Doxorubicin (Adriamycin) HCl

Licensed by Pfizer 製品コードS1208 別名:NSC 123127

Doxorubicin (Adriamycin) HCl化学構造

分子量(MW):579.98

Doxorubicin (Adriamycin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.

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JPY 19422.00
JPY 14940.00
JPY 34860.00
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文献中の使用例(33)

カスタマーフィードバック(9)

  • Enhancement of apoptotic response by addition of targeted agents lapatinib and sunitinib to doxorubicin in the same device reservoir at 24 hours. P values were determined using Student’s t test for all graphs.

    Sci Transl Med, 2015, 7(284): 284ra57 . Doxorubicin (Adriamycin) HCl purchased from Selleck.

    (F) Kaplan-Meier curves are shown for all groups described: no hydrogel, a hydrogel loaded with paclitaxel, or a hydrogel loaded with doxorubicin. The number of mice per group (n) and median survival (ms) are listed. The experiment was performed at least three times.

    Science, 2018, 10(433), doi: 10.1126/scitranslmed.aar1916. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • Cell viabilities with increasing concentrations of cisplatin (CP) and doxorubicin (DOXO) under normoxic and hypoxic condition for 48 hours were determined by MTT assay. IC50 values are presented as the means ?SDs (n=4) and * denotes p<0.05.

    Cancer Res 2014 74, 298-308. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    Cleavage of caspase-3, -9 and the expression of PARP were measured by western blot using b-actin as a loading control.

    Cell Cycle, 2017, 16(5):468-476. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • (C) & (D) Treatments with doxorubicin, cisplatin or AZD6244 further decreased the cell viability in RH30 cloned cells in which STAT3 or GP130 was knockdown by shRNA. (*P<.05, ** P <.01, *** P <.001).

    Curr Cancer Drug Targets, 2016, 16(7):631-8. Doxorubicin (Adriamycin) HCl purchased from Selleck.

     

    Doxorubicin release of P(MAA-g-EG) and P(MAA-g-EG) containing nanoparticles in two-step pH conditions. Doxorubicinloaded P(MAA-g-EG) ,P(MAA-g-EG)-1.0NP ,P(MAA-g-EG)-2.5NP, and P(MAA-g-EG)-5.0NP crushed particles (75–150 um) were released in 1 PBS (pH 2.0) for 90 min. Then the pH was increased to 7.0 by adding 5N NaOH and release continued for 6 h.

    J Biomed Mater Res Part A 2012 10.1002/jbm.a.34064. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • Temporal uptake of free DOX or DOX-PCL63-b-PNVP90 micelles into K-562 (I) and DL (J) cells were studied by incubating in 24-well plates at a concentration of 50,000 cells per well. Representative images shown were obtained using a fluorescence microscope Eclipse 80i (Nikon, Japan) (Plan Fluor, 40X, NA 0.75 objective) equipped with blue and red filters for, Hoechst and Doxorubicin respectively (n = 3).

    PLoS One 2014 9, e94309. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    PLoS One 2013 8(1), e54595. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • CON+ -positive control (with FBS as chemoattractant); CON- - negative control (without chemoattractant); DOX -doxorubicin; WZ -WZ811; PF- PF-573228; * -significant difference compared to positive control: p<0.05; ** -significant difference compared to positive control: p<0.01; # -significant difference between combination and inhibitor only: p<0.05. Cancer cell invasion was analyzed using Transwell membranes assembled in 24-well plates and covered with a layer of Matrigel. COR-L23 cells were treated for 24 h with 50 nM DOX, 10 uM WZ811, 5 uM PF-573228 and combinations of inhibitors with 50 nM DOX. Similarly, RH460 cells were treated for 24 h with 1 uM DOX, 10 uM WZ811, 2.5 uM PF-573228 and combinations of inhibitors with 1 uM DOX. Applied doses were the ones that exerted the most pronounced synergistic effect on cytotoxicity level. After the incubation period, cells that invaded through matrigel and membranes were fixed in 4% paraformaldehyde-PBS and stained with Hoechst 33342 nuclear stain. Cells were visualized and counted under a fluorescent microscope at 10x magnification.

    2014 Dr Milica Pesic from Institute for Biological Research. Doxorubicin (Adriamycin) HCl purchased from Selleck.

製品安全説明書

Topoisomerase阻害剤の選択性比較

生物活性

製品説明 Doxorubicin (Adriamycin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.
ターゲット
Topo II [1]
(Tumor cells)
体外試験

Doxorubicin, an antibiotic anthracycline, is commonly considered to exert its anti-tumor activity at two fundamental levels, altering DNA and producing free radicals to trigger apoptosis of cancer cells through DNA damage. Doxorubicin can block the synthesis of DNA by intercalating into the DNA strand, and inhibits DNA topoisomerase II (TOP2). Doxorubicin is most effective when cells are rapidly proliferating and expressing high levels of TOP2. Additionally, Doxorubicin can trigger apoptosis by producing ceramide (which prompts apoptosis by activating p53 or other downstream pathways such as JNK), the degradation of Akt by serine threonine proteases, the mitochondrial release of cytochrome c, increased FasL (death receptor Fas/CD95 ligand) mRNA production, and a greater production of free radicals. [2] Pre-treatment with GSNO (nitrosoglutathione) suppresses the resistance in the doxorubicin-resistant breast cancer cell line MCF7/Dx, accompanied by enhanced protein glutathionylation and accumulation of doxorubicin in the nucleus. [3] Doxorubicin induced G2/M checkpoint arrest are attributed to elevated cyclin G2 (CycG2) expression and phospho-modification of proteins in the ataxia telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) signaling pathways. [5] Doxorubicin inhibits AMP-activated protein kinase (AMPK), resulting in SIRT1 dysfunction, p53 accumulation, and increased cell death in mouse embryonic fibroblasts (MEFs) and cardiomyocytes, which can be further sensitized by pre-inhibition of AMPK. [6] Doxorubicin elicits a marked heat shock response, and that either inhibition or silencing of heat shock proteins enhance the Doxorubicin apoptotic effect in neuroblastoma cells. Nanomolar Doxorubicin treatment of neuroblastoma cells causes dose-dependent over-ubiquitination of a specific set of proteins in the absence of measurable inhibition of proteasome, and loss of activity of ubiquitinated enzymes such as lactate dehydrogenase and α-enolase, the protein ubiquination patterns of which is similar to those with proteasome inhibitor Bortezomib, indicating that Doxorubicin may also exert its effect by damaging proteins. [8]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
L1210 M3P6b2Z2dmO2aX;uJGF{e2G7 MnTjTY5pcWKrdHnvckBw\iCUTlGgd5lvfGinc3nzJJdqfGhiRVS1NEBw\iByLkW4JO69VQ>? MWi0PVA2OzZ?
Yoshida sarcoma M13yfWZ2dmO2aX;uJGF{e2G7 MVLJcohq[mm2aX;uJI9nKFt|SG3U[HIhcW6lb4Lwc5JifGmxbjD3bZRpKEmFNUCgc4YhOC5yMjFOwG0> NYPzZ4NHOTN{Mkm4Oi=>
CHO NHLTRmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHJSYFKSzVyPUCuNFYh|ryP M{HublE{PTR5NUC=
8226 MmXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnxcVlKSzVyPUCuNFM{KM7:TR?= M1fEZlE1PDd5M{C=
8226/ADR MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HUU2lEPTB;MD61OkDPxE1? Mn;sNVQ1Pzd|MB?=
MCF7/ADR MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjsV|FKSzVyPUOuNUDPxE1? NVS3SIdDOTR2N{ezNC=>
H69 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwOEeg{txO NITGNJEyPDd7NUi1
N417 NI\1PXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGL3SYpKSzVyPUCuNlMh|ryP M3LWNlE1Pzl3OEW=
H9 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXi1XldIUW6qaXLpeIlwdiCxZjDIPUBk\WyuczDjbJJwdmmlYXzsfUBqdm[nY4Tl[EB4cXSqIITo[UBJUVZvMTCoTFkwUUmLQjmge4l1cCCLREWwJI9nKDBwMEGg{txO MUWxOVQ5Pjhz
T-C8166 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYr5W4x7UUR3ME2wMlAyKM7:TR?= M3XYNVE2PDh4OEG=
T-H9 NXLKd2VCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnBZWJKTDVyPUCuNFEh|ryP MknHNVU1QDZ6MR?=
T-MT4 M{XLcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnFellqUUR3ME2wMlAyKM7:TR?= MXqxOVQ5Pjhz
SKMEL-5 M4mzNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TYfmVFPTB;Mz6yJO69VQ>? MnmwNVYyOzd3Mx?=
MLM NEfsdpFEgXSxdH;4bYMhSXO|YYm= NXfVfJM3TUR3ME2wMlE{KM7:TR?= MWGxPFc2OzVy
KBM-3 NGXv[3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLscpRiUUN3ME2wMlAzPiEQvF2= MXexPVk2QDd5
HT-29 Mmm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4m5blAvODFizszn Mly3OFghcA>? MXXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eR?= NYW0VGZLOjd5OES0PS=>
EMT6 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvnOlkxNjVizszN NVzO[Yw6OSCq MlP4TY5pcWKrdHnvckBw\iCycn;sbYZmemG2aX;uJIJ6KG2nYYP1dolv\yCob4Kgd5Vzfmm4aX7nJIZz[WO2aX;ud{B4cXSqIFXEOVAhd2ZiMD6wNFAyKM7:TR?= NVr5cWNVPzR3Mk[3OC=>
H2981 MX\DfZRwfG:6aXOgRZN{[Xl? MoXzTWM2OD1yLkWg{txO MkjYO|c{OTB{Mx?=
LOX M{nJfWN6fG:2b4jpZ{BCe3OjeR?= M1;IUWlEPTB;MD6wOFIh|ryP NVHEd4lIPzh3M{OzNS=>
C38 Mlu4R5l1d3SxeHnjJGF{e2G7 NYfDdnM4UUN3ME2wMlAyKM7:TR?= NEHS[YI5ODV5Mkmx
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SKVLB M1HLUGN6fG:2b4jpZ{BCe3OjeR?= NUTNUHVYUUN3ME21MlYh|ryP MnjoPFU4PjlzNB?=
AUC375 MmrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMUGyJO69VQ>? NWHDVnd1QDZ2OE[wNC=>
A2780-C25 MnTiR5l1d3SxeHnjJGF{e2G7 MoPOR5l1d3SxeHnjbZR6KGGpYXnud5Qhd3ijbHnwcIF1cW5vcnXzbZN1[W62IFGyO|gxNUN{NTD3bZRpKEmFNUCgc4YhOC5yNkOg{txO NWPrXXJUQDh|MUe1OS=>
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MXF7 NIK1[4lEgXSxdH;4bYMhSXO|YYm= NVn6VlIySW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5Qhe2Wwc3n0bZZmKE2[Rkege4l1cCCLQ{WwJI9nKDBwMEK4JO69VQ>? MU[4PVYxPTV6
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MCF MVfGeY5kfGmxbjDBd5NigQ>? NYPqXI5nWmW4ZYLzZYwhd2ZiUD3ndE1u\WSrYYTl[EBufWy2aXTyeYchemW|aYP0ZY5k\SCjc4Pld5Nm\CCjczDlcohidmOnbXXueEBqdiCleYTveI95cWOrdImgc4Yh[WS{aXHtfYNqdg>? M4jTR|g6QDRzNUG=
C6 MUHDfZRwfG:6aXOgRZN{[Xl? M17vRVIvPSCvZz;tUC=> MkSxO|IhcA>? M3;BemROW09? NYLrRnNMS3m2b4TvfIlkcXS7IHHnZYlve3RicnH0JGM3KGOnbHzzJIF1KDVyIIXnM41NKHSxIEKuOUBu\y:vTB?= MVe4PVg5PjB2
C6 MkPNSpVv[3Srb36gRZN{[Xl? NHPpS20zNjVibXevcWw> NUfXdJc5PCCq NHnBXWdFVVOR NEP4bZVKdmirYnn0bY9vKG:oIIT1ZpVtcW5icH;sfY1memm8YYTpc44> MkfpPFk5QDZyNB?=
C6 MWDDfZRwfG:6aXOgRZN{[Xl? NY\4flNPOi53IH3nM41N Ml\VOUBp MVLEUXNQ MlexR5l1d3SxeHnjbZR6KGG|c3Xzd4VlKGG|IHPlcIwhemWuZXHz[S=> MmfxPFk5QDZyNB?=
SKVLB MWnDfZRwfG:6aXOgRZN{[Xl? M4rkO|czKGh? NXT2bHlRUUN3ME22MlU1KM7:TR?= MoLxPVAxOzV{MB?=
MCF7/VP16 MV7DfZRwfG:6aXOgRZN{[Xl? M2XWdVUxKM7:Zz;tUC=> MVu3NkBp M4jqRWlEPTB;MUSuNkDPxE1? M1nGWlkxOjJ5OUK=
CA755 M3\iTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPFbWVPOTBizszN MVW2JIQ> M4fhXWlEPTB;MD6wNVQh|ryP M4HhdVk2OjZ3N{C=
CHO NUjFZ2wzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWKxNEDPxE1? M4rVVVYh\A>? M{DWRWlEPTB;MD6wOkDPxE1? MnjFPVUzPjV5MB?=
Panc02 MlzuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmf1NVAh|ryP MlXZOkBl M4fHRmlEPTB;MD6wOlUh|ryP NGTCVnU6PTJ4NUew
PC14 NYfaZppNS3m2b4TvfIlkKEG|c3H5 MYi0JIQ> M{jmTGROW09? M1TrXGlEPTB;MD6yPUDPxE1? M3;3N|k5OjJ3NEK=
HOP62 MWXDfZRwfG:6aXOgRZN{[Xl? MYG3NkBp MWfJR|UxRTBwMEC0JO69VQ>? M3zoTlk5PzN4NkG=
SF-295 NY\hSXJ4S3m2b4TvfIlkKEG|c3H5 Mlv2O|IhcA>? MoOyTWM2OD1yLkCzOUDPxE1? MXO5PFc{PjZz
MDA-MB-361 NVjYb41ZS3m2b4TvfIlkKEG|c3H5 M2XxSVEhcA>? Mmn0SG1UVw>? MXvDfZRwfG:6aXPpeJkh[WejaX7zeEBOTEFvTVKtN|YyKGW6cILld5NqdmdiTHHjXkB4cXSqIFnDOVAhd2ZiMD6wNVIh|ryP NUTobnZVOTB|OUW0PVA>
MDA-MB-361 NF3nOJBEgXSxdH;4bYMhSXO|YYm= MVuxJIg> M{Ts[mROW09? NXXOfVM4S3m2b4TvfIlkcXS7IHHnZYlve3RiTVTBJG1DKDN4MTDlfJBz\XO|aX7nJINiemKxeInw[ZB1cWSjc3Wgd5REWEd{IIfpeIghUUN3MDDv[kAxNjBzODFOwG0> M1:4WlExOzl3NEmw
CCRF-SB MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmi1OEBl Mm\RSG1UVw>? M1zDNGlEPTB;MD6wNUDPxE1? M{jC[VExPDFzNEe2
CHO-K1 NUfxenBNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFP3TJU1KGR? NVHuPYJCTE2VTx?= Mm\aTWM2OD1yLkSg{txO M{nv[|ExPDFzNEe2
KB NX\kXGxYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\6OEBl MnLGSG1UVw>? NXXxc3FySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBlenWpLYLld4l{fGGwdDDLRldFKHerdHigTWM2OCCxZjCwMlY2KM7:TR?= MVGxNFQyOTR5Nh?=
KB MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\nR|Qh\A>? MnHCSG1UVw>? NWm3RZRpSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBlenWpLYLld4l{fGGwdDDLRmNidXC5aYToJGlEPTBib3[gNE4xPiEQvF2= MoXJNVA1OTF2N{[=
KB MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFH6bY41KGR? NYf6e3J2TE2VTx?= NWfmU4htSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBlenWpLYLld4l{fGGwdDDLRm1FWiC5aYToJGlEPTBib3[gNE42KM7:TR?= NU\DWYJuOTB2MUG0O|Y>
KB M4H2R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fSbVQh\A>? NHX6e|FFVVOR M3z1WGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4Sg[JJ2\y2{ZYPpd5RidnRiS1LWNlBEKHerdHigTWM2OCCxZjCwMlQh|ryP NUDxTZlEOTB2MUG0O|Y>
HTB-54 Ml;XR5l1d3SxeHnjJGF{e2G7 M1Ly[lExOCEQvF2= NVjjS|IyUUN3ME2xMlEh|ryP NGnZPYIyODR5Nki2NS=>
MEL-AC M4TKWmN6fG:2b4jpZ{BCe3OjeR?= NIDuc4QyODBizszN MYfJR|UxRTFwMjFOwG0> MUGxNFQ4Pjh4MR?=
DU145 NYK1cnZuS3m2b4TvfIlkKEG|c3H5 NFT3cIw4OiCq NYf4OJpkUUN3ME2wMlA2OjhizszN M1HOblExPDd7Mkiy
K562R MXfDfZRwfG:6aXOgRZN{[Xl? MWK3NkBp M3zlWWlEPTB;MD6wNVU3KM7:TR?= NH;MXYQyODR5OUK4Ni=>
PACA-2 NGjyZ|BEgXSxdH;4bYMhSXO|YYm= NWG4coJNPiCm M1jlOWVFPTB;MD6wNFY{KM7:TR?= M3vLZVExPDl6MkG0
3Y1 MmPIR5l1d3SxeHnjJGF{e2G7 M4m3[FczKGh? MUjHTVUxRTBwMECzPEDPxE1? MlnRNVA3QTF5MUC=
P388 Ml7HR5l1d3SxeHnjJGF{e2G7 NFf3Tpc4OiCq NEPqNppIUTVyPUCuNFEzKM7:TR?= NW\lb|RSOTB4OUG3NVA>
HMV-1 MnrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HtUWlEPTB;MD6yPEDPxE1? Ml60NVA3QTh2M{[=
MKN-1 NEPjS|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nzV2lEPTB;MD62OEDPxE1? MlfzNVA3QTh2M{[=
PC14 NUjYOJp7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TRZ2lEPTB;MT65JO69VQ>? MYCxNFY6QDR|Nh?=
T24 MonUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwNkSg{txO NIfnUnEyODZ7OESzOi=>
U937 MlrFSpVv[3Srb36gRZN{[Xl? NYniZYpvOjRiaB?= MmfMSG1UVw>? NHTOU5JKdmirYnn0d{BqdmOxcoDvdoF1cW:wIH;mJHs{UF22aIntbYRqdmVid3n0bEBKSzVyIH;mJFAvOSEQvF2= MUixNFc5ODlzMR?=
H460pv8/eto NYe0XHpLS3m2b4TvfIlkKEG|c3H5 NEHTdYEyODBizszN MUC0PEBp Ml7XV4FtcW6n M375UWlEPTB;MD6wNkDPxE1? MnjNNVA4QDB7MUO=
H460pv8 NXnRV5pRS3m2b4TvfIlkKEG|c3H5 NYfTT5Y2OTByIN88US=> M33kb|Q5KGh? NH;a[YpU[WyrbnW= NXfNbG5TUUN3ME2wMlAxPCEQvF2= NUnSfFlXOTB5OEC5NVM>
MDA-231 NIjsWG9EgXSxdH;4bYMhSXO|YYm= M3ywcFExOCEQvF2= MX:0PEBp M2fiPXNidGmwZR?= M{j0SWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2GQT2yN|Eh[2WubDCoSXIuNEWJRmKrMI12fGGwdDDwOVMqKHerdHigTWM2OCCxZjCwMlAxPiEQvF2= NFzvPXEyODd6MEmxNy=>
MDA-468 NULFTog5S3m2b4TvfIlkKEG|c3H5 NF7YXYoyODBizszN NFjmVmQ1QCCq MXrTZYxqdmV? M4\EWGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2GQT20Olgh[2WubDCoSXIuNCCjbYDsbYZq\WRiRVfGVkwhdXW2YX70JJA2Oylid3n0bEBKSzVyIH;mJFAvODB3IN88US=> MlvjNVA4QDB7MUO=
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NCI-H748 M{HMXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTF2Nz6zNUBvVQ>? NIrS[YdUSU6JRWK=
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LU-65 NV;lZZlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHzWo97UUN3ME2zOFYvPCCwTR?= NHnvc3JUSU6JRWK=
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SW1417 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LiVmlEPTB;M{[zMlI{KG6P MUfTRW5ITVJ?
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HT MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{mwOWlEPTB;NEC1MlE2KG6P M1f2bHNCVkeHUh?=
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LB2518-MEL NIfFVFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{n3UWlEPTB;NEGzMlEhdk1? MUPTRW5ITVJ?
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NCI-H226 NFz3NHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TMOWlEPTB;NEG2MlY1KG6P NFHJSlNUSU6JRWK=
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UACC-893 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrGcpBmUUN3ME21NlEvPTFibl2= NU\o[3BJW0GQR1XS
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NCI-H1563 NGL4cGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XRfGlEPTB;NUW2MlQ6KG6P M4r3b3NCVkeHUh?=
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NCI-H69 NX\aWmNkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjPU2ZuUUN3ME21OlgvQCCwTR?= M1i3cnNCVkeHUh?=
NCI-SNU-5 MoW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjsTWM2OD13N{CuNVUhdk1? NWiwbndUW0GQR1XS
NCI-H1792 M2DRe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTKXnNIUUN3ME21O|IvPDNibl2= MUDTRW5ITVJ?
NCI-H2141 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHLbXZKSzVyPUW3N{43QSCwTR?= MVTTRW5ITVJ?
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NCI-H1623 M1njNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljMTWM2OD14MESuOkBvVQ>? MYLTRW5ITVJ?
MN-60 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTZyNT6zO{BvVQ>? Mn3TV2FPT0WU
JAR M3PWbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvsTWM2OD14MkWuPVUhdk1? M1jTXnNCVkeHUh?=
HCC1419 NIXPPW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY[wXlFDUUN3ME22N|EvPzRibl2= NFLyS45USU6JRWK=
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TYK-nu NHPme41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTQVIFoUUN3ME22OlIvPTVibl2= MWLTRW5ITVJ?
DG-75 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrBTWM2OD14NkWuPFMhdk1? MlLaV2FPT0WU
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MKN7 MmfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTZ6OT65OUBvVQ>? MWnTRW5ITVJ?
DMS-153 M3PRemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jSXWlEPTB;Nkm4MlE2KG6P NVPiVYRwW0GQR1XS
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GCIY M1e1Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjGUI9KSzVyPUeyOU4yOiCwTR?= MonuV2FPT0WU
NCI-H1092 NF7oNGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnv4TWM2OD15M{euPVUhdk1? NEPDbHJUSU6JRWK=
EB-3 Mn\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTyPVRsUUN3ME23O|EvODJibl2= NHewVpFUSU6JRWK=
CAL-120 NUPofYJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{O4SmlEPTB;N{e3MlUzKG6P NInhWI9USU6JRWK=
BT-474 NEHNenNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHmd4JKSzVyPUe3PE45OSCwTR?= MX;TRW5ITVJ?
L-428 NHflS45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvQXG1sUUN3ME23PVAvQSCwTR?= MnLEV2FPT0WU
Mo-T M3rTNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRThyND62OUBvVQ>? MV;TRW5ITVJ?
CAL-72 NHO3d3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIO4PZlKSzVyPUi0NE43PyCwTR?= NWXlUYRjW0GQR1XS
AsPC-1 Ml\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7JVWtKSzVyPUi1OU4zPiCwTR?= MWjTRW5ITVJ?
U-118-MG MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDnV21iUUN3ME24OVYvOzRibl2= MWHTRW5ITVJ?
GCT NUnkZ|lJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnoOWs{UUN3ME24OlEvPDhibl2= MoHoV2FPT0WU
EKVX NHfKTY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTh5MT64O{BvVQ>? MY\TRW5ITVJ?
NCI-H1755 Mkn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHGWXlKSzVyPUi3N{42OiCwTR?= NHrG[4tUSU6JRWK=
Capan-2 M{\lSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfNfnNKSzVyPUi5PE4yOSCwTR?= M4XJO3NCVkeHUh?=
NCI-H1793 M33IU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzPZVFtUUN3ME25NFAvQDdibl2= NWf0[ZpoW0GQR1XS
PLC-PRF-5 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVW2eGxmUUN3ME25NFEvOzVibl2= M1yyNnNCVkeHUh?=
M14 MkDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTlyNT6yO{BvVQ>? NET1XYZUSU6JRWK=
SK-MEL-24 MmLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\OT2dKSzVyPUmxOE4{PSCwTR?= NIfQOYxUSU6JRWK=
SK-MM-2 Ml7MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTl2Mj6zJI5O Mk\zV2FPT0WU
PC-3 NF[0TmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTl3Nz6yNkBvVQ>? M4ficXNCVkeHUh?=
EW-24 NV7Ge2JtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDITWM2OD17N{CuOEBvVQ>? NF3w[XlUSU6JRWK=
MDA-MB-175-VII NXfEZok4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrBb2VKSzVyPUm3NU42OyCwTR?= NVLicm9pW0GQR1XS
NCI-H1581 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfMTWM2OD17OEGuN|Ehdk1? M1j1UXNCVkeHUh?=
THP-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTl6OT60NkBvVQ>? NXXte29qW0GQR1XS
NCI-H1993 NHjPS49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlX5TWM2OD1zLkCwNFc3KM7:TR?= MX;TRW5ITVJ?
DOK NW\GRllmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXKSVNCUUN3ME2xMlAyPzZ{IN88US=> NIX3XIFUSU6JRWK=
KINGS-1 MoXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13MU2lEPTB;MT6wNVkh|ryP M1;2OHNCVkeHUh?=
YT NFTKW|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\BdG5KSzVyPUGuNFQ2PjhizszN MnrmV2FPT0WU
TGBC1TKB NYPONYZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{WweWlEPTB;MT6wOlA{PiEQvF2= MmLTV2FPT0WU
TCCSUP M2TXSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTFwMkOwPFMh|ryP MnLoV2FPT0WU
BEN MkX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTFwMkO3OFIh|ryP MlTiV2FPT0WU
KARPAS-45 NF;peXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHza[YhKSzVyPUGuNlY4PjNizszN MYDTRW5ITVJ?
COLO-829 MmjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rmZ2lEPTB;MT6yO|Q5KM7:TR?= M2[zenNCVkeHUh?=
UACC-62 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW[zXG06UUN3ME2xMlMzOTR3IN88US=> M4TPXnNCVkeHUh?=
NCI-H446 M1vFeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\he2lEPTB;MT6zN|c4OSEQvF2= MmjiV2FPT0WU
RO82-W-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDrbJVKSzVyPUGuN|Q{OzdizszN MnHVV2FPT0WU
NCI-H2452 NF:xc2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTFwM{exNlkh|ryP Moj5V2FPT0WU
RL Mm[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTFwNEKwOlYh|ryP M2n0fHNCVkeHUh?=
NCI-H1522 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHz3fmtKSzVyPUGuOFMyPTlizszN NEPNc4ZUSU6JRWK=
TGW NVrPUoFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTFwNEW5OFIh|ryP M1;acnNCVkeHUh?=
HT55 M1z5TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTFwNEexOlgh|ryP MV;TRW5ITVJ?
KARPAS-299 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjZTWM2OD1zLkS3PFQyKM7:TR?= NFOxc|dUSU6JRWK=
KY821 Mn7qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zvd2lEPTB;MT60PVQzQSEQvF2= MWHTRW5ITVJ?
MDA-MB-231 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mny1TWM2OD1zLkWzNFU2KM7:TR?= MUPTRW5ITVJ?
NCI-H82 MkjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M16wc2lEPTB;MT61O|AzPiEQvF2= NWqxNoNuW0GQR1XS
MDA-MB-134-VI NVfkcGh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHOUXNKSzVyPUGuOlE4OTFizszN Mo\iV2FPT0WU
PANC-08-13 NH3U[YVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTFwNkOwPFQh|ryP MXHTRW5ITVJ?
D-542MG MoDHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37ET2lEPTB;MT62OVMxPSEQvF2= NYnVOW1PW0GQR1XS
LC-1F NWjNPHVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnJXWtKSzVyPUGuOlYzODNizszN Mn6yV2FPT0WU
KP-N-YN Mk\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTFwNk[zOFMh|ryP NWPsTYtZW0GQR1XS
MFE-280 MlKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DrW2lEPTB;MT62OlgyOiEQvF2= MoLiV2FPT0WU
S-117 MoPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17PdmlEPTB;MT63NFUxPCEQvF2= Mn3qV2FPT0WU
NCI-H1573 NHnaWXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rEUWlEPTB;MT63NVc{OyEQvF2= NInuT|JUSU6JRWK=
BT-20 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTFwN{SwOlgh|ryP M3\YUHNCVkeHUh?=
NCI-H28 M2HvOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17lTmlEPTB;MT63OFA4QCEQvF2= MVPTRW5ITVJ?
CaR-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\6TWM2OD1zLke4N|I1KM7:TR?= NYPEVFNKW0GQR1XS
LN-405 NXHqbJIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTFwOECxOFMh|ryP NI[2SYZUSU6JRWK=
RT4 NIL2Rm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYflV4o4UUN3ME2xMlg1PDF5IN88US=> M{jKdHNCVkeHUh?=
NCI-H889 NXL2Z4k5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX[xdXlxUUN3ME2xMlk{QDh4IN88US=> MkPLV2FPT0WU
SW1463 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjKNHFKSzVyPUGuPVU4ODFizszN NHK5cWZUSU6JRWK=
SCLC-21H M4jNRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIqwOVhKSzVyPUKuNFA3OjRizszN MmXjV2FPT0WU
CP66-MEL MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4OwTmlEPTB;Mj6wNVc3PyEQvF2= NVviR3o4W0GQR1XS
Hs-578-T MkHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTJwMEG3PFIh|ryP NXP5ZmlLW0GQR1XS
HCC70 M{CwOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDjbW5KSzVyPUKuNFU1PjNizszN MUHTRW5ITVJ?
SW1088 Mnf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1v2UmlEPTB;Mj6wOlk{OSEQvF2= NYTP[IF5W0GQR1XS
NB6 Mn:4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFKwOFBKSzVyPUKuNVg2KM7:TR?= MV\TRW5ITVJ?
KU-19-19 MojjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTJwMk[5NVch|ryP NH31WolUSU6JRWK=
A704 NFHEWGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjSTWM2OD1{LkK5NVM2KM7:TR?= NInIOnRUSU6JRWK=
EVSA-T M{DMdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTJwM{CwPFkh|ryP MV7TRW5ITVJ?
HCT-15 M1Tsfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{f2d2lEPTB;Mj6zOVQ3PiEQvF2= M1zW[XNCVkeHUh?=
HuO-3N1 NWnPe|d{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrKXYxKSzVyPUKuN|Y2QDNizszN NV\XfWxDW0GQR1XS
GMS-10 MnnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjFSIlKSzVyPUKuN|k4OzhizszN NHLaZYRUSU6JRWK=
TGBC24TKB MnfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7we4pjUUN3ME2yMlQyPDJ7IN88US=> MYjTRW5ITVJ?
C2BBe1 NF3lZY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\oTWM2OD1{LkWxN|I5KM7:TR?= MVXTRW5ITVJ?
SK-N-DZ NYTHcHhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHjSYZKSzVyPUKuOVY2QTJizszN NW\3UoNjW0GQR1XS
SK-N-AS MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTJwN{OwNVUh|ryP MmnEV2FPT0WU
T98G MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrWNFRKSzVyPUKuPFA1ODFizszN MVrTRW5ITVJ?
DMS-79 MmH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXHS4Y6UUN3ME2yMlkxQTh6IN88US=> MYfTRW5ITVJ?
SNU-475 NHzUeo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7CcY54UUN3ME2yMlkzPTd{IN88US=> NFrhbZBUSU6JRWK=
COLO-792 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTNwMEK4O{DPxE1? M3[3SXNCVkeHUh?=
YAPC NXzFb2xuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1y4VmlEPTB;Mz6zNlg{OiEQvF2= NVrwTFJDW0GQR1XS
UACC-812 MlLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3L0bWlEPTB;Mz6zN|c{QCEQvF2= NVXUZoZwW0GQR1XS
Mewo MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTNwNE[wPFYh|ryP MmLSV2FPT0WU
COLO-824 MnznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPJ[4Y2UUN3ME2zMlU4Ozd6IN88US=> NFnzS3NUSU6JRWK=
SCC-9 MmHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fJeGlEPTB;Mz65NVMxQSEQvF2= NFXwd2JUSU6JRWK=
CP50-MEL-B M4DySGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rqRmlEPTB;Mz65PFcxOyEQvF2= MVHTRW5ITVJ?
NCI-H345 NVTNd5FGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTRwMEGxO|Qh|ryP MWTTRW5ITVJ?
COR-L88 MlnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTRwM{m1PEDPxE1? MUDTRW5ITVJ?
RCM-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvSTWM2OD12LkS5NlczKM7:TR?= NX\mRW14W0GQR1XS
JVM-3 NXTvTmVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTRwNkC2NVgh|ryP NUn1VY1yW0GQR1XS
ECC4 MkW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LFWGlEPTB;ND63OlU1OSEQvF2= NX:1PXByW0GQR1XS
MDA-MB-453 MmL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfqTWM2OD12Lki1NVM1KM7:TR?= NYPncIp{W0GQR1XS
SK-N-FI MojTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLObmlNUUN3ME21MlIzQDd5IN88US=> NF3DV2JUSU6JRWK=
D-502MG M4T5emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DJUmlEPTB;NT6yOFI3OiEQvF2= NYTDNpJOW0GQR1XS
NCI-H2227 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fnTGlEPTB;NT6zOlI{OSEQvF2= M2nMPXNCVkeHUh?=
DMS-53 M1rpT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTZwMUexNFYh|ryP M121d3NCVkeHUh?=
LB771-HNC MkH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfac4VKSzVyPU[uOFY5ODZizszN NYP3UpFTW0GQR1XS
BB49-HNC M{fpU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DUemlEPTB;Nz60NVc6OSEQvF2= Mn\rV2FPT0WU
MDA-MB-415 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTdwNUezNFMh|ryP MoH1V2FPT0WU
TALL-1 Ml:0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\yXGlEPTB;Nz65Olg5KM7:TR?= NFjPdFlUSU6JRWK=
HCC1395 M2rTdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTSS2pKSzVyPUiuNVUyOjJizszN MUfTRW5ITVJ?
EFE-184 NHHiW5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvnTWM2OD16LkO3NlE3KM7:TR?= M{C1THNCVkeHUh?=
EC-GI-10 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{G1R2lEPTB;OD62PFY5PiEQvF2= MVLTRW5ITVJ?
TT M1rKfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\JTmdKSzVyPUmuNFY6PjZizszN NHruS5VUSU6JRWK=
U-2-OS NYH4OmViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TZT2lEPTB;OT64NVM6OyEQvF2= MYnTRW5ITVJ?
SHP-77 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrHW|BKSzVyPUmuPVAzQSEQvF2= NVvK[|U{W0GQR1XS
HCC1143 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTFyLkS3PVch|ryP NVz4XFJCW0GQR1XS
A498 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlToTWM2OD1zOD6yPVc3KM7:TR?= MUjTRW5ITVJ?
LS-513 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGG2TGVKSzVyPUG4MlYxQTNizszN M2jJe3NCVkeHUh?=
K052 NVLKUpJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3DWG1FUUN3ME2yNU41PDF6IN88US=> NXPi[Hp[W0GQR1XS
SiHa NF7XfnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTJ|LkOzO|Eh|ryP M4nzWXNCVkeHUh?=
RCC10RGB MmHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\iTWM2OD1|MD6wOlEyKM7:TR?= NWDQRZJUW0GQR1XS
NCI-SNU-16 NHH5eFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTNzLkG4N|Yh|ryP M2jEPXNCVkeHUh?=
SNU-C1 NVX0W2h4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTN{LkSxO|Uh|ryP NIrGWZlUSU6JRWK=
C32 NUDGcGhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33uU2lEPTB;M{KuPFczKM7:TR?= NH;zeYJUSU6JRWK=
SW684 MofxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4P0SGlEPTB;M{SuNVU3OSEQvF2= NWi0dplbW0GQR1XS
SK-MEL-28 NWDVV4h4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnXTWM2OD1|NT61N|c4KM7:TR?= NGOwbGpUSU6JRWK=
SK-MEL-1 NUjBRogxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHG0UYZKSzVyPUO2Mlc2PDdizszN NWe1dI91W0GQR1XS
NCI-H720 NHf2To5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\JT|ZxUUN3ME20NU46PzJ4IN88US=> MlzCV2FPT0WU
P31-FUJ M33YNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTR2LkOyPFQh|ryP MoXCV2FPT0WU
NCI-H524 MmC3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTR6LkiyOFgh|ryP MYLTRW5ITVJ?

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

体内試験 In vivo, Doxorubicin in combination with adenoviral MnSOD (AdMnSOD) plus 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) has the greatest effect in decreasing the volumes of MB231 tumors and prolonging survival of mice. [1] Although its use is limited by the chronic and acute toxic side effects it produces, Doxorubicin is essential in treating breast and oesophageal carcinomas, solid tumours in childhood, osteosarcomas, Kaposi's sarcoma, soft tissue sarcomas, and Hodgkin and non-Hodgkin lymphomas. [2]

お薦めの試験操作(参考用のみ)

動物試験:[1]
+ 展開
  • 動物モデル: Female athymic nude mice injected s.c. with MB231 cells
  • 製剤: Dissolved in DMSO, and diluted in saline
  • 投薬量: 3 mg/kg/day
  • 投与方法: Delivered intratumorly
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 100 mg/mL (172.41 mM) warming
Water 20 mg/mL (34.48 mM)
Ethanol Insoluble

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 579.98
化学式

C27H29NO11.HCl

CAS No. 25316-40-9
保管
in solvent
別名 NSC 123127

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03036904 Not yet recruiting Diffuse Large B-Cell Lymphoma|High Grade B-Cell Lymphoma Weill Medical College of Cornell University|Genentech, Inc.|Massachusetts General Hospital|M.D. Anderson Cancer Center February 6, 2017 Phase 1
NCT02659930 Recruiting Kaposi Sarcoma National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) January 4, 2016 Phase 1
NCT03042819 Not yet recruiting Soft Tissue Sarcoma University Health Network, Toronto|Karyopharm Therapeutics, Inc March 27, 2017 Phase 1
NCT03033914 Recruiting Hodgkin Lymphoma Memorial Sloan Kettering Cancer Center|Bristol-Myers Squibb|M.D. Anderson Cancer Center|City of Hope Medical Center January 25, 2017 Phase 1
NCT02957968 Recruiting Locally Advanced Breast Cancer|Invasive Adenocarcinoma of the Breast|Breast Cancer Stage II|Breast Cancer Stage III|Breast Cancer Stage IV Virginia Commonwealth University|Merck Sharp & Dohme Corp.|National Cancer Institute (NCI) January 24, 2017 Phase 2
NCT02377752 Active, not recruiting Neoplasm Eli Lilly and Company March 23, 2015 Phase 1

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    Why the IC50 of the compound varied over time in our measurement?

  • 回答:

    Sometimes the IC50 value might vary between different batch of compounds due to the slight differences in purity. If different IC50 was seen in the same batch of compound, the problem may lies in the process of dissolvement. Make sure that you see no particles and the solution is clear with your stock solution.

Topoisomeraseシグナル伝達経路

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