S7061 |
GSK126
|
GSK126 (GSK2816126A、GSK2816126) は強力で選択性の高い EZH2 メチルトランスフェラーゼ (methyltransferase) 阻害剤(IC50=9.9 nM)であり、EZH2 に対して 20 種類以上の他のヒトメチルトランスフェラーゼよりも 1000 倍以上の選択性を持ちます。 |
-
Signal Transduct Target Ther, 2024, 9(1):2
-
Cell, 2023, 186(13):2765-2782.e28
-
Mol Cancer, 2023, 22(1):85
|
|
S7128 |
Tazemetostat (EPZ-6438)
|
Tazemetostat (EPZ-6438, E7438) is a potent, and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays, exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs. |
-
Signal Transduct Target Ther, 2024, 9(1):2
-
Nat Commun, 2024, 15(1):1367
-
Sci Rep, 2024, 14(1):4303
|
|
S7120 |
DZNeP (3-deazaneplanocin A) HCl
|
DZNeP (3-deazaneplanocin A) HCl, an analog of adenosine, is a competitive inhibitor of S-adenosylhomocysteine hydrolase with Ki of 50 pM in a cell-free assay. |
-
Mol Cancer, 2023, 22(1):85
-
Cell Stem Cell, 2023, 30(9):1235-1245.e6
-
Nat Commun, 2023, 14(1):4062
|
|
S7164 |
GSK343
|
GSK343 is a potent and selective EZH2 inhibitor with IC50 of 4 nM in a cell-free assay, showing 60 fold selectivity against EZH1, and >1000 fold selectivity against other histone methyltransferases. GSK343 induces autophagy. |
-
J Immunother Cancer, 2023, 11(11)e007736
-
Clin Transl Med, 2023, 13(12):e1502
-
J Neuroinflammation, 2023, 20(1):168
|
|
S7062 |
Pinometostat (EPZ5676)
|
Pinometostat (EPZ5676) is an S-adenosyl methionine (SAM) competitive inhibitor of protein methyltransferase DOT1L with Ki of 80 pM in a cell-free assay, demonstrating >37,000-fold selectivity against all other PMTs tested, inhibits H3K79 methylation in tumor. Phase 1. |
-
Exp Hematol Oncol, 2023, 12(1):81
-
EMBO Rep, 2023, e56233.
-
Life Sci Alliance, 2023, 6(5)e202201619
|
|
S8006 |
BIX 01294
|
BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM in a cell-free assay, reduces H3K9me2 of bulk histones, also weakly inhibits GLP (primarily H3K9me3), no significant activity observed at other histone methyltransferases. BIX01294 induces autophagy. BIX01294 also inhibits H3K36 methylation by oncoproteins NSD1, NSD2 and NSD3. |
-
Dev Cell, 2023, 58(6):506-521.e5
-
Cell Death Dis, 2023, 14(9):627
-
Cell Death Dis, 2023, 14(9):627
|
|
S7353 |
EPZ004777
|
EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM in a cell-free assay and demonstrates >1,200-fold selectivity for DOT1L over all other tested PMTs. EPZ004777 induces apoptosis. |
-
Cell Rep, 2023, 42(8):112885
-
Cell Rep, 2023, 42(6):112566
-
Int J Mol Sci, 2023, 24(11)9365
|
|
S7748 |
EPZ015666 (GSK3235025)
|
EPZ015666 (GSK3235025) is a potent, selective and orally bioavailable PRMT5 inhibitor with Ki of 5 nM, >20,000-fold selectivity over other PMTs.
|
-
Nat Commun, 2023, 14(1):4003
-
Mol Cell, 2023, 83(15):2810-2828.e6
-
Cell Rep Med, 2023, 4(12):101326
|
|
S7165 |
UNC1999
|
UNC1999 is a potent, orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM in cell-free assays, respectively, showing >1000-fold selectivity over a broad range of epigenetic and non-epigenetic targets. UNC1999 is a potent autophagy inducer. UNC1999 specifically suppresses H3K27me3/2 and induces a range of anti-leukemia effects including anti-proliferation, differentiation, and apoptosis. |
-
Acta Pharm Sin B, 2023, 13(6):2601-2612
-
J Exp Clin Cancer Res, 2023, 42(1):320
-
Pharmacol Res, 2022, 177:106122
|
|
S8496 |
EED226
|
EED226 is a potent, selective, and orally bioavailable a novel allosteric Polycomb repressive complex 2 (PRC2) inhibitor with an IC50 of 23.4 nM when the H3K27me0 peptide was used as substrate and an IC50 of 53.5 nM when the mononucleosome was used as the substrate. It directly binds to the H3K27me3 binding pocket of EED. |
-
Elife, 2023, 12e85365
-
Open Biol, 2023, 13(1):220211
-
Nat Commun, 2022, 13(1):4199
|
|
S7004 |
EPZ005687
|
EPZ005687 is a potent and selective inhibitor of EZH2 with Ki of 24 nM in a cell-free assay, 50-fold selectivity against EZH1 and 500-fold selectivity against 15 other protein methyltransferases. |
-
J Exp Clin Cancer Res, 2023, 42(1):320
-
BMC Med, 2022, 20(1):189
-
Cancers (Basel), 2022, 15(1)208
|
|
S8068 |
Chaetocin
|
Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively. Chaetocin is an anticancer agent and inhibitor of thioredoxin reductase (TrxR). |
-
Cancer Cell, 2023, 41(6):1118-1133.e12
-
Mol Ther, 2023, 10.1016/j.ymthe.2023.11.012
-
Clin Cancer Res, 2023, 29(1):271-278
|
|
S7079 |
SGC 0946
|
SGC 0946 is a highly potent and selective DOT1L methyltransferase inhibitor with IC50 of 0.3 nM in a cell-free assay, is inactive against a panel of 12 PMTs and DNMT1. |
-
bioRxiv, 2024, 2024.02.06.579191
-
Cell Rep, 2023, 42(8):112885
-
Cell Rep, 2023, 42(6):112566
|
|
S8664 |
Pemrametostat (GSK3326595)
|
Pemrametostat (GSK3326595, EPZ015938) is an orally active, potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) and potently inhibits tumor growth in vitro and in vivo in animal models. |
-
NPJ Precis Oncol, 2024, 8(1):52
-
Nat Metab, 2023, 10.1038/s42255-023-00861-4
-
Nat Metab, 2023, 5(9):1544-1562
|
|
S7265 |
MM-102
|
MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic MLL1 inhibitor with IC50 of 0.4 μM in a cell-free assay. |
-
Life Sci Alliance, 2023, 6(5)e202201619
-
Cell Stem Cell, 2022, S1934-5909(22)00417-9
-
Cell Rep, 2022, 39(7):110836
|
|
S8071 |
UNC0638
|
UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP histone methyltransferase with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets. UNC0638 has anti-viral activities. |
-
Cell Rep, 2024, 43(2):113779
-
Cell Rep, 2023, 42(6):112566
-
Cancer Cell, 2022, 40(10):1190-1206.e9
|
|
S7805 |
EPZ011989
|
EPZ011989 is a potent, selective, orally bioavailable EZH2 inhibitor with Ki of <3 nM. |
-
Cancers (Basel), 2024, 16(3):569.
-
Cancers (Basel), 2024, 16(3)569
-
Nat Cell Biol, 2023, 25(2):258-272
|
|
S7230 |
UNC0642
|
UNC0642 is a potent, selective inhibitor of histone methyltransferases G9a/GLP with IC50s less than 2.5 nM for G9a and GLP and shows more than 300-fold selective for G9a and GLP over a broad range of kinases, GPCRs, transporters, and ion channels. |
-
Cell Rep, 2024, 43(1):113575
-
Cancers (Basel), 2023, 15(8)2199
-
bioRxiv, 2023, 2023.07.11.548643
|
|
S7833 |
OICR-9429
|
OICR-9429 is a potent antagonist of the interaction of WDR5 with peptide regions of MLL and Histone 3 and reduces viability of acute myeloid leukemia cells in vitro. |
-
J Clin Invest, 2023, 133(13)e169993
-
EBioMedicine, 2023, 92:104602
-
Cell Rep, 2023, 42(9):113145
|
|
S7570 |
UNC0379
|
UNC0379 is a selective, substrate competitive inhibitor of N-lysine methyltransferase SETD8 with IC50 of 7.3 μM, high selectivity over 15 other methyltransferases. |
-
Cell Death Dis, 2023, 10.1038/s41419-023-06167-3
-
Cell Death Dis, 2023, 14(9):638
-
Cell Biosci, 2023, 13(1):107
|
|
S8111 |
GSK591
|
GSK591 (EPZ015866, GSK3203591) is a potent selective inhibitor of the arginine methyltransferase PRMT5 with IC50 of 11 nM. |
-
Int J Mol Sci, 2023, 24(5)4327
-
Proc Natl Acad Sci U S A, 2022, 119(43):e2205255119
-
Hepatology, 2021, 10.1002/hep.32245
|
|
S8353 |
Lirametostat (CPI-1205)
|
Lirametostat (CPI-1205) is an orally available selective inhibitor of the histone lysine methyltransferase EZH2, with potential antineoplastic activity. |
-
JCI Insight, 2022, e155899
-
Cancer Discov, 2021, candisc.0913.2020
-
Nat Commun, 2021, 12(1):6276
|
|
S7618 |
MI-2 (Menin-MLL Inhibitor)
|
MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.
|
-
Cell Stem Cell, 2022, S1934-5909(22)00417-9
-
Life Sci Alliance, 2022, 5(4)e202101187
-
J Immunol, 2021, ji1901348
|
|
S7616 |
CPI-169
|
CPI-169 is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively. |
-
J Exp Clin Cancer Res, 2023, 42(1):96
-
Nat Commun, 2022, 13(1):6226
-
Nat Commun, 2022, 13(1):6226
|
|
S7817 |
MI-503
|
MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines(GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations. |
-
Nat Cell Biol, 2023, 25(2):258-272
-
J Clin Invest, 2023, 133(13)e169993
-
Breast Cancer Res, 2022, 24(1):52
|
|
S8112 |
MS023
|
MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively.
|
-
Sci Rep, 2024, 14(1):4303
-
Journal of Pharmacological Sciences, 2024, Pages 209-217
-
Nat Commun, 2023, 14(1):2806
|
|
S7983 |
A-196
|
A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective over other histone methyltransferases and non-epigenetic targets.
|
-
iScience, 2023, 26(3):106158
-
Cancer Res, 2022, 82(8):1534-1547
-
Sci Total Environ, 2022, 838(Pt 1):155713
|
|
S7804 |
GSK503
|
GSK503 is a potent and specific EZH2 methyltransferase inhibitor.
|
-
Int J Mol Sci, 2023, 24(10)8603
-
Cancer Res, 2022, CAN-22-0736
-
Front Genet, 2022, 13:1013475
|
|
S7884 |
AMI-1
|
AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively.
|
-
Cell Death Dis, 2023, 14(4):233
-
Oncogenesis, 2022, 11(1):45
-
Oncogene, 2021, 40(7):1375-1389
|
|
S7294 |
PFI-2 HCl
|
PFI-2 is a potent, selective, and cell-active lysine methyltransferase SETD7 inhibitor with Ki (app) and IC50 of 0.33 nM and 2 nM, 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.
|
-
Life Sci Alliance, 2023, 6(5)e202201619
-
Pharmacol Res, 2022, 177:106122
-
Cell Rep, 2022, 39(12):110994
|
|
S7832 |
SGC707
|
SGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) with IC50 and Kd of 31 nM and 53 nM, respectively.
|
-
Cell Death Dis, 2022, 13(11):943
-
J Med Chem, 2020, 31
-
Transpl Int, 2020, 33(2):229-243
|
|
S7572 |
A-366
|
A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor with IC50 of 3.3nM and 38nM, exhibiting >1000-fold selectivity for G9a/GLP over 21 other methyltransferases. |
-
Cell Rep, 2024, 43(1):113575
-
Cancers (Basel), 2023, 15(8)2199
-
Cancer Cell, 2022, 40(10):1190-1206.e9
|
|
S4589 |
Amodiaquine dihydrochloride dihydrate
|
Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase in human erythrocytes, also used as an antimalarial and anti-inflammatory agent. |
-
Cell Death Differ, 2023, 10.1038/s41418-023-01167-4
-
Nat Biomed Eng, 2021, 10.1038/s41551-021-00718-9
-
J Med Chem, 2020, 31
|
|
S7619 |
MI-3 (Menin-MLL Inhibitor)
|
MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM.
|
-
Nat Commun, 2023, 14(1):3062
-
Nature, 2021, 10.1038/s41586-021-04116-8
-
Clin Epigenetics, 2019, 11(1):137
|
|
S7591 |
BRD4770
|
BRD4770 is a histone methyltransferase G9a inhibitor with IC50 of 6.3 μM, and induces cell senescence.
|
-
Hum Cell, 2023, 10.1007/s13577-023-00924-4
-
Cell Insight, 2023, 2(4):100112
-
Pharmacol Res, 2022, 177:106122
|
|
S7575 |
LLY-507
|
LLY-507 is a cell-active, potent, and selective inhibitor of protein-lysine Methyltransferase SMYD2. |
-
Pharmacol Res, 2022, 177:106122
-
Oncol Lett, 2020, 20(5):153
-
J Immunother Cancer, 2019, 7(1):277
|
|
S8624 |
Onametostat (JNJ-64619178)
|
Onametostat (JNJ-64619178) is a PRMT5 inhibitor with high selectivity and potency (subnanomolar range, PRMT5-MEP-50 IC50=0.14 nM) under different in vitro and cellular conditions, paired with favorable pharmacokinetics and safety properties.
|
-
Sci Rep, 2024, 14(1):4303
-
Nat Commun, 2023, 14(1):1078
-
J Immunother Cancer, 2023, 11(6)e006890
|
|
S2184 |
WDR5-0103
|
WDR5-0103 is a small-molecule antagonist of WDR5 (WD40 repeat protein 5) with Kd of 450 nM. |
-
J Clin Invest, 2023, 133(13)e169993
-
Cell Rep, 2023, 42(9):113145
-
Biomed Pharmacother, 2022, 154:113663
|
|
S7611 |
EI1
|
EI1 is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively.
|
-
Cancer Res, 2018, 78(20):5731-5740
-
Mol Cancer, 2017, 10.1186/s12943-016-0575-6
-
Virology, 2017, 506:34-44
|
|
S4021 |
Tolcapone
|
Tolcapone (Ro 40-7592) is a selective, potent and reversible of catechol-O-methyl transferase (COMT) inhibitor with Ki of 30 nM. |
-
FASEB J, 2022, 36(7):e22399
-
Viruses, 2021, 13(8)1533
-
Front Bioinform, 2021, 1:710591
|
|
S8359 |
UNC3866
|
UNC3866 is a potent antagonist of the methyllysine (Kme) reading function of the Polycomb CBX and CDY families of chromodomains. UNC3866 binds the chromodomains of CBX4 and CBX7 most potently, with a K(d) of ∼100 nM for each, and is 6- to 18-fold selective as compared to seven other CBX and CDY chromodomains. |
-
Leukemia, 2021, 10.1038/s41375-021-01121-8
-
Leukemia, 2021, 10.1038/s41375-021-01121-8
-
Int J Mol Sci, 2021, 22(2)E619
|
|
S7820 |
EPZ020411 2HCl
|
EPZ020411 is a potent and selective small molecule PRMT6 inhibitor with an IC50 of 10 nM. |
-
Nat Commun, 2023, 14(1):1430
-
Inflamm Res, 2022, 71(3):309-320
-
Theranostics, 2020, 10(1):133-150
|
|
S7816 |
MI-463
|
MI-463 is a potent inhibitor of Menin-MLL interaction with an IC50 value of 15.3 nM. |
-
J Clin Invest, 2023, 133(13)e169993
-
iScience, 2023, 26(10):107726
-
Front Oncol, 2020, 10:524922
|
|
S8209 |
HLCL-61 HCL
|
HLCL-61 hydrochloride is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia. |
-
Front Immunol, 2019, 10:174
-
Nat Commun, 2018, 9(1):1572
-
Cancer Res, 2018, 78(20):5731-5740
|
|
S8983 |
MAK683
|
MAK683 (EED inhibitor-1, example 2) is an inhibitor of embryonic ectoderm development (EED). MAK683 exhibits IC50 of 59 nM, 89 nM and 26 nM in EED Alphascreen binding, LC-MS and ELISA assay, respectively. |
-
PLoS Biol, 2023, 21(4):e3002038
-
Cell Death Dis, 2022, 13(2):155
-
JCI Insight, 2022, e155899
|
|
S7815 |
MI-136
|
MI-136 can specifically inhibit the menin-MLL interaction. It inhibits DHT-induced expression of androgen receptor (AR) target genes. |
-
Breast Cancer Res, 2022, 24(1):52
-
Cancer Cell Int, 2022, 22(1):336
-
J Med Chem, 2020, 31
|
|
S3147 |
Entacapone
|
Entacapone (OR-611) inhibits catechol-O-methyltransferase(COMT) with IC50 of 151 nM. Entacapone can be used for the research of Parkinson's disease. Entacapone serves as a inhibitor of FTO demethylation with an IC50 of 3.5 μM, can be used for the research of metabolic disorders. |
-
Elife, 2022, 11e72668
-
bioRxiv, 2021, 10.1101/2021.03.22.436393
|
|
S8147 |
MS049
|
MS049 is a potent and selective inhibitor of PRMT4 and PRMT6 with IC50s of 34 nM and 43 nM, respectively. |
-
Research Square, 2021, 10.21203/rs.3.rs-620216/v1
-
EMBO Rep, 2020, 21(2):e48597
|
|
S7868 |
SAH (S-Adenosyl-L-homocysteine)
|
SAH (S-Adenosyl-L-homocysteine) is an inhibitor for (Methyltransferase Like 3-14) METTL3-METTL14 heterodimer complex (METTL3-14) with IC50 of 0.9 μM. |
-
Clin Epigenetics, 2024, 16(1):18
-
Heliyon, 2023, 9(6):e16905
-
J Pept Sci, 2022, e3456.
|
|
S8934 |
VTP50469
|
VTP50469 is a potent, highly selective and orally active inhibitor of Menin-MLL interaction with Ki of 104 pM. VTP50469 exhibits anti-leukemia activity. |
-
Cell Rep, 2023, 42(6):112547
-
bioRxiv, 2023, 10.1101/2023.03.17.533231
|
|
S8494 |
PF-06726304
|
PF-06726304 is a selective EZH2 inhibitor with Ki values of 0.7 nM and 3 nM for WT EZH2 and Y641N respectively; also inhibits H3K27me3 with the IC50 value of 15 nM.
|
-
Nat Commun, 2023, 10.1038/s41467-023-42930-y
-
Elife, 2021, 10e65654
|
|
S7656 |
CPI-360
|
CPI-360 is a potent, selective,and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases.
|
-
Mol Ther Oncolytics, 2022, 27:14-25
-
Cancer Res, 2018, 78(20):5731-5740
|
|
S8607 |
JQ-EZ-05 (JQEZ5)
|
JQ-EZ-05 (JQEZ5) is a specific and reversible EZH1/2 inhibitor. |
-
Nat Chem Biol, 2019, 15(4):391-400
|
|
S8340 |
SGC2085
|
SGC2085 is a potent and selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) inhibitor with an IC50 value of 50 nM and >100-fold selective over other PRMTs.
|
-
Cell Rep, 2022, 39(12):110994
|
|
S7020 |
UNC0646
|
UNC0646 is a selective histone lysine methyltransferase (HMTase) inhibitor for G9a and GLP with IC50 of 6 nM and 15 nM , respectively, with excellent potency in a variety of cell lines and excellent separation of functional potency versus cell toxicity. |
|
|
E1163New |
MS177
|
MS177 is an EZH2-targeting PRTOAC degrader and a potent inhibitor of enzymatic EZH2, that effectively depletes both canonical EZH2–PRC2 and noncanonical EZH2–cMyc complexes. MS177 induces leukemia cell growth inhibition, apoptosis, and cell cycle progression arrest. |
|
|
S5445 |
AMI-1 (free acid)
|
AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively. |
|
|
S8918 |
MS1943
|
MS1943 is an orally bioavailable EZH2 selective degrader that effectively reduces EZH2 levels in cells with IC50 of 120 nM for inhibiting EZH2 methyltransferase activity. |
|
|
E2911New |
UZH2
|
UZH2 is a potent and selective METTL3 inhibitor with an IC50 value of 5 nM in TR-FRET assay. |
|
|
S8702 |
EBI-2511
|
EBI-2511 is a highly potent and orally active EZH2 inhibitor with an IC50 of 4 nM for EZH2(A667G). |
|
|
S9659 |
UNC6852
|
UNC6852 is a selective degrader that targets polycomb repressive complex 2 (PRC2) with IC50 of 247 nM for EED. UNC6852 is based on PROTAC and contains an EED226-derived ligand and a ligand for VHL. |
|
|
S7061 |
GSK126
|
GSK126 (GSK2816126A、GSK2816126) は強力で選択性の高い EZH2 メチルトランスフェラーゼ (methyltransferase) 阻害剤(IC50=9.9 nM)であり、EZH2 に対して 20 種類以上の他のヒトメチルトランスフェラーゼよりも 1000 倍以上の選択性を持ちます。 |
- Signal Transduct Target Ther, 2024, 9(1):2
- Cell, 2023, 186(13):2765-2782.e28
- Mol Cancer, 2023, 22(1):85
|
|
S7128 |
Tazemetostat (EPZ-6438)
|
Tazemetostat (EPZ-6438, E7438) is a potent, and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays, exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs. |
- Signal Transduct Target Ther, 2024, 9(1):2
- Nat Commun, 2024, 15(1):1367
- Sci Rep, 2024, 14(1):4303
|
|
S7120 |
DZNeP (3-deazaneplanocin A) HCl
|
DZNeP (3-deazaneplanocin A) HCl, an analog of adenosine, is a competitive inhibitor of S-adenosylhomocysteine hydrolase with Ki of 50 pM in a cell-free assay. |
- Mol Cancer, 2023, 22(1):85
- Cell Stem Cell, 2023, 30(9):1235-1245.e6
- Nat Commun, 2023, 14(1):4062
|
|
S7164 |
GSK343
|
GSK343 is a potent and selective EZH2 inhibitor with IC50 of 4 nM in a cell-free assay, showing 60 fold selectivity against EZH1, and >1000 fold selectivity against other histone methyltransferases. GSK343 induces autophagy. |
- J Immunother Cancer, 2023, 11(11)e007736
- Clin Transl Med, 2023, 13(12):e1502
- J Neuroinflammation, 2023, 20(1):168
|
|
S7062 |
Pinometostat (EPZ5676)
|
Pinometostat (EPZ5676) is an S-adenosyl methionine (SAM) competitive inhibitor of protein methyltransferase DOT1L with Ki of 80 pM in a cell-free assay, demonstrating >37,000-fold selectivity against all other PMTs tested, inhibits H3K79 methylation in tumor. Phase 1. |
- Exp Hematol Oncol, 2023, 12(1):81
- EMBO Rep, 2023, e56233.
- Life Sci Alliance, 2023, 6(5)e202201619
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S8006 |
BIX 01294
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BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM in a cell-free assay, reduces H3K9me2 of bulk histones, also weakly inhibits GLP (primarily H3K9me3), no significant activity observed at other histone methyltransferases. BIX01294 induces autophagy. BIX01294 also inhibits H3K36 methylation by oncoproteins NSD1, NSD2 and NSD3. |
- Dev Cell, 2023, 58(6):506-521.e5
- Cell Death Dis, 2023, 14(9):627
- Cell Death Dis, 2023, 14(9):627
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S7353 |
EPZ004777
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EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM in a cell-free assay and demonstrates >1,200-fold selectivity for DOT1L over all other tested PMTs. EPZ004777 induces apoptosis. |
- Cell Rep, 2023, 42(8):112885
- Cell Rep, 2023, 42(6):112566
- Int J Mol Sci, 2023, 24(11)9365
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S7748 |
EPZ015666 (GSK3235025)
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EPZ015666 (GSK3235025) is a potent, selective and orally bioavailable PRMT5 inhibitor with Ki of 5 nM, >20,000-fold selectivity over other PMTs.
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- Nat Commun, 2023, 14(1):4003
- Mol Cell, 2023, 83(15):2810-2828.e6
- Cell Rep Med, 2023, 4(12):101326
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S7165 |
UNC1999
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UNC1999 is a potent, orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM in cell-free assays, respectively, showing >1000-fold selectivity over a broad range of epigenetic and non-epigenetic targets. UNC1999 is a potent autophagy inducer. UNC1999 specifically suppresses H3K27me3/2 and induces a range of anti-leukemia effects including anti-proliferation, differentiation, and apoptosis. |
- Acta Pharm Sin B, 2023, 13(6):2601-2612
- J Exp Clin Cancer Res, 2023, 42(1):320
- Pharmacol Res, 2022, 177:106122
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S7004 |
EPZ005687
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EPZ005687 is a potent and selective inhibitor of EZH2 with Ki of 24 nM in a cell-free assay, 50-fold selectivity against EZH1 and 500-fold selectivity against 15 other protein methyltransferases. |
- J Exp Clin Cancer Res, 2023, 42(1):320
- BMC Med, 2022, 20(1):189
- Cancers (Basel), 2022, 15(1)208
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S8068 |
Chaetocin
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Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively. Chaetocin is an anticancer agent and inhibitor of thioredoxin reductase (TrxR). |
- Cancer Cell, 2023, 41(6):1118-1133.e12
- Mol Ther, 2023, 10.1016/j.ymthe.2023.11.012
- Clin Cancer Res, 2023, 29(1):271-278
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S7079 |
SGC 0946
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SGC 0946 is a highly potent and selective DOT1L methyltransferase inhibitor with IC50 of 0.3 nM in a cell-free assay, is inactive against a panel of 12 PMTs and DNMT1. |
- bioRxiv, 2024, 2024.02.06.579191
- Cell Rep, 2023, 42(8):112885
- Cell Rep, 2023, 42(6):112566
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S8664 |
Pemrametostat (GSK3326595)
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Pemrametostat (GSK3326595, EPZ015938) is an orally active, potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) and potently inhibits tumor growth in vitro and in vivo in animal models. |
- NPJ Precis Oncol, 2024, 8(1):52
- Nat Metab, 2023, 10.1038/s42255-023-00861-4
- Nat Metab, 2023, 5(9):1544-1562
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S7265 |
MM-102
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MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic MLL1 inhibitor with IC50 of 0.4 μM in a cell-free assay. |
- Life Sci Alliance, 2023, 6(5)e202201619
- Cell Stem Cell, 2022, S1934-5909(22)00417-9
- Cell Rep, 2022, 39(7):110836
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S8071 |
UNC0638
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UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP histone methyltransferase with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets. UNC0638 has anti-viral activities. |
- Cell Rep, 2024, 43(2):113779
- Cell Rep, 2023, 42(6):112566
- Cancer Cell, 2022, 40(10):1190-1206.e9
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S7805 |
EPZ011989
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EPZ011989 is a potent, selective, orally bioavailable EZH2 inhibitor with Ki of <3 nM. |
- Cancers (Basel), 2024, 16(3):569.
- Cancers (Basel), 2024, 16(3)569
- Nat Cell Biol, 2023, 25(2):258-272
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S7230 |
UNC0642
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UNC0642 is a potent, selective inhibitor of histone methyltransferases G9a/GLP with IC50s less than 2.5 nM for G9a and GLP and shows more than 300-fold selective for G9a and GLP over a broad range of kinases, GPCRs, transporters, and ion channels. |
- Cell Rep, 2024, 43(1):113575
- Cancers (Basel), 2023, 15(8)2199
- bioRxiv, 2023, 2023.07.11.548643
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S7570 |
UNC0379
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UNC0379 is a selective, substrate competitive inhibitor of N-lysine methyltransferase SETD8 with IC50 of 7.3 μM, high selectivity over 15 other methyltransferases. |
- Cell Death Dis, 2023, 10.1038/s41419-023-06167-3
- Cell Death Dis, 2023, 14(9):638
- Cell Biosci, 2023, 13(1):107
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S8111 |
GSK591
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GSK591 (EPZ015866, GSK3203591) is a potent selective inhibitor of the arginine methyltransferase PRMT5 with IC50 of 11 nM. |
- Int J Mol Sci, 2023, 24(5)4327
- Proc Natl Acad Sci U S A, 2022, 119(43):e2205255119
- Hepatology, 2021, 10.1002/hep.32245
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S8353 |
Lirametostat (CPI-1205)
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Lirametostat (CPI-1205) is an orally available selective inhibitor of the histone lysine methyltransferase EZH2, with potential antineoplastic activity. |
- JCI Insight, 2022, e155899
- Cancer Discov, 2021, candisc.0913.2020
- Nat Commun, 2021, 12(1):6276
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S7618 |
MI-2 (Menin-MLL Inhibitor)
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MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.
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- Cell Stem Cell, 2022, S1934-5909(22)00417-9
- Life Sci Alliance, 2022, 5(4)e202101187
- J Immunol, 2021, ji1901348
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S7616 |
CPI-169
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CPI-169 is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively. |
- J Exp Clin Cancer Res, 2023, 42(1):96
- Nat Commun, 2022, 13(1):6226
- Nat Commun, 2022, 13(1):6226
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S7817 |
MI-503
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MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines(GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations. |
- Nat Cell Biol, 2023, 25(2):258-272
- J Clin Invest, 2023, 133(13)e169993
- Breast Cancer Res, 2022, 24(1):52
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S8112 |
MS023
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MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively.
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- Sci Rep, 2024, 14(1):4303
- Journal of Pharmacological Sciences, 2024, Pages 209-217
- Nat Commun, 2023, 14(1):2806
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S7983 |
A-196
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A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective over other histone methyltransferases and non-epigenetic targets.
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- iScience, 2023, 26(3):106158
- Cancer Res, 2022, 82(8):1534-1547
- Sci Total Environ, 2022, 838(Pt 1):155713
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S7804 |
GSK503
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GSK503 is a potent and specific EZH2 methyltransferase inhibitor.
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- Int J Mol Sci, 2023, 24(10)8603
- Cancer Res, 2022, CAN-22-0736
- Front Genet, 2022, 13:1013475
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S7884 |
AMI-1
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AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively.
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- Cell Death Dis, 2023, 14(4):233
- Oncogenesis, 2022, 11(1):45
- Oncogene, 2021, 40(7):1375-1389
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S7294 |
PFI-2 HCl
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PFI-2 is a potent, selective, and cell-active lysine methyltransferase SETD7 inhibitor with Ki (app) and IC50 of 0.33 nM and 2 nM, 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.
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- Life Sci Alliance, 2023, 6(5)e202201619
- Pharmacol Res, 2022, 177:106122
- Cell Rep, 2022, 39(12):110994
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S7832 |
SGC707
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SGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) with IC50 and Kd of 31 nM and 53 nM, respectively.
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- Cell Death Dis, 2022, 13(11):943
- J Med Chem, 2020, 31
- Transpl Int, 2020, 33(2):229-243
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S7572 |
A-366
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A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor with IC50 of 3.3nM and 38nM, exhibiting >1000-fold selectivity for G9a/GLP over 21 other methyltransferases. |
- Cell Rep, 2024, 43(1):113575
- Cancers (Basel), 2023, 15(8)2199
- Cancer Cell, 2022, 40(10):1190-1206.e9
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S4589 |
Amodiaquine dihydrochloride dihydrate
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Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase in human erythrocytes, also used as an antimalarial and anti-inflammatory agent. |
- Cell Death Differ, 2023, 10.1038/s41418-023-01167-4
- Nat Biomed Eng, 2021, 10.1038/s41551-021-00718-9
- J Med Chem, 2020, 31
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S7619 |
MI-3 (Menin-MLL Inhibitor)
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MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM.
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- Nat Commun, 2023, 14(1):3062
- Nature, 2021, 10.1038/s41586-021-04116-8
- Clin Epigenetics, 2019, 11(1):137
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S7591 |
BRD4770
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BRD4770 is a histone methyltransferase G9a inhibitor with IC50 of 6.3 μM, and induces cell senescence.
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- Hum Cell, 2023, 10.1007/s13577-023-00924-4
- Cell Insight, 2023, 2(4):100112
- Pharmacol Res, 2022, 177:106122
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S7575 |
LLY-507
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LLY-507 is a cell-active, potent, and selective inhibitor of protein-lysine Methyltransferase SMYD2. |
- Pharmacol Res, 2022, 177:106122
- Oncol Lett, 2020, 20(5):153
- J Immunother Cancer, 2019, 7(1):277
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S8624 |
Onametostat (JNJ-64619178)
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Onametostat (JNJ-64619178) is a PRMT5 inhibitor with high selectivity and potency (subnanomolar range, PRMT5-MEP-50 IC50=0.14 nM) under different in vitro and cellular conditions, paired with favorable pharmacokinetics and safety properties.
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- Sci Rep, 2024, 14(1):4303
- Nat Commun, 2023, 14(1):1078
- J Immunother Cancer, 2023, 11(6)e006890
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S7611 |
EI1
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EI1 is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively.
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- Cancer Res, 2018, 78(20):5731-5740
- Mol Cancer, 2017, 10.1186/s12943-016-0575-6
- Virology, 2017, 506:34-44
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S4021 |
Tolcapone
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Tolcapone (Ro 40-7592) is a selective, potent and reversible of catechol-O-methyl transferase (COMT) inhibitor with Ki of 30 nM. |
- FASEB J, 2022, 36(7):e22399
- Viruses, 2021, 13(8)1533
- Front Bioinform, 2021, 1:710591
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S7820 |
EPZ020411 2HCl
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EPZ020411 is a potent and selective small molecule PRMT6 inhibitor with an IC50 of 10 nM. |
- Nat Commun, 2023, 14(1):1430
- Inflamm Res, 2022, 71(3):309-320
- Theranostics, 2020, 10(1):133-150
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S7816 |
MI-463
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MI-463 is a potent inhibitor of Menin-MLL interaction with an IC50 value of 15.3 nM. |
- J Clin Invest, 2023, 133(13)e169993
- iScience, 2023, 26(10):107726
- Front Oncol, 2020, 10:524922
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S8209 |
HLCL-61 HCL
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HLCL-61 hydrochloride is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia. |
- Front Immunol, 2019, 10:174
- Nat Commun, 2018, 9(1):1572
- Cancer Res, 2018, 78(20):5731-5740
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S8983 |
MAK683
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MAK683 (EED inhibitor-1, example 2) is an inhibitor of embryonic ectoderm development (EED). MAK683 exhibits IC50 of 59 nM, 89 nM and 26 nM in EED Alphascreen binding, LC-MS and ELISA assay, respectively. |
- PLoS Biol, 2023, 21(4):e3002038
- Cell Death Dis, 2022, 13(2):155
- JCI Insight, 2022, e155899
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S7815 |
MI-136
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MI-136 can specifically inhibit the menin-MLL interaction. It inhibits DHT-induced expression of androgen receptor (AR) target genes. |
- Breast Cancer Res, 2022, 24(1):52
- Cancer Cell Int, 2022, 22(1):336
- J Med Chem, 2020, 31
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S3147 |
Entacapone
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Entacapone (OR-611) inhibits catechol-O-methyltransferase(COMT) with IC50 of 151 nM. Entacapone can be used for the research of Parkinson's disease. Entacapone serves as a inhibitor of FTO demethylation with an IC50 of 3.5 μM, can be used for the research of metabolic disorders. |
- Elife, 2022, 11e72668
- bioRxiv, 2021, 10.1101/2021.03.22.436393
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S8147 |
MS049
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MS049 is a potent and selective inhibitor of PRMT4 and PRMT6 with IC50s of 34 nM and 43 nM, respectively. |
- Research Square, 2021, 10.21203/rs.3.rs-620216/v1
- EMBO Rep, 2020, 21(2):e48597
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S7868 |
SAH (S-Adenosyl-L-homocysteine)
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SAH (S-Adenosyl-L-homocysteine) is an inhibitor for (Methyltransferase Like 3-14) METTL3-METTL14 heterodimer complex (METTL3-14) with IC50 of 0.9 μM. |
- Clin Epigenetics, 2024, 16(1):18
- Heliyon, 2023, 9(6):e16905
- J Pept Sci, 2022, e3456.
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S8934 |
VTP50469
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VTP50469 is a potent, highly selective and orally active inhibitor of Menin-MLL interaction with Ki of 104 pM. VTP50469 exhibits anti-leukemia activity. |
- Cell Rep, 2023, 42(6):112547
- bioRxiv, 2023, 10.1101/2023.03.17.533231
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S8494 |
PF-06726304
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PF-06726304 is a selective EZH2 inhibitor with Ki values of 0.7 nM and 3 nM for WT EZH2 and Y641N respectively; also inhibits H3K27me3 with the IC50 value of 15 nM.
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- Nat Commun, 2023, 10.1038/s41467-023-42930-y
- Elife, 2021, 10e65654
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S7656 |
CPI-360
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CPI-360 is a potent, selective,and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases.
|
- Mol Ther Oncolytics, 2022, 27:14-25
- Cancer Res, 2018, 78(20):5731-5740
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S8607 |
JQ-EZ-05 (JQEZ5)
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JQ-EZ-05 (JQEZ5) is a specific and reversible EZH1/2 inhibitor. |
- Nat Chem Biol, 2019, 15(4):391-400
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S8340 |
SGC2085
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SGC2085 is a potent and selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) inhibitor with an IC50 value of 50 nM and >100-fold selective over other PRMTs.
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- Cell Rep, 2022, 39(12):110994
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S7020 |
UNC0646
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UNC0646 is a selective histone lysine methyltransferase (HMTase) inhibitor for G9a and GLP with IC50 of 6 nM and 15 nM , respectively, with excellent potency in a variety of cell lines and excellent separation of functional potency versus cell toxicity. |
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E1163New |
MS177
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MS177 is an EZH2-targeting PRTOAC degrader and a potent inhibitor of enzymatic EZH2, that effectively depletes both canonical EZH2–PRC2 and noncanonical EZH2–cMyc complexes. MS177 induces leukemia cell growth inhibition, apoptosis, and cell cycle progression arrest. |
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S5445 |
AMI-1 (free acid)
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AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively. |
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S8918 |
MS1943
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MS1943 is an orally bioavailable EZH2 selective degrader that effectively reduces EZH2 levels in cells with IC50 of 120 nM for inhibiting EZH2 methyltransferase activity. |
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E2911New |
UZH2
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UZH2 is a potent and selective METTL3 inhibitor with an IC50 value of 5 nM in TR-FRET assay. |
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S8702 |
EBI-2511
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EBI-2511 is a highly potent and orally active EZH2 inhibitor with an IC50 of 4 nM for EZH2(A667G). |
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S9659 |
UNC6852
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UNC6852 is a selective degrader that targets polycomb repressive complex 2 (PRC2) with IC50 of 247 nM for EED. UNC6852 is based on PROTAC and contains an EED226-derived ligand and a ligand for VHL. |
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