Afatinib (BIBW2992)

製品コードS1011

Afatinib (BIBW2992)化学構造

分子量(MW):485.94

Afatinib (BIBW2992)はEGFR/HER2( EGFR(wt)、EGFR(L858R)、EGFR(L858R/T790M) とHER2を含める)を不可逆に抑制して、無細胞試験でIC50値が0.5 nM,0.4 nM,10 nM 和 14 nMにそれえぞれ分かれることです。

サイズ 価格(税別) 在庫  
JPY 39840.00 あり
JPY 19920.00 あり
JPY 34860.00 あり
JPY 94620.00 あり

文献中の使用例(37)

カスタマーフィードバック(4)

  • Cytoxicity of irreversible EGFR TKIS and ethacrynic acid on breast cells lines. A, Mean IC50 value of Afatinib.

    Oncotarget, 2016, 7(36):58038-58050. Afatinib (BIBW2992) purchased from Selleck.

    Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

  • Inhibition of anchorage-independent growth of lung tumor cell lines by selected inhibitors. Each selected cell line was treated with the indicated inhibitor at 0.1 μM and 1 μM concentrations for two weeks and cell colony size formation was scored under the Nikon inverted-phase microscope.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

    After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of BIBW2992 for 3h,followed by 15-minute stimolation of 100ng/ml EGF

    Dr. Zhang of Tianjin Medical University. Afatinib (BIBW2992) purchased from Selleck.

製品安全説明書

EGFR阻害剤の選択性比較

生物活性

製品説明 Afatinib (BIBW2992)はEGFR/HER2( EGFR(wt)、EGFR(L858R)、EGFR(L858R/T790M) とHER2を含める)を不可逆に抑制して、無細胞試験でIC50値が0.5 nM,0.4 nM,10 nM 和 14 nMにそれえぞれ分かれることです。
ターゲット
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 10 nM 14 nM
体外試験

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzt[|l[UUN3ME2wMlAxPTd{IN88US=> NHL0PYNUSU6JRWK=
KASUMI-1 NHuwcHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33oWWlEPTB;MD6wNFkyOSEQvF2= NX;1cVVEW0GQR1XS
HCC2218 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XEUGlEPTB;MD6wNFk5PyEQvF2= MWDTRW5ITVJ?
KARPAS-45 NGfzZoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2r5dWlEPTB;MD6wNVY4OSEQvF2= NG\QT|NUSU6JRWK=
HSC-4 NVnmenlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwMEG3OFgh|ryP M2X5NHNCVkeHUh?=
CHL-1 NGOwV5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnXNYxrUUN3ME2wMlAyQDN7IN88US=> NF70UJVUSU6JRWK=
KY821 NGLJVI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfnblN7UUN3ME2wMlAzODZizszN MUjTRW5ITVJ?
NCI-N87 NYHY[mc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPETWM2OD1yLkCyO|c{KM7:TR?= NI\qXoFUSU6JRWK=
DOK MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\ZTWM2OD1yLkCzNVk1KM7:TR?= NWX3cYhEW0GQR1XS
DSH1 NHnSNXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPKd2RKSzVyPUCuNFM{OTRizszN Mo\YV2FPT0WU
MDA-MB-175-VII MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXjTWM2OD1yLkCzOFE3KM7:TR?= MWfTRW5ITVJ?
NCI-H2170 M4DBV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHOwOHBKSzVyPUCuNFM4OjhizszN M2DjRnNCVkeHUh?=
BT-474 NVnLeJdRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV[2UlhkUUN3ME2wMlA1QTh4IN88US=> NG\M[odUSU6JRWK=
EFO-27 MlKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHiwVnFKSzVyPUCuNFUyQDJizszN NV\HSXc4W0GQR1XS
NCI-H720 Mn71S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{js[2lEPTB;MD6wOVMzPSEQvF2= NYLkUVMyW0GQR1XS
PC-14 M3vuc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37sXmlEPTB;MD6wOVY3QCEQvF2= NYHlbY97W0GQR1XS
EC-GI-10 NF\ySW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLwWXJQUUN3ME2wMlA2QTF{IN88US=> MVLTRW5ITVJ?
KYSE-450 NVO0eYplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLvTWM2OD1yLkC1PVc5KM7:TR?= MoP1V2FPT0WU
BPH-1 M3HpZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMEW5PFgh|ryP MmX3V2FPT0WU
NCI-H292 MnLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwME[wPUDPxE1? NUm5SIZYW0GQR1XS
H9 NHXaU3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFGxXYNKSzVyPUCuNFcyOzJizszN M3fybHNCVkeHUh?=
NCI-H526 NH[5O2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TPZWlEPTB;MD6wO|gzOyEQvF2= MlTRV2FPT0WU
NCI-H1623 M{TOc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX[5WVh1UUN3ME2wMlA5ODJ3IN88US=> NWOxdWNOW0GQR1XS
KYSE-140 NWP1dGJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrpdmYxUUN3ME2wMlA5OzNizszN NVjsWoR6W0GQR1XS
Ca9-22 NUC3UHFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrtb2ZKSzVyPUCuNFg{PTNizszN Mlv1V2FPT0WU
AU565 Mn7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPERllVUUN3ME2wMlA5PTB2IN88US=> MoLrV2FPT0WU
ZR-75-30 NWCxRZBHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXz6O2VbUUN3ME2wMlA6PTR3IN88US=> NWLTd5IyW0GQR1XS
NCI-H1770 NH:y[o1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMUCyPEDPxE1? MWDTRW5ITVJ?
LB2241-RCC NETHRZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmraTWM2OD1yLkGwPFg1KM7:TR?= MmnRV2FPT0WU
CAL-39 NIXYcnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LvbmlEPTB;MD6xNVc6OiEQvF2= MonFV2FPT0WU
UACC-893 MnzoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwMUG4PFUh|ryP MmfkV2FPT0WU
LU-65 M4nlSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXjTWM2OD1yLkGyOlM{KM7:TR?= MWPTRW5ITVJ?
HN MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMUOwO|ch|ryP M2qzWnNCVkeHUh?=
TI-73 MoLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XlcWlEPTB;MD6xOFcyPSEQvF2= MUnTRW5ITVJ?
KU812 M3XQN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMUW0OVYh|ryP MmraV2FPT0WU
SW13 Mn3LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwMU[yNVYh|ryP MUfTRW5ITVJ?
BB30-HNC MlHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwMU[1O|Yh|ryP M2LReXNCVkeHUh?=
HSC-2 NXzYWXo4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjtTWM2OD1yLkG2PFM4KM7:TR?= NW[yXW5[W0GQR1XS
BV-173 MnHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkmxTWM2OD1yLkG3OVk3KM7:TR?= MnnFV2FPT0WU
CAL-27 MkCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwMUe2N|Yh|ryP M{\pXHNCVkeHUh?=
SBC-1 M1nHWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnq3TWM2OD1yLkG4PVU6KM7:TR?= MXXTRW5ITVJ?
CAL-33 MlX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LmbWlEPTB;MD6yNFE5PCEQvF2= MnjGV2FPT0WU
NCI-H209 MmrqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\vUGZwUUN3ME2wMlIxPDZizszN NWq1dFBbW0GQR1XS
COR-L105 NX63XVU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETJbFRKSzVyPUCuNlExQDRizszN MUHTRW5ITVJ?
HSC-3 NFjqZ|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nwVWlEPTB;MD6yNVE6QCEQvF2= MXHTRW5ITVJ?
NCI-H69 NHm1T2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMkG0OVEh|ryP M4mydXNCVkeHUh?=
MOLT-13 M2nlXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMkO5O|Uh|ryP NWS5S5Q3W0GQR1XS
ML-2 M2LVWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwMkS4NFIh|ryP NXXwfXJiW0GQR1XS
IGROV-1 M4Dtfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrufJNiUUN3ME2wMlI2QTV{IN88US=> MWfTRW5ITVJ?
TK10 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37ufWlEPTB;MD6yOlc{QCEQvF2= NWq1UYxsW0GQR1XS
EoL-1-cell MmP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3ZTWM2OD1yLkK2PFkzKM7:TR?= M4n1bnNCVkeHUh?=
HO-1-N-1 NGPhNGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mly2TWM2OD1yLkK3PFU{KM7:TR?= MkP2V2FPT0WU
BHY NIrhTG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMki2OVUh|ryP NX6wcnpFW0GQR1XS
LU-139 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;4[GRQUUN3ME2wMlMxPTFizszN NEXERVFUSU6JRWK=
23132-87 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXuTWM2OD1yLkOxPVI{KM7:TR?= MkfxV2FPT0WU
ACHN MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTHdYJKSzVyPUCuN|E6QTRizszN MX3TRW5ITVJ?
DoTc2-4510 M1Pubmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwM{KyNVkh|ryP MV\TRW5ITVJ?
BB65-RCC M3nZS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzvTWM2OD1yLkO0OVk{KM7:TR?= MnrOV2FPT0WU
HLE MoDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\SU5Y1UUN3ME2wMlM2ODR4IN88US=> MUPTRW5ITVJ?
HCC1419 MmrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwM{[0NFgh|ryP NUjsT4tPW0GQR1XS
A388 Mnv3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrGTWM2OD1yLkO2PFU4KM7:TR?= MlPvV2FPT0WU
NUGC-3 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHv2eopKSzVyPUCuN|g{PzNizszN NX;YbZVFW0GQR1XS
KYSE-180 NUTGWY9GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHjcWdQUUN3ME2wMlM6ODh7IN88US=> NEjDTpFUSU6JRWK=
TE-6 NWjoOJVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwNECyOFYh|ryP NFnRNnFUSU6JRWK=
A498 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DTV2lEPTB;MD60NFY4PCEQvF2= MoX3V2FPT0WU
NCI-H1648 M1rnUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLtdHNmUUN3ME2wMlQ1OTh{IN88US=> NXP4S3FsW0GQR1XS
DU-145 NF;2NlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXuTWM2OD1yLkS0PFM{KM7:TR?= NEjpUnNUSU6JRWK=
CW-2 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2q2bmlEPTB;MD60OlkyPCEQvF2= M1PwWHNCVkeHUh?=
A431 M2noRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYCyXYVwUUN3ME2wMlQ5OjN|IN88US=> M3P0WHNCVkeHUh?=
SAS MnnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETSOmpKSzVyPUCuOFg{QThizszN MYHTRW5ITVJ?
NCI-H2126 M3r5Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfnfoNKSzVyPUCuOVE6OjZizszN NXjQ[owzW0GQR1XS
NCI-H358 M2CwNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\OZmlEPTB;MD61N|IyKM7:TR?= M{HkUXNCVkeHUh?=
FADU M2jyNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnOfmx4UUN3ME2wMlU1PDB2IN88US=> MmqyV2FPT0WU
ACN M3nLS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzuTWM2OD1yLkW1NFk1KM7:TR?= MmTtV2FPT0WU
HCC70 NEHtUVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLKTWM2OD1yLkW3OlYyKM7:TR?= NFPaeWhUSU6JRWK=
NCI-H1838 M33pSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLmTWM2OD1yLk[wNlk6KM7:TR?= MmfHV2FPT0WU
CAL-54 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jBe2lEPTB;MD62NVYzOSEQvF2= M4HtUXNCVkeHUh?=
NCI-H1975 M3fPW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrJbXNPUUN3ME2wMlYyPzJ6IN88US=> M1;MeHNCVkeHUh?=
COR-L88 M3LOOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwNkSxNVMh|ryP MkmxV2FPT0WU
CTV-1 Mk\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWP3SItTUUN3ME2wMlY1Ozl{IN88US=> M4j4VXNCVkeHUh?=
EW-18 NWSyXmdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfXSZFKSzVyPUCuOlg3QThizszN MYnTRW5ITVJ?
HCC1806 MoPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwNkm2OlYh|ryP MnTRV2FPT0WU
HuP-T4 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3uTWM2OD1yLk[5O|Yh|ryP Ml\oV2FPT0WU
MDA-MB-361 MoDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWG3UpV2UUN3ME2wMlczPjZ{IN88US=> NXP1NXRTW0GQR1XS
NCI-H1573 M3fBZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDCRppKSzVyPUCuO|M3OyEQvF2= NGTNVG9USU6JRWK=
KU-19-19 MnjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnzTWM2OD1yLke3OFY1KM7:TR?= MXrTRW5ITVJ?
COLO-678 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfxR|hKSzVyPUCuPFA5OzRizszN M{HFRXNCVkeHUh?=
C-33-A MmDnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwOEGyPVch|ryP M3vGVHNCVkeHUh?=
Calu-3 M1rlNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;KVlJKSzVyPUCuPFE1OzRizszN Moq2V2FPT0WU
AGS NV;zc5FkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfMN5BOUUN3ME2wMlg{PjR6IN88US=> MnjzV2FPT0WU
SCC-25 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnf6TWM2OD1yLki0NVcyKM7:TR?= NHTrfm5USU6JRWK=
JVM-2 NV72TXh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvMXI1XUUN3ME2wMlg5Ojl7IN88US=> M1jienNCVkeHUh?=
HCE-T NWHVZpJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwOEi0Nlgh|ryP MX;TRW5ITVJ?
ES4 M4nRbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfETWM2OD1yLkm3PFM3KM7:TR?= M3f2R3NCVkeHUh?=
EKVX MkDTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2X5SmlEPTB;MT6wNVA3PCEQvF2= NH3uS5hUSU6JRWK=
D-542MG MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzuTWM2OD1zLkCxNFY1KM7:TR?= NYCxR4lbW0GQR1XS
SW1116 NWj1SXg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\QOpVKSzVyPUGuNFEzQDdizszN M2TPb3NCVkeHUh?=
5637 Mnq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1qzTGlEPTB;MT6wNVUyKM7:TR?= NUjkSY01W0GQR1XS
HT-1376 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\2NplKSzVyPUGuNFE2OTNizszN NUS4OYlXW0GQR1XS
NB69 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWX4SoNmUUN3ME2xMlAzQTR3IN88US=> NYTJe3huW0GQR1XS
YKG-1 MkP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7uN5BKSzVyPUGuNFU1OTlizszN NUCweWEyW0GQR1XS
EW-3 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HLcWlEPTB;MT6wO|g5OyEQvF2= Ml\hV2FPT0WU
GCIY M2\uZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDUTWM2OD1zLkC4NVA1KM7:TR?= M1Kx[nNCVkeHUh?=
SK-MES-1 NWnScWFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXIWJFKSzVyPUGuNVE1QDdizszN NHLQelhUSU6JRWK=
PANC-08-13 M{POWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonYTWM2OD1zLkG2OFE3KM7:TR?= MoDVV2FPT0WU
SK-NEP-1 MnzGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\UTWM2OD1zLkG3OVE{KM7:TR?= M4nMN3NCVkeHUh?=
SW954 NIXyVnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PETGlEPTB;MT6yNFIyPCEQvF2= M2PibHNCVkeHUh?=
NCI-SNU-5 M37zeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTFwMkO5JO69VQ>? NWDs[Hh6W0GQR1XS
SW48 NWDVXXU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTFwMkW0N|Ih|ryP NFXs[YlUSU6JRWK=
HT-3 M2\MOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1OxRWlEPTB;MT6yPFc2OyEQvF2= Mm\MV2FPT0WU
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JVM-3 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTdwOEm1PVkh|ryP NVTNdnk3W0GQR1XS
OAW-28 M2jjPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TMfmlEPTB;Nz65OFU4QCEQvF2= NE\GcnZUSU6JRWK=
KURAMOCHI MlnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTdwOUS4NVEh|ryP Mon3V2FPT0WU
BE-13 MnrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XxcmlEPTB;Nz65PFEyOiEQvF2= M{TSSXNCVkeHUh?=
VMRC-RCZ MojlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjaVHVFUUN3ME24MlAyPjl5IN88US=> NFzD[m1USU6JRWK=
NCI-H727 NEHXXGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRThwMUC0NkDPxE1? M3H1WXNCVkeHUh?=
SW1710 NILzO2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHOzelRKSzVyPUiuNVg2OTVizszN MUDTRW5ITVJ?
D-502MG NW\rZYVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRThwMkmyPFIh|ryP MlfqV2FPT0WU
NCI-H1993 M4S3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2T2Z2lEPTB;OD6zN|Y{OSEQvF2= MXHTRW5ITVJ?
SCC-4 MkPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRThwNESwOVkh|ryP M2DTUnNCVkeHUh?=
HAL-01 NHz5boNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUH0d25ZUUN3ME24MlUyQTFizszN MVrTRW5ITVJ?
GT3TKB Mk[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnBXFhKSzVyPUiuOlc6PjRizszN NFjIc4VUSU6JRWK=
SK-OV-3 MmXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1S1S2lEPTB;OD63NVMzQSEQvF2= Ml;2V2FPT0WU
COLO-829 M12zUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrSTWM2OD16LkiwPVc3KM7:TR?= M2jXO3NCVkeHUh?=
OCI-AML2 NISwZ5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojHTWM2OD16Lkm1OFgyKM7:TR?= NFTo[XRUSU6JRWK=
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BFTC-909 NUXtdphyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TGT2lEPTB;OT6wOlc6QSEQvF2= NVXpdIxZW0GQR1XS
EW-11 Ml3pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7oeY9KSzVyPUmuNVc3PTNizszN NVPJRWlXW0GQR1XS
HCE-4 M{[ydGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn6wTWM2OD17LkKxOVU5KM7:TR?= M2DPdnNCVkeHUh?=
BALL-1 MojtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2q1UWlEPTB;OT6yNVkxPyEQvF2= MlLrV2FPT0WU
SF539 NX24e|d3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIT0W2dKSzVyPUmuNlM2PjJizszN NVTGcVFFW0GQR1XS
CAMA-1 NXfEWotWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXxRoRKSzVyPUmuNlgyOjhizszN M4rVZXNCVkeHUh?=
C32 M1vmeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvoPY1KSzVyPUmuN|MxPjRizszN MVLTRW5ITVJ?
NCI-H1703 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfhTWM2OD17LkO0N|c2KM7:TR?= NHzrVlBUSU6JRWK=
NCI-H1650 MnjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTlwNkC5OFYh|ryP MXfTRW5ITVJ?
NCI-H1563 NVXPO2VUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkS4TWM2OD17Lke2NFMyKM7:TR?= Mn3pV2FPT0WU
CAL-85-1 Mn7MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDp[3pKSzVyPUmuPFc{QDNizszN NFPhWpNUSU6JRWK=
UM-UC-3 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M16wSmlEPTB;OT65OVA{KM7:TR?= MUjTRW5ITVJ?
BxPC-3 NWG3RmdwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\XTWM2OD1zMD6wPVczKM7:TR?= NUTHWmN6W0GQR1XS
MHH-PREB-1 MnW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnf0TWM2OD1zMD6xPVk6KM7:TR?= NE\hZYdUSU6JRWK=
DEL M{Gz[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTFyLkO5OFYh|ryP NVPXXFY{W0GQR1XS
HuCCT1 M1vxV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVz4OmxGUUN3ME2xNE43ODN|IN88US=> NFfwPFhUSU6JRWK=
OVCAR-4 MnzqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTFyLki4N|Uh|ryP MVTTRW5ITVJ?
CAL-72 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Xw[mlEPTB;MUCuPVM6OSEQvF2= MV;TRW5ITVJ?
HCC1954 NFPXcXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELKUGRKSzVyPUGxMlA4PTRizszN NF3kcG9USU6JRWK=
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SK-MEL-24 MlzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTFzLkKzOlYh|ryP NFjRT3NUSU6JRWK=
UACC-62 Mn7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTFzLkKzOlgh|ryP M2GzO3NCVkeHUh?=
NCI-H650 NYHnPWk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\6VYJlUUN3ME2xNU4zPDF6IN88US=> MoWxV2FPT0WU
ALL-PO MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXG2XppRUUN3ME2xNU4zPTF{IN88US=> Mk\BV2FPT0WU
T84 NEn3dJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrEOWVKSzVyPUGxMlM6ODdizszN NYi5OnlIW0GQR1XS
IST-MEL1 NGHFPFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfpe|JkUUN3ME2xNU41PTV7IN88US=> NHHDUZhUSU6JRWK=
SW626 M3LMbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHRTWM2OD1zMT61O|U2KM7:TR?= MlHTV2FPT0WU
RPMI-2650 MnfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlX2TWM2OD1zMT61PFg2KM7:TR?= Mn[2V2FPT0WU
MC-IXC MnrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3i1dmlEPTB;MUGuOlczQCEQvF2= NIPWOGJUSU6JRWK=
HOP-62 NIH2NGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HWc2lEPTB;MUGuOlc3PCEQvF2= NV7rRm9tW0GQR1XS
NOS-1 NHnsPYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPPTWM2OD1zMT63NVA6KM7:TR?= M2rxPHNCVkeHUh?=
SW1573 Mk[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTFzLkeyPVUh|ryP NEixV5RUSU6JRWK=
WM-115 Mlm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vZN2lEPTB;MUGuO|U5QCEQvF2= MULTRW5ITVJ?
HuO9 NV\GOJpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;OVpV1UUN3ME2xNU45Pzd2IN88US=> NGH0XHFUSU6JRWK=
YAPC NHvFPIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVn0XlFXUUN3ME2xNU46OjV7IN88US=> NV75d5N5W0GQR1XS
MDA-MB-453 M3LjSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\DTWM2OD1zMT65OVE2KM7:TR?= NIrm[3RUSU6JRWK=
NCI-H596 MnvXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHuTWM2OD1zMj6wN|Y6KM7:TR?= NG\jPYdUSU6JRWK=
A172 Mn3nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTF{LkC3PVgh|ryP NGW0eHhUSU6JRWK=
RS4-11 NHnKNohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvaW5lwUUN3ME2xNk4yPzJ3IN88US=> NXX0UWs3W0GQR1XS
HCC1937 NIDScXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvWTWM2OD1zMj63OVY1KM7:TR?= M1\nTHNCVkeHUh?=
SW837 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHFbIVrUUN3ME2xNk46ODJ6IN88US=> MmTrV2FPT0WU
NMC-G1 NVjLVFZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYqwO4tJUUN3ME2xNk46OjN2IN88US=> MnHMV2FPT0WU
PFSK-1 M3LqRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInIW5VKSzVyPUGzMlA3KM7:TR?= M{PsVHNCVkeHUh?=
DBTRG-05MG M3zCeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjEWG1nUUN3ME2xN{4xPjN{IN88US=> MmLJV2FPT0WU
SK-UT-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTF|LkGwPFMh|ryP MlXOV2FPT0WU
OVCAR-5 NFzvWXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIe5OYZKSzVyPUGzMlE2QTNizszN M3L2PHNCVkeHUh?=
8505C MkT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvqNYtzUUN3ME2xN{4zODZ5IN88US=> NFLVPJNUSU6JRWK=
SK-MEL-1 NFXXeI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTF|LkexN|Uh|ryP NFv5RZZUSU6JRWK=
LK-2 MmLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIm1eXNKSzVyPUGzMlc3OzlizszN MWXTRW5ITVJ?
OE33 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;PTWM2OD1zMz63PFYh|ryP MVfTRW5ITVJ?
Ramos-2G6-4C10 M4T5PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFq5S|FKSzVyPUG0MlAzODJizszN MXLTRW5ITVJ?
EW-13 NYT2XXpvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\3NlBGUUN3ME2xOE4xOzV{IN88US=> NYr4UYM2W0GQR1XS
NCI-H1793 MmO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHX2fWRKSzVyPUG0MlIxQDdizszN Mo\VV2FPT0WU
BHT-101 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTF2LkK0NUDPxE1? MYLTRW5ITVJ?
RKO MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml6zTWM2OD1zND61NFc2KM7:TR?= MYrTRW5ITVJ?
NEC8 M{HYO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XwS2lEPTB;MUSuOVQ4OiEQvF2= M4jBT3NCVkeHUh?=
PANC-10-05 M3n2fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfZdo9KSzVyPUG0MlYzPDdizszN Ml\KV2FPT0WU
NCI-H2030 Ml\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HtNGlEPTB;MUSuOlQ1QCEQvF2= M{jkS3NCVkeHUh?=
C2BBe1 NF\Ccm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml[zTWM2OD1zND63OlQh|ryP NELvfmJUSU6JRWK=
EM-2 NYnDcWExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvUTWM2OD1zND64OVc3KM7:TR?= MkXGV2FPT0WU
HCC1395 NFnGZmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTIWJRKSzVyPUG0Mlk{OzhizszN NFr3fVNUSU6JRWK=
A2058 M2TvN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoCwTWM2OD1zNT6wOFA6KM7:TR?= M1r6N3NCVkeHUh?=
SW1463 M2j3fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYroRXh4UUN3ME2xOU4xPDh3IN88US=> M1nSUnNCVkeHUh?=
J82 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTF3LkC1O{DPxE1? MnvZV2FPT0WU
CAL-120 MnvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTF3LkG0OFch|ryP M3HRZnNCVkeHUh?=
COLO-824 M{LmfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrtO2oxUUN3ME2xOU4yPTd7IN88US=> MorSV2FPT0WU
LNCaP-Clone-FGC M{f1SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2ntXGlEPTB;MUWuOFI1QCEQvF2= MljhV2FPT0WU
CP66-MEL M2jhNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTF3LkS2PFgh|ryP NHXoUJFUSU6JRWK=
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OVCAR-8 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTF3Lki4OlEh|ryP NGnvU4ZUSU6JRWK=
MFE-280 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTpTWM2OD1zNj6wOFg5KM7:TR?= MV3TRW5ITVJ?
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SW1990 NEnkNFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYiycnBoUUN3ME2xOk4yPzV3IN88US=> MkPiV2FPT0WU
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MFM-223 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1q4bmlEPTB;MU[uN|k3PSEQvF2= MXfTRW5ITVJ?
L-363 MlvsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFGzTXdKSzVyPUG2MlQ2PzdizszN Ml7QV2FPT0WU
MCF7 NEXBS3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfHTWM2OD1zNj60O|I{KM7:TR?= MoH4V2FPT0WU
SK-MEL-3 NW\4XmVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPldZRSUUN3ME2xOk41Pzh5IN88US=> Ml7jV2FPT0WU
HH M3v1TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTF4LkWxOlIh|ryP Moi5V2FPT0WU
no-10 NU\DNVhyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVW5dZp5UUN3ME2xOk43OzR|IN88US=> MUfTRW5ITVJ?
HuP-T3 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUflOpBXUUN3ME2xOk43PTd4IN88US=> NIGzS3ZUSU6JRWK=
QIMR-WIL MorOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTF4LkexNFUh|ryP MnvjV2FPT0WU
NCI-H1092 NGLWd4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTF4LkizNVYh|ryP MnvlV2FPT0WU
MZ2-MEL NUTvOHROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzhTWM2OD1zNj64OFA{KM7:TR?= NVfWSm57W0GQR1XS
ES3 M4nNR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HRd2lEPTB;MU[uPVE{PCEQvF2= MWPTRW5ITVJ?
COLO-684 NXLFOld[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIOwVoVKSzVyPUG2Mlk1PzdizszN NYm1bI1GW0GQR1XS
NCI-H661 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTF4Lkm2PVQh|ryP MnTYV2FPT0WU
CP50-MEL-B M3vWZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTF5LkCzOFMh|ryP MWnTRW5ITVJ?
NCI-H2405 M4XoO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XwZWlEPTB;MUeuNVk4PCEQvF2= NY\tVlllW0GQR1XS
U-2-OS NHXC[YpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTF5LkWzNFch|ryP MYjTRW5ITVJ?
RERF-LC-MS M4f5e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnn0TWM2OD1zNz61OVA5KM7:TR?= M4qxOHNCVkeHUh?=
NCI-H2342 M4fkbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjUTHNKSzVyPUG3MlU2PyEQvF2= Mn\GV2FPT0WU
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MOLT-16 NWrvZlNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTF5Lki5N|Qh|ryP Mne0V2FPT0WU
RH-18 NHn6WYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXG1e2dmUUN3ME2xPE4xODN3IN88US=> NF21Vo9USU6JRWK=
D-283MED NXLkOZU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnEV|RKSzVyPUG4MlAxQDhizszN M2LmVXNCVkeHUh?=
RCC10RGB MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXlTWM2OD1zOD6wOVU6KM7:TR?= MUDTRW5ITVJ?
NCI-H1437 M4LhN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1GwSWlEPTB;MUiuNVY1OSEQvF2= MmSzV2FPT0WU
SW982 NWHUc|RXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvMRZpKSzVyPUG4MlI3PzFizszN MYjTRW5ITVJ?
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A704 MojXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTF6LkS3OVMh|ryP M{T3PXNCVkeHUh?=
ESS-1 MlHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPtTWM2OD1zOD61NlA2KM7:TR?= MVXTRW5ITVJ?
SCH NXLXT3BGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTF6Lk[0OVYh|ryP NFzQR3NUSU6JRWK=
COLO-320-HSR MmLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVX0V|RzUUN3ME2xPE44PDZizszN MUPTRW5ITVJ?
Mo-T NYnqfHJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTF6LkiyNFQh|ryP NEDOXIpUSU6JRWK=
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D-263MG M{Hmb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTKSGtNUUN3ME2zN{45Ozd6IN88US=> MUHTRW5ITVJ?
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Mewo MkjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXW0OWFuUUN3ME2zOE4yOzR7IN88US=> MWLTRW5ITVJ?
22RV1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEP6VmpKSzVyPUO0MlE4PTRizszN MV;TRW5ITVJ?
KM-H2 MlPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjQWIdOUUN3ME2zOE4yPzd7IN88US=> MX7TRW5ITVJ?
NCI-H2122 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPNTWM2OD1|ND6zOFcyKM7:TR?= MmPmV2FPT0WU
ABC-1 NFzaZ4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTN2LkO2PVMh|ryP MVrTRW5ITVJ?
NCI-H1355 Mlr4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTN2LkO4PFkh|ryP MoG2V2FPT0WU
NOMO-1 MofNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjtUYV4UUN3ME2zOE42PzB|IN88US=> MWrTRW5ITVJ?
MZ7-mel NFXtS|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHDO2VKSzVyPUO0MlY1QDdizszN MYDTRW5ITVJ?
NCI-H810 M2PLN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDsdVNKSzVyPUO0MlczPzhizszN MWrTRW5ITVJ?
D-392MG Mlr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXxTWM2OD1|NT6wOVY2KM7:TR?= MmfUV2FPT0WU
LB771-HNC NWDMenNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvNTWM2OD1|NT6xOlU5KM7:TR?= NYPVPI14W0GQR1XS
COLO-679 Mk\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk[wTWM2OD1|NT6zPFgh|ryP M3rMd3NCVkeHUh?=
SK-PN-DW NWPjO4VkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTSTWM2OD1|NT60N|Y6KM7:TR?= MYnTRW5ITVJ?
VA-ES-BJ NXfFVHpIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfLTWM2OD1|NT60OlQ6KM7:TR?= MlyzV2FPT0WU
KNS-42 Ml3ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTN3LkW4NlYh|ryP MWfTRW5ITVJ?
RVH-421 Ml3ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTN3Lke2OFUh|ryP MonYV2FPT0WU
P30-OHK Mn\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXjTWM2OD1|NT64O|UzKM7:TR?= NYHXWGNSW0GQR1XS
G-402 M17pfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1K3ZWlEPTB;M{WuPVg3PyEQvF2= MmDHV2FPT0WU
S-117 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2CxUWlEPTB;M{[uN|AxQCEQvF2= MUnTRW5ITVJ?
RXF393 NUfVT2NET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTN4LkO3PFUh|ryP M1;keXNCVkeHUh?=
LCLC-103H M4nOSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTN4Lke4NFMh|ryP MoDoV2FPT0WU
U-118-MG MlrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;LTWM2OD1|Nj64PFQ4KM7:TR?= M3HvfHNCVkeHUh?=
8-MG-BA NVjuUGxQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnR[GdKSzVyPUO2Mlk1QDNizszN Ml72V2FPT0WU
MFH-ino MlrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3oTWM2OD1|Nz6zN|cyKM7:TR?= M4G1Z3NCVkeHUh?=
NCI-H23 Ml3HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfxTWM2OD1|Nz60NVk3KM7:TR?= NGjrPHhUSU6JRWK=
NCI-H446 NEfMOplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFX1T4ZKSzVyPUO3MlQ5PjJizszN NITY[HBUSU6JRWK=
LU-99A NXrV[ZZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTN5LkW3N|Eh|ryP NFLnT5hUSU6JRWK=
KP-N-YN NX;pOWlDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDsO4d1UUN3ME2zO{43OTl3IN88US=> M1nQXHNCVkeHUh?=
SCC-9 MlPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DlR2lEPTB;M{euO|g{QCEQvF2= M1fmXXNCVkeHUh?=
EFM-19 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTN5Lke5Olch|ryP Mn;PV2FPT0WU
A427 NWG0dFgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEO2UVlKSzVyPUO3MlkyODdizszN NFq1PW9USU6JRWK=
LB831-BLC MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PuXWlEPTB;M{iuOlA{QSEQvF2= NXywdYp{W0GQR1XS
HOS NXTpclNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInhXXFKSzVyPUO5MlYzPzNizszN NF3mOWxUSU6JRWK=
LAN-6 NV6wWHl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M120RmlEPTB;NECuNFEyOiEQvF2= MXnTRW5ITVJ?
U251 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkD1TWM2OD12MD60NFU1KM7:TR?= MnPSV2FPT0WU
SNU-387 NWLyXZM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInMd3dKSzVyPUSwMlQ2PTNizszN NH\pem1USU6JRWK=
DMS-79 NUnBXWJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTRyLkW4PFkh|ryP NX2yfVJ{W0GQR1XS
SK-LU-1 NHjXdXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1H0c2lEPTB;NECuOlU3QCEQvF2= NHPVT3VUSU6JRWK=
HT NGn6VJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTRyLk[2N|kh|ryP MXfTRW5ITVJ?
KP-N-YS NWn1NY9iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{O5W2lEPTB;NECuOlc3QCEQvF2= MYHTRW5ITVJ?
DMS-114 NV3Y[ZFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XONmlEPTB;NECuPFM4PCEQvF2= NGXNT3BUSU6JRWK=
HUTU-80 M{O3bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjuUo1wUUN3ME20NU4xPTZ7IN88US=> M1fXS3NCVkeHUh?=
ONS-76 NI\xOIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mom4TWM2OD12MT60O|A6KM7:TR?= MVvTRW5ITVJ?
A673 M3;hbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4noPGlEPTB;NEGuOVE2PyEQvF2= M4\0R3NCVkeHUh?=
HPAF-II NFzGZmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTRzLk[3NFkh|ryP MW\TRW5ITVJ?
UACC-257 NF;CTlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXrTWM2OD12MT63N|Y6KM7:TR?= M4LxbnNCVkeHUh?=
EW-22 M1zUTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTRzLki2PVch|ryP MXrTRW5ITVJ?
NCI-H1755 MkCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3NTWM2OD12MT64O|I2KM7:TR?= MnHKV2FPT0WU
KYSE-150 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXmcZRvUUN3ME20Nk4yPzh{IN88US=> NX;YTHBpW0GQR1XS
CGTH-W-1 NXfLeoFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrrc2FiUUN3ME20Nk41QTV3IN88US=> M2ixfnNCVkeHUh?=
NB13 NIXTRYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnDWppKSzVyPUSyMlYzOTdizszN M{TmVXNCVkeHUh?=
SW872 MmjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XMeGlEPTB;NEKuOlM{OSEQvF2= NIjVXZNUSU6JRWK=
KP-4 MlXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1WyeWlEPTB;NEKuPFg{OiEQvF2= MkPwV2FPT0WU
HCC38 NYHUZVBtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPsZ|JRUUN3ME20Nk46PjF6IN88US=> Ml3UV2FPT0WU
BB49-HNC MmrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vaTmlEPTB;NEOuNlM2PiEQvF2= Mn7KV2FPT0WU
CAL-62 MkTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHJZ5RKSzVyPUSzMlQxOjhizszN MXrTRW5ITVJ?
NCI-H2029 NH;Kb2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPueoR6UUN3ME20N{42PThzIN88US=> NIW0WHRUSU6JRWK=
M14 NUTRXVd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1qyOGlEPTB;NESuNVM{OiEQvF2= NXHsRXgzW0GQR1XS
COLO-680N MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTR2LkOzPUDPxE1? Mk\QV2FPT0WU
Hs-578-T Mk\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDnPZhKSzVyPUS1MlAzQTRizszN NX7FRpY4W0GQR1XS
MSTO-211H Ml73S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDuN2g{UUN3ME20OU46PDh{IN88US=> MWjTRW5ITVJ?
EW-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TSPWlEPTB;NEWuPVY5QSEQvF2= MVjTRW5ITVJ?
SW948 NVnZeYZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTR4LkS0OlIh|ryP NYi1fodDW0GQR1XS
NCI-H460 M{LnSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjpUoJKSzVyPUS2MlUzOyEQvF2= NGj0cYxUSU6JRWK=
CAS-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTR4Lke3NFEh|ryP Mn30V2FPT0WU
TGBC11TKB Moq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3q1RWlEPTB;NEeuNVc4PyEQvF2= MmXzV2FPT0WU
HD-MY-Z M2rhc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXLPHFKSzVyPUS4Mlc5PiEQvF2= NXnuWVhKW0GQR1XS
NCI-H226 M{nBXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGr1PYlKSzVyPUS5Mlc4QDVizszN M1TqOHNCVkeHUh?=
PA-1 MkT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTR7LkizN|Uh|ryP NV3DXWhIW0GQR1XS
LB2518-MEL NU\uR|gzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrGWHJRUUN3ME20PU45PzJ|IN88US=> MUjTRW5ITVJ?
A101D NVnRNVJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DncWlEPTB;NEmuPVQzPSEQvF2= Mn\1V2FPT0WU
NCI-H2087 M3fn[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTR7Lkm2PFIh|ryP NVew[GpjW0GQR1XS

多くの細胞株試験データを見る場合、クリックしてください

体内試験 Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

お薦めの試験操作(参考用のみ)

キナーゼ試験:

[1]

+ 展開

In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
細胞試験:

[1]

+ 展開
  • 細胞株: NSCLC cells
  • 濃度: 0-10 μM
  • 反応時間: 1 hour
  • 実験の流れ:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (参考用のみ)
動物試験:

[1]

+ 展開
  • 動物モデル: Athymic NMRI-nu/nu female mice
  • 製剤: In 0.5% methocellulose-0.4% polysorbate-80 (Tween 80)
  • 投薬量: 20 mg/kg
  • 投与方法: Oral administration
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water Insoluble
体内 順序で溶剤を入れること:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
10mg/mL

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 485.94
化学式

C24H25ClFN5O3

CAS No. 439081-18-2
保管
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02795156 Recruiting Non-small Cell Lung Carcinoma|Urothelial Carcinoma|Gastrointestinal Carcinoma, Non-colon|Upper Aerodigestive Tract Carcinoma SCRI Development Innovations, LLC|Foundation Medicine|Boehringer Ingelheim|Bayer September 28, 2016 Phase 2
NCT03054038 Not yet recruiting Non-Small Cell Lung Carcinoma Vanderbilt-Ingram Cancer Center|National Cancer Institute (NCI) February 2017 Phase 1
NCT02979977 Not yet recruiting Squamous Cell Cancers of the Head and Neck Aarti Bhatia|National Comprehensive Cancer Network|Boehringer Ingelheim|Yale University December 2016 Phase 2
NCT02876081 Not yet recruiting SMALL CELL LUNG CARCINOMA Groupe Hospitalier Paris Saint Joseph December 2016 Phase 2
NCT02183883 Recruiting Non-small Cell Lung Cancer University College, London|Boehringer Ingelheim December 2016 Phase 2
NCT02423525 Recruiting Brain Cancer Santosh Kesari|Boehringer Ingelheim|John Wayne Cancer Institute October 2016 Phase 1

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

EGFR信号経路図

EGFR Inhibitors with Unique Features

相関EGFR製品

Tags: Afatinib (BIBW2992)を買う | Afatinib (BIBW2992) ic50 | Afatinib (BIBW2992)供給者 | Afatinib (BIBW2992)を購入する | Afatinib (BIBW2992)費用 | Afatinib (BIBW2992)生産者 | オーダーAfatinib (BIBW2992) | Afatinib (BIBW2992)化学構造 | Afatinib (BIBW2992)分子量 | Afatinib (BIBW2992)代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID