Afatinib (BIBW2992)

製品コードS1011

Afatinib (BIBW2992)化学構造

分子量(MW):485.94

Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.

サイズ 価格(税別)  
JPY 39840.00
JPY 19920.00
JPY 34860.00
JPY 94620.00

文献中の使用例(37)

カスタマーフィードバック(4)

  • Cytoxicity of irreversible EGFR TKIS and ethacrynic acid on breast cells lines. A, Mean IC50 value of Afatinib.

    Oncotarget, 2016, 7(36):58038-58050. Afatinib (BIBW2992) purchased from Selleck.

    Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

  • Inhibition of anchorage-independent growth of lung tumor cell lines by selected inhibitors. Each selected cell line was treated with the indicated inhibitor at 0.1 μM and 1 μM concentrations for two weeks and cell colony size formation was scored under the Nikon inverted-phase microscope.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

    After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of BIBW2992 for 3h,followed by 15-minute stimolation of 100ng/ml EGF

    Dr. Zhang of Tianjin Medical University. Afatinib (BIBW2992) purchased from Selleck.

製品安全説明書

EGFR阻害剤の選択性比較

生物活性

製品説明 Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.
ターゲット
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 10 nM 14 nM
体外試験

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 NIPye45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLPcXBSUUN3ME2wMlAxPTd{IN88US=> M1TFbXNCVkeHUh?=
KASUMI-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwMEC5NVEh|ryP MX;TRW5ITVJ?
HCC2218 NEPZcIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwMEC5PFch|ryP M1TwcnNCVkeHUh?=
KARPAS-45 M1zaW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37ufGlEPTB;MD6wNVY4OSEQvF2= MmTEV2FPT0WU
HSC-4 M3roN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\CSpBKSzVyPUCuNFE4PDhizszN MWjTRW5ITVJ?
CHL-1 NEHSN2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrkOIRKSzVyPUCuNFE5OzlizszN MUjTRW5ITVJ?
KY821 NWDh[2U1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFL0So5KSzVyPUCuNFIxPiEQvF2= MnrxV2FPT0WU
NCI-N87 M4fxR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjqeHFKSzVyPUCuNFI4PzNizszN NUS0bVRwW0GQR1XS
DOK MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjHb4RbUUN3ME2wMlA{OTl2IN88US=> MUDTRW5ITVJ?
DSH1 NG\XTYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4C5[2lEPTB;MD6wN|MyPCEQvF2= MXnTRW5ITVJ?
MDA-MB-175-VII NIHwSnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvyfoVtUUN3ME2wMlA{PDF4IN88US=> M{f4eHNCVkeHUh?=
NCI-H2170 M{\jU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33V[GlEPTB;MD6wN|czQCEQvF2= NGfrZllUSU6JRWK=
BT-474 M4\vXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPu[WNKSzVyPUCuNFQ6QDZizszN M2LlTnNCVkeHUh?=
EFO-27 NGXNRlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYSzTWFWUUN3ME2wMlA2OTh{IN88US=> NYnhRnRbW0GQR1XS
NCI-H720 M3WxcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fCSWlEPTB;MD6wOVMzPSEQvF2= MmL2V2FPT0WU
PC-14 NIq2RnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLVPJNKSzVyPUCuNFU3PjhizszN NI\DXnZUSU6JRWK=
EC-GI-10 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHFd3Q5UUN3ME2wMlA2QTF{IN88US=> NWezbFZIW0GQR1XS
KYSE-450 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHXTWM2OD1yLkC1PVc5KM7:TR?= M3fFPHNCVkeHUh?=
BPH-1 NF\HUlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMEW5PFgh|ryP M1Kx[3NCVkeHUh?=
NCI-H292 Mm\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;yWGlEPTB;MD6wOlA6KM7:TR?= NHf2eXhUSU6JRWK=
H9 M2CxWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrBO3R4UUN3ME2wMlA4OTN{IN88US=> M{HuOXNCVkeHUh?=
NCI-H526 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPtTlJKSzVyPUCuNFc5OjNizszN MlWwV2FPT0WU
NCI-H1623 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVr3TYRSUUN3ME2wMlA5ODJ3IN88US=> Mn7UV2FPT0WU
KYSE-140 NFPQclFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVG5fIhMUUN3ME2wMlA5OzNizszN NV\BSVAxW0GQR1XS
Ca9-22 Mn[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1S1bmlEPTB;MD6wPFM2OyEQvF2= NGLSUnNUSU6JRWK=
AU565 MlHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vkS2lEPTB;MD6wPFUxPCEQvF2= Mo\uV2FPT0WU
ZR-75-30 NIHpVlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXKT2kyUUN3ME2wMlA6PTR3IN88US=> MoPjV2FPT0WU
NCI-H1770 M{XjS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELkVHFKSzVyPUCuNVAzQCEQvF2= M4DrdHNCVkeHUh?=
LB2241-RCC M{TpUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXNcmFKSzVyPUCuNVA5QDRizszN NGn0d2NUSU6JRWK=
CAL-39 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LxN2lEPTB;MD6xNVc6OiEQvF2= M4n5[HNCVkeHUh?=
UACC-893 NXTPRnZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlyxTWM2OD1yLkGxPFg2KM7:TR?= MoLCV2FPT0WU
LU-65 Mmi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTaTWM2OD1yLkGyOlM{KM7:TR?= MkfhV2FPT0WU
HN MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HmbGlEPTB;MD6xN|A4PyEQvF2= NUToe4NlW0GQR1XS
TI-73 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\4VGY6UUN3ME2wMlE1PzF3IN88US=> NYDzPFIxW0GQR1XS
KU812 M{DoVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwMUW0OVYh|ryP NF;WSllUSU6JRWK=
SW13 NFrvT2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33DV2lEPTB;MD6xOlIyPiEQvF2= MlG2V2FPT0WU
BB30-HNC M2\hOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPwW4RKSzVyPUCuNVY2PzZizszN Ml7MV2FPT0WU
HSC-2 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorTTWM2OD1yLkG2PFM4KM7:TR?= NF7sdnFUSU6JRWK=
BV-173 M{nrS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHDelB{UUN3ME2wMlE4PTl4IN88US=> MYLTRW5ITVJ?
CAL-27 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDtWolKSzVyPUCuNVc3OzZizszN MULTRW5ITVJ?
SBC-1 MlnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPT[|FLUUN3ME2wMlE5QTV7IN88US=> NVXudo8zW0GQR1XS
CAL-33 MnHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LTcmlEPTB;MD6yNFE5PCEQvF2= NXLQVHJsW0GQR1XS
NCI-H209 NF3EZVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLVU|U6UUN3ME2wMlIxPDZizszN NUf0T29jW0GQR1XS
COR-L105 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMkGwPFQh|ryP NVzKS49TW0GQR1XS
HSC-3 M3;xfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3JeZJKSzVyPUCuNlEyQThizszN MoPlV2FPT0WU
NCI-H69 NFKyTWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwMkG0OVEh|ryP NEX6UmtUSU6JRWK=
MOLT-13 NFOzeotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXlc|lKSzVyPUCuNlM6PzVizszN Mmq2V2FPT0WU
ML-2 NV2xdlhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;sbXdIUUN3ME2wMlI1QDB{IN88US=> NUHGNJEzW0GQR1XS
IGROV-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnORmFlUUN3ME2wMlI2QTV{IN88US=> NHu1N2xUSU6JRWK=
TK10 NUHMbG1DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfFTWM2OD1yLkK2O|M5KM7:TR?= NEK4W3dUSU6JRWK=
EoL-1-cell MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMk[4PVIh|ryP M3TUU3NCVkeHUh?=
HO-1-N-1 NWjveWJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYO5TYtqUUN3ME2wMlI4QDV|IN88US=> NWT2cHljW0GQR1XS
BHY MnP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XrZ2lEPTB;MD6yPFY2PSEQvF2= MUfTRW5ITVJ?
LU-139 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwM{C1NUDPxE1? M3;FSnNCVkeHUh?=
23132-87 NWPV[4JUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\OTo1tUUN3ME2wMlMyQTJ|IN88US=> NX2w[Hl1W0GQR1XS
ACHN MornS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfKOWJKSzVyPUCuN|E6QTRizszN MnPxV2FPT0WU
DoTc2-4510 M3LsSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXhUYJPUUN3ME2wMlMzOjF7IN88US=> MlP2V2FPT0WU
BB65-RCC MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;ZSGlEPTB;MD6zOFU6OyEQvF2= MVvTRW5ITVJ?
HLE MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7NW3JKSzVyPUCuN|UxPDZizszN MWnTRW5ITVJ?
HCC1419 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYX3R|NVUUN3ME2wMlM3PDB6IN88US=> NGjVVmxUSU6JRWK=
A388 NV7wNXk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjrUolqUUN3ME2wMlM3QDV5IN88US=> MVrTRW5ITVJ?
NUGC-3 NWfpV5ZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1q4UGlEPTB;MD6zPFM4OyEQvF2= MYrTRW5ITVJ?
KYSE-180 NXXXUJlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwM{mwPFkh|ryP NVHS[W5SW0GQR1XS
TE-6 M4Lqd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwNECyOFYh|ryP MnzEV2FPT0WU
A498 MkfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\0cndwUUN3ME2wMlQxPjd2IN88US=> NF3ORlJUSU6JRWK=
NCI-H1648 NUDiTW06T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml:2TWM2OD1yLkS0NVgzKM7:TR?= NGL6OJpUSU6JRWK=
DU-145 NGX0UohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml21TWM2OD1yLkS0PFM{KM7:TR?= MlXqV2FPT0WU
CW-2 NGrFcItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwNE[5NVQh|ryP M1zUUnNCVkeHUh?=
A431 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwNEiyN|Mh|ryP MXzTRW5ITVJ?
SAS NXzLd|QzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nBTmlEPTB;MD60PFM6QCEQvF2= MkXZV2FPT0WU
NCI-H2126 NXG2OZhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1Ttc2lEPTB;MD61NVkzPiEQvF2= M2fpeXNCVkeHUh?=
NCI-H358 M2HvOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37CXGlEPTB;MD61N|IyKM7:TR?= MkfGV2FPT0WU
FADU Mm\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nGbGlEPTB;MD61OFQxPCEQvF2= NW\jPHlbW0GQR1XS
ACN M1;TUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrrOpp[UUN3ME2wMlU2ODl2IN88US=> NH;FOXdUSU6JRWK=
HCC70 M1vEOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXz6eYxGUUN3ME2wMlU4PjZzIN88US=> M3;PN3NCVkeHUh?=
NCI-H1838 MmH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHVcmp1UUN3ME2wMlYxOjl7IN88US=> MVLTRW5ITVJ?
CAL-54 M2j1b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{e4WWlEPTB;MD62NVYzOSEQvF2= NXfKU5FUW0GQR1XS
NCI-H1975 MlKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPHWWZKSzVyPUCuOlE4OjhizszN MWrTRW5ITVJ?
COR-L88 MmPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV2xe5h[UUN3ME2wMlY1OTF|IN88US=> NG[xWmVUSU6JRWK=
CTV-1 NXXtS217T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkP3TWM2OD1yLk[0N|kzKM7:TR?= NHThb4xUSU6JRWK=
EW-18 Mk\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoroTWM2OD1yLk[4Olk5KM7:TR?= NFSwXG1USU6JRWK=
HCC1806 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvobHhKSzVyPUCuOlk3PjZizszN M{fKcXNCVkeHUh?=
HuP-T4 M1XFb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3xTWM2OD1yLk[5O|Yh|ryP NUHPS2U6W0GQR1XS
MDA-MB-361 MkWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2KyWGlEPTB;MD63NlY3OiEQvF2= MXTTRW5ITVJ?
NCI-H1573 NGfwTXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HpUmlEPTB;MD63N|Y{KM7:TR?= M{HGOnNCVkeHUh?=
KU-19-19 M3TNbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzYboJKSzVyPUCuO|c1PjRizszN MXrTRW5ITVJ?
COLO-678 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUH1VYV3UUN3ME2wMlgxQDN2IN88US=> MmDkV2FPT0WU
C-33-A MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DP[mlEPTB;MD64NVI6PyEQvF2= MnHFV2FPT0WU
Calu-3 NXLz[YEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17QWGlEPTB;MD64NVQ{PCEQvF2= MYnTRW5ITVJ?
AGS MnPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwOEO2OFgh|ryP MkTyV2FPT0WU
SCC-25 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2X6[GlEPTB;MD64OFE4OSEQvF2= NY[xc4FJW0GQR1XS
JVM-2 NFTjVGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjSTWM2OD1yLki4Nlk6KM7:TR?= NV;1dmlTW0GQR1XS
HCE-T NELLZZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDLUo5KSzVyPUCuPFg1OjhizszN MW\TRW5ITVJ?
ES4 M1ziV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHS5S4tKSzVyPUCuPVc5OzZizszN MlrEV2FPT0WU
EKVX M13oUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzETWM2OD1zLkCxNFY1KM7:TR?= MlHzV2FPT0WU
D-542MG NH7BSFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPoXm1rUUN3ME2xMlAyODZ2IN88US=> NHe4enVUSU6JRWK=
SW1116 NX\vfG1ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmi4TWM2OD1zLkCxNlg4KM7:TR?= NH7iVZlUSU6JRWK=
5637 M17RO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrR[phKSzVyPUGuNFE2OSEQvF2= NFL6fZpUSU6JRWK=
HT-1376 NYLjdIFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTFwMEG1NVMh|ryP MlzIV2FPT0WU
NB69 M2m4VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrBbopKSzVyPUGuNFI6PDVizszN NU\5PHV6W0GQR1XS
YKG-1 NEOzcZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXflTYpxUUN3ME2xMlA2PDF7IN88US=> M3rwcnNCVkeHUh?=
EW-3 M4PJS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTFwMEe4PFMh|ryP MnzFV2FPT0WU
GCIY NWfaUmJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XUSGlEPTB;MT6wPFExPCEQvF2= NVTMWGxHW0GQR1XS
SK-MES-1 MnHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XjbWlEPTB;MT6xNVQ5PyEQvF2= M{fKc3NCVkeHUh?=
PANC-08-13 MkLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\JTWM2OD1zLkG2OFE3KM7:TR?= NXz1RWlzW0GQR1XS
SK-NEP-1 MkDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXvcWxZUUN3ME2xMlE4PTF|IN88US=> MmLIV2FPT0WU
SW954 NGHsRo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LJW2lEPTB;MT6yNFIyPCEQvF2= Ml7NV2FPT0WU
NCI-SNU-5 NFnKb21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jVZ2lEPTB;MT6yN|kh|ryP NXPk[2tpW0GQR1XS
SW48 NHrU[2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUm2XIQ2UUN3ME2xMlI2PDN{IN88US=> NVPPNXY4W0GQR1XS
HT-3 NHWyUWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DOSGlEPTB;MT6yPFc2OyEQvF2= NYrUZnpPW0GQR1XS
ETK-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;0TWM2OD1zLkO3OFU3KM7:TR?= MXnTRW5ITVJ?
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NCI-H727 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXrT3RKSzVyPUiuNVA1OiEQvF2= NYH2WpE3W0GQR1XS
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NCI-H1993 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPw[ot1UUN3ME24MlM{PjNzIN88US=> M1;renNCVkeHUh?=
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HCE-4 MnnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTlwMkG1OVgh|ryP NGTib|RUSU6JRWK=
BALL-1 M1PrNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTEbJd{UUN3ME25MlIyQTB5IN88US=> M3f4[XNCVkeHUh?=
SF539 MlvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jLO2lEPTB;OT6yN|U3OiEQvF2= MXTTRW5ITVJ?
CAMA-1 NHvnfVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELlR2tKSzVyPUmuNlgyOjhizszN Ml73V2FPT0WU
C32 MlTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvBXpo5UUN3ME25MlM{ODZ2IN88US=> Mnn0V2FPT0WU
NCI-H1703 M4TScWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1K3emlEPTB;OT6zOFM4PSEQvF2= NIfRVFNUSU6JRWK=
NCI-H1650 Ml3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jSRmlEPTB;OT62NFk1PiEQvF2= MlzjV2FPT0WU
NCI-H1563 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\vTWM2OD17Lke2NFMyKM7:TR?= M2OzOnNCVkeHUh?=
CAL-85-1 Mom1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\MSmlEPTB;OT64O|M5OyEQvF2= NVOw[mhjW0GQR1XS
UM-UC-3 NHr0dZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\HVJNKSzVyPUmuPVUxOyEQvF2= M{X1TXNCVkeHUh?=
BxPC-3 Mn3nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTFyLkC5O|Ih|ryP NF;tcIdUSU6JRWK=
MHH-PREB-1 MnPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Kxe2lEPTB;MUCuNVk6QSEQvF2= MWnTRW5ITVJ?
DEL MmSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDrPVRKSzVyPUGwMlM6PDZizszN MXPTRW5ITVJ?
HuCCT1 MlzKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2iycWlEPTB;MUCuOlA{OyEQvF2= NY[4cpNLW0GQR1XS
OVCAR-4 NG\iXXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrlZZZNUUN3ME2xNE45QDN3IN88US=> NUPGdVdyW0GQR1XS
CAL-72 NHTldmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrzcHBKSzVyPUGwMlk{QTFizszN MoDmV2FPT0WU
HCC1954 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDDTWM2OD1zMT6wO|U1KM7:TR?= MmG1V2FPT0WU
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FTC-133 MkDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXq4d4hlUUN3ME2xNU4yPDB5IN88US=> NFPObnZUSU6JRWK=
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T84 M4HIe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVv2b3BFUUN3ME2xNU4{QTB5IN88US=> MUnTRW5ITVJ?
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MC-IXC MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTFzLk[3Nlgh|ryP NETnWYhUSU6JRWK=
HOP-62 NVHMcolpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTFzLk[3OlQh|ryP NEmxUJhUSU6JRWK=
NOS-1 MmHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3GRlNKSzVyPUGxMlcyODlizszN NHniW5dUSU6JRWK=
SW1573 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjZR3FvUUN3ME2xNU44Ojl3IN88US=> M2XOb3NCVkeHUh?=
WM-115 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTHW2NKSzVyPUGxMlc2QDhizszN M{PZUXNCVkeHUh?=
HuO9 M3uzdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTFzLki3O|Qh|ryP M2rEU3NCVkeHUh?=
YAPC NYfr[W5jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjCOIVVUUN3ME2xNU46OjV7IN88US=> MYDTRW5ITVJ?
MDA-MB-453 MmmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TnPGlEPTB;MUGuPVUyPSEQvF2= MUfTRW5ITVJ?
NCI-H596 NY\QblB[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnyc3ZKSzVyPUGyMlA{PjlizszN MWfTRW5ITVJ?
A172 NHfG[VFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HSeWlEPTB;MUKuNFc6QCEQvF2= MV3TRW5ITVJ?
RS4-11 M3rUZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnzSoNuUUN3ME2xNk4yPzJ3IN88US=> NHjUT4VUSU6JRWK=
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SW837 M2nrZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2KyXWlEPTB;MUKuPVAzQCEQvF2= NFi2TXlUSU6JRWK=
NMC-G1 MlLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTSOnJKSzVyPUGyMlkzOzRizszN MoLnV2FPT0WU
PFSK-1 MmT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPGcJdKSzVyPUGzMlA3KM7:TR?= NVXYcmlsW0GQR1XS
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SK-UT-1 NGHqV|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfaNotKSzVyPUGzMlExQDNizszN NF7qfnBUSU6JRWK=
OVCAR-5 NGewUplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTF|LkG1PVMh|ryP MVrTRW5ITVJ?
8505C NYGzTJZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rwPWlEPTB;MUOuNlA3PyEQvF2= NETwSVJUSU6JRWK=
SK-MEL-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTF|LkexN|Uh|ryP MYXTRW5ITVJ?
LK-2 NXPSZ|diT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fWbmlEPTB;MUOuO|Y{QSEQvF2= MkO5V2FPT0WU
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NCI-H1793 M2jPZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnpWo5IUUN3ME2xOE4zODh5IN88US=> Mor0V2FPT0WU
BHT-101 NIfLVIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHXb3hKSzVyPUG0MlI1OSEQvF2= NWHobHVjW0GQR1XS
RKO MkfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTF2LkWwO|Uh|ryP M1PtbXNCVkeHUh?=
NEC8 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXyVmZLUUN3ME2xOE42PDd{IN88US=> NXn1VHVLW0GQR1XS
PANC-10-05 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfnTWM2OD1zND62NlQ4KM7:TR?= M{iyT3NCVkeHUh?=
NCI-H2030 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUT5b2VyUUN3ME2xOE43PDR6IN88US=> M2K5W3NCVkeHUh?=
C2BBe1 MkjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37XTGlEPTB;MUSuO|Y1KM7:TR?= MnezV2FPT0WU
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HCC1395 M{j3WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTF2LkmzN|gh|ryP NFP3RoVUSU6JRWK=
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SW1463 NUjtXHN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TNWGlEPTB;MUWuNFQ5PSEQvF2= M1TNT3NCVkeHUh?=
J82 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTF3LkC1O{DPxE1? M3jOb3NCVkeHUh?=
CAL-120 MlXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zVU2lEPTB;MUWuNVQ1PyEQvF2= NXW0Zm4xW0GQR1XS
COLO-824 NF;DcotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7TNI1FUUN3ME2xOU4yPTd7IN88US=> NEC4U41USU6JRWK=
LNCaP-Clone-FGC MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TGcmlEPTB;MUWuOFI1QCEQvF2= NVXpTmV6W0GQR1XS
CP66-MEL NWGyc4R1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfwTWM2OD1zNT60Olg5KM7:TR?= MVjTRW5ITVJ?
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OVCAR-8 M4PTbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofxTWM2OD1zNT64PFYyKM7:TR?= M1qzXHNCVkeHUh?=
MFE-280 NXjlR5kzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPETWM2OD1zNj6wOFg5KM7:TR?= NFe2SpFUSU6JRWK=
MHH-NB-11 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLpT4NoUUN3ME2xOk4xQDN7IN88US=> M{nzTHNCVkeHUh?=
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HuP-T3 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTF4Lk[1O|Yh|ryP MmHXV2FPT0WU
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NCI-H1092 M1zPNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInOZ|lKSzVyPUG2Mlg{OTZizszN MUDTRW5ITVJ?
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ES3 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzs[2FnUUN3ME2xOk46OTN2IN88US=> M3jhVnNCVkeHUh?=
COLO-684 Mn;wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTrTWM2OD1zNj65OFc4KM7:TR?= NXLxfZJxW0GQR1XS
NCI-H661 NEH6XnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TaVWlEPTB;MU[uPVY6PCEQvF2= NEjMN4ZUSU6JRWK=
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NCI-H2405 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrvTWM2OD1zNz6xPVc1KM7:TR?= MVfTRW5ITVJ?
U-2-OS NUOyb3FWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jRNWlEPTB;MUeuOVMxPyEQvF2= M{PDenNCVkeHUh?=
RERF-LC-MS Mln1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;TTWM2OD1zNz61OVA5KM7:TR?= MWjTRW5ITVJ?
NCI-H2342 NIXxdnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\iTWM2OD1zNz61OVch|ryP M{jMdXNCVkeHUh?=
ES8 M{DUNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHaTWM2OD1zNz62NFg4KM7:TR?= NF3BVIpUSU6JRWK=
MOLT-16 NIrj[ZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrkTWM2OD1zNz64PVM1KM7:TR?= MVPTRW5ITVJ?
RH-18 NWDHbXBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEj4XJBKSzVyPUG4MlAxOzVizszN MW\TRW5ITVJ?
D-283MED NG\Seo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;YPGw5UUN3ME2xPE4xODh6IN88US=> NWXzN3JGW0GQR1XS
RCC10RGB NW\BU|RYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTF6LkC1OVkh|ryP NV;GW4FDW0GQR1XS
NCI-H1437 NGPLdIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPjU5BrUUN3ME2xPE4yPjRzIN88US=> NV7zTVdrW0GQR1XS
SW982 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nnVWlEPTB;MUiuNlY4OSEQvF2= MoLDV2FPT0WU
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A704 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jLTWlEPTB;MUiuOFc2OyEQvF2= MV3TRW5ITVJ?
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SCH MmjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvIdmpKSzVyPUG4MlY1PTZizszN MkntV2FPT0WU
COLO-320-HSR M1PUd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3weVZKSzVyPUG4Mlc1PiEQvF2= NW\FdoxuW0GQR1XS
Mo-T MmPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXPTndiUUN3ME2xPE45OjB2IN88US=> NUfJSWJiW0GQR1XS
Saos-2 NWHzWJRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX73XWZNUUN3ME2xPU4yOTZ{IN88US=> M4q1T3NCVkeHUh?=
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KYSE-510 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXYNGJUUUN3ME2xPU45PzR6IN88US=> M37PWHNCVkeHUh?=
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GCT NXXrT4ZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\5TIpQUUN3ME2yNE4{ODJ4IN88US=> MUPTRW5ITVJ?
KARPAS-299 M1XDWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTJyLkO0NlIh|ryP MljhV2FPT0WU
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NCI-H1395 NVLBZWYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlv3TWM2OD1{MD62Olk4KM7:TR?= NXfMcpMzW0GQR1XS
HCC1187 Ml3YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7hepl1UUN3ME2yNE43PzN2IN88US=> NULpV45HW0GQR1XS
Becker MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTJyLkeyNFEh|ryP NEfSTplUSU6JRWK=
LU-134-A MkLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTJzLkGwNlYh|ryP NF\3cHFUSU6JRWK=
MKN45 MknGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3ic45OUUN3ME2yNU4yPTVzIN88US=> NVW2RVRmW0GQR1XS
LC-2-ad MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWn5UHp4UUN3ME2yNU4zPzJ7IN88US=> M2PTSXNCVkeHUh?=
EW-24 MoTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTNTWM2OD1{MT6zPVQ2KM7:TR?= MWTTRW5ITVJ?
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NCI-H2052 MljCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTJzLki5OlMh|ryP MVfTRW5ITVJ?
A4-Fuk MoDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fSdmlEPTB;MkKuNVQyQSEQvF2= MlPaV2FPT0WU
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CHP-212 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PsSmlEPTB;MkKuN|IzOiEQvF2= NV\Ld5FQW0GQR1XS
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MPP-89 M1WxPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXG5eZJtUUN3ME2yNk45PjZzIN88US=> NEDqfWhUSU6JRWK=
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COLO-792 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XQSmlEPTB;MkWuNlc{OiEQvF2= MnTVV2FPT0WU
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RPMI-8866 NFzCOWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHjTWM2OD1{Nz63OVYzKM7:TR?= MVPTRW5ITVJ?
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D-566MG M4L6R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jObWlEPTB;MkmuPVM6OyEQvF2= MWrTRW5ITVJ?
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D-336MG NICxWIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHqWodrUUN3ME2zNE4zQDl{IN88US=> MUfTRW5ITVJ?
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DK-MG MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnKVIxHUUN3ME2zNE42PDV4IN88US=> M1O3PHNCVkeHUh?=
SK-HEP-1 NY\Wb3pZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3j5fmlEPTB;M{CuOlMzPiEQvF2= Mn\JV2FPT0WU
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NCI-H510A M2X4b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTNzLkSwNFYh|ryP Ml21V2FPT0WU
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22RV1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzUTFlKSzVyPUO0MlE4PTRizszN NV;CRZVQW0GQR1XS
KM-H2 M3zze2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HkSWlEPTB;M{SuNVc4QSEQvF2= NHPQcmZUSU6JRWK=
NCI-H2122 M{n2XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jmOmlEPTB;M{SuN|Q4OSEQvF2= NEGwPGNUSU6JRWK=
ABC-1 MoW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjad29KSzVyPUO0MlM3QTNizszN NVX4b4JbW0GQR1XS
NCI-H1355 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rTT2lEPTB;M{SuN|g5QSEQvF2= MmS5V2FPT0WU
NOMO-1 NXLtVXJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoKwTWM2OD1|ND61O|A{KM7:TR?= M2DFT3NCVkeHUh?=
MZ7-mel MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13r[mlEPTB;M{SuOlQ5PyEQvF2= MV7TRW5ITVJ?
NCI-H810 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3BTWM2OD1|ND63Nlc5KM7:TR?= Mln3V2FPT0WU
D-392MG NHjScFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlq4TWM2OD1|NT6wOVY2KM7:TR?= M4nUUXNCVkeHUh?=
LB771-HNC NGLxR45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHqTWM2OD1|NT6xOlU5KM7:TR?= M3;1[nNCVkeHUh?=
COLO-679 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGr1cW9KSzVyPUO1MlM5QCEQvF2= NHrmXJBUSU6JRWK=
SK-PN-DW Mm\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rxdWlEPTB;M{WuOFM3QSEQvF2= NYX2UVVTW0GQR1XS
VA-ES-BJ M4rJcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrEb2NjUUN3ME2zOU41PjR7IN88US=> NIm5RVVUSU6JRWK=
KNS-42 Mk\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTN3LkW4NlYh|ryP MVHTRW5ITVJ?
RVH-421 NH;BXI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnUXXFEUUN3ME2zOU44PjR3IN88US=> M{PBeHNCVkeHUh?=
P30-OHK MkLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3YOIhKSzVyPUO1Mlg4PTJizszN MWfTRW5ITVJ?
G-402 NHHzflFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljuTWM2OD1|NT65PFY4KM7:TR?= M13LPXNCVkeHUh?=
S-117 M2DI[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYe3OWtMUUN3ME2zOk4{ODB6IN88US=> MWrTRW5ITVJ?
RXF393 M37GRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLEfodMUUN3ME2zOk4{Pzh3IN88US=> MULTRW5ITVJ?
LCLC-103H M3m5c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTN4Lke4NFMh|ryP MlruV2FPT0WU
U-118-MG MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTN4Lki4OFch|ryP MkT1V2FPT0WU
8-MG-BA NGr2ZoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLQTWM2OD1|Nj65OFg{KM7:TR?= NWS3NJU6W0GQR1XS
MFH-ino MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\tPGlEPTB;M{euN|M4OSEQvF2= MoTJV2FPT0WU
NCI-H23 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzsTWM2OD1|Nz60NVk3KM7:TR?= M4TpN3NCVkeHUh?=
NCI-H446 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTN5LkS4OlIh|ryP MVnTRW5ITVJ?
LU-99A NHPm[YhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorQTWM2OD1|Nz61O|MyKM7:TR?= Mn;TV2FPT0WU
KP-N-YN MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{W3OGlEPTB;M{euOlE6PSEQvF2= Mo\MV2FPT0WU
SCC-9 M{ewfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrqNo1KSzVyPUO3Mlc5OzhizszN M1XNTXNCVkeHUh?=
EFM-19 NYXhNoY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfPfmVKSzVyPUO3Mlc6PjdizszN MmS4V2FPT0WU
A427 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml76TWM2OD1|Nz65NVA4KM7:TR?= MYTTRW5ITVJ?
LB831-BLC NH;mfGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPyTWM2OD1|OD62NFM6KM7:TR?= NGHDb4lUSU6JRWK=
HOS M13DV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13jOGlEPTB;M{muOlI4OyEQvF2= NWXscY1qW0GQR1XS
LAN-6 NXXKUJFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLlTWM2OD12MD6wNVEzKM7:TR?= NYLKeFl[W0GQR1XS
U251 NF7oSVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTRyLkSwOVQh|ryP MnP6V2FPT0WU
SNU-387 M1fINWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXTTWM2OD12MD60OVU{KM7:TR?= NWX2OG9xW0GQR1XS
DMS-79 M3z4Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fDOGlEPTB;NECuOVg5QSEQvF2= NG\ZbIVUSU6JRWK=
SK-LU-1 M33VeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTRyLk[1Olgh|ryP NXXSTGdvW0GQR1XS
HT NVPEe3JHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTRyLk[2N|kh|ryP M16wVnNCVkeHUh?=
KP-N-YS NU\KWHhDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\SOppKSzVyPUSwMlY4PjhizszN NX;Pe|cyW0GQR1XS
DMS-114 Mn\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XmemlEPTB;NECuPFM4PCEQvF2= MUPTRW5ITVJ?
HUTU-80 MorHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTRzLkC1Olkh|ryP M33XPHNCVkeHUh?=
ONS-76 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nGU2lEPTB;NEGuOFcxQSEQvF2= MUfTRW5ITVJ?
A673 NHLSXphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfidnBPUUN3ME20NU42OTV5IN88US=> MYXTRW5ITVJ?
HPAF-II M1HUd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXHRphKSzVyPUSxMlY4ODlizszN NHr3[Y1USU6JRWK=
UACC-257 MlPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mme0TWM2OD12MT63N|Y6KM7:TR?= NVi0[25lW0GQR1XS
EW-22 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3qTWM2OD12MT64Olk4KM7:TR?= NFHaSGVUSU6JRWK=
NCI-H1755 M{ezT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TZOWlEPTB;NEGuPFczPSEQvF2= M2TZNHNCVkeHUh?=
KYSE-150 M1;Je2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHDVXVKSzVyPUSyMlE4QDJizszN M37ibnNCVkeHUh?=
CGTH-W-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnztTWM2OD12Mj60PVU2KM7:TR?= MWPTRW5ITVJ?
NB13 M3zwXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIGwOldKSzVyPUSyMlYzOTdizszN NFWxOZVUSU6JRWK=
SW872 NEjIRmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rYe2lEPTB;NEKuOlM{OSEQvF2= Mlz1V2FPT0WU
KP-4 NEnEe5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHJPFZKSzVyPUSyMlg5OzJizszN NFXMXo1USU6JRWK=
HCC38 M2n4cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTR{Lkm2NVgh|ryP MXXTRW5ITVJ?
BB49-HNC NHvYNFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjVTWM2OD12Mz6yN|U3KM7:TR?= M2DofXNCVkeHUh?=
CAL-62 M4nLbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXyTWM2OD12Mz60NFI5KM7:TR?= M{jWOXNCVkeHUh?=
NCI-H2029 NUjQTHZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnaTWM2OD12Mz61OVgyKM7:TR?= MkTXV2FPT0WU
M14 NWXoXFdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnBTWM2OD12ND6xN|MzKM7:TR?= NUnObYdWW0GQR1XS
COLO-680N MmLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nheGlEPTB;NESuN|M6KM7:TR?= NUe4R2lCW0GQR1XS
Hs-578-T NETMPYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTR3LkCyPVQh|ryP M{XvU3NCVkeHUh?=
MSTO-211H NIfOTWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFO3VZFKSzVyPUS1Mlk1QDJizszN M3rUdnNCVkeHUh?=
EW-1 M3HyOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFuz[o5KSzVyPUS1Mlk3QDlizszN NX;jT3l6W0GQR1XS
SW948 MmXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mny5TWM2OD12Nj60OFYzKM7:TR?= NUTy[Yd4W0GQR1XS
NCI-H460 NU\XfZJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYS1dVZCUUN3ME20Ok42OjNizszN NVvkPYZqW0GQR1XS
CAS-1 NYnTcIp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTR4Lke3NFEh|ryP NXnmOVBsW0GQR1XS
TGBC11TKB MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfIc3pKSzVyPUS3MlE4PzdizszN M4WyVHNCVkeHUh?=
HD-MY-Z MknPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUWyNXZEUUN3ME20PE44QDZizszN M2\YfHNCVkeHUh?=
NCI-H226 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\BTWM2OD12OT63O|g2KM7:TR?= NWPEUlBZW0GQR1XS
PA-1 NFTLbYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlOwTWM2OD12OT64N|M2KM7:TR?= MVfTRW5ITVJ?
LB2518-MEL MoLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrmTVRYUUN3ME20PU45PzJ|IN88US=> NX[3Z3FJW0GQR1XS
A101D NYewNVh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljOTWM2OD12OT65OFI2KM7:TR?= M1frWnNCVkeHUh?=
NCI-H2087 NFnac45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\2UplKSzVyPUS5Mlk3QDJizszN NIjSZYdUSU6JRWK=

多くの細胞株試験データを見る場合、クリックしてください

体内試験 Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

お薦めの試験操作(参考用のみ)

キナーゼ試験:

[1]

+ 展開

In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
細胞試験:

[1]

+ 展開
  • 細胞株: NSCLC cells
  • 濃度: 0-10 μM
  • 反応時間: 1 hour
  • 実験の流れ:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (参考用のみ)
動物試験:

[1]

+ 展開
  • 動物モデル: Athymic NMRI-nu/nu female mice
  • 製剤: In 0.5% methocellulose-0.4% polysorbate-80 (Tween 80)
  • 投薬量: 20 mg/kg
  • 投与方法: Oral administration
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water Insoluble
体内 左から右までの手順で、溶剤を製品に加えることです:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
いい結果が出るために、混じった後、直ちに使うと推めます。
10mg/mL

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 485.94
化学式

C24H25ClFN5O3

CAS No. 439081-18-2
保管
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02795156 Recruiting Non-small Cell Lung Carcinoma|Urothelial Carcinoma|Gastrointestinal Carcinoma, Non-colon|Upper Aerodigestive Tract Carcinoma SCRI Development Innovations, LLC|Foundation Medicine|Boehringer Ingelheim|Bayer September 28, 2016 Phase 2
NCT03054038 Not yet recruiting Non-Small Cell Lung Carcinoma Vanderbilt-Ingram Cancer Center|National Cancer Institute (NCI) February 2017 Phase 1
NCT02979977 Not yet recruiting Squamous Cell Cancers of the Head and Neck Aarti Bhatia|National Comprehensive Cancer Network|Boehringer Ingelheim|Yale University December 2016 Phase 2
NCT02876081 Not yet recruiting SMALL CELL LUNG CARCINOMA Groupe Hospitalier Paris Saint Joseph December 2016 Phase 2
NCT02183883 Recruiting Non-small Cell Lung Cancer University College, London|Boehringer Ingelheim December 2016 Phase 2
NCT02423525 Recruiting Brain Cancer Santosh Kesari|Boehringer Ingelheim|John Wayne Cancer Institute October 2016 Phase 1

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

Related Antibodies

EGFRシグナル伝達経路

EGFR Inhibitors with Unique Features

相関EGFR製品

Tags: Afatinib (BIBW2992)を買う | Afatinib (BIBW2992) ic50 | Afatinib (BIBW2992)供給者 | Afatinib (BIBW2992)を購入する | Afatinib (BIBW2992)費用 | Afatinib (BIBW2992)生産者 | オーダーAfatinib (BIBW2992) | Afatinib (BIBW2992)化学構造 | Afatinib (BIBW2992)分子量 | Afatinib (BIBW2992)代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID