Doxorubicin (Adriamycin) HCl

Licensed by Pfizer 製品コードS1208 別名:NSC 123127

Doxorubicin (Adriamycin) HCl化学構造

分子量(MW):579.98

Doxorubicin (Adriamycin) HClは一種の抗生物質試薬ですが、腫瘍細胞の中にDNA topoisomerase IIを抑制し、DNA損傷とアポトーシスを誘導します。

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JPY 19422.00
JPY 14940.00
JPY 34860.00
JPY 111220.00

文献中の使用例(32)

カスタマーフィードバック(8)

  • Enhancement of apoptotic response by addition of targeted agents lapatinib and sunitinib to doxorubicin in the same device reservoir at 24 hours. P values were determined using Student’s t test for all graphs.

    Sci Transl Med, 2015, 7(284): 284ra57 . Doxorubicin (Adriamycin) HCl purchased from Selleck.

    Cell viabilities with increasing concentrations of cisplatin (CP) and doxorubicin (DOXO) under normoxic and hypoxic condition for 48 hours were determined by MTT assay. IC50 values are presented as the means ?SDs (n=4) and * denotes p<0.05.

    Cancer Res 2014 74, 298-308. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • Cleavage of caspase-3, -9 and the expression of PARP were measured by western blot using b-actin as a loading control.

    Cell Cycle, 2017.. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    (C) & (D) Treatments with doxorubicin, cisplatin or AZD6244 further decreased the cell viability in RH30 cloned cells in which STAT3 or GP130 was knockdown by shRNA. (*P<.05, ** P <.01, *** P <.001).

    Curr Cancer Drug Targets, 2016, 16(7):631-8. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  •  

    Doxorubicin release of P(MAA-g-EG) and P(MAA-g-EG) containing nanoparticles in two-step pH conditions. Doxorubicinloaded P(MAA-g-EG) ,P(MAA-g-EG)-1.0NP ,P(MAA-g-EG)-2.5NP, and P(MAA-g-EG)-5.0NP crushed particles (75–150 um) were released in 1 PBS (pH 2.0) for 90 min. Then the pH was increased to 7.0 by adding 5N NaOH and release continued for 6 h.

    J Biomed Mater Res Part A 2012 10.1002/jbm.a.34064. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    Temporal uptake of free DOX or DOX-PCL63-b-PNVP90 micelles into K-562 (I) and DL (J) cells were studied by incubating in 24-well plates at a concentration of 50,000 cells per well. Representative images shown were obtained using a fluorescence microscope Eclipse 80i (Nikon, Japan) (Plan Fluor, 40X, NA 0.75 objective) equipped with blue and red filters for, Hoechst and Doxorubicin respectively (n = 3).

    PLoS One 2014 9, e94309. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • PLoS One 2013 8(1), e54595. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    CON+ -positive control (with FBS as chemoattractant); CON- - negative control (without chemoattractant); DOX -doxorubicin; WZ -WZ811; PF- PF-573228; * -significant difference compared to positive control: p<0.05; ** -significant difference compared to positive control: p<0.01; # -significant difference between combination and inhibitor only: p<0.05. Cancer cell invasion was analyzed using Transwell membranes assembled in 24-well plates and covered with a layer of Matrigel. COR-L23 cells were treated for 24 h with 50 nM DOX, 10 uM WZ811, 5 uM PF-573228 and combinations of inhibitors with 50 nM DOX. Similarly, RH460 cells were treated for 24 h with 1 uM DOX, 10 uM WZ811, 2.5 uM PF-573228 and combinations of inhibitors with 1 uM DOX. Applied doses were the ones that exerted the most pronounced synergistic effect on cytotoxicity level. After the incubation period, cells that invaded through matrigel and membranes were fixed in 4% paraformaldehyde-PBS and stained with Hoechst 33342 nuclear stain. Cells were visualized and counted under a fluorescent microscope at 10x magnification.

    2014 Dr Milica Pesic from Institute for Biological Research. Doxorubicin (Adriamycin) HCl purchased from Selleck.

製品安全説明書

Topoisomerase阻害剤の選択性比較

生物活性

製品説明 Doxorubicin (Adriamycin) HClは一種の抗生物質試薬ですが、腫瘍細胞の中にDNA topoisomerase IIを抑制し、DNA損傷とアポトーシスを誘導します。
ターゲット
Topo II [1]
(Tumor cells)
体外試験

Doxorubicin, an antibiotic anthracycline, is commonly considered to exert its anti-tumor activity at two fundamental levels, altering DNA and producing free radicals to trigger apoptosis of cancer cells through DNA damage. Doxorubicin can block the synthesis of DNA by intercalating into the DNA strand, and inhibits DNA topoisomerase II (TOP2). Doxorubicin is most effective when cells are rapidly proliferating and expressing high levels of TOP2. Additionally, Doxorubicin can trigger apoptosis by producing ceramide (which prompts apoptosis by activating p53 or other downstream pathways such as JNK), the degradation of Akt by serine threonine proteases, the mitochondrial release of cytochrome c, increased FasL (death receptor Fas/CD95 ligand) mRNA production, and a greater production of free radicals. [2] Pre-treatment with GSNO (nitrosoglutathione) suppresses the resistance in the doxorubicin-resistant breast cancer cell line MCF7/Dx, accompanied by enhanced protein glutathionylation and accumulation of doxorubicin in the nucleus. [3] Doxorubicin induced G2/M checkpoint arrest are attributed to elevated cyclin G2 (CycG2) expression and phospho-modification of proteins in the ataxia telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) signaling pathways. [5] Doxorubicin inhibits AMP-activated protein kinase (AMPK), resulting in SIRT1 dysfunction, p53 accumulation, and increased cell death in mouse embryonic fibroblasts (MEFs) and cardiomyocytes, which can be further sensitized by pre-inhibition of AMPK. [6] Doxorubicin elicits a marked heat shock response, and that either inhibition or silencing of heat shock proteins enhance the Doxorubicin apoptotic effect in neuroblastoma cells. Nanomolar Doxorubicin treatment of neuroblastoma cells causes dose-dependent over-ubiquitination of a specific set of proteins in the absence of measurable inhibition of proteasome, and loss of activity of ubiquitinated enzymes such as lactate dehydrogenase and α-enolase, the protein ubiquination patterns of which is similar to those with proteasome inhibitor Bortezomib, indicating that Doxorubicin may also exert its effect by damaging proteins. [8]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
L1210 MUXGeY5kfGmxbjDBd5NigQ>? NX;lNmE1UW6qaXLpeIlwdiCxZjDSUmEhe3mwdHjld4l{KHerdHigSWQ2OCCxZjCwMlU5KM7:TR?= MXm0PVA2OzZ?
Yoshida sarcoma M{e3UmZ2dmO2aX;uJGF{e2G7 NWHYc2c1UW6qaXLpeIlwdiCxZjDbN2heXGSUIHnuZ49zeG:{YYTpc44hf2m2aDDJR|UxKG:oIECuNFIh|ryP NF7qUIEyOzJ{OUi2
CHO MojnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4f3fmlEPTB;MD6wOkDPxE1? MWmxN|U1PzVy
8226 MlL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHiTWM2OD1yLkCzN{DPxE1? MmPwNVQ1Pzd|MB?=
8226/ADR MnraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwNU[g{txO NY\2eFN[OTR2N{ezNC=>
MCF7/ADR M3PocWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DY[GlEPTB;Mz6xJO69VQ>? NE\EbWUyPDR5N{Ow
H69 NXzlNXBGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnGV4pHUUN3ME2wMlg4KM7:TR?= M1r0[FE1Pzl3OEW=
N417 NGXpZpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rYSWlEPTB;MD6yN{DPxE1? NYTGZ|dKOTR5OUW4OS=>
H9 NXvOO3VFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnKZZpxUW6qaXLpeIlwdiCxZjDIPUBk\WyuczDjbJJwdmmlYXzsfUBqdm[nY4Tl[EB4cXSqIITo[UBJUVZvMTCoTFkwUUmLQjmge4l1cCCLREWwJI9nKDBwMEGg{txO M{K4TVE2PDh4OEG=
T-C8166 NGf3VWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjjWJVKTDVyPUCuNFEh|ryP MWqxOVQ5Pjhz
T-H9 NXrB[HR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1iwSmlFPTB;MD6wNUDPxE1? M4C4e|E2PDh4OEG=
T-MT4 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXy0eGk2UUR3ME2wMlAyKM7:TR?= M1v4U|E2PDh4OEG=
SKMEL-5 M3TOOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\LZWVFPTB;Mz6yJO69VQ>? M3jPblE3OTN5NUO=
MLM NEn0NY5EgXSxdH;4bYMhSXO|YYm= NXnLe3ZlTUR3ME2wMlE{KM7:TR?= MnPnNVg4PTN3MB?=
KBM-3 NFf5SlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHHepFxUUN3ME2wMlAzPiEQvF2= NG[xXWcyQTl3OEe3
HT-29 MkLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHXNWtVOC5yMTFOwIc> MXe0PEBp MmfpRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdIm= MmiyNlc4QDR2OR?=
EMT6 NHXveFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWiwMlUh|ryP NVHSOYRlOSCq M{DJOWlvcGmkaYTpc44hd2ZicILvcIln\XKjdHnvckBjgSCvZXHzeZJqdmdiZn;yJJN2en[rdnnu[{BnemGldHnvcpMhf2m2aDDFSFUxKG:oIECuNFAxOSEQvF2= MXK3OFUzPjd2
H2981 MUDDfZRwfG:6aXOgRZN{[Xl? NVnGdYhmUUN3ME2wMlUh|ryP NYS1VZN3Pzd|MUCyNy=>
LOX NYTDSWN2S3m2b4TvfIlkKEG|c3H5 M4foVGlEPTB;MD6wOFIh|ryP NV74Z5N5Pzh3M{OzNS=>
C38 MnXUR5l1d3SxeHnjJGF{e2G7 M2jUTGlEPTB;MD6wNUDPxE1? MVm4NFU4Ojlz
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AUC375 M4LVUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMUGyJO69VQ>? MYm4OlQ5PjBy
A2780-C25 NWjGZlBrS3m2b4TvfIlkKEG|c3H5 NFrVUoZEgXSxdH;4bYNqfHliYXfhbY5{fCCxeHHsbZBt[XSrbj3y[ZNqe3SjboSgRVI4QDBvQ{K1JJdqfGhiSVO1NEBw\iByLkC2N{DPxE1? MkmxPFg{OTd3NR?=
A2780-CP3 NIPKVpJEgXSxdH;4bYMhSXO|YYm= MWrDfZRwfG:6aXPpeJkh[WejaX7zeEBkcXOybHH0bY4uemW|aYP0ZY51KEF{N{iwMWNROyC5aYToJGlEPTBib3[gNE4xPTZizszN NY\m[INDQDh|MUe1OS=>
A2780-DX5 MVvDfZRwfG:6aXOgRZN{[Xl? Mn7mR5l1d3SxeHnjbZR6KGGpYXnud5Qh\G:6b4L1ZolkcW5vcnXzbZN1[W62IFGyO|gxNUS[NTD3bZRpKEmFNUCgc4YhOC5|NUeg{txO M{LkeVg5OzF5NUW=
MXF7 NFe1eXREgXSxdH;4bYMhSXO|YYm= NXfaWHFCSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5Qhe2Wwc3n0bZZmKE2[Rkege4l1cCCLQ{WwJI9nKDBwMEK4JO69VQ>? MX24PVYxPTV6
MXF7 MXvDfZRwfG:6aXOgRZN{[Xl? M{\E[mFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JI1qfG:6YX70do9v\S2{ZYPpd5RidnRiTWjGO{B4cXSqIFnDOVAhd2ZiMD6wNlgh|ryP NE\rXFA5QTZyNUW4
MXF7 NY\KUVQ3S3m2b4TvfIlkKEG|c3H5 MWfBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDkc5hwenWkaXPpck1z\XOrc4ThcpQhVViINzD3bZRpKEmFNUCgc4YhOS5zN{Kg{txO MmfmPFk3ODV3OB?=
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MCF NGjKfYRHfW6ldHnvckBCe3OjeR?= MorFVoV3\XK|YXygc4YhWC2pcD3t[YRq[XSnZDDteYx1cWS{dXegdoV{cXO2YX7j[UBie3Onc4Pl[EBieyCnbnjhcoNmdWWwdDDpckBkgXSxdH;4bYNqfHlib3[gZYRzcWGveXPpci=> NXjpPWZjQDl6NEG1NS=>
C6 MXvDfZRwfG:6aXOgRZN{[Xl? MmPkNk42KG2pL33M M1TZT|czKGh? M1XyPWROW09? MkKyR5l1d3SxeHnjbZR6KGGpYXnud5QhemG2IFO2JINmdGy|IHH0JFUxKHWpL33MJJRwKDJwNTDt[{9uVA>? NGHEdoM5QTh6NkC0
C6 NGezXmNHfW6ldHnvckBCe3OjeR?= NGC1SlMzNjVibXevcWw> M3Lwe|QhcA>? NYTKdFhmTE2VTx?= MlXPTY5pcWKrdHnvckBw\iC2dXL1cIlvKHCxbInt[ZJqgmG2aX;u M1jHW|g6QDh4MES=
C6 NVX6RpZGS3m2b4TvfIlkKEG|c3H5 NFXQV44zNjVibXevcWw> Mmr2OUBp MWHEUXNQ NFS1d3REgXSxdH;4bYNqfHliYYPz[ZN{\WRiYYOgZ4VtdCC{ZXzlZZNm NFvhWFU5QTh6NkC0
SKVLB MknJR5l1d3SxeHnjJGF{e2G7 NWLoRVd{PzJiaB?= NHfTOJRKSzVyPU[uOVQh|ryP M1HYfFkxODN3MkC=
MCF7/VP16 MX7DfZRwfG:6aXOgRZN{[Xl? M{D4dFUxKM7:Zz;tUC=> MVy3NkBp MX;JR|UxRTF2LkKg{txO MnG4PVAzOjd7Mh?=
CA755 M4rKWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVu2[49vOTBizszN MUC2JIQ> NF3CWHRKSzVyPUCuNFE1KM7:TR?= NVjJOotYQTV{NkW3NC=>
CHO MlS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfifVIyOCEQvF2= NV\Kfpp{PiCm M4r4[WlEPTB;MD6wOkDPxE1? M3HH[lk2OjZ3N{C=
Panc02 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\LNFRkOTBizszN M{jHPVYh\A>? NXjPe5RnUUN3ME2wMlA3PSEQvF2= NFrDNIY6PTJ4NUew
PC14 MUPDfZRwfG:6aXOgRZN{[Xl? MUO0JIQ> NEHsbJFFVVOR M4jJdGlEPTB;MD6yPUDPxE1? M3vL[Vk5OjJ3NEK=
HOP62 NHj0fnNEgXSxdH;4bYMhSXO|YYm= MUC3NkBp MYjJR|UxRTBwMEC0JO69VQ>? NU\yXXgzQTh5M{[2NS=>
SF-295 NV7zVnQ6S3m2b4TvfIlkKEG|c3H5 MYi3NkBp MnPsTWM2OD1yLkCzOUDPxE1? MnLrPVg4OzZ4MR?=
MDA-MB-361 MVrDfZRwfG:6aXOgRZN{[Xl? MoO5NUBp NFe1b25FVVOR M1SzPGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2GQT3NRk0{PjFiZYjwdoV{e2mwZzDMZYNbKHerdHigTWM2OCCxZjCwMlAyOiEQvF2= NYXEe|BXOTB|OUW0PVA>
MDA-MB-361 M1;xS2N6fG:2b4jpZ{BCe3OjeR?= MonnNUBp NGXqWJVFVVOR NULjTHlSS3m2b4TvfIlkcXS7IHHnZYlve3RiTVTBJG1DKDN4MTDlfJBz\XO|aX7nJINiemKxeInw[ZB1cWSjc3Wgd5REWEd{IIfpeIghUUN3MDDv[kAxNjBzODFOwG0> M1fSTFExOzl3NEmw
CCRF-SB MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVW0JIQ> NIfFfIpFVVOR M4HaNmlEPTB;MD6wNUDPxE1? NEK3UnYyODRzMUS3Oi=>
CHO-K1 NVzyT5NUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jLO|Qh\A>? M1fRRWROW09? MmXJTWM2OD1yLkSg{txO NVTOcGk{OTB2MUG0O|Y>
KB NYjBRmQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH6zVI41KGR? MVfEUXNQ NEHhTGtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIRzfWdvcnXzbZN1[W62IFvCO2Qhf2m2aDDJR|UxKG:oIECuOlUh|ryP MoLBNVA1OTF2N{[=
KB M4jvO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHDelI1KGR? NEPGdXNFVVOR NY\YTmFXSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBlenWpLYLld4l{fGGwdDDLRmNidXC5aYToJGlEPTBib3[gNE4xPiEQvF2= MkDtNVA1OTF2N{[=
KB MoHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\qcIs1KGR? MV3EUXNQ NV;ROJVRSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBlenWpLYLld4l{fGGwdDDLRm1FWiC5aYToJGlEPTBib3[gNE42KM7:TR?= NU\3OlBmOTB2MUG0O|Y>
KB NFTOfohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{L4OVQh\A>? M2ixW2ROW09? NFrlVnFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIRzfWdvcnXzbZN1[W62IFvCWlIxSyC5aYToJGlEPTBib3[gNE41KM7:TR?= NF;CbIMyODRzMUS3Oi=>
HTB-54 NFnZTnpEgXSxdH;4bYMhSXO|YYm= MUWxNFAh|ryP NFvrXIZKSzVyPUGuNUDPxE1? NVzTcZZFOTB2N{[4OlE>
MEL-AC M{\EbWN6fG:2b4jpZ{BCe3OjeR?= MXOxNFAh|ryP NX3y[XB6UUN3ME2xMlIh|ryP NI\vd3cyODR5Nki2NS=>
DU145 M3XxOWN6fG:2b4jpZ{BCe3OjeR?= M2ezcVczKGh? NV[5cYVZUUN3ME2wMlA2OjhizszN MlXuNVA1Pzl{OEK=
K562R MnPyR5l1d3SxeHnjJGF{e2G7 MX63NkBp MlruTWM2OD1yLkCxOVYh|ryP MkHqNVA1Pzl{OEK=
PACA-2 M2DJZmN6fG:2b4jpZ{BCe3OjeR?= MmXhOkBl NGe5c4ZGTDVyPUCuNFA3OyEQvF2= NXzYUZNHOTB2OUiyNVQ>
3Y1 NEPqT4lEgXSxdH;4bYMhSXO|YYm= MlHBO|IhcA>? M{CwN2dKPTB;MD6wNFM5KM7:TR?= Mk\5NVA3QTF5MUC=
P388 M{DCVWN6fG:2b4jpZ{BCe3OjeR?= NX\Ib3MxPzJiaB?= NFi5XIdIUTVyPUCuNFEzKM7:TR?= NUDxVJQ{OTB4OUG3NVA>
HMV-1 NV22TlZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjOUnFKSzVyPUCuNlgh|ryP NGjKOnEyODZ7OESzOi=>
MKN-1 NInYRllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwNkSg{txO MoD3NVA3QTh2M{[=
PC14 NYTmZY9YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXOWnFzUUN3ME2xMlkh|ryP MWWxNFY6QDR|Nh?=
T24 NYjOWmFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVuxcpZ7UUN3ME2wMlY1KM7:TR?= MWGxNFY6QDR|Nh?=
U937 MnTaSpVv[3Srb36gRZN{[Xl? MWqyOEBp NUPZc3VsTE2VTx?= MoXaTY5pcWKrdIOgbY5kd3Kyb4LheIlwdiCxZjDbN2hefGi7bXnkbY5mKHerdHigTWM2OCCxZjCwMlEh|ryP M1H5ZVExPzhyOUGx
H460pv8/eto Mm[4R5l1d3SxeHnjJGF{e2G7 NYXG[3YyOTByIN88US=> MYC0PEBp NHXpenBU[WyrbnW= MXzJR|UxRTBwMEKg{txO Mlz6NVA4QDB7MUO=
H460pv8 MWDDfZRwfG:6aXOgRZN{[Xl? MkW1NVAxKM7:TR?= MV:0PEBp MlLCV4FtcW6n M4HNemlEPTB;MD6wNFQh|ryP MnmyNVA4QDB7MUO=
MDA-231 NEPwNWhEgXSxdH;4bYMhSXO|YYm= M2ny[VExOCEQvF2= NY\TPVVJPDhiaB?= M3H3cHNidGmwZR?= MUXDfZRwfG:6aXPpeJkh[WejaX7zeEBOTEFvMkOxJINmdGxiKFXSMUxGT0[UKzzteZRidnRicEWzLUB4cXSqIFnDOVAhd2ZiMD6wNFYh|ryP NXz4PHlROTB5OEC5NVM>
MDA-468 Mnn4R5l1d3SxeHnjJGF{e2G7 MWixNFAh|ryP NFjoXIg1QCCq MWDTZYxqdmV? MnjvR5l1d3SxeHnjbZR6KGGpYXnud5QhVUSDLUS2PEBk\WyuIDjFVk0tKGGvcHzp[olm\CCHR1\SMEBufXSjboSgdFU{MSC5aYToJGlEPTBib3[gNE4xODVizszN NIW2O5QyODd6MEmxNy=>
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EHEB NIDRW3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmT5TWM2OD1zMUKuOVkhdk1? MXnTRW5ITVJ?
TE-10 M1;YOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3nTWM2OD1zMUKuOlghdk1? MlLFV2FPT0WU
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WSU-NHL MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXYPW5KSzVyPUG1OE42QCCwTR?= M1W3TXNCVkeHUh?=
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多くの細胞株試験データを見る場合、クリックしてください

体内試験 In vivo, Doxorubicin in combination with adenoviral MnSOD (AdMnSOD) plus 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) has the greatest effect in decreasing the volumes of MB231 tumors and prolonging survival of mice. [1] Although its use is limited by the chronic and acute toxic side effects it produces, Doxorubicin is essential in treating breast and oesophageal carcinomas, solid tumours in childhood, osteosarcomas, Kaposi's sarcoma, soft tissue sarcomas, and Hodgkin and non-Hodgkin lymphomas. [2]

お薦めの試験操作(参考用のみ)

動物試験:[1]
+ 展開
  • 動物モデル: Female athymic nude mice injected s.c. with MB231 cells
  • 製剤: Dissolved in DMSO, and diluted in saline
  • 投薬量: 3 mg/kg/day
  • 投与方法: Delivered intratumorly
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 100 mg/mL (172.41 mM) warming
Water 20 mg/mL (34.48 mM)
Ethanol Insoluble

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 579.98
化学式

C27H29NO11.HCl

CAS No. 25316-40-9
保管
別名 NSC 123127

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03036904 Not yet recruiting Diffuse Large B-Cell Lymphoma|High Grade B-Cell Lymphoma Weill Medical College of Cornell University|Genentech, Inc.|Massachusetts General Hospital|M.D. Anderson Cancer Center February 6, 2017 Phase 1
NCT02659930 Recruiting Kaposi Sarcoma National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) January 4, 2016 Phase 1
NCT03042819 Not yet recruiting Soft Tissue Sarcoma University Health Network, Toronto|Karyopharm Therapeutics, Inc March 27, 2017 Phase 1
NCT03033914 Recruiting Hodgkin Lymphoma Memorial Sloan Kettering Cancer Center|Bristol-Myers Squibb|M.D. Anderson Cancer Center|City of Hope Medical Center January 25, 2017 Phase 1
NCT02957968 Recruiting Locally Advanced Breast Cancer|Invasive Adenocarcinoma of the Breast|Breast Cancer Stage II|Breast Cancer Stage III|Breast Cancer Stage IV Virginia Commonwealth University|Merck Sharp & Dohme Corp.|National Cancer Institute (NCI) January 24, 2017 Phase 2
NCT02377752 Active, not recruiting Neoplasm Eli Lilly and Company March 23, 2015 Phase 1

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    Why the IC50 of the compound varied over time in our measurement?

  • 回答:

    Sometimes the IC50 value might vary between different batch of compounds due to the slight differences in purity. If different IC50 was seen in the same batch of compound, the problem may lies in the process of dissolvement. Make sure that you see no particles and the solution is clear with your stock solution.

Topoisomerase信号経路図

相関Topoisomerase製品

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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID