Doxorubicin (Adriamycin) HCl

Licensed by Pfizer 製品コードS1208 別名:NSC 123127

Doxorubicin (Adriamycin) HCl化学構造

分子量(MW):579.98

Doxorubicin (Adriamycin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.

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文献中の使用例(32)

カスタマーフィードバック(8)

  • Enhancement of apoptotic response by addition of targeted agents lapatinib and sunitinib to doxorubicin in the same device reservoir at 24 hours. P values were determined using Student’s t test for all graphs.

    Sci Transl Med, 2015, 7(284): 284ra57 . Doxorubicin (Adriamycin) HCl purchased from Selleck.

    Cell viabilities with increasing concentrations of cisplatin (CP) and doxorubicin (DOXO) under normoxic and hypoxic condition for 48 hours were determined by MTT assay. IC50 values are presented as the means ?SDs (n=4) and * denotes p<0.05.

    Cancer Res 2014 74, 298-308. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • Cleavage of caspase-3, -9 and the expression of PARP were measured by western blot using b-actin as a loading control.

    Cell Cycle, 2017.. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    (C) & (D) Treatments with doxorubicin, cisplatin or AZD6244 further decreased the cell viability in RH30 cloned cells in which STAT3 or GP130 was knockdown by shRNA. (*P<.05, ** P <.01, *** P <.001).

    Curr Cancer Drug Targets, 2016, 16(7):631-8. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  •  

    Doxorubicin release of P(MAA-g-EG) and P(MAA-g-EG) containing nanoparticles in two-step pH conditions. Doxorubicinloaded P(MAA-g-EG) ,P(MAA-g-EG)-1.0NP ,P(MAA-g-EG)-2.5NP, and P(MAA-g-EG)-5.0NP crushed particles (75–150 um) were released in 1 PBS (pH 2.0) for 90 min. Then the pH was increased to 7.0 by adding 5N NaOH and release continued for 6 h.

    J Biomed Mater Res Part A 2012 10.1002/jbm.a.34064. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    Temporal uptake of free DOX or DOX-PCL63-b-PNVP90 micelles into K-562 (I) and DL (J) cells were studied by incubating in 24-well plates at a concentration of 50,000 cells per well. Representative images shown were obtained using a fluorescence microscope Eclipse 80i (Nikon, Japan) (Plan Fluor, 40X, NA 0.75 objective) equipped with blue and red filters for, Hoechst and Doxorubicin respectively (n = 3).

    PLoS One 2014 9, e94309. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • PLoS One 2013 8(1), e54595. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    CON+ -positive control (with FBS as chemoattractant); CON- - negative control (without chemoattractant); DOX -doxorubicin; WZ -WZ811; PF- PF-573228; * -significant difference compared to positive control: p<0.05; ** -significant difference compared to positive control: p<0.01; # -significant difference between combination and inhibitor only: p<0.05. Cancer cell invasion was analyzed using Transwell membranes assembled in 24-well plates and covered with a layer of Matrigel. COR-L23 cells were treated for 24 h with 50 nM DOX, 10 uM WZ811, 5 uM PF-573228 and combinations of inhibitors with 50 nM DOX. Similarly, RH460 cells were treated for 24 h with 1 uM DOX, 10 uM WZ811, 2.5 uM PF-573228 and combinations of inhibitors with 1 uM DOX. Applied doses were the ones that exerted the most pronounced synergistic effect on cytotoxicity level. After the incubation period, cells that invaded through matrigel and membranes were fixed in 4% paraformaldehyde-PBS and stained with Hoechst 33342 nuclear stain. Cells were visualized and counted under a fluorescent microscope at 10x magnification.

    2014 Dr Milica Pesic from Institute for Biological Research. Doxorubicin (Adriamycin) HCl purchased from Selleck.

製品安全説明書

Topoisomerase阻害剤の選択性比較

生物活性

製品説明 Doxorubicin (Adriamycin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.
ターゲット
Topo II [1]
(Tumor cells)
体外試験

Doxorubicin, an antibiotic anthracycline, is commonly considered to exert its anti-tumor activity at two fundamental levels, altering DNA and producing free radicals to trigger apoptosis of cancer cells through DNA damage. Doxorubicin can block the synthesis of DNA by intercalating into the DNA strand, and inhibits DNA topoisomerase II (TOP2). Doxorubicin is most effective when cells are rapidly proliferating and expressing high levels of TOP2. Additionally, Doxorubicin can trigger apoptosis by producing ceramide (which prompts apoptosis by activating p53 or other downstream pathways such as JNK), the degradation of Akt by serine threonine proteases, the mitochondrial release of cytochrome c, increased FasL (death receptor Fas/CD95 ligand) mRNA production, and a greater production of free radicals. [2] Pre-treatment with GSNO (nitrosoglutathione) suppresses the resistance in the doxorubicin-resistant breast cancer cell line MCF7/Dx, accompanied by enhanced protein glutathionylation and accumulation of doxorubicin in the nucleus. [3] Doxorubicin induced G2/M checkpoint arrest are attributed to elevated cyclin G2 (CycG2) expression and phospho-modification of proteins in the ataxia telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) signaling pathways. [5] Doxorubicin inhibits AMP-activated protein kinase (AMPK), resulting in SIRT1 dysfunction, p53 accumulation, and increased cell death in mouse embryonic fibroblasts (MEFs) and cardiomyocytes, which can be further sensitized by pre-inhibition of AMPK. [6] Doxorubicin elicits a marked heat shock response, and that either inhibition or silencing of heat shock proteins enhance the Doxorubicin apoptotic effect in neuroblastoma cells. Nanomolar Doxorubicin treatment of neuroblastoma cells causes dose-dependent over-ubiquitination of a specific set of proteins in the absence of measurable inhibition of proteasome, and loss of activity of ubiquitinated enzymes such as lactate dehydrogenase and α-enolase, the protein ubiquination patterns of which is similar to those with proteasome inhibitor Bortezomib, indicating that Doxorubicin may also exert its effect by damaging proteins. [8]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
L1210 NHTWNplHfW6ldHnvckBCe3OjeR?= NFf6TVRKdmirYnn0bY9vKG:oIGLORUB{gW62aHXzbZMhf2m2aDDFSFUxKG:oIECuOVgh|ryP MUS0PVA2OzZ?
Yoshida sarcoma MXTGeY5kfGmxbjDBd5NigQ>? NEDFSWlKdmirYnn0bY9vKG:oIGuzTH1V\FJiaX7jc5Jxd3KjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNkDPxE1? NVnsUYZsOTN{Mkm4Oi=>
CHO MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17JdmlEPTB;MD6wOkDPxE1? NXizR5lFOTN3NEe1NC=>
8226 M3Sycmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMEOzJO69VQ>? MXexOFQ4PzNy
8226/ADR NFLzPWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlSwTWM2OD1yLkW2JO69VQ>? NVLWclFROTR2N{ezNC=>
MCF7/ADR M362VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTNwMTFOwG0> NGe0NooyPDR5N{Ow
H69 M4TiSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwOEeg{txO NFi3[XAyPDd7NUi1
N417 M2\aT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMkOg{txO Mn;yNVQ4QTV6NR?=
H9 M2\qS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfjU5FiUW6qaXLpeIlwdiCxZjDIPUBk\WyuczDjbJJwdmmlYXzsfUBqdm[nY4Tl[EB4cXSqIITo[UBJUVZvMTCoTFkwUUmLQjmge4l1cCCLREWwJI9nKDBwMEGg{txO NYrJ[JM6OTV2OE[4NS=>
T-C8166 MojrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojnTWQ2OD1yLkCxJO69VQ>? MV[xOVQ5Pjhz
T-H9 NUX3b3ZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDuTWQ2OD1yLkCxJO69VQ>? MnPlNVU1QDZ6MR?=
T-MT4 MlHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3kTWQ2OD1yLkCxJO69VQ>? MYWxOVQ5Pjhz
SKMEL-5 MoftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHFSFUxRTNwMjFOwG0> NGW5Ro8yPjF|N{Wz
MLM NEPTbWZEgXSxdH;4bYMhSXO|YYm= Mn:xSWQ2OD1yLkGzJO69VQ>? MlXpNVg4PTN3MB?=
KBM-3 NWnySY16T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjnN|l7UUN3ME2wMlAzPiEQvF2= MUexPVk2QDd5
HT-29 NUeyXG8yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LxUFAvODFizszn NGG3Rog1QCCq MmnTRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdIm= MYWyO|c5PDR7
EMT6 M2LKN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIf0flIxNjVizszN NW\EOHhNOSCq NF3DOoVKdmirYnn0bY9vKG:oIIDyc4xq\mW{YYTpc44h[nlibXXhd5VzcW6pIH\vdkB{fXK4aY\pcoch\nKjY4Tpc45{KHerdHigSWQ2OCCxZjCwMlAxODFizszN MVS3OFUzPjd2
H2981 MkDLR5l1d3SxeHnjJGF{e2G7 MoPETWM2OD1yLkWg{txO MWO3O|MyODJ|
LOX NV7tZmo2S3m2b4TvfIlkKEG|c3H5 NWThfWxiUUN3ME2wMlA1OiEQvF2= NUDnfYN3Pzh3M{OzNS=>
C38 M1HuUGN6fG:2b4jpZ{BCe3OjeR?= Mo\rTWM2OD1yLkCxJO69VQ>? MonXPFA2PzJ7MR?=
EAC MULDfZRwfG:6aXOgRZN{[Xl? NFLpclQ4OiCq MlPpTWM2OD1yLkO1JO69VQ>? M{Dzb|g{PTByOEe=
SKVLB NH;GS3ZEgXSxdH;4bYMhSXO|YYm= NYDHOFMxUUN3ME21MlYh|ryP MoK5PFU4PjlzNB?=
AUC375 M2KwUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwMUGyJO69VQ>? MXq4OlQ5PjBy
A2780-C25 NHTHfJlEgXSxdH;4bYMhSXO|YYm= MkjDR5l1d3SxeHnjbZR6KGGpYXnud5Qhd3ijbHnwcIF1cW5vcnXzbZN1[W62IFGyO|gxNUN{NTD3bZRpKEmFNUCgc4YhOC5yNkOg{txO M3zKblg5OzF5NUW=
A2780-CP3 MVHDfZRwfG:6aXOgRZN{[Xl? NFzGO4lEgXSxdH;4bYNqfHliYXfhbY5{fCClaYPwcIF1cW5vcnXzbZN1[W62IFGyO|gxNUOSMzD3bZRpKEmFNUCgc4YhOC5yNU[g{txO MUC4PFMyPzV3
A2780-DX5 Ml3WR5l1d3SxeHnjJGF{e2G7 MXTDfZRwfG:6aXPpeJkh[WejaX7zeEBld3ixcoXibYNqdi2{ZYPpd5RidnRiQUK3PFAuTFh3IIfpeIghUUN3MDDv[kAxNjN3NzFOwG0> NEjUPIQ5QDNzN{W1
MXF7 Ml;rR5l1d3SxeHnjJGF{e2G7 NHy5Rm1CdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEB{\W6|aYTpeoUhVViINzD3bZRpKEmFNUCgc4YhOC5yMkig{txO MXW4PVYxPTV6
MXF7 MXzDfZRwfG:6aXOgRZN{[Xl? NYnJb5dCSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhdWm2b4jhcpRzd26nLYLld4l{fGGwdDDNXGY4KHerdHigTWM2OCCxZjCwMlAzQCEQvF2= NWr5UW5GQDl4MEW1PC=>
MXF7 Mn:2R5l1d3SxeHnjJGF{e2G7 NGTmVpRCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBld3ixcoXibYNqdi2{ZYPpd5RidnRiTWjGO{B4cXSqIFnDOVAhd2ZiMT6xO|Ih|ryP MnfnPFk3ODV3OB?=
WiDr M1rhS2N6fG:2b4jpZ{BCe3OjeR?= MXjBZ5Rqfmm2eTDh[4FqdnO2IIPlcpNqfGm4ZTDXbWRzKGOnbHyge4l1cCCLQ{WwJI9nKDBwMEWzJO69VQ>? NIHvUpA5QTZyNUW4
MCF M{TvRmZ2dmO2aX;uJGF{e2G7 NWm0UGc3WmW4ZYLzZYwhd2ZiUD3ndE1u\WSrYYTl[EBufWy2aXTyeYchemW|aYP0ZY5k\SCjc4Pld5Nm\CCjczDlcohidmOnbXXueEBqdiCleYTveI95cWOrdImgc4Yh[WS{aXHtfYNqdg>? MkT1PFk5PDF3MR?=
C6 NXP1fpVmS3m2b4TvfIlkKEG|c3H5 Moi5Nk42KG2pL33M NIj3bVQ4OiCq NX3Z[4h{TE2VTx?= NHvnS4tEgXSxdH;4bYNqfHliYXfhbY5{fCC{YYSgR|Yh[2WubIOgZZQhPTBidXevcWwhfG9iMj61JI1oN22O NYOwc4hMQDl6OE[wOC=>
C6 NX;ZTIo3TnWwY4Tpc44hSXO|YYm= M1LTOlIvPSCvZz;tUC=> MmjaOEBp NGDEe3NFVVOR NWnle3hbUW6qaXLpeIlwdiCxZjD0eYJ2dGmwIIDvcJlu\XKrenH0bY9v MoPLPFk5QDZyNB?=
C6 M2LVSmN6fG:2b4jpZ{BCe3OjeR?= NYPr[pNvOi53IH3nM41N NWHCdIVHPSCq NUfMWYllTE2VTx?= MmrnR5l1d3SxeHnjbZR6KGG|c3Xzd4VlKGG|IHPlcIwhemWuZXHz[S=> NUDNUmRjQDl6OE[wOC=>
SKVLB MWnDfZRwfG:6aXOgRZN{[Xl? NFHP[GM4OiCq MUfJR|UxRTZwNUSg{txO M1nyS|kxODN3MkC=
MCF7/VP16 M3PCTmN6fG:2b4jpZ{BCe3OjeR?= NYLDZXp{PTBizsznM41N MYK3NkBp NF7PR2dKSzVyPUG0MlIh|ryP MmDjPVAzOjd7Mh?=
CA755 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHZNVAh|ryP MY[2JIQ> M4P5emlEPTB;MD6wNVQh|ryP M{DCeVk2OjZ3N{C=
CHO NH7P[YNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTXNVAh|ryP Ml\iOkBl Ml;BTWM2OD1yLkC2JO69VQ>? NYLzcYJUQTV{NkW3NC=>
Panc02 NULEOWRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3ey[VExKM7:TR?= MVO2JIQ> M3XKd2lEPTB;MD6wOlUh|ryP NWjKfplwQTV{NkW3NC=>
PC14 M4CwV2N6fG:2b4jpZ{BCe3OjeR?= MVK0JIQ> Ml\BSG1UVw>? MWDJR|UxRTBwMkmg{txO M4Gxb|k5OjJ3NEK=
HOP62 NUXsbJdjS3m2b4TvfIlkKEG|c3H5 NF3oXpQ4OiCq MWHJR|UxRTBwMEC0JO69VQ>? MWm5PFc{PjZz
SF-295 NIfz[pBEgXSxdH;4bYMhSXO|YYm= Mn3NO|IhcA>? NF7ucW1KSzVyPUCuNFM2KM7:TR?= NHvObmU6QDd|Nk[x
MDA-MB-361 M{HNV2N6fG:2b4jpZ{BCe3OjeR?= M2ruSlEhcA>? M4XMV2ROW09? MXTDfZRwfG:6aXPpeJkh[WejaX7zeEBOTEFvTVKtN|YyKGW6cILld5NqdmdiTHHjXkB4cXSqIFnDOVAhd2ZiMD6wNVIh|ryP M2npNFExOzl3NEmw
MDA-MB-361 NULiWXNyS3m2b4TvfIlkKEG|c3H5 NH6yPFgyKGh? NF33bmlFVVOR M3uyfWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2GQTDNRkA{PjFiZYjwdoV{e2mwZzDjZZJjd3i7cHXweIll[XOnIIP0R3BIOiC5aYToJGlEPTBib3[gNE4xOThizszN NWHvSWpNOTB|OUW0PVA>
CCRF-SB MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWT1cpJFPCCm NFTEdI9FVVOR M3v5VmlEPTB;MD6wNUDPxE1? M3yzNlExPDFzNEe2
CHO-K1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moe0OEBl MknVSG1UVw>? NI\yeHNKSzVyPUCuOEDPxE1? MlTTNVA1OTF2N{[=
KB M1HSeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4D6SVQh\A>? M{LtNWROW09? NEXZW4VCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIRzfWdvcnXzbZN1[W62IFvCO2Qhf2m2aDDJR|UxKG:oIECuOlUh|ryP NUDUdlhsOTB2MUG0O|Y>
KB MlXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrDNod7PCCm MnvGSG1UVw>? NHT3XmNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIRzfWdvcnXzbZN1[W62IFvCR4FueHerdHigTWM2OCCxZjCwMlA3KM7:TR?= NX\HPFRvOTB2MUG0O|Y>
KB NWmySZZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvkOEBl NFHEbopFVVOR M1TKdGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4Sg[JJ2\y2{ZYPpd5RidnRiS1LNSHIhf2m2aDDJR|UxKG:oIECuOUDPxE1? M3;ROFExPDFzNEe2
KB M4rPOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\xOEBl NWKyXnFbTE2VTx?= MmWyRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDkdpVoNXKnc3nzeIFvfCCNQm[yNGMhf2m2aDDJR|UxKG:oIECuOEDPxE1? MU[xNFQyOTR5Nh?=
HTB-54 NELlWGVEgXSxdH;4bYMhSXO|YYm= MYCxNFAh|ryP NV\kR|M1UUN3ME2xMlEh|ryP NV\INHRZOTB2N{[4OlE>
MEL-AC M2nMXWN6fG:2b4jpZ{BCe3OjeR?= MV2xNFAh|ryP NV[1OGNvUUN3ME2xMlIh|ryP NVWyUJhVOTB2N{[4OlE>
DU145 M4PmN2N6fG:2b4jpZ{BCe3OjeR?= NV2yeo1WPzJiaB?= Mki5TWM2OD1yLkC1Nlgh|ryP MlOzNVA1Pzl{OEK=
K562R NUDNW4prS3m2b4TvfIlkKEG|c3H5 MlftO|IhcA>? MVLJR|UxRTBwMEG1OkDPxE1? MWixNFQ4QTJ6Mh?=
PACA-2 NET6[XBEgXSxdH;4bYMhSXO|YYm= NU\ZcYRXPiCm M1zlSGVFPTB;MD6wNFY{KM7:TR?= NFLxXXAyODR7OEKxOC=>
3Y1 M{fHemN6fG:2b4jpZ{BCe3OjeR?= M1nFeFczKGh? MWLHTVUxRTBwMECzPEDPxE1? NHT0OYwyODZ7MUexNC=>
P388 NWHneI1SS3m2b4TvfIlkKEG|c3H5 NGHlXXM4OiCq NFqzUHhIUTVyPUCuNFEzKM7:TR?= M375N|ExPjlzN{Gw
HMV-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4T4OWlEPTB;MD6yPEDPxE1? M4PUSVExPjl6NEO2
MKN-1 MmrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYi4RYpCUUN3ME2wMlY1KM7:TR?= MlW2NVA3QTh2M{[=
PC14 M2XMV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLLc3hwUUN3ME2xMlkh|ryP NX\1[oFiOTB4OUi0N|Y>
T24 MoLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fDcGlEPTB;MD62OEDPxE1? NFXMU|kyODZ7OESzOi=>
U937 MV7GeY5kfGmxbjDBd5NigQ>? Mnm1NlQhcA>? NYX4bo82TE2VTx?= MYrJcohq[mm2czDpcoNwenCxcnH0bY9vKG:oIGuzTH11cHmvaXTpcoUhf2m2aDDJR|UxKG:oIECuNUDPxE1? MUKxNFc5ODlzMR?=
H460pv8/eto Mm\GR5l1d3SxeHnjJGF{e2G7 MUixNFAh|ryP NH60cIg1QCCq MYTTZYxqdmV? NWPL[443UUN3ME2wMlAzKM7:TR?= MkTDNVA4QDB7MUO=
H460pv8 NIr5OWVEgXSxdH;4bYMhSXO|YYm= NEXyXlgyODBizszN MVq0PEBp Mnj1V4FtcW6n NHTOSG1KSzVyPUCuNFA1KM7:TR?= MX[xNFc5ODlzMx?=
MDA-231 M3j5fGN6fG:2b4jpZ{BCe3OjeR?= NG\ZcXYyODBizszN M1OwUlQ5KGh? MV;TZYxqdmV? MW\DfZRwfG:6aXPpeJkh[WejaX7zeEBOTEFvMkOxJINmdGxiKFXSMUxGT0[UKzzteZRidnRicEWzLUB4cXSqIFnDOVAhd2ZiMD6wNFYh|ryP MkPRNVA4QDB7MUO=
MDA-468 MVfDfZRwfG:6aXOgRZN{[Xl? NWjuNVhzOTByIN88US=> NYXuNVBpPDhiaB?= NVzLOmZtW2GuaX7l M4DmemN6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2GQT20Olgh[2WubDCoSXIuNCCjbYDsbYZq\WRiRVfGVkwhdXW2YX70JJA2Oylid3n0bEBKSzVyIH;mJFAvODB3IN88US=> Mn21NVA4QDB7MUO=
NCI-H226 NXPFNJZZS3m2b4TvfIlkKEG|c3H5 MXWxNFAh|ryP M4TjcVQ5KGh? NFH2dVFU[WyrbnW= NVzkSJdIS3m2b4TvfIlkcXS7IHHnZYlve3RiTlPJMWgzOjZiY3XscEApdXW2YX70JJA2Oylid3n0bEBKSzVyIH;mJFAvODB6IN88US=> NIfiT|QyODd6MEmxNy=>
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BT-20 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLZd4RKSzVyPUGuO|QxPjhizszN MUTTRW5ITVJ?
NCI-H28 M4r2PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVWyeHlnUUN3ME2xMlc1ODd6IN88US=> NGTyRnNUSU6JRWK=
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NCI-H889 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTHTWM2OD1zLkmzPFg3KM7:TR?= MlfPV2FPT0WU
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SW1088 NXfJc5J7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrwenZvUUN3ME2yMlA3QTNzIN88US=> NGj6c4ZUSU6JRWK=
NB6 M1uzbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LRUGlEPTB;Mj6xPFUh|ryP MnXCV2FPT0WU
KU-19-19 M1n3dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHlTWM2OD1{LkK2PVE4KM7:TR?= Mn\GV2FPT0WU
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EVSA-T NIjtS2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTJwM{CwPFkh|ryP NVz2SZhWW0GQR1XS
HCT-15 NXXFVGRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnFVnZxUUN3ME2yMlM2PDZ4IN88US=> MkToV2FPT0WU
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GMS-10 NHrRbHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;zSGlEPTB;Mj6zPVc{QCEQvF2= MWnTRW5ITVJ?
TGBC24TKB NVTwUmw1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LycmlEPTB;Mj60NVQzQSEQvF2= MmTGV2FPT0WU
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SK-N-DZ MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmiwTWM2OD1{LkW2OVkzKM7:TR?= Mn;hV2FPT0WU
SK-N-AS MlHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDzZ3dLUUN3ME2yMlc{ODF3IN88US=> M37mOnNCVkeHUh?=
T98G MlzyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHxTWM2OD1{LkiwOFAyKM7:TR?= NX7CV2FCW0GQR1XS
DMS-79 M3nTeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPmPZlKSzVyPUKuPVA6QDhizszN MmfNV2FPT0WU
SNU-475 NIW4WZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DVOWlEPTB;Mj65NlU4OiEQvF2= MVTTRW5ITVJ?
COLO-792 MmLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTNwMEK4O{DPxE1? M2jIWnNCVkeHUh?=
YAPC NVnHZZpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTNwM{K4N|Ih|ryP M{PiOXNCVkeHUh?=
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Mewo M33rS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PWZ2lEPTB;Mz60OlA5PiEQvF2= Mo[4V2FPT0WU
COLO-824 NXm1VndET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXMTWM2OD1|LkW3N|c5KM7:TR?= M4SyU3NCVkeHUh?=
SCC-9 NVrZdGRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HhZ2lEPTB;Mz65NVMxQSEQvF2= M1rhO3NCVkeHUh?=
CP50-MEL-B MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{T5fGlEPTB;Mz65PFcxOyEQvF2= M136NHNCVkeHUh?=
NCI-H345 M{HDdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\GVZE{UUN3ME20MlAyOTd2IN88US=> MlriV2FPT0WU
COR-L88 NX2wXo1KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTRwM{m1PEDPxE1? NXT6WFhNW0GQR1XS
RCM-1 M3LkSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PP[mlEPTB;ND60PVI4OiEQvF2= NUfvWnZ1W0GQR1XS
JVM-3 NEDoNo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7MTWM2OD12Lk[wOlE5KM7:TR?= M1ribHNCVkeHUh?=
ECC4 M4XiN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7aO202UUN3ME20Mlc3PTRzIN88US=> M1\GbXNCVkeHUh?=
MDA-MB-453 Mm[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\PZpRlUUN3ME20Mlg2OTN2IN88US=> M1jnWnNCVkeHUh?=
SK-N-FI NGPTZ3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIeyZmlKSzVyPUWuNlI5PzdizszN MXTTRW5ITVJ?
D-502MG MkXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTVwMkSyOlIh|ryP NYXJRZNzW0GQR1XS
NCI-H2227 M2HqR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moe4TWM2OD13LkO2NlMyKM7:TR?= NGHrSJRUSU6JRWK=
DMS-53 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTwTWM2OD14LkG3NVA3KM7:TR?= MkTXV2FPT0WU
LB771-HNC M4DDSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\oTWM2OD14LkS2PFA3KM7:TR?= MmKyV2FPT0WU
BB49-HNC M{f0fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;SdHpKSzVyPUeuOFE4QTFizszN NWjDXIJiW0GQR1XS
MDA-MB-415 NI\IbmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTdwNUezNFMh|ryP MVLTRW5ITVJ?
TALL-1 NIL6UodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTdwOU[4PEDPxE1? M1\IVXNCVkeHUh?=
HCC1395 MnG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRThwMUWxNlIh|ryP MV;TRW5ITVJ?
EFE-184 M2T6Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWW1c4pwUUN3ME24MlM4OjF4IN88US=> Mkf2V2FPT0WU
EC-GI-10 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIi5Sm5KSzVyPUiuOlg3QDZizszN NWLmT4REW0GQR1XS
TT NGjNOHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7nXpR2UUN3ME25MlA3QTZ4IN88US=> M3u5WnNCVkeHUh?=
U-2-OS NHqwOWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HGV2lEPTB;OT64NVM6OyEQvF2= M{WycnNCVkeHUh?=
SHP-77 NHjrfmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTuTWM2OD17LkmwNlkh|ryP MXnTRW5ITVJ?
HCC1143 M3XqeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TBRmlEPTB;MUCuOFc6PyEQvF2= MXnTRW5ITVJ?
A498 NXTjTVBHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnSPJF{UUN3ME2xPE4zQTd4IN88US=> NU\PTG5OW0GQR1XS
LS-513 NWjGfJpyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnP4TWM2OD1zOD62NFk{KM7:TR?= Mm\sV2FPT0WU
K052 NFOwNI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PscmlEPTB;MkGuOFQyQCEQvF2= MlH0V2FPT0WU
SiHa NUTKfG1GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXXTWM2OD1{Mz6zN|cyKM7:TR?= M4XlUHNCVkeHUh?=
RCC10RGB MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\oPYlpUUN3ME2zNE4xPjFzIN88US=> NXnRSGtRW0GQR1XS
NCI-SNU-16 Ml7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHpOmx{UUN3ME2zNU4yQDN4IN88US=> NV70WnN3W0GQR1XS
SNU-C1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HF[WlEPTB;M{KuOFE4PSEQvF2= NXv6T44zW0GQR1XS
C32 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3FTWM2OD1|Mj64O|Ih|ryP MXrTRW5ITVJ?
SW684 NVfkRowxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPCeIdKSzVyPUO0MlE2PjFizszN NUTxSYRDW0GQR1XS
SK-MEL-28 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\xfZE1UUN3ME2zOU42Ozd5IN88US=> MmKzV2FPT0WU
SK-MEL-1 M1TINGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3lNGZKSzVyPUO2Mlc2PDdizszN M3XOfHNCVkeHUh?=
NCI-H720 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvjN|lKSzVyPUSxMlk4OjZizszN NG\INZZUSU6JRWK=
P31-FUJ MofoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmf0TWM2OD12ND6zNlg1KM7:TR?= NIjCfnJUSU6JRWK=
NCI-H524 Moe5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTDTWM2OD12OD64NlQ5KM7:TR?= MnnXV2FPT0WU

多くの細胞株試験データを見る場合、クリックしてください

体内試験 In vivo, Doxorubicin in combination with adenoviral MnSOD (AdMnSOD) plus 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) has the greatest effect in decreasing the volumes of MB231 tumors and prolonging survival of mice. [1] Although its use is limited by the chronic and acute toxic side effects it produces, Doxorubicin is essential in treating breast and oesophageal carcinomas, solid tumours in childhood, osteosarcomas, Kaposi's sarcoma, soft tissue sarcomas, and Hodgkin and non-Hodgkin lymphomas. [2]

お薦めの試験操作(参考用のみ)

動物試験:[1]
+ 展開
  • 動物モデル: Female athymic nude mice injected s.c. with MB231 cells
  • 製剤: Dissolved in DMSO, and diluted in saline
  • 投薬量: 3 mg/kg/day
  • 投与方法: Delivered intratumorly
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 100 mg/mL (172.41 mM) warming
Water 20 mg/mL (34.48 mM)
Ethanol Insoluble

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 579.98
化学式

C27H29NO11.HCl

CAS No. 25316-40-9
保管
別名 NSC 123127

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03036904 Not yet recruiting Diffuse Large B-Cell Lymphoma|High Grade B-Cell Lymphoma Weill Medical College of Cornell University|Genentech, Inc.|Massachusetts General Hospital|M.D. Anderson Cancer Center February 6, 2017 Phase 1
NCT02659930 Recruiting Kaposi Sarcoma National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) January 4, 2016 Phase 1
NCT03042819 Not yet recruiting Soft Tissue Sarcoma University Health Network, Toronto|Karyopharm Therapeutics, Inc March 27, 2017 Phase 1
NCT03033914 Recruiting Hodgkin Lymphoma Memorial Sloan Kettering Cancer Center|Bristol-Myers Squibb|M.D. Anderson Cancer Center|City of Hope Medical Center January 25, 2017 Phase 1
NCT02957968 Recruiting Locally Advanced Breast Cancer|Invasive Adenocarcinoma of the Breast|Breast Cancer Stage II|Breast Cancer Stage III|Breast Cancer Stage IV Virginia Commonwealth University|Merck Sharp & Dohme Corp.|National Cancer Institute (NCI) January 24, 2017 Phase 2
NCT02377752 Active, not recruiting Neoplasm Eli Lilly and Company March 23, 2015 Phase 1

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    Why the IC50 of the compound varied over time in our measurement?

  • 回答:

    Sometimes the IC50 value might vary between different batch of compounds due to the slight differences in purity. If different IC50 was seen in the same batch of compound, the problem may lies in the process of dissolvement. Make sure that you see no particles and the solution is clear with your stock solution.

Topoisomeraseシグナル伝達経路

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Tags: Doxorubicin (Adriamycin) HClを買う | Doxorubicin (Adriamycin) HCl ic50 | Doxorubicin (Adriamycin) HCl供給者 | Doxorubicin (Adriamycin) HClを購入する | Doxorubicin (Adriamycin) HCl費用 | Doxorubicin (Adriamycin) HCl生産者 | オーダーDoxorubicin (Adriamycin) HCl | Doxorubicin (Adriamycin) HCl化学構造 | Doxorubicin (Adriamycin) HCl分子量 | Doxorubicin (Adriamycin) HCl代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID