NF-κB

信号経路図

研究分野

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S4902 QNZ (EVP4593) <1 mg/mL 5 mg/mL <1 mg/mL
S1848 Curcumin <1 mg/mL 73 mg/mL <1 mg/mL
S4073 Sodium 4-Aminosalicylate 42 mg/mL 42 mg/mL <1 mg/mL
S7351 JSH-23 <1 mg/mL 48 mg/mL 20 mg/mL
S7414 Caffeic Acid Phenethyl Ester <1 mg/mL 57 mg/mL 57 mg/mL
S8484 GSK2982772 <1 mg/mL 75 mg/mL 30 mg/mL
S8261 GSK583 <1 mg/mL 79 mg/mL 28 mg/mL
S3137 Sodium salicylate 32 mg/mL 32 mg/mL <1 mg/mL
S7672 Omaveloxolone (RTA-408) <1 mg/mL 100 mg/mL 20 mg/mL
S2261 Andrographolide <1 mg/mL 70 mg/mL <1 mg/mL
S2382 Evodiamine <1 mg/mL <1 mg/mL <1 mg/mL
S2313 Indole-3-carbinol 7 mg/mL 29 mg/mL 29 mg/mL
S7273 SC75741 <1 mg/mL 35 mg/mL <1 mg/mL
S2321 Magnolol <1 mg/mL 53 mg/mL 53 mg/mL
S2341 (-)-Parthenolide <1 mg/mL 49 mg/mL 49 mg/mL
S3604 Triptolide (PG490) <1 mg/mL 72 mg/mL <1 mg/mL
製品コード 製品説明 文献中の使用例 お客様のフィードバック
S4902

QNZ (EVP4593)

QNZ (EVP4593)はNF-κB活性化とTNF-α産出を有効に抑制して、Jurkat T細胞の中にIC50値が11 nMと7 nMに分かれます。

S1848

Curcumin

Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae).

S4073

Sodium 4-Aminosalicylate

Sodium 4-Aminosalicylate はNF-κBを通して結核を治療するのに用いられる抗生物質阻害と遊離基掃気です。

S7351

JSH-23

JSH-23は1種のNF-κB転写活性阻害剤です。RAW 264.7細胞系の中でのIC50値は7.1μMになります。

S7414

Caffeic Acid Phenethyl Ester

Caffeic Acid Phenethyl Esterは1種の有効的で、特異性のNF-κB活性化阻害剤で、抗酸化、免疫調節と抗炎の作用も表現できます。

S8484

GSK2982772

S8261

GSK583

S4712

Diethylmaleate

Diethylmaleateはマレイン酸のジェチルエステル(diethyl ester)形式で、Nrf2の活性剤です。Diethylmaleateはグルタチオンを消耗して、NFkBを抑制します。

S3137

Sodium salicylate

Sodium salicylate is used in medicine as an analgesic and antipyretic.

S7672

Omaveloxolone (RTA-408)

Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.

S2261

Andrographolide

Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.

S2382

Evodiamine

Evodiamine is an alkaloid extract from a plant known as Evodiae Fructus.

S2313

Indole-3-carbinol

Indole-3-carbinol is produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables.

S7273

SC75741

SC75741は1種の有効なNF-κB阻害剤です。EC50値は200 nMです。

S2321

Magnolol

Magnolol (2,2'-Bichavicol) is a bioactive compound found in the bark of the Houpu magnolia (Magnolia officinalis).

S2341

(-)-Parthenolide

(-)-Parthenolideは一種のセスキテルペンラクトン(sesquiterpene lactone)ですが、植物feverfew (Tanacetum parthenium)に存在して、MDM2のユビキチン化(ubiquitination)を促進して、p53細胞の功能を作動させます。

S3604

Triptolide (PG490)

Triptolide is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii.

製品コード 製品説明 文献中の使用例 お客様のフィードバック
S4902

QNZ (EVP4593)

QNZ (EVP4593)はNF-κB活性化とTNF-α産出を有効に抑制して、Jurkat T細胞の中にIC50値が11 nMと7 nMに分かれます。

S1848

Curcumin

Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae).

S4073

Sodium 4-Aminosalicylate

Sodium 4-Aminosalicylate はNF-κBを通して結核を治療するのに用いられる抗生物質阻害と遊離基掃気です。

S7351

JSH-23

JSH-23は1種のNF-κB転写活性阻害剤です。RAW 264.7細胞系の中でのIC50値は7.1μMになります。

S7414

Caffeic Acid Phenethyl Ester

Caffeic Acid Phenethyl Esterは1種の有効的で、特異性のNF-κB活性化阻害剤で、抗酸化、免疫調節と抗炎の作用も表現できます。

S8484

GSK2982772

S8261

GSK583

S4712

Diethylmaleate

Diethylmaleateはマレイン酸のジェチルエステル(diethyl ester)形式で、Nrf2の活性剤です。Diethylmaleateはグルタチオンを消耗して、NFkBを抑制します。

S3137

Sodium salicylate

Sodium salicylate is used in medicine as an analgesic and antipyretic.

S7672

Omaveloxolone (RTA-408)

Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.

S2261

Andrographolide

Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.

S2382

Evodiamine

Evodiamine is an alkaloid extract from a plant known as Evodiae Fructus.

S2313

Indole-3-carbinol

Indole-3-carbinol is produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables.

S7273

SC75741

SC75741は1種の有効なNF-κB阻害剤です。EC50値は200 nMです。

S2321

Magnolol

Magnolol (2,2'-Bichavicol) is a bioactive compound found in the bark of the Houpu magnolia (Magnolia officinalis).

S2341

(-)-Parthenolide

(-)-Parthenolideは一種のセスキテルペンラクトン(sesquiterpene lactone)ですが、植物feverfew (Tanacetum parthenium)に存在して、MDM2のユビキチン化(ubiquitination)を促進して、p53細胞の功能を作動させます。

S3604

Triptolide (PG490)

Triptolide is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii.