PDE

信号経路図

研究分野

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S2131 Roflumilast <1 mg/mL 81 mg/mL 15 mg/mL
S1431 Sildenafil Citrate <1 mg/mL 20 mg/mL <1 mg/mL
S1455 Cilomilast <1 mg/mL 69 mg/mL 50 mg/mL
S1512 Tadalafil <1 mg/mL 78 mg/mL <1 mg/mL
S2515 Vardenafil HCl Trihydrate 10 mg/mL 100 mg/mL 20 mg/mL
S8459 TAK-063 <1 mg/mL 85 mg/mL <1 mg/mL
S1550 Pimobendan <1 mg/mL 67 mg/mL 5 mg/mL
S2620 GSK256066 <1 mg/mL 5 mg/mL <1 mg/mL
S2687 PF-2545920 <1 mg/mL 78 mg/mL 78 mg/mL
S1430 Rolipram <1 mg/mL 55 mg/mL 55 mg/mL
S8034 Apremilast (CC-10004) <1 mg/mL 92 mg/mL <1 mg/mL
S1294 Cilostazol <1 mg/mL 74 mg/mL 6 mg/mL
S2484 Milrinone <1 mg/mL 42 mg/mL <1 mg/mL
S4019 Avanafil <1 mg/mL 97 mg/mL <1 mg/mL
S2127 S- (+)-Rolipram <1 mg/mL 55 mg/mL 55 mg/mL
S1673 Aminophylline 84 mg/mL 53 mg/mL <1 mg/mL
S3172 Anagrelide HCl <1 mg/mL 14 mg/mL <1 mg/mL
S1929 Irsogladine <1 mg/mL 2 mg/mL <1 mg/mL
S1504 Dyphylline 51 mg/mL 51 mg/mL <1 mg/mL
S1895 Dipyridamole <1 mg/mL 101 mg/mL 50 mg/mL
S4164 Doxofylline 24 mg/mL 53 mg/mL 2 mg/mL
S4090 Fenspiride HCl 59 mg/mL 9 mg/mL <1 mg/mL
S7224 Deltarasin <1 mg/mL 100 mg/mL 100 mg/mL
S2291 Diosgenin <1 mg/mL <1 mg/mL 83 mg/mL
S2312 Icariin <1 mg/mL 50 mg/mL <1 mg/mL
S4683 Sildenafil Mesylate 100 mg/mL 100 mg/mL 4 mg/mL
S4684 Sildenafil 14 mg/mL <1 mg/mL <1 mg/mL
S2320 Luteolin <1 mg/mL 57 mg/mL 3 mg/mL
S8218 PF-8380 <1 mg/mL 95 mg/mL <1 mg/mL
S2368 Theobromine <1 mg/mL <1 mg/mL <1 mg/mL

亜型選択性的な製品

製品コード 製品説明 文献中の使用例 お客様のフィードバック
S2131

Roflumilast

Roflumilast is a selective, long-acting the enzyme PDE-4 inhibitor with an IC50 of 0.8 nM.

S1431

Sildenafil Citrate

Sildenafil citrate is an agent used to treat erectile dysfunction and pulmonary arterial hypertension (PAH).

S1455

Cilomilast

Cilomilast は強力なLPDE4とHPDE4阻害剤で、IC50 がそれぞれ 100 nM と120 nMになる。

S1512

Tadalafil

Tadalafil is a PDE inhibitor.

S2515

Vardenafil HCl Trihydrate

Vardenafil HCl Trihydrate is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.

S8459

TAK-063

S1550

Pimobendan

Pimobendanは0.32のμMのIC50価値によるホスホジエステラーゼIII(PDE III)の選択的な阻害剤です。

S2620

GSK256066

GSK256066は、3.2pMのIC50による選択的なPED4B阻害剤です。

S2687

PF-2545920

PF-2545920は、有力で選択的なPDE10A</b> 阻害剤で、IC50 が 0.37 nMです。

S1430

Rolipram

Rolipram is a PDE4 inhibitor and an anti-inflammatory agent.

S8034

Apremilast (CC-10004)

Apremilast (CC-10004)は一種の経口生物有効なPDE4とTNF-α阻害剤で、IC50値が74 nMと77 nMです。

S1294

Cilostazol

Cilostazol is a medication used in the alleviation of the symptom of intermittent claudication in individuals with peripheral vascular disease.

S2484

Milrinone

Milrinone is a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 μM for the inhibition of FIII PDE.

S4019

Avanafil

Avanafilは、選択性の高いPDE5 の阻害剤で、IC50 が1 nMです。

S2127

S- (+)-Rolipram

s-(+)-Rolipramは、0.75のμMのIC50で、ヒト単球サイクリックAMPに特有のホスホジエステラーゼ(PDE4)を妨げます。

S1673

Aminophylline

Aminophylline is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist.

S3172

Anagrelide HCl

Anagrelide HCl is a drug used for the treatment of essential thrombocytosis.

S1504

Dyphylline

Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects.

S1895

Dipyridamole

Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.

S4164

Doxofylline

Doxofyllineは、ホスホジエステラーゼ阻害剤と喘息のキサンチン誘導体薬です。

S4090

Fenspiride HCl

Fenspiride is a bronchodilator with anti-inflammatory properties, inhibiting phosphodiesterase 4 and phosphodiesterase 3 activities with logIC50 values of 4.16 and 3.44, respectively, in human isolated bronchi.

S7224

Deltarasin

Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.

S2291

Diosgenin

Diosgenin is a steroid sapogenin and the precursor for the semisynthesis of progesterone which in turn was used in early combined oral contraceptive pills.

S2312

Icariin

Icariin is a flavonol and PDE5 inhibitor with IC50 of 1.0, 0.75, and 1.1 μM for PDE5A1, A2, and A3, respectively.

S4683

Sildenafil Mesylate

Sildenafil MesylateはSildenafilのメシル酸(mesylate)の形式です。SildenafilはPhosphodiesterase 5の阻害剤です。

S4684

Sildenafil

Sildenafilは1種のPhosphodiesterase 5の阻害剤です。このIC50値は5.22 nMです。

S2320

Luteolin

Luteolin is a non-selective PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively.

S8218

PF-8380

S2368

Theobromine

Theobromine is a xanthine alkaloid that is used as a bronchodilator and as a vasodilator.

製品コード 製品説明 文献中の使用例 お客様のフィードバック
S2131

Roflumilast

Roflumilast is a selective, long-acting the enzyme PDE-4 inhibitor with an IC50 of 0.8 nM.

S1431

Sildenafil Citrate

Sildenafil citrate is an agent used to treat erectile dysfunction and pulmonary arterial hypertension (PAH).

S1455

Cilomilast

Cilomilast は強力なLPDE4とHPDE4阻害剤で、IC50 がそれぞれ 100 nM と120 nMになる。

S1512

Tadalafil

Tadalafil is a PDE inhibitor.

S2515

Vardenafil HCl Trihydrate

Vardenafil HCl Trihydrate is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.

S8459

TAK-063

S1550

Pimobendan

Pimobendanは0.32のμMのIC50価値によるホスホジエステラーゼIII(PDE III)の選択的な阻害剤です。

S2620

GSK256066

GSK256066は、3.2pMのIC50による選択的なPED4B阻害剤です。

S2687

PF-2545920

PF-2545920は、有力で選択的なPDE10A</b> 阻害剤で、IC50 が 0.37 nMです。

S1430

Rolipram

Rolipram is a PDE4 inhibitor and an anti-inflammatory agent.

S8034

Apremilast (CC-10004)

Apremilast (CC-10004)は一種の経口生物有効なPDE4とTNF-α阻害剤で、IC50値が74 nMと77 nMです。

S1294

Cilostazol

Cilostazol is a medication used in the alleviation of the symptom of intermittent claudication in individuals with peripheral vascular disease.

S2484

Milrinone

Milrinone is a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 μM for the inhibition of FIII PDE.

S4019

Avanafil

Avanafilは、選択性の高いPDE5 の阻害剤で、IC50 が1 nMです。

S2127

S- (+)-Rolipram

s-(+)-Rolipramは、0.75のμMのIC50で、ヒト単球サイクリックAMPに特有のホスホジエステラーゼ(PDE4)を妨げます。

S1673

Aminophylline

Aminophylline is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist.

S3172

Anagrelide HCl

Anagrelide HCl is a drug used for the treatment of essential thrombocytosis.

S1504

Dyphylline

Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects.

S1895

Dipyridamole

Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.

S4164

Doxofylline

Doxofyllineは、ホスホジエステラーゼ阻害剤と喘息のキサンチン誘導体薬です。

S4090

Fenspiride HCl

Fenspiride is a bronchodilator with anti-inflammatory properties, inhibiting phosphodiesterase 4 and phosphodiesterase 3 activities with logIC50 values of 4.16 and 3.44, respectively, in human isolated bronchi.

S7224

Deltarasin

Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.

S2291

Diosgenin

Diosgenin is a steroid sapogenin and the precursor for the semisynthesis of progesterone which in turn was used in early combined oral contraceptive pills.

S2312

Icariin

Icariin is a flavonol and PDE5 inhibitor with IC50 of 1.0, 0.75, and 1.1 μM for PDE5A1, A2, and A3, respectively.

S4683

Sildenafil Mesylate

Sildenafil MesylateはSildenafilのメシル酸(mesylate)の形式です。SildenafilはPhosphodiesterase 5の阻害剤です。

S4684

Sildenafil

Sildenafilは1種のPhosphodiesterase 5の阻害剤です。このIC50値は5.22 nMです。

S2320

Luteolin

Luteolin is a non-selective PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively.

S8218

PF-8380

S2368

Theobromine

Theobromine is a xanthine alkaloid that is used as a bronchodilator and as a vasodilator.