Z-VAD-FMK

製品コードS7023

Z-VAD-FMK化学構造

分子量(MW):467.49

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.

サイズ 価格(税別)  
JPY 19422.00
JPY 78020.00

カスタマーフィードバック(4)

  • After treatment with 1.5 g/l matrine in the presence or absence of 10 nM Baf A1 or 20 nM rapamycin or 10 lM z-VAD-FMK (zVAD) for 24 hrs, the cell viability was measured by CCK-8 assay. Results were expressed as mean±S.E.M. representing at least three independent experiments. *P < 0.05, versus matrine alone group.

    J Cell Mol Med, 2017, 21(6):1171-1181. Z-VAD-FMK purchased from Selleck.

    (A and B) Western blot analysis examining the effect of zVAD-fmk on the icaritin-induced apoptosis. The caspase inhibitor zVAD-fmk could significantly decrease the icaritin-induced cleaved caspase-3 expression. β-Actin protein levels indicate that an equal amount of protein was loaded into each lane.n=3. Mean±SD. bP<0.05, compared to the control group. eP<0.05, compared to the icaritin-treated group.

    Acta Pharmacol Sin 2014 35(4):531-9. Z-VAD-FMK purchased from Selleck.

  • Active caspase-3 expression analysis. SW1116 cells were treated with ZBH-1205, CPT-11 and SN38 at 25 μmol/L for 48 h, in the presence or absence of Z-VAD-FMK (50 μmol/L, 1 h ahead of time). *P= 0.0345. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). E: Cell cycle analysis. F: Apoptosis analysis. #P=0.0259. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). ALL experiments were repeated three times.

    Arch Biochem Biophys, 2016, 604:74-85.. Z-VAD-FMK purchased from Selleck.

    Effect on the RAS of CFZ, z-VAD-fmk, or CFZ + z-VAD-fmk treatments administered 5 or 12 days after C26 inoculation and control groups. Western blot analysis of ATF2 and pATF2. CP, ZP and UP were treated for 5 days; CT, ZT, UT and CC were treated for 12 days. CFZ (CP), z-VAD-fmk (ZP), CFZ + z-VAD-fmk (UP), PBS only (CC), healthy control (HC).

    Med Oncol, 2015, 32(4): 538 . Z-VAD-FMK purchased from Selleck.

製品安全説明書

Caspase阻害剤の選択性比較

生物活性

製品説明 Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.
特性 A key compound for apoptosis studies.
ターゲット
Pan-caspase [1]
(THP.1, Jurkat T-cells)
体外試験

Z-VAD-FMK (10 mM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK (10 mM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells. [1] Z-VAD-FMK (50 μM) cotreatment abolishes the apoptotic morphology of camptothecin-treated HL60 cells. Z-VAD-FMK (50 μM) blocks camptothecin-induced DNA fragmentation in HL60 cells. [2] Z-VAD-FMK (50 μM) inhibits cell death following dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK (50 μM) increases the percentage of transfected cells surviving from 26% to 63% in S2 cells. [3] Z-VAD-FMK (> 100 μM) enhances TNFα-induced neutrophil apoptosis, lower concentrations (1-30 μM) completely blocks TNFα-stimulated apoptosis in human neutrophils. [4] Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes. Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes detected with the TUNEL assay. [5]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
GC1a NITZbXdCeG:ydH;zbZMhSXO|YYm= NY\wO5VpPTEQvF2= M17GZ|I1cA>? M3vxT4lv\GmlYYTld{BiKHC{b4TlZ5RqfmViZX\m[YN1KGGpYXnud5Qh\XSxcH;zbYRm MWCyOlE3QTB5NR?=
HGL5 MnTORZBweHSxc3nzJGF{e2G7 NV3JPXpKPTEQvF2= M4Dxe|I1cA>? NWjIcVVCcW6maXPheIV{KGFicILveIVkfGm4ZTDl[oZm[3RiYXfhbY5{fCCndH;wc5Nq\GV? M2X6cFI3OTZ7MEe1
HepG2 NXTw[5hYSXCxcITvd4l{KEG|c3H5 NYnmTFZ[OjEQvF2= NEnBR|AycA>? NGXoOJZifHSnboXheIVlKHSqZTDhdI9xfG:2aXOgbY5lfWO2aX;uJI9nKEmLST2xNOKh M13STVI3OTZ2N{m1
BEL-7402 MmfyRZBweHSxc3nzJGF{e2G7 NEHKXIMzOM7:TR?= MVmxbC=> NU\VU|hM[XS2ZX71ZZRm\CC2aHWgZZBweHSxdHnjJIlv\HWldHnvckBw\iCLSVmtNVDDqA>? NUG5Tm1zOjZzNkS3PVU>
CEF MkPnT4lv[XOnIFHzd4F6 M2XDU|AtOzNuNkesNVAx|ryP M1rSd|E2dWmw NYnhfnFk\G:5bj3y[Yd2dGG2ZYOgVHIh\W68eX3lJIFkfGm4aYT5JJRwKDRy78{FJIF1KDFyMN88US=> NVrRb4FGOjZzMEKzN|k>
SP2/0 NWfOOow3SXCxcITvd4l{KEG|c3H5 NVLvXplQOTByzszN NHPLSXkycA>? M2XrNWROW09? MmLXZoxw[2u|IITo[UBieG:ydH;zbZMhd2ZiU2CyM|Ah[2WubIO= MorRNlYxPzR5M{K=
HUVEC-2c NYjp[YVNSXCxcITvd4l{KEG|c3H5 MVm1NO69VQ>? MV[2bC=> M13lb4Rm[3KnYYPl[EB1cGVib4itUGRNNWmwZIXj[YQh[XW2b4DoZYd6 NGHVN4EzPjB{MUeyPS=>
U1 MmnRRZBweHSxc3nzJGF{e2G7 MmjuNE0yODEQvF2= NFjacGQzcA>? NVXzcIs3emWmdXPld{BlenWpLXnu[JVk\WRiYYDvdJRwe2m|IHHu[EB{fWK|ZYH1[Y51KEiLVj2xJJJmeGyrY3H0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz M4jDZlI2QThyOUSy
ACH-2 NEfucoFCeG:ydH;zbZMhSXO|YYm= NWS3eYZFOC1{MEFOwG0> NVu1d29MOmh? NWG0ZohnemWmdXPld{BlenWpLXnu[JVk\WRiYYDvdJRwe2m|IHHu[EB{fWK|ZYH1[Y51KEiLVj2xJJJmeGyrY3H0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz NXfF[GltOjV7OEC5OFI>
U1 NUHRS4REU2mwYYPlJGF{e2G7 MXqxNFDPxE1? NVnnbpBjOmh? NHnT[mVqdmirYnn0d{Bk[XOyYYPlMVM> NXvI[FluOjV7OEC5OFI>
A549/V16 M3rONWFxd3C2b4Ppd{BCe3OjeR?= NUThVpB5PTEQvF2= M4TNWlFp NVzze5pUemWycnXzd4V{KFSJL2TNMYlv\HWlZXSgZZBweHSxc3nz MX2yOVk1PjB|Mx?=
SGN NV;3Ood{SXCxcITvd4l{KEG|c3H5 MXGyNI1O NE\mcXI1QGh? NEXpbG9p[XNibn:gbY5ndHWnbnPlJI9vKEGLRjygZ4FteGGrbjDlfJBz\XO|aX;uJI9zKGOnbHygZZBweHSxc3nz NWLjb|BROjV6N{S2N|M>
HCT116  NVfjeolvSXCxcITvd4l{KEG|c3H5 MofROVDPxE1? MoXpNog> NV7BNXFmcW6qaXLpeJMhfGinIHPlcIwh\GWjdHigbY5lfWOnZDDifUBFTF[S NI\QVGEzPTh4OEixPC=>
DTK-SME MYXBdI9xfG:|aYOgRZN{[Xl? MoHTOVDPxE1? M2TGTFJp M{PtfWROW09? MlP4dIFzfGmjbHz5JIlvcGmkaYTzJJRp\SCjcH;weI9{cXNiaX7keYNm\CCkeTDieZBqfmGlYXnu[S=> MWmyOVg1Ozh7Nx?=
HL-60 M16wdmFxd3C2b4Ppd{BCe3OjeR?= NIDXN2g2OM7:TR?= MXG0PIg> NFuxcYJz\WS3Y3XzJINmdGxiZHXheIgh[2G3c3XkJIJ6KFONST3JTUB1emWjdH3lcpTDqA>? NG\5[WQzPTh{NEC0Ny=>
U937 MlHPRZBweHSxc3nzJGF{e2G7 NULnSIhmPTEQvF2= MVK0PIg> MojEdoVlfWOnczDj[YxtKGSnYYToJINifXOnZDDifUBUU0lvSVmgeJJm[XSvZX70xsA> MlH4NlU5OjRyNEO=
A549 NETO[ppCeG:ydH;zbZMhSXO|YYm= NFW0W|AzOCEQvF2= M4HvV|I1cA>? NGLPWFhz\WS3Y3XzJINmdGxiZHXheIgh[2G3c3XkJIJ6KEiIQ2CgeJJm[XSvZX70 NHH1c5AzPTd7NEG0PS=>
HeLa NU\vTlgySXCxcITvd4l{KEG|c3H5 NFrs[FEyOM7:TR?= MVm0PIg> MXXk[YNtcW6nczD0bIUhemG2ZTDv[kBieG:ydH;zbZMh\HKjbXH0bYNidGy7 MX:yOVc4OjV2NR?=
SGC-7901 MlzmRZBweHSxc3nzJGF{e2G7 MWqyNOKh|ryP M{DFSVFp MV\pcohq[mm2czD0bIUh[2WubDDk[YF1cCCrbnT1Z4VlKGK7IH;4ZYxqeGyjdHnu M4r5XVI2PzZ5MEe2
MCF-7 MnnhRZBweHSxc3nzJGF{e2G7 M1LYdVEx|ryP NGO5[2IzcA>? MXnpcohq[mm2czD0bIUh[2WubDDk[YF1cCCrbnT1Z4VlKGK7IEPC M175eFI2PzJ{MUG0
A549 NFvxOGxCeG:ydH;zbZMhSXO|YYm= NGLFUJEyOCEQvF2= NGD1NGQzPGh? MX7EUXNQ MV3wdo9ud3SnczDIRmMufHKnYYTl[EBCPTR7IHPlcIwhe3W{dnn2ZYwhLiCjdITlcpVifGW|IITo[UBkdGWjdnXkJHBCWlBiZYjwdoV{e2mxbh?= MmfxNlU3QDN3Nki=
U87 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXy1NO69VQ>? NFLvdZAycA>? MlHFdoVkd3[ncoOgZ4VtdCCpcn;3eIgh\nKxbTDUUXohfHKnYYTt[Y51 M{T5OVI2PjhzNk[4
Neocortical Neuron M3u5T25mfXKxdH;4bYNqfHliQYPzZZk> MojUNVAx|ryP MkfwNYg> NYDsUmQ1[W62YXfvcol7\XNiSH;pZY1q\GViQT3JcoR2[2WmIF7leZJwfG:6aXPpeJk> MWiyOVY4PTByMR?=
Primary human placental cytotrophoblasts MX7BdI9xfG:|aYOgRZN{[Xl? MUCzNO69VQ>? NWjSOmdXOjSq M{HOe2ROW09? M3;4dZJmfmW{c3XzJJRp\SCrbnjpZol1cW:wIH;mJFEy|rJvSGPENkBjgSC2cnnjcI9{[W8EoB?= MlzHNlU3PDJ3OUK=
MM NEDQeopCeG:ydH;zbZMhSXO|YYm= MoXPOVDPxE1? NUTXe2h3OjCvaX6= M4X0bZBienSueTDpcohq[mm2czDTTGsucW6mdXPl[EAh[2WubDDk[YF1cA>? MUmyOVU{ODB7OB?=
DLD1 NWHaTVhzSXCxcITvd4l{KEG|c3H5 MoHQNlDDqM7:TR?= MXuxbC=> MoXndIFzfGy7IILleoVze2W|IHPlcIwh[XCxcITvd4l{KGOjdYPl[EBjgSCZU2Cx NYXWSpJFOjV3MkSyOFY>
MDA-MB-231 NUmzW|JES3m2b4TvfIlkcXS7IFHzd4F6 M1rRZ|Ex|ryP NHnvdoMycA>? M3H5d4F2\22nboTzJINmdGxiZHXheIgh[W[2ZYKgR2hWSSC2cnXheI1mdnR? M{X3dlI2PTJzNUCx
MKN28 NXPhcnJKSXCxcITvd4l{KEG|c3H5 NULpNpdJOTEQvF2= M3nBbFMxdWmw MmXHSG1UVw>? NGPRW41qdmirYnn0d{BVVkZvzsGgdIx2eyCFSGitbY5lfWOnZDDhdI9xfG:|aYO= NUPv[oY6OjV3MUO5OlA>
HL-60 NYTSdpRQS3m2b4TvfIlkcXS7IFHzd4F6 MkjNNVAx|ryP MXuxbC=> M1;jdWROW09? Mk[3xsBqdXC{b4\ld{B3cWGkaXzpeJkhd2ZiVFPORZMufHKnYYTl[EBk\Wyucx?= NV7pNWhbOjV3MEK5N|I>
AGS M1nFbWFxd3C2b4Ppd{BCe3OjeR?= NHvDTW0yOM7:TR?= M13GUlFp NV;hdGtUeHKndnXueJMh[3W{Y4XtbY4ucW6mdXPl[EBkdGWjdnHn[UBw\iClYYPwZZNmNTNuID24MEBidmRiLUmgdJJwfGWrboO= MoXGNlU1QTJ{MUS=
A549  MkfYRZBweHSxc3nzJGF{e2G7 MXixNO69VQ>? MV2yOIg> M3fCOYJtd2OtczDEUWFUNWmwZIXj[YQh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|IHHu[EBRSVKSIHHu[EBieG:ydH;0bYMh[2WubDDk[YF1cA>? NY\le2xJOjV2M{S5PFk>
INS-1 M2jBSGFxd3C2b4Ppd{BCe3OjeR?= MoTiOVDPxE1? M1ywRVZp M1v6bWROW09? MUDk[YNz\WG|ZYOgeIhmKHC{b4DvdpRqd25ib3[g[YFzdHliYYDvdJRwfGmlIHPlcIx{yqB? Mk\HNlU1OzB6OUe=
Primary hepatocytes  M4HvfWFxd3C2b4Ppd{BCe3OjeR?= NWHPeFVSPTEQvF2= NH\zUG8yQGh? NVrYUmkycW6qaXLpeJMh[XCxcITvd4l{KG:oIHjldIF1d2O7dHXzJIlv\HWlZXSgZpkhSWO2IFSgZY5lKFSQRj5OtS=> MWSyOVQxPzV|OB?=
L929-A  NXTJfXFpS3m2b4TvfIlkcXS7IFHzd4F6 M{CzSFIxyqEQvF2= NFfCWGozPGh? NHLwXVJqdmirYnn0d{BVVkcQsT3pcoR2[2WmIHPlcIwh\GWjdHi= MYSyOVM6QDV2MB?=
L929-N MWnDfZRwfG:6aXPpeJkhSXO|YYm= Ml\3NlDDqM7:TR?= MknrNlRp NGnyNJNmdmijbnPld{Bl\WG2aDD2bYEh[XW2b3PybY5mKFSQRt8xJJBzd2S3Y4Tpc44> MYWyOVM6QDV2MB?=
Cytotoxicity Assay MV\D[YxtKF[rYXLpcIl1gSCDc4PhfS=> NE[5N2gzOM7:TR?= MYi0PIg> MWfwdoV3\W62IF3IUWQucW6mdXPl[EBk\WyuIHTlZZRp NGG1UYQzPTN7MkGxOi=>
COS7 NYPqOppXU2mwYYPlJGF{e2G7 NUHyPFREOTEQvF2= M1LTe|I1cA>? MlzkbY5kemWjc3XzJINie3Cjc3WgN{84KGGldHn2bZRq\XN? NYXVd29JOjV|OESwNlU>
COS7 MXnBdI9xfG:|aYOgRZN{[Xl? M4DlZVEx|ryP M4HVSFQ5cA>? NEDFTFBx[XK2aXHscJkheHKndnXueIVlKE[FMUCxMYlv\HWlZXSgZ4VtdCCmZXH0bC=> M171V|I2Ozh2MEK1
A375 MWXBdI9xfG:|aYOgRZN{[Xl? NEX0Wlk{OM7:TR?= NWTwT2d{Omh? MX7wdoV3\W62czD0bIUh\HK3Zz3pcoR2[2WmIGDBVnAh[2ynYY\h[4U> NF[3WWkzPTN5NkGxOS=>
A549 NFT6dZZCeG:ydH;zbZMhSXO|YYm= NG\4WoI2OM7:TR?= M1vEb|I1cA>? MYDy[ZZmenOnczDybYJwe2:vZTDibY9o\W6nc3nzJIFv\CCjcH;weI9{cXNiY3H1d4VlKGK7IDDDbIlrd26pZHHu NHH1UJAzPTN2OUe4NS=>
A549 NEDwXnRCeG:ydH;zbZMhSXO|YYm= M3TDXFIvPS1{Nd88US=> MW[xbC=> NG\wRo5l\WO{ZXHz[ZMhfGinIIDvdJVt[XSrb36gc4Yh[XCxcITveIlkKGOnbHzzJIRmeGWwZDDvckBkd26lZX70doF1cW:wcx?= MVuyOVM1OjR{Nx?=
 NBL-W-S  NVT0OWVDSXCxcITvd4l{KEG|c3H5 NXf6VFBbPTEQvF2= NVjGZ244OWh? M4HTXIZ2dGy7IILld4N2\XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgS2FPXC14MTD0doVifG2nboS= NWDjR4d7OjV|MkOyNlI>
Caki-1  MYDBdI9xfG:|aYOgRZN{[Xl? Ml\FOFDPxE1? NUSydm9YPDiq Mk\WdoVlfWOnczD0bIUhdnWvYnXyJI9nKEGwbnX4bY4hXi2yb4PpeIl3\SClZXzsdy=> M1LYclI2Ojd7MUmx
769-P MlnORZBweHSxc3nzJGF{e2G7 M1e0fFQx|ryP NUXUc4tIPDiq NXzqU3ZzemWmdXPld{B1cGViboXtZoVzKG:oIFHucoV5cW5iVj3wc5NqfGm4ZTDj[Yxtew>? NHnWTnEzPTJ5OUG5NS=>
H9c2 MnvORZBweHSxc3nzJGF{e2G7 M4PoPFUx|ryP M2fsdlFp NGHZSYNqdmirYnn0d{BFV1hvaX7keYNm\CClYYPwZZNmKDNiYXP0bZZifGmxbjDieZQhdm:2IITo[UBtd3O|IH;mJINmdGy| NV7pXVl5OjV{OEO4NVk>
K562 NEW5XIVCeG:ydH;zbZMhSXO|YYm= M4jEdFUx|ryP M4TnUlRp NHjzd4dqdmirYnn0d{BL[WNvQT3pcoR2[2WmIHPlcIwh[XCxcITvd4l{ MWiyOVI1OTZzOR?=
L929 MV\BdI9xfG:|aYOgRZN{[Xl? MXexNO69VQ>? NYG1O5AxPmh? NELtW4xqdmS3Y3XzJI5m[3KxcITvd4l{KHerdHigWG5H MnXrNlUyQTV4NkC=
A549 NF7MRWFCeG:ydH;zbZMhSXO|YYm= MWmxNO69VQ>? MVezbC=> MYjy[YR2[2W|IHPlcIwh[XCxcITvd4l{KGOjdYPl[EBjgSCSUWG= MXuyOVE3OTZ7OR?=
MCF-7 NX:wdXljSXCxcITvd4l{KEG|c3H5 NVHKOVNpOjEQvF2= M2W0OFJp NHjLWVdl\WO{ZXHz[ZMhU0SULYPpVm5CNWmwZIXj[YQh[XCxcITvd4l{ M4G2NVI2OTh{MkSw
OS MYDBdI9xfG:|aYOgRZN{[Xl? NVy4OGluOjBxNEFOwG0> NXOwPXBSPzKq NXnyUmMzcW6qaXLpeJMhV1NiY3XscEB3cWGkaXzpeJkhemWmdXP0bY9vKGK7IFO2JINmemGvaXTl MX:yOVE2OjN7OR?=
HUVECs MWDBdI9xfG:|aYOgRZN{[Xl? MVKxNO69VQ>? MV2ybC=> MkjWxsBqdmirYnn0d{BieG:ydH;zbZMh[W6mIH\hZ4ltcXSjdHXzJIF2fG:yaHHnfUBqdiCGRV7WNk1qdm[nY4Tl[EBJXV[HQ4O= NGKzc5czPTF|OEewNy=>
EA.hy926 MnjsRZBweHSxc3nzJGF{e2G7 MUixNO69VQ>? MljnNog> MWVCpIlvcGmkaYTzJIFxd3C2b4Ppd{BidmRiZnHjbYxqfGG2ZYOgZZV1d3CqYXf5JIlvKESHTm[yMYlv\mWldHXkJGVCNmi7OUK2 M{D4SlI2OTN6N{Cz
Ebs MXTBdI9xfG:|aYOgRZN{[Xl? MUCxNE0yODEQvF2= M2KwRVI1cA>? M1rDS:KhVU2WUzDn[Y5memG2aX;uJJJifGViZHXjdoVie2WmIHHzJJRp\SClb37j[Y51emG2aX;uJI9nKHpvVlHEMoZucyCrbnPy[YF{\WR? NYfucpIzOjVzM{S4NVc>
Jurkat Mn\oRZBweHSxc3nzJGF{e2G7 NV7mOGNWOjEQvF2= NIPZSHMzPGh? NVHoUYdkTE2VTx?= M4Ky[JBienSrYXzsfUBqdmirYnn0JINmdGxiZHXheIghd2ZiSoXyb4F1KGOnbHzzJIlv\HWlZXSgZpkhOTByNUitSlQh[2:vYnnu[YQhf2m2aDDWVGHDqA>? NEXHWJEzPTF{MEeyNy=>
K562 MkL4RZBweHSxc3nzJGF{e2G7 MXmwMlEuOc7:TR?= NHjsboEycA>? NYS3cppDcW6qaXLpeJMh[2ynYY\h[4Uhd2ZiSGPQPVAhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> MYOyOVEyQTF6OB?=
IMR-32 MlHvRZBweHSxc3nzJGF{e2G7 NUXvSoVvPDEEoN88UeKh NY\DNZFPOmh? MX;k[YNz\WG|ZTDpckBieG:ydH;0bYMh[2WubIOgZ49ueGG{ZXSgeI8hXC1{IITvfIlv NYrGSXBzOjVyOES3OVU>
RPMI 8226 NXTyVnZpSXCxcITvd4l{KEG|c3H5 Mlq0NVAx|ryP M4qzWVFp M4X1S4FtdW:|dDDjc41xdGW2ZXz5JIJtd2OtczDj[YxtKGSnYYToJINifXOnZDDifUBv\WO{b4P0ZZRqdi1z Ml7XNlUxOzd6NUG=
U266  M4SxfGFxd3C2b4Ppd{BCe3OjeR?= NVWzWY5bOTByzszN NYiwOoRnOWh? Ml3tdIFzfGmjbHz5JIJtd2OtczDj[YxtKGSnYYToJINifXOnZDDifUBv\WO{b4P0ZZRqdi1z MoPzNlUxOzd6NUG=
H929  NF3sNFBCeG:ydH;zbZMhSXO|YYm= NWPlTHR[OTByzszN NF3rbWEycA>? MXTwZZJ1cWGubImgZoxw[2u|IHPlcIwh\GWjdHigZ4F2e2WmIHL5JI5m[3Kxc4TheIlvNTF? M1nk[VI2ODN5OEWx
MM.1S  M1HpXWFxd3C2b4Ppd{BCe3OjeR?= MnPpNVAx|ryP NGTn[FgycA>? NFT4TGlm\m[rY3nlcpRtgSCycnX2[Y51eyC|b4Lh[oVvcWJvaX7keYNm\CClZXzsJIRm[XSqIHPvcYJqdmVid3n0bEBv\WO{b4P0ZZRqdi1z MVyyOVA{Pzh3MR?=
C6 M{D1eWFxd3C2b4Ppd{BCe3OjeR?= MUW1NO69VQ>? MnzIOFhp MX7wdoV3\W62czD0bIUhdG:|czDv[kBk\WyuII\pZYJqdGm2eTDjZZV{\WRiYomgdJJm\26nbn;sc45m MWqyOVAyOzR5OR?=
AGS NYXjO4JMSXCxcITvd4l{KEG|c3H5 NVLuXVhlPTEQvF2= MlTpNlRp M1HjcIFjd2yrc3jzJO6zNWyjcHHjbI9v\S2rbnT1Z4VlKGOnbHyg[IVifGhiYX7kJIlvcGmkaYTl[EBoem:5dHi= NIqwOIMzPTByOU[5PC=>
HeLa  MWDBdI9xfG:|aYOgRZN{[Xl? Mn;VOFDPxE1? M4TTWFI1cA>? NIfUdWZqdmirYnn0d{B1cGViaX7jdoVie2WmIHHwc5B1d3OrczDpcoR2[2WmIHL5JJNqWk6IMUKx NYG5cpVFOjR7Mki2PFU>
THP-1  MoPSRZBweHSxc3nzJGF{e2G7 M2PhOlEx|ryP M2XkOlFp Ml;pdoVlfWOnczDhdI9xfG:|aYOgbY5lfWOnZDDifUBCVEFvU1TUxsA> NUf6V3pxOjR7MkO2OVM>
P815  MnfRRZBweHSxc3nzJGF{e2G7 NWm1SllbOTByINM1US=> NUTBXGJSOTKq NXXNVnA2TE2VTx?= MVzpcohq[mm2czD2bZJ2ey2rbnT1Z4VlKGGyb4D0c5Nqew>? NI\1fGQzPDl{M{K3Ny=>
HCT116 NX;RT4p{SXCxcITvd4l{KEG|c3H5 M{noTlIx|ryP M3LPPFI1cA>? MmLQZYJzd2ejdHXzJI9nKFSTLXnu[JVk\WRiYYDvdJRwe2l? NXPrVYIyOjR6OUC0OFk>
SW1116  NFT4d2NCeG:ydH;zbZMhSXO|YYm= MkLFNVAhyrWP MYWxbC=> NF;GToJFVVOR MWry[ZN1emGrboOgZ4VtdCCjcH;weI9{cXNiaX7keYNm\CCkeTDn[YZqfGmwaXKgdIx2eyCmZXPpeIFjcW6n M1TxSlI1QDd2Mki2
LOVO M4XyXmFxd3C2b4Ppd{BCe3OjeR?= MkTJNVAhyrWP NVOzSWZIOWh? NWn4SlN[TE2VTx?= MWXy[ZN1emGrboOgZ4VtdCCjcH;weI9{cXNiaX7keYNm\CCkeTDn[YZqfGmwaXKgdIx2eyCmZXPpeIFjcW6n MVSyOFg4PDJ6Nh?=
SNU449  M1rJ[WFxd3C2b4Ppd{BCe3OjeR?= NIDocHAzOM7:TR?= M1;OSFQ5cA>? NHXXdJBFVVOR M2TaXYRm[3KnYYPld{BucVJvNEWxMYlv\HWlZXSgZZBweHSxdHnj M{DvRlI1QDRzNkO4
Caco-2 MlX5RZBweHSxc3nzJGF{e2G7 NIDNTlY1OOLCid88US=> NHjIcFY1cA>? M4GzfJBz\X[nboTzJHNVNTdvaX7keYNm\CCcTz2xJINp[W6pZYOgZY5lKFSHUjDkdo9x M{D0S|I1QDJ{MUiz
macrophage NUf6RoYyS2WubDDWbYFjcWyrdImgRZN{[Xl? MkP6NE0zODEQvF2= MlvmNlRp NF\rTYtqdmS3Y3XzJHRPTi1iYX7kJHJqeDNvZHXw[Y5l\W62IH7lZ5JweHSxc3nzJIlvKG2jY4LvdIhi\2V? MoHZNlQ4QTl3NkW=
AGS  MX3BdI9xfG:|aYOgRZN{[Xl? MWOyNO69VQ>? MkK5NVJp MYLEUXNQ M2H0bJJm\HWlZYOgeIhmKGmwZIXjeIlwdiCxZjDhdI9xfG:|aYOgbY4hemW|cH;ud4UhfG9idHjlJGV1V0GlIH\yZYN1cW:wIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ NXf5R4E5OjR5OEm3NFM>
LCC9  M4\CR2NmdGxiVnnhZoltcXS7IFHzd4F6 M2TTT|ExOM7:TR?= MYS1[C=> NEnxTlJjdG:la4OgZ4VtdCCmZXH0bEBqdmS3Y3XkJIJ6KGOxbXLpcoF1cW:wIFyxO{BidmRiY3jsc5JweXWrbnW= MlL5NlQ4QDV{NU[=
U937  NInCTIpv\WO{b4D0c5NqeyCDc4PhfS=> MWKxNOKh|ryP NFrBc5o{OMLibXnu NF3aVlVqdmS3Y3XzJI5m[3KxcITvd4l{KGOxbXLpcoUhf2m2aDDUUmY> NEGzSm8zPDd5M{e1Oi=>
T cell MoKzR4VtdCCycn;sbYZmemG2aX;uJIF{e2G7 NHHZbIUxNTFyMN88US=> MnKzO|Jp M4fjcGlEPTB;N{Cg{txONCCrbnjpZol1eyCjboTpMWNFOy2rbnT1Z4VlKFRiY3XscEBxem:uaX\ldoF1cW:wIHnuJHBDVUO| MlP5NlQ4Pjh5MEe=
HeLa  MX\BdI9xfG:|aYOgRZN{[Xl? M3;LT|Ux|ryP MnP6O|Jp NGrWSVZFVVOR M3TQSJBz\X[nboTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KGOxbYDveY5le8LiMfMAl|U> MYSyOFc2PDd6Nh?=
HeLa  MUjBdI9xfG:|aYOgRZN{[Xl? NFixd4cyODEQvF2= MmL1NlRp Mmq1d5VxeHKnc4Pld{Bz[XSnIH;mJINmdGxiZHXheIghcW6mdXPl[EBjgSCxdnXy[ZhxemW|c3nvckBw\iCJNUnTJI9zKEd5MWKgdFE2OGeudXXkxsA> NFOyc24zPDd{MkS2PC=>
IEC-6  MlnvRZBweHSxc3nzJGF{e2G7 NWHmSm13OTEQvF2= M4LjUlI1cA>? NFXxPIVxemW4ZX70d{BV[2SDLXnu[JVk\WRiY3HzdIF{\S1|IHPs[YF3[WenIHHu[EDPui2lYYTlcolvKGSnZ4Lh[IF1cW:w MYSyOFcyOTV5MR?=
HCT116 MUjBdI9xfG:|aYOgRZN{[Xl? NITBZoUzOM7:TR?= NYW3UWl1OjSq NYrDXFJScW6qaXLpeJMhfGinIHPlcIwh[XCxcITveIlkKGmwZIXj[YQh[nliWVzUNlA2 M1;sUlI1PzF|OEGy
L02 NUjRPW9jSXCxcITvd4l{KEG|c3H5 MV[yNO69VQ>? MWqxbC=> MknqdJJmfmWwdIOgeIhmKGOnbHygZZBweHSxc3nzJIlv\HWlZXSgZpkhVUWKUB?= NXLoc|F3OjR5ME[0OlE>
A375 MXzBdI9xfG:|aYOgRZN{[Xl? NWe3SHZwOjEQvF2= MmLUNlRp M1PFe5JmfmW{c3XzJIRq[2m2cnnuc45mKEJvaX7keYNm\CCjcH;weI9{cXN? M1X3XFI1Pjl7MUGx
HDPC M4DJbmFxd3C2b4Ppd{BCe3OjeR?= NXGzVIFxPTEEtV2= MUOyOIg> MWXpcohq[mm2czDOU{1qdmS3Y3XkJIFxd3C2b4Ppdy=> NVXoVZVpOjR4M{S1PVM>
A549 MlXCRZBweHSxc3nzJGF{e2G7 NHLGfGc2OML3TR?= NWjpVlRQOmh? MkjGSG1UVw>? M1jDW5Bz\X[nboTzJJRp\SCqeYDv[IlxdG:rZDDEUmEh[2:wdHXueEBxcGG|ZTDpcoR2[2WmIHL5JINmeGijbH;jbJJwdWmw M1zrWlI1PTh6MUO1
 BV-2 NWr2Vpk3SXCxcITvd4l{KEG|c3H5 MVWyNO69VQ>? NVX0OY5EOmh? MYnzeZBxemW|c3XzJHVXNWmwZIXj[YQh[2i{b33heIlvKGW6dIL1d4lwdiCjbnSg[Ilt[XSrb36gc4YhfGinIH71Z4xm[XJiZX72[YxweGV? NUK0SJZ6OjR3NUixNVg>
HT-29  MV3BdI9xfG:|aYOgRZN{[Xl? Mn:1OVDPxE1? NWnudZNPPDiq MmfOZoxw[2u|IITo[UBieG:ydH;zbZMhcW6mdXPl[EBjgSCtYXXtdIZmem:u MmH4NlQ2PDlzN{W=
A549 MXfBdI9xfG:|aYOgRZN{[Xl? Mn\WOe69VQ>? MX:yOIg> MnTrd5VxeHKnc4Pld{A3\cLiKFLLNVAxPDBrLXnu[JVk\WRiYYDvdJRwe2m|wrC= NXvxeWZMOjR3Mkm4O|E>
MIA-PaCa-2 NYLLdoJ5SXCxcITvd4l{KEG|c3H5 NGX4dHkzPGh? M3nKVIJtd2OtczDjcIVifmGpZTDv[kBk[XOyYYPlMVMhcW6mdXPl[EBjgSCkb4ToJGEuPDR|NkW0JIFv\CCyYXPsbZRigGWu MmDNNlQ2OTB7OUK=
Caki-1 NXy0RoluSXCxcITvd4l{KEG|c3H5 MmXNNlDPxE1? M1naWlFp M3vlTIlvcGmkaYTzJHNEWC2rbnT1Z4VlKGGyb4D0c5Nqew>? MnrBNlQ2ODR4OEG=
CLL NVfqZXFVSXCxcITvd4l{KEG|c3H5 M2HmRlI2|ryP MoD0NYg> M3\zZZBienSrYXzsfUBjdG:la4OgUWxPOjJ|OD3pcoR2[2WmIHPlcIwh[XCxcITvd4l{ NH7mWnUzPDR4N{[zOC=>
SGC-7901 NWi0N2tJSXCxcITvd4l{KEG|c3H5 M3ro[|Ex|ryP NVSzb4JnOjSq MlvBdJJwdW:2ZYOgeIhmKEOJSVmtbY5pcWKrdHXkJINmdGxiZ4Lve5RpKGmwIGPHR{04QTBzIHPlcIx{ NFPFVlgzPDR3NES4PC=>
k1735 MUTBdI9xfG:|aYOgRZN{[Xl? MWGyNQKBkc7:bR?= NXfCVnBZPGh? MkXQbY5pcWKrdIRCpHNidG2xbnXscIEucW6mdXPl[EBieG:ydH;zbZM> NYTPO5VROjR2NUGxNVY>
HaCaT  NIe4PYxCeG:ydH;zbZMhSXO|YYm= MYKxNFDPxE1? Ml3zNYg> NFztelRjdHWwdIOgWXZDNWmwZIXj[YQh[XCxcITvd4l{KGmwIFjhR4FVKGOnbHzz NXfGNWE4OjR|NU[5PVc>
podocytes M{PCeGFxd3C2b4Ppd{BCe3OjeR?= MVqyNFDPxE1? NEP6SII3cA>? MoHnbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkhOyx2LVTHSS=> MVKyOFM{Pzd5Nx?=
 KB Mlu0RZBweHSxc3nzJGF{e2G7 NHrZWWM2OM7:TR?= M{PQVFI1cA>? NUXhcmpLcW6qaXLpeJMhVGmlbz3BMYlv\HWlZXSgZ4F{eGG|ZT2zJIFv\CCSQWLQJIFkfGm4YYTpc44> NUHHWnNFOjR|M{e0PVI>
 HepG2  M4\3V2Fxd3C2b4Ppd{BCe3OjeR?= MXqxNO69VQ>? MYGyOIg> MnnOdoVlfWOnczD2bY1mdnSrbjDjcIVifmGpZTDjZZV{\WRiYomgUHBU M{XFTFI1OzJ3OEG2
fetal rat lung fibroblasts  MUjLbY5ie2ViQYPzZZk> M4PqUFgx|ryPwrC= MVGxbC=> NXr6XHNXcW6qaXLpeJMhS2G|cHHz[U0{KGGldHn2bZR6yqB? MXuyOFMyPDF|NR?=
PDL fibroblasts M1\Xc2tqdmG|ZTDBd5NigQ>? M17lblgx|ryPwrC= M3[zWVFp NFSwSZVqdmirYnn0d{BE[XOyYYPlMVMh[WO2aY\peJnDqA>? M1HJV|I1OzF2MUO1
MB49 NVi4bZliSXCxcITvd4l{KEG|c3H5 MkTINlDPxE1? NHjoW3AycA>? MWjy[ZZmenOnczDDUU1qdmS3Y3XkJINmdGxiZHXheIg> MmPONlQzQDJ2M{O=
5637 Mlz4RZBweHSxc3nzJGF{e2G7 NFvBU5UzOM7:TR?= NGLxZo0ycA>? M1Xie5JmfmW{c3XzJGNONWmwZIXj[YQh[2WubDDk[YF1cA>? MoDtNlQzQDJ2M{O=
A549  MmP3RZBweHSxc3nzJGF{e2G7 MlznNVAx|ryP MYq0PIg> NFjOd5R{fXCycnXzd4V{KHSqZTDhdI9xfG:|aYOgZ4F2e2WmIHL5JJBqeGW{aX7lxsA> M3HXNlI1Ojd{MkCx
MCC-2 MXnBdI9xfG:|aYOgRZN{[Xl? MlnQNlAh|ryP NVTNTVY3Pmh? MWrEUXNQ Mlj0Zoxw[2u|IHnu[JVk\WRiYomgd5RifXKxc4Dvdolv\SCjcH;weI9{cXNiY3XscEBl\WG2aB?= M1TQPVI1OjZ{NkW4
ADF NULveVlSSXCxcITvd4l{KEG|c3H5 MUK0NO69VQ>? NWnSSZZwPmh? MW\pcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkcGWvb4To[ZJieHlicHz1d{BbdkOuMh?= MWWyOFIzQDJ|Mh?=
 U373  NWLySVh{SXCxcITvd4l{KEG|c3H5 NF:3ZnY1OM7:TR?= MnP1Oog> NIrnZ4ZqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSClaHXtc5Rp\XKjcImgdIx2eyCcblPsNi=> MonVNlQzOjh{M{K=
RKO-HIPK2i M2XTfmFxd3C2b4Ppd{BCe3OjeR?= MoDGOFDPxE1? MkjsOog> MVzpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkcGWvb4To[ZJieHlicHz1d{BbdkOuMh?= MkLzNlQzOjh{M{K=
HEC-1B M{\hWGFxd3C2b4Ppd{BCe3OjeR?= NIjyd4EzOM7:TR?= MnXFNYg> M3HpW5Jm\HWlZYOgWHAucW6mdXPl[EBieG:ydH;zbZPDqGOjc4Dhd4UuOyCjbnSgZ4F{eGG|ZT25 MmLvNlQzOTN|NUi=
4T1 MXTD[YxtKF[rYXLpcIl1gSCDc4PhfS=> M1vtT|IvPS1zMN88US=> NGPHWHk1cA>? MY\EUXNQ MVPy[ZNkfWW|IITo[UBkgXSxdH;4bYNqfHlib3[gOHQyKGOnbHzzJIlv\HWlZXSgZpkhW1CGVDDpckBiKGOxbnPlcpRz[XSrb36g[IVx\W6mZX70JI1idm6nch?= M{DNTVI1OjB4MU[x
OS  NUTpRXdLSXCxcITvd4l{KEG|c3H5 NYfOe4hROjEQvF2= M4qxPFRp NXnCPWVTcW6qaXLpeJMhfGinIHPlcIwh\GWjdHigZ4F2e2WmIHL5JHBFXA>? MYmyOFIxPDl|Nx?=
RPE NHLFRY5CeG:ydH;zbZMhSXO|YYm= NYLwSmliOTByzszN M1XuZlQ5cA>? MWPwZZJ1cWGubImgbY5pcWKrdIOgeIhmKGOjbIDhbY4uOSCjbnSgMVIh[WO2aY\heIlwdiCjczD3[YxtKGG|IITo[UBk[XOyYYPlJIFkfGm4YYTpc44> NXLsT|NbOjR{MEKwOVI>
UD29a MYfBdI9xfG:|aYOgRZN{[Xl? M3eyNFUx|ryP MYGyOIg> NGL2W5NqdmirYnn0d{B1cGViY3XscEBl\WG2aDDjZZV{\WRiYomgUnVVOw>? Mlu0NlQyQTB3N{S=
SH-SY5Y  NETQOIpCeG:ydH;zbZMhSXO|YYm= NVnjSm9uOTEQvF2= NGDwXXMzPGh? MmnxZZR1\W63YYTld{Bk[XOyYYPlJIFkfGm4YYTpc44h[W6mIHPlcIwh\GWjdHigbY5lfWOnZDDifUBJVkVvMlTH NYrIWGt6OjRzNEW0OlM>
HeLa  MYfBdI9xfG:|aYOgRZN{[Xl? NFm3NG8yOC9{MN88US=> M13YRlI1cA>? M33OfYlvcGmkaYTzJJRp\SCjY4Tpeol1gSCxZjD0bIUhdWGsb4LpeJkhd2ZidHjlJI1mdWKncoOgc4YhfGinIHPhd5Bie2VvZnHtbYx6 M{nEN|I1OTN5Mk[2
SCCVII  M3rkPGFxd3C2b4Ppd{BCe3OjeR?= NInVUmUzPc7:TR?= MlvLNYg> NEHyd5RqdmirYnn0d{B1cGViY3XscEBscWyuaX7nJIFnfGW{IHThd4F1cW6rYh?= NVzHO2pDOjRzMk[0OlQ>
RAW 264.7 MVzBdI9xfG:|aYOgRZN{[Xl? MUiyNO69VQ>? M1SxNlE5cA>? MXLpcoNz\WG|ZYOgUGM{NUmLL98yMYFkfGmwIILheIlwKGOxbYDhdoVlKHSxIFXDWHYuVU:VIITy[YF1dWWwdDDvcox6 M3XielI1OTF4N{C3
A549  NWfk[phlSXCxcITvd4l{KEG|c3H5 M17Gb|IvPc7:TR?= MVWyOIg> NUfqc|Rr\GWlcnXhd4V{KG:{aXTvcolvNWmwZIXj[YQh[XW2b4DoZYd6KGG|IIflcIwh[W6mIFzvd5Mhd2ZizqVPjI0h[Wy|bzDvZ4N2enKnZDDkeZJqdmdiYYX0c5Bp[WerYzDwdo9k\XO| M321T|I1OTB{NUKy
UM-SCC-10A  MWnBdI9xfG:|aYOgRZN{[Xl? MUW1NOK2VQ>? M1nvdlJp MlrYdoVlfWOnczDhdI9xfG:|aYOgbY5lfWOnZDDifUBpcWeqLXTvd4UhcXOxYXzhcpRwdGGldH;u[S=> MViyOFA6QDd3Mx?=
BGC-823 MkD3RZBweHSxc3nzJGF{e2G7 MlfQNVAh|ryP NVHNVGlXOjSq NIXSc5Zz\WS3Y3XzJJRmfHKjbnTybY5mNWmwZIXj[YQh[XCxcITvd4l{yqB? MmnGNlQxQTh3MUG=
Nalm-6  MXzBdI9xfG:|aYOgRZN{[Xl? NHnS[o4zOM7:TR?= NGfwZ|M1cA>? NV3j[4YycW6qaXLpeJMh[2G|cHHz[U05KGGwZDDjZZNx[XOnLUOgZYN1cX[jdHnvckBidmRiUFHSVE0yKGOuZXH2ZYdm NXPoVoM4OjRyM{m5Olc>
KHOS  NXPjeGtpSXCxcITvd4l{KEG|c3H5 NVS1[Y4xPDEQvF2= MlfnNlRp NWXMdIp5[myxY3vzJJRp\SCrbnPy[YF{\WRiY3zlZZZi\2Vib3[gZ4F{eGG|ZT2zJIFv\CCSQWLQJIlv\HWlZXSgZpkhSkKPRERCpC=> NVqxcItROjRyMkWzOlE>
G292 NH[2XFdCeG:ydH;zbZMhSXO|YYm= MV20NO69VQ>? MmDNNlRp MnXHZoxw[2u|IITo[UBqdmO{ZXHz[YQh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|IHHu[EBRSVKSIHnu[JVk\WRiYomgRmJOTDQEoB?= M4XVe|I1ODJ3M{[x
MG-63 MnWzRZBweHSxc3nzJGF{e2G7 NGPucXg1OM7:TR?= M{LDVVI1cA>? NHGxXXljdG:la4OgeIhmKGmwY4LlZZNm\CClbHXheoFo\SCxZjDjZZNx[XOnLUOgZY5lKFCDUmCgbY5lfWOnZDDifUBDSk2GM9Mg NGDtPI0zPDB{NUO2NS=>
EBV-transformed B cells NYXwOINVSXCxcITvd4l{KEG|c3H5 M1;hdVIx|ryP MYOybC=> M{\qTGROW09? NEHwdYZjdG:la4OgZY51cS2FREiwJIFv\CCjboTpMWNFQDZiYX70bYJw\HlvaX7keYNm\CCjcH;weI9{cXN? M{nY[VI1ODB6NkK4
IM-9 B NETVNGVCeG:ydH;zbZMhSXO|YYm= MVuyNO69VQ>? MVWybC=> M{\5OWROW09? Mn[4Zoxw[2u|IHHueIkuS0R6MDDhcoQh[W62aT3DSFg3KGGwdHnic4R6NWmwZIXj[YQh[XCxcITvd4l{ M4PSWVI1ODB6NkK4
CNE1 M2jKPWFxd3C2b4Ppd{BCe3OjeR?= NXzGOJBVOjEQvF2= NUfxV2t3PDiq MWTicI9kc3NiTFutRU1qdmS3Y3XkJIFxd3C2b4Ppdy=> M4PSNlI{QTh3MEK5
CNE2 M4\iWmFxd3C2b4Ppd{BCe3OjeR?= NWLMZYZkOjEQvF2= MnHmOFhp MX3icI9kc3NiTFutRU1qdmS3Y3XkJIFxd3C2b4Ppdy=> MnvzNlM6QDVyMkm=
HL-60 MYTBdI9xfG:|aYOgRZN{[Xl? NVnHVWdNPTEEtV2= M{XMbFFp M1XaNWROW09? NXLyN2ZNcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliQlGxOFU> NFTRS3kzOzl2OEe1NS=>
L929 M1PHeWFxd3C2b4Ppd{BCe3OjeR?= M3LvXFEvOjYkgKO1xsDPxE4EoB?= NWK2fZU5OjSq NIi5OI9ifWevZX70d{BVVkcQsT3pcoR2[2WmIH7lZ5JweHSxc3nzJIFv\CCjdYTvdIhi\3l? Mk\WNlM6PDF5Nkm=
Jurkat MnjRR4VtdCCYaXHibYxqfHliQYPzZZk> NF:0N2cz|ryP MnnIOIg> MXHy[ZZmenOnczDndo94fGhiaX7obYJqfGmxbjDhcoQh|rJvY3H0[Y5qdiCmZXPy[YF{\SCkeTDIV{1CW0F? NVi1WWFiOjN6OU[wOlE>
RAW264.7  NUHINIhpSXCxcITvd4l{KEG|c3H5 MV6xNEDPxE1? M2P5ZlI1cA>? MkG2[IVkemWjc3XzJJRp\SCjcH;weI9{cXNiaX7keYNm\CCkeTDHRS=> NITrUoszOzh{MEKwNy=>
A431  Ml7tT4lv[XOnIFHzd4F6 NVXNZm51PDEQvF2= MkjWNog> MVnicI9kc3NiZnnz[ZRqdi2rbnT1Z4VlKGOuZXH2ZYdmKG:oIHPhd5Bie2W|IHHu[EBRSVKS MVSyN|gxODB3OB?=
Jurkat NHPDOZdE\WyuIG\pZYJqdGm2eTDBd5NigQ>? Ml\hNlUuOTByzszN NXvjRnhRPmh? NHfsS4tqdmirYnn0d{B7NU[DLVPNT{1qdmS3Y3XkJINmdGxiZHXheIg> NWLMd4lwOjN7M{O1N|I>
COS-7  NV3KV2Z3TnWwY4Tpc44hSXO|YYm= NV64T5NPPTEEtV2= NFux[YQzPGh? NU\sN4Vq[W[oZXP0d{B1cGVicILvZ4V{e2mwZzDv[kBCXE5zczD3bZRpKHCxbInRJJRz[WO2cx?= NFT0TGczOzl|M{KwPC=>
CAL27 MnTBRZBweHSxc3nzJGF{e2G7 MkXsNVAh|ryP MUiybC=> M2i1bJN2eHC{ZYPz[ZMhS3W{LV7Qd{1z\WS3Y3XkJJZq[WKrbHn0fUBjgSC3cDD0c{A6OCV? M2TTXlI{QTF5M{m2
THP-1  NFHWUWdCeG:ydH;zbZMhSXO|YYm= MVqxNE02OM7:TR?= MV[ybC=> M1:1R4lvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KHS{aYD0c4xq\GV? MWiyN|kxODJ7OR?=
K562 NYL6bVJwSXCxcITvd4l{KEG|c3H5 MofyNlDPxE1? MWO0PIg> MlWybY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkhPC2PVR?= MoHSNlM5PzZ6Mk[=
HL-60 MX;BdI9xfG:|aYOgRZN{[Xl? NV\kZW9yOTByzszN MkL6NlRp NULaWldPcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliYXLp[ZRidmViZHn0[ZJx\W6nc9Mg M3vyeVI{QDZ3N{e4
HeLa  M2e5WWFxd3C2b4Ppd{BCe3OjeR?= M4H0TFIx|ryP Mln2Nog> MVjpcohq[mm2czDEUW1RKGmwZIXj[YQh[XCxcITvd4l{ MXWyN|g3Ozl4Nh?=
U251 M2rIOWFxd3C2b4Ppd{BCe3OjeR?= NFLOT|IzOM7:TR?= NUfWUG41OjSq MkHMbY5pcWKrdIOgZ4F{fGmlaX6gbY5lfWOnZDDHNk9OKHCqYYPlJIFzemW|dDDhcoQh[XCxcITvd4l{ M{\odVI{QDF4OEG2
HL-60 MXnBdI9xfG:|aYOgRZN{[Xl? NXTl[lZZPTEEtV2= M{f3fFRp MXricI9kc3NidHjlJINt\WG4YXflJI9nKGOjc4Dhd4UuOyxiLUmsJIFv\CCSQWLQJIlv\HWlZXSgZpkhPnN? NVf1OmNROjN6MES3NFY>
Ec-109 NGfMcGxCeG:ydH;zbZMhSXO|YYm= MXSxNEDPxE1? MVm0PIg> NVfY[WdxemWycnXzd4V{KFCHLX3l[IlifGWmIFXjMVExQSClZXzsJIFxd3C2b4Ppdy=> M4T3bFI{Pzh{NkSx
RKO M2TrSWNmdGxiVnnhZoltcXS7IFHzd4F6 MYixNEDPxE1? MoHQNlRp MXnpcohq[mm2czD0bIUh\GWlcnXhd4Uhd2ZiY3XscEB3cWGkaXzpeJkh[2G3c3XkJIJ6KESDQh?= NHvO[I0zOzd3OEC2OC=>
T98G NF3WToJE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M3PaTVEuOTByzszN NInReJUzPGh? MUjpcZBzd3[nczDj[YxtKH[rYXLpcIl1gSClb4Ty[YF1dWWwdDD3bZRpKFSV NWnoW5FHOjN5NkmyO|U>
Jurkat NXrXSZZzS2WubDDWbYFjcWyrdImgRZN{[Xl? MnjvNVAxNTJyMN88US=> NXvVXI1WOjSq NELxXnNqdmirYnn0d{BJ[UF2IHnu[JVk\XNiYYDvdJRwe2m|IHTldIVv\GWwdDDv[kBkd26lZX70doF1cW:wwrC= MmfaNlM4OzJ2OEG=
Molt-3  M4jmeGFxd3C2b4Ppd{BCe3OjeR?= NW\pcZlIPTEQvF2= MkXyNog> MUny[YR2[2W|IH3lcIF1d26rbj3pcoR2[2WmIHHwc5B1d3Orcx?= Ml3ONlM4OjVyMUO=
hMSC12 NHTKT5pCeG:ydH;zbZMhSXO|YYm= MUCxNFDPxE1? Ml7VOIQ> NUfYZYhzcW6qaXLpeJMhd3O2ZX;n[Y5q[yCldXz0eZJmNWmwZIXj[YQh[2WubDDk[YF1cCCjbnSgZ4Ft[2moaXPheIlwdg>? MoP6NlM3PTd6MkK=
HM7  MVrBdI9xfG:|aYOgRZN{[Xl? MYKyNO69VcLi NHywfHQycA>? MlHRZoxw[2u|IHHwbYN2dGG{ZX6gRUBi[2W2YYTlMYlv\HWlZXSgZ4F{eGG|ZT2zJIFkfGm4YYTpc44h[W6mIGDBVnAh[2ynYY\h[4U> Mn;lNlM2QDN2MUK=
Hep-2  NH7RcnJCeG:ydH;zbZMhSXO|YYm= MXeyNO69VcLi MmS3NlRp Mmm3SG1UVw>? NFfZfldidGyndnnheIV{KHSqZTDk[YNz\WG|ZTDv[kBk\WyuII\pZYJqdGm2eTDpcoR2[2WmIHL5JJNqdGmkaX7pci=> NIHiT2ozOzV6MECzNi=>
HSCs MoDWRZBweHSxc3nzJGF{e2G7 NIf0Z2I2OM7:TR?= M4TMe|I1cA>? NVXXN5VSTE2VTx?= M4XXNIlvcGmkaYTzJI5qdG:2aX7pZk1qdmS3Y3XkJGRPSSCmYX3h[4UhcW6maXPheIVlKGK7IGDBVnAh[2ynYY\h[4U> NUjESnFXOjN2OUm4O|Q>
HL-60  MoDnR5l1d3SxeHnjbZR6KEG|c3H5 M2XyRlIx|ryPwrC= Mm[2NlRp M3TGUpJm\HWlZYOgeIhmKGO7dH;0c5hq[yCnZn\lZ5Qhd2ZiRYL5OS=> M{L0OVI{PDl2NEiw
HA NVTPb29kSXCxcITvd4l{KEG|c3H5 MUe1NO69VQ>? MkHjNlRp MXnzeZBxemW|c3XzJJRp\SClbHXheoFo\SCxZjDQRXJRKGGwZDDjZZNx[XOnLUOsJE04NCCjbnSgMVkhcW6mdXPl[EBjgSCkb4L0[ZpwdWmkL2PBTGE> NYT0TnlXOjN2N{W5OVY>
C666-1 MWfBdI9xfG:|aYOgRZN{[Xl? MYC1NO69VQ>? M4P6fVI1cA>? M3n2UJN2eHC{ZYPz[ZMhfGinIHPs[YF3[WenIH;mJHBCWlBiYX7kJINie3Cjc3WtN{whNTduIHHu[EAuQSCrbnT1Z4VlKGK7IHLvdpRmgm:vaXKvV2FJSQ>? NVThPItLOjN2N{W5OVY>
Hepa1-6 NETw[mtCeG:ydH;zbZMhSXO|YYm= NIPkWGI2OM7:TR?= NFjSPJozcA>? MorFbY5pcWKrdIOgZ5Vz[3WvaX6gZY5lKHKnc4\ldoF1em:uLXnu[JVk\WRiYYDvdJRwe2m| MXOyN|Q1Pjd3Mx?=
PLC/PRF/5c NFfyWVZCeG:ydH;zbZMhSXO|YYm= M3nre|Ux|ryP NIL3[JEycA>? M3vW[5Bz\X[nboTzJIFxd3C2b4Ppd{B1emmpZ3Xy[YQh[nliQ1nO NGHQR5czOzR|OEiyOC=>
HCT116 M1WwWGFxd3C2b4Ppd{BCe3OjeR?= Ml7pNVAx|ryP NF\wWmgyNjWq NF;4SYtqdmirYnn0d{BQey2rbnT1Z4VlKGOnbHyg[IVifGh? M1\vd|I{PzR2M{Wz
HCEC MYXGeY5kfGmxbjDBd5NigQ>? M1u3R|Ux|ryP NVXafmdSPzKq NXjpWo9kTE2VTx?= M1ewb5Jme3SxcnXzJI9nKHSqZTDuc5Ju[WxiSFPFR{BxcGWwb4T5dIU> NX7EZo92OjN5NEKwNVE>
Primary rat cerebral cortical neurons MVrBdI9xfG:|aYOgRZN{[Xl? NEG2O4wyODEQvF2= MkLkNYg> MV\wdoV3\W62czDD[E1qdmS3Y3XkJIFxd3C2b4Ppd{BidmRiY3XscEBl\WG2aB?= NFX2RW8zOzd2MUOxOy=>
MDA-MB-231  NEnINohCeG:ydH;zbZMhSXO|YYm= MlnXNlXPxE1? MXKyOIg> NWfzdYJT[WK{b3fheIV{KGO7dH;0c5hq[2m2eTDhcoQh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|IHHu[EBRSVKSIHnu[JVk\WRiYomgVoc{ NUXTRYY2OjV|M{e1OFQ>
NLRP3-Tet-on-MC/9  MmCwRZBweHSxc3nzJGF{e2G7 MljGNVAuPDEQvF2= NH3xTZYyOmh? MVnheJRmdnWjdHXzJJRp\SClZXzsJIRm[XSqIHPheZNm\CCkeTDDRXBUNWG|c3;jbYF1\WRiTlzSVFMhdXW2YX70d{BqdiC2aHWgWIV1NW:wIIP5d5RmdQ>? NH75UIEzOzdyM{O4PS=>
KNS42  M4D4XWFxd3C2b4Ppd{BCe3OjeR?= MnToOVDPxE1? M4Hie|Fp M1PzUZJm\HWlZYOgZ4VtdCCmZXH0bEBidmRiY3;tdIxmfGWueTDhZo9tcXOqZXSgZ4F{eGG|ZTCzM|ch[WO2aY\peJkhcW5icnXzdI9ve2VidH:gRWJVNTJ4Mz:ySGcwdWW2Zn;ycYlvKGOxbXLpcoF1cW:w MnH0NlM3QTFzNEW=
MCF-7  MVHBdI9xfG:|aYOgRZN{[Xl? MoTnNlDPxE4EoB?= NEnOWmM4Omh? M2\icolvcGmkaYTzJIVyfW:uLTDhcoQhPC2RSGStcYVlcWG2ZXSgZZBweHSxc3nz MUGyN|Y4PTZ2Mx?=
hCMEC/D3  NYS5TYc{SXCxcITvd4l{KEG|c3H5 NUPQR3FxOjYQvF2= MnPGO|Jp NXv6S2gyemWmdXPld{BNfHiDIHnu[JVk\WRiYYDvdJRwe2m| M4\1UlI{PjZ3MUm4
Jurkat MXzBdI9xfG:|aYOgRZN{[Xl? MV:xNk42NTVyzszN Mn;TNYg> NGnXZZlld3OnIHTldIVv\GWwdHz5JJN2eHC{ZYPz[ZMhW1CKLXnu[JVk\WRiUHHyMVQh[2ynYY\h[4UtKFCDUmCgZ4xm[X[jZ3WsJGRPSSCocnHncYVvfGG2aX;uMEBidmRibH;zd{Bw\iC4aXHibYxqfHl? MUWyN|Q1Ojl5Nh?=
CNE-1 NVHEW|F6SXCxcITvd4l{KEG|c3H5 NXr5WWdwOjEQvF5CpC=> MUGyOIg> MV3pcohq[mm2czDSRWQxODFvaX7keYNm\CClZXzsJIRm[XSq MVuyN|QzPjh3MB?=
HONE-1 MYDBdI9xfG:|aYOgRZN{[Xl? NWnkfnJSOjEQvF5CpC=> MVKyOIg> MmXwbY5pcWKrdIOgVmFFODBzLXnu[JVk\WRiY3XscEBl\WG2aB?= NYrp[IpXOjN2Mk[4OVA>
astrocytes cell NGXDVopCeG:ydH;zbZMhSXO|YYm= MmDZOFDPxE1? Ml7WOog> NX3FdZFFemWmdXPld{Bm[XKueTDhdI9xfG:|aYOgbY5lfWOnZDDifUB{fGG3cn;zdI9zcW6n Moq5NlM1OTF5N{i=
U-937 NYj0bGhRSXCxcITvd4l{KEG|c3H5 MXOxNO69VQ>? NF;VXZE{OG2rbh?= NIDZW29xemW4ZX70d{BVVkZvaX7keYNm\CCwZXPyc5B1d3Orcx?= MVyyN|QyODd2OB?=
MDA-MB-231 NIWxU3pCeG:ydH;zbZMhSXO|YYm= NVvtO3dSOTByzszN MWCxbC=> M4f6TolvcGmkaYTzJJNmdnOrdHn6ZZRqd25idH:gWHJCUUxidYDvckBOXESKIHTve44uemWpdXzheIlwdg>? NGfoT48zOzRyOESyPS=>
HeLa  MlHhRZBweHSxc3nzJGF{e2G7 Ml;uNVAx|ryP MkD4Nog> NX3OTZZ5[myxY3vzJGpTWy1zNTDJcoR2[2W|IFHwc5B1d3SrYzDD[YxtKESnYYTo M2r0flI{OzR2MES1
Ec109 MWHBdI9xfG:|aYOgRZN{[Xl? M4PwXFEx|ryP MlvsOog> NEjVSZJjdG:la4OgZZBweHSxdHnjJINwdWKrbnH0bY9vKG:oIGTheE1UdWGlTkegZY5lKHKjZHnheIlwdg>? MnLmNlM{Ozh3Nki=
H460  M4L3d2Fxd3C2b4Ppd{BCe3OjeR?= M2XQSlEx|ryP MmW2Oog> MnjTZoxw[2u|IHHwc5B1d3SrYzDjc41jcW6jdHnvckBw\iCWYYStV41i[055IHHu[EBz[WSrYYTpc44> NVvZXodSOjN|M{i1Olg>
HeLa  M2fGPWFxd3C2b4Ppd{BCe3OjeR?= M1\vZVUx|ryP NY\aSId5OS53aB?= NXntWnNE[WK{b3fheIV{yqCFaHzhcZllcWFvaX7keYNm\CCjcH;weI9{cXN? MmXWNlM{ODN6MES=
SK-HEP1 MWDBdI9xfG:|aYOgRZN{[Xl? MkTnNVAx|ryP M1;xTlFp NGDnc5VqdmirYnn0d{BEelRzIHHjeIl3[XSnZDDjZZNx[XOnLUOsJE04NCBvODygMVktKGGwZDDwc4x6MEGGUD3ybYJwe2VrIIDvcJlu\XKjc3W= M2XMTVI{OzB{NkWw
QGY7701 NED3fY9CeG:ydH;zbZMhSXO|YYm= NXHEO4pYOjYQvF2= M3LkN|EvPWh? MXPpcohq[mm2czDhZ4N2dXWuYYTpc44hd2Zic4XiMWcyKHCqYYPlJIlv\HWlZXSgZpkhTE:[IDugdZVmemOndHnu NUHiXI0xOjN{NECwOlE>
HepG2 Ml3PRZBweHSxc3nzJGF{e2G7 NHi4WJgzOM7:TR?= NIjzT|Y{OG2rbh?= NF\ofZRqdmirYnn0d{B1cGViZX7oZY5k\WRiY3XscEBl\WG2aDDifUBkd22kaX7l[EB1emWjdH3lcpQhd2ZiYYDp[4VvcW5iYX7kJHRTSUmO MWGyN|IzPDJ|OR?=
U87  MWLBdI9xfG:|aYOgRZN{[Xl? NUe4bFgzOjYQvF2= NIfIZ3IzcA>? MU\k[YNz\WG|ZYOgbZNwdGmzdXnybZRq\2WwaX6gLGlUVClvaX7keYNm\CCjcH;weI91cWNiY3XscEBl\WG2aDygZpV1KG6xdDDu[YNzd3SrYzDj[YxtKGSnYYTo NGewboMzOzJ{OU[yOi=>
HSC-2 MVzBdI9xfG:|aYOgRZN{[Xl? NYjv[|M1OjVxNUFOwG0> M3TaSFFp NFfOZpNqdmirYnn0d{BUVi1|OD3pcoR2[2WmIHP5eI91d3irY3n0fS=> NF;tc4YzOzF3NUK0PC=>
HSC-4 MlexRZBweHSxc3nzJGF{e2G7 MlKwNlUwPTEQvF2= MX2xbC=> MXHpcohq[mm2czDTUk0{QC2rbnT1Z4VlKGO7dH;0c5hq[2m2eR?= MW[yN|E2PTJ2OB?=
CL-1 M4TDOGFxd3C2b4Ppd{BCe3OjeR?= M2PZbVIx|ryP M1XVXlFp M1KzTYJtd2OtczDPVFQ1QSCrbnT1Z4VlKGOnbHyg[IVifGh? MlnoNlMyOzF5OEK=
MEL MnfzRZBweHSxc3nzJGF{e2G7 MnfaNlDPxE1? MYSyOIg> NX;F[45{TE2VTx?= NFfD[mNqdXCjaYLld{BROlh5LXnu[JVk\WRiTVXMJINmdGxiYYDvdJRwe2m| NIW3[lgzOzBzNEi4Oy=>
Bel-7402  MY\DZZNx[XOnIFHjeIl3[XSrb36gRZN{[Xl? Mlf3OVDPxE1? M3TQUFJp NYnqU2JycW6qaXLpeJMhWEOHLXnu[JVk\WRiYX7vbYtqew>? NVjnWZNuOjNyMEi3OFI>
Eca-109 M3vNUWFxd3C2b4Ppd{BCe3OjeR?= MVmyOe69VQ>? NUHqcIJzOzCvaX6= NFLqdJlqdmirYnn0d{BDUi2EMUGtbY5lfWOnZDDj[YxtKGSnYYTo M4\TcVI{ODd4OU[3
MEL MmjNRZBweHSxc3nzJGF{e2G7 MknPNlDPxE1? MWSxbC=> NFS4NnZFVVOR MofvbY1x[Wm{ZYOgVFJZPy2rbnT1Z4VlKE2HTDDj[YxtKGGyb4D0c5Nqew>? Mkj0NlMxOTR6OEe=
Bel-7402  NHLFc2FCeG:ydH;zbZMhSXO|YYm= NGPMN482OM7:TR?= MYGybC=> NWH5XVQzcW6qaXLpeJMhWEOHLXnu[JVk\WRiYX7vbYtqew>? M2\aclI{ODB6N{Sy
L929 NW\3[VJXTnWwY4Tpc44hSXO|YYm= MmrMNk42|ryP M3rscVFp M2HwSIlv[3KnYYPld{BTUVBzIHX4dJJme3Orb36gZY5lKGW6YXPldoJifGWmIGTOSu6yNWmwZIXj[YQhdWm2b3Poc45lemmjbDDkfZNnfW6ldHnvckBidmRiUl;TJJBzd2S3Y4Tpc44> NILIcHgzOzByMEWxPC=>
RCC  MYfD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NGLjepQyODEQvF2= NXXyW3hXOjSq MWHy[YNwfmW{ZYOgeIhmKH[rYXLpcIl1gSCxZjDj[YxteyCneIDvd4VlKHSxIEG1[E1RT0p{ M13tNFIzQTlzNEm0
NB2a/d1 MX\BdI9xfG:|aYOgRZN{[Xl? MXuxNFDPxE1? NIruWYo4Omh? NHnTclNifHSnboXheIV{KHO2YYXyc5Nxd3KrbnWtbY5lfWOnZDDjZZNx[XOnIHHjeIl3cXS7LDDQRXJRNCCjbnSgeIF2KGOuZXH2ZYdm M3PvPVIzQTh6NUSx
T cell MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUmyOU0yODEQvF2= MYOyOIg> NH;mTYdld3OnLXTldIVv\GWwdHz5JIlvcGmkaYTl[EBVKGOnbHygdJJwdGmoZYLheIlwdiCvZXTpZZRm\CC2aILveYdpKHSqZTDjc{1{fGmvdXzheIlwdiC5aYToJIFvfGlvQ1SzJIFv\CCjboTpMWNFOjh? M3fZU|IzQTh{NUO4
K562 NX3TSmhnSXCxcITvd4l{KEG|c3H5 MnP5NVAx|ryP MUexbC=> NYfweIZY[myxY3vzJGFjdm:kYY\pd4N2dcLiRj3pcoR2[2WmIHHwc5B1d3Orcx?= NFyyeWkzOjl5MkO3Ni=>
Jurkat  M{DpSmFxd3C2b4Ppd{BCe3OjeR?= M4r5cVQx|ryP NXfXNpVROWh? MU\hZo9tcXOqZYOgSoF{VC2rbnT1Z4VlKGOjc4Dhd4Uh[WO2aY\heIlwdiCjbnSgZ4VtdCCmZXH0bC=> NXTJW2JROjJ7NEK3N|g>
BGC-823 MUjBdI9xfG:|aYOgRZN{[Xl? MVixNFDPxE1? M17L[FFp NV7VbJNSeGG{dHnhcIx6KHKnc3P1[ZMh[2WubIOgZYdicW6|dDDkZY1i\2Vib3[g[IFq\HqnaX6= MV[yNlkzPjV2NR?=
Hep3B MnfMRZBweHSxc3nzJGF{e2G7 MXu1NO69VQ>? NV\CWWRtOWh? NFm1ZWhjdG:la4OgZZBweHSxc3nzJIlv\HWlZXSgZpkhUEWJQ4O= NUTxUII4OjJ7MkOxOVQ>
LLC-PK1 MknqRZBweHSxc3nzJGF{e2G7 NWr0Vo9UOjEQvF2= M{LaNlFp NIj5OYhxemW4ZX70d{BkcXOybHH0bY4ucW6mdXPl[EBl\We{YXTheIlwdiCxZjDBeIc2NCCkZXPsbY4uOSxiYX7kJGF1\zF{IIDyc5RmcW6| Mn33NlI5QTZyM{e=
A549 NH7VV2dCeG:ydH;zbZMhSXO|YYm= NGrxW5M2OM7:TR?= M2ewWlFp NF7mdXFjdG:la4OgeIhmKEKDST3pcoR2[2WmIHHwc5B1d3Orc9Mg NXnC[mg4OjJ6OEeyNVU>
SGC-7901  NVGwcncxSXCxcITvd4l{KEG|c3H5 NEfMWGIyOM7:TR?= MX6yOIg> Ml3VbY5pcWKrdIOg{tIt|rJvZHnt[ZRpgWyjY4L5cJNpcWuxbnnuMYlv\HWlZXSgZZBweHSxc3nzxsA> NInoXWczOjh2OEW5Oy=>
DM6 MmDWRZBweHSxc3nzJGF{e2G7 NG\M[3AyODEQvF2= MWK3Nog> MoDqZoxw[2u|IHLveIghTTKILUGgZY5lKEV{RoTyMY1m\GmjdHXkJIN6fG:2b4jpZ4l1gQ>? MWmyNlgzPTN{OB?=
MCF-7, MDA-MB-468, Caco-2 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonuOVDPxE1? MX20PIg> MnWybY5pcWKrdIOgeIhmKGOnbHyg[5Jwf3SqIHnubIljcXSrb36gbY5lfWOnZDDifUB{[XCxbnnu M3vrS|IzQDByOU[4
A2750  NED3UFNCeG:ydH;zbZMhSXO|YYm= NEXmWmYzOM7:TR?= M2LTfFJp MYDEUXNQ M1HEboJtd2OtczDjZZNx[XOnIHPs[YF3[WenIHT1dolv\yCqZXzlcoFtcW5idILlZZRu\W62IHHu[EBz\WS3Y3XzJIF2fG:yaHHnbYMh[2WubDDk[YF1cA>? NXHYSWNlOjJ5OESzOlM>
U87  NF63R|hCeG:ydH;zbZMhSXO|YYm= MXGyNO69VQ>? M1;NZ|I1cA>? M3\rW5Jm\HWlZYOgeIhmKGGyb4D0c5NqeyC{YYTlJIlv\HWlZXSgZpkhWEyDQh?= NYr2eZEyOjJ5N{i3PFA>
HT1080 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLFOVDPxE1? M2rXUldl MlT2bY5pcWKrdIOgeIhmKGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZ4F2e2WmIHL5JINwdWKrbnXkJJRz\WG2bXXueEBw\iCGQ1GgZY5lKE:PUB?= NHGzb5czOjd2MEm4OC=>
A549  MV\BdI9xfG:|aYOgRZN{[Xl? M3vmO|Ux|ryP M1v0eVJp NHLmdIRx[XK2aXHscJkh\GWlcnXhd4V{KHOxZHn1cUB{\Wynbnn0[U1qdmS3Y3XkJIFxd3C2b4Ppdy=> M1nmN|IzPzJzOEC0
Primary OPC Mn;WRZBweHSxc3nzJGF{e2G7 M{f0elHPxE1? M3nlT|ZpNzJ2aB?= MUTy[YR2[2W|IITo[UBx\XKlZX70ZYdmKG:oIHPlcIx{KGmwIHXhdox6NSCjbnSgcIF1\S2jcH;weI9{cXNxbnXjdo9{cXN? NYG5[5EzOjJ5MEezPFU>
PMNs Mn3YRZBweHSxc3nzJGF{e2G7 MVG0NO69VQ>? NX;2N2o4Pmh? M2rCRWROW09? M4PyT5JmfmW{c3XkJJRp\SCjbX;1cpQhd2ZiY3zlZZZm\CClYYPwZZNmNTNidH:gcoVieiC4ZXjpZ4xmKGyndnXsdy=> NH7hUmQzOjZ7MkW3Oy=>
A549  MkHLRZBweHSxc3nzJGF{e2G7 MnjzOVDPxE1? MWexbC=> NXfVNVVqeHKndnXueJMh[XCxcITvd4l{KGmwZIXj[YQh[nliQnHvbJVwe2mmZTDJ MnjPNlI3QDd4M{W=
AGS MmHjRZBweHSxc3nzJGF{e2G7 MXOyNO69VQ>? M{fhSVEzcA>? NEOxPG5qdmirYnn0d{B1cGViYXP0bZZifGmxbjDv[kBxem9vY3HzdIF{\S1|IHnuJJJme3CxboPlJJRwKHSqZTDFeG9C[yCocnHjeIlwdg>? MnnWNlI3QDd|OUi=
shC9  MX;BdI9xfG:|aYOgRZN{[Xl? M4m0XlEx|ryP Mom3NVZp NES4SXpjdHWwdIOgV2hJKGW6cILld5Nqd25iaX6gd4hEQSClZXzsd{BmgHCxc3XkJJRwKGWrdHjldkBRSSCxcjDMVGM> NWLtN4d3OjJ4NEGwPVQ>
primary MEFs MoPjSpVv[3Srb36gRZN{[Xl? M3\US|EzcA>? MnLmxsBqdmO{ZXHz[ZMh\XSxcH;zbYRmNWmwZIXj[YQhdWm2b3Poc45lemmjbDDt[Y1jemGwZTDk[ZBwdGG{aYrheIlwdg>? NEO0eWEzOjZzM{e2Oy=>
3T9 MEFs MWHGeY5kfGmxbjDBd5NigQ>? M3\rNFE3cA>? M2fQOYlv[3KnYYPld{BkgXSxY3jyc41mKGNicnXs[YF{\SCjZoTldkBmfG:yb4Pp[IUufHKnYYTt[Y51 MYiyNlYyOzd4Nx?=
3T9 MEFs NFX3Vm9HfW6ldHnvckBCe3OjeR?= NE[0e|AyQGh? Ml\PeZBz\We3bHH0[ZMhcW6rdHnheI9zKGOjc4Dhd4UuQSCkdYSg[I94dnKnZ4XsZZRmeyCnZn\lZ5RweiClYYPwZZNmeyCjZoTldkBmfG:yb4Pp[IUhfHKnYYTt[Y51 NHLNU|AzOjZzM{e2Oy=>
MDA-MB-231  MoGwRZBweHSxc3nzJGF{e2G7 MnrxNlDPxE1? NEXDc2U1\A>? MY\y[YR2[2W|IITo[UBk\WyuIHHwc5B1d3OrczDpcoR2[2WmIHL5JI1mfG[xcn3pckB1emWjdH3lcpQhf2G|IIPp[45q\mmlYX70cJk> Mo\jNlI2QTN2NEG=
C6  M2DQN2Fxd3C2b4Ppd{BCe3OjeR?= M{XPflEx|ryP MXuyOIg> NWrHN4d[[myxY3vzJJRp\SC|dYDwdoV{e2m4ZTDl[oZm[3Rib3[geIhmKHCncITp[IUhd25idnnhZoltcXS7 NULFcXRNOjJ3OEi5PFA>
HL-60  MkDyRZBweHSxc3nzJGF{e2G7 M2Hs[VExOM7:TR?= NUi0[nRiOjSq MoDTbY5pcWKrdIOgeIhmKGOnbHygZZBweHSxc3nzJJNmdGWldHXkJEgsMS2vZX70bJltKM7{LTix5qaTPilvZHnncJVkd3C7cnHuc5Nq\GYEoEW= NFLKXZczOjV2Nk[2PS=>
HL-60 MX7BdI9xfG:|aYOgRZN{[Xl? MXmxNE05OM7:TR?= Mn24OIg> MmrsbY5pcWKrdIOgWGdJWS2rbnT1Z4VlKGOnbHygZZBweHSxc3nzxsA> M4ThfFIzPTJ|MkK5
BCC MUHBdI9xfG:|aYOgRZN{[Xl? NH\Fb2I2OM7:TR?= MV2xbC=> M4Syb4lvcGmkaYTzJGRCXFNvbXXkbYF1\WRiZ4Lve5RpKGmwaHnibZRqd25? M{H3dlIzPTF7NEO2
RAW 264.7 NUHyelJ3SXCxcITvd4l{KEG|c3H5 NFPCcYw2OC9zMEFOwG0> NXfifnNbOWh? MUPjc45k\W62cnH0bY9vNWSncHXu[IVvfCCrbnjpZol1eyCGT16tbY5lfWOnZDDyVm5CKGOuZXH2ZYdm M1nJcVIzPDlzNEK2
K562 NFTOSWtCeG:ydH;zbZMhSXO|YYm= M1rJRVI2|ryP NX3yNWtqOmh? M13lNJBz\X[nboTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KGOxLYTy[YF1dWWwdDD3bZRpKGGvdYLlcpNqdiCJIHHu[EBVWkGLTB?= NXPmSpVTOjJ2OEO3O|c>
SGC-7901 MkTFRZBweHSxc3nzJGF{e2G7 MUCyNEDPxE4EoB?= M37Rc|Jp NXLxOVA{[XS2ZX71ZZRmeyCKMl:yxsBweiCWTl[g{tEucW6mdXPl[EBk\WyuIHHwc5B1d3OrczDhd{B4\WyuIHHzJINie3Cjc3WtN{Bi[3Srdnn0feKh MU[yNlQ4OTV6OR?=
PC3 MXnBdI9xfG:|aYOgRZN{[Xl? NYnPO4x7OTEQvF2= MmrZOIg> MWfjc5VvfGW{czDmcIF3d2OxeHnkMYlv\HWlZXSgZ4F{eGG|ZT3y[YxifGWmIHHwc5B1d3Orcx?= NF;aUYEzOjR5MUm3OC=>
SMMC-7721 M{T2OmFxd3C2b4Ppd{BCe3OjeR?= MV[1NO69VQ>? MXu0PIg> MmjUZZR1\W63YYTld{BwXFJvaX7keYNm\CCjcH;weI9{cXN? NFjvdmczOjR4NUizNy=>
HeLa  NGTFT2hCeG:ydH;zbZMhSXO|YYm= MnWyOVDDqM7:TR?= NXq1[Ih[PC96aB?= M2WyOIlvcGmkaYTzJHNVWy2rbnT1Z4VlKGyjdHWtdIhie2ViYYDvdJRwfGmlIHX2[Y51ew>? NEHLTnczOjR4MEWwOC=>
HeLa  NGrNfpRCeG:ydH;zbZMhSXO|YYm= MkPWOVDDqM7:TR?= M2HBVlFp Mk\1d5VxeHKnc4Pld{B1cGViRmLBVE1qdmS3Y3XkJIFk[3WvdXzheIlwdiCxZjDhco5mgGmwIG[gdI9{cXSrdnWgZ4VtdHN? M1vPSlIzPDR7NESw
T47D  M2HnN2Fxd3C2b4Ppd{BCe3OjeR?= MlzLNVAx|ryP MlnJNYg> M{DGcIJtd2OtczD0bIUh\2WwZYLheIlwdiCxZjDFMYNi\C:FVF[yJIJ6KFOWUx?= NHPHfJEzOjRyMUG2PC=>
HeLa  MWTBdI9xfG:|aYOgRZN{[Xl? M3[4VFMx|ryP MX60bC=> NECyOobDqGmwY4LlZZNmeyC2aHWg[4Vv\XKjbDDj[YxtKH[rYXLpcIl1gSB2ODDoJIFnfGW{IIDoc5Rw\HmwYX3pZ{B1emWjdH3lcpTDqA>? M1nWb|IzOzl2MkS4
HCC NUDHcIoxSXCxcITvd4l{KEG|c3H5 MlfPNlAh|ryPwrC= M1PqR|Jp MWXheJRmdnWjdHXzJJRp\SCGSFGgbY5lfWOnZDDhZ5RqfmG2aX;uJI9nKFCDUmC= NWjw[I5{OjJ|NEK3N|I>
mESCs M4HkNWFxd3C2b4Ppd{BCe3OjeR?= MojMNk42|ryP MV6ybC=> Mn;pbY5pcWKrdIOgeIhmKE6jRj3t[YRq[XSnZDDjZZNx[XOnIHHjeIl3[XSrb36= Ml;CNlIzQDV{N{S=
EMT-6  MY\DfZRwfG:6aXPpeJkhSXO|YYm= NVqzdYw1OTByzszN NHr4RZEycA>? MUHwZZJ1cWGubImgZoxw[2unZDDj[YxtKGSnYYToJIlv\HWlZXSgZpkhe2m{YX3ld4lv\Q>? M2DBdVIzOjVzOUKx
MCF7 MUPBdI9xfG:|aYOgRZN{[Xl? Moe1OVDDqM7:TR?= Mn:yNYg> NWLFZo9RcW6qaXLpeJMhWEFiYXP0bZZifGWmIHPhd5Bie2VvMzygMVktKGGwZDDwc4x6MEGGUD3ybYJwe2VrIIDvcJlu\XKjc3W= MYKyNlIzOzN2NR?=
K562 M2PZU2Fxd3C2b4Ppd{BCe3OjeR?= M1zZ[VIxKM7:TdMg NYn0PZRmPDiq NVvESmxRTE2VTx?= M3TO[oJtd2OtczDsZZBifGmwaXKtbY5lfWOnZDDpcohq[mm2aX;uJI9nKH[rYXLpcIl1gSCjbnSgZZBweHSxc3nzJIlv\HWldHnvci=> NYTueZhlOjJ{MU[xOVg>
Molt4-hyg MkLSRZBweHSxc3nzJGF{e2G7 NFjjdGQyOM7:TR?= M1nHeVAvPWh? MWficI9kc3NiZnHycoV{d2xvaX7keYNm\CClYYPwZZNmNTNvbHnr[UBi[3Srdnn0fS=> NYTWPJhGOjZ{N{W4NVE>
HeLa MV\BdI9xfG:|aYOgRZN{[Xl? M{[zV|Ex|ryP MYCwMlVp NGm5ZmxqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSC2aHWgZ49u[mmwZXSgeJJm[XSvZX70JJdqfGhiZ3;tbZNqdiCQIHHu[EBVWkGLTB?= M13tUVIzOTd7Nk[x
Jurkat T NUf4PHo{SXCxcITvd4l{KEG|c3H5 MYizNO69VQ>? Mn3jNE42cA>? NUXhSms6TE2VTx?= MUjicI9kc3NidHjlJJpqemGvLXnu[JVk\WRiYYDvdJRwe2m| MX[yNlE2QTh7OB?=
Neutrophil M4XXcmFxd3C2b4Ppd{BCe3OjeR?= MVeyNO69VQ>? MnPHNE42cA>? MULheJRmdnWjdHXzJJRp\SCycn:tZZBweHSxdHnjJIVn\mWldDDv[kBO[VJz NG\CXVQzPjF7Nki0OC=>
HCT116 M3fNfmFxd3C2b4Ppd{BCe3OjeR?= NYi5bHZzPTEEoN88US=> M2nBdFJp MW\y[ZZmenOnczDzfY5memerc4TpZ{BieG:ydH;zbZMh\W[oZXP0d{Bw\iClZXzlZ495cWJiYX7kJG5RSy1zNtMg NF\yeoozOjF3OUe1Ni=>
MDA-MB-231  NETrfG5CeG:ydH;zbZMhSXO|YYm= NWfMeng5Oi53LUeuOe69VQ>? MWSybC=> NHz0dGtqdmirYnn0d{B1cGViY3XscEBl\WG2aDDv[kBOTEFvTVKtNlMyKGOnbHzzJIlv\HWlZXSgZpkhW0SWIHnuJIEh[2:wY3XueJJifGmxbjDk[ZBmdmSnboSgcYFvdmW{ MU[yNlEyPTV{Nh?=
LNCaP M1jwbGFxd3C2b4Ppd{BCe3OjeR?= NXGwTotwPDEQvF2= MkizNog> M3fYWolvcGmkaYTzJIJ2fGWrbjDpcoR2[2WmIHPlcIwh[XCxcITvd4l{ NEPtVZEzOjFzNEe2OC=>
MB231 MlWzRZBweHSxc3nzJGF{e2G7 NVzzXGp3OTByzszN NH;JUFkycA>? NXTZXZoyTE2VTx?= NGXwe4li[nKxZ3H0[ZMhfGinIHnu[JVkfGmxbjDv[kBk\WyuIHTlZZRpKGK7IGfFSVEhcW6qaXLpeIlwdixiVGLBTWwhfHKnYYTt[Y51NCCjbnSgeIhmKGOxbXLpcoF1cW:w MXGyNlEyOjl2MB?=
HCC38  M3fJSGFxd3C2b4Ppd{BCe3OjeR?= MV2xNFDPxE1? NX2xSHhvOWh? M{nXWGROW09? Mlm0ZYJzd2ejdHXzJJRp\SCrbnT1Z5Rqd25ib3[gZ4VtdCCmZXH0bEBjgSCZRVWxJIlvcGmkaYTpc44tKFSUQVnMJJRz\WG2bXXueEwh[W6mIITo[UBkd22kaX7heIlwdg>? NWD4WIVNOjJzMUK5OFA>
MDA-MB231 MoK0RZBweHSxc3nzJGF{e2G7 MUe1NOKh|ryP NWTiOohpOjSq NWn0V3pYTE2VTx?= NFPCR3Ri[nKxZ3H0[ZMh[3W{Y4XtbY4ucW6mdXPl[EBk\WyuIHTlZZRp MojTNlIyODF|M{W=
LNCaP M1;jUmFxd3C2b4Ppd{BCe3OjeR?= NG[xRmg2OMLizszN M4DGbVI1cA>? NXnWSXZZTE2VTx?= Mkn0ZYJzd2ejdHXzJIN2emO3bXnuMYlv\HWlZXSgZ4VtdCCmZXH0bC=> MWCyNlExOTN|NR?=
HCT116 MWTBdI9xfG:|aYOgRZN{[Xl? MX[1NOKh|ryP NWfCNWV2OjSq NHGzdFJFVVOR MYHhZpJw\2G2ZYOgZ5Vz[3WvaX6tbY5lfWOnZDDj[YxtKGSnYYTo MlLKNlIyODF|M{W=
Ishikawa  NVn5cY5DSXCxcITvd4l{KEG|c3H5 NHjjfJUzPc7:TR?= NVHXWXVmOjSq MWny[YR2[2W|IHPlcIwh\GWjdHigZY5lKGGyb4D0c5NqeyCrbnT1Z4VlKGK7IFLh[kBCOQ>? M3;yOFIzODh6OUG4
 YD-8  NFLCdXRCeG:ydH;zbZMhSXO|YYm= M{TyeVExOM7:TR?= MkPJNYg> M{H0bIlvcGmkaYTzJHBNTU9vaX7keYNm\CCjcH;weI9{cXN? MXSyNlA5PjF6Mx?=
eosinophil  MlPPRZBweHSxc3nzJGF{e2G7 NVnMT5lvQTEQvF2= MUOyOIg> M{iyVYlvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KE[jczDhcpRq[m:medMg NXG1Znd7OjJyN{mzN|Q>
L929 Moe1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV2yMlXPxE1? NEnKPZQzPGh? M{C5S4lvcGmkaYTzJJRp\SCneIDy[ZN{cW:wIH;mJJAueDN6IHHu[EBPTi4QulKgeI8h[XWpbXXueEBVVkcQsT3pcoR2[2WmIH7lZ5JweHSxc3nzJIFv\CCjdYTvdIhi\3l? MWeyNlAzPzB7Nx?=
YD-8  MV;BdI9xfG:|aYOgRZN{[Xl? NXPqZ45[OTByzszN M1r3d|Fp NH;RUVJjdG:la4OgeIhmKEeVLVjDcE1qdmS3Y3XkJIFxd3C2b4Ppdy=> MYGyNlAzODB5OB?=
HBx M4XEe2Fxd3C2b4Ppd{BCe3OjeR?= MVuyOe69VQ>? MoXVOFhp NWf4[3N{TE2VTx?= MYLy[YR2[2WmIHPlcIwh\GWjdHigbY5lfWOnZDDifUA{NU2D M1jGVlIzODJyMEe4
U937  MVvBdI9xfG:|aYOgRZN{[Xl? NED4emw2OMLizszN MlzSNYg> M3r1O4lvcGmkaYTzJGhHNWmwZIXj[YQh[XCxcITvd4l{yqB? NHnuZogzOTl7OEezNS=>
HL60 MoLZRZBweHSxc3nzJGF{e2G7 MYG0NO69VQ>? NH;2bm41OG2rbh?= NWTlTY96TE2VTx?= NYjUPG1z[myxY3vzJGJPTENiY3;tdI92dmS|IHnu[JVk\SCneIDvd5Vz\SCxZjDwbI9{eGijdHnkfYx{\XKrbnWgZY5lKESQQTDmdoFodWWwdHH0bY9v MnXHNlE6QDN{OU[=
M-14 MUjBdI9xfG:|aYOgRZN{[Xl? NYHxcZVkOjYQvF2= MWmwMlVp MYZCpIlvcGmkaYTzJIJwfGhidHjlJINzfWSnIHX4eJJi[3RvIHHu[EBkd22yb4Xu[E1qdmS3Y3XkJIFxd3C2b4Ppdy=> M{eyR|IyQTV2OUW5
SK-BR-3 NXzUU5B3SXCxcITvd4l{KEG|c3H5 M4jUSVUxyqEQvF2= M3K5d|Jp MmTXZoxw[2u|IHHwc5B1d3SrYzDEUmEh\nKjZ33lcpRifGmxbjDpcoR2[2WmIHL5JINwdWKrbnH0bY9vKG:oIGPNMVE3PCCjbnSgdoFlcWG2aX;u M2\0R|IyQTBzM{i2
MDA-MB-468 MlGxRZBweHSxc3nzJGF{e2G7 MUS1NOKh|ryP NVPmSGZsOmh? MXzicI9kc3NiYYDvdJRwfGmlIFTORUBnemGpbXXueIF1cW:wIHnu[JVk\WRiYomgZ49u[mmwYYTpc44hd2ZiU12tNVY1KGGwZDDyZYRq[XSrb36= MmHSNlE6ODF|OE[=

多くの細胞株試験データを見る場合、クリックしてください

体内試験 In vivo Z-VAD-FMK administration has been shown previously to be nontoxic and to prevent apoptosis in animal models. Intraperitoneal HK-GBS injection leads to preterm delivery, and pretreatment with Z-VAD-FMK delays preterm delivery in mice. In OVA-sensitized mice,treatment of z-VAD-fmk inhibits allergen-induced leukocyte infiltration. Systemic injection of the pan-caspase inhibitor z-VAD-fmk immediately before OVA challenge reduced inflammatory cell accumulation, mucus hypersecretion, and Th2 cytokine release in OVA-sensitized/challenged mice. Treatment with z-VAD-fmk blocked terminal differentiation of lens epithelial cells and keratinocytes, the differentiation of monocytes into macrophages, and the differentiation of erythroid progenitors. z-VAD-fmk attenuated allergen-induced airway inflammation and hyperreactivity. Treatment with z-VAD-fmk in vivo also prevented subsequent T cell activation ex vivo[7].

お薦めの試験操作(参考用のみ)

細胞試験:

[6]

+ 展開
  • 細胞株: human granulosa cell lines (GC1a, HGL5, COV434)
  • 濃度: 50 μM
  • 反応時間: 48 h
  • 実験の流れ:

    To validate the efficacy of Z-VAD-FMK, three human granulosa cell lines (GC1a, HGL5, COV434) were treated for 48 h with etoposide (50 μg/ml) and/or Z-VAD-FMK (50 μM) under normoxic conditions. To mimic the ischemic phase that occurs after ovarian fragment transplantation, cells were cultured without serum under hypoxia (1 % O2) and treated with Z-VAD-FMK. The metabolic activity of the cells was evaluated by WST-1 assay. Cell viability was determined by FACS analyses. The expression of apoptosis-related molecules was assessed by RT-qPCR and Western blot analyses.


    (参考用のみ)
動物試験:

[7]

+ 展開
  • 動物モデル: CD1 mice
  • 製剤: dissolved in DMSO, diluted in PBS (final concentration of DMSO < 1%)
  • 投薬量: 10 mg/kg
  • 投与方法: i.p.
    (参考用のみ)

溶解度 (25°C)

化学情報

分子量 467.49
化学式

C22H30FN3O7

CAS No. 187389-52-2
保管
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    What is difference between S7023 & S8102?

  • 回答:

    Unlike S7023, S8102 does not require pretreatment with esterase for in vitro studies. This information was cited from the article: https://www.ncbi.nlm.nih.gov/pubmed/16973565.

Related Antibodies

Caspaseシグナル伝達経路

相関Caspase製品

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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID