Verteporfin

製品コードS1786 別名:CL 318952

Verteporfin 化学構造

分子量(MW):718.79

Verteporfin is a small molecule that inhibits TEAD–YAP association and YAP-induced liver overgrowth. It is also a potent second-generation photosensitizing agent derived from porphyrin.

サイズ 価格(税別)  
JPY 53120.00
JPY 161020.00

カスタマーフィードバック(3)

  • Verteporfin treatment inhibits proliferation and induces apoptosis of Tsc1-null cells in vivo. Mice were administered i.p. with vehicle or verteporfin at a dose of 100 mg/kg every other day for 10 d before sacrifice. Mice were sacrificed at 6 wk of age. Three independent experiments were performed and mice in different treatments were pooled for analysis. Percentage of Ki67 and αSMA double-positive cells in α-SMA+ mesenchymal lesions in the indicated kidneys. Immunofluorescence staining and counting were performed on three sagittal sections from different kidney regions for each mouse.

    J Exp Med 2014 211(11), 2249-63. Verteporfin purchased from Selleck.

    The indicated cell lines were treated with control (Ctrl) or YAP-targeting siRNAs and growth assessed by XTT proliferation assays at the indicated time points. The mean and +SD are shown for three independent experiments. (Left panel, *, P < 0.05, significantly different from U87Rictor DMSO; Right panel, *, P < 0.05, significantly different from H4Rictor DMSO).

    J Biol Chem, 2015, 290(32): 19387-401 . Verteporfin purchased from Selleck.

  • The levels of YAP, phospho-YAP (S127), and its downstream targeted molecules CTGF and CYR61 were analyzed by Western blotting after UM cells were exposed to verteporfin for 24 hours.

    Am J Cancer Res, 2016, 6(12):2816-2830.. Verteporfin purchased from Selleck.

製品安全説明書

VDA阻害剤の選択性比較

生物活性

製品説明 Verteporfin is a small molecule that inhibits TEAD–YAP association and YAP-induced liver overgrowth. It is also a potent second-generation photosensitizing agent derived from porphyrin.
ターゲット
VDA [1]
(Endothelial cells)
YAP/TEAD interaction [3]
体外試験

Verteporfin is about four times more efficient in absorbing light at wavelengths that penetrate tissues best (i.e., around 700 nm) and thus provides a much higher cytotoxic effect than hematoporphyrin (10 times more in human adherent cell lines). Verteporfin is lipophilic and is more readily taken up by malignant or activated cells, compared with normal or resting cells. Verteporfin binds with LDL to form a complex, which is then taken up into proliferating cells (e.g., neovascular endothelial cells) probably via LDL receptors and endocytosis. Verteporfin therapy achieves complete angiographic occlusion of the neovascular compartment by thrombosis of vascular channels, following selective endothelial damage. Verteporfin therapy selectively induces reproducible and isolated choriocapillary occlusion without alteration of overlying photoreceptors or ganglion cells, as shown by light and electron microscopy. [1] Verteporfin conbined with light rapidly exhibits apoptotic changes reflected by caspase-3 and caspase-9 activation and PARP cleavage in HL-60 cells, changes that are blocked by the general caspase inhibitor ZVAD.fmk. [2]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HL-60 NXnWVlZqTnWwY4Tpc44h[XO|YYm= MnqyglExOCCwZz;tUC=> NWrVZmJnTE2VTx?= MVfpcoNz\WG|ZYOgSG5CKG[{YXft[Y51[XSrb36gcIV3\Wy| NHHhPXAyODZyN{exNC=>
HL-60 NEHhNFFkgXSxdH;4bYNqfHliYYPzZZk> M2rkeJ4yODBibnevcWw> MX3EUXNQ MWjpcohq[mm2czDj[YxtKH[rYXLpcIl1gQ>? NVHkVpNtOTB4MEe3NVA>
Jurkat Mo[1RZBweHSxc3nzJIF{e2G7 M3fBbJ4zQDBibl2= NGP6[pBFVVOR MXTpcoR2[2W|IHGgRoNtNTJvZHXw[Y5l\W62IHHwc5B1d3Orcx?= NHrVTo4yOTJ2NUSxOS=>
RIF-1 Mn3OSpVv[3Srb36gZZN{[Xl? M1\aN|Eh|rypL33s Mn;XSG1UVw>? MV;k[YNz\WG|ZYOgc5h6\2WwIHPvcpN2dXC2aX;u NV;oUod4OTJ4MUW3NVg>
RIF-1 MlLRZ5l1d3SxeHnjbZR6KGG|c3H5 NYDyVWFnOSEQvHevcYw> M1nOemROW09? NF23eVRl\WO{ZXHz[UB1dyB{MDFCtUA2LSClZXzsJJN2en[rdnHs MnTlNVI3OTV5MUi=
SVEC4-10 NXH3NVZ4TnWwY4Tpc44h[XO|YYm= MW[yNFAhdmdxbXy= MkTpSG1UVw>? NXLhXINYcW6mdXPld{BucWO{b4T1ZpVt\SCmZYDvcJlu\XKrenH0bY9v NUXxUHVVOTZ2NkexNFY>
SVEC4-10 M{X1UWZ2dmO2aX;uJIF{e2G7 NYjQcphrOjByIH7nM41t NF:0d2FFVVOR NYrRelJCcW6mdXPld{B{fHKnc4OgZYN1cW5iZnni[ZIh\m:{bXH0bY9v MmHVNVY1PjdzME[=
ARPE-19 MmLzZ5l1d3SxeHnjbZR6KGG|c3H5 MVf+NE4yKM7:Zz;tcC=> M4Hvd2ROW09? NYfYVGY6e2ixd4OgZUBld3OnLXTldIVv\GWwdDD0c5hq[2m2eR?= MXuxOlk5PzlyNR?=
ARPE-19 MkDiSpVv[3Srb36gZZN{[Xl? NH;rd2gxNjBzIN88[{9udA>? MlLRSG1UVw>? MonGbY5kemWjc3XzJHZGT0ZiYX7kJJJm\HWlZYOgVGVFTiCneIDy[ZN{cW:w NXLvTXh2OTZ7OEe5NFU>
Y-79 NHvyUYRIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MlvRglEh|rypL33s NGTCTZBFVVOR NGLae|hl\WO{ZXHz[ZMhemW2aX7vZoxie3SxbXGgZ4VtdCCycn;sbYZmemG2aX;u Mn3XNVg2Pzl5NkS=
WERI-Rb1 MVLHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NITVNo9,OSEQvHevcYw> Ml7NSG1UVw>? NUD2UWZW\GWlcnXhd4V{KHKndHnuc4Jt[XO2b33hJINmdGxicILvcIln\XKjdHnvci=> NYj4XY0{OTh3N{m3OlQ>
RB247C3 M4jnfmdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NHjRPI9,OSEQvHevcYw> M320[2ROW09? NHv6doNl\WO{ZXHz[ZMhemW2aX7vZoxie3SxbXGgZ4VtdCCycn;sbYZmemG2aX;u MVexPFU4QTd4NB?=
RB355 NHjXNoxIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NXXEfZp{hjFizsznM41t MYDEUXNQ NUX3Omxi\GWlcnXhd4V{KHKndHnuc4Jt[XO2b33hJINmdGxicILvcIln\XKjdHnvci=> NVLTU205OTh3N{m3OlQ>
RB383 MWHHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? M4jCXp4yKM7:Zz;tcC=> Mk\qSG1UVw>? NVfXWG55\GWlcnXhd4V{KHKndHnuc4Jt[XO2b33hJINmdGxicILvcIln\XKjdHnvci=> NFT3NJUyQDV5OUe2OC=>
hFibro M3nJXIN6fG:2b4jpZ4l1gSCjc4PhfS=> NF\ONlcxNjViwsXnM41t MVrEUXNQ NITVO|dl\WO{ZXHz[ZMhfmmjYnnsbZR6KGK7IEi2MFUm MX[yN|Q1OTFzNB?=
pTMC NYLWSXpG[3m2b4TvfIlkcXS7IHHzd4F6 NFK0WXMxNjViwsXnM41t NV\HXmVITE2VTx?= MXXk[YNz\WG|ZYOgeoli[mmuaYT5JIJ6KDl{Lkml NWCyelZsOjN2NEGxNVQ>
hTMC NInUbXBkgXSxdH;4bYNqfHliYYPzZZk> NGrmdoExNjViwsXnM41t MnHOSG1UVw>? NVq1OHZL\GWlcnXhd4V{KH[rYXLpcIl1gSCkeTC4PE46LQ>? NHj5[WozOzR2MUGxOC=>
ARPE-19 NEjucmtkgXSxdH;4bYNqfHliYYPzZZk> NHr3XnkxNjViwsXnM41t MYHEUXNQ M37tR4Rm[3KnYYPld{B3cWGkaXzpeJkh[nliNUWuOUU> NW\TdpRGOjN2NEGxNVQ>
Panc-1 NVXCPGd3T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NFL5O4wyOCEQvF2= MnzYSG1UVw>? MVHpcohq[mm2czDj[YxtKHC{b3zp[oVz[XSrb36= NFvJbVczPDB4OUC2PS=>
MIA PaCa-2 M1TLWWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MlnYNVAh|ryP NV\vSGUzTE2VTx?= MV\pcohq[mm2czDj[YxtKHC{b3zp[oVz[XSrb36= NWL4RYpjOjRyNkmwOlk>
BxPC-3 MmjqS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NG\1WFUyOCEQvF2= NX;5PHBlTE2VTx?= MmS3bY5pcWKrdIOgZ4VtdCCycn;sbYZmemG2aX;uJINwdXCuZYTlcJk> Mn3hNlQxPjlyNkm=
SU86.86 Ml7GS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MkC0NVAh|ryP MWrEUXNQ MYHpcohq[mm2czDj[YxtKHC{b3zp[oVz[XSrb36gZ49ueGyndHXsfS=> NEXjPWczPDB4OUC2PS=>
MCF-7 MmX1RZV1d3CqYXf5JIF{e2G7 NGfsU2IyOCEQvF2= NILkeWtFVVOR NXrwTm1kcW6qaXLpeJMh\2WvY3n0ZYJqdmVvaX7keYNm\CCjdYTvdIhi\3l? MYKyOFA3QTB4OR?=
WERI MnPvS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? M4\VZp4yOCEQvHevcYw> NXrPUpJKTE2VTx?= MkHRbY5pcWKrdIOg[5Jwf3SqIH;mJJJmfGmwb3LsZZN1d22jIHPlcIx{ MnrvNlQ5OzdzNEK=
WERI MmrOSpVv[3Srb36gZZN{[Xl? M{[2UJ4yOCEQvHevcYw> M3O4dmROW09? NXvsfJg6[myxY3vzJINmdGxiY4njcIUheHKxZ4Lld5Nqd25? M3HmTVI1QDN5MUSy
Y-79 NGXGRmxHfW6ldHnvckBie3OjeR?= MWj+NVAh|rypL33s NYizNW9uTE2VTx?= MnPjZoxw[2u|IHPlcIwh[3mlbHWgdJJw\3Knc4Ppc44> M3;sSFI1QDN5MUSy
Y-79 NWS5clFpTnWwY4Tpc44h[XO|YYm= NYnrcJBshjFyIN88[{9udA>? Mn36SG1UVw>? NUnRUXNT[W[oZXP0d{B[SVBvVFXBSEBxem:2bz3vcoNw\2WwZTDwZZRpf2G7 MVGyOFg{PzF2Mh?=
Y-79 M2\pWWZ2dmO2aX;uJIF{e2G7 Mmq2glExKM7:Zz;tcC=> MnK2SG1UVw>? MWrkc5dvNXKnZ4XsZZRmeyCybIXybZBwfGWwY4mgcYFzc2W{IF;DWE01 MUSyOFg{PzF2Mh?=

多くの細胞株試験データを見る場合、クリックしてください

体内試験 Verteporfin can be used for angiographic visualization of choroidal vessels and CNV, which demonstrates that the photosensitizer accumulates rapidly in experimental CNV in monkeys. Verteporfin accumulates rapidly in the established vasculature of the choroid, RPE, and photoreceptors of rabbit eyes. Verteporfin reaches maximal tissue levels within 3 hours of intravenous injection, followed by a rapid decline within 24 hours in mice. Verteporfin is metabolized to a less active form in vivo and is cleared very rapidly, predominantly in the feces and a very small proportion excreted in urine. Verteporfin therapy effectively and selectively prevents fluorescein dye leakage from experimentally induced CNV in monkeys. [1]

お薦めの試験操作(参考用のみ)

溶解度 (25°C)

体外 DMSO 100 mg/mL (139.12 mM)
Water Insoluble
Ethanol Insoluble

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 718.79
化学式

C41H42N4O8

CAS No. 129497-78-5
保管
別名 CL 318952

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01846273 Active, not recruiting Age-related Macular Degeneration; Polypoidal Choroidal Vasculopathy (PCV) Novartis Pharmaceuticals|Novartis August 7, 2013 Phase 4
NCT03033225 Active, not recruiting Pancreatic Cancer Non-Resectable Mayo Clinic January 2017 Phase 2
NCT02939274 Recruiting Metastatic Breast Cancer Rogers Sciences Inc. October 2016 Phase 2
NCT02702700 Recruiting Pleural Effusion, Malignant Centre Hospitalier Universitaire Vaudois January 2016 Phase 1
NCT02495181 Recruiting Polypoidal Choroidal Vasculopathy Association for Innovation and Biomedical Research on Light and Image|European Vision Institute Clinical Research Network January 2016 Phase 4
NCT02457026 Withdrawn Neovascular Age-related Macular Degeneration Duke University|Bausch & Lomb Incorporated January 2016 --

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Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

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