デヒドロゲナーゼ

信号経路図

研究分野

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1501 Mycophenolate Mofetil <1 mg/mL 86 mg/mL <1 mg/mL
S2776 CPI-613 <1 mg/mL 77 mg/mL 77 mg/mL
S1247 Leflunomide <1 mg/mL 54 mg/mL 54 mg/mL
S2487 Mycophenolic acid <1 mg/mL 64 mg/mL 5 mg/mL
S7185 AGI-5198 <1 mg/mL 24 mg/mL 14 mg/mL
S8619 NCT-503 <1 mg/mL 81 mg/mL 81 mg/mL
S8611 Vorasidenib (AG-881) <1 mg/mL 82 mg/mL 82 mg/mL
S8615 Sodium dichloroacetate (DCA) 30 mg/mL 30 mg/mL 30 mg/mL
S8405 RRx-001 <1 mg/mL 53 mg/mL 23 mg/mL
S8382 ML390 <1 mg/mL 81 mg/mL 60 mg/mL
S1158 MK-8245 <1 mg/mL 93 mg/mL <1 mg/mL
S1680 Disulfiram <1 mg/mL 59 mg/mL 59 mg/mL
S1404 Trilostane <1 mg/mL 65 mg/mL <1 mg/mL
S4169 Teriflunomide <1 mg/mL 32 mg/mL ,1 mg/mL
S8076 PluriSIn #1 (NSC 14613) <1 mg/mL 43 mg/mL <1 mg/mL
S2376 Ammonium Glycyrrhizinate 5 mg/mL 168 mg/mL <1 mg/mL
S2055 Gimeracil <1 mg/mL 29 mg/mL <1 mg/mL
S4116 Isovaleramide <1 mg/mL 20 mg/mL 20 mg/mL
S7900 SW033291 <1 mg/mL 83 mg/mL 32 mg/mL
S7241 AGI-6780 <1 mg/mL 96 mg/mL 96 mg/mL
S7941 NCT-501 <1 mg/mL 32 mg/mL 25 mg/mL
S2289 Daidzin <1 mg/mL 83 mg/mL 4 mg/mL
S7262 Vidofludimus <1 mg/mL 100 mg/mL 1 mg/mL
S2295 Emodin <1 mg/mL 54 mg/mL 2 mg/mL
S2296 Enoxolone <1 mg/mL 94 mg/mL <1 mg/mL
S2302 Glycyrrhizin (Glycyrrhizic Acid) <1 mg/mL 100 mg/mL 100 mg/mL
S2303 gossypol-Acetic acid <1 mg/mL 100 mg/mL 10 mg/mL
S8206 AG-120 <1 mg/mL 100 mg/mL 100 mg/mL
S8205 AG-221 (Enasidenib) <1 mg/mL 94 mg/mL 94 mg/mL
製品コード 製品説明 文献中の使用例 お客様のフィードバック
S1501

Mycophenolate Mofetil

Mycophenolate mofetilは、活発な免疫抑制薬、更にはイノシン・モノリン酸塩デヒドロゲナーゼの非競争的で、選択的で、可逆的な阻害剤です。

S2776

CPI-613

CPI-613は、ミトコンドリア酵素ピルビン酸塩デヒドロゲナーゼ(PDH)とαケトグルタル酸のデヒドロゲナーゼを目標とするリポ酸の類似体です。

S1247

Leflunomide

Leflunomide is an immunosuppressant agent. Its active metabolite is Teriflunomide.

S2487

Mycophenolic acid

Mycophenolic acid is an immunosuppressant agent used to prevent rejection in organ transplantation.

S7185

AGI-5198

AGI-5198はIDH1 R132H/R132Cの突然変異体の最初の非常に強力かつ選択的な阻害剤で、 IC50 が 0.07 μM/0.16 μMです。

S8619

NCT-503

S8611

Vorasidenib (AG-881)

S8615

Sodium dichloroacetate (DCA)

S8405

RRx-001

S8382

ML390

S1158

MK-8245

MK-8245は、ネズミSCD1とマウスSCD1のために人間のSCD1と3nM 1nMのIC50値で肝臓を目標とするstearoyl-CoAデサチュラーゼ(SCD)の阻害剤です。

S1680

Disulfiram

Disulfiram is an agent used to support the treatment of chronic alcoholism by producing an acute sensitivity to alcohol.

S1404

Trilostane

Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase used in the treatment of Cushing’s syndrome.

S4169

Teriflunomide

Teriflunomideは、免疫調節剤として用いられる酵素ジヒドロデヒドロゲナーゼを遮断することによってレフルノミド、阻害ピリミジンデノボ合成の活性代謝産物です。

S8076

PluriSIn #1 (NSC 14613)

PluriSIn #1 (NSC 14613) is an inhibitor of the stearoyl-coA desaturase 1 (SCD1), which is able to selectively eliminate hPSCs.

S2376

Ammonium Glycyrrhizinate

Ammonium Glycyrrhizinate is a unique product derived from Licorice root and has an extremely sweet taste.

S2055

Gimeracil

Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the early step in homologous recombination for double strand breaks repair.

S4116

Isovaleramide

Isovaleramideは、カノコpavoniiから単離された抗痙攣分子であり、それは、肝臓のアルコールデヒドロゲナーゼを阻害します。

S7900

SW033291

SW033291 is a selective inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) with IC50 and Kiapp of 1.5 nM and 0.1 nM, respectively.

S7241

AGI-6780

AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant with IC50 of 23 nM.

S7941

NCT-501

NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with IC50 of 40 nM.

S2289

Daidzin

Daidzin is a natural organic compound in the class of phytochemicals known as isoflavones.

S7262

Vidofludimus

Vidofludimus is an orally active and potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 134 nM for human DHODH. Phase 2.

S2295

Emodin

Emodin is a purgative resin, 6-methyl-1,3,8-trihydroxyanthraquinone, from rhubarb, the buckthorn and Japanese Knotweed (Fallopia japonica).

S2296

Enoxolone

Enoxolone is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice.

S2302

Glycyrrhizin (Glycyrrhizic Acid)

Glycyrrhizin (Glycyrrhizic Acid) is a widely used anti-inflammatory agent isolated from the licorice root.

S2303

gossypol-Acetic acid

Gossypol Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.

S1717

Fomepizole

Fomepizoleは1種の競争性アルコール脱水素酵素(alcohol dehydrogenase)阻害剤です。この酵素はエチレングリコール(ethylene glycol)とメタノール(methanol)から有毒代謝物を変成する初階段を催化( catalyze)します。

S8206

AG-120

AG-120 (Ivosidenib)は1種、活性を持っている経口IDH1(isocitrate dehydrogenase type 1)阻害剤で、潜在的な抗腫瘍活性をしています。

S8205

AG-221 (Enasidenib)

Enasidenibは1種の新たで、有効的で、セレクティブで、可逆な経口IDH2変異酵素(mutant enzyme)の阻害剤です。

製品コード 製品説明 文献中の使用例 お客様のフィードバック
A5028

GAPDH Rabbit Recombinant mAb

Tags: Dehydrogenase inhibition | Dehydrogenase activity | Dehydrogenase assay | Dehydrogenase reaction | Dehydrogenase enzyme activity | pyruvate dehydrogenase inhibition | pyruvate dehydrogenase activity | pyruvate dehydrogenase assay | pyruvate dehydrogenase phosphorylation | pyruvate dehydrogenase cancer | pyruvate dehydrogenase pathway | pyruvate dehydrogenase activation | dihydropyrimidine dehydrogenase activity | stearoyl-CoA desaturase pathway | Dehydrogenase inhibitor review