Doxorubicin (Adriamycin) HCl

Licensed by Pfizer 製品コードS1208 別名:NSC 123127

Doxorubicin (Adriamycin) HCl化学構造

分子量(MW):579.98

Doxorubicin (Adriamycin) HClは一種の抗生物質試薬ですが、腫瘍細胞の中にDNA topoisomerase IIを抑制し、DNA損傷とアポトーシスを誘導します。

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JPY 12958.92 あり
JPY 30237.48 あり
JPY 96471.96 あり

文献中の引用(31)

カスタマーフィードバック(8)

  • Enhancement of apoptotic response by addition of targeted agents lapatinib and sunitinib to doxorubicin in the same device reservoir at 24 hours. P values were determined using Student’s t test for all graphs.

    Sci Transl Med, 2015, 7(284): 284ra57 . Doxorubicin (Adriamycin) HCl purchased from Selleck.

    Cell viabilities with increasing concentrations of cisplatin (CP) and doxorubicin (DOXO) under normoxic and hypoxic condition for 48 hours were determined by MTT assay. IC50 values are presented as the means ?SDs (n=4) and * denotes p<0.05.

    Cancer Res 2014 74, 298-308. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • Cleavage of caspase-3, -9 and the expression of PARP were measured by western blot using b-actin as a loading control.

    Cell Cycle, 2017.. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    (C) & (D) Treatments with doxorubicin, cisplatin or AZD6244 further decreased the cell viability in RH30 cloned cells in which STAT3 or GP130 was knockdown by shRNA. (*P<.05, ** P <.01, *** P <.001).

    Curr Cancer Drug Targets, 2016, 16(7):631-8. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  •  

    Doxorubicin release of P(MAA-g-EG) and P(MAA-g-EG) containing nanoparticles in two-step pH conditions. Doxorubicinloaded P(MAA-g-EG) ,P(MAA-g-EG)-1.0NP ,P(MAA-g-EG)-2.5NP, and P(MAA-g-EG)-5.0NP crushed particles (75–150 um) were released in 1 PBS (pH 2.0) for 90 min. Then the pH was increased to 7.0 by adding 5N NaOH and release continued for 6 h.

    J Biomed Mater Res Part A 2012 10.1002/jbm.a.34064. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    Temporal uptake of free DOX or DOX-PCL63-b-PNVP90 micelles into K-562 (I) and DL (J) cells were studied by incubating in 24-well plates at a concentration of 50,000 cells per well. Representative images shown were obtained using a fluorescence microscope Eclipse 80i (Nikon, Japan) (Plan Fluor, 40X, NA 0.75 objective) equipped with blue and red filters for, Hoechst and Doxorubicin respectively (n = 3).

    PLoS One 2014 9, e94309. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • PLoS One 2013 8(1), e54595. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    CON+ -positive control (with FBS as chemoattractant); CON- - negative control (without chemoattractant); DOX -doxorubicin; WZ -WZ811; PF- PF-573228; * -significant difference compared to positive control: p<0.05; ** -significant difference compared to positive control: p<0.01; # -significant difference between combination and inhibitor only: p<0.05. Cancer cell invasion was analyzed using Transwell membranes assembled in 24-well plates and covered with a layer of Matrigel. COR-L23 cells were treated for 24 h with 50 nM DOX, 10 uM WZ811, 5 uM PF-573228 and combinations of inhibitors with 50 nM DOX. Similarly, RH460 cells were treated for 24 h with 1 uM DOX, 10 uM WZ811, 2.5 uM PF-573228 and combinations of inhibitors with 1 uM DOX. Applied doses were the ones that exerted the most pronounced synergistic effect on cytotoxicity level. After the incubation period, cells that invaded through matrigel and membranes were fixed in 4% paraformaldehyde-PBS and stained with Hoechst 33342 nuclear stain. Cells were visualized and counted under a fluorescent microscope at 10x magnification.

    2014 Dr Milica Pesic from Institute for Biological Research. Doxorubicin (Adriamycin) HCl purchased from Selleck.

製品安全説明書

Topoisomerase阻害剤の選択性比較

生物活性

製品説明 Doxorubicin (Adriamycin) HClは一種の抗生物質試薬ですが、腫瘍細胞の中にDNA topoisomerase IIを抑制し、DNA損傷とアポトーシスを誘導します。
ターゲット
Topo II [1]
(Tumor cells)
体外試験

Doxorubicin, an antibiotic anthracycline, is commonly considered to exert its anti-tumor activity at two fundamental levels, altering DNA and producing free radicals to trigger apoptosis of cancer cells through DNA damage. Doxorubicin can block the synthesis of DNA by intercalating into the DNA strand, and inhibits DNA topoisomerase II (TOP2). Doxorubicin is most effective when cells are rapidly proliferating and expressing high levels of TOP2. Additionally, Doxorubicin can trigger apoptosis by producing ceramide (which prompts apoptosis by activating p53 or other downstream pathways such as JNK), the degradation of Akt by serine threonine proteases, the mitochondrial release of cytochrome c, increased FasL (death receptor Fas/CD95 ligand) mRNA production, and a greater production of free radicals. [2] Pre-treatment with GSNO (nitrosoglutathione) suppresses the resistance in the doxorubicin-resistant breast cancer cell line MCF7/Dx, accompanied by enhanced protein glutathionylation and accumulation of doxorubicin in the nucleus. [3] Doxorubicin induced G2/M checkpoint arrest are attributed to elevated cyclin G2 (CycG2) expression and phospho-modification of proteins in the ataxia telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) signaling pathways. [5] Doxorubicin inhibits AMP-activated protein kinase (AMPK), resulting in SIRT1 dysfunction, p53 accumulation, and increased cell death in mouse embryonic fibroblasts (MEFs) and cardiomyocytes, which can be further sensitized by pre-inhibition of AMPK. [6] Doxorubicin elicits a marked heat shock response, and that either inhibition or silencing of heat shock proteins enhance the Doxorubicin apoptotic effect in neuroblastoma cells. Nanomolar Doxorubicin treatment of neuroblastoma cells causes dose-dependent over-ubiquitination of a specific set of proteins in the absence of measurable inhibition of proteasome, and loss of activity of ubiquitinated enzymes such as lactate dehydrogenase and α-enolase, the protein ubiquination patterns of which is similar to those with proteasome inhibitor Bortezomib, indicating that Doxorubicin may also exert its effect by damaging proteins. [8]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
L1210 NX7RUpp6TnWwY4Tpc44hSXO|YYm= MlTSTY5pcWKrdHnvckBw\iCUTlGgd5lvfGinc3nzJJdqfGhiRVS1NEBw\iByLkW4JO69VQ>? NFm5fnI1QTB3M{[=
Yoshida sarcoma NHvQ[JNHfW6ldHnvckBCe3OjeR?= NXLScJl[UW6qaXLpeIlwdiCxZjDbN2heXGSUIHnuZ49zeG:{YYTpc44hf2m2aDDJR|UxKG:oIECuNFIh|ryP NEfxbnMyOzJ{OUi2
CHO MlTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXWyV|Z4UUN3ME2wMlA3KM7:TR?= M2X4TlE{PTR5NUC=
8226 MnzwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwMEOzJO69VQ>? MkHzNVQ1Pzd|MB?=
8226/ADR MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33jcWlEPTB;MD61OkDPxE1? MkHiNVQ1Pzd|MB?=
MCF7/ADR M{G0UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvyRoRKSzVyPUOuNUDPxE1? NI[3c3oyPDR5N{Ow
H69 Ml;QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLuU2ZjUUN3ME2wMlg4KM7:TR?= NX3RNWlGOTR5OUW4OS=>
N417 NUDhS2NST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnLU2djUUN3ME2wMlI{KM7:TR?= NWfRRnc2OTR5OUW4OS=>
H9 MkWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\JTY5pcWKrdHnvckBw\iCKOTDj[YxteyClaILvcolk[WyueTDpcoZm[3SnZDD3bZRpKHSqZTDITXYuOSBqSEmvTWlKSilid3n0bEBKTDVyIH;mJFAvODFizszN MV[xOVQ5Pjhz
T-C8166 NVj1SHIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETRbWxKTDVyPUCuNFEh|ryP MmnCNVU1QDZ6MR?=
T-H9 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\pc2lFPTB;MD6wNUDPxE1? NXjKUppFOTV2OE[4NS=>
T-MT4 NVfhRoNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfHTWQ2OD1yLkCxJO69VQ>? MnS0NVU1QDZ6MR?=
SKMEL-5 M3HPTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTFSFUxRTNwMjFOwG0> NFnsbZkyPjF|N{Wz
MLM M2HGd2N6fG:2b4jpZ{BCe3OjeR?= NUjNfGk3TUR3ME2wMlE{KM7:TR?= M3W4SVE5PzV|NUC=
KBM-3 Mn\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlG4TWM2OD1yLkCyOkDPxE1? M1\a[VE6QTV6N{e=
HT-29 NETlS21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnCNE4xOSEQvHe= NX;EfoNVPDhiaB?= M3\vcGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5 NI\VTVUzPzd6NES5
EMT6 MmWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXWwMlUh|ryP MUexJIg> NX65[ZZ6UW6qaXLpeIlwdiCxZjDwdo9tcW[ncnH0bY9vKGK7IH3lZZN2emmwZzDmc5Ihe3W{dnn2bY5oKG[{YXP0bY9veyC5aYToJGVFPTBib3[gNE4xODBzIN88US=> MlHsO|Q2OjZ5NB?=
H2981 M2j3Z2N6fG:2b4jpZ{BCe3OjeR?= NGm5SnpKSzVyPUCuOUDPxE1? NUXiOXdEPzd|MUCyNy=>
LOX NX7RVYZ4S3m2b4TvfIlkKEG|c3H5 NHnrTVFKSzVyPUCuNFQzKM7:TR?= Mmr0O|g2OzN|MR?=
C38 NXnJZ49tS3m2b4TvfIlkKEG|c3H5 MnPMTWM2OD1yLkCxJO69VQ>? MVG4NFU4Ojlz
EAC MoPBR5l1d3SxeHnjJGF{e2G7 MVu3NkBp M4nwN2lEPTB;MD6zOUDPxE1? NYmyfnhUQDN3MEC4Oy=>
SKVLB MWfDfZRwfG:6aXOgRZN{[Xl? MlTjTWM2OD13Lk[g{txO NV3TT29UQDV5NkmxOC=>
AUC375 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwMUGyJO69VQ>? NX7X[oRRQDZ2OE[wNC=>
A2780-C25 MmfNR5l1d3SxeHnjJGF{e2G7 M1;yUWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG:6YXzpdIxifGmwLYLld4l{fGGwdDDBNlc5OC2FMkWge4l1cCCLQ{WwJI9nKDBwME[zJO69VQ>? NGDWSI85QDNzN{W1
A2780-CP3 MoLBR5l1d3SxeHnjJGF{e2G7 M{\TZmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGOrc4DsZZRqdi2{ZYPpd5RidnRiQUK3PFAuS1B|IIfpeIghUUN3MDDv[kAxNjB3NjFOwG0> Mn7vPFg{OTd3NR?=
A2780-DX5 NYnsVYtoS3m2b4TvfIlkKEG|c3H5 NWW0dG4xS3m2b4TvfIlkcXS7IHHnZYlve3RiZH;4c5J2[mmlaX6tdoV{cXO2YX70JGEzPzhyLVTYOUB4cXSqIFnDOVAhd2ZiMD6zOVch|ryP NGTmeGk5QDNzN{W1
MXF7 NVHDWWZOS3m2b4TvfIlkKEG|c3H5 Ml\MRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4Sgd4Vve2m2aY\lJG1ZTjdid3n0bEBKSzVyIH;mJFAvODJ6IN88US=> NEfENHg5QTZyNUW4
MXF7 MWrDfZRwfG:6aXOgRZN{[Xl? MWfBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDtbZRwgGGwdILvcoUuemW|aYP0ZY51KE2[Rkege4l1cCCLQ{WwJI9nKDBwMEK4JO69VQ>? MnPSPFk3ODV3OB?=
MXF7 NGK0bm1EgXSxdH;4bYMhSXO|YYm= NHjhU2NCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBld3ixcoXibYNqdi2{ZYPpd5RidnRiTWjGO{B4cXSqIFnDOVAhd2ZiMT6xO|Ih|ryP Mo\nPFk3ODV3OB?=
WiDr Mnv4R5l1d3SxeHnjJGF{e2G7 MUfBZ5Rqfmm2eTDh[4FqdnO2IIPlcpNqfGm4ZTDXbWRzKGOnbHyge4l1cCCLQ{WwJI9nKDBwMEWzJO69VQ>? MmK0PFk3ODV3OB?=
MCF NE\6fo9HfW6ldHnvckBCe3OjeR?= M{OzdnJmfmW{c3HsJI9nKFBvZ4CtcYVlcWG2ZXSgcZVtfGmmcoXnJJJme2m|dHHuZ4Uh[XO|ZYPz[YQh[XNiZX7oZY5k\W2nboSgbY4h[3m2b4TvfIlkcXS7IH;mJIFlemmjbYnjbY4> NXPaTohvQDl6NEG1NS=>
C6 NX60OpllS3m2b4TvfIlkKEG|c3H5 NWP0[Yc2Oi53IH3nM41N MVS3NkBp NFHOUmpFVVOR MYfDfZRwfG:6aXPpeJkh[WejaX7zeEBz[XRiQ{[gZ4VtdHNiYYSgOVAhfWdxbVygeI8hOi53IH3nM41N M2DFR|g6QDh4MES=
C6 NFuwc3lHfW6ldHnvckBCe3OjeR?= M1\qZlIvPSCvZz;tUC=> M3\LR|QhcA>? M{XRUGROW09? MYjJcohq[mm2aX;uJI9nKHS3YoXsbY4heG:ueX3ldol7[XSrb36= NIPU[mY5QTh6NkC0
C6 NWPOVWFqS3m2b4TvfIlkKEG|c3H5 NF21THMzNjVibXevcWw> MUS1JIg> NGrQdZVFVVOR MWrDfZRwfG:6aXPpeJkh[XO|ZYPz[YQh[XNiY3XscEBz\WynYYPl NXnjRVhxQDl6OE[wOC=>
SKVLB MWrDfZRwfG:6aXOgRZN{[Xl? NE\EboY4OiCq NIrlUndKSzVyPU[uOVQh|ryP NIPOSoE6ODB|NUKw
MCF7/VP16 M3v2VWN6fG:2b4jpZ{BCe3OjeR?= MlrTOVAh|rypL33M MUC3NkBp NWizfFVxUUN3ME2xOE4zKM7:TR?= M3L4dlkxOjJ5OUK=
CA755 NHH0TWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TCcFExKM7:TR?= NVu5fVhlPiCm MVTJR|UxRTBwMEG0JO69VQ>? Mn\xPVUzPjV5MB?=
CHO MkfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVSxNEDPxE1? MVK2JIQ> NEfvR3pKSzVyPUCuNFYh|ryP NUjFNW5TQTV{NkW3NC=>
Panc02 NWPyV2FzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWS4cnNEOTBizszN MkizOkBl M2XrXGlEPTB;MD6wOlUh|ryP MXK5OVI3PTdy
PC14 MmLOR5l1d3SxeHnjJGF{e2G7 Mme4OEBl Ml3CSG1UVw>? NHnHb2FKSzVyPUCuNlkh|ryP M3nISFk5OjJ3NEK=
HOP62 NIT3VYJEgXSxdH;4bYMhSXO|YYm= NXT2dHZrPzJiaB?= NWLHc2pVUUN3ME2wMlAxPCEQvF2= NFL5XW06QDd|Nk[x
SF-295 MlvSR5l1d3SxeHnjJGF{e2G7 NWD3NI5GPzJiaB?= Mny0TWM2OD1yLkCzOUDPxE1? NHLFfFk6QDd|Nk[x
MDA-MB-361 MYDDfZRwfG:6aXOgRZN{[Xl? NFTBNXgyKGh? NIHqZ|FFVVOR M2PJd2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2GQT3NRk0{PjFiZYjwdoV{e2mwZzDMZYNbKHerdHigTWM2OCCxZjCwMlAyOiEQvF2= MljCNVA{QTV2OUC=
MDA-MB-361 Mn[yR5l1d3SxeHnjJGF{e2G7 M4HmVVEhcA>? M2fKcmROW09? NGnpRVBEgXSxdH;4bYNqfHliYXfhbY5{fCCPRFGgUWIhOzZzIHX4dJJme3OrbnegZ4Fz[m:6eYDldJRq\GG|ZTDzeGNRTzJid3n0bEBKSzVyIH;mJFAvODF6IN88US=> MnLXNVA{QTV2OUC=
CCRF-SB NEPGenhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIX5bHQ1KGR? NFHMbYhFVVOR M4LKS2lEPTB;MD6wNUDPxE1? NWC4UmZKOTB2MUG0O|Y>
CHO-K1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnBS2F{PCCm NI\WPFFFVVOR M4rtV2lEPTB;MD60JO69VQ>? MUCxNFQyOTR5Nh?=
KB MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn6zOEBl NH3RcFRFVVOR Mo\0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDkdpVoNXKnc3nzeIFvfCCNQkfEJJdqfGhiSVO1NEBw\iByLk[1JO69VQ>? MkS2NVA1OTF2N{[=
KB M2TSXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1m1OlQh\A>? MUfEUXNQ M3\uemFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4Sg[JJ2\y2{ZYPpd5RidnRiS1LDZY1xf2m2aDDJR|UxKG:oIECuNFYh|ryP NF\hVGEyODRzMUS3Oi=>
KB M3;BUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV:0JIQ> M3HQemROW09? MoT0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDkdpVoNXKnc3nzeIFvfCCNQl3EVkB4cXSqIFnDOVAhd2ZiMD61JO69VQ>? NUS0TXByOTB2MUG0O|Y>
KB MoC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXi0JIQ> MYjEUXNQ NIHoXGpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIRzfWdvcnXzbZN1[W62IFvCWlIxSyC5aYToJGlEPTBib3[gNE41KM7:TR?= MVOxNFQyOTR5Nh?=
HTB-54 MXnDfZRwfG:6aXOgRZN{[Xl? MoHHNVAxKM7:TR?= NIfuUGtKSzVyPUGuNUDPxE1? NFjuWVEyODR5Nki2NS=>
MEL-AC NGjaVG1EgXSxdH;4bYMhSXO|YYm= NV3qR5MyOTByIN88US=> NF;qNXdKSzVyPUGuNkDPxE1? MnHxNVA1PzZ6NkG=
DU145 NFrNS2xEgXSxdH;4bYMhSXO|YYm= NITSNYg4OiCq NGPhN4FKSzVyPUCuNFUzQCEQvF2= NVn5TItKOTB2N{myPFI>
K562R MnPqR5l1d3SxeHnjJGF{e2G7 NGT3UmU4OiCq M{D5VWlEPTB;MD6wNVU3KM7:TR?= NELpXlIyODR5OUK4Ni=>
PACA-2 MWLDfZRwfG:6aXOgRZN{[Xl? M4ToOVYh\A>? NFvUVFBGTDVyPUCuNFA3OyEQvF2= MkPINVA1QTh{MUS=
3Y1 NHjNZZpEgXSxdH;4bYMhSXO|YYm= Mn3pO|IhcA>? MkPXS2k2OD1yLkCwN|gh|ryP MkTYNVA3QTF5MUC=
P388 NXfhUlVXS3m2b4TvfIlkKEG|c3H5 NX\zVHRCPzJiaB?= MoXLS2k2OD1yLkCxNkDPxE1? MmLuNVA3QTF5MUC=
HMV-1 M{C0fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYq1NmE2UUN3ME2wMlI5KM7:TR?= M13abVExPjl6NEO2
MKN-1 NX\TUoJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\4S2lEPTB;MD62OEDPxE1? Ml2zNVA3QTh2M{[=
PC14 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUf4ZZdTUUN3ME2xMlkh|ryP NF:xTpAyODZ7OESzOi=>
T24 M4jDbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILocmNKSzVyPUCuOlQh|ryP MoXwNVA3QTh2M{[=
U937 M2HuUmZ2dmO2aX;uJGF{e2G7 M4ryRlI1KGh? MlXqSG1UVw>? M3vJd2lvcGmkaYTzJIlv[2:{cH;yZZRqd25ib3[gX|NJZXSqeX3p[Ilv\SC5aYToJGlEPTBib3[gNE4yKM7:TR?= NF7T[GkyODd6MEmxNS=>
H460pv8/eto M{TTcGN6fG:2b4jpZ{BCe3OjeR?= MnW3NVAxKM7:TR?= MmjzOFghcA>? NXHqSJRSW2GuaX7l MX\JR|UxRTBwMEKg{txO NIT4e44yODd6MEmxNy=>
H460pv8 NUm4dXFGS3m2b4TvfIlkKEG|c3H5 NGO2[2gyODBizszN MkPzOFghcA>? NWjRZ|RzW2GuaX7l MkDCTWM2OD1yLkCwOEDPxE1? Ml\LNVA4QDB7MUO=
MDA-231 NXzPZ5lLS3m2b4TvfIlkKEG|c3H5 NFvNeWQyODBizszN MX[0PEBp NWH4UJRsW2GuaX7l MmLMR5l1d3SxeHnjbZR6KGGpYXnud5QhVUSDLUKzNUBk\WyuIDjFVk0tTUeIUjuscZV1[W62IIC1N{khf2m2aDDJR|UxKG:oIECuNFA3KM7:TR?= MoD1NVA4QDB7MUO=
MDA-468 MlPWR5l1d3SxeHnjJGF{e2G7 MUexNFAh|ryP MmHOOFghcA>? MWnTZYxqdmV? MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBOTEFvNE[4JINmdGxiKFXSMUwh[W2ybHnmbYVlKEWJRmKsJI12fGGwdDDwOVMqKHerdHigTWM2OCCxZjCwMlAxPSEQvF2= NGPpUFQyODd6MEmxNy=>
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IA-LM NFzPOpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4r0T2lEPTB;NkOuOVQhdk1? MWPTRW5ITVJ?
HCC2157 MnmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjCPXBKSzVyPU[zMlk2KG6P MX7TRW5ITVJ?
CTB-1 MoXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFu3[Y5KSzVyPU[0NFE6KG6P MoHhV2FPT0WU
NCI-H1437 MniyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHTZphzUUN3ME22OE43PCCwTR?= MV3TRW5ITVJ?
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ALL-PO MkS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHHPItKSzVyPU[1MlA{KG6P MY\TRW5ITVJ?
NCI-SNU-1 MknoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M332VGlEPTB;NkWuPFYhdk1? NEDLOI5USU6JRWK=
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DBTRG-05MG Mm\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rrfGlEPTB;NkeuNVEhdk1? NUfreYFWW0GQR1XS
PF-382 MnnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTZ5LkG3JI5O NYfucZNlW0GQR1XS
GT3TKB MlXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXBTWM2OD14Nz6xPUBvVQ>? MVjTRW5ITVJ?
SCC-3 NVK0VllMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2OwfmlEPTB;NkeuNlghdk1? MWrTRW5ITVJ?
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CAL-33 M2TwV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nzVmlEPTB;NkeuPFchdk1? MUTTRW5ITVJ?
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CPC-N NV2wOoxTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7LTWM2OD14OD60JI5O M{nkbXNCVkeHUh?=
A2780 NFixNXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnld2REUUN3ME22PE44QSCwTR?= NULXcZR2W0GQR1XS
Daudi M{jzOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWj6TGN[UUN3ME22PE46PiCwTR?= NGjoXVVUSU6JRWK=
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SW962 M1rrbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUD6bWt2UUN3ME22PU46PSCwTR?= MXrTRW5ITVJ?
MFE-296 NIf3cmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojOTWM2OD15MD60PUBvVQ>? M{OxW3NCVkeHUh?=
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HCC1599 MofMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYm3UWhrUUN3ME23Nk42PCCwTR?= MYnTRW5ITVJ?
HuCCT1 Mmq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTtTWM2OD15Mj65N{BvVQ>? MkH6V2FPT0WU
Calu-1 NUXo[JVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTd|Lk[gcm0> MkPaV2FPT0WU
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HSC-3 M4DqV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTd2LkWzJI5O MnS4V2FPT0WU
HCC1806 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTyfWR5UUN3ME23OE46PiCwTR?= MmftV2FPT0WU
VM-CUB-1 Mnr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fId2lEPTB;N{WuN|Yhdk1? NH7rXotUSU6JRWK=
HSC-4 M1m5S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTd3Lke2JI5O NHnPd3VUSU6JRWK=
NH-12 MnTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjOZ3E4UUN3ME23OkBvVQ>? M1ziVXNCVkeHUh?=
MDA-MB-468 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLiTWM2OD15Nj6xPEBvVQ>? NUe5VI9sW0GQR1XS
TUR M{Trfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDSTWM2OD15Nj6zNkBvVQ>? NHTMZ5VUSU6JRWK=
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CMK NEfVeHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPIXXJKSzVyPUe3MlQzKG6P NWDqXm5uW0GQR1XS
LB996-RCC NX34dHYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;STWM2OD15OD60OUBvVQ>? NGrn[HFUSU6JRWK=
NCI-H1650 NXLhUVE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LuOWlEPTB;N{iuOlIhdk1? MXXTRW5ITVJ?
DMS-273 NH\vdnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXWdHJxUUN3ME23PE46KG6P NWm5fnNqW0GQR1XS
NOS-1 Mk\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTd7LkG0JI5O NXnW[Y1LW0GQR1XS
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SUP-T1 NVzITXhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHVTWM2OD15OT63NkBvVQ>? MX7TRW5ITVJ?
A172 MkLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\nemlEPTB;OECuOVUhdk1? NICzR49USU6JRWK=
TE-12 NF;tVYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\HXWlEPTB;OEGuNFYhdk1? NX;zfVE5W0GQR1XS
MKN45 M3XLfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXETWM2OD16MT61NUBvVQ>? MVLTRW5ITVJ?
LoVo NInOfolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfJTWM2OD16MT64NkBvVQ>? MVHTRW5ITVJ?
SW1573 NGLYNmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\LTWM2OD16Mj64NUBvVQ>? MWDTRW5ITVJ?
ETK-1 NImxVItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPwN5U{UUN3ME24N{4xOSCwTR?= NXTlWYxjW0GQR1XS
ABC-1 NUDxN5RqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXpPFhKSzVyPUizMlQ2KG6P NUjqenR7W0GQR1XS
COLO-668 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4r0PGlEPTB;OESuOFchdk1? NHXs[5pUSU6JRWK=
UM-UC-3 NYq5WXk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnizTWM2OD16Nj6wNkBvVQ>? NUe5RnZKW0GQR1XS
BC-1 MoLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\rVGZKSzVyPUi2Mlc3KG6P MomzV2FPT0WU
PANC-10-05 NV;DPHZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXa[pVJUUN3ME24PE41PSCwTR?= NXjyZ2tNW0GQR1XS
ES3 NFPFSWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTh7LkS4JI5O MnixV2FPT0WU
TE-441-T Mn[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHIXYlKSzVyPUi5MlgzKG6P NW[wbGJrW0GQR1XS
KM-H2 NYrlWFJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnrRmpKSzVyPUmwMlY5KG6P NV7tTlVlW0GQR1XS
SH-4 NE\VcYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkK2TWM2OD17Mj6xNUBvVQ>? MUfTRW5ITVJ?
SF268 NFLiOIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTl{LkSyJI5O NHvROGlUSU6JRWK=
VMRC-RCZ M4Pi[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnWwTWM2OD17Mz6yOkBvVQ>? MWnTRW5ITVJ?
GI-ME-N M3;ab2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVexPYg6UUN3ME25N{4{OyCwTR?= M4C2XXNCVkeHUh?=
JEG-3 M3fwfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4[1dWlEPTB;OUWuNVIhdk1? NGjrU5dUSU6JRWK=
J-RT3-T3-5 NHvqZppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTl4LkOxJI5O MoG4V2FPT0WU
K5 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkiwTWM2OD17Nj65JI5O M4X0eXNCVkeHUh?=
EFO-27 NWn6d2dNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfoVHlKSzVyPUm3MlQ1KG6P MYrTRW5ITVJ?
SW1783 NFTLSmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIi4Zm9KSzVyPUm3Mlk6KG6P NIHBU4tUSU6JRWK=
CAL-39 M4jtcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\BN|ZtUUN3ME25PE4zPCCwTR?= NXjQT2pPW0GQR1XS
LS-441N MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPKTWM2OD17OT6wOkBvVQ>? M1HxfHNCVkeHUh?=
G-402 MmjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPRTWM2OD17OT6wPUBvVQ>? MknQV2FPT0WU
MES-SA M3TUTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjIVnNKSzVyPUm5MlU{KG6P MVPTRW5ITVJ?
FADU NWLYVZhYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXm5bJhxUUN3ME2xNFIvOThibl2= MYDTRW5ITVJ?
DJM-1 M2DPZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLZZ3BOUUN3ME2xNFIvOjVibl2= MVrTRW5ITVJ?
SU-DHL-1 NXfUbFF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M16yPGlEPTB;MUCyMlUhdk1? M2\4b3NCVkeHUh?=
KYSE-410 NEW0SWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfzUZFKSzVyPUGwN{41PiCwTR?= MXjTRW5ITVJ?
NCI-H1618 NX3YfINHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHL4WllKSzVyPUGwOE4{PSCwTR?= MWjTRW5ITVJ?
AU565 MmnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17sPGlEPTB;MUC0MlUyKG6P M{nTSXNCVkeHUh?=
SF126 NEP2UGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYWxPG1uUUN3ME2xNFQvPThibl2= NWfkTnlWW0GQR1XS
MMAC-SF NEnMT|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\PN2lEPTB;MUC2MlQ5KG6P M3;BTnNCVkeHUh?=
ChaGo-K-1 NHXIT5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTBdYREUUN3ME2xNFcvQTVibl2= NUHU[GpqW0GQR1XS
NCI-H596 MmnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTFyOD6wNUBvVQ>? M4HqNnNCVkeHUh?=
LXF-289 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTFyOT6yOEBvVQ>? NHvBWFZUSU6JRWK=
HCC1569 Ml7VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjneYZuUUN3ME2xNFkvOzRibl2= MlLkV2FPT0WU
NCI-H2170 M1POfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnkSmtKSzVyPUGwPU46OiCwTR?= MoXFV2FPT0WU
ARH-77 NWK4XG02T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnWTWlKSzVyPUGwPU46QSCwTR?= MX\TRW5ITVJ?
BOKU MoLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\jSVFKSzVyPUGxNE45PyCwTR?= M2LrUXNCVkeHUh?=
SJSA-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfoTWM2OD1zMUGuNFUhdk1? NXzBSWpJW0GQR1XS
SW626 MlTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzDV2g6UUN3ME2xNVEvPzFibl2= NIf1cJFUSU6JRWK=
EHEB M2\SXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPZW2VKSzVyPUGxNk42QSCwTR?= NXjtU49zW0GQR1XS
TE-10 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfZTWM2OD1zMUKuOlghdk1? MXjTRW5ITVJ?
MZ7-mel MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHMS2pKSzVyPUGxNk45PCCwTR?= M1vqV3NCVkeHUh?=
SAS MmX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTFzND60OUBvVQ>? Mn\aV2FPT0WU
TK10 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTFzND62JI5O MXrTRW5ITVJ?
SW13 M4e4O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWf2NJNoUUN3ME2xNVUvOjZibl2= MYHTRW5ITVJ?
HCC1937 Mn3xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzNfY1KSzVyPUGxOU45PCCwTR?= M4DMXHNCVkeHUh?=
SK-NEP-1 M33ReGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGH4U5NKSzVyPUGxOk4zPiCwTR?= MlKwV2FPT0WU
OVCAR-5 NYjRPJR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\aXYFKSzVyPUGxOk45OSCwTR?= NIXxR3lUSU6JRWK=
SW837 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3:zSGlEPTB;MUG3Mlk2KG6P NWHRTWN6W0GQR1XS
BFTC-909 M2LkOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37xVWlEPTB;MUG4MlQ5KG6P MULTRW5ITVJ?
SW872 NF72VVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4[wUWlEPTB;MUKwMlgyKG6P M2nGXnNCVkeHUh?=
SF539 MoTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorCTWM2OD1zMkGuO|Ihdk1? MUnTRW5ITVJ?
MLMA NEKwU21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HIXWlEPTB;MUKyMlA5KG6P MnjHV2FPT0WU
BL-41 NEDwdIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnBN|k6UUN3ME2xNlIvOjJibl2= NFX5N29USU6JRWK=
LB647-SCLC M2DKSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml33TWM2OD1zMkOuN|Uhdk1? NYLWfXRvW0GQR1XS
NCI-H1703 NHy1enRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPGTWM2OD1zMk[uOFIhdk1? NEX1PWFUSU6JRWK=
KURAMOCHI NGPNOIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nKWWlEPTB;MUK2Mlc3KG6P M2KydXNCVkeHUh?=
ATN-1 M3fGNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPKUG5KSzVyPUGyO{44KG6P MVPTRW5ITVJ?
SK-CO-1 NI\wbG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIWyNHJKSzVyPUGyPU4zOSCwTR?= NVnhW2N{W0GQR1XS
RPMI-7951 NYO1fVBGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEn4PZNKSzVyPUGzNE4yPCCwTR?= MXvTRW5ITVJ?
NCI-H1648 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXKN3dXUUN3ME2xN|EvQTRibl2= MmLhV2FPT0WU
NCI-H64 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjmfI9KSzVyPUGzNk43PSCwTR?= Mnj5V2FPT0WU
HT-3 Mki0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTmfXg6UUN3ME2xN|MvODRibl2= NIGyWJRUSU6JRWK=
NCI-H1770 NGHWRZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rXdmlEPTB;MUOzMlIyKG6P MnvzV2FPT0WU
NB13 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVviZ4tJUUN3ME2xN|QvPTVibl2= M{DzdnNCVkeHUh?=
NCI-H747 NYHC[HNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTF|NT6wNkBvVQ>? Mke4V2FPT0WU
ML-2 NHzYNXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTF|NT6xOkBvVQ>? MmrlV2FPT0WU
CA46 MliwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTodohKSzVyPUGzOk45QCCwTR?= M{fF[nNCVkeHUh?=
ES6 MoXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTvTWM2OD1zM{euNVIhdk1? NGjRb2hUSU6JRWK=
JiyoyeP-2003 M{\vb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTF|Nz64JI5O M4noOHNCVkeHUh?=
NMC-G1 NXix[HNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGP5NldKSzVyPUGzPU4yOyCwTR?= NWPyWpZbW0GQR1XS
U-698-M NHvaSWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnLfWJOUUN3ME2xN|kvPSCwTR?= MYLTRW5ITVJ?
LU-99A MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELGepNKSzVyPUG0Ok42PSCwTR?= MV3TRW5ITVJ?
NCI-H748 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfnT5VKSzVyPUG0O{4{OSCwTR?= NVfxSI5uW0GQR1XS
SK-MEL-3 NF;lU4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjETG5KSzVyPUG0O{43OSCwTR?= M{jpVHNCVkeHUh?=
SNB75 NVPFRpdIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTF2OD62OUBvVQ>? MX7TRW5ITVJ?
BB65-RCC NHLjUYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HKVGlEPTB;MUS5MlMyKG6P MXXTRW5ITVJ?
NCI-H1355 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmD1TWM2OD1zNUKuNlQhdk1? NHjldIhUSU6JRWK=
SCC-25 Mnj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DBWWlEPTB;MUWzMlc{KG6P NY\EOY11W0GQR1XS
OAW-42 MnzaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHFTWM2OD1zNUOuPFQhdk1? MXXTRW5ITVJ?
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NCI-H28 M1zM[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTFwN{SwO|gh|ryP MULTRW5ITVJ?
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COR-L88 NF;UUopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTRwM{m1PEDPxE1? MVXTRW5ITVJ?
RCM-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILUdWxKSzVyPUSuOFkzPzJizszN MnH1V2FPT0WU
JVM-3 MmPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknpTWM2OD12Lk[wOlE5KM7:TR?= MkT6V2FPT0WU
ECC4 MmfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzqcFlkUUN3ME20Mlc3PTRzIN88US=> NXrOTXpwW0GQR1XS
MDA-MB-453 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTRwOEWxN|Qh|ryP MUTTRW5ITVJ?
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D-502MG M{D1UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rKSmlEPTB;NT6yOFI3OiEQvF2= MonzV2FPT0WU
NCI-H2227 NXjWSXc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1G3[mlEPTB;NT6zOlI{OSEQvF2= NHvEO2dUSU6JRWK=
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HCC1395 NHPsVoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPrNWVJUUN3ME24MlE2OTJ{IN88US=> NYj2fWVZW0GQR1XS
EFE-184 M4nrUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRThwM{eyNVYh|ryP MYDTRW5ITVJ?
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SiHa MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLSTWM2OD1{Mz6zN|cyKM7:TR?= NVnQTHNPW0GQR1XS
RCC10RGB MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrGWGVKSzVyPUOwMlA3OTFizszN Mn7ZV2FPT0WU
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SK-MEL-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTN4Lke1OFch|ryP NHX0PHhUSU6JRWK=
NCI-H720 NGTxNWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfwV3lKSzVyPUSxMlk4OjZizszN NGjnXWhUSU6JRWK=
P31-FUJ NFHtUpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTR2LkOyPFQh|ryP NFPldGFUSU6JRWK=
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多くの細胞株試験データを見る場合、クリックしてください

体内試験 In vivo, Doxorubicin in combination with adenoviral MnSOD (AdMnSOD) plus 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) has the greatest effect in decreasing the volumes of MB231 tumors and prolonging survival of mice. [1] Although its use is limited by the chronic and acute toxic side effects it produces, Doxorubicin is essential in treating breast and oesophageal carcinomas, solid tumours in childhood, osteosarcomas, Kaposi's sarcoma, soft tissue sarcomas, and Hodgkin and non-Hodgkin lymphomas. [2]

お薦めの試験操作(参考用のみ)

動物試験:[1]
+ 展開
  • 動物モデル: Female athymic nude mice injected s.c. with MB231 cells
  • 製剤: Dissolved in DMSO, and diluted in saline
  • 投薬量: 3 mg/kg/day
  • 投与方法: Delivered intratumorly
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 100 mg/mL (172.41 mM) warming
Water 20 mg/mL (34.48 mM)
Ethanol Insoluble

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 579.98
化学式

C27H29NO11.HCl

CAS No. 25316-40-9
保管
in solvent
別名 NSC 123127

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03036904 Not yet recruiting Diffuse Large B-Cell Lymphoma|High Grade B-Cell Lymphoma Weill Medical College of Cornell University|Genentech, Inc.|Massachusetts General Hospital|M.D. Anderson Cancer Center February 6, 2017 Phase 1
NCT02659930 Recruiting Kaposi Sarcoma National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) January 4, 2016 Phase 1
NCT03042819 Not yet recruiting Soft Tissue Sarcoma University Health Network, Toronto|Karyopharm Therapeutics, Inc March 27, 2017 Phase 1
NCT03033914 Recruiting Hodgkin Lymphoma Memorial Sloan Kettering Cancer Center|Bristol-Myers Squibb|M.D. Anderson Cancer Center|City of Hope Medical Center January 25, 2017 Phase 1
NCT02957968 Recruiting Locally Advanced Breast Cancer|Invasive Adenocarcinoma of the Breast|Breast Cancer Stage II|Breast Cancer Stage III|Breast Cancer Stage IV Virginia Commonwealth University|Merck Sharp & Dohme Corp.|National Cancer Institute (NCI) January 24, 2017 Phase 2
NCT02377752 Active, not recruiting Neoplasm Eli Lilly and Company March 23, 2015 Phase 1

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    Why the IC50 of the compound varied over time in our measurement?

  • 回答:

    Sometimes the IC50 value might vary between different batch of compounds due to the slight differences in purity. If different IC50 was seen in the same batch of compound, the problem may lies in the process of dissolvement. Make sure that you see no particles and the solution is clear with your stock solution.

Topoisomerase信号経路図

相関Topoisomerase製品

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