Z-VAD-FMK

製品コードS7023

Z-VAD-FMK化学構造

分子量(MW):467.49

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.

サイズ 価格(税別)  
JPY 19422.00
JPY 78020.00

カスタマーフィードバック(4)

  • After treatment with 1.5 g/l matrine in the presence or absence of 10 nM Baf A1 or 20 nM rapamycin or 10 lM z-VAD-FMK (zVAD) for 24 hrs, the cell viability was measured by CCK-8 assay. Results were expressed as mean±S.E.M. representing at least three independent experiments. *P < 0.05, versus matrine alone group.

    J Cell Mol Med, 2017, 21(6):1171-1181. Z-VAD-FMK purchased from Selleck.

    (A and B) Western blot analysis examining the effect of zVAD-fmk on the icaritin-induced apoptosis. The caspase inhibitor zVAD-fmk could significantly decrease the icaritin-induced cleaved caspase-3 expression. β-Actin protein levels indicate that an equal amount of protein was loaded into each lane.n=3. Mean±SD. bP<0.05, compared to the control group. eP<0.05, compared to the icaritin-treated group.

    Acta Pharmacol Sin 2014 35(4):531-9. Z-VAD-FMK purchased from Selleck.

  • Active caspase-3 expression analysis. SW1116 cells were treated with ZBH-1205, CPT-11 and SN38 at 25 μmol/L for 48 h, in the presence or absence of Z-VAD-FMK (50 μmol/L, 1 h ahead of time). *P= 0.0345. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). E: Cell cycle analysis. F: Apoptosis analysis. #P=0.0259. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). ALL experiments were repeated three times.

    Arch Biochem Biophys, 2016, 604:74-85.. Z-VAD-FMK purchased from Selleck.

    Effect on the RAS of CFZ, z-VAD-fmk, or CFZ + z-VAD-fmk treatments administered 5 or 12 days after C26 inoculation and control groups. Western blot analysis of ATF2 and pATF2. CP, ZP and UP were treated for 5 days; CT, ZT, UT and CC were treated for 12 days. CFZ (CP), z-VAD-fmk (ZP), CFZ + z-VAD-fmk (UP), PBS only (CC), healthy control (HC).

    Med Oncol, 2015, 32(4): 538 . Z-VAD-FMK purchased from Selleck.

製品安全説明書

Caspase阻害剤の選択性比較

生物活性

製品説明 Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.
特性 A key compound for apoptosis studies.
ターゲット
Pan-caspase [1]
(THP.1, Jurkat T-cells)
体外試験

Z-VAD-FMK (10 mM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK (10 mM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells. [1] Z-VAD-FMK (50 μM) cotreatment abolishes the apoptotic morphology of camptothecin-treated HL60 cells. Z-VAD-FMK (50 μM) blocks camptothecin-induced DNA fragmentation in HL60 cells. [2] Z-VAD-FMK (50 μM) inhibits cell death following dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK (50 μM) increases the percentage of transfected cells surviving from 26% to 63% in S2 cells. [3] Z-VAD-FMK (> 100 μM) enhances TNFα-induced neutrophil apoptosis, lower concentrations (1-30 μM) completely blocks TNFα-stimulated apoptosis in human neutrophils. [4] Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes. Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes detected with the TUNEL assay. [5]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
GC1a MVrBdI9xfG:|aYOgRZN{[Xl? MXq1NO69VQ>? MXmyOIg> NYPOVZF{cW6maXPheIV{KGFicILveIVkfGm4ZTDl[oZm[3RiYXfhbY5{fCCndH;wc5Nq\GV? M2XDR|I3OTZ7MEe1
HGL5 NX6yfYRsSXCxcITvd4l{KEG|c3H5 MlH2OVDPxE1? MYeyOIg> NVXPXIxHcW6maXPheIV{KGFicILveIVkfGm4ZTDl[oZm[3RiYXfhbY5{fCCndH;wc5Nq\GV? NFn5VpUzPjF4OUC3OS=>
HepG2 M2XF[GFxd3C2b4Ppd{BCe3OjeR?= M1PWV|Ix|ryP NXLpPYJ6OWh? MlnZZZR1\W63YYTl[EB1cGViYYDvdJRwfGmlIHnu[JVkfGmxbjDv[kBKUUlvMUFCpC=> MXeyOlE3PDd7NR?=
BEL-7402 MlLuRZBweHSxc3nzJGF{e2G7 M2PqN|Ix|ryP NWHsUGI1OWh? NUK3W3pV[XS2ZX71ZZRm\CC2aHWgZZBweHSxdHnjJIlv\HWldHnvckBw\iCLSVmtNVDDqA>? NVTjXVJYOjZzNkS3PVU>
CEF NVvvc25CU2mwYYPlJGF{e2G7 NEPncmExNDN|LE[3MFExOM7:TR?= MXixOY1qdg>? M12wW4Rwf25vcnXneYxifGW|IGDSJIVvgnmvZTDhZ5Rqfmm2eTD0c{A1OO,:hTDheEAyODEQvF2= MnXYNlYyODJ|M{m=
SP2/0 NWDjVFFwSXCxcITvd4l{KEG|c3H5 MXOxNFDPxE1? MnriNYg> Ml74SG1UVw>? NWD6Z2l{[myxY3vzJJRp\SCjcH;weI9{cXNib3[gV3AzNzBiY3XscJM> M2DNc|I3ODd2N{Oy
HUVEC-2c MXvBdI9xfG:|aYOgRZN{[Xl? NYrBcY52PTEQvF2= MoPXOog> MV7k[YNz\WG|ZXSgeIhmKG:6LVzEUE1qdmS3Y3XkJIF2fG:yaHHnfS=> MX:yOlAzOTd{OR?=
U1 M1\CTGFxd3C2b4Ppd{BCe3OjeR?= NXm2fmwzOC1zMEFOwG0> MX:ybC=> MX3y[YR2[2W|IHTyeYcucW6mdXPl[EBieG:ydH;zbZMh[W6mIIP1ZpNmeXWnboSgTGlXNTFicnXwcIlk[XSrb36gbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= NYj2cJkxOjV7OEC5OFI>
ACH-2 M1jBfmFxd3C2b4Ppd{BCe3OjeR?= NY\2N446OC1{MEFOwG0> NUHVN4VpOmh? Mk\YdoVlfWOnczDkdpVoNWmwZIXj[YQh[XCxcITvd4l{KGGwZDDzeYJ{\XG3ZX70JGhKXi1zIILldIxq[2G2aX;uJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy MWOyOVk5ODl2Mh?=
U1 M3frfmtqdmG|ZTDBd5NigQ>? Mkj6NVAx|ryP MoXsNog> M1nsR4lvcGmkaYTzJINie3Cjc3WtNy=> NVzmZY02OjV7OEC5OFI>
A549/V16 NU\0c2xSSXCxcITvd4l{KEG|c3H5 NYPYZ5ByPTEQvF2= NVjRWHdsOWh? NIj3Xo9z\XC{ZYPz[ZMhXEdxVF2tbY5lfWOnZDDhdI9xfG:|aYO= M1HwOVI2QTR4MEOz
SGN NVT6e3NPSXCxcITvd4l{KEG|c3H5 NV3nbWxEOjCvTR?= MV20PIg> Mn3ObIF{KG6xIHnu[ox2\W6lZTDvckBCUUZuIHPhcJBicW5iZYjwdoV{e2mxbjDvdkBk\WyuIHHwc5B1d3Orcx?= NIHPXGczPTh5NE[zNy=>
HCT116  NFu0S5JCeG:ydH;zbZMhSXO|YYm= MUe1NO69VQ>? NX7PRYRsOmh? NGG2e|lqdmirYnn0d{B1cGViY3XscEBl\WG2aDDpcoR2[2WmIHL5JGRFXlB? Mn7FNlU5Pjh6MUi=
DTK-SME NIDaPGxCeG:ydH;zbZMhSXO|YYm= MlPKOVDPxE1? MnW4Nog> NG[5PHlFVVOR MoTpdIFzfGmjbHz5JIlvcGmkaYTzJJRp\SCjcH;weI9{cXNiaX7keYNm\CCkeTDieZBqfmGlYXnu[S=> MlPoNlU5PDN6OUe=
HL-60 NIOxZXdCeG:ydH;zbZMhSXO|YYm= Mo[xOVDPxE1? MXy0PIg> MXfy[YR2[2W|IHPlcIwh\GWjdHigZ4F2e2WmIHL5JHNMUS2LSTD0doVifG2nboVCpC=> MVeyOVgzPDB2Mx?=
U937 NXGwPGpOSXCxcITvd4l{KEG|c3H5 NIj2[mg2OM7:TR?= MnLqOFhp NFXyT3dz\WS3Y3XzJINmdGxiZHXheIgh[2G3c3XkJIJ6KFONST3JTUB1emWjdH3lcpTDqA>? M2rvNVI2QDJ2MESz
A549 Ml24RZBweHSxc3nzJGF{e2G7 MX:yNEDPxE1? MWeyOIg> MXzy[YR2[2W|IHPlcIwh\GWjdHigZ4F2e2WmIHL5JGhHS1BidILlZZRu\W62 MYqyOVc6PDF2OR?=
HeLa M2jTTWFxd3C2b4Ppd{BCe3OjeR?= MlTtNVDPxE1? MXu0PIg> NGPrU2Vl\WOuaX7ld{B1cGVicnH0[UBw\iCjcH;weI9{cXNiZILhcYF1cWOjbHz5 NVHZdHdDOjV5N{K1OFU>
SGC-7901 MU\BdI9xfG:|aYOgRZN{[Xl? NGWyT3czOMLizszN NFz2UlQycA>? MVfpcohq[mm2czD0bIUh[2WubDDk[YF1cCCrbnT1Z4VlKGK7IH;4ZYxqeGyjdHnu NHjKWY8zPTd4N{C3Oi=>
MCF-7 MY\BdI9xfG:|aYOgRZN{[Xl? MkTpNVDPxE1? M3HKVFJp NUP4PJhncW6qaXLpeJMhfGinIHPlcIwh\GWjdHigbY5lfWOnZDDifUA{Sg>? MYmyOVczOjFzNB?=
A549 MWfBdI9xfG:|aYOgRZN{[Xl? NUHnOZVPOTBizszN NYPISJpbOjSq NUOxU4tCTE2VTx?= MXnwdo9ud3SnczDIRmMufHKnYYTl[EBCPTR7IHPlcIwhe3W{dnn2ZYwhLiCjdITlcpVifGW|IITo[UBkdGWjdnXkJHBCWlBiZYjwdoV{e2mxbh?= NXnWUpJ{OjV4OEO1Olg>
U87 Ml\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU[1NO69VQ>? MYqxbC=> NUXKVodGemWlb4\ldpMh[2WubDDndo94fGhiZoLvcUBVVVpidILlZZRu\W62 MoG5NlU3QDF4Nki=
Neocortical Neuron NV3LflJlVmW3cn;0c5hq[2m2eTDBd5NigQ>? NXLw[mdbOTByzszN MVixbC=> MWPhcpRi\2:waYrld{BJd2mjbXnk[UBCNUmwZIXj[YQhVmW3cn;0c5hq[2m2eR?= NH;KNY0zPTZ5NUCwNS=>
Primary human placental cytotrophoblasts MWjBdI9xfG:|aYOgRZN{[Xl? NGewfYE{OM7:TR?= M{\lXFI1cA>? NVXmRVB6TE2VTx?= MnrFdoV3\XK|ZYOgeIhmKGmwaHnibZRqd25ib3[gNVHPui2KU1SyJIJ6KHS{aXPsc5NidsLi M3;l[FI2PjR{NUmy
MM NFXx[WJCeG:ydH;zbZMhSXO|YYm= MoPjOVDPxE1? Ml3QNlBucW5? MoHPdIFzfGy7IHnubIljcXS|IGPIT{1qdmS3Y3XkJEBk\WyuIHTlZZRp NVLq[GQzOjV3M{CwPVg>
DLD1 MlW3RZBweHSxc3nzJGF{e2G7 M1nvWlIxyqEQvF2= NYezWW5SOWh? Mn;tdIFzfGy7IILleoVze2W|IHPlcIwh[XCxcITvd4l{KGOjdYPl[EBjgSCZU2Cx NE\UXJkzPTV{NEK0Oi=>
MDA-MB-231 NVrEOndDS3m2b4TvfIlkcXS7IFHzd4F6 M1;DTlEx|ryP NX7tOoZEOWh? NF25S3JifWevZX70d{Bk\WyuIHTlZZRpKGGodHXyJGNJXUFidILlZZRu\W62 M4r0S|I2PTJzNUCx
MKN28 MkXrRZBweHSxc3nzJGF{e2G7 NXLLd5dVOTEQvF2= MkK0N|BucW5? M2e2e2ROW09? MXXpcohq[mm2czDUUmYu|rFicHz1d{BEUFhvaX7keYNm\CCjcH;weI9{cXN? M1\6SVI2PTF|OU[w
HL-60 NEPBOVBEgXSxdH;4bYNqfHliQYPzZZk> MUWxNFDPxE1? Mlj1NYg> NX3pSGFiTE2VTx?= MXpCpIlueHKxdnXzJJZq[WKrbHn0fUBw\iCWQ17Bd{11emWjdHXkJINmdGy| M3jhcFI2PTB{OUOy
AGS NUfwZ4pQSXCxcITvd4l{KEG|c3H5 NF3HVYoyOM7:TR?= NFi2TW8ycA>? NXftN4tGeHKndnXueJMh[3W{Y4XtbY4ucW6mdXPl[EBkdGWjdnHn[UBw\iClYYPwZZNmNTNuID24MEBidmRiLUmgdJJwfGWrboO= MoLDNlU1QTJ{MUS=
A549  MmSwRZBweHSxc3nzJGF{e2G7 M4TtXFEx|ryP NX:3RVRYOjSq M2PYd4Jtd2OtczDEUWFUNWmwZIXj[YQh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|IHHu[EBRSVKSIHHu[EBieG:ydH;0bYMh[2WubDDk[YF1cA>? NXf6VZZ{OjV2M{S5PFk>
INS-1 Mly1RZBweHSxc3nzJGF{e2G7 NFjsWHQ2OM7:TR?= NUPQSXJFPmh? NVL0VYVHTE2VTx?= NFrHOGZl\WO{ZXHz[ZMhfGinIIDyc5BwenSrb36gc4Yh\WG{bImgZZBweHSxdHnjJINmdGy|wrC= NXvsbVdlOjV2M{C4PVc>
Primary hepatocytes  MX7BdI9xfG:|aYOgRZN{[Xl? NEnrOnE2OM7:TR?= MkKwNVhp MX7pcohq[mm2czDhdI9xfG:|aYOgc4YhcGWyYYTvZ5l1\XNiaX7keYNm\CCkeTDBZ5QhTCCjbnSgWG5HNc7z NIHT[GMzPTRyN{WzPC=>
L929-A  NEOxUZNEgXSxdH;4bYNqfHliQYPzZZk> MYCyNOKh|ryP NWjSbnh6OjSq NIGzR2FqdmirYnn0d{BVVkcQsT3pcoR2[2WmIHPlcIwh\GWjdHi= Mn3uNlU{QTh3NEC=
L929-N MY\DfZRwfG:6aXPpeJkhSXO|YYm= MlrENlDDqM7:TR?= M3PSS|I1cA>? NXXNd4Nq\W6qYX7j[ZMh\GWjdHigeoliKGG3dH;jdolv\SCWTldOtUBxem:mdXP0bY9v NFe0dIgzPTN7OEW0NC=>
Cytotoxicity Assay M{\QVmNmdGxiVnnhZoltcXS7IFHzd4F6 NX7BTlFMOjEQvF2= NILRdJU1QGh? NUnKUZB[eHKndnXueEBOUE2GLXnu[JVk\WRiY3XscEBl\WG2aB?= MnTvNlU{QTJzMU[=
COS7 NX25bZFVU2mwYYPlJGF{e2G7 M13SdVEx|ryP NXTpSHJrOjSq M3XCWYlv[3KnYYPld{Bk[XOyYYPlJFMwPyCjY4Tpeol1cWW| MmT6NlU{QDRyMkW=
COS7 NFfweJlCeG:ydH;zbZMhSXO|YYm= M{XpfFEx|ryP MnmxOFhp MX\wZZJ1cWGubImgdJJmfmWwdHXkJGZEOTBzLXnu[JVk\WRiY3XscEBl\WG2aB?= NWrqNVlHOjV|OESwNlU>
A375 M2j4ZWFxd3C2b4Ppd{BCe3OjeR?= MYGzNO69VQ>? M{HaS|Jp MVLwdoV3\W62czD0bIUh\HK3Zz3pcoR2[2WmIGDBVnAh[2ynYY\h[4U> NIrGemgzPTN5NkGxOS=>
A549 M4\6c2Fxd3C2b4Ppd{BCe3OjeR?= NVPL[IFtPTEQvF2= NVHkWpFNOjSq MVXy[ZZmenOnczDybYJwe2:vZTDibY9o\W6nc3nzJIFv\CCjcH;weI9{cXNiY3H1d4VlKGK7IDDDbIlrd26pZHHu M2fMZlI2OzR7N{ix
A549 MnTBRZBweHSxc3nzJGF{e2G7 MlLjNk42NTJ3zszN M1TuTVFp NFPYPWZl\WO{ZXHz[ZMhfGinIIDvdJVt[XSrb36gc4Yh[XCxcITveIlkKGOnbHzzJIRmeGWwZDDvckBkd26lZX70doF1cW:wcx?= M3PKS|I2OzR{NEK3
 NBL-W-S  MVrBdI9xfG:|aYOgRZN{[Xl? NVXaUZR7PTEQvF2= M1TzVlFp NYe5T2N1\nWubImgdoV{[3WnczDj[YxtKH[rYXLpcIl1gSCjZoTldkBISU6WLU[xJJRz\WG2bXXueC=> M1[3RlI2OzJ|MkKy
Caki-1  NETYdHRCeG:ydH;zbZMhSXO|YYm= NYT6bHF6PDEQvF2= MXO0PIg> NVrEUplIemWmdXPld{B1cGViboXtZoVzKG:oIFHucoV5cW5iVj3wc5NqfGm4ZTDj[Yxtew>? NIewbY8zPTJ5OUG5NS=>
769-P Mo[wRZBweHSxc3nzJGF{e2G7 Mn2yOFDPxE1? MoTTOFhp NFH4fZNz\WS3Y3XzJJRp\SCwdX3i[ZIhd2ZiQX7u[ZhqdiCYLYDvd4l1cX[nIHPlcIx{ Mlu5NlUzPzlzOUG=
H9c2 NHPqd25CeG:ydH;zbZMhSXO|YYm= MlHEOVDPxE1? M{\LZlFp NIrpXJJqdmirYnn0d{BFV1hvaX7keYNm\CClYYPwZZNmKDNiYXP0bZZifGmxbjDieZQhdm:2IITo[UBtd3O|IH;mJINmdGy| MnrjNlUzQDN6MUm=
K562 M{TyN2Fxd3C2b4Ppd{BCe3OjeR?= MWO1NO69VQ>? M{\Cb|Rp MWfpcohq[mm2czDKZYMuSS2rbnT1Z4VlKGOnbHygZZBweHSxc3nz MlTaNlUzPDF4MUm=
L929 NV\zdZhLSXCxcITvd4l{KEG|c3H5 MoD1NVDPxE1? M3HNeVZp NYXue2JlcW6mdXPld{Bv\WO{b4D0c5NqeyC5aYToJHRPTg>? NE\RWpQzPTF7NU[2NC=>
A549 NWKw[o17SXCxcITvd4l{KEG|c3H5 Mn3PNVDPxE1? MX:zbC=> NGTjdWVz\WS3Y3XzJINmdGxiYYDvdJRwe2m|IHPheZNm\CCkeTDQVXE> NVG3[HN5OjVzNkG2PVk>
MCF-7 NHzzeoFCeG:ydH;zbZMhSXO|YYm= MkPnNlDPxE1? NV3ERZZsOmh? M2jWWYRm[3KnYYPld{BMTFJvc3nSUmEucW6mdXPl[EBieG:ydH;zbZM> NFjhdHEzPTF6MkK0NC=>
OS NXnvdYkySXCxcITvd4l{KEG|c3H5 NEXSNIozOC92MN88US=> M{nEflczcA>? MVTpcohq[mm2czDPV{Bk\WyuII\pZYJqdGm2eTDy[YR2[3Srb36gZpkhSzZiY3XyZY1q\GV? M{PFVVI2OTV{M{m5
HUVECs M1jnZWFxd3C2b4Ppd{BCe3OjeR?= Mk\vNVDPxE1? M3vWT|Jp Ml6wxsBqdmirYnn0d{BieG:ydH;zbZMh[W6mIH\hZ4ltcXSjdHXzJIF2fG:yaHHnfUBqdiCGRV7WNk1qdm[nY4Tl[EBJXV[HQ4O= NVvOOHJWOjVzM{i3NFM>
EA.hy926 NUnvOIlSSXCxcITvd4l{KEG|c3H5 MnTZNVDPxE1? MWWybC=> NWCzcZZPyqCrbnjpZol1eyCjcH;weI9{cXNiYX7kJIZi[2muaYTheIV{KGG3dH;wbIFogSCrbjDESW5XOi2rbn\lZ5Rm\CCHQT7ofVkzPg>? Mo\RNlUyOzh5MEO=
Ebs NVTWOVl5SXCxcITvd4l{KEG|c3H5 NWXJWJVTOTBvMUCw{txO MlfmNlRp NW\EZ4dMyqCPTWTTJIdmdmW{YYTpc44hemG2ZTDk[YNz\WG|ZXSgZZMhfGinIHPvcoNmdnS{YYTpc44hd2Ziej3WRWQv\m2tIHnuZ5Jm[XOnZB?= MlzENlUyOzR6MUe=
Jurkat NFP5[4dCeG:ydH;zbZMhSXO|YYm= NXXVUY96OjEQvF2= MnjONlRp Mm\vSG1UVw>? NXj6epdieGG{dHnhcIx6KGmwaHnibZQh[2WubDDk[YF1cCCxZjDKeZJs[XRiY3XscJMhcW6mdXPl[EBjgSBzMEC1PE1HPCClb33ibY5m\CC5aYToJHZRScLi M{fkNlI2OTJyN{Kz
K562 NVHYWJRWSXCxcITvd4l{KEG|c3H5 MmexNE4yNTIQvF2= M1n5PVFp Ml\NbY5pcWKrdIOgZ4xm[X[jZ3Wgc4YhUFOSOUCgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= NETjRoMzPTFzOUG4PC=>
IMR-32 MmnQRZBweHSxc3nzJGF{e2G7 MnrVOFDDqM7:TdMg NF3hcJIzcA>? MVrk[YNz\WG|ZTDpckBieG:ydH;0bYMh[2WubIOgZ49ueGG{ZXSgeI8hXC1{IITvfIlv MVyyOVA5PDd3NR?=
RPMI 8226 MonHRZBweHSxc3nzJGF{e2G7 MX:xNFDPxE1? NGqyWWcycA>? NXjBN|lv[Wyvb4P0JINwdXCuZYTlcJkh[myxY3vzJINmdGxiZHXheIgh[2G3c3XkJIJ6KG6nY4Lvd5RifGmwLUG= MkTPNlUxOzd6NUG=
U266  MkjrRZBweHSxc3nzJGF{e2G7 MlfyNVAx|ryP MoXENYg> M1TaVZBienSrYXzsfUBjdG:la4OgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhdmWlcn;zeIF1cW5vMR?= NGLkelkzPTB|N{i1NS=>
H929  NXLYXFY{SXCxcITvd4l{KEG|c3H5 NWPtWpRCOTByzszN Ml7GNYg> MUfwZZJ1cWGubImgZoxw[2u|IHPlcIwh\GWjdHigZ4F2e2WmIHL5JI5m[3Kxc4TheIlvNTF? NUDVRXFmOjVyM{e4OVE>
MM.1S  MYDBdI9xfG:|aYOgRZN{[Xl? NF;td4MyODEQvF2= MoLpNYg> NUjyfnVK\W[oaXPp[Y51dHlicILleoVvfHNic3;yZYZmdmmkLXnu[JVk\WRiY3XscEBl\WG2aDDjc41jcW6nIIfpeIghdmWlcn;zeIF1cW5vMR?= MkDxNlUxOzd6NUG=
C6 MYDBdI9xfG:|aYOgRZN{[Xl? M2WyOlUx|ryP M{fz[|Q5cA>? M2XaUZBz\X[nboTzJJRp\SCub4PzJI9nKGOnbHygeoli[mmuaYT5JINifXOnZDDifUBxemWpbnXuc4xwdmV? Mn;INlUxOTN2N{m=
AGS NXnUfWpQSXCxcITvd4l{KEG|c3H5 Mo\oOVDPxE1? NFnYT|MzPGh? NWK5OlhX[WKxbHnzbJMh|rJvbHHwZYNpd26nLXnu[JVk\WRiY3XscEBl\WG2aDDhcoQhcW6qaXLpeIVlKGe{b4f0bC=> MoS0NlUxODl4OUi=
HeLa  Mof4RZBweHSxc3nzJGF{e2G7 M{nrflQx|ryP NIW1UFMzPGh? Mni0bY5pcWKrdIOgeIhmKGmwY4LlZZNm\CCjcH;weI9{cXNiaX7keYNm\CCkeTDzbXJPTjF{MR?= Ml7nNlQ6Ojh4OEW=
THP-1  NHHi[YhCeG:ydH;zbZMhSXO|YYm= NX7PV2ZXOTEQvF2= NITpRosycA>? NFfvNpRz\WS3Y3XzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KEGOQT3TSHTDqA>? Mn;ONlQ6OjN4NUO=
P815  NVOwS2VRSXCxcITvd4l{KEG|c3H5 MU[xNFAhyrWP NEHMPHkyOmh? M1P5dWROW09? MXTpcohq[mm2czD2bZJ2ey2rbnT1Z4VlKGGyb4D0c5Nqew>? MoX4NlQ6OjN{N{O=
HCT116 MXjBdI9xfG:|aYOgRZN{[Xl? MoHnNlDPxE1? M3O1O|I1cA>? NY\sOmh7[WK{b3fheIV{KG:oIGTRMYlv\HWlZXSgZZBweHSxc3m= NGXob2kzPDh7MES0PS=>
SW1116  MVHBdI9xfG:|aYOgRZN{[Xl? M1zj[|ExKML3TR?= MYKxbC=> NF62NItFVVOR MmDKdoV{fHKjaX7zJINmdGxiYYDvdJRwe2m|IHnu[JVk\WRiYomg[4VncXSrbnniJJBtfXNiZHXjbZRi[mmwZR?= MWSyOFg4PDJ6Nh?=
LOVO NYmxU|FzSXCxcITvd4l{KEG|c3H5 M4DtZlExKML3TR?= M{fGSlFp MWLEUXNQ MorVdoV{fHKjaX7zJINmdGxiYYDvdJRwe2m|IHnu[JVk\WRiYomg[4VncXSrbnniJJBtfXNiZHXjbZRi[mmwZR?= M{PhWlI1QDd2Mki2
SNU449  M17HUWFxd3C2b4Ppd{BCe3OjeR?= M4LsNVIx|ryP NHvUZoE1QGh? NHL0PYtFVVOR MYPk[YNz\WG|ZYOgcYlTNTR3MT3pcoR2[2WmIHHwc5B1d3SrYx?= NYDydodjOjR6NEG2N|g>
Caco-2 NUP3XG57SXCxcITvd4l{KEG|c3H5 NWLTV3hnPDEkgJpOwG0> NFn5RZQ1cA>? NFzuV2xxemW4ZX70d{BUXC15LXnu[JVk\WRiWl:tNUBkcGGwZ3XzJIFv\CCWRWKg[JJweA>? M1fNSlI1QDJ{MUiz
macrophage MkfnR4VtdCCYaXHibYxqfHliQYPzZZk> Ml;WNE0zODEQvF2= NInNPJgzPGh? Mn\GbY5lfWOnczDUUmYuKGGwZDDSbZA{NWSncHXu[IVvfCCwZXPyc5B1d3OrczDpckBu[WO{b4DoZYdm NGCzXIQzPDd7OUW2OS=>
AGS  M3vhbGFxd3C2b4Ppd{BCe3OjeR?= NXHoXJdOOjEQvF2= MYqxNog> Ml7uSG1UVw>? M3;KTJJm\HWlZYOgeIhmKGmwZIXjeIlwdiCxZjDhdI9xfG:|aYOgbY4hemW|cH;ud4UhfG9idHjlJGV1V0GlIH\yZYN1cW:wIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ MmO0NlQ4QDl5MEO=
LCC9  M4TsUWNmdGxiVnnhZoltcXS7IFHzd4F6 MkTFNVAx|ryP MnfJOYQ> NYD5cpA4[myxY3vzJINmdGxiZHXheIghcW6mdXPl[EBjgSClb33ibY5ifGmxbjDMNVch[W6mIHPocI9zd3G3aX7l NHjnd5UzPDd6NUK1Oi=>
U937  M2DVVI5m[3KxcITvd4l{KEG|c3H5 NX\lfXpYOTEEoN88US=> NWD3d3RDOzEEoH3pci=> MXfpcoR2[2W|IH7lZ5JweHSxc3nzJINwdWKrbnWge4l1cCCWTl[= Ml;2NlQ4PzN5NU[=
T cell NUXheJY1S2WubDDwdo9tcW[ncnH0bY9vKGG|c3H5 NYrYOItWOC1zMEFOwG0> Mmr0O|Jp Mnq5TWM2OD15MDFOwG0tKGmwaHnibZR{KGGwdHmtR2Q{NWmwZIXj[YQhXCClZXzsJJBzd2yrZnXyZZRqd25iaX6gVGJOS3N? NGLXO5MzPDd4OEewOy=>
HeLa  NUnsZYlSSXCxcITvd4l{KEG|c3H5 MmjlOVDPxE1? MUC3Nog> MXrEUXNQ NGHqT2pxemW4ZX70d{BieG:ydH;zbZMhcW6mdXPl[EBjgSClb33wc5Vv\HQEoEJihLM2 M4joNFI1PzV2N{i2
HeLa  MUjBdI9xfG:|aYOgRZN{[Xl? MX6xNFDPxE1? NEL3OJgzPGh? MVvzeZBxemW|c3XzJJJifGVib3[gZ4VtdCCmZXH0bEBqdmS3Y3XkJIJ6KG:4ZYLlfJBz\XO|aX;uJI9nKEd3OWOgc5IhTzdzUjDwNVUx\2y3ZXVCpC=> NHfDNlQzPDd{MkS2PC=>
IEC-6  NGDvNYVCeG:ydH;zbZMhSXO|YYm= MmPONVDPxE1? NEHpcIwzPGh? MWDwdoV3\W62czDUZ4RCNWmwZIXj[YQh[2G|cHHz[U0{KGOuZXH2ZYdmKGGwZDFOtk1k[XSnbnnuJIRm\3KjZHH0bY9v M3jJN|I1PzFzNUex
HCT116 MUPBdI9xfG:|aYOgRZN{[Xl? NVPSUXlROjEQvF2= NXzDTmd1OjSq MoHJbY5pcWKrdIOgeIhmKGOnbHygZZBweHSxdHnjJIlv\HWlZXSgZpkhYUyWMkC1 NEXEfVQzPDdzM{ixNi=>
L02 MV;BdI9xfG:|aYOgRZN{[Xl? NFKyRlQzOM7:TR?= Mo\MNYg> MmfBdJJmfmWwdIOgeIhmKGOnbHygZZBweHSxc3nzJIlv\HWlZXSgZpkhVUWKUB?= NIPSOWkzPDdyNkS2NS=>
A375 M2q4dWFxd3C2b4Ppd{BCe3OjeR?= MmW3NlDPxE1? MVSyOIg> MUDy[ZZmenOnczDkbYNqfHKrbn;u[UBDNWmwZIXj[YQh[XCxcITvd4l{ MVmyOFY6QTFzMR?=
HDPC M{fqcWFxd3C2b4Ppd{BCe3OjeR?= NULmSYVQPTEEtV2= MnvkNlRp M1\6d4lvcGmkaYTzJG5QNWmwZIXj[YQh[XCxcITvd4l{ MUmyOFY{PDV7Mx?=
A549 NF\pfGlCeG:ydH;zbZMhSXO|YYm= M2DsU|UxyrWP NInz[5AzcA>? NYPVcJJiTE2VTx?= NVn4bmFxeHKndnXueJMhfGinIHj5dI9lcXCub3nkJGRPSSClb370[Y51KHCqYYPlJIlv\HWlZXSgZpkh[2WyaHHsc4Npem:vaX6= NX;pcINJOjR3OEixN|U>
 BV-2 NE[2VYtCeG:ydH;zbZMhSXO|YYm= MUeyNO69VQ>? Mn7ENog> NITEVGl{fXCycnXzd4V{KFWYLXnu[JVk\WRiY3jyc41ifGmwIHX4eJJ2e2mxbjDhcoQh\GmuYYTpc44hd2ZidHjlJI52[2ynYYKg[Y53\WyxcHW= NYPaZ4FQOjR3NUixNVg>
HT-29  M3ezdmFxd3C2b4Ppd{BCe3OjeR?= NGHTO482OM7:TR?= M322NlQ5cA>? MV3icI9kc3NidHjlJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KGujZX3w[oVzd2x? NIjWeJMzPDV2OUG3OS=>
A549 MXjBdI9xfG:|aYOgRZN{[Xl? NV3t[HJWPc7:TR?= NX\Td3pYOjSq NHq1XmR{fXCycnXzd4V{KD[nwrCoRmsyODB2MDmtbY5lfWOnZDDhdI9xfG:|aYRCpC=> NGOyVWczPDV{OUi3NS=>
MIA-PaCa-2 M4WwcGFxd3C2b4Ppd{BCe3OjeR?= Mnn2NlRp MVjicI9kc3NiY3zlZZZi\2Vib3[gZ4F{eGG|ZT2zJIlv\HWlZXSgZpkh[m:2aDDBMVQ1OzZ3NDDhcoQheGGlbHn0ZZhmdA>? MX6yOFUyODl7Mh?=
Caki-1 MWLBdI9xfG:|aYOgRZN{[Xl? NXHuW|VWOjEQvF2= MluxNYg> M1Xj[IlvcGmkaYTzJHNEWC2rbnT1Z4VlKGGyb4D0c5Nqew>? M2Djc|I1PTB2Nkix
CLL MXTBdI9xfG:|aYOgRZN{[Xl? MlLtNlXPxE1? NXjHTm9{OWh? NH7CPIJx[XK2aXHscJkh[myxY3vzJG1NVjJ{M{itbY5lfWOnZDDj[YxtKGGyb4D0c5Nqew>? MXyyOFQ3PzZ|NB?=
SGC-7901 M3vrZWFxd3C2b4Ppd{BCe3OjeR?= Mly2NVDPxE1? MnjpNlRp MV\wdo9ud3SnczD0bIUhS0eLST3pcohq[mm2ZXSgZ4VtdCCpcn;3eIghcW5iU1fDMVc6ODFiY3XscJM> M{jnT|I1PDV2NEi4
k1735 MXTBdI9xfG:|aYOgRZN{[Xl? NV;kO4VvOjEkgJpOwI0> NYjOSJo3PGh? MXXpcohq[mm2c9MgV4FtdW:wZXzsZU1qdmS3Y3XkJIFxd3C2b4Ppdy=> NIrDPYwzPDR3MUGxOi=>
HaCaT  MWHBdI9xfG:|aYOgRZN{[Xl? MU[xNFDPxE1? MW[xbC=> Mk\vZox2dnS|IGXWRk1qdmS3Y3XkJIFxd3C2b4Ppd{BqdiCKYVPhWEBk\Wyucx?= NFzUR40zPDN3Nkm5Oy=>
podocytes MnXORZBweHSxc3nzJGF{e2G7 NVXRdGZJOjByzszN M{m3N|Zp NWHqdItDcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliMzy0MWRITQ>? M1OzVFI1OzN5N{e3
 KB NIniV3VCeG:ydH;zbZMhSXO|YYm= NEHuc4U2OM7:TR?= NHjPO4wzPGh? M1rO[YlvcGmkaYTzJGxq[29vQT3pcoR2[2WmIHPhd5Bie2VvMzDhcoQhWEGUUDDhZ5RqfmG2aX;u NFeyNmkzPDN|N{S5Ni=>
 HepG2  M3XtNWFxd3C2b4Ppd{BCe3OjeR?= M{jlXlEx|ryP NVnjWG5lOjSq NVTwO5JMemWmdXPld{B3cW2nboTpckBkdGWjdnHn[UBk[XW|ZXSgZpkhVFCV M3PJdlI1OzJ3OEG2
fetal rat lung fibroblasts  MnjzT4lv[XOnIFHzd4F6 NWrBSmxtQDEQvF5CpC=> M33yWlFp NVTCU5h2cW6qaXLpeJMhS2G|cHHz[U0{KGGldHn2bZR6yqB? MYeyOFMyPDF|NR?=
PDL fibroblasts NFzGZndMcW6jc3WgRZN{[Xl? NV:xOVk3QDEQvF5CpC=> MlywNYg> M1;MbIlvcGmkaYTzJGNie3Cjc3WtN{Bi[3Srdnn0feKh MnX2NlQ{OTRzM{W=
MB49 MmXERZBweHSxc3nzJGF{e2G7 NXzpNm86OjEQvF2= NEHtbZoycA>? MUHy[ZZmenOnczDDUU1qdmS3Y3XkJINmdGxiZHXheIg> M37mOVI1Ojh{NEOz
5637 NHHwfmhCeG:ydH;zbZMhSXO|YYm= NGrmfWszOM7:TR?= M3HzNVFp M4jFZ5JmfmW{c3XzJGNONWmwZIXj[YQh[2WubDDk[YF1cA>? NWXWeXF2OjR{OEK0N|M>
A549  NWTJW3NOSXCxcITvd4l{KEG|c3H5 M17JTVExOM7:TR?= NHXOXGc1QGh? NVnReWhie3WycILld5NmeyC2aHWgZZBweHSxc3nzJINifXOnZDDifUBxcXCncnnu[eKh NYDMSVVnOjR{N{KyNFE>
MCC-2 NGnOT2VCeG:ydH;zbZMhSXO|YYm= MkTTNlAh|ryP M{XVUlZp MVrEUXNQ MlfEZoxw[2u|IHnu[JVk\WRiYomgd5RifXKxc4Dvdolv\SCjcH;weI9{cXNiY3XscEBl\WG2aB?= MoLnNlQzPjJ4NUi=
ADF NGL2[3lCeG:ydH;zbZMhSXO|YYm= M4LT[FQx|ryP NUDjXlFqPmh? MWPpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkcGWvb4To[ZJieHlicHz1d{BbdkOuMh?= MX[yOFIzQDJ|Mh?=
 U373  M1jSbGFxd3C2b4Ppd{BCe3OjeR?= MnfMOFDPxE1? M4\UPVZp NVfydHhGcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliY3jlcY91cGW{YYD5JJBtfXNiWn7DcFI> NFGwNWwzPDJ{OEKzNi=>
RKO-HIPK2i MVXBdI9xfG:|aYOgRZN{[Xl? NYHBbIZYPDEQvF2= MmraOog> MoLnbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkh[2inbX;0bIVz[XC7IIDseZMhYm6FbEK= MYqyOFIzQDJ|Mh?=
HEC-1B NH\ZUodCeG:ydH;zbZMhSXO|YYm= NXvOWodWOjEQvF2= NFzZfnUycA>? MYny[YR2[2W|IGTQMYlv\HWlZXSgZZBweHSxc3nzxsBk[XOyYYPlMVMh[W6mIHPhd5Bie2VvOR?= NILGXZkzPDJzM{O1PC=>
4T1 NFLmdIFE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MVOyMlUuOTEQvF2= MlvMOIg> NVXn[4pMTE2VTx?= MmPEdoV{[3WnczD0bIUh[3m2b4TvfIlkcXS7IH;mJFRVOSClZXzsd{BqdmS3Y3XkJIJ6KFOSRGSgbY4h[SClb37j[Y51emG2aX;uJIRmeGWwZHXueEBu[W6wZYK= M2nIV|I1OjB4MU[x
OS  NESzdFdCeG:ydH;zbZMhSXO|YYm= NF7FUFAzOM7:TR?= M1La[FRp NV;QPZk3cW6qaXLpeJMhfGinIHPlcIwh\GWjdHigZ4F2e2WmIHL5JHBFXA>? NF62NnozPDJyNEmzOy=>
RPE NIe0R2VCeG:ydH;zbZMhSXO|YYm= MoHZNVAx|ryP NVXOUHExPDiq MUDwZZJ1cWGubImgbY5pcWKrdIOgeIhmKGOjbIDhbY4uOSCjbnSgMVIh[WO2aY\heIlwdiCjczD3[YxtKGG|IITo[UBk[XOyYYPlJIFkfGm4YYTpc44> MVuyOFIxOjB3Mh?=
UD29a MmL6RZBweHSxc3nzJGF{e2G7 M1vEVlUx|ryP NGrSXGEzPGh? MkHBbY5pcWKrdIOgeIhmKGOnbHyg[IVifGhiY3H1d4VlKGK7IF7VWFM> Mni4NlQyQTB3N{S=
SH-SY5Y  NWC1[3B1SXCxcITvd4l{KEG|c3H5 NFnEUYsyOM7:TR?= M4DqflI1cA>? NHrYdVhifHSnboXheIV{KGOjc4Dhd4Uh[WO2aY\heIlwdiCjbnSgZ4VtdCCmZXH0bEBqdmS3Y3XkJIJ6KEiQRT2ySGc> MnuwNlQyPDV2NkO=
HeLa  MVXBdI9xfG:|aYOgRZN{[Xl? NUfhVJB3OTBxMkFOwG0> NEPM[WQzPGh? M{TOXYlvcGmkaYTzJJRp\SCjY4Tpeol1gSCxZjD0bIUhdWGsb4LpeJkhd2ZidHjlJI1mdWKncoOgc4YhfGinIHPhd5Bie2VvZnHtbYx6 MWeyOFE{PzJ4Nh?=
SCCVII  Ml\HRZBweHSxc3nzJGF{e2G7 NHfHWXYzPc7:TR?= MWSxbC=> M4LN[IlvcGmkaYTzJJRp\SClZXzsJItqdGyrbnegZYZ1\XJiZHHzZZRqdmmk NWr6U5ZWOjRzMk[0OlQ>
RAW 264.7 NF3sXmJCeG:ydH;zbZMhSXO|YYm= MYGyNO69VQ>? NXfCdGVTOTiq MWDpcoNz\WG|ZYOgUGM{NUmLL98yMYFkfGmwIILheIlwKGOxbYDhdoVlKHSxIFXDWHYuVU:VIITy[YF1dWWwdDDvcox6 MnywNlQyOTZ5MEe=
A549  NV7UdIVtSXCxcITvd4l{KEG|c3H5 NVraRmVZOi53zszN NH3CV4czPGh? M4fPXoRm[3KnYYPld{Bwemmmb37pck1qdmS3Y3XkJIF2fG:yaHHnfUBieyC5ZXzsJIFv\CCOb4PzJI9nKM7Wz5jtJIFte29ib3PjeZJz\WRiZIXybY5oKGG3dH;wbIFocWNicILvZ4V{ew>? MVWyOFExOjV{Mh?=
UM-SCC-10A  M1\M[WFxd3C2b4Ppd{BCe3OjeR?= NFXqPYQ2OML3TR?= M{LxVFJp NF;qRppz\WS3Y3XzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KGirZ3it[I9{\SCrc3;hcIFvfG:uYXP0c45m NHHsd4wzPDB7OEe1Ny=>
BGC-823 MVLBdI9xfG:|aYOgRZN{[Xl? NXi0U4JDOTBizszN Mn\WNlRp MUny[YR2[2W|IITleJJidmS{aX7lMYlv\HWlZXSgZZBweHSxc3nzxsA> NHS3e5IzPDB7OEWxNS=>
Nalm-6  NX3TS4tSSXCxcITvd4l{KEG|c3H5 NGTyWokzOM7:TR?= NY\pXINrPGh? MkfRbY5pcWKrdIOgZ4F{eGG|ZT24JIFv\CClYYPwZZNmNTNiYXP0bZZifGmxbjDhcoQhWEGUUD2xJINt\WG4YXfl M4P2OlI1ODN7OU[3
KHOS  M2HERWFxd3C2b4Ppd{BCe3OjeR?= NIm1eXA1OM7:TR?= MVOyOIg> NYXpO4Ni[myxY3vzJJRp\SCrbnPy[YF{\WRiY3zlZZZi\2Vib3[gZ4F{eGG|ZT2zJIFv\CCSQWLQJIlv\HWlZXSgZpkhSkKPRERCpC=> M4W4VFI1ODJ3M{[x
G292 M3jNbGFxd3C2b4Ppd{BCe3OjeR?= MmfFOFDPxE1? NVnQOIRtOjSq MXTicI9kc3NidHjlJIlv[3KnYYPl[EBkdGWjdnHn[UBw\iClYYPwZZNmNTNiYX7kJHBCWlBiaX7keYNm\CCkeTDCRm1FO8Li MlG2NlQxOjV|NkG=
MG-63 NXLKdI5wSXCxcITvd4l{KEG|c3H5 M1HZTlQx|ryP MXyyOIg> NWDx[WlY[myxY3vzJJRp\SCrbnPy[YF{\WRiY3zlZZZi\2Vib3[gZ4F{eGG|ZT2zJIFv\CCSQWLQJIlv\HWlZXSgZpkhSkKPRERCpC=> NY\lUZM5OjRyMkWzOlE>
EBV-transformed B cells NGTPeZpCeG:ydH;zbZMhSXO|YYm= M17qeVIx|ryP NHS1SVEzcA>? MYXEUXNQ NX\ZUHJ7[myxY3vzJIFvfGlvQ1S4NEBidmRiYX70bU1ETDh4IHHueIljd2S7LXnu[JVk\WRiYYDvdJRwe2m| NHXSe4QzPDByOE[yPC=>
IM-9 B MWXBdI9xfG:|aYOgRZN{[Xl? NU\qUmx6OjEQvF2= MUeybC=> NFi2V4FFVVOR M1XUZoJtd2OtczDhcpRqNUOGOECgZY5lKGGwdHmtR2Q5PiCjboTpZo9lgS2rbnT1Z4VlKGGyb4D0c5Nqew>? MmCxNlQxODh4Mki=
CNE1 MmP1RZBweHSxc3nzJGF{e2G7 M37wUVIx|ryP MoPLOFhp NEG2UYZjdG:la4OgUGsuSS2rbnT1Z4VlKGGyb4D0c5Nqew>? NGizbo4zOzl6NUCyPS=>
CNE2 M4HTV2Fxd3C2b4Ppd{BCe3OjeR?= MUOyNO69VQ>? MXu0PIg> NVnkUXFu[myxY3vzJGxMNUFvaX7keYNm\CCjcH;weI9{cXN? M1rsfFI{QTh3MEK5
HL-60 NFrYSXFCeG:ydH;zbZMhSXO|YYm= MlXTOVDDvU1? NI\ibmEycA>? NYDWd2N5TE2VTx?= MUfpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBDSTF2NR?= MUmyN|k1QDd3MR?=
L929 MkjkRZBweHSxc3nzJGF{e2G7 NFjPbHQyNjJ34pETOeKh|ryPwrC= NHHLZo0zPGh? NXi0T4N7[XWpbXXueJMhXE6IzsGtbY5lfWOnZDDu[YNzd3C2b4Ppd{BidmRiYYX0c5Bp[We7 MXqyN|k1OTd4OR?=
Jurkat MULD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MXWy{txO NHXMNIw1cA>? NVzDZ5JzemW4ZYLz[ZMh\3Kxd4ToJIlvcGmkaYTpc44h[W6mIN8yMYNifGWwaX6g[IVkemWjc3WgZpkhUFNvQWPB MoDLNlM5QTZyNkG=
RAW264.7  M13Nc2Fxd3C2b4Ppd{BCe3OjeR?= MVixNEDPxE1? MmfkNlRp MUTk[YNz\WG|ZYOgeIhmKGGyb4D0c5NqeyCrbnT1Z4VlKGK7IFfB M17WO|I{QDJyMkCz
A431  MlOyT4lv[XOnIFHzd4F6 NXjwfVJUPDEQvF2= MmDzNog> M2XjeoJtd2OtczDmbZNmfGmwLXnu[JVk\WRiY3zlZZZi\2Vib3[gZ4F{eGG|ZYOgZY5lKFCDUmC= NVvWeo9UOjN6MECwOVg>
Jurkat MmjCR4VtdCCYaXHibYxqfHliQYPzZZk> NHKwR4QzPS1zMEFOwG0> MVW2bC=> NYrWW3NocW6qaXLpeJMhgi2IQT3DUWsucW6mdXPl[EBk\WyuIHTlZZRp MYKyN|k{OzV|Mh?=
COS-7  NHfN[|FHfW6ldHnvckBCe3OjeR?= NVXy[4dRPTEEtV2= NYiy[JJWOjSq MV3h[oZm[3S|IITo[UBxem:lZYPzbY5oKG:oIFHUUlF{KHerdHigdI9tgVFidILhZ5R{ M3PEOVI{QTN|MkC4
CAL27 MUjBdI9xfG:|aYOgRZN{[Xl? MYGxNEDPxE1? M3rRS|Jp MWrzeZBxemW|c3XzJGN2ei2QUIOtdoVlfWOnZDD2bYFjcWyrdImgZpkhfXBidH:gPVAm MVWyN|kyPzN7Nh?=
THP-1  NV:yc3dQSXCxcITvd4l{KEG|c3H5 NGDOW48yOC13MN88US=> M2ThR|Jp MnnFbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkhfHKrcITvcIll\Q>? MYiyN|kxODJ7OR?=
K562 NFXhWJFCeG:ydH;zbZMhSXO|YYm= M{j5WlIx|ryP NEfNcWc1QGh? M1zVd4lvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KDRvTWW= MXOyN|g4Pjh{Nh?=
HL-60 M1HidWFxd3C2b4Ppd{BCe3OjeR?= MXexNFDPxE1? MmnqNlRp NV3YblJEcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliYXLp[ZRidmViZHn0[ZJx\W6nc9Mg NGTYb4UzOzh4NUe3PC=>
HeLa  MVnBdI9xfG:|aYOgRZN{[Xl? NYXjeHE5OjEQvF2= NUC2ZXBFOmh? Mo\kbY5pcWKrdIOgSG1OWCCrbnT1Z4VlKGGyb4D0c5Nqew>? NYm4bINxOjN6NkO5OlY>
U251 M37qN2Fxd3C2b4Ppd{BCe3OjeR?= MYiyNO69VQ>? M3Hh[|I1cA>? Mo\XbY5pcWKrdIOgZ4F{fGmlaX6gbY5lfWOnZDDHNk9OKHCqYYPlJIFzemW|dDDhcoQh[XCxcITvd4l{ M1LZdVI{QDF4OEG2
HL-60 MVLBdI9xfG:|aYOgRZN{[Xl? MYe1NOK2VQ>? M1X0W|Rp MlflZoxw[2u|IITo[UBkdGWjdnHn[UBw\iClYYPwZZNmNTNuID25MEBidmRiUFHSVEBqdmS3Y3XkJIJ6KD[| MUmyN|gxPDdyNh?=
Ec-109 NGm0ZoFCeG:ydH;zbZMhSXO|YYm= M4rUelExKM7:TR?= MlL1OFhp NWjQVppEemWycnXzd4V{KFCHLX3l[IlifGWmIFXjMVExQSClZXzsJIFxd3C2b4Ppdy=> MmPDNlM4QDJ4NEG=
RKO NGnETZVE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NEm2dmIyOCEQvF2= NX62VWt1OjSq M33YfolvcGmkaYTzJJRp\SCmZXPy[YF{\SCxZjDj[YxtKH[rYXLpcIl1gSClYYXz[YQh[nliRFHC NFzmOlAzOzd3OEC2OC=>
T98G MoXHR4VtdCCYaXHibYxqfHliQYPzZZk> MUSxMVExOM7:TR?= MnPpNlRp MXfpcZBzd3[nczDj[YxtKH[rYXLpcIl1gSClb4Ty[YF1dWWwdDD3bZRpKFSV M{m4fFI{PzZ7Mke1
Jurkat M1HUR2NmdGxiVnnhZoltcXS7IFHzd4F6 NGPaUo8yODBvMkCw{txO MmS0NlRp MXrpcohq[mm2czDIZWE1KGmwZIXj[ZMh[XCxcITvd4l{KGSncHXu[IVvfCCxZjDjc45k\W62cnH0bY9vyqB? M3XUelI{PzN{NEix
Molt-3  Ml2yRZBweHSxc3nzJGF{e2G7 NFHj[FA2OM7:TR?= M{LCW|Jp NYPyO2lqemWmdXPld{Bu\WyjdH;ubY4ucW6mdXPl[EBieG:ydH;zbZM> M12xfVI{PzJ3MEGz
hMSC12 MoTERZBweHSxc3nzJGF{e2G7 MXGxNFDPxE1? NHHaUFI1\A>? MVXpcohq[mm2czDvd5Rmd2enbnnjJIN2dHS3cnWtbY5lfWOnZDDj[YxtKGSnYYToJIFv\CClYXzjbYZq[2G2aX;u M2LoXlI{PjV5OEKy
HM7  Mne4RZBweHSxc3nzJGF{e2G7 MUiyNO69VcLi MmTENYg> MUHicI9kc3NiYYDpZ5Vt[XKnbjDBJIFk\XSjdHWtbY5lfWOnZDDjZZNx[XOnLUOgZYN1cX[jdHnvckBidmRiUFHSVEBkdGWjdnHn[S=> MW[yN|U5OzRzMh?=
Hep-2  MX3BdI9xfG:|aYOgRZN{[Xl? M{LsTFIx|ryPwrC= M2\WW|I1cA>? MULEUXNQ MkCxZYxt\X[rYYTld{B1cGViZHXjdoVie2Vib3[gZ4VtdCC4aXHibYxqfHliaX7keYNm\CCkeTDzbYxq[mmwaX6= M3\acVI{PThyMEOy
HSCs MVHBdI9xfG:|aYOgRZN{[Xl? M{XLW|Ux|ryP MYGyOIg> NX;VXHhxTE2VTx?= NHXIOVNqdmirYnn0d{BvcWyxdHnubYIucW6mdXPl[EBFVkFiZHHtZYdmKGmwZHnjZZRm\CCkeTDQRXJRKGOuZXH2ZYdm NFW4SoUzOzR7OUi3OC=>
HL-60  MX\DfZRwfG:6aXPpeJkhSXO|YYm= MVOyNO69VcLi MVmyOIg> NYe4V4JnemWmdXPld{B1cGViY4n0c5RwgGmlIHXm[oVkfCCxZjDFdpk2 NF7W[JUzOzR7NES4NC=>
HA M3nubGFxd3C2b4Ppd{BCe3OjeR?= NFSxdoI2OM7:TR?= MUeyOIg> NXvwfG9Fe3WycILld5NmeyC2aHWgZ4xm[X[jZ3Wgc4YhWEGUUDDhcoQh[2G|cHHz[U0{NCBvNzygZY5lKC17IHnu[JVk\WRiYomgZo9zfGW8b33pZk9USUiD M3TSblI{PDd3OUW2
C666-1 M3XrZWFxd3C2b4Ppd{BCe3OjeR?= MYK1NO69VQ>? M3T6bVI1cA>? MU\zeZBxemW|c3XzJJRp\SClbHXheoFo\SCxZjDQRXJRKGGwZDDjZZNx[XOnLUOsJE04NCCjbnSgMVkhcW6mdXPl[EBjgSCkb4L0[ZpwdWmkL2PBTGE> NXflS5ZNOjN2N{W5OVY>
Hepa1-6 MXvBdI9xfG:|aYOgRZN{[Xl? NGnaXlU2OM7:TR?= MUiybC=> NEXmUJZqdmirYnn0d{BkfXKldX3pckBidmRicnXzeoVz[XS{b3ytbY5lfWOnZDDhdI9xfG:|aYO= MXGyN|Q1Pjd3Mx?=
PLC/PRF/5c MXLBdI9xfG:|aYOgRZN{[Xl? NFTpZmM2OM7:TR?= MYCxbC=> NGOyVoZxemW4ZX70d{BieG:ydH;zbZMhfHKrZ3fldoVlKGK7IFPJUi=> M322TFI{PDN6OEK0
HCT116 NI\mcFBCeG:ydH;zbZMhSXO|YYm= MWmxNFDPxE1? MojsNU42cA>? MV;pcohq[mm2czDPd{1qdmS3Y3XkJINmdGxiZHXheIg> M4\DcFI{PzR2M{Wz
HCEC NWOwXYJlTnWwY4Tpc44hSXO|YYm= MnTUOVDPxE1? NG\SbHY4Omh? Moi5SG1UVw>? NG\hdFJz\XO2b4Lld{Bw\iC2aHWgco9zdWGuIFjDSWMheGinbn;0fZBm M{HLfVI{PzR{MEGx
Primary rat cerebral cortical neurons MVfBdI9xfG:|aYOgRZN{[Xl? NYHJbI9JOTByzszN Mn7ZNYg> NV\wdXJjeHKndnXueJMhS2RvaX7keYNm\CCjcH;weI9{cXNiYX7kJINmdGxiZHXheIg> MViyN|c1OTNzNx?=
MDA-MB-231  MVLBdI9xfG:|aYOgRZN{[Xl? MmDsNlXPxE1? NULpU49mOjSq MljyZYJzd2ejdHXzJIN6fG:2b4jpZ4l1gSCjbnSgZ4xm[X[jZ3Wgc4Yh[2G|cHHz[U0{KGGwZDDQRXJRKGmwZIXj[YQh[nliUnez MlvsNlU{Ozd3NES=
NLRP3-Tet-on-MC/9  MnW5RZBweHSxc3nzJGF{e2G7 M2\1cVExNTRyzszN NFXRNmUyOmh? MYrheJRmdnWjdHXzJJRp\SClZXzsJIRm[XSqIHPheZNm\CCkeTDDRXBUNWG|c3;jbYF1\WRiTlzSVFMhdXW2YX70d{BqdiC2aHWgWIV1NW:wIIP5d5RmdQ>? MmHWNlM4ODN|OEm=
KNS42  MWLBdI9xfG:|aYOgRZN{[Xl? M4HmRVUx|ryP MkLVNYg> NWLuSoFHemWmdXPld{Bk\WyuIHTlZZRpKGGwZDDjc41xdGW2ZXz5JIFjd2yrc3jl[EBk[XOyYYPlJFMwPyCjY4Tpeol1gSCrbjDy[ZNxd26|ZTD0c{BCSlRvMk[zM|JFTy:vZYTmc5JucW5iY3;tZolv[XSrb36= NFzYWZAzOzZ7MUG0OS=>
MCF-7  MkjkRZBweHSxc3nzJGF{e2G7 MkL0NlDPxE4EoB?= NILOS444Omh? NIPmWYVqdmirYnn0d{BmeXWxbD2gZY5lKDRvT1jUMY1m\GmjdHXkJIFxd3C2b4Ppdy=> MWOyN|Y4PTZ2Mx?=
hCMEC/D3  NWPrVVFtSXCxcITvd4l{KEG|c3H5 NYmxOnZiOjYQvF2= NH3J[G84Omh? NX;4UXBHemWmdXPld{BNfHiDIHnu[JVk\WRiYYDvdJRwe2m| M{DWUFI{PjZ3MUm4
Jurkat NVHQSXNlSXCxcITvd4l{KEG|c3H5 MVqxNk42NTVyzszN M3LWPVFp M{P1WoRwe2ViZHXw[Y5l\W62bImgd5VxeHKnc4Pld{BUWEhvaX7keYNm\CCSYYKtOEBkdGWjdnHn[UwhWEGUUDDjcIVifmGpZTygSG5CKG[{YXft[Y51[XSrb36sJIFv\CCub4PzJI9nKH[rYXLpcIl1gQ>? NUHnNml2OjN2NEK5O|Y>
CNE-1 Mny3RZBweHSxc3nzJGF{e2G7 MWGyNO69VcLi MnzoNlRp MmXwbY5pcWKrdIOgVmFFODBzLXnu[JVk\WRiY3XscEBl\WG2aB?= MViyN|QzPjh3MB?=
HONE-1 MkfGRZBweHSxc3nzJGF{e2G7 MXSyNO69VcLi NXfBSZA6OjSq MXnpcohq[mm2czDSRWQxODFvaX7keYNm\CClZXzsJIRm[XSq NYX4ZZVTOjN2Mk[4OVA>
astrocytes cell NUPZWZQ{SXCxcITvd4l{KEG|c3H5 M1LyVVQx|ryP MVG2bC=> NE\sWpdz\WS3Y3XzJIViemy7IHHwc5B1d3OrczDpcoR2[2WmIHL5JJN1[XW{b4Pwc5JqdmV? M{XWSlI{PDFzN{e4
U-937 M4f5V2Fxd3C2b4Ppd{BCe3OjeR?= M{\XZlEx|ryP NHPVc2w{OG2rbh?= NInhTG1xemW4ZX70d{BVVkZvaX7keYNm\CCwZXPyc5B1d3Orcx?= NELxTlAzOzRzMEe0PC=>
MDA-MB-231 M3TjO2Fxd3C2b4Ppd{BCe3OjeR?= MXSxNFDPxE1? NX2yWIpQOWh? NFjIcVBqdmirYnn0d{B{\W6|aYTpfoF1cW:wIITvJHRTSUmOIIXwc44hVVSGSDDkc5dvNXKnZ4XsZZRqd25? NXex[pl7OjN2MEi0Nlk>
HeLa  NUXW[YlGSXCxcITvd4l{KEG|c3H5 M4H1cVExOM7:TR?= MnrWNog> M3TLfIJtd2OtczDKVnMuOTViSX7keYNmeyCDcH;weI91cWNiQ3XscEBF\WG2aB?= M{e3PFI{OzR2MES1
Ec109 NFr6RW1CeG:ydH;zbZMhSXO|YYm= MVWxNO69VQ>? NEDITo03cA>? MnSzZoxw[2u|IHHwc5B1d3SrYzDjc41jcW6jdHnvckBw\iCWYYStV41i[055IHHu[EBz[WSrYYTpc44> MmLMNlM{Ozh3Nki=
H460  M3\SW2Fxd3C2b4Ppd{BCe3OjeR?= NVK0S5F1OTEQvF2= MlWwOog> NEC0PI1jdG:la4OgZZBweHSxdHnjJINwdWKrbnH0bY9vKG:oIGTheE1UdWGlTkegZY5lKHKjZHnheIlwdg>? MYOyN|M{QDV4OB?=
HeLa  MYHBdI9xfG:|aYOgRZN{[Xl? MVO1NO69VQ>? MlPqNU42cA>? NHLGcZBi[nKxZ3H0[ZPDqEOqbHHtfYRq[S2rbnT1Z4VlKGGyb4D0c5Nqew>? MUKyN|MxOzhyNB?=
SK-HEP1 MUPBdI9xfG:|aYOgRZN{[Xl? NYroPXU6OTByzszN Mly0NYg> MV3pcohq[mm2czDDdnQyKGGldHn2ZZRm\CClYYPwZZNmNTNuID23MEAuQCxiLUmsJIFv\CCyb3z5LGFFWC2{aXLvd4UqKHCxbInt[ZJie2V? MmnNNlM{ODJ4NUC=
QGY7701 NHr0[WFCeG:ydH;zbZMhSXO|YYm= NUXKW3NvOjYQvF2= MXexMlVp MYfpcohq[mm2czDhZ4N2dXWuYYTpc44hd2Zic4XiMWcyKHCqYYPlJIlv\HWlZXSgZpkhTE:[IDugdZVmemOndHnu M3P6XVI{OjRyME[x
HepG2 NGn3VVRCeG:ydH;zbZMhSXO|YYm= NULQVJI1OjEQvF2= NY[wNXRsOzCvaX6= MYXpcohq[mm2czD0bIUh\W6qYX7j[YQh[2WubDDk[YF1cCCkeTDjc41jcW6nZDD0doVifG2nboSgc4Yh[XCrZ3XubY4h[W6mIGTSRWlN MVmyN|IzPDJ|OR?=
U87  NIG3XYhCeG:ydH;zbZMhSXO|YYm= NVjRZVViOjYQvF2= MYeybC=> M2PUWIRm[3KnYYPld{Bqe2:uaYH1bZJqfGmpZX7pckApUVOOKT3pcoR2[2WmIHHwc5B1d3SrYzDj[YxtKGSnYYToMEBjfXRibn;0JI5m[3KxdHnjJINmdGxiZHXheIg> M1j6OlI{OjJ7NkK2
HSC-2 MYPBdI9xfG:|aYOgRZN{[Xl? NEC0fGIzPS93MN88US=> NGTYUFgycA>? NHW5UllqdmirYnn0d{BUVi1|OD3pcoR2[2WmIHP5eI91d3irY3n0fS=> NEDMfmkzOzF3NUK0PC=>
HSC-4 NV;KNY9WSXCxcITvd4l{KEG|c3H5 NUDwTZd1OjVxNUFOwG0> NH3rNZEycA>? MX7pcohq[mm2czDTUk0{QC2rbnT1Z4VlKGO7dH;0c5hq[2m2eR?= MXWyN|E2PTJ2OB?=
CL-1 NVW3XJhuSXCxcITvd4l{KEG|c3H5 NVHRXHNPOjEQvF2= MYKxbC=> NEjMZmtjdG:la4OgU3A1PDliaX7keYNm\CClZXzsJIRm[XSq MoS3NlMyOzF5OEK=
MEL NEDnfmtCeG:ydH;zbZMhSXO|YYm= NH31S4czOM7:TR?= MXyyOIg> NYjUcWVxTE2VTx?= MUHpcZBicXKnczDQNng4NWmwZIXj[YQhVUWOIHPlcIwh[XCxcITvd4l{ NXTXU4g1OjNyMUS4PFc>
Bel-7402  NXHKRY17S2G|cHHz[UBC[3SrdnH0bY9vKEG|c3H5 MV:1NO69VQ>? MkG5Nog> MlHWbY5pcWKrdIOgVGNGNWmwZIXj[YQh[W6xaXvpdy=> NIfvUoozOzByOEe0Ni=>
Eca-109 M3nvZmFxd3C2b4Ppd{BCe3OjeR?= MViyOe69VQ>? M4\NOlMxdWmw MVfpcohq[mm2czDCTk1DOTFvaX7keYNm\CClZXzsJIRm[XSq NV7ncHZPOjNyN{[5Olc>
MEL M3zTS2Fxd3C2b4Ppd{BCe3OjeR?= MoLVNlDPxE1? MV6xbC=> MYnEUXNQ M1;OOolueGGrcnXzJHAzYDdvaX7keYNm\CCPRVygZ4VtdCCjcH;weI9{cXN? MX:yN|AyPDh6Nx?=
Bel-7402  NIWzTmtCeG:ydH;zbZMhSXO|YYm= NEnsV4w2OM7:TR?= NX3q[XdNOmh? M{T4NIlvcGmkaYTzJHBETS2rbnT1Z4VlKGGwb3nrbZM> NHy3TmwzOzByOEe0Ni=>
L929 NW[2do5KTnWwY4Tpc44hSXO|YYm= M2faUVIvPc7:TR?= NW\VbpFQOWh? MXzpcoNz\WG|ZYOgVmlROSCneIDy[ZN{cW:wIHHu[EBmgGGlZYLiZZRm\CCWTldOtU1qdmS3Y3XkJI1qfG:laH;u[JJq[WxiZInz[pVv[3Srb36gZY5lKFKRUzDwdo9lfWO2aX;u MViyN|AxODVzOB?=
RCC  MmHCR4VtdCCYaXHibYxqfHliQYPzZZk> MV[xNFDPxE1? NYWxdpZROjSq NHe3eXNz\WOxdnXy[ZMhfGinII\pZYJqdGm2eTDv[kBk\WyuczDlfJBwe2WmIITvJFE2\C2SR1qy Mn;2NlI6QTF2OUS=
NB2a/d1 NX;LZ2lzSXCxcITvd4l{KEG|c3H5 NXrM[G1ZOTByzszN NXTxfVd7PzKq NGP2dGpifHSnboXheIV{KHO2YYXyc5Nxd3KrbnWtbY5lfWOnZDDjZZNx[XOnIHHjeIl3cXS7LDDQRXJRNCCjbnSgeIF2KGOuZXH2ZYdm NVT2XG8yOjJ7OEi1OFE>
T cell NGD0dXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnB[2xlOjVvMUCw{txO NYqzO5RjOjSq NGjsToJld3OnLXTldIVv\GWwdHz5JIlvcGmkaYTl[EBVKGOnbHygdJJwdGmoZYLheIlwdiCvZXTpZZRm\CC2aILveYdpKHSqZTDjc{1{fGmvdXzheIlwdiC5aYToJIFvfGlvQ1SzJIFv\CCjboTpMWNFOjh? M3TKU|IzQTh{NUO4
K562 MmjiRZBweHSxc3nzJGF{e2G7 NFe4[24yODEQvF2= M2\NPFFp MmO4Zoxw[2u|IFHico9j[X[rc3P1ceKhTi2rbnT1Z4VlKGGyb4D0c5Nqew>? M4jEWVIzQTd{M{ey
Jurkat  NFr3VY5CeG:ydH;zbZMhSXO|YYm= NEHuW|Y1OM7:TR?= Mm\ENYg> NFjrVGpi[m:uaYPo[ZMhTmG|TD3pcoR2[2WmIHPhd5Bie2ViYXP0bZZifGmxbjDhcoQh[2WubDDk[YF1cA>? NHfQcYMzOjl2MkezPC=>
BGC-823 NInHflhCeG:ydH;zbZMhSXO|YYm= Mn;YNVAx|ryP NISxPFAycA>? MWrwZZJ1cWGubImgdoV{[3WnczDj[YxteyCjZ3HpcpN1KGSjbXHn[UBw\iCmYXnkfoVqdg>? MojGNlI6OjZ3NEW=
Hep3B MVXBdI9xfG:|aYOgRZN{[Xl? Mnf5OVDPxE1? MX6xbC=> MYXicI9kc3NiYYDvdJRwe2m|IHnu[JVk\WRiYomgTGVIS3N? Mn7uNlI6OjNzNUS=
LLC-PK1 NH3CfYlCeG:ydH;zbZMhSXO|YYm= NHnY[|gzOM7:TR?= NH;sW5gycA>? M{nhT5Bz\X[nboTzJINqe3CuYYTpck1qdmS3Y3XkJIRm\3KjZHH0bY9vKG:oIFH0[|UtKGKnY3zpck0yNCCjbnSgRZRoOTJicILveIVqdnN? NGHUXmIzOjh7NkCzOy=>
A549 NUXKRWp7SXCxcITvd4l{KEG|c3H5 NX7NSVR3PTEQvF2= NHflfpYycA>? NH;1fm1jdG:la4OgeIhmKEKDST3pcoR2[2WmIHHwc5B1d3Orc9Mg M1P4VFIzQDh5MkG1
SGC-7901  NUL3UlQ{SXCxcITvd4l{KEG|c3H5 NF35Xo4yOM7:TR?= Mn;mNlRp MY\pcohq[mm2czFOtkzPui2maX3leIh6dGGlconsd4hqc2:waX6tbY5lfWOnZDDhdI9xfG:|aYRCpC=> M1HEUVIzQDR6NUm3
DM6 M2PTNWFxd3C2b4Ppd{BCe3OjeR?= M{nTNVExOM7:TR?= M4LXWFczcA>? MnX4Zoxw[2u|IHLveIghTTKILUGgZY5lKEV{RoTyMY1m\GmjdHXkJIN6fG:2b4jpZ4l1gQ>? NWjFXmlWOjJ6MkWzNlg>
MCF-7, MDA-MB-468, Caco-2 NFy2OFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTKeY16PTEQvF2= MVS0PIg> M3fabolvcGmkaYTzJJRp\SClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIlv\HWlZXSgZpkhe2Gyb37pci=> Mnr4NlI5ODB7Nki=
A2750  MlLwRZBweHSxc3nzJGF{e2G7 NH7UVnIzOM7:TR?= Mk\jNog> MWLEUXNQ MnfjZoxw[2u|IHPhd5Bie2ViY3zlZZZi\2ViZIXybY5oKGinbHXuZYxqdiC2cnXheI1mdnRiYX7kJJJm\HWlZYOgZZV1d3CqYXfpZ{Bk\WyuIHTlZZRp M4\FSlIzPzh2M{[z
U87  MUnBdI9xfG:|aYOgRZN{[Xl? MlHKNlDPxE1? NXLVZ3hCOjSq M4nFbZJm\HWlZYOgeIhmKGGyb4D0c5NqeyC{YYTlJIlv\HWlZXSgZpkhWEyDQh?= NF;2UmszOjd5OEe4NC=>
HT1080 NVO3XHdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrFT2k3PTEQvF2= M2L1PVdl NGTXclRqdmirYnn0d{B1cGViY3XscEBoem:5dHigbY5pcWKrdHnvckBk[XW|ZXSgZpkh[2:vYnnu[YQhfHKnYYTt[Y51KG:oIFTDRUBidmRiT13Q MXKyNlc1ODl6NB?=
A549  NV;5VXlCSXCxcITvd4l{KEG|c3H5 NVvCTHRSPTEQvF2= M4DofVJp MVHwZZJ1cWGubImg[IVkemWjc3XzJJNw\Gm3bTDz[Yxmdmm2ZT3pcoR2[2WmIHHwc5B1d3Orcx?= M1XnbFIzPzJzOEC0
Primary OPC Moi3RZBweHSxc3nzJGF{e2G7 MlPmNe69VQ>? MUm2bE8zPGh? MWDy[YR2[2W|IITo[UBx\XKlZX70ZYdmKG:oIHPlcIx{KGmwIHXhdox6NSCjbnSgcIF1\S2jcH;weI9{cXNxbnXjdo9{cXN? NF\wem0zOjdyN{O4OS=>
PMNs MnHyRZBweHSxc3nzJGF{e2G7 NUjwbVVmPDEQvF2= NF;KO4I3cA>? M37nS2ROW09? NVLNVIVpemW4ZYLz[YQhfGinIHHtc5VvfCCxZjDjcIVifmWmIHPhd5Bie2VvMzD0c{Bv\WG{II\lbIlkdGVibHX2[Yx{ NI\EbJIzOjZ7MkW3Oy=>
A549  NFvHVm1CeG:ydH;zbZMhSXO|YYm= NWm4fGVCPTEQvF2= M3fQWlFp MXjwdoV3\W62czDhdI9xfG:|aYOgbY5lfWOnZDDifUBD[W:qdX;zbYRmKEl? M3nLdVIzPjh5NkO1
AGS NWjLTXFLSXCxcITvd4l{KEG|c3H5 MXmyNO69VQ>? MUCxNog> NIXzTlNqdmirYnn0d{B1cGViYXP0bZZifGmxbjDv[kBxem9vY3HzdIF{\S1|IHnuJJJme3CxboPlJJRwKHSqZTDFeG9C[yCocnHjeIlwdg>? MUmyNlY5PzN7OB?=
shC9  MWfBdI9xfG:|aYOgRZN{[Xl? NX7zfIw3OTEQvF2= NVjNc3BEOT[q Mn3kZox2dnS|IGPITEBmgHC{ZYPzbY9vKGmwIIPoR|kh[2WubIOg[Zhxd3OnZDD0c{BmcXSqZYKgVGEhd3JiTGDD MnP2NlI3PDFyOUS=
primary MEFs NVnoVGJnTnWwY4Tpc44hSXO|YYm= MUCxNog> MWpCpIlv[3KnYYPld{BmfG:yb4Pp[IUucW6mdXPl[EBucXSxY3jvcoRzcWGuIH3lcYJz[W6nIHTldI9t[XKrenH0bY9v M2PNb|IzPjF|N{[3
3T9 MEFs MX3GeY5kfGmxbjDBd5NigQ>? MmjmNVZp NUmxO5c2cW6lcnXhd4V{KGO7dH;jbJJwdWViYzDy[Yxm[XOnIHHmeIVzKGW2b4Dvd4ll\S22cnXheI1mdnR? Mn7VNlI3OTN5Nke=
3T9 MEFs MlS5SpVv[3Srb36gRZN{[Xl? NVnnOVBVOTiq MmLOeZBz\We3bHH0[ZMhcW6rdHnheI9zKGOjc4Dhd4UuQSCkdYSg[I94dnKnZ4XsZZRmeyCnZn\lZ5RweiClYYPwZZNmeyCjZoTldkBmfG:yb4Pp[IUhfHKnYYTt[Y51 MkDENlI3OTN5Nke=
MDA-MB-231  M4nPNGFxd3C2b4Ppd{BCe3OjeR?= NFHTZXYzOM7:TR?= MV:0[C=> NIPlUpNz\WS3Y3XzJJRp\SClZXzsJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KG2ndH\vdo1qdiC2cnXheI1mdnRid3HzJJNq\26rZnnjZY51dHl? MV:yNlU6OzR2MR?=
C6  MX3BdI9xfG:|aYOgRZN{[Xl? NX\HU|ZDOTEQvF2= M2jpTlI1cA>? MYnicI9kc3NidHjlJJN2eHC{ZYPzbZZmKGWoZnXjeEBw\iC2aHWgdIVxfGmmZTDvckB3cWGkaXzpeJk> M{f3NFIzPTh6OUiw
HL-60  NWfyOop2SXCxcITvd4l{KEG|c3H5 NVuwZ4I5OTByzszN NGjTcYozPGh? MVnpcohq[mm2czD0bIUh[2WubDDhdI9xfG:|aYOgd4Vt\WO2ZXSgLEsqNW2nboTofYwh|rJvKEJiirI3MS2maXfseYNweHm{YX7vd4ll\cLiNR?= M1GxelIzPTR4Nk[5
HL-60 MXzBdI9xfG:|aYOgRZN{[Xl? M17kWlExNThyzszN MVW0bC=> NV\jNmtocW6qaXLpeJMhXEeKUT3pcoR2[2WmIHPlcIwh[XCxcITvd4l{yqB? MWWyNlUzOzJ{OR?=
BCC NX7KfFJOSXCxcITvd4l{KEG|c3H5 MlTpOVDPxE1? M2njOFFp MmDpbY5pcWKrdIOgSGFVWy2vZXTpZZRm\CCpcn;3eIghcW6qaXLpeIlwdg>? MmDrNlI2OTl2M{[=
RAW 264.7 MWLBdI9xfG:|aYOgRZN{[Xl? NV2ySWdJPTBxMUCw{txO MlzSNYg> M4XyN4NwdmOnboTyZZRqd25vZHXw[Y5l\W62IHnubIljcXS|IFTPUk1qdmS3Y3XkJJJTVkFiY3zlZZZi\2V? NWW5V5lNOjJ2OUG0NlY>
K562 M4Xme2Fxd3C2b4Ppd{BCe3OjeR?= NWHuNHNbOjYQvF2= NV7nXlVzOmh? MnzUdJJmfmWwdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkh[29vdILlZZRu\W62IIfpeIgh[W23cnXud4lvKEdiYX7kJHRTSUmO NEX1RokzOjR6M{e3Oy=>
SGC-7901 MV\BdI9xfG:|aYOgRZN{[Xl? NUfhUXlMOjBizszNxsA> M3zkSlJp NGTpWpNifHSnboXheIV{KEh{T{NCpI9zKFSQRjFOtU1qdmS3Y3XkJINmdGxiYYDvdJRwe2m|IHHzJJdmdGxiYYOgZ4F{eGG|ZT2zJIFkfGm4aYT5xsA> MV:yNlQ4OTV6OR?=
PC3 NHjLXXVCeG:ydH;zbZMhSXO|YYm= Ml;KNVDPxE1? MUi0bC=> NUDUZWlx[2:3boTldpMh\myjdn;jc5hq\C2rbnT1Z4VlKGOjc4Dhd4UuemWuYYTl[EBieG:ydH;zbZM> M1i2TFIzPDdzOUe0
SMMC-7721 NGfZOFhCeG:ydH;zbZMhSXO|YYm= NGnpZ|E2OM7:TR?= MUC0PIg> MUXheJRmdnWjdHXzJI9VWi2rbnT1Z4VlKGGyb4D0c5Nqew>? Mn7QNlI1PjV6M{O=
HeLa  MX\BdI9xfG:|aYOgRZN{[Xl? Ml7rOVDDqM7:TR?= MoLMOE85cA>? NVf2fmZYcW6qaXLpeJMhW1SVLXnu[JVk\WRibHH0[U1xcGG|ZTDhdI9xfG:2aXOg[ZZmdnS| MVSyNlQ3ODVyNB?=
HeLa  NG\CWVlCeG:ydH;zbZMhSXO|YYm= M17GTFUxyqEQvF2= NVLwR4k3OWh? MWXzeZBxemW|c3XzJJRp\SCIUlHQMYlv\HWlZXSgZYNkfW23bHH0bY9vKG:oIHHucoV5cW5iVjDwc5NqfGm4ZTDj[Yxtew>? MUiyNlQ1QTR2MB?=
T47D  M{DDT2Fxd3C2b4Ppd{BCe3OjeR?= NVGzT2w5OTByzszN MYCxbC=> NUm4XnBT[myxY3vzJJRp\SCpZX7ldoF1cW:wIH;mJGUu[2GmL1PUSlIh[nliU2TT M3jGfVIzPDBzMU[4
HeLa  MYPBdI9xfG:|aYOgRZN{[Xl? NIXTRng{OM7:TR?= MWq0bC=> NVnPdnJZyqCrbnPy[YF{\XNidHjlJIdmdmW{YXygZ4VtdCC4aXHibYxqfHliNEigbEBi\nSncjDwbI91d2S7bnHtbYMhfHKnYYTt[Y51yqB? NG\2bW4zOjN7NEK0PC=>
HCC MUfBdI9xfG:|aYOgRZN{[Xl? NXXEW2dQOjBizszNxsA> M{n5XVJp MlfGZZR1\W63YYTld{B1cGViRFjBJIlv\HWlZXSgZYN1cX[jdHnvckBw\iCSQWLQ MnL6NlI{PDJ5M{K=
mESCs NEHITWVCeG:ydH;zbZMhSXO|YYm= M1LTWFIvPc7:TR?= M{TM[VJp MnP5bY5pcWKrdIOgeIhmKE6jRj3t[YRq[XSnZDDjZZNx[XOnIHHjeIl3[XSrb36= M1W2bFIzOjh3Mke0
EMT-6  MYrDfZRwfG:6aXPpeJkhSXO|YYm= M2PIOlExOM7:TR?= M{S5e|Fp NUHRe25oeGG{dHnhcIx6KGKub3Pr[YQh[2WubDDk[YF1cCCrbnT1Z4VlKGK7IIPpdoFu\XOrbnW= NX;Zb|VWOjJ{NUG5NlE>
MCF7 NEDjNHFCeG:ydH;zbZMhSXO|YYm= M4XwO|UxyqEQvF2= NVHs[XlJOWh? NX7GWGRRcW6qaXLpeJMhWEFiYXP0bZZifGWmIHPhd5Bie2VvMzygMVktKGGwZDDwc4x6MEGGUD3ybYJwe2VrIIDvcJlu\XKjc3W= MmXYNlIzOjN|NEW=
K562 NWrFRYRCSXCxcITvd4l{KEG|c3H5 NV7SSJlzOjBizszNxsA> NUflOIh{PDiq M1zmb2ROW09? MY\icI9kc3NibHHwZZRqdmmkLXnu[JVk\WRiaX7obYJqfGmxbjDv[kB3cWGkaXzpeJkh[W6mIHHwc5B1d3OrczDpcoR2[3Srb36= MYeyNlIyPjF3OB?=
Molt4-hyg M4q1[GFxd3C2b4Ppd{BCe3OjeR?= MWmxNO69VQ>? NYWycYtlOC53aB?= MlT5Zoxw[2u|IH\hdo5me2:uLXnu[JVk\WRiY3HzdIF{\S1|LXzpb4Uh[WO2aY\peJk> MVWyOlI4PThzMR?=
HeLa M{n6T2Fxd3C2b4Ppd{BCe3OjeR?= NUPseIxzOTEQvF2= NInlWFQxNjWq NWH0VFRzcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nlidHjlJINwdWKrbnXkJJRz\WG2bXXueEB4cXSqIHfvcYl{cW5iTjDhcoQhXFKDSVy= M365PFIzOTd7Nk[x
Jurkat T M4n3eGFxd3C2b4Ppd{BCe3OjeR?= MW[zNO69VQ>? MWqwMlVp NEfUfoxFVVOR NIDtbYpjdG:la4OgeIhmKHqrcnHtMYlv\HWlZXSgZZBweHSxc3nz MnvZNlIyPTl6OUi=
Neutrophil MWPBdI9xfG:|aYOgRZN{[Xl? M{fKSFIx|ryP MVOwMlVp NGixdFFifHSnboXheIV{KHSqZTDwdo8u[XCxcITveIlkKGWoZnXjeEBw\iCPYWKx M3;xUVI3OTl4OES0
HCT116 Mnn4RZBweHSxc3nzJGF{e2G7 M1nEclUxyqEQvF2= NELoc4kzcA>? NH7VRllz\X[ncoPld{B{gW6ncnfpd5Rq[yCjcH;weI9{cXNiZX\m[YN1eyCxZjDj[Yxm[2:6aXKgZY5lKE6SQz2xOuKh NHXNcGozOjF3OUe1Ni=>
MDA-MB-231  NUjPXpduSXCxcITvd4l{KEG|c3H5 NWfxOoxbOi53LUeuOe69VQ>? NF;G[mIzcA>? NYfybIVrcW6qaXLpeJMhfGinIHPlcIwh\GWjdHigc4YhVUSDLV3CMVI{OSClZXzsd{BqdmS3Y3XkJIJ6KFOGVDDpckBiKGOxbnPlcpRz[XSrb36g[IVx\W6mZX70JI1idm6nch?= NGL4SVkzOjFzNUWyOi=>
LNCaP NVy2c2NiSXCxcITvd4l{KEG|c3H5 MkfHOFDPxE1? MnTPNog> Ml7ubY5pcWKrdIOgZpV1\WmwIHnu[JVk\WRiY3XscEBieG:ydH;zbZM> NW[xfGg2OjJzMUS3OlQ>
MB231 M3XOO2Fxd3C2b4Ppd{BCe3OjeR?= Ml[5NVAx|ryP MkL3NYg> MknUSG1UVw>? M2SyZoFjem:pYYTld{B1cGViaX7keYN1cW:wIH;mJINmdGxiZHXheIgh[nliV1XFNUBqdmirYnn0bY9vNCCWUlHJUEB1emWjdH3lcpQtKGGwZDD0bIUh[2:vYnnuZZRqd25? NYLBOVlxOjJzMUK5OFA>
HCC38  NUDINZpKSXCxcITvd4l{KEG|c3H5 MUSxNFDPxE1? M1v0eVFp NWPp[m1uTE2VTx?= NXLVbFF3[WK{b3fheIV{KHSqZTDpcoR2[3Srb36gc4Yh[2WubDDk[YF1cCCkeTDXSWUyKGmwaHnibZRqd25uIGTSRWlNKHS{ZXH0cYVvfCxiYX7kJJRp\SClb33ibY5ifGmxbh?= MlH5NlIyOTJ7NEC=
MDA-MB231 NVHKd3pqSXCxcITvd4l{KEG|c3H5 MVe1NOKh|ryP MX2yOIg> MkPFSG1UVw>? NInPdGhi[nKxZ3H0[ZMh[3W{Y4XtbY4ucW6mdXPl[EBk\WyuIHTlZZRp MmXLNlIyODF|M{W=
LNCaP M2fkRWFxd3C2b4Ppd{BCe3OjeR?= MXS1NOKh|ryP MlXHNlRp MoTVSG1UVw>? MlXRZYJzd2ejdHXzJIN2emO3bXnuMYlv\HWlZXSgZ4VtdCCmZXH0bC=> MnnqNlIyODF|M{W=
HCT116 NWLnPG1oSXCxcITvd4l{KEG|c3H5 NGnSN5I2OMLizszN MWeyOIg> M3TMemROW09? MYThZpJw\2G2ZYOgZ5Vz[3WvaX6tbY5lfWOnZDDj[YxtKGSnYYTo MnrpNlIyODF|M{W=
Ishikawa  MkXYRZBweHSxc3nzJGF{e2G7 NGHzPWwzPc7:TR?= M{LscFI1cA>? NFzyUoxz\WS3Y3XzJINmdGxiZHXheIgh[W6mIHHwc5B1d3OrczDpcoR2[2WmIHL5JGJi\iCDMR?= NF:4XYwzOjB6OEmxPC=>
 YD-8  MX\BdI9xfG:|aYOgRZN{[Xl? MorjNVAx|ryP NXf6Uot5OWh? NILndmFqdmirYnn0d{BRVEWRLXnu[JVk\WRiYYDvdJRwe2m| Mlu4NlIxQDZzOEO=
eosinophil  MVTBdI9xfG:|aYOgRZN{[Xl? NFe4Rlc6OM7:TR?= NUW4dZM1OjSq MlzrbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkhTmG|IHHueIljd2S7wrC= M1LzXFIzODd7M{O0
L929 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVmyMlXPxE1? NXe1OGJpOjSq MV3pcohq[mm2czD0bIUh\XiycnXzd4lwdiCxZjDwMZA{QCCjbnSgUmYu|rqEIITvJIF2\22nboSgWG5H|rFvaX7keYNm\CCwZXPyc5B1d3OrczDhcoQh[XW2b4DoZYd6 NGXLV5AzOjB{N{C5Oy=>
YD-8  MVzBdI9xfG:|aYOgRZN{[Xl? MYGxNFDPxE1? MkTUNYg> NX7weFg5[myxY3vzJJRp\SCJUz3IR4wucW6mdXPl[EBieG:ydH;zbZM> NGPLeWYzOjB{MEC3PC=>
HBx MmHPRZBweHSxc3nzJGF{e2G7 MmHsNlXPxE1? MmTwOFhp M4Ow[WROW09? M4q5UJJm\HWlZXSgZ4VtdCCmZXH0bEBqdmS3Y3XkJIJ6KDNvTVG= NIPpc|QzOjB{MEC3PC=>
U937  M1PaS2Fxd3C2b4Ppd{BCe3OjeR?= NEDNfFM2OMLizszN M4X4TlFp MUDpcohq[mm2czDISk1qdmS3Y3XkJIFxd3C2b4Ppd:Kh NV\QWJB6OjF7OUi3N|E>
HL60 M162UmFxd3C2b4Ppd{BCe3OjeR?= MnTqOFDPxE1? NF;kPZA1OG2rbh?= MXXEUXNQ M3TyRoJtd2OtczDCUmREKGOxbYDveY5leyCrbnT1Z4Uh\Xiyb4P1doUhd2ZicHjvd5Bp[XSrZInsd4VzcW6nIHHu[EBFVkFiZoLh[41mdnSjdHnvci=> NHX6XWMzOTl6M{K5Oi=>
M-14 MVjBdI9xfG:|aYOgRZN{[Xl? MWSyOe69VQ>? MXuwMlVp NV7ZeJdGyqCrbnjpZol1eyCkb4ToJJRp\SClcoXk[UBmgHS{YXP0MUBidmRiY3;tdI92dmRvaX7keYNm\CCjcH;weI9{cXN? M{HONVIyQTV2OUW5
SK-BR-3 MlrZRZBweHSxc3nzJGF{e2G7 M{TNSlUxyqEQvF2= NXLUfWFmOmh? NYftXox{[myxY3vzJIFxd3C2b4TpZ{BFVkFiZoLh[41mdnSjdHnvckBqdmS3Y3XkJIJ6KGOxbXLpcoF1cW:wIH;mJHNONTF4NDDhcoQhemGmaXH0bY9v MmXkNlE6ODF|OE[=
MDA-MB-468 MWLBdI9xfG:|aYOgRZN{[Xl? M4TxOlUxyqEQvF2= MofMNog> NEfzNnRjdG:la4OgZZBweHSxdHnjJGRPSSCocnHncYVvfGG2aX;uJIlv\HWlZXSgZpkh[2:vYnnuZZRqd25ib3[gV20uOTZ2IHHu[EBz[WSrYYTpc44> M{jkfVIyQTBzM{i2

多くの細胞株試験データを見る場合、クリックしてください

体内試験 In vivo Z-VAD-FMK administration has been shown previously to be nontoxic and to prevent apoptosis in animal models. Intraperitoneal HK-GBS injection leads to preterm delivery, and pretreatment with Z-VAD-FMK delays preterm delivery in mice. In OVA-sensitized mice,treatment of z-VAD-fmk inhibits allergen-induced leukocyte infiltration. Systemic injection of the pan-caspase inhibitor z-VAD-fmk immediately before OVA challenge reduced inflammatory cell accumulation, mucus hypersecretion, and Th2 cytokine release in OVA-sensitized/challenged mice. Treatment with z-VAD-fmk blocked terminal differentiation of lens epithelial cells and keratinocytes, the differentiation of monocytes into macrophages, and the differentiation of erythroid progenitors. z-VAD-fmk attenuated allergen-induced airway inflammation and hyperreactivity. Treatment with z-VAD-fmk in vivo also prevented subsequent T cell activation ex vivo[7].

お薦めの試験操作(参考用のみ)

細胞試験:

[6]

+ 展開
  • 細胞株: human granulosa cell lines (GC1a, HGL5, COV434)
  • 濃度: 50 μM
  • 反応時間: 48 h
  • 実験の流れ:

    To validate the efficacy of Z-VAD-FMK, three human granulosa cell lines (GC1a, HGL5, COV434) were treated for 48 h with etoposide (50 μg/ml) and/or Z-VAD-FMK (50 μM) under normoxic conditions. To mimic the ischemic phase that occurs after ovarian fragment transplantation, cells were cultured without serum under hypoxia (1 % O2) and treated with Z-VAD-FMK. The metabolic activity of the cells was evaluated by WST-1 assay. Cell viability was determined by FACS analyses. The expression of apoptosis-related molecules was assessed by RT-qPCR and Western blot analyses.


    (参考用のみ)
動物試験:

[7]

+ 展開
  • 動物モデル: CD1 mice
  • 製剤: dissolved in DMSO, diluted in PBS (final concentration of DMSO < 1%)
  • 投薬量: 10 mg/kg
  • 投与方法: i.p.
    (参考用のみ)

溶解度 (25°C)

化学情報

分子量 467.49
化学式

C22H30FN3O7

CAS No. 187389-52-2
保管
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    Can you suggest an in vivo formulation of S7023 for animal studies?

  • 回答:

    For in vivo study of S7023, The IP formulation is 2% DMSO+35 % PEG 300+2% Tween 80+ddH2O up to 6 mg/ml. The gavage formula is 1%CMC-Na up to 30 mg/ml (suspensions).

  • 質問2:

    What is difference between S7023 & S8102?

  • 回答:

    Unlike S7023, S8102 does not require pretreatment with esterase for in vitro studies. This information was cited from the article: https://www.ncbi.nlm.nih.gov/pubmed/16973565.

Caspaseシグナル伝達経路

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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID