P450 (e.g. CYP17)

信号経路図

研究分野

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1123 Abiraterone 0.02 mg/mL 0.1 mg/mL 0.2 mg/mL
S1185 Ritonavir <1 mg/mL 100 mg/mL 3 mg/mL
S2246 Abiraterone Acetate <1 mg/mL <1 mg/mL 28 mg/mL
S1257 Posaconazole <1 mg/mL 100 mg/mL <1 mg/mL
S1442 Voriconazole <1 mg/mL 70 mg/mL 20 mg/mL
S4741 Danshensu 23 mg/mL <1 mg/mL <1 mg/mL
S1712 Deferasirox <1 mg/mL 74 mg/mL 2 mg/mL
S2187 Avasimibe <1 mg/mL 100 mg/mL 8 mg/mL
S1353 Ketoconazole <1 mg/mL 5 mg/mL 7 mg/mL
S2476 Itraconazole <1 mg/mL 7 mg/mL <1 mg/mL
S1331 Fluconazole <1 mg/mL 61 mg/mL 61 mg/mL
S1195 TAK-700 (Orteronel) <1 mg/mL 61 mg/mL 8 mg/mL
S2803 Galeterone <1 mg/mL 24 mg/mL 40 mg/mL
S2555 Clarithromycin <1 mg/mL 25 mg/mL <1 mg/mL
S2900 Cobicistat (GS-9350) <1 mg/mL 100 mg/mL 100 mg/mL
S2496 Ozagrel <1 mg/mL 46 mg/mL <1 mg/mL
S1739 Thiabendazole <1 mg/mL 40 mg/mL 1 mg/mL
S2046 Pioglitazone HCl <1 mg/mL 79 mg/mL 4 mg/mL
S2067 Ozagrel HCl 52 mg/mL 52 mg/mL 6 mg/mL
S1952 Methoxsalen <1 mg/mL 43 mg/mL 5 mg/mL
S2526 Alizarin <1 mg/mL 48 mg/mL <1 mg/mL
S4155 Chlorzoxazone <1 mg/mL 34 mg/mL 34 mg/mL
S2921 PF-4981517 <1 mg/mL 91 mg/mL <1 mg/mL
S2380 Diosmetin <1 mg/mL 60 mg/mL <1 mg/mL
S2262 Apigenin <1 mg/mL 54 mg/mL <1 mg/mL
S2268 Baicalein <1 mg/mL 54 mg/mL <1 mg/mL
S2394 Naringenin <1 mg/mL 54 mg/mL 5 mg/mL
S2401 Sodium Danshensu 2 mg/mL 7 mg/mL <1 mg/mL
S2329 Naringin <1 mg/mL 100 mg/mL 2 mg/mL
S4221 Benzbromarone <1 mg/mL 85 mg/mL 9 mg/mL
S2344 Piperine <1 mg/mL 57 mg/mL 57 mg/mL

亜型選択性的な製品

製品コード 製品説明 文献中の引用 お客様のフィードバック
S1123

Abiraterone

Abirateroneは、2nMのIC50による強力なCYP17阻害剤です。

S1185

Ritonavir

Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS.

S2246

Abiraterone Acetate

Abiraterone Acetate は、72nMのIC50によるステロイドのシトクロムP450 17alpha-ヒドロキシラーゼ-17,20-リアーゼ(CYP17)阻害剤であるAbirateroneのアセテート塩の形です。

S1257

Posaconazole

Posaconazole (Noxafil)は、ステロールC14ɑ非メチラーゼ阻害剤で、IC50 が 0.25 nMです。

S1442

Voriconazole

Voriconazole is a triazole antifungal medication that is generally used to treat serious, invasive fungal infections.

S2187

Avasimibe

Avasimibe は、ACATとP450イソ酵素CYP2C9を妨げます。IC50 がそれぞれ 3.3 μM と 2.9 μMです。

S1353

Ketoconazole

Ketoconazole(合成イミダゾール抗真菌物質)は、表在性真菌感染のために効果的です。

S2476

Itraconazole

Itraconazole is a triazole antifungal agent.

S1331

Fluconazole

Fluconazole is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.

S1195

TAK-700 (Orteronel)

TAK-700(Orteronel)は、有力で非常に選択的なネズミと人間の17,20-リアーゼ阻害剤で、IC50 がそれぞれ 54 nM と 38 nMです。

S2803

Galeterone

Galeteroneは、選択的なCYP17阻害剤とアンドロゲン受容体(AR)敵対者で、IC50 がそれぞれ 300 nM と 384 nMです。

S2555

Clarithromycin

Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor.

S2900

Cobicistat (GS-9350)

Cobicistat(GS-9350)は、CYP3Aの強力で選択的な阻害剤で、IC50 が30-285 nMです。

S2496

Ozagrel

Ozagrel is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia.

S1739

Thiabendazole

Thiabendazole inhibites the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property.

S2046

Pioglitazone HCl

Pioglitazone HCl is a selective peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist, used to treat diabetes.

S2067

Ozagrel HCl

Ozagrel HCl is a selective thromboxane A2 synthetase enzyme inhibitors with IC50 of 11 nM, used as antiasthmatic agent.

S1952

Methoxsalen

Methoxsalen (Oxsoralen) a naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia, is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the ski異໔畱✑畯腱

S2526

Alizarin

リザリンは、P450アイソフォームCYP1A1、CYP1A2とCYP1B1を強く妨げまして、 IC50 がそれぞれ 6.2 μM、 10.0 μM、2.7 μMです。

S2921

PF-4981517

PF-4981517は、CYP3A4の強力で選択的な阻害剤で、IC50 が 0.03 µMです。

S2380

Diosmetin

Diosmetin is a bioflavonoid found in spearmint, oregano, and many other plants.

S2262

Apigenin

Apigenin is a potent CYP2C9 inhibitor with an IC50 of 23 pM.

S2268

Baicalein

Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.

S2394

Naringenin

Naringenin is a flavonoid that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.

S2401

Sodium Danshensu

Sodium Danshensu is a mono sodium of danshensu which is a compound isolated from Salvia miltiorrhiza Bge.

S2329

Naringin

Naringin is a flavanone glycoside and is a major flavonoid in grapefruit and gives the grapefruit juice its bitter taste.

S4221

Benzbromarone

Benzbromarone is a CYP2C9 inhibitor, it binds to CYP2C9 with Ki value of 19.3 nM.

S2344

Piperine

Piperine is the alkaloid responsible for the pungency of black pepper and long pepper, along with chavicine (an isomer of piperine). It has also been used in some forms of traditional medicine and as an insecticide.

S4741

Danshensu

S1712

Deferasirox

Deferasirox(Exjade) is a rationally-designed oral iron chelator.

S4155

Chlorzoxazone

Chlorzoxazoneはヒト肝チトクロームP-450IIE1ための筋弛緩薬、およびプローブです。

製品コード 製品説明 文献中の引用 お客様のフィードバック
S1123

Abiraterone

Abirateroneは、2nMのIC50による強力なCYP17阻害剤です。

S1185

Ritonavir

Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS.

S2246

Abiraterone Acetate

Abiraterone Acetate は、72nMのIC50によるステロイドのシトクロムP450 17alpha-ヒドロキシラーゼ-17,20-リアーゼ(CYP17)阻害剤であるAbirateroneのアセテート塩の形です。

S1257

Posaconazole

Posaconazole (Noxafil)は、ステロールC14ɑ非メチラーゼ阻害剤で、IC50 が 0.25 nMです。

S1442

Voriconazole

Voriconazole is a triazole antifungal medication that is generally used to treat serious, invasive fungal infections.

S2187

Avasimibe

Avasimibe は、ACATとP450イソ酵素CYP2C9を妨げます。IC50 がそれぞれ 3.3 μM と 2.9 μMです。

S1353

Ketoconazole

Ketoconazole(合成イミダゾール抗真菌物質)は、表在性真菌感染のために効果的です。

S2476

Itraconazole

Itraconazole is a triazole antifungal agent.

S1331

Fluconazole

Fluconazole is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.

S1195

TAK-700 (Orteronel)

TAK-700(Orteronel)は、有力で非常に選択的なネズミと人間の17,20-リアーゼ阻害剤で、IC50 がそれぞれ 54 nM と 38 nMです。

S2803

Galeterone

Galeteroneは、選択的なCYP17阻害剤とアンドロゲン受容体(AR)敵対者で、IC50 がそれぞれ 300 nM と 384 nMです。

S2555

Clarithromycin

Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor.

S2900

Cobicistat (GS-9350)

Cobicistat(GS-9350)は、CYP3Aの強力で選択的な阻害剤で、IC50 が30-285 nMです。

S2496

Ozagrel

Ozagrel is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia.

S1739

Thiabendazole

Thiabendazole inhibites the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property.

S2046

Pioglitazone HCl

Pioglitazone HCl is a selective peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist, used to treat diabetes.

S2067

Ozagrel HCl

Ozagrel HCl is a selective thromboxane A2 synthetase enzyme inhibitors with IC50 of 11 nM, used as antiasthmatic agent.

S1952

Methoxsalen

Methoxsalen (Oxsoralen) a naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia, is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the ski異໔畱✑畯腱

S2526

Alizarin

リザリンは、P450アイソフォームCYP1A1、CYP1A2とCYP1B1を強く妨げまして、 IC50 がそれぞれ 6.2 μM、 10.0 μM、2.7 μMです。

S2921

PF-4981517

PF-4981517は、CYP3A4の強力で選択的な阻害剤で、IC50 が 0.03 µMです。

S2380

Diosmetin

Diosmetin is a bioflavonoid found in spearmint, oregano, and many other plants.

S2262

Apigenin

Apigenin is a potent CYP2C9 inhibitor with an IC50 of 23 pM.

S2268

Baicalein

Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.

S2394

Naringenin

Naringenin is a flavonoid that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.

S2401

Sodium Danshensu

Sodium Danshensu is a mono sodium of danshensu which is a compound isolated from Salvia miltiorrhiza Bge.

S2329

Naringin

Naringin is a flavanone glycoside and is a major flavonoid in grapefruit and gives the grapefruit juice its bitter taste.

S4221

Benzbromarone

Benzbromarone is a CYP2C9 inhibitor, it binds to CYP2C9 with Ki value of 19.3 nM.

S2344

Piperine

Piperine is the alkaloid responsible for the pungency of black pepper and long pepper, along with chavicine (an isomer of piperine). It has also been used in some forms of traditional medicine and as an insecticide.

製品コード 製品説明 文献中の引用 お客様のフィードバック
S4741

Danshensu

S1712

Deferasirox

Deferasirox(Exjade) is a rationally-designed oral iron chelator.

2014, 509(7498):105-9

S4155

Chlorzoxazone

Chlorzoxazoneはヒト肝チトクロームP-450IIE1ための筋弛緩薬、およびプローブです。