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMES0NVch|ryP M17yV3NCVkeHUh?=
KMOE-2 NWq0XINMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwMES0Olkh|ryP MVfTRW5ITVJ?
DMS-79 MlfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rEcmlEPTB;MD6wOFU4QSEQvF2= MYjTRW5ITVJ?
MHH-NB-11 M1;TS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHSxfHhKSzVyPUCuNFQ3OTRizszN M1;YSnNCVkeHUh?=
NCI-H69 NHqxcnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\2bWlEPTB;MD6wOFg1QSEQvF2= M4m4TXNCVkeHUh?=
KE-37 NYPacGk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHpdohKSzVyPUCuNFUxOSEQvF2= MYrTRW5ITVJ?
Ramos-2G6-4C10 NWXU[JR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFf3[otKSzVyPUCuNFUxPjdizszN NX\LVZJnW0GQR1XS
NCI-H1793 M2HZXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\SWFNKSzVyPUCuNFUxQTNizszN MWHTRW5ITVJ?
HT-1376 MlXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmC2TWM2OD1yLkC1NVg3KM7:TR?= NHP3O3dUSU6JRWK=
EKVX MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nFN2lEPTB;MD6wOVM5PCEQvF2= MnXVV2FPT0WU
Capan-2 M1vtPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;5V5RKSzVyPUCuNFU{QTZizszN M2j4WXNCVkeHUh?=
DoTc2-4510 NH7CXmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\MSWlEPTB;MD6wOVQ1PiEQvF2= MmTDV2FPT0WU
UACC-893 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHITWM2OD1yLkC1OFYzKM7:TR?= M4fZfXNCVkeHUh?=
SK-MEL-3 NGLwdotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TjeGlEPTB;MD6wOVc5QCEQvF2= NHXndVNUSU6JRWK=
SK-MEL-1 Mmn0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DUfWlEPTB;MD6wOVgh|ryP MofJV2FPT0WU
SW948 NGX1d|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HzUWlEPTB;MD6wOVk6PiEQvF2= M{LGXHNCVkeHUh?=
P30-OHK NILRXlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LxTmlEPTB;MD6wOlE3PyEQvF2= MV3TRW5ITVJ?
NH-12 NVLCfXhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWr2dmI2UUN3ME2wMlA3OjR2IN88US=> MUjTRW5ITVJ?
KU-19-19 M{jONGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfUTWM2OD1yLkC2N|YyKM7:TR?= NXKwUGxQW0GQR1XS
A431 NITaOG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUS5fYtoUUN3ME2wMlA3Ozd2IN88US=> MY\TRW5ITVJ?
NCI-H2405 MmW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLXNndlUUN3ME2wMlA3Ozh|IN88US=> MYTTRW5ITVJ?
KARPAS-299 NUnVb2x4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHS2ZXNKSzVyPUCuNFY2QDJizszN NF7DVotUSU6JRWK=
BALL-1 MnTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7kUXlZUUN3ME2wMlA3Pjd2IN88US=> NVKwUFdZW0GQR1XS
KURAMOCHI M3X2WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnPd|Z1UUN3ME2wMlA4ODd|IN88US=> NVuzeoNKW0GQR1XS
LS-1034 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHldohKSzVyPUCuNFc{PjlizszN NV;CdWl6W0GQR1XS
MFE-280 Mmm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUe3T3ZKUUN3ME2wMlA4PTN4IN88US=> M17yUXNCVkeHUh?=
HOP-62 NHv1eZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMEe2O|Yh|ryP M4PmdXNCVkeHUh?=
KG-1 M2D0NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\sUmlEPTB;MD6wO|c5PyEQvF2= MWDTRW5ITVJ?
CW-2 M1H1XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4CzT2lEPTB;MD6wO|g{OiEQvF2= M1\rcHNCVkeHUh?=
SW837 M2PPPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLZWmlKSzVyPUCuNFg{PDJizszN NUfQS3FjW0GQR1XS
MFH-ino MmPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTGXnY3UUN3ME2wMlA5PTBzIN88US=> M1L0VnNCVkeHUh?=
HCC1419 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMEi5PFch|ryP NVPYWYd5W0GQR1XS
HMV-II NV7DeoUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zTOmlEPTB;MD6wPVAyKM7:TR?= NHjERVVUSU6JRWK=
BEN NVvUfYtCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXvTWM2OD1yLkC5N|g2KM7:TR?= MV\TRW5ITVJ?
SK-N-FI NX3XVI17T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rDWmlEPTB;MD6wPVU2PiEQvF2= NEHNOo9USU6JRWK=
JVM-2 M1;3XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moj6TWM2OD1yLkC5O|E3KM7:TR?= NU[ze5BCW0GQR1XS
CAL-54 NHvrOlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzNTWM2OD1yLkGwNFQh|ryP NFPZTGlUSU6JRWK=
T84 MlTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{[xWmlEPTB;MD6xNFk2OiEQvF2= M4HkcHNCVkeHUh?=
SHP-77 NWfEbpFXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTFTWM2OD1yLkGxOlQyKM7:TR?= M1\Md3NCVkeHUh?=
G-361 NY\kOpFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHJTWM2OD1yLkGyN|I1KM7:TR?= NXfafHUzW0GQR1XS
Calu-3 NX6yeWpUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwMUO4NVYh|ryP NGTXXFFUSU6JRWK=
HCC1937 NVTDUGdWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\ZcGlEPTB;MD6xOFk{PyEQvF2= MY\TRW5ITVJ?
KM-H2 MojUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3ntTmlEPTB;MD6xOVAyKM7:TR?= MnrjV2FPT0WU
769-P M3zkemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMUW4OFMh|ryP NXLseHpzW0GQR1XS
NCI-H1304 NFTGcWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2i0c2lEPTB;MD6xOlA3OSEQvF2= MWLTRW5ITVJ?
D-542MG MkHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;nTWM2OD1yLkG2Nlc5KM7:TR?= NYC3VoM4W0GQR1XS
ATN-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwMUe0OFEh|ryP MUnTRW5ITVJ?
NCI-H2029 NVP6[WpmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX31U5BEUUN3ME2wMlIxOjR|IN88US=> MoH6V2FPT0WU
ZR-75-30 M3SyPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvP[FZlUUN3ME2wMlIxPjR|IN88US=> MlHlV2FPT0WU
SW1116 NITDeHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMkGxNVch|ryP NX[1W3p3W0GQR1XS
CCRF-CEM MoXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XOWGlEPTB;MD6yO|YyPCEQvF2= NF7P[WFUSU6JRWK=
LU-135 NVTEfndHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjxTWM2OD1yLkK3O|M6KM7:TR?= MX3TRW5ITVJ?
MC116 NVjhdGVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTyUnRKSzVyPUCuNlg{ODlizszN NGL6TVBUSU6JRWK=
LS-513 MnrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwMki3O|Mh|ryP NIfMWlNUSU6JRWK=
NCI-H630 NGW1bG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMkmzO|Yh|ryP MlrkV2FPT0WU
L-428 M4n4OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGK2ZlBKSzVyPUCuNlk5QDNizszN MYLTRW5ITVJ?
UM-UC-3 M2PuSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwM{GyPVEh|ryP NFSyS4hUSU6JRWK=
NCI-H1838 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDsdHk3UUN3ME2wMlMyPzh2IN88US=> MYjTRW5ITVJ?
HEL NWHVNmM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnX4TWM2OD1yLkOyNlQh|ryP M1rZcXNCVkeHUh?=
OCI-AML2 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3WXohtUUN3ME2wMlMzOjl6IN88US=> NGXnRnlUSU6JRWK=
A3-KAW M2XxW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn61TWM2OD1yLkOzOFc4KM7:TR?= NXPOSIo6W0GQR1XS
IGROV-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjHNIpKSzVyPUCuN|M4PTVizszN Mkn1V2FPT0WU
Mo-T NFvpOodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwM{O4OVMh|ryP MkWxV2FPT0WU
HDLM-2 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHqUGZzUUN3ME2wMlM{QSEQvF2= NHnYRVJUSU6JRWK=
HCC1569 M4LaUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXrW4NKSzVyPUCuN|Q{ODlizszN MWLTRW5ITVJ?
COLO-678 MmKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrvUVNzUUN3ME2wMlM4ODB{IN88US=> M3\1WHNCVkeHUh?=
COR-L105 NYPwbphzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\FTWM2OD1yLkO3PVMh|ryP M{\HOXNCVkeHUh?=
SK-MEL-24 M3jXNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwM{izPFIh|ryP NWPJOm46W0GQR1XS
COLO-320-HSR MmrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwNEO5O|Yh|ryP NVn4VnF{W0GQR1XS
C8166 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;kc|VRUUN3ME2wMlQ6ODJ|IN88US=> NVHveY17W0GQR1XS
COLO-679 MmXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwNkKxO|Ih|ryP M2PkXnNCVkeHUh?=
TE-12 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jXbmlEPTB;MD62OVM6PCEQvF2= M1n5PXNCVkeHUh?=
HAL-01 MoHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWntc|lKUUN3ME2wMlY3OjJizszN M1rzWXNCVkeHUh?=
H-EMC-SS M3THXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PyTmlEPTB;MD63NFU1PiEQvF2= NGnO[5ZUSU6JRWK=
SNU-449 NEiwRo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfYfHJKSzVyPUCuO|I4PDhizszN NX33UpFRW0GQR1XS
C32 M1zBTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwN{SxNVIh|ryP NV\EUW9RW0GQR1XS
K-562 NETwb5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwN{ewNlQh|ryP NILCXY9USU6JRWK=
DJM-1 NVXid2o3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1f0cWlEPTB;MD63PFc5OSEQvF2= MWXTRW5ITVJ?
RCC10RGB MoPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwN{mxPFMh|ryP MoTjV2FPT0WU
CAL-85-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVS0emM2UUN3ME2wMlkxPyEQvF2= MmC5V2FPT0WU
NY M1[ze2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPLTWM2OD1yLkmzN|UzKM7:TR?= MWPTRW5ITVJ?
NCI-H1993 M1S0V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTFwMUmyPFkh|ryP NGm1OmRUSU6JRWK=
SK-OV-3 NWHYOoJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrwOmJKSzVyPUGuNlIxQDlizszN NFfFUFlUSU6JRWK=

多くの細胞株試験データを見る場合、クリックしてください

体内試験 Docetaxel (33 mg/kg/dose, given i.v. every 4 days for 3 injections) results in a tumor growth delay of 19.3 days in M2OL2 colon xenografts. Docetaxel also shows great antitumor activities in MX-1, SK-MEL-2, LX-1 and OVCAR-3 xenografts. Docetaxel inhibits the angiogenic response to fibroblast growth factor 2 with IC 50 of 5.4 mg/kg when injected twice weekly over a 14-day period, and angiogenesis is completely blocked in mice that receives 10 mg/kg Docetaxel. Docetaxel has selectivity for endothelial cell migration and/or microvessel formation because infiltration of inflammatory cells into the Matrigel plug is much less sensitive to inhibition by Docetaxel. [7]

お薦めの試験操作(参考用のみ)

細胞試験: [5]
+ 展開
  • 細胞株: Human gastric cancer cell lines MKN-28
  • 濃度: 6 nM
  • 反応時間: 3 days
  • 実験の流れ: 2000 cells in 180 μL of medium are seeded in a 96-well plate, and 20 μL of drug solution is simultaneously added in triplicate to each well. The plate is incubated for 3 days at 37°C in a humidified atmosphere of 5% CO2. On day 3, 25 μL of MTT reagent is added to each well. After 4 h of incubation, the medium is removed by aspiration. 0.2 mL of dimethylsulphoxide (DMSO) is added to each well and thoroughly mixed by using a mechanical plate mixer to dissolve the resulting MTT-formazan crystals. Absorbance at 540 nm (OD) is measured by a reader.
    (参考用のみ)
動物試験:[6]
+ 展開
  • 動物モデル: Human colon carcinomas xenografts CX-1
  • 製剤: 50 mg/mL stock solution in ethanol by adding an equal volume of polysorbate 80 and diluting with 5% dextrose in water to the final volume
  • 投薬量: 33 mg/kg
  • 投与方法: i.v. every 4 days for 3 injections
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 100 mg/mL (123.78 mM)
Ethanol 53 mg/mL warmed (65.6 mM)
Water Insoluble
体内 順序で溶剤を入れること:
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
2mg/mL

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 807.88
化学式

C43H53NO14

CAS No. 114977-28-5
保管
別名 RP56976, NSC 628503

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02124902 Recruiting Triple Negative Breast Neoplasms Washington University School of Medicine July 7, 2014 Phase 2
NCT01683994 Recruiting Prostatic Neoplasms National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) September 6, 2012 Phase 1|Phase 2
NCT02649855 Recruiting Prostate Cancer|Prostate Neoplasms|Neoplasms, Prostatic National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) January 4, 2016 Phase 2
NCT03041181 Recruiting Non-Squamous Non-Small Cell Lung Cancer (NSCLC)|Adenocarcinoma of the Lung|Lung Cancer Nasser Hanna, M.D.|Hoosier Cancer Research Network|Bristol-Myers Squibb January 27, 2017 Phase 2
NCT00251433 Active, not recruiting Neoplasms, Breast Novartis Pharmaceuticals|Novartis September 26, 2005 Phase 1
NCT01907529 Not yet recruiting Stage III Breast Cancer Hebei Medical University Fourth Hospital August 2018 Phase 2|Phase 3

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

Microtubule Associated信号経路図

相関Microtubule Associated製品

Tags: Docetaxelを買う | Docetaxel ic50 | Docetaxel供給者 | Docetaxelを購入する | Docetaxel費用 | Docetaxel生産者 | オーダーDocetaxel | Docetaxel化学構造 | Docetaxel分子量 | Docetaxel代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID