COX

信号経路図

研究分野

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1261 Celecoxib <1 mg/mL 76 mg/mL 33 mg/mL
S1255 Nepafenac <1 mg/mL 50 mg/mL <1 mg/mL
S1638 Ibuprofen <1 mg/mL 41 mg/mL 41 mg/mL
S1723 Indomethacin <1 mg/mL 72 mg/mL 24 mg/mL
S2007 Sulindac <1 mg/mL 71 mg/mL 9 mg/mL
S8433 NS-398 (NS398) <1 mg/mL 62 mg/mL <1 mg/mL
S3043 Rofecoxib <1 mg/mL 63 mg/mL <1 mg/mL
S1734 Meloxicam <1 mg/mL 30 mg/mL <1 mg/mL
S4028 Dexamethasone Sodium Phosphate 103 mg/mL <1 mg/mL <1 mg/mL
S3023 Bufexamac <1 mg/mL 45 mg/mL 3 mg/mL
S3017 Aspirin <1 mg/mL 36 mg/mL 36 mg/mL
S1761 Suprofen <1 mg/mL 52 mg/mL 52 mg/mL
S1713 Piroxicam <1 mg/mL 66 mg/mL 1 mg/mL
S1328 Etodolac <1 mg/mL 58 mg/mL 58 mg/mL
S1645 Ketoprofen <1 mg/mL 51 mg/mL 51 mg/mL
S1903 Diclofenac Sodium 14 mg/mL 64 mg/mL 64 mg/mL
S1518 Ibuprofen Lysine 71 mg/mL <1 mg/mL <1 mg/mL
S2047 Lornoxicam <1 mg/mL 3 mg/mL <1 mg/mL
S1646 Ketorolac <1 mg/mL 75 mg/mL 75 mg/mL
S1626 Naproxen Sodium 50 mg/mL 3 mg/mL <1 mg/mL
S2903 Lumiracoxib <1 mg/mL 59 mg/mL <1 mg/mL
S2531 Asaraldehyde <1 mg/mL 39 mg/mL 16 mg/mL
S1960 Pranoprofen <1 mg/mL 51 mg/mL 6 mg/mL
S3008 Zaltoprofen <1 mg/mL 60 mg/mL 31 mg/mL
S2602 Acemetacin <1 mg/mL 83 mg/mL 58 mg/mL
S1959 Tolfenamic Acid <1 mg/mL 52 mg/mL <1 mg/mL
S4049 Valdecoxib <1 mg/mL 63 mg/mL 18 mg/mL
S2577 Phenacetin <1 mg/mL 36 mg/mL 36 mg/mL
S2040 Nimesulide <1 mg/mL 62 mg/mL <1 mg/mL
S4149 Amfenac Sodium Monohydrate 59 mg/mL 59 mg/mL 4 mg/mL
S4248 Bromfenac Sodium 71 mg/mL 71 mg/mL 2 mg/mL
S4051 Nabumetone <1 mg/mL 46 mg/mL 25 mg/mL
S3018 Niflumic acid <1 mg/mL 56 mg/mL <1 mg/mL
S3173 Antipyrine 38 mg/mL 38 mg/mL 38 mg/mL
S4011 Ampiroxicam <1 mg/mL 90 mg/mL <1 mg/mL
S4032 Bismuth Subsalicylate <1 mg/mL 0.04 mg/mL <1 mg/mL
S4628 (+/-)-Sulfinpyrazone <1 mg/mL 80 mg/mL 64 mg/mL
S4136 Carprofen <1 mg/mL 55 mg/mL 55 mg/mL
S3063 Diclofenac Diethylamine <1 mg/mL 74 mg/mL 74 mg/mL
S4656 Parecoxib <1 mg/mL 74 mg/mL 2 mg/mL
S4609 Diflunisal <1 mg/mL 50 mg/mL 20 mg/mL
S4176 Trometamol 24 mg/mL 2 mg/mL <1 mg/mL
S4078 Mefenamic Acid <1 mg/mL 48 mg/mL <1 mg/mL
S4651 Etoricoxib <1 mg/mL 71 mg/mL 46 mg/mL
S4230 Oxaprozin <1 mg/mL 59 mg/mL 27 mg/mL
S2349 Rutaecarpine <1 mg/mL 24 mg/mL <1 mg/mL
S2351 Salicin 24 mg/mL 57 mg/mL <1 mg/mL
S4526 Fenbufen <1 mg/mL 50 mg/mL 50 mg/mL
S4539 Salicylic acid <1 mg/mL 27 mg/mL 27 mg/mL
S7889 Xanthohumol <1 mg/mL 70 mg/mL 70 mg/mL
S2108 Flunixin Meglumin 98 mg/mL 98 mg/mL 8 mg/mL
S4295 Meclofenamate Sodium 63 mg/mL 63 mg/mL 63 mg/mL

亜型選択性的な製品

製品コード 製品説明 文献中の使用例 お客様のフィードバック
S1261

Celecoxib

セレコキシブは、40nMのIC50による選択的なCOX-2阻害剤です。

S1255

Nepafenac

Nepafenac is a non-steroidal anti-inflammatory agent.

S1638

Ibuprofen

Ibuprofen は非ステロイド薬(NSAID)、COX-1とCOX-2 を抑制すると、IC50 がそれぞれ13 μM 、370 μMになる.

S1723

Indomethacin

Indomethacin(Indocid, Indocin) is a non-steroidal anti-inflammatory compound commonly used to reduce fever, pain, stiffness, and swelling.

S2007

Sulindac

Sulindac (Clinoril) is a non-steroidal anti-inflammatory agent of the arylalkanoic acid class.

S8433

NS-398 (NS398)

S3043

Rofecoxib

Rofecoxib is a COX-2 inhibitor with IC50 of 18 nM.

S1734

Meloxicam

Meloxicam (Mobic) is a nonsteroidal anti-inflammatory agent with analgesic and fever reducer effects.

S4028

Dexamethasone Sodium Phosphate

Dexamethasone Sodium Phosphateは一種の有効なステロイド薬(steroid drugs)の糖質コルチコイド類の合成物(synthetic member)で、一種の抗炎と免疫抑制効果をしているインターロイキン受容体調節剤です。

S3023

Bufexamac

ブフェキサマックは、8.9μMのEC50によるIFN-αの分泌のための酵素シクロオキシゲナーゼとHDAC6/HDAC10阻害剤です。

S3017

Aspirin

Aspirin is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.

S1761

Suprofen

Suprofen(Profenal) is an NSAID.

S1713

Piroxicam

Piroxicam is a non-selective COX inhibitor with an IC50 of 6 mM.

S1328

Etodolac

Etodolac is a COX inhibitor with an IC50 of 53.5 nM.

S1645

Ketoprofen

Ketoprofen is a non-selective NSAID with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively.

S1903

Diclofenac Sodium

Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.

S1518

Ibuprofen Lysine

Ibuprofen Lysine is a non-steroidal anti-inflammatory drug.

S2047

Lornoxicam

Lornoxicam is a COX-1 and COX-2 inhibitor with IC50 of 5 nM and 8 nM, respectively.

S1646

Ketorolac

Ketorolacは非選択COX阻害剤、人間COX-1とCOX-2に作用する時、IC50がそれぞれ1.23 µM と3.50 µM になる。

S1626

Naproxen Sodium

Naproxen Sodiumは非選択エポキシ合酵素阻害剤(COX)、COX-1とCOX-2に作用する時、IC50がそれぞれ2.2μg / mLと1.3μg / mLになる。

S2903

Lumiracoxib

Lumiracoxib is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4.

S2531

Asaraldehyde

Asaraldehyde is a selective COX-2 inhibitor.

S1960

Pranoprofen

Pranoprofen is a PGE2 inhibitor with IC50 of 7.5 μM.

S3008

Zaltoprofen

Zaltoprofen is an inhibitor of Cox-1 and Cox-2 for treatment of arthritis.

S2602

Acemetacin

Acemetacin is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.

S1959

Tolfenamic Acid

Tolfenamic acid is a COX-2 inhibitor with IC50 of 0.2 μM.

S4049

Valdecoxib

Valdecoxibは、COX-2の強力で選択的な阻害体で、IC50が5 nMです。

S2577

Phenacetin

Phenacetin is a non-opioid analgesic without anti-inflammatory properties.

S2040

Nimesulide

Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM.

S4149

Amfenac Sodium Monohydrate

Amfenac Sodium monohydrate、酢酸部分を有する非ステロイド系鎮痛薬、抗炎症薬です。

S4248

Bromfenac Sodium

Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) that has anti-inflammatory activity which may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.

S4051

Nabumetone

Nabumetone is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.

S3018

Niflumic acid

Niflumic acid is an inhibitor of cyclooxygenase-2 used for joint and muscular pain.

S3173

Antipyrine

Antipyrine is an analgesic and antipyretic agent.

S4011

Ampiroxicam

Ampiroxicamは、選択的でないシクロオキシゲナーゼ 抗炎症剤としての阻害剤です。

S4032

Bismuth Subsalicylate

Bismuth Subsalicylateはペプトビスモルの活性成分で、プロスタグランジンG/Hシンターゼ1/2を妨げます。

S4628

(+/-)-Sulfinpyrazone

S4136

Carprofen

CarprofenはイヌCOX2を阻害、IC50 が 0.03 mMです。

S3063

Diclofenac Diethylamine

Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

S4656

Parecoxib

S4609

Diflunisal

S4176

Trometamol

Trometamolは学界を治療するために使用されるプロトン受容体です。

S4078

Mefenamic Acid

Mefenamic acidは、COX-1COX-2の競争的阻害体です。

S4651

Etoricoxib

S4686

Vitamin E

Vitamin Eは一種の脂溶性のビタミンで、有効な抗酸化特性をしているんです。Vitamin Eは有効なペルオキシラジカルクリーナ(peroxyl radical scavenger)です。多数の組織に、Vitamin Eはシクロオキシゲナーゼを非競争的に抑制します。同時に、Vitamin EはVEGF遺伝子転写を抑制することを通じて、血管生成と腫瘍休眠を抑制します。

S4230

Oxaprozin

Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID) used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.

S2349

Rutaecarpine

Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs.

S2351

Salicin

Salicin is an alcoholic β-glycoside that contains D-glucose. Salicin is an anti-inflammatory agent that is produced from willow bark.

S4526

Fenbufen

S4539

Salicylic acid

S7889

Xanthohumol

Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Phase 1.

S2108

Flunixin Meglumin

Flunixin Meglumin is a potent inhibitor of the enzyme cyclooxygenase used as analgesic agent with anti-inflammatory and antipyretic activity.

S4295

Meclofenamate Sodium

Meclofenamate Sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea.

製品コード 製品説明 文献中の使用例 お客様のフィードバック
S1261

Celecoxib

セレコキシブは、40nMのIC50による選択的なCOX-2阻害剤です。

S1255

Nepafenac

Nepafenac is a non-steroidal anti-inflammatory agent.

S1638

Ibuprofen

Ibuprofen は非ステロイド薬(NSAID)、COX-1とCOX-2 を抑制すると、IC50 がそれぞれ13 μM 、370 μMになる.

S1723

Indomethacin

Indomethacin(Indocid, Indocin) is a non-steroidal anti-inflammatory compound commonly used to reduce fever, pain, stiffness, and swelling.

S2007

Sulindac

Sulindac (Clinoril) is a non-steroidal anti-inflammatory agent of the arylalkanoic acid class.

S8433

NS-398 (NS398)

S3043

Rofecoxib

Rofecoxib is a COX-2 inhibitor with IC50 of 18 nM.

S1734

Meloxicam

Meloxicam (Mobic) is a nonsteroidal anti-inflammatory agent with analgesic and fever reducer effects.

S4028

Dexamethasone Sodium Phosphate

Dexamethasone Sodium Phosphateは一種の有効なステロイド薬(steroid drugs)の糖質コルチコイド類の合成物(synthetic member)で、一種の抗炎と免疫抑制効果をしているインターロイキン受容体調節剤です。

S3023

Bufexamac

ブフェキサマックは、8.9μMのEC50によるIFN-αの分泌のための酵素シクロオキシゲナーゼとHDAC6/HDAC10阻害剤です。

S3017

Aspirin

Aspirin is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.

S1761

Suprofen

Suprofen(Profenal) is an NSAID.

S1713

Piroxicam

Piroxicam is a non-selective COX inhibitor with an IC50 of 6 mM.

S1328

Etodolac

Etodolac is a COX inhibitor with an IC50 of 53.5 nM.

S1645

Ketoprofen

Ketoprofen is a non-selective NSAID with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively.

S1903

Diclofenac Sodium

Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.

S1518

Ibuprofen Lysine

Ibuprofen Lysine is a non-steroidal anti-inflammatory drug.

S2047

Lornoxicam

Lornoxicam is a COX-1 and COX-2 inhibitor with IC50 of 5 nM and 8 nM, respectively.

S1646

Ketorolac

Ketorolacは非選択COX阻害剤、人間COX-1とCOX-2に作用する時、IC50がそれぞれ1.23 µM と3.50 µM になる。

S1626

Naproxen Sodium

Naproxen Sodiumは非選択エポキシ合酵素阻害剤(COX)、COX-1とCOX-2に作用する時、IC50がそれぞれ2.2μg / mLと1.3μg / mLになる。

S2903

Lumiracoxib

Lumiracoxib is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4.

S2531

Asaraldehyde

Asaraldehyde is a selective COX-2 inhibitor.

S1960

Pranoprofen

Pranoprofen is a PGE2 inhibitor with IC50 of 7.5 μM.

S3008

Zaltoprofen

Zaltoprofen is an inhibitor of Cox-1 and Cox-2 for treatment of arthritis.

S2602

Acemetacin

Acemetacin is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.

S1959

Tolfenamic Acid

Tolfenamic acid is a COX-2 inhibitor with IC50 of 0.2 μM.

S4049

Valdecoxib

Valdecoxibは、COX-2の強力で選択的な阻害体で、IC50が5 nMです。

S2577

Phenacetin

Phenacetin is a non-opioid analgesic without anti-inflammatory properties.

S2040

Nimesulide

Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM.

S4149

Amfenac Sodium Monohydrate

Amfenac Sodium monohydrate、酢酸部分を有する非ステロイド系鎮痛薬、抗炎症薬です。

S4248

Bromfenac Sodium

Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) that has anti-inflammatory activity which may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.

S4051

Nabumetone

Nabumetone is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.

S3018

Niflumic acid

Niflumic acid is an inhibitor of cyclooxygenase-2 used for joint and muscular pain.

S3173

Antipyrine

Antipyrine is an analgesic and antipyretic agent.

S4011

Ampiroxicam

Ampiroxicamは、選択的でないシクロオキシゲナーゼ 抗炎症剤としての阻害剤です。

S4032

Bismuth Subsalicylate

Bismuth Subsalicylateはペプトビスモルの活性成分で、プロスタグランジンG/Hシンターゼ1/2を妨げます。

S4628

(+/-)-Sulfinpyrazone

S4136

Carprofen

CarprofenはイヌCOX2を阻害、IC50 が 0.03 mMです。

S3063

Diclofenac Diethylamine

Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

S4656

Parecoxib

S4609

Diflunisal

S4176

Trometamol

Trometamolは学界を治療するために使用されるプロトン受容体です。

S4078

Mefenamic Acid

Mefenamic acidは、COX-1COX-2の競争的阻害体です。

S4651

Etoricoxib

S4686

Vitamin E

Vitamin Eは一種の脂溶性のビタミンで、有効な抗酸化特性をしているんです。Vitamin Eは有効なペルオキシラジカルクリーナ(peroxyl radical scavenger)です。多数の組織に、Vitamin Eはシクロオキシゲナーゼを非競争的に抑制します。同時に、Vitamin EはVEGF遺伝子転写を抑制することを通じて、血管生成と腫瘍休眠を抑制します。

S4230

Oxaprozin

Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID) used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.

S2349

Rutaecarpine

Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs.

S2351

Salicin

Salicin is an alcoholic β-glycoside that contains D-glucose. Salicin is an anti-inflammatory agent that is produced from willow bark.

S4526

Fenbufen

S4539

Salicylic acid

S7889

Xanthohumol

Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Phase 1.

S2108

Flunixin Meglumin

Flunixin Meglumin is a potent inhibitor of the enzyme cyclooxygenase used as analgesic agent with anti-inflammatory and antipyretic activity.

S4295

Meclofenamate Sodium

Meclofenamate Sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea.