Doxorubicin (Adriamycin) HCl

Licensed by Pfizer 製品コードS1208 別名:NSC 123127

Doxorubicin (Adriamycin) HCl化学構造

分子量(MW):579.98

Doxorubicin (Adriamycin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.

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文献中の使用例(32)

カスタマーフィードバック(8)

  • Enhancement of apoptotic response by addition of targeted agents lapatinib and sunitinib to doxorubicin in the same device reservoir at 24 hours. P values were determined using Student’s t test for all graphs.

    Sci Transl Med, 2015, 7(284): 284ra57 . Doxorubicin (Adriamycin) HCl purchased from Selleck.

    Cell viabilities with increasing concentrations of cisplatin (CP) and doxorubicin (DOXO) under normoxic and hypoxic condition for 48 hours were determined by MTT assay. IC50 values are presented as the means ?SDs (n=4) and * denotes p<0.05.

    Cancer Res 2014 74, 298-308. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • Cleavage of caspase-3, -9 and the expression of PARP were measured by western blot using b-actin as a loading control.

    Cell Cycle, 2017, 16(5):468-476. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    (C) & (D) Treatments with doxorubicin, cisplatin or AZD6244 further decreased the cell viability in RH30 cloned cells in which STAT3 or GP130 was knockdown by shRNA. (*P<.05, ** P <.01, *** P <.001).

    Curr Cancer Drug Targets, 2016, 16(7):631-8. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  •  

    Doxorubicin release of P(MAA-g-EG) and P(MAA-g-EG) containing nanoparticles in two-step pH conditions. Doxorubicinloaded P(MAA-g-EG) ,P(MAA-g-EG)-1.0NP ,P(MAA-g-EG)-2.5NP, and P(MAA-g-EG)-5.0NP crushed particles (75–150 um) were released in 1 PBS (pH 2.0) for 90 min. Then the pH was increased to 7.0 by adding 5N NaOH and release continued for 6 h.

    J Biomed Mater Res Part A 2012 10.1002/jbm.a.34064. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    Temporal uptake of free DOX or DOX-PCL63-b-PNVP90 micelles into K-562 (I) and DL (J) cells were studied by incubating in 24-well plates at a concentration of 50,000 cells per well. Representative images shown were obtained using a fluorescence microscope Eclipse 80i (Nikon, Japan) (Plan Fluor, 40X, NA 0.75 objective) equipped with blue and red filters for, Hoechst and Doxorubicin respectively (n = 3).

    PLoS One 2014 9, e94309. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • PLoS One 2013 8(1), e54595. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    CON+ -positive control (with FBS as chemoattractant); CON- - negative control (without chemoattractant); DOX -doxorubicin; WZ -WZ811; PF- PF-573228; * -significant difference compared to positive control: p<0.05; ** -significant difference compared to positive control: p<0.01; # -significant difference between combination and inhibitor only: p<0.05. Cancer cell invasion was analyzed using Transwell membranes assembled in 24-well plates and covered with a layer of Matrigel. COR-L23 cells were treated for 24 h with 50 nM DOX, 10 uM WZ811, 5 uM PF-573228 and combinations of inhibitors with 50 nM DOX. Similarly, RH460 cells were treated for 24 h with 1 uM DOX, 10 uM WZ811, 2.5 uM PF-573228 and combinations of inhibitors with 1 uM DOX. Applied doses were the ones that exerted the most pronounced synergistic effect on cytotoxicity level. After the incubation period, cells that invaded through matrigel and membranes were fixed in 4% paraformaldehyde-PBS and stained with Hoechst 33342 nuclear stain. Cells were visualized and counted under a fluorescent microscope at 10x magnification.

    2014 Dr Milica Pesic from Institute for Biological Research. Doxorubicin (Adriamycin) HCl purchased from Selleck.

製品安全説明書

Topoisomerase阻害剤の選択性比較

生物活性

製品説明 Doxorubicin (Adriamycin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.
ターゲット
Topo II [1]
(Tumor cells)
体外試験

Doxorubicin, an antibiotic anthracycline, is commonly considered to exert its anti-tumor activity at two fundamental levels, altering DNA and producing free radicals to trigger apoptosis of cancer cells through DNA damage. Doxorubicin can block the synthesis of DNA by intercalating into the DNA strand, and inhibits DNA topoisomerase II (TOP2). Doxorubicin is most effective when cells are rapidly proliferating and expressing high levels of TOP2. Additionally, Doxorubicin can trigger apoptosis by producing ceramide (which prompts apoptosis by activating p53 or other downstream pathways such as JNK), the degradation of Akt by serine threonine proteases, the mitochondrial release of cytochrome c, increased FasL (death receptor Fas/CD95 ligand) mRNA production, and a greater production of free radicals. [2] Pre-treatment with GSNO (nitrosoglutathione) suppresses the resistance in the doxorubicin-resistant breast cancer cell line MCF7/Dx, accompanied by enhanced protein glutathionylation and accumulation of doxorubicin in the nucleus. [3] Doxorubicin induced G2/M checkpoint arrest are attributed to elevated cyclin G2 (CycG2) expression and phospho-modification of proteins in the ataxia telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) signaling pathways. [5] Doxorubicin inhibits AMP-activated protein kinase (AMPK), resulting in SIRT1 dysfunction, p53 accumulation, and increased cell death in mouse embryonic fibroblasts (MEFs) and cardiomyocytes, which can be further sensitized by pre-inhibition of AMPK. [6] Doxorubicin elicits a marked heat shock response, and that either inhibition or silencing of heat shock proteins enhance the Doxorubicin apoptotic effect in neuroblastoma cells. Nanomolar Doxorubicin treatment of neuroblastoma cells causes dose-dependent over-ubiquitination of a specific set of proteins in the absence of measurable inhibition of proteasome, and loss of activity of ubiquitinated enzymes such as lactate dehydrogenase and α-enolase, the protein ubiquination patterns of which is similar to those with proteasome inhibitor Bortezomib, indicating that Doxorubicin may also exert its effect by damaging proteins. [8]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
L1210 MkThSpVv[3Srb36gRZN{[Xl? NUP3SIJGUW6qaXLpeIlwdiCxZjDSUmEhe3mwdHjld4l{KHerdHigSWQ2OCCxZjCwMlU5KM7:TR?= NV3KXIFKPDlyNUO2
Yoshida sarcoma M3\SN2Z2dmO2aX;uJGF{e2G7 NInUeVJKdmirYnn0bY9vKG:oIGuzTH1V\FJiaX7jc5Jxd3KjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNkDPxE1? M1HiOlE{OjJ7OE[=
CHO M3XSZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHTXpBWUUN3ME2wMlA3KM7:TR?= M3KyPVE{PTR5NUC=
8226 M{HpbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUe2UlZOUUN3ME2wMlA{OyEQvF2= MUexOFQ4PzNy
8226/ADR NUHUVHBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnCTWM2OD1yLkW2JO69VQ>? NUPGfIFNOTR2N{ezNC=>
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N417 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjrZXhsUUN3ME2wMlI{KM7:TR?= MX6xOFc6PTh3
H9 NWDjR5o6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fCXmlvcGmkaYTpc44hd2ZiSEmgZ4VtdHNiY3jyc45q[2GubImgbY5n\WO2ZXSge4l1cCC2aHWgTGlXNTFiKFi5M2lKUUJrIIfpeIghUUR3MDDv[kAxNjBzIN88US=> MVOxOVQ5Pjhz
T-C8166 MkWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJSFUxRTBwMEGg{txO MnfYNVU1QDZ6MR?=
T-H9 Mn7MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\uVmlFPTB;MD6wNUDPxE1? NHzqNI4yPTR6Nkix
T-MT4 NW\zc41WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJSFUxRTBwMEGg{txO MXixOVQ5Pjhz
SKMEL-5 NFPFcmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfhOZN4TUR3ME2zMlIh|ryP NVT2WoJROTZzM{e1Ny=>
MLM M1XLWmN6fG:2b4jpZ{BCe3OjeR?= NVfRcWFKTUR3ME2wMlE{KM7:TR?= NUXadWtEOTh5NUO1NC=>
KBM-3 NVzlTWQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2D1TWlEPTB;MD6wNlYh|ryP MmDUNVk6PTh5Nx?=
HT-29 NEDDfplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXOwMlAyKM7:Zx?= Ml\sOFghcA>? NXq2OZF{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJk> MkftNlc4QDR2OR?=
EMT6 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrZcoUxNjVizszN NFTWZoMyKGh? Mne3TY5pcWKrdHnvckBw\iCycn;sbYZmemG2aX;uJIJ6KG2nYYP1dolv\yCob4Kgd5Vzfmm4aX7nJIZz[WO2aX;ud{B4cXSqIFXEOVAhd2ZiMD6wNFAyKM7:TR?= MlrwO|Q2OjZ5NB?=
H2981 NVTteI9ZS3m2b4TvfIlkKEG|c3H5 M3HVd2lEPTB;MD61JO69VQ>? NHn1W2s4PzNzMEKz
LOX M{DLeWN6fG:2b4jpZ{BCe3OjeR?= MlTzTWM2OD1yLkC0NkDPxE1? MV63PFU{OzNz
C38 NHTpdJhEgXSxdH;4bYMhSXO|YYm= NGf4SIFKSzVyPUCuNFEh|ryP NG\2dmM5ODV5Mkmx
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AUC375 M3\6Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX20N5hsUUN3ME2wMlEyOiEQvF2= MWC4OlQ5PjBy
A2780-C25 NULrXFdMS3m2b4TvfIlkKEG|c3H5 NULRN4cyS3m2b4TvfIlkcXS7IHHnZYlve3Rib4jhcIlxdGG2aX6tdoV{cXO2YX70JGEzPzhyLVOyOUB4cXSqIFnDOVAhd2ZiMD6wOlMh|ryP MmjoPFg{OTd3NR?=
A2780-CP3 MoroR5l1d3SxeHnjJGF{e2G7 MmPyR5l1d3SxeHnjbZR6KGGpYXnud5Qh[2m|cHzheIlvNXKnc3nzeIFvfCCDMke4NE1EWDNid3n0bEBKSzVyIH;mJFAvODV4IN88US=> M3XVT|g5OzF5NUW=
A2780-DX5 M1rNfmN6fG:2b4jpZ{BCe3OjeR?= NIHUXIJEgXSxdH;4bYNqfHliYXfhbY5{fCCmb4jvdpVjcWOrbj3y[ZNqe3SjboSgRVI4QDBvRGi1JJdqfGhiSVO1NEBw\iByLkO1O{DPxE1? M3zHdFg5OzF5NUW=
MXF7 NYnYRoEzS3m2b4TvfIlkKEG|c3H5 NGL6W|RCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEB{\W6|aYTpeoUhVViINzD3bZRpKEmFNUCgc4YhOC5yMkig{txO M4S4fVg6PjB3NUi=
MXF7 NF3DcHJEgXSxdH;4bYMhSXO|YYm= MUnBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDtbZRwgGGwdILvcoUuemW|aYP0ZY51KE2[Rkege4l1cCCLQ{WwJI9nKDBwMEK4JO69VQ>? Mn[5PFk3ODV3OB?=
MXF7 MUDDfZRwfG:6aXOgRZN{[Xl? NFv5UJBCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBld3ixcoXibYNqdi2{ZYPpd5RidnRiTWjGO{B4cXSqIFnDOVAhd2ZiMT6xO|Ih|ryP MY[4PVYxPTV6
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MCF NX[0Uol5TnWwY4Tpc44hSXO|YYm= M{nMcXJmfmW{c3HsJI9nKFBvZ4CtcYVlcWG2ZXSgcZVtfGmmcoXnJJJme2m|dHHuZ4Uh[XO|ZYPz[YQh[XNiZX7oZY5k\W2nboSgbY4h[3m2b4TvfIlkcXS7IH;mJIFlemmjbYnjbY4> MkPzPFk5PDF3MR?=
C6 MVnDfZRwfG:6aXOgRZN{[Xl? Ml64Nk42KG2pL33M MnjCO|IhcA>? M1jx[2ROW09? NHzTbmREgXSxdH;4bYNqfHliYXfhbY5{fCC{YYSgR|Yh[2WubIOgZZQhPTBidXevcWwhfG9iMj61JI1oN22O MnP4PFk5QDZyNB?=
C6 MoHzSpVv[3Srb36gRZN{[Xl? M3vKUlIvPSCvZz;tUC=> M3Txb|QhcA>? M4TNe2ROW09? MXHJcohq[mm2aX;uJI9nKHS3YoXsbY4heG:ueX3ldol7[XSrb36= Mo\pPFk5QDZyNB?=
C6 NIn1WpBEgXSxdH;4bYMhSXO|YYm= MY[yMlUhdWdxbVy= MYO1JIg> NGLUPWlFVVOR MoTDR5l1d3SxeHnjbZR6KGG|c3Xzd4VlKGG|IHPlcIwhemWuZXHz[S=> NFjsZWs5QTh6NkC0
SKVLB NGCyWWNEgXSxdH;4bYMhSXO|YYm= NGnXU5k4OiCq M3KxbmlEPTB;Nj61OEDPxE1? M4jyN|kxODN3MkC=
MCF7/VP16 MYjDfZRwfG:6aXOgRZN{[Xl? MorzOVAh|rypL33M NE\hdFU4OiCq NHrNSIJKSzVyPUG0MlIh|ryP M{DLUVkxOjJ5OUK=
CA755 M1fuTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWSxNEDPxE1? NXr1XnM1PiCm Mmn4TWM2OD1yLkCxOEDPxE1? NX[1R5VMQTV{NkW3NC=>
CHO M2j2fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUSxNEDPxE1? MnfaOkBl M{fURmlEPTB;MD6wOkDPxE1? NVHmV2Z3QTV{NkW3NC=>
Panc02 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITReFQyOCEQvF2= NVzad45SPiCm MkTuTWM2OD1yLkC2OUDPxE1? MX[5OVI3PTdy
PC14 Mm\lR5l1d3SxeHnjJGF{e2G7 MY[0JIQ> MX\EUXNQ NFvjWlFKSzVyPUCuNlkh|ryP NHLkU3Q6QDJ{NUSy
HOP62 NEPwTJJEgXSxdH;4bYMhSXO|YYm= NG\neIs4OiCq MmWzTWM2OD1yLkCwOEDPxE1? MlHhPVg4OzZ4MR?=
SF-295 NILZTo5EgXSxdH;4bYMhSXO|YYm= M1;QbVczKGh? MUHJR|UxRTBwMEO1JO69VQ>? NVzaSWVkQTh5M{[2NS=>
MDA-MB-361 NWrre4poS3m2b4TvfIlkKEG|c3H5 MVKxJIg> NIjpV4ZFVVOR NULiOFNWS3m2b4TvfIlkcXS7IHHnZYlve3RiTVTBMW1DNTN4MTDlfJBz\XO|aX7nJGxi[1pid3n0bEBKSzVyIH;mJFAvODF{IN88US=> M{PpRVExOzl3NEmw
MDA-MB-361 MnXFR5l1d3SxeHnjJGF{e2G7 NEG1TJIyKGh? M3fheWROW09? MVnDfZRwfG:6aXPpeJkh[WejaX7zeEBOTEFiTVKgN|YyKGW6cILld5NqdmdiY3HyZo95gXCncITp[IF{\SC|dFPQS|Ihf2m2aDDJR|UxKG:oIECuNFE5KM7:TR?= MoX5NVA{QTV2OUC=
CCRF-SB MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;NfmdOPCCm NFTWe|RFVVOR NGjTTY9KSzVyPUCuNFEh|ryP M3noNlExPDFzNEe2
CHO-K1 MlTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXj2[ZdPPCCm Ml7QSG1UVw>? M3\ScGlEPTB;MD60JO69VQ>? M1TCUVExPDFzNEe2
KB NXe1R|N6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoToOEBl M4\0SWROW09? MlTURY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDkdpVoNXKnc3nzeIFvfCCNQkfEJJdqfGhiSVO1NEBw\iByLk[1JO69VQ>? MXSxNFQyOTR5Nh?=
KB M3n1SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4KwXFQh\A>? NXHKN5cyTE2VTx?= NHfodXlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIRzfWdvcnXzbZN1[W62IFvCR4FueHerdHigTWM2OCCxZjCwMlA3KM7:TR?= MlHVNVA1OTF2N{[=
KB NYfqRZZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1Gxb|Qh\A>? MWHEUXNQ MVTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHTyeYcuemW|aYP0ZY51KEuETVTSJJdqfGhiSVO1NEBw\iByLkWg{txO NGHrSYMyODRzMUS3Oi=>
KB M2H2cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrKOZM1KGR? NXfXdo1kTE2VTx?= M{fweGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4Sg[JJ2\y2{ZYPpd5RidnRiS1LWNlBEKHerdHigTWM2OCCxZjCwMlQh|ryP M{T5[FExPDFzNEe2
HTB-54 NEDveWJEgXSxdH;4bYMhSXO|YYm= NX3Repo{OTByIN88US=> M{LGXGlEPTB;MT6xJO69VQ>? NFi3VHkyODR5Nki2NS=>
MEL-AC MmjHR5l1d3SxeHnjJGF{e2G7 NXTYfJNpOTByIN88US=> NHjMT21KSzVyPUGuNkDPxE1? MUWxNFQ4Pjh4MR?=
DU145 MX3DfZRwfG:6aXOgRZN{[Xl? NG\nVng4OiCq NUPidm13UUN3ME2wMlA2OjhizszN NYHlb2FbOTB2N{myPFI>
K562R NGL5eHBEgXSxdH;4bYMhSXO|YYm= Ml[5O|IhcA>? MXzJR|UxRTBwMEG1OkDPxE1? NUPXbZN5OTB2N{myPFI>
PACA-2 NEO3dIlEgXSxdH;4bYMhSXO|YYm= M4HaSlYh\A>? M2P2R2VFPTB;MD6wNFY{KM7:TR?= NUjPOYFkOTB2OUiyNVQ>
3Y1 NFjzOlBEgXSxdH;4bYMhSXO|YYm= M2XVNlczKGh? M3vhTmdKPTB;MD6wNFM5KM7:TR?= NH7PcG0yODZ7MUexNC=>
P388 M{PObWN6fG:2b4jpZ{BCe3OjeR?= NInJd2E4OiCq M{O3cGdKPTB;MD6wNVIh|ryP NVS1NGxtOTB4OUG3NVA>
HMV-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nFXWlEPTB;MD6yPEDPxE1? MVSxNFY6QDR|Nh?=
MKN-1 NWLY[lJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\nTWM2OD1yLk[0JO69VQ>? NEjFbYIyODZ7OESzOi=>
PC14 MoLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTFwOTFOwG0> MYOxNFY6QDR|Nh?=
T24 NFu4T21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorOTWM2OD1yLk[0JO69VQ>? NYn1bGhXOTB4OUi0N|Y>
U937 MkfnSpVv[3Srb36gRZN{[Xl? M2DhZ|I1KGh? NXjCcGs{TE2VTx?= NWfP[HJlUW6qaXLpeJMhcW6lb4Lwc5JifGmxbjDv[kBcO0ifdHj5cYllcW6nIIfpeIghUUN3MDDv[kAxNjFizszN MljZNVA4QDB7MUG=
H460pv8/eto Ml;BR5l1d3SxeHnjJGF{e2G7 NETGN5EyODBizszN M2jtTFQ5KGh? MoHSV4FtcW6n NWfBTlFuUUN3ME2wMlAzKM7:TR?= MVSxNFc5ODlzMx?=
H460pv8 MlTCR5l1d3SxeHnjJGF{e2G7 MXuxNFAh|ryP MYK0PEBp NFnKR3FU[WyrbnW= NV7CPFFKUUN3ME2wMlAxPCEQvF2= M1H6[VExPzhyOUGz
MDA-231 NXTVeWVmS3m2b4TvfIlkKEG|c3H5 MnL2NVAxKM7:TR?= NV\qPIFvPDhiaB?= NFPqfnhU[WyrbnW= NFvmTVhEgXSxdH;4bYNqfHliYXfhbY5{fCCPRFGtNlMyKGOnbHygLGVTNSyHR1\SL{xufXSjboSgdFU{MSC5aYToJGlEPTBib3[gNE4xODZizszN MV[xNFc5ODlzMx?=
MDA-468 Mor4R5l1d3SxeHnjJGF{e2G7 Mk\5NVAxKM7:TR?= M4jyZVQ5KGh? M4HhbHNidGmwZR?= M{D5[WN6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2GQT20Olgh[2WubDCoSXIuNCCjbYDsbYZq\WRiRVfGVkwhdXW2YX70JJA2Oylid3n0bEBKSzVyIH;mJFAvODB3IN88US=> NF\JbmgyODd6MEmxNy=>
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IA-LM NHnScIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETYRm5KSzVyPU[zMlU1KG6P M3zQW3NCVkeHUh?=
HCC2157 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moj6TWM2OD14Mz65OUBvVQ>? M1TTNnNCVkeHUh?=
CTB-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnj4TWM2OD14NECxPUBvVQ>? MlTvV2FPT0WU
NCI-H1437 NHzxb5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIr5PFZKSzVyPU[0MlY1KG6P M1THc3NCVkeHUh?=
U251 NIHofpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDafYZKSzVyPU[0Mlg6KG6P NWq1RWVRW0GQR1XS
ALL-PO MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTZ3LkCzJI5O MUDTRW5ITVJ?
NCI-SNU-1 MkDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TYOGlEPTB;NkWuPFYhdk1? MVPTRW5ITVJ?
RPMI-6666 NF\rWmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rJUWlEPTB;NkWuPVkhdk1? M3yzXXNCVkeHUh?=
DBTRG-05MG NGjRNJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\2XY04UUN3ME22O{4yOSCwTR?= NX\wbHI1W0GQR1XS
PF-382 MlrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXL6enpvUUN3ME22O{4yPyCwTR?= M{HCV3NCVkeHUh?=
GT3TKB M{SzOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTZ5LkG5JI5O MYjTRW5ITVJ?
SCC-3 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHDTWM2OD14Nz6yPEBvVQ>? MkD1V2FPT0WU
LU-134-A MnPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3zTWM2OD14Nz62PEBvVQ>? MV3TRW5ITVJ?
CAL-33 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHPW5FQUUN3ME22O{45PyCwTR?= MYXTRW5ITVJ?
MC-IXC MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojwTWM2OD14Nz65JI5O MoDnV2FPT0WU
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A2780 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTZ6Lke5JI5O NXqyNIhTW0GQR1XS
Daudi MmPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mke5TWM2OD14OD65OkBvVQ>? NEXPbmdUSU6JRWK=
GI-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\JNoFKSzVyPU[5MlY2KG6P NHTVZpdUSU6JRWK=
SW962 NH;ob2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTZ7Lkm1JI5O NXjxOlBHW0GQR1XS
MFE-296 MnLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3j2XmlEPTB;N{CuOFkhdk1? NVHZdWpUW0GQR1XS
H4 NF\NTGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTzXpZXUUN3ME23NU42PiCwTR?= NE\XWoRUSU6JRWK=
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HCC1599 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWK3NINTUUN3ME23Nk42PCCwTR?= M{\uc3NCVkeHUh?=
HuCCT1 M1GyTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{n6TGlEPTB;N{KuPVMhdk1? M4PCUHNCVkeHUh?=
Calu-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfLR3pKSzVyPUezMlYhdk1? MkDwV2FPT0WU
DU-145 MnLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3G0VWlEPTB;N{OuO|Mhdk1? M4jYNHNCVkeHUh?=
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HSC-3 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDrTWM2OD15ND61N{BvVQ>? M3LRb3NCVkeHUh?=
HCC1806 NEnnO2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jYXmlEPTB;N{SuPVYhdk1? NVq3U2xFW0GQR1XS
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HSC-4 MoTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33VXmlEPTB;N{WuO|Yhdk1? NHK4NGJUSU6JRWK=
NH-12 NWHvO2pQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTd4IH7N NHrlXZZUSU6JRWK=
MDA-MB-468 NYDtRmpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrkTWM2OD15Nj6xPEBvVQ>? NVPrS3h5W0GQR1XS
TUR NWnhOIZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPH[oR4UUN3ME23Ok4{OiCwTR?= NI[3PWtUSU6JRWK=
TE-1 NVfqTYFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\3W4dHUUN3ME23Ok4{PSCwTR?= MljuV2FPT0WU
CMK NESwT|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2W4W2lEPTB;N{euOFIhdk1? NHuzS5ZUSU6JRWK=
LB996-RCC NV7TXoxMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTd6LkS1JI5O M{DRcHNCVkeHUh?=
NCI-H1650 M4X3VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTjbmN{UUN3ME23PE43OiCwTR?= MnziV2FPT0WU
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NOS-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PhUGlEPTB;N{muNVQhdk1? MYfTRW5ITVJ?
NB69 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTd7LkKgcm0> NF7lW2NUSU6JRWK=
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A172 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fLWWlEPTB;OECuOVUhdk1? NHvlfYJUSU6JRWK=
TE-12 M320dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3r3SmlEPTB;OEGuNFYhdk1? NITUN2xUSU6JRWK=
MKN45 NXPNNIp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRThzLkWxJI5O NW\v[4F5W0GQR1XS
LoVo M3e4[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TqSmlEPTB;OEGuPFIhdk1? NELaRWtUSU6JRWK=
SW1573 NHLreW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLzZmE1UUN3ME24Nk45OSCwTR?= M2iybXNCVkeHUh?=
ETK-1 NGi2e2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTh|LkCxJI5O MmLBV2FPT0WU
ABC-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTuTWM2OD16Mz60OUBvVQ>? NWK4W211W0GQR1XS
COLO-668 NIHCRVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTh2LkS3JI5O MoC1V2FPT0WU
UM-UC-3 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTh4LkCyJI5O NGfISXBUSU6JRWK=
BC-1 NYTX[JdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mly1TWM2OD16Nj63OkBvVQ>? MYTTRW5ITVJ?
PANC-10-05 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTh6LkS1JI5O M{fQ[XNCVkeHUh?=
ES3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTh7LkS4JI5O MUPTRW5ITVJ?
TE-441-T MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLoOJduUUN3ME24PU45OiCwTR?= M4XoZXNCVkeHUh?=
KM-H2 MmrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY[yZZc1UUN3ME25NE43QCCwTR?= NXTxeWVbW0GQR1XS
SH-4 MojnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTl{LkGxJI5O MYHTRW5ITVJ?
SF268 M3S4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NET1TJRKSzVyPUmyMlQzKG6P MnjQV2FPT0WU
VMRC-RCZ MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkW4TWM2OD17Mz6yOkBvVQ>? NVu5eXN3W0GQR1XS
GI-ME-N M3;ZT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jmeGlEPTB;OUOuN|Mhdk1? NF73TmJUSU6JRWK=
JEG-3 NX2yNIVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;n[VZwUUN3ME25OU4yOiCwTR?= M4fJZnNCVkeHUh?=
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K5 M4PqcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTSTWM2OD17Nj65JI5O MnHTV2FPT0WU
EFO-27 MkHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTl5LkS0JI5O MULTRW5ITVJ?
SW1783 MnT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3iTWM2OD17Nz65PUBvVQ>? NWeyfXU6W0GQR1XS
CAL-39 NIHodVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2O3SWlEPTB;OUiuNlQhdk1? NVHSN3dIW0GQR1XS
LS-441N NVPrS4ZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnVRYdXUUN3ME25PU4xPiCwTR?= M3jCSnNCVkeHUh?=
G-402 NYTESnJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzXRmtsUUN3ME25PU4xQSCwTR?= M2PyW3NCVkeHUh?=
MES-SA M4Hv[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\wd5BmUUN3ME25PU42OyCwTR?= MYTTRW5ITVJ?
FADU M4HwVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PxXWlEPTB;MUCyMlE5KG6P MXjTRW5ITVJ?
DJM-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmO1TWM2OD1zMEKuNlUhdk1? M2TuNHNCVkeHUh?=
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KYSE-410 NYTpc2xyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7RdW5iUUN3ME2xNFMvPDZibl2= Mk\iV2FPT0WU
NCI-H1618 M2O1dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTFyND6zOUBvVQ>? M4XJXXNCVkeHUh?=
AU565 NXP5XIlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUe2[XY4UUN3ME2xNFQvPTFibl2= MnXWV2FPT0WU
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MMAC-SF Ml3US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTFyNj60PEBvVQ>? M3foTnNCVkeHUh?=
ChaGo-K-1 NGHvSG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7ifW1KSzVyPUGwO{46PSCwTR?= MVLTRW5ITVJ?
NCI-H596 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjiZVNKSzVyPUGwPE4xOSCwTR?= NILO[FJUSU6JRWK=
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HCC1569 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXoT3N4UUN3ME2xNFkvOzRibl2= NWn0WGdlW0GQR1XS
NCI-H2170 Mm\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXi[pB1UUN3ME2xNFkvQTJibl2= MV3TRW5ITVJ?
ARH-77 M1X4OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTFyOT65PUBvVQ>? MnTZV2FPT0WU
BOKU MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGj3dm1KSzVyPUGxNE45PyCwTR?= M{jpR3NCVkeHUh?=
SJSA-1 NYLBWZgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4OxUmlEPTB;MUGxMlA2KG6P NHPNcGhUSU6JRWK=
SW626 M1rCeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjzR|k2UUN3ME2xNVEvPzFibl2= M4nhbXNCVkeHUh?=
EHEB NHTxOlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTFzMj61PUBvVQ>? MXXTRW5ITVJ?
TE-10 NFfnRnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzNbFhuUUN3ME2xNVIvPjhibl2= NHvTO4NUSU6JRWK=
MZ7-mel MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPMTWM2OD1zMUKuPFQhdk1? MX;TRW5ITVJ?
SAS MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTFzND60OUBvVQ>? MVzTRW5ITVJ?
TK10 NH[zXZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPOb4FrUUN3ME2xNVQvPiCwTR?= NXO0cm5bW0GQR1XS
SW13 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XkNGlEPTB;MUG1MlI3KG6P MkfuV2FPT0WU
HCC1937 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGn0U4NKSzVyPUGxOU45PCCwTR?= MUXTRW5ITVJ?
SK-NEP-1 NIX1[XdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnJTWM2OD1zMU[uNlYhdk1? MnGxV2FPT0WU
OVCAR-5 NUe1Oo5OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHm3[G1KSzVyPUGxOk45OSCwTR?= M1HmSXNCVkeHUh?=
SW837 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jyTmlEPTB;MUG3Mlk2KG6P MnfPV2FPT0WU
BFTC-909 NV\LNJp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTFzOD60PEBvVQ>? NIW3VIlUSU6JRWK=
SW872 M2\lOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTF{MD64NUBvVQ>? NG\mb49USU6JRWK=
SF539 NFT4e4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTkZWVKSzVyPUGyNU44OiCwTR?= MljDV2FPT0WU
MLMA MoLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTF{Mj6wPEBvVQ>? NVX2fYk5W0GQR1XS
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LB647-SCLC Mnm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPhS5JKSzVyPUGyN{4{PSCwTR?= NULhPYlQW0GQR1XS
NCI-H1703 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfmc2R{UUN3ME2xNlYvPDJibl2= M13LSXNCVkeHUh?=
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ATN-1 NIGz[|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTF{Nz63JI5O NYHPOVl1W0GQR1XS
SK-CO-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITJfGRKSzVyPUGyPU4zOSCwTR?= MmPrV2FPT0WU
RPMI-7951 NEezW|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjFNYJKUUN3ME2xN|AvOTRibl2= MVLTRW5ITVJ?
NCI-H1648 MonxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DvdGlEPTB;MUOxMlk1KG6P NVnh[5hjW0GQR1XS
NCI-H64 NXHGfot7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTF|Mj62OUBvVQ>? MV3TRW5ITVJ?
HT-3 NEXjTW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrDTXVoUUN3ME2xN|MvODRibl2= M2C2TXNCVkeHUh?=
NCI-H1770 Mm\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXzTWM2OD1zM{OuNlEhdk1? MnvZV2FPT0WU
NB13 NX;ZbGpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTF|ND61OUBvVQ>? MVHTRW5ITVJ?
NCI-H747 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXU[VdHUUN3ME2xN|UvODJibl2= NX7PVIY6W0GQR1XS
ML-2 M{D1d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDlc5BXUUN3ME2xN|UvOTZibl2= MXzTRW5ITVJ?
CA46 M1;POGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;oTWM2OD1zM{[uPFghdk1? MXLTRW5ITVJ?
ES6 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DSPGlEPTB;MUO3MlEzKG6P NFTSdHJUSU6JRWK=
JiyoyeP-2003 MkPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHvVWVKSzVyPUGzO{45KG6P M{Kxe3NCVkeHUh?=
NMC-G1 NVLkSoxbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVO5UGFQUUN3ME2xN|kvOTNibl2= NH:zcJdUSU6JRWK=
U-698-M MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrETIFPUUN3ME2xN|kvPSCwTR?= MWjTRW5ITVJ?
LU-99A NF7RPJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoP4TWM2OD1zNE[uOVUhdk1? MnnaV2FPT0WU
NCI-H748 MonvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LEV2lEPTB;MUS3MlMyKG6P NHzXTYFUSU6JRWK=
SK-MEL-3 M1rkW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoT4TWM2OD1zNEeuOlEhdk1? M2LOZXNCVkeHUh?=
SNB75 M4OyXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\XeIVqUUN3ME2xOFgvPjVibl2= NUfJOHlbW0GQR1XS
BB65-RCC NHr3cm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTF2OT6zNUBvVQ>? NVPJSm9RW0GQR1XS
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U031 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjtTWM2OD1|NUOuPFchdk1? NWXUOZpEW0GQR1XS
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MFE-280 MojBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTFwNk[4NVIh|ryP MkL0V2FPT0WU
S-117 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17HVmlEPTB;MT63NFUxPCEQvF2= MnfyV2FPT0WU
NCI-H1573 NVnzUZNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWS4WGlsUUN3ME2xMlcyPzN|IN88US=> M2TRXXNCVkeHUh?=
BT-20 NFj5UolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTFwN{SwOlgh|ryP NVXDR3ZTW0GQR1XS
NCI-H28 MnXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTFwN{SwO|gh|ryP M{GyTXNCVkeHUh?=
CaR-1 M{Hm[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;ocGlEPTB;MT63PFMzPCEQvF2= MlnDV2FPT0WU
LN-405 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TQUWlEPTB;MT64NFE1OyEQvF2= NH2zZmpUSU6JRWK=
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NCI-H889 Mlz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml31TWM2OD1zLkmzPFg3KM7:TR?= M1XJcHNCVkeHUh?=
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SW1088 NWHZVpBMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUf3eIZVUUN3ME2yMlA3QTNzIN88US=> NVjjSVJmW0GQR1XS
NB6 MmnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LuNGlEPTB;Mj6xPFUh|ryP MWXTRW5ITVJ?
KU-19-19 NFXTfGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTJwMk[5NVch|ryP MYrTRW5ITVJ?
A704 M3LXTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkflTWM2OD1{LkK5NVM2KM7:TR?= MlfXV2FPT0WU
EVSA-T NEXjeXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTJwM{CwPFkh|ryP MnvRV2FPT0WU
HCT-15 NXv2UVBqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjIeZFKSzVyPUKuN|U1PjZizszN MWrTRW5ITVJ?
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GMS-10 NXf1[JdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jKWmlEPTB;Mj6zPVc{QCEQvF2= MmiwV2FPT0WU
TGBC24TKB NIflR3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTJwNEG0Nlkh|ryP NED1W2xUSU6JRWK=
C2BBe1 M4nCWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rYfGlEPTB;Mj61NVMzQCEQvF2= M3ftOXNCVkeHUh?=
SK-N-DZ Ml;IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnt[4JKSzVyPUKuOVY2QTJizszN MXjTRW5ITVJ?
SK-N-AS M1;UWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLJTWM2OD1{LkezNFE2KM7:TR?= NYXTfIN6W0GQR1XS
T98G MnzwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLtTWM2OD1{LkiwOFAyKM7:TR?= MlvJV2FPT0WU
DMS-79 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2P3OmlEPTB;Mj65NFk5QCEQvF2= MXzTRW5ITVJ?
SNU-475 NIDHXllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnXZ5pKSzVyPUKuPVI2PzJizszN Moj1V2FPT0WU
COLO-792 M2XZbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\kNI9KSzVyPUOuNFI5PyEQvF2= Ml;pV2FPT0WU
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UACC-812 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTNwM{O3N|gh|ryP MnrEV2FPT0WU
Mewo M4\iS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfX[WgxUUN3ME2zMlQ3ODh4IN88US=> NEHHbVFUSU6JRWK=
COLO-824 NFPZTFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\NZ2lEPTB;Mz61O|M4QCEQvF2= Mn;uV2FPT0WU
SCC-9 NH65S3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTNwOUGzNFkh|ryP NUH6RpB{W0GQR1XS
CP50-MEL-B NX7jN5h4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPtTWM2OD1|Lkm4O|A{KM7:TR?= MofmV2FPT0WU
NCI-H345 NUXYUJFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M134SGlEPTB;ND6wNVE4PCEQvF2= M1e3fnNCVkeHUh?=
COR-L88 NY\xRYtQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjsTWM2OD12LkO5OVgh|ryP NGfJV25USU6JRWK=
RCM-1 NIDrWWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnvTWM2OD12LkS5NlczKM7:TR?= NEnOUYVUSU6JRWK=
JVM-3 M4fldWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nLe2lEPTB;ND62NFYyQCEQvF2= NYHsZo9HW0GQR1XS
ECC4 MmWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGL4ZnpKSzVyPUSuO|Y2PDFizszN NHrpWmlUSU6JRWK=
MDA-MB-453 Moi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTRwOEWxN|Qh|ryP NYrmU2ZsW0GQR1XS
SK-N-FI NFPkXWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTVwMkK4O|ch|ryP Mkn5V2FPT0WU
D-502MG NWixUmZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXJTWM2OD13LkK0NlYzKM7:TR?= NH3BRYNUSU6JRWK=
NCI-H2227 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYS4c5VxUUN3ME21MlM3OjNzIN88US=> NWeyRpk2W0GQR1XS
DMS-53 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rzTGlEPTB;Nj6xO|ExPiEQvF2= NXXMO5dlW0GQR1XS
LB771-HNC MknSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXRWZE4UUN3ME22MlQ3QDB4IN88US=> MlXFV2FPT0WU
BB49-HNC MlnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nJSGlEPTB;Nz60NVc6OSEQvF2= M1\ZWHNCVkeHUh?=
MDA-MB-415 MkLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{KzXGlEPTB;Nz61O|MxOyEQvF2= MlnpV2FPT0WU
TALL-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTdwOU[4PEDPxE1? NX;MdmRsW0GQR1XS
HCC1395 NX[5cWhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILTSolKSzVyPUiuNVUyOjJizszN NGr1UFRUSU6JRWK=
EFE-184 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRThwM{eyNVYh|ryP NFj4T|RUSU6JRWK=
EC-GI-10 NIXKfFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELQelNKSzVyPUiuOlg3QDZizszN Mkn6V2FPT0WU
TT M3fh[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPmTHVKSzVyPUmuNFY6PjZizszN NHjSUYtUSU6JRWK=
U-2-OS NGDPepVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1H6ZWlEPTB;OT64NVM6OyEQvF2= NFKxdWJUSU6JRWK=
SHP-77 NXHs[JQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33IfWlEPTB;OT65NFI6KM7:TR?= MUDTRW5ITVJ?
HCC1143 NGrJfGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDqPI1KSzVyPUGwMlQ4QTdizszN NXXaW3Z7W0GQR1XS
A498 NFOzTHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTF6LkK5O|Yh|ryP MnfxV2FPT0WU
LS-513 NY\ZXI9rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml2xTWM2OD1zOD62NFk{KM7:TR?= MVXTRW5ITVJ?
K052 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\YN4tKSzVyPUKxMlQ1OThizszN MWXTRW5ITVJ?
SiHa MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUCxRWJMUUN3ME2yN{4{OzdzIN88US=> M4fKR3NCVkeHUh?=
RCC10RGB NEPjVIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorITWM2OD1|MD6wOlEyKM7:TR?= NHPtcoJUSU6JRWK=
NCI-SNU-16 MmjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjGTWM2OD1|MT6xPFM3KM7:TR?= MULTRW5ITVJ?
SNU-C1 NIXQc3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnq5TWM2OD1|Mj60NVc2KM7:TR?= M4PwSXNCVkeHUh?=
C32 NWrQeoliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3F[pRHUUN3ME2zNk45PzJizszN NVzadYZjW0GQR1XS
SW684 M17UeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDteGNZUUN3ME2zOE4yPTZzIN88US=> NV7mfHNZW0GQR1XS
SK-MEL-28 NYPaUmExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXMSHJrUUN3ME2zOU42Ozd5IN88US=> NYnzNmxHW0GQR1XS
SK-MEL-1 NE\jZ2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPPTWM2OD1|Nj63OVQ4KM7:TR?= MXvTRW5ITVJ?
NCI-H720 NF7PcoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoO5TWM2OD12MT65O|I3KM7:TR?= MnXuV2FPT0WU
P31-FUJ M17Remdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\lTWM2OD12ND6zNlg1KM7:TR?= NIO5eHlUSU6JRWK=
NCI-H524 NXu0XVE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTR6LkiyOFgh|ryP NFLzZm1USU6JRWK=

多くの細胞株試験データを見る場合、クリックしてください

体内試験 In vivo, Doxorubicin in combination with adenoviral MnSOD (AdMnSOD) plus 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) has the greatest effect in decreasing the volumes of MB231 tumors and prolonging survival of mice. [1] Although its use is limited by the chronic and acute toxic side effects it produces, Doxorubicin is essential in treating breast and oesophageal carcinomas, solid tumours in childhood, osteosarcomas, Kaposi's sarcoma, soft tissue sarcomas, and Hodgkin and non-Hodgkin lymphomas. [2]

お薦めの試験操作(参考用のみ)

動物試験:[1]
+ 展開
  • 動物モデル: Female athymic nude mice injected s.c. with MB231 cells
  • 製剤: Dissolved in DMSO, and diluted in saline
  • 投薬量: 3 mg/kg/day
  • 投与方法: Delivered intratumorly
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 100 mg/mL (172.41 mM) warming
Water 20 mg/mL (34.48 mM)
Ethanol Insoluble

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 579.98
化学式

C27H29NO11.HCl

CAS No. 25316-40-9
保管
in solvent
別名 NSC 123127

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03036904 Not yet recruiting Diffuse Large B-Cell Lymphoma|High Grade B-Cell Lymphoma Weill Medical College of Cornell University|Genentech, Inc.|Massachusetts General Hospital|M.D. Anderson Cancer Center February 6, 2017 Phase 1
NCT02659930 Recruiting Kaposi Sarcoma National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) January 4, 2016 Phase 1
NCT03042819 Not yet recruiting Soft Tissue Sarcoma University Health Network, Toronto|Karyopharm Therapeutics, Inc March 27, 2017 Phase 1
NCT03033914 Recruiting Hodgkin Lymphoma Memorial Sloan Kettering Cancer Center|Bristol-Myers Squibb|M.D. Anderson Cancer Center|City of Hope Medical Center January 25, 2017 Phase 1
NCT02957968 Recruiting Locally Advanced Breast Cancer|Invasive Adenocarcinoma of the Breast|Breast Cancer Stage II|Breast Cancer Stage III|Breast Cancer Stage IV Virginia Commonwealth University|Merck Sharp & Dohme Corp.|National Cancer Institute (NCI) January 24, 2017 Phase 2
NCT02377752 Active, not recruiting Neoplasm Eli Lilly and Company March 23, 2015 Phase 1

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    Why the IC50 of the compound varied over time in our measurement?

  • 回答:

    Sometimes the IC50 value might vary between different batch of compounds due to the slight differences in purity. If different IC50 was seen in the same batch of compound, the problem may lies in the process of dissolvement. Make sure that you see no particles and the solution is clear with your stock solution.

Topoisomeraseシグナル伝達経路

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