Luminespib (AUY-922, NVP-AUY922)

製品コードS1069 別名:VER-52296

Luminespib (AUY-922, NVP-AUY922)化学構造

分子量(MW):465.54

Luminespib (AUY-922, NVP-AUY922)は一種の高度有効なHSP90阻害剤で、無細胞試験でHSP90α/βに作用する時のIC50値が13 nM /21 nMですが、HSP90家族メンバーGRP94とTRAP-1に少し弱い作用を表して、いずれかの小分子HSP90リガンドと緊密に結合することができます。臨床2期。

サイズ 価格(税別) 在庫  
JPY 53120.00 あり
JPY 26560.00 あり
JPY 44820.00 あり
JPY 78020.00 あり

カスタマーフィードバック(3)

  • U2OS_exo cells were incubated with AUY922 for 20 h at the indicated concentrations before stimulation with TNFα (30 ng/mL) for 30 min and immunostaining to detect NF-κB (p65). DMSO 1%, cells stimulated by TNFα in the absence of AUY922. Representative pictures used to quantify nuclear and cytoplasmic localization of NF-κB.

    Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

    J Biol Chem 2013 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

  • Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922  (ie, induction of HSP72 and depletion of client proteins such as ERBB2, CRAF and CDK4) in BT474 breast cancer cell line. GAPDH was used as loading control.

     

     

    2011 Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

製品安全説明書

HSP (e.g. HSP90)阻害剤の選択性比較

生物活性

製品説明 Luminespib (AUY-922, NVP-AUY922)は一種の高度有効なHSP90阻害剤で、無細胞試験でHSP90α/βに作用する時のIC50値が13 nM /21 nMですが、HSP90家族メンバーGRP94とTRAP-1に少し弱い作用を表して、いずれかの小分子HSP90リガンドと緊密に結合することができます。臨床2期。
ターゲット
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
体外試験

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK NYHvd4F6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkn6TWM2OD1yLkCwNFEzPSEQvF2= NUXKc4R5W0GQR1XS
MV-4-11 NYj3VZJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13aRmlEPTB;MD6wNFA2PThizszN NI\rOFdUSU6JRWK=
NALM-6 MlXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMECwPFQzKM7:TR?= MUnTRW5ITVJ?
HOS MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfZTWM2OD1yLkCwNVM5KM7:TR?= NFP3V2ZUSU6JRWK=
HT-144 NXftVo5xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFr0b5pKSzVyPUCuNFAyPTVizszN M2\n[XNCVkeHUh?=
SW1710 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjt[2RKSzVyPUCuNFAyQDZizszN NX\uXo5kW0GQR1XS
TE-8 MnnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2n3SGlEPTB;MD6wNFI{PyEQvF2= MlTKV2FPT0WU
ES1 NWXWfXVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnRe2ZbUUN3ME2wMlAxOjZ4IN88US=> M2PPfHNCVkeHUh?=
CCF-STTG1 NV7VWFA6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2H6SGlEPTB;MD6wNFI6PyEQvF2= NGPhWmFUSU6JRWK=
PSN1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2D3WGlEPTB;MD6wNFMyQCEQvF2= MkHaV2FPT0WU
CAL-51 M1;6U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nERWlEPTB;MD6wNFMzPSEQvF2= MoPRV2FPT0WU
MCF7 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fPfGlEPTB;MD6wNFM{PSEQvF2= NXn0WXduW0GQR1XS
SK-HEP-1 M4LQ[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwMECzN|Yh|ryP M4LKTXNCVkeHUh?=
LCLC-103H NYPDWFNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXUTWM2OD1yLkCwOFMh|ryP MWTTRW5ITVJ?
HMV-II NFHETHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWq5XnVXUUN3ME2wMlAxPDR7IN88US=> NGTtbZFUSU6JRWK=
MES-SA M3HIPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\JU45pUUN3ME2wMlAxPDV{IN88US=> NFTvXFZUSU6JRWK=
SK-LMS-1 NHLR[3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMEC0OVgh|ryP NFT0PWNUSU6JRWK=
639-V MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYewWlVXUUN3ME2wMlAxPDh3IN88US=> NWLuNI4yW0GQR1XS
SIG-M5 NV;Qc5pTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwMEC0PFkh|ryP M4XpWHNCVkeHUh?=
LOUCY MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vqfGlEPTB;MD6wNFUxPSEQvF2= NX3rXIFnW0GQR1XS
HSC-2 NXvJOGN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHiUI5KSzVyPUCuNFA2OThizszN MV;TRW5ITVJ?
EW-13 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTke4FTUUN3ME2wMlAxPTF6IN88US=> M3;tbnNCVkeHUh?=
RT-112 MkK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMEC1N|Uh|ryP M2jId3NCVkeHUh?=
NKM-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4ry[mlEPTB;MD6wNFU1PyEQvF2= NF7LVWdUSU6JRWK=
KYSE-180 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTBwMEC1PFYh|ryP Mnz2V2FPT0WU
SW1783 NGHxXI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwMEC1PVEh|ryP MXLTRW5ITVJ?
A431 NULpZWFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7nSIRHUUN3ME2wMlAxPjB5IN88US=> MonVV2FPT0WU
SK-OV-3 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHrTWM2OD1yLkCwOlMh|ryP MoS5V2FPT0WU
RPMI-7951 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmGxTWM2OD1yLkCwOlMyKM7:TR?= M36wVnNCVkeHUh?=
Capan-2 NETEcFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjvTWM2OD1yLkCwOlM5KM7:TR?= NUnwcYJkW0GQR1XS
HSC-3 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknOTWM2OD1yLkCwOlQyKM7:TR?= M2e5VHNCVkeHUh?=
786-0 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojZTWM2OD1yLkCwOlY{KM7:TR?= NUnrdFhWW0GQR1XS
Daoy NGSyenlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHpTWM2OD1yLkCwOlk2KM7:TR?= NVe2NVNWW0GQR1XS
KGN MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33EV2lEPTB;MD6wNFcxOyEQvF2= MVnTRW5ITVJ?
EW-16 NYfaZmJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;DTWM2OD1yLkCwO|Q6KM7:TR?= M1joXnNCVkeHUh?=
EW-7 NFfD[ldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMEC3OVQh|ryP MUDTRW5ITVJ?
IGROV-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwMEC4NVQh|ryP Ml21V2FPT0WU
8505C M4TYOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLL[3k4UUN3ME2wMlAxQDJzIN88US=> MYnTRW5ITVJ?
RKO Ml7xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PGZmlEPTB;MD6wNFgzPiEQvF2= MYDTRW5ITVJ?
GDM-1 NIrOfpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwMEC4OEDPxE1? MnfRV2FPT0WU
IST-MEL1 M3;mcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMEC4OVIh|ryP M1\yRnNCVkeHUh?=
RPMI-6666 NEThN5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XMZ2lEPTB;MD6wNFg2OiEQvF2= M{HIVHNCVkeHUh?=
SNG-M M4DlOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPRemtKSzVyPUCuNFA5PTZizszN MoKyV2FPT0WU
KS-1 M2HJbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMEC4OVkh|ryP NX61bIQ{W0GQR1XS
RXF393 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWC4OHZOUUN3ME2wMlAxQDZizszN NFTKclJUSU6JRWK=
CAL-12T MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjR[ZdZUUN3ME2wMlAxQTJ{IN88US=> M3j1d3NCVkeHUh?=
BFTC-905 M13oS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3:xfmlEPTB;MD6wNFk{QCEQvF2= M4m2W3NCVkeHUh?=
SK-MES-1 NXruZo95T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV25NWVjUUN3ME2wMlAxQTR3IN88US=> MUHTRW5ITVJ?
BB30-HNC NWr5[mo2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnL5TWM2OD1yLkCwPVUzKM7:TR?= MX;TRW5ITVJ?
AN3-CA MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HxOmlEPTB;MD6wNVAyPyEQvF2= NITYSFZUSU6JRWK=
EFO-27 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMEGwNVch|ryP NULS[WVIW0GQR1XS
G-401 NEfLeJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PQcmlEPTB;MD6wNVAzPSEQvF2= MmKyV2FPT0WU
BPH-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMEGwN{DPxE1? Mo[xV2FPT0WU
NCI-H727 MnTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMEGwN{DPxE1? MlPiV2FPT0WU
SNU-423 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMEGwOVMh|ryP MV;TRW5ITVJ?
KYSE-270 NXSwelhDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LoTGlEPTB;MD6wNVA2QSEQvF2= NH7SVIlUSU6JRWK=
AGS MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPsTWM2OD1yLkCxNFYyKM7:TR?= NWXKS3F[W0GQR1XS
NCI-H2228 Mn\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwMEGwOlQh|ryP MXjTRW5ITVJ?
SW954 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVz0ZXlsUUN3ME2wMlAyODdzIN88US=> M{m1[XNCVkeHUh?=
769-P M3;HNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDpPJdKSzVyPUCuNFExPzNizszN MXTTRW5ITVJ?
BB49-HNC NIixOHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMEGwO|ch|ryP M4PKdHNCVkeHUh?=
IA-LM NV7VU5dHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3m0e2lEPTB;MD6wNVA5PiEQvF2= M{jqdHNCVkeHUh?=
NB69 M4DoXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTZWnBKSzVyPUCuNFEyODJizszN NIKwUXNUSU6JRWK=
C8166 NFzCOpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU[4WnZJUUN3ME2wMlAyOTJ7IN88US=> NEXudIVUSU6JRWK=
NCI-H1299 NF;iUWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HnOmlEPTB;MD6wNVE2PCEQvF2= M{nDUnNCVkeHUh?=
YKG-1 NILhSlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn:0TWM2OD1yLkCxNVYh|ryP NFvjc45USU6JRWK=
PANC-03-27 M4DQNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMEGxOlIh|ryP M33WOnNCVkeHUh?=
YT NG\Ze4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFH3dm5KSzVyPUCuNFEyPzlizszN MknCV2FPT0WU
CAL-85-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXXZo5[UUN3ME2wMlAyOTl{IN88US=> MkTHV2FPT0WU
GT3TKB MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHqyUZRKSzVyPUCuNFEzODJizszN NHzLTFZUSU6JRWK=
BB65-RCC NHrnZ3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TyfWlEPTB;MD6wNVIxPCEQvF2= MYDTRW5ITVJ?
ES6 M4Hnemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnTN4ViUUN3ME2wMlAyOjZzIN88US=> M3jwdHNCVkeHUh?=
MHH-ES-1 NHrJfXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPZW4tsUUN3ME2wMlAyOjZ|IN88US=> MlfTV2FPT0WU
QIMR-WIL MonvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnYTWM2OD1yLkCxNlY6KM7:TR?= NFm2VWlUSU6JRWK=
SNU-C2B M1LjU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMEGyO|Ih|ryP NIToWWlUSU6JRWK=
OCI-AML2 NVy1SZJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMEGyPFEh|ryP NIrjZ3BUSU6JRWK=
DU-145 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMEGyPUDPxE1? NUn1S2sxW0GQR1XS
SW982 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7wTWM2OD1yLkCxNlk{KM7:TR?= MXrTRW5ITVJ?
MFH-ino NFnWN5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DSZmlEPTB;MD6wNVI6OyEQvF2= NXrSO|FJW0GQR1XS
A427 NHi0[WNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HYWmlEPTB;MD6wNVI6QSEQvF2= MUnTRW5ITVJ?
LCLC-97TM1 NEW1fopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMEGzJO69VQ>? M2nqbHNCVkeHUh?=
AM-38 M3\jV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PSRmlEPTB;MD6wNVMxOiEQvF2= NWLOZ29ZW0GQR1XS
K5 NV7xUWhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoL6TWM2OD1yLkCxN|A5KM7:TR?= MYXTRW5ITVJ?
T84 Ml60S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HUXmlEPTB;MD6wNVM{OSEQvF2= NIjKZ2RUSU6JRWK=
TE-15 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojHTWM2OD1yLkCxN|M3KM7:TR?= NF7PUJdUSU6JRWK=
NCI-H460 MkjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDMTWM2OD1yLkCxN|M3KM7:TR?= NIXEWHRUSU6JRWK=
NTERA-S-cl-D1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnhXnZuUUN3ME2wMlAyOzN7IN88US=> NHX2OJVUSU6JRWK=
KYSE-450 M36zTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXmTWM2OD1yLkCxN|Q6KM7:TR?= MlvZV2FPT0WU
H4 NWPKeG9kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fFeWlEPTB;MD6wNVM3PiEQvF2= NX;rTnc5W0GQR1XS
LC-2-ad M4LGWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfkTWM2OD1yLkCxN|ch|ryP M4XlZ3NCVkeHUh?=
GAMG M3zDRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTSV4hIUUN3ME2wMlAyOzdzIN88US=> NYflfJlDW0GQR1XS
TK10 NHrSRnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMEGzPFIh|ryP MoHmV2FPT0WU
NCI-H2122 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV[0VWJ3UUN3ME2wMlAyOzh2IN88US=> MYHTRW5ITVJ?
KM12 NG\xVFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Kxb2lEPTB;MD6wNVM6QSEQvF2= MkPNV2FPT0WU
CAL-39 NXizPVEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{i1SGlEPTB;MD6wNVQzKM7:TR?= MVnTRW5ITVJ?
RPMI-2650 MmGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HLdmlEPTB;MD6wNVQ{OiEQvF2= Mn3nV2FPT0WU
KYSE-510 NXHPblNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLKfVBKSzVyPUCuNFE1PDJizszN M4LYV3NCVkeHUh?=
KALS-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{myZmlEPTB;MD6wNVQ3PiEQvF2= M3\3OXNCVkeHUh?=
NCI-H1648 MkfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLnPFFKSzVyPUCuNFE1QTlizszN M2m1XXNCVkeHUh?=
ES4 MlzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nZbWlEPTB;MD6wNVUxOiEQvF2= MXfTRW5ITVJ?
C-33-A M{H5W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwMEG1NFkh|ryP Mo\nV2FPT0WU
MIA-PaCa-2 NHPWfGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XFXmlEPTB;MD6wNVUxQSEQvF2= NF\FWnFUSU6JRWK=
Becker NVz6VYV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMEG1NVQh|ryP MljRV2FPT0WU
HOP-62 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFe2bHBKSzVyPUCuNFE2PDJizszN Mnf2V2FPT0WU
TE-1 M4LySGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nScWlEPTB;MD6wNVU5OSEQvF2= M1PreXNCVkeHUh?=
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Daudi MnXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmewTWM2OD1yLkCzN|c3KM7:TR?= MVXTRW5ITVJ?
RS4-11 M{[2[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMEOzPFMh|ryP NUm0cmg6W0GQR1XS
JiyoyeP-2003 NVvKe4FnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3iSHZiUUN3ME2wMlA{Ozh6IN88US=> MU\TRW5ITVJ?
BL-70 M4LUZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rPcmlEPTB;MD6wN|M5QSEQvF2= MWHTRW5ITVJ?
OS-RC-2 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfzXG1KSzVyPUCuNFM{QTZizszN NVzDc3RLW0GQR1XS
SF268 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfN[INKSzVyPUCuNFM1ODFizszN M3XCe3NCVkeHUh?=
BV-173 M3W4d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M376VGlEPTB;MD6wN|QzPiEQvF2= NYLOb5gyW0GQR1XS
DMS-273 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3H3[2lEPTB;MD6wN|Q4QSEQvF2= MlT2V2FPT0WU
22RV1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMEO1NFch|ryP NGm0ZWJUSU6JRWK=
ES8 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXmTWM2OD1yLkCzOVM5KM7:TR?= NF;vNZdUSU6JRWK=
KYSE-150 NF;EXplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwMEO2NFgh|ryP M{HPV3NCVkeHUh?=
HCC1569 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPKWJU{UUN3ME2wMlA{PjB6IN88US=> M3O4WXNCVkeHUh?=
NB5 NF7UeVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moq1TWM2OD1yLkCzOlE{KM7:TR?= Moi1V2FPT0WU
G-402 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwMEO2NVQh|ryP MUfTRW5ITVJ?
NCI-H1693 MmL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;6OGlEPTB;MD6wN|YyPyEQvF2= NWPIeFVGW0GQR1XS
LB2241-RCC M1vqO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4D3cGlEPTB;MD6wN|Y1OiEQvF2= MlvIV2FPT0WU
KP-4 NH\6Xo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPOPJdPUUN3ME2wMlA{PjZ|IN88US=> M2GySnNCVkeHUh?=
ML-2 MoL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwMEO2O|Eh|ryP NYDqbXR{W0GQR1XS
KU812 NWnWend4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3ri[2lEPTB;MD6wN|Y5PCEQvF2= M1izNXNCVkeHUh?=
LS-411N MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTifpBQUUN3ME2wMlA{PzNzIN88US=> NF[yNIZUSU6JRWK=
OAW-42 M{fpemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMEO3OFch|ryP M3;tWnNCVkeHUh?=
HCC38 NUXtTFE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV60cWJXUUN3ME2wMlA{PzdzIN88US=> NUT4U4l4W0GQR1XS
Ca-Ski NX[zbGEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlj4TWM2OD1yLkCzO|g1KM7:TR?= MVLTRW5ITVJ?
Calu-3 NUTYWnlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\lTWM2OD1yLkCzO|g6KM7:TR?= MXXTRW5ITVJ?
KYSE-70 M2XTZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LwUWlEPTB;MD6wN|gyOiEQvF2= M2j3U3NCVkeHUh?=
D-392MG MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwMEO4OFIh|ryP NUL5S45IW0GQR1XS
OVCAR-4 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUGxR3FtUUN3ME2wMlA{QDV6IN88US=> Mn;wV2FPT0WU
Detroit562 M1;tUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PpWGlEPTB;MD6wN|g4OiEQvF2= M2KycnNCVkeHUh?=
HEL MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWn4VXRMUUN3ME2wMlA{QDlzIN88US=> MV7TRW5ITVJ?
MONO-MAC-6 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXONGZKSzVyPUCuNFM5QTNizszN M4\INHNCVkeHUh?=
LoVo M33ZO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vJS2lEPTB;MD6wN|k{OyEQvF2= MX\TRW5ITVJ?
U-2-OS NVLGOIQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwMEO5N|Uh|ryP M3GwVnNCVkeHUh?=
A172 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVKwRpRYUUN3ME2wMlA{QTVizszN MWfTRW5ITVJ?
OCUB-M Moe1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7nb5RTUUN3ME2wMlA{QTZzIN88US=> MmniV2FPT0WU
SW48 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Px[WlEPTB;MD6wOFA{OSEQvF2= MUjTRW5ITVJ?
HC-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jrcWlEPTB;MD6wOFA3QSEQvF2= M1GyTHNCVkeHUh?=
KOSC-2 NWnvS2xFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwMESxNUDPxE1? M4m4UHNCVkeHUh?=
HDLM-2 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3GTYhKSzVyPUCuNFQyOTRizszN NILoU2NUSU6JRWK=
CTV-1 NGPiVJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DFV2lEPTB;MD6wOFEyPiEQvF2= NIfBR2JUSU6JRWK=
SH-4 M325dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjtUnBKSzVyPUCuNFQyPDFizszN M4jSPHNCVkeHUh?=
SW756 NIT4fGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMESxOVch|ryP MYXTRW5ITVJ?
GCT M1T6Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMESxOlEh|ryP MUTTRW5ITVJ?
CHL-1 M2jTRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHQbHZKSzVyPUCuNFQyPjlizszN NWTGe40yW0GQR1XS
LAMA-84 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn:xTWM2OD1yLkC0NVcyKM7:TR?= Mn;5V2FPT0WU
LS-1034 Mn3DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHRTWM2OD1yLkC0NVkyKM7:TR?= NVLBT2pJW0GQR1XS
NCI-H358 MknHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfWNYxKSzVyPUCuNFQzOTJizszN M1\UNnNCVkeHUh?=
NB13 NGDGS3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwMESyNlch|ryP NG\RXZFUSU6JRWK=
TE-9 Ml[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnBWYpiUUN3ME2wMlA1OjN5IN88US=> MlvmV2FPT0WU
OE33 NGDRbmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwMESyOFEh|ryP Mn\vV2FPT0WU
CAL-120 NYS1TFhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrBUFZKSzVyPUCuNFQzPDFizszN NV6zXmlOW0GQR1XS
DJM-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjuVWZkUUN3ME2wMlA1Ojd{IN88US=> MkTwV2FPT0WU
SK-MEL-24 MkL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMESyPFMh|ryP MVrTRW5ITVJ?
VA-ES-BJ MmjSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnJTWM2OD1yLkC0NlkzKM7:TR?= Mo\0V2FPT0WU
MMAC-SF M{\Kc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLsdVBKSzVyPUCuNFQzQTdizszN NVHJd4RJW0GQR1XS
MZ7-mel M4nzWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwMESzN{DPxE1? Ml;SV2FPT0WU
BxPC-3 M3ftfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3oWFUyUUN3ME2wMlA1OzRzIN88US=> NGH5dGFUSU6JRWK=
HT-29 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMESzOVch|ryP NHLCSmZUSU6JRWK=
SK-MEL-30 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzlWo1KSzVyPUCuNFQ{PjJizszN NGDFU5RUSU6JRWK=
CAL-33 M2jNcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\nZ5VKSzVyPUCuNFQ{PzVizszN MlfnV2FPT0WU
COLO-680N NVnrSmc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HFcmlEPTB;MD6wOFQxPyEQvF2= MoXrV2FPT0WU
NH-12 NUjYb5RnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\JZ|JKSzVyPUCuNFQ1PCEQvF2= NIPuNGdUSU6JRWK=
HCC1937 M{HHeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTpfGE{UUN3ME2wMlA1PDV4IN88US=> NYK2N5piW0GQR1XS
IMR-5 MnfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLwTWM2OD1yLkC0OFkh|ryP MVjTRW5ITVJ?
MC-CAR M4rKT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTUVWxKSzVyPUCuNFQ2PjlizszN MlnuV2FPT0WU
NCI-H747 M{fvemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmf3TWM2OD1yLkC0OVch|ryP MXHTRW5ITVJ?
NCI-H1792 NV7OfWlkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M32zV2lEPTB;MD6wOFU5OSEQvF2= NFS2VYpUSU6JRWK=
SW13 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoH2TWM2OD1yLkC0OVkh|ryP MoXQV2FPT0WU
MLMA Mn7QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXrVYtRUUN3ME2wMlA1PjB7IN88US=> NXHVXolwW0GQR1XS
U251 NWHmflNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV:yOZdDUUN3ME2wMlA1PzZ|IN88US=> Mnv1V2FPT0WU
U031 NYq0SI1pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFT0VG1KSzVyPUCuNFQ4PzFizszN MYTTRW5ITVJ?
ME-180 NH7QcXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHzb|ZKSzVyPUCuNFQ4QDJizszN MkLiV2FPT0WU
SK-MEL-3 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGe0dINKSzVyPUCuNFQ5ODJizszN MUHTRW5ITVJ?
MOLT-4 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;vVmlEPTB;MD6wOFgxOyEQvF2= M2PHbnNCVkeHUh?=
PF-382 MljpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\hZ3BKSzVyPUCuNFQ5OjZizszN NUnzR2RGW0GQR1XS
NUGC-3 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;ZV3lXUUN3ME2wMlA1QDJ5IN88US=> MVvTRW5ITVJ?
NCI-H1417 MmD3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX33Z2piUUN3ME2wMlA1QDlizszN MYDTRW5ITVJ?
COLO-205 MlW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPHTWM2OD1yLkC0PVE6KM7:TR?= MWPTRW5ITVJ?
TE-441-T NGrqfndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMES5N{DPxE1? NIO2cI5USU6JRWK=
MKN1 NXT2OHNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\4[lNEUUN3ME2wMlA1QTNizszN MUPTRW5ITVJ?
UM-UC-3 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMES5OUDPxE1? M4jhU3NCVkeHUh?=
SF126 NITiPVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwMEWwNUDPxE1? M4TlXnNCVkeHUh?=
LB1047-RCC NWDOV5NlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwMEWwN|Eh|ryP NFPn[W9USU6JRWK=
A253 M1vDTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NED4SoxKSzVyPUCuNFUxPTJizszN NHjOe5BUSU6JRWK=
NCI-H1963 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIL4fnVKSzVyPUCuNFUyPzZizszN NGrObGtUSU6JRWK=
VM-CUB-1 NHrKbVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwMEWzNVEh|ryP M1vifXNCVkeHUh?=
T-24 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMEWzPFQh|ryP MYnTRW5ITVJ?
K-562 NFrzfJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoS0TWM2OD1yLkC1N|g4KM7:TR?= NYnS[FRsW0GQR1XS
ARH-77 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXztOVJXUUN3ME2wMlA2Ozl3IN88US=> NGjl[pVUSU6JRWK=
CA46 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW[0U4h2UUN3ME2wMlA2PDNizszN M2rmV3NCVkeHUh?=
HCC70 MkLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfaTWM2OD1yLkC1OFUzKM7:TR?= M1njWHNCVkeHUh?=
ST486 M4rIN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\CT5dKSzVyPUCuNFU2OjVizszN MmLkV2FPT0WU
COLO-741 MkDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;vTWM2OD1yLkC1OVMyKM7:TR?= NWjZ[mlpW0GQR1XS
SK-PN-DW M3nTXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPuS3dKSzVyPUCuNFU2QDhizszN NHrTOGVUSU6JRWK=
BL-41 MlrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPOPWpKSzVyPUCuNFU2QTZizszN M1L5N3NCVkeHUh?=
D-263MG MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3uxTWlEPTB;MD6wOVY5OyEQvF2= NF:3[3hUSU6JRWK=
KE-37 M4LnVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3v2PWlEPTB;MD6wOVY5OyEQvF2= M{fYcnNCVkeHUh?=
LU-134-A NXvYW2oxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmX0TWM2OD1yLkC1O|E2KM7:TR?= Mne5V2FPT0WU
HCC2157 NV;vN5psT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1Tic2lEPTB;MD6wOVc{OyEQvF2= MXjTRW5ITVJ?
GAK NIPGcItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\rbmlEPTB;MD6wOVc{PCEQvF2= M1;KTnNCVkeHUh?=
IST-SL2 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nRSGlEPTB;MD6wOVc1OyEQvF2= M3zrfnNCVkeHUh?=
KMOE-2 M1TsOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mni1TWM2OD1yLkC1O|Q6KM7:TR?= Mlv2V2FPT0WU
SW1573 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwMEW4NFIh|ryP Mme3V2FPT0WU
SCC-9 NGnlSG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfjOVJKSzVyPUCuNFU5PyEQvF2= MYPTRW5ITVJ?
MDA-MB-361 NVnVNYZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\TVo5KSzVyPUCuNFU5PzJizszN NWfhfJVYW0GQR1XS
BHT-101 MkXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzrWlU1UUN3ME2wMlA2QDd4IN88US=> NX\tO5JHW0GQR1XS
NCI-H1770 NF\pdZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwMEW4O|kh|ryP M{PNWnNCVkeHUh?=
UACC-893 MkfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMEW4PVYh|ryP MWXTRW5ITVJ?
NCI-H226 NYfqVmtmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHU[XAxUUN3ME2wMlA2QTh6IN88US=> M37uXXNCVkeHUh?=
HLE MojsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrl[YtIUUN3ME2wMlA3ODh{IN88US=> MVXTRW5ITVJ?
NCI-H1703 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\pSGlEPTB;MD6wOlE4QCEQvF2= NIH1cYlUSU6JRWK=
KURAMOCHI MkXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPUTWM2OD1yLkC2NVg6KM7:TR?= M2f2[XNCVkeHUh?=
RH-1 NWOxclRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDDTWM2OD1yLkC2NlMh|ryP NUPX[oxoW0GQR1XS
DSH1 MnHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nzdmlEPTB;MD6wOlI4KM7:TR?= MlrNV2FPT0WU
CAMA-1 MnjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXXbphxUUN3ME2wMlA3OzB|IN88US=> NIPocGhUSU6JRWK=
NCI-H1437 M{DxeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvFNZJKSzVyPUCuNFY{OjhizszN NWrMSWVIW0GQR1XS
HuP-T4 NFXWSpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3z6fGlEPTB;MD6wOlU5PiEQvF2= NVXrXZJVW0GQR1XS
HCT-15 M3rnTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwME[1PVch|ryP M4Pq[nNCVkeHUh?=
NCCIT MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vsd2lEPTB;MD6wOlYxPCEQvF2= NVTsXlE{W0GQR1XS
BOKU MkKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXkUY5GUUN3ME2wMlA3Pjd2IN88US=> NWnabWxQW0GQR1XS
FADU NX:1[I9LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfGPWZKSzVyPUCuNFY4PDVizszN M{O3[HNCVkeHUh?=
SUP-T1 NUfIOWZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHWwOVRKSzVyPUCuNFY4PiEQvF2= Ml7KV2FPT0WU
L-363 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwME[5NFEh|ryP NX;uXWlFW0GQR1XS
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SK-MEL-1 NWDq[4hvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjsbI1KSzVyPUGuNlA2QTVizszN NUOzSoJLW0GQR1XS
TALL-1 M{XWTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1X5RmlEPTB;MT6yOVE3PSEQvF2= Ml;IV2FPT0WU
RO82-W-1 NGXpc3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\KS3BKSzVyPUGuN|M{OzlizszN Mn\qV2FPT0WU
NCI-H1581 NIPhXIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfmTWM2OD1zLkO1Olg4KM7:TR?= M3zBWnNCVkeHUh?=
NCI-H748 MoLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\zZ3p{UUN3ME2xMlM2PzN6IN88US=> NX7HTHduW0GQR1XS
HCC1187 MnLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3oNmZVUUN3ME2xMlU2PTJ{IN88US=> MXvTRW5ITVJ?
EoL-1-cell NXnJWWNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXP5fWdMUUN3ME2xMlU5QDh7IN88US=> Mlz4V2FPT0WU
HuO-3N1 NYDCcllCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDvSW5KSzVyPUGuPFM1OTJizszN NVq2TGNRW0GQR1XS
NCI-H1793 Mn[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTFwOEe1PVMh|ryP MVjTRW5ITVJ?
Caov-3 NGn5OWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTJwMEC2NlUh|ryP NITEcpZUSU6JRWK=
JAR MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjJSJFKSzVyPUKuNFc6OiEQvF2= M1S1bnNCVkeHUh?=
SK-MEL-28 NUfXfIV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4S2[WlEPTB;Mj6xPFA6QCEQvF2= Mke4V2FPT0WU
EM-2 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LuV2lEPTB;Mj6yNFI6OyEQvF2= MV7TRW5ITVJ?
Mewo NWTITGtKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\qW2Q2UUN3ME2yMlIzOjZ3IN88US=> MUDTRW5ITVJ?
NCI-H720 NGm2ZmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTJwMk[1PFUh|ryP M2HadXNCVkeHUh?=
CAL-54 NILqRXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zPbGlEPTB;Mj6yOlc6PSEQvF2= M4\XeXNCVkeHUh?=
MC116 MoLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGD0WIdKSzVyPUKuN|Y{QTdizszN NYfRTpA1W0GQR1XS
DG-75 MkC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTJwNEi1O|Yh|ryP NHvmeINUSU6JRWK=
HCC1143 NGexS|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnqyTWM2OD1{LkWwOlU5KM7:TR?= NFXud4hUSU6JRWK=
FTC-133 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHW1XGtKSzVyPUKuOVM3QDlizszN MmS2V2FPT0WU
AsPC-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XXPWlEPTB;Mj61N|kzQSEQvF2= MVTTRW5ITVJ?
NCI-H889 NXy2cXIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXoUHJKSzVyPUKuOVY4ODZizszN MnXSV2FPT0WU
HT55 NXG0TopFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnROlFKSzVyPUKuOlIxOTlizszN M2nhcnNCVkeHUh?=
UMC-11 NEHGdpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1frU2lEPTB;Mj63PFcyPSEQvF2= NXLGTIlzW0GQR1XS
P12-ICHIKAWA MnvCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTJwOEKwOFYh|ryP MlzaV2FPT0WU
HCC1395 NETKW|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF:4XolKSzVyPUKuPVg3ODJizszN NV[yXWxGW0GQR1XS
D-283MED NVv0T5hmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4L3[2lEPTB;Mz6xPFk{PyEQvF2= NXqwPVk3W0GQR1XS
COLO-800 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTNwM{O4PVch|ryP MnLUV2FPT0WU
MFM-223 M4jQTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzDTWM2OD1|LkO2NFk4KM7:TR?= M3jOPHNCVkeHUh?=
TE-5 NG\Je5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnzSlVKSzVyPUSuOVYyPDdizszN NFPVRYxUSU6JRWK=
NCI-H209 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTEb29KSzVyPUSuO|g2PzJizszN M1jUfHNCVkeHUh?=
SiHa NWK2SJdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XRVmlEPTB;ND65OVIxOyEQvF2= NFjNUm5USU6JRWK=
NCI-H1395 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVSwXmV5UUN3ME21MlExPjN|IN88US=> NEn3RYdUSU6JRWK=
A498 NULzVI9rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzJT3hKSzVyPUWuNlEzPTFizszN M1;5fXNCVkeHUh?=
ES5 MnLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTVwNkGxO|gh|ryP NGTm[FNUSU6JRWK=
MDA-MB-157 M2fqUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHqe3lKSzVyPUWuOlY1PDNizszN M13HcHNCVkeHUh?=
NCI-H1623 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFKxcmFKSzVyPUWuPFM2PTZizszN NXvMPXJ4W0GQR1XS
RPMI-8866 NHvQbVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXMTWM2OD13Lki0O|kzKM7:TR?= NV;0UnBlW0GQR1XS
LC-1F M{H2Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTZwMEmyPVEh|ryP MlzXV2FPT0WU
TCCSUP NFXIcndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTZwNkCzOFkh|ryP MmGyV2FPT0WU
TT Ml3CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XCT2lEPTB;OD6zN|AxQSEQvF2= NXy3UFRXW0GQR1XS
NCI-H1838 NIO0XGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nadmlEPTB;OD61NVc{OSEQvF2= MYfTRW5ITVJ?
NCI-H322M M3jsUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTlwMU[yPFEh|ryP MlzTV2FPT0WU
NCI-H187 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TISWlEPTB;OT61NVg{PSEQvF2= NFroOIhUSU6JRWK=
SBC-1 MofqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITO[GdKSzVyPUmuPVM3PTZizszN MoXkV2FPT0WU
SCC-3 NHzpWGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfsTWM2OD1zMD61Olc6KM7:TR?= NVrRfnJ{W0GQR1XS
SW948 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTFyLke1NVEh|ryP NF34d3JUSU6JRWK=
CPC-N M1fSPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLLTWM2OD1zMT6wNFch|ryP MnrlV2FPT0WU
TGBC24TKB NFi1TIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvmTWM2OD1zMz61Nlkh|ryP M2ntXnNCVkeHUh?=
NCI-H2452 M1XKSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPkUFVRUUN3ME2xOE44OyEQvF2= NFnQZVZUSU6JRWK=
Hs-578-T MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTF6LkW3OVkh|ryP NUHaPJlJW0GQR1XS
DV-90 MlO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTF6Lkm5OFUh|ryP MknkV2FPT0WU
NCI-H1563 MlfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTF7Lke4PFgh|ryP M2G2PHNCVkeHUh?=
SW780 M1XXd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nVb2lEPTB;MkGuNVMyQCEQvF2= M4TWPHNCVkeHUh?=
NCI-H345 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PLOmlEPTB;MkGuPFc4QSEQvF2= NIDkfWRUSU6JRWK=
LB771-HNC NFy1cYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnJTWM2OD1{Mj60PFE{KM7:TR?= NYTDcIo5W0GQR1XS
RT4 MluwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfxV5dKSzVyPUKzMlMzQDJizszN MV;TRW5ITVJ?
NCI-H82 NFqzPVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIS1VnpKSzVyPUKzMlU2OjZizszN NXnTT4dSW0GQR1XS
NCI-H524 NWDEfZFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\PVWlEPTB;MkSuN|gyOiEQvF2= M3zzPXNCVkeHUh?=
SNU-C1 M1zTVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmftTWM2OD1{ND65NVA2KM7:TR?= NX7TVpdDW0GQR1XS
NCI-SNU-16 MmLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3f1S2lEPTB;NEiuN|E1OiEQvF2= NFXofpJUSU6JRWK=

多くの細胞株試験データを見る場合、クリックしてください

体内試験 Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]

お薦めの試験操作(参考用のみ)

キナーゼ試験:[3]
+ 展開

Kinase assay:

NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
細胞試験: [1]
+ 展開
  • 細胞株: Human gastric cancer cells NCI-N87
  • 濃度: 1 μM
  • 反応時間: 3 days
  • 実験の流れ: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
    (参考用のみ)
動物試験:[3]
+ 展開
  • 動物モデル: Female NCr athymic mice bearing WM266.4 human melanoma xenografts
  • 製剤: In DMSO and diluted in sterile saline/Tween 20
  • 投薬量: 50 mg/kg
  • 投与方法: Administered via i.v. or i.p.
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 93 mg/mL (199.76 mM) warming
Ethanol 31 mg/mL (66.58 mM)
Water Insoluble
体内 順序で溶剤を入れること:
1% DMSO+30% polyethylene glycol+1% Tween 80
30 mg/mL

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 465.54
化学式

C26H31N3O5

CAS No. 747412-49-3
保管
別名 VER-52296

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01784640 Active, not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 2014 Phase 1
NCT01922583 Active, not recruiting Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01854034 Active, not recruiting Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2
NCT01772797 Completed Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Active, not recruiting Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2
NCT01613950 Completed Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein Novartis Pharmaceuticals|Novartis December 2012 Phase 1

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

HSP (e.g. HSP90)信号経路図

HSP (e.g. HSP90) Inhibitors with Unique Features

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Tags: Luminespib (AUY-922, NVP-AUY922)を買う | Luminespib (AUY-922, NVP-AUY922) ic50 | Luminespib (AUY-922, NVP-AUY922)供給者 | Luminespib (AUY-922, NVP-AUY922)を購入する | Luminespib (AUY-922, NVP-AUY922)費用 | Luminespib (AUY-922, NVP-AUY922)生産者 | オーダーLuminespib (AUY-922, NVP-AUY922) | Luminespib (AUY-922, NVP-AUY922)化学構造 | Luminespib (AUY-922, NVP-AUY922)分子量 | Luminespib (AUY-922, NVP-AUY922)代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID