ドーパミン受容体

信号経路図

研究分野

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S2493 Olanzapine <1 mg/mL 62 mg/mL 9 mg/mL
S1763 Quetiapine Fumarate <1 mg/mL 36 mg/mL <1 mg/mL
S3163 Benztropine mesylate 81 mg/mL 50 mg/mL 81 mg/mL
S2456 Chlorpromazine HCl 71 mg/mL 71 mg/mL 71 mg/mL
S1444 Ziprasidone HCl <1 mg/mL 90 mg/mL <1 mg/mL
S4732 MPTP hydrochloride 41 mg/mL 20 mg/mL 41 mg/mL
S4631 Prochlorperazine dimaleate salt <1 mg/mL 74 mg/mL 2 mg/mL
S4731 Perphenazine <1 mg/mL 74 mg/mL 74 mg/mL
S2452 Amfebutamone (Bupropion) HCl <1 mg/mL 8 mg/mL <1 mg/mL
S1726 Levodopa <1 mg/mL <1 mg/mL <1 mg/mL
S3201 Trifluoperazine 2HCl 96 mg/mL 88 mg/mL 96 mg/mL
S2461 Domperidone <1 mg/mL 48 mg/mL 1 mg/mL
S2451 Amantadine HCl 38 mg/mL 38 mg/mL 38 mg/mL
S1280 Amisulpride <1 mg/mL 73 mg/mL 73 mg/mL
S1724 Paliperidone <1 mg/mL 4 mg/mL <1 mg/mL
S1920 Haloperidol <1 mg/mL 75 mg/mL 8 mg/mL
S2011 Pramipexole 2HCl Monohydrate 60 mg/mL 41 mg/mL <1 mg/mL
S1771 Chlorprothixene <1 mg/mL 6 mg/mL 28 mg/mL
S4251 Phenothiazine <1 mg/mL 40 mg/mL <1 mg/mL
S4096 Droperidol <1 mg/mL 76 mg/mL <1 mg/mL
S3044 Lurasidone HCl <1 mg/mL 1 mg/mL <1 mg/mL
S2104 Levosulpiride <1 mg/mL 69 mg/mL <1 mg/mL
S2460 Pramipexole <1 mg/mL 42 mg/mL 42 mg/mL
S2529 Dopamine HCl 38 mg/mL 38 mg/mL <1 mg/mL
S4086 Loxapine Succinate <1 mg/mL 89 mg/mL 2 mg/mL
S4000 Pergolide Mesylate 82 mg/mL 10 mg/mL <1 mg/mL
S4569 Fluphenazine (dihydrochloride) 100 mg/mL 100 mg/mL 30 mg/mL
S4618 Fenoldopam (mesylate) <1 mg/mL 80 mg/mL <1 mg/mL
S7993 SKF38393 HCl <1 mg/mL 58 mg/mL 6 mg/mL
S4151 Penfluridol <1 mg/mL 100 mg/mL 100 mg/mL
S2437 Rotundine <1 mg/mL 8 mg/mL <1 mg/mL
S1642 Methyldopa <1 mg/mL 2 mg/mL <1 mg/mL
S4639 Brexpiprazole <1 mg/mL 24 mg/mL <1 mg/mL
S4257 Alizapride HCl 70 mg/mL 42 mg/mL <1 mg/mL
S4655 Sulpiride <1 mg/mL 68 mg/mL <1 mg/mL
S1789 Tetrabenazine (Xenazine) <1 mg/mL 58 mg/mL 32 mg/mL
S2168 PD128907 HCl 50 mg/mL 12 mg/mL <1 mg/mL
S4219 Azaperone <1 mg/mL 65 mg/mL 34 mg/mL
S8097 C-DIM12 <1 mg/mL 71 mg/mL 71 mg/mL
S4274 Rotigotine <1 mg/mL 63 mg/mL 63 mg/mL
S4289 Metoclopramide HCl 67 mg/mL 67 mg/mL 67 mg/mL
S3189 Ropinirole HCl 60 mg/mL 10 mg/mL <1 mg/mL
S3188 (+,-)-Octopamine HCl 38 mg/mL 38 mg/mL 11 mg/mL

亜型選択性的な製品

製品コード 製品説明 文献中の使用例 お客様のフィードバック
S2493

Olanzapine

Olanzapineは一種の高度親和力の5-HT2セロトニン(serotonin)とD2ドパミンの受容体拮抗剤です。

S1763

Quetiapine Fumarate

Quetiapine Fumarate is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression.

S3163

Benztropine mesylate

Benztropine mesylate is a dopamine transporter (DAT) inhibitor with IC50 of 118 nM.

S2456

Chlorpromazine HCl

Chlorpromazine HCl is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for nward-rectifying K+ currents and time-independent outward currents

S1444

Ziprasidone HCl

Ziprasidone HClは一種の新たで、有効なドパミンとセロトニン(5-HT)の受容体拮抗剤ですが、精神分裂症と双極性障害の治療に使用します。

S4732

MPTP hydrochloride

S4631

Prochlorperazine dimaleate salt

S4731

Perphenazine

S2452

Amfebutamone (Bupropion) HCl

Amfebutamone (Bupropion) HCl is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4μM for the reuptake of dopamine and norepinephrine, respectively

S1726

Levodopa

Levodopa (Sinemet) is an amino acid precursor of dopamine with antiparkinsonian properties.

S3201

Trifluoperazine 2HCl

Trifluoperazine 2HCl is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM.

S2461

Domperidone

Domperidone is a dopamine blocker and an antidopaminergic reagent.

S2451

Amantadine HCl

Amantadine HCl is used to treat or prevent infections of the respiratory tract caused by a certain virus.

S1280

Amisulpride

Amisulpride is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder.

S1724

Paliperidone

Paliperidone is an atypical antipsychotic.

S1920

Haloperidol

Haloperidol (Haldol) is an antipsychotic and butyrophenone.

S2011

Pramipexole 2HCl Monohydrate

Pramipexole 2HCl Monohydrate is a partial/full D2S, D2L, D3, D4, receptor agonist with a Ki of 3.9, 2.2, 0.5, 5.1 nM.

S1771

Chlorprothixene

Chlorprothixeneとドーパミンとヒスタミン受容体が強いと力を合わせて、例えば D1, D2, D3, D5, H1, 5-HT2, 5-HT6 、 5-HT7. Kiはそれぞれ18nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM 、5.6 nMとなる.

S4251

Phenothiazine

Phenothiazine is dopamine-2 (D2) receptor antagonists therefore decrease the effect of dopamine in the brain.

S4096

Droperidol

Droperidol is a potent antagonist of dopamine subtype 2 receptors in the limbic system.

S3044

Lurasidone HCl

Lurasidone HCl is an atypical antipsychotic, inhibits Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively.

S2104

Levosulpiride

Levosulpiride is a selective antagonist for D2 dopamine receptors used as an antipsychotic and prokinetic agent.

S2460

Pramipexole

Pramipexole is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.

S2529

Dopamine HCl

Dopamine HCl is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist.

S4086

Loxapine Succinate

Loxapine Succinateは一種のD2DRとD4DRの阻害剤で、一種のセロトニン系の受容体拮抗剤で、一種のジベンゾキサゼピン(Dibenzoxazepine)類の抗精神病の試薬です。

S4000

Pergolide Mesylate

Pergolide Mesylateは、 作用薬として機能する抗パーキンソン症候群エージェントです。

S4569

Fluphenazine (dihydrochloride)

Fluphenazine( dihydrochloride)はフェノチアジン(phenothiazine)系のD1DR と D2DR の阻害剤です。Fluphenazine( dihydrochloride)はヒスタミン(Histamine)H1受容体を抑制できます。

S4618

Fenoldopam (mesylate)

S7993

SKF38393 HCl

SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.

S4151

Penfluridol

Penfluridolは非常に強力で、第一世代の抗精神病薬であるジフェニル。

S2437

Rotundine

Rotundineは、166nMのIC50による選択的なドーパミンD1受容体拮抗剤です。

S1642

Methyldopa

Methyldopaは一種のDOPAデカルボキシラーゼ(decarboxylase)の競争性的な阻害剤で、 ED50値が21.8 mg/kgです。

S4639

Brexpiprazole

S4257

Alizapride HCl

Alizapride HCl is a dopamine receptor antagonist used for the theropy of nausea and vomiting.

S4655

Sulpiride

Sulpirideは1種のドパミン D2受容体の拮抗剤です。臨床治療の中でSulpirideは抗うつ病剤、抗精神病剤と消化援助剤として使用されます。

S1789

Tetrabenazine (Xenazine)

Tetrabenazine (Nitoman, Xenazine) is a compound for the symptomatic treatment of hyperkinetic movement disorder.

S2168

PD128907 HCl

PD128907 HCl is a drug used in scientific research which acts as a potent and selective agonist for the dopamine D2 and D3 receptors.

S4219

Azaperone

Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic drug with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine.

S8097

C-DIM12

S4274

Rotigotine

Rotigotine is a dopamine receptor agonist, used in the treatment of Parkinson's disease and restless legs syndrome.

S4289

Metoclopramide HCl

Metoclopramide HCl is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.

S3189

Ropinirole HCl

Ropinirole a selective dopamine D2 receptors inhibitor with IC50 of 29 nM.

S3188

(+,-)-Octopamine HCl

Octopamine (OA), a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates.