Afatinib (BIBW2992)

製品コードS1011

Afatinib (BIBW2992)化学構造

分子量(MW):485.94

Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.

サイズ 価格(税別)  
JPY 39840.00
JPY 19920.00
JPY 34860.00
JPY 94620.00

文献中の使用例(37)

カスタマーフィードバック(4)

  • Cytoxicity of irreversible EGFR TKIS and ethacrynic acid on breast cells lines. A, Mean IC50 value of Afatinib.

    Oncotarget, 2016, 7(36):58038-58050. Afatinib (BIBW2992) purchased from Selleck.

    Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

  • Inhibition of anchorage-independent growth of lung tumor cell lines by selected inhibitors. Each selected cell line was treated with the indicated inhibitor at 0.1 μM and 1 μM concentrations for two weeks and cell colony size formation was scored under the Nikon inverted-phase microscope.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

    After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of BIBW2992 for 3h,followed by 15-minute stimolation of 100ng/ml EGF

    Dr. Zhang of Tianjin Medical University. Afatinib (BIBW2992) purchased from Selleck.

製品安全説明書

EGFR阻害剤の選択性比較

生物活性

製品説明 Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.
ターゲット
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
ErbB4 [2]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 1 nM 10 nM 14 nM
体外試験

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 M2W5W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjFWWhKSzVyPUCuNFA2PzJizszN MYfTRW5ITVJ?
KASUMI-1 NX;aNYVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PZSWlEPTB;MD6wNFkyOSEQvF2= MlrVV2FPT0WU
HCC2218 M{j4T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXWZYVKSzVyPUCuNFA6QDdizszN M33Jc3NCVkeHUh?=
KARPAS-45 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMEG2O|Eh|ryP NEH5b29USU6JRWK=
HSC-4 Ml7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYn0[G5WUUN3ME2wMlAyPzR6IN88US=> MVrTRW5ITVJ?
CHL-1 NXXXVm91T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjPb|NKSzVyPUCuNFE5OzlizszN MmnwV2FPT0WU
KY821 MlrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwMEKwOkDPxE1? NUnPZnE2W0GQR1XS
NCI-N87 M3PCWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mom1TWM2OD1yLkCyO|c{KM7:TR?= M17nN3NCVkeHUh?=
DOK MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXuTWM2OD1yLkCzNVk1KM7:TR?= MlqwV2FPT0WU
DSH1 NYHpdnVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4q0cmlEPTB;MD6wN|MyPCEQvF2= MmnTV2FPT0WU
MDA-MB-175-VII MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnGxTWM2OD1yLkCzOFE3KM7:TR?= M{DmeXNCVkeHUh?=
NCI-H2170 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwMEO3Nlgh|ryP Mn35V2FPT0WU
BT-474 MmfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwMES5PFYh|ryP NX65OFBQW0GQR1XS
EFO-27 M{n2PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzWV45qUUN3ME2wMlA2OTh{IN88US=> NIL5TVZUSU6JRWK=
NCI-H720 NWTYbItOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfjTWM2OD1yLkC1N|I2KM7:TR?= NI\YTGVUSU6JRWK=
PC-14 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHXRo1KSzVyPUCuNFU3PjhizszN NUDyW25KW0GQR1XS
EC-GI-10 NXjQNHNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwMEW5NVIh|ryP MkHtV2FPT0WU
KYSE-450 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF74NohKSzVyPUCuNFU6PzhizszN NIWwXFRUSU6JRWK=
BPH-1 NXLXZpl[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1yxVmlEPTB;MD6wOVk5QCEQvF2= NYfmVoFHW0GQR1XS
NCI-H292 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDsTWM2OD1yLkC2NFkh|ryP NVnSfopIW0GQR1XS
H9 NI[5d3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mom1TWM2OD1yLkC3NVMzKM7:TR?= MVXTRW5ITVJ?
NCI-H526 MlXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMEe4NlMh|ryP NEPSWVRUSU6JRWK=
NCI-H1623 Mn;mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwMEiwNlUh|ryP NH71emtUSU6JRWK=
KYSE-140 NHvq[4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwMEizN{DPxE1? NIrSS2JUSU6JRWK=
Ca9-22 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LjdmlEPTB;MD6wPFM2OyEQvF2= MYLTRW5ITVJ?
AU565 NYHrXI1XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXO4SGRvUUN3ME2wMlA5PTB2IN88US=> M2Gzd3NCVkeHUh?=
ZR-75-30 M1TlRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\4[4xKSzVyPUCuNFk2PDVizszN NE\FZpRUSU6JRWK=
NCI-H1770 M{jGNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\ifIxNUUN3ME2wMlExOjhizszN NXP4WGo1W0GQR1XS
LB2241-RCC MnvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{G1WmlEPTB;MD6xNFg5PCEQvF2= NX\1UWNNW0GQR1XS
CAL-39 NVfnU3kzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7COFJlUUN3ME2wMlEyPzl{IN88US=> MXLTRW5ITVJ?
UACC-893 Mmi0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwMUG4PFUh|ryP NFjI[JhUSU6JRWK=
LU-65 Mk\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\DcYlKSzVyPUCuNVI3OzNizszN NWiwZWl{W0GQR1XS
HN M3[wdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3NTWM2OD1yLkGzNFc4KM7:TR?= MnjLV2FPT0WU
TI-73 M3K3Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjpR484UUN3ME2wMlE1PzF3IN88US=> MWnTRW5ITVJ?
KU812 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7iVWJiUUN3ME2wMlE2PDV4IN88US=> MUfTRW5ITVJ?
SW13 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXyTWM2OD1yLkG2NlE3KM7:TR?= MWHTRW5ITVJ?
BB30-HNC NXizUIpnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnGcm1KSzVyPUCuNVY2PzZizszN MonjV2FPT0WU
HSC-2 NUnjXZpsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwMU[4N|ch|ryP M{m0eXNCVkeHUh?=
BV-173 M{fUeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTvb|NOUUN3ME2wMlE4PTl4IN88US=> MY\TRW5ITVJ?
CAL-27 Ml61S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{T4O2lEPTB;MD6xO|Y{PiEQvF2= MnS5V2FPT0WU
SBC-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3JXW5NUUN3ME2wMlE5QTV7IN88US=> MlfJV2FPT0WU
CAL-33 NFLmcGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTBwMkCxPFQh|ryP MXrTRW5ITVJ?
NCI-H209 NInvNZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7rTWM2OD1yLkKwOFYh|ryP NVvXSHI{W0GQR1XS
COR-L105 NFz5d2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrLSotKSzVyPUCuNlExQDRizszN NHPkN4hUSU6JRWK=
HSC-3 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7XTXRFUUN3ME2wMlIyOTl6IN88US=> NWrKTXR5W0GQR1XS
NCI-H69 NXXyOJNrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojqTWM2OD1yLkKxOFUyKM7:TR?= NVLZSZMzW0GQR1XS
MOLT-13 NGroRlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITrTIZKSzVyPUCuNlM6PzVizszN NIjt[YZUSU6JRWK=
ML-2 Ml;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzoTWM2OD1yLkK0PFAzKM7:TR?= MmL5V2FPT0WU
IGROV-1 M37lUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPKfFh4UUN3ME2wMlI2QTV{IN88US=> M2\Kc3NCVkeHUh?=
TK10 NYXCW3hlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7OTWM2OD1yLkK2O|M5KM7:TR?= MX\TRW5ITVJ?
EoL-1-cell NX:5Tos5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vpemlEPTB;MD6yOlg6OiEQvF2= NVrWUIV{W0GQR1XS
HO-1-N-1 M{\YT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlqzTWM2OD1yLkK3PFU{KM7:TR?= M2XLUHNCVkeHUh?=
BHY MmHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwMki2OVUh|ryP NHi1R|NUSU6JRWK=
LU-139 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPEbnZNUUN3ME2wMlMxPTFizszN NXXoT2NbW0GQR1XS
23132-87 NX[3[YpUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorXTWM2OD1yLkOxPVI{KM7:TR?= M4DvdXNCVkeHUh?=
ACHN Mnj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PoTmlEPTB;MD6zNVk6PCEQvF2= NVLmVnVUW0GQR1XS
DoTc2-4510 NGjSRYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnVUWZKSzVyPUCuN|IzOTlizszN MWTTRW5ITVJ?
BB65-RCC NELFV4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfETWM2OD1yLkO0OVk{KM7:TR?= NYLrenJTW0GQR1XS
HLE MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHROWZKSzVyPUCuN|UxPDZizszN M1\wR3NCVkeHUh?=
HCC1419 M3fMeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4G2SmlEPTB;MD6zOlQxQCEQvF2= NGHTO3JUSU6JRWK=
A388 Mm\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rON2lEPTB;MD6zOlg2PyEQvF2= NF72RWVUSU6JRWK=
NUGC-3 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TofmlEPTB;MD6zPFM4OyEQvF2= MX\TRW5ITVJ?
KYSE-180 NXWxe5puT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwM{mwPFkh|ryP M3rCT3NCVkeHUh?=
TE-6 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\x[o04UUN3ME2wMlQxOjR4IN88US=> Mn\uV2FPT0WU
A498 MmXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLVNmlKUUN3ME2wMlQxPjd2IN88US=> NVf2TGw2W0GQR1XS
NCI-H1648 NELVUYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjJTFFYUUN3ME2wMlQ1OTh{IN88US=> NVHuZoVxW0GQR1XS
DU-145 MmXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwNES4N|Mh|ryP NFH5XWRUSU6JRWK=
CW-2 NELWOZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoW5TWM2OD1yLkS2PVE1KM7:TR?= NHPhd4FUSU6JRWK=
A431 M3jvbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwNEiyN|Mh|ryP MmLNV2FPT0WU
SAS NELVdppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\ZUWlEPTB;MD60PFM6QCEQvF2= NYPqdVB{W0GQR1XS
NCI-H2126 M2\ncWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfmUGFKSzVyPUCuOVE6OjZizszN NE\pb41USU6JRWK=
NCI-H358 M2LIWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVS5c2ViUUN3ME2wMlU{OjFizszN NWS3W5E1W0GQR1XS
FADU M{H4R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3tU4t6UUN3ME2wMlU1PDB2IN88US=> M3v5fHNCVkeHUh?=
ACN MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwNUWwPVQh|ryP NFz4UohUSU6JRWK=
HCC70 MlnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHSTWM2OD1yLkW3OlYyKM7:TR?= NWfYNY5EW0GQR1XS
NCI-H1838 Ml;sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwNkCyPVkh|ryP M4rqUXNCVkeHUh?=
CAL-54 MlvqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV:xfZozUUN3ME2wMlYyPjJzIN88US=> MXvTRW5ITVJ?
NCI-H1975 MnK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLCTWM2OD1yLk[xO|I5KM7:TR?= MXrTRW5ITVJ?
COR-L88 M2T1dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEC2Z|BKSzVyPUCuOlQyOTNizszN M4LTSHNCVkeHUh?=
CTV-1 M13mdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwNkSzPVIh|ryP M2jCRnNCVkeHUh?=
EW-18 M1L6Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3QTWM2OD1yLk[4Olk5KM7:TR?= MlXtV2FPT0WU
HCC1806 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDsTWM2OD1yLk[5OlY3KM7:TR?= MYTTRW5ITVJ?
HuP-T4 NIfyd2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYm5Xo5mUUN3ME2wMlY6PzZizszN MmO5V2FPT0WU
MDA-MB-361 M1y4e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGD5Zm5KSzVyPUCuO|I3PjJizszN NIr6UYxUSU6JRWK=
NCI-H1573 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwN{O2N{DPxE1? M3PPXXNCVkeHUh?=
KU-19-19 MlPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7YSWVKSzVyPUCuO|c1PjRizszN NWjKeJhOW0GQR1XS
COLO-678 MlvOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwOEC4N|Qh|ryP M3\QO3NCVkeHUh?=
C-33-A M1juUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjPTWM2OD1yLkixNlk4KM7:TR?= MnHzV2FPT0WU
Calu-3 NED2ZoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnhPYgxUUN3ME2wMlgyPDN2IN88US=> M2TxUnNCVkeHUh?=
AGS NYPoNpo2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwOEO2OFgh|ryP NH7Xe3RUSU6JRWK=
SCC-25 NIL0TI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlq5TWM2OD1yLki0NVcyKM7:TR?= NU[xepBZW0GQR1XS
JVM-2 NGi3XW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLvTWM2OD1yLki4Nlk6KM7:TR?= NIXRRotUSU6JRWK=
HCE-T NVrEbZBFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HpW2lEPTB;MD64PFQzQCEQvF2= NHjiVmNUSU6JRWK=
ES4 MmnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHTOFNUUUN3ME2wMlk4QDN4IN88US=> M1f2ZnNCVkeHUh?=
EKVX MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTFwMEGwOlQh|ryP MnrrV2FPT0WU
D-542MG MkWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlG5TWM2OD1zLkCxNFY1KM7:TR?= Mmn3V2FPT0WU
SW1116 NX65Z5J5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrQZ5BXUUN3ME2xMlAyOjh5IN88US=> MnTZV2FPT0WU
5637 M2nT[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEe2SHhKSzVyPUGuNFE2OSEQvF2= MnexV2FPT0WU
HT-1376 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fzTWlEPTB;MT6wNVUyOyEQvF2= NF3yT2NUSU6JRWK=
NB69 M4LYfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTFwMEK5OFUh|ryP MkjpV2FPT0WU
YKG-1 NVfke41GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrreG9KSzVyPUGuNFU1OTlizszN M{XGZXNCVkeHUh?=
EW-3 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHyx[41KSzVyPUGuNFc5QDNizszN NELrb2JUSU6JRWK=
GCIY M3v0WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPnS5JKSzVyPUGuNFgyODRizszN M{TLd3NCVkeHUh?=
SK-MES-1 NFfOXVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;mdGlEPTB;MT6xNVQ5PyEQvF2= NHvBSJJUSU6JRWK=
PANC-08-13 NUPKZ4tjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFKyUGVKSzVyPUGuNVY1OTZizszN NYexTG9UW0GQR1XS
SK-NEP-1 NX7Be5lDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI[zRnFKSzVyPUGuNVc2OTNizszN M4DHZnNCVkeHUh?=
SW954 NXexcmRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLjXXFKSzVyPUGuNlAzOTRizszN MYXTRW5ITVJ?
NCI-SNU-5 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rhcWlEPTB;MT6yN|kh|ryP M17VfXNCVkeHUh?=
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OAW-28 NH76VIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTdwOUS1O|gh|ryP MlHPV2FPT0WU
KURAMOCHI MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTdwOUS4NVEh|ryP Mn3GV2FPT0WU
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NCI-H727 MkTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7DTWM2OD16LkGwOFIh|ryP M4LqN3NCVkeHUh?=
SW1710 M1zXcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3jTFZ7UUN3ME24MlE5PTF3IN88US=> NHyx[29USU6JRWK=
D-502MG NFzON5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\mTWM2OD16LkK5NlgzKM7:TR?= MXnTRW5ITVJ?
NCI-H1993 MlzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnjTWM2OD16LkOzOlMyKM7:TR?= NE\LdnZUSU6JRWK=
SCC-4 MmLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{X1S2lEPTB;OD60OFA2QSEQvF2= NYnieVZ6W0GQR1XS
HAL-01 Mof5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRThwNUG5NUDPxE1? MXnTRW5ITVJ?
GT3TKB NGLWUXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTRNHBvUUN3ME24MlY4QTZ2IN88US=> NYGzXmVWW0GQR1XS
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COLO-829 NHLFZ25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\v[XY1UUN3ME24MlgxQTd4IN88US=> MX\TRW5ITVJ?
OCI-AML2 M3L6eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPGVFNKSzVyPUiuPVU1QDFizszN NH6zVYlUSU6JRWK=
OS-RC-2 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTlwMEKxPUDPxE1? M2fxTXNCVkeHUh?=
BFTC-909 NV6zdGt2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETrT2tKSzVyPUmuNFY4QTlizszN NGLTeYxUSU6JRWK=
EW-11 NHXC[ndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnWeVBQUUN3ME25MlE4PjV|IN88US=> NFzKVHZUSU6JRWK=
HCE-4 NV\POlNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Tm[2lEPTB;OT6yNVU2QCEQvF2= M1\KN3NCVkeHUh?=
BALL-1 MnPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml75TWM2OD17LkKxPVA4KM7:TR?= NIfke|lUSU6JRWK=
SF539 NFjFT25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTlwMkO1OlIh|ryP M3\r[3NCVkeHUh?=
CAMA-1 NXe1dXRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPnbZRKSzVyPUmuNlgyOjhizszN MmDDV2FPT0WU
C32 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIW2d3VKSzVyPUmuN|MxPjRizszN MmfXV2FPT0WU
NCI-H1703 NF7rZ2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDzTWM2OD17LkO0N|c2KM7:TR?= MVHTRW5ITVJ?
NCI-H1650 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfl[HN5UUN3ME25MlYxQTR4IN88US=> M4fZTXNCVkeHUh?=
NCI-H1563 NHPnTmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTlwN{[wN|Eh|ryP MVrTRW5ITVJ?
CAL-85-1 MmjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHxTWM2OD17Lki3N|g{KM7:TR?= NEf6UmdUSU6JRWK=
UM-UC-3 MkXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXBTWM2OD17Lkm1NFMh|ryP NI\CSWVUSU6JRWK=
BxPC-3 NUTSeVBUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoGxTWM2OD1zMD6wPVczKM7:TR?= MoDXV2FPT0WU
MHH-PREB-1 M1LRVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfMTWM2OD1zMD6xPVk6KM7:TR?= NYXMfY45W0GQR1XS
DEL M4PUTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlu0TWM2OD1zMD6zPVQ3KM7:TR?= MYLTRW5ITVJ?
HuCCT1 M{\kO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jNd2lEPTB;MUCuOlA{OyEQvF2= M3nGNnNCVkeHUh?=
OVCAR-4 M1rIT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTFyLki4N|Uh|ryP MkjoV2FPT0WU
CAL-72 NH\adVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPSTWM2OD1zMD65N|kyKM7:TR?= NFWwRYZUSU6JRWK=
HCC1954 M4K1NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\GTWM2OD1zMT6wO|U1KM7:TR?= M3LEeHNCVkeHUh?=
EFO-21 M3nYWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXv0WZN[UUN3ME2xNU4yODR3IN88US=> MUHTRW5ITVJ?
FTC-133 NGXrUnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTFzLkG0NFch|ryP MWfTRW5ITVJ?
SK-MEL-24 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrqTWM2OD1zMT6yN|Y3KM7:TR?= Ml3EV2FPT0WU
UACC-62 NInJSYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\wd5pKSzVyPUGxMlI{PjhizszN NUHyS3lTW0GQR1XS
NCI-H650 NXe3O3BXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlq1TWM2OD1zMT6yOFE5KM7:TR?= MVTTRW5ITVJ?
ALL-PO NYHVd4pET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnvXYlYUUN3ME2xNU4zPTF{IN88US=> NIfZS2tUSU6JRWK=
T84 MmDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHEbnRrUUN3ME2xNU4{QTB5IN88US=> NUL5dXduW0GQR1XS
IST-MEL1 MnixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{ThXWlEPTB;MUGuOFU2QSEQvF2= M4PxWHNCVkeHUh?=
SW626 NYrOTnFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTFzLkW3OVUh|ryP NETwUYVUSU6JRWK=
RPMI-2650 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlO4TWM2OD1zMT61PFg2KM7:TR?= MXnTRW5ITVJ?
MC-IXC NH3OVpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\ic2RRUUN3ME2xNU43PzJ6IN88US=> NGLjW2RUSU6JRWK=
HOP-62 NETlfmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknrTWM2OD1zMT62O|Y1KM7:TR?= NV:1[GdVW0GQR1XS
NOS-1 NF;pRVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHmbIJCUUN3ME2xNU44OTB7IN88US=> MXrTRW5ITVJ?
SW1573 M{nvV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPsdHVKSzVyPUGxMlczQTVizszN MVfTRW5ITVJ?
WM-115 NG\pWVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIeyN5dKSzVyPUGxMlc2QDhizszN NX35WJluW0GQR1XS
HuO9 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDZSHBUUUN3ME2xNU45Pzd2IN88US=> MUTTRW5ITVJ?
YAPC NHXxflVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjrUpRKSzVyPUGxMlkzPTlizszN NVXWV4VjW0GQR1XS
MDA-MB-453 NEW0TW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXBN5ZKSzVyPUGxMlk2OTVizszN MYrTRW5ITVJ?
NCI-H596 MojrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVv5[JprUUN3ME2xNk4xOzZ7IN88US=> MnWzV2FPT0WU
A172 NFnme4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnr1TWM2OD1zMj6wO|k5KM7:TR?= NHjpNlhUSU6JRWK=
RS4-11 M3XPT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;ETJh5UUN3ME2xNk4yPzJ3IN88US=> M4ntZ3NCVkeHUh?=
HCC1937 NHOxclNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHveJJKSzVyPUGyMlc2PjRizszN M3frTXNCVkeHUh?=
SW837 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXqTXBKSzVyPUGyMlkxOjhizszN MknrV2FPT0WU
NMC-G1 NIfTOFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nsbWlEPTB;MUKuPVI{PCEQvF2= M{nFOnNCVkeHUh?=
PFSK-1 NInvbnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPKSYFKSzVyPUGzMlA3KM7:TR?= NXvZV4d3W0GQR1XS
DBTRG-05MG M2[3PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLyTWM2OD1zMz6wOlMzKM7:TR?= NIPpdIhUSU6JRWK=
SK-UT-1 M1LwfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PPPGlEPTB;MUOuNVA5OyEQvF2= MVrTRW5ITVJ?
OVCAR-5 MkSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTF|LkG1PVMh|ryP M3HpUnNCVkeHUh?=
8505C MoPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXYeZN1UUN3ME2xN{4zODZ5IN88US=> NVHUXI9uW0GQR1XS
SK-MEL-1 M2rs[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnT4TWM2OD1zMz63NVM2KM7:TR?= M{PhenNCVkeHUh?=
LK-2 MoLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;Bc2lEPTB;MUOuO|Y{QSEQvF2= M{HVcXNCVkeHUh?=
OE33 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIOyOFZKSzVyPUGzMlc5PiEQvF2= NH3ZRXBUSU6JRWK=
Ramos-2G6-4C10 M1XKNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1i3TWlEPTB;MUSuNFIxOiEQvF2= M2TueXNCVkeHUh?=
EW-13 M{jCWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3qTWM2OD1zND6wN|UzKM7:TR?= M2Tw[XNCVkeHUh?=
NCI-H1793 MmXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{WxeGlEPTB;MUSuNlA5PyEQvF2= NFP1doFUSU6JRWK=
BHT-101 M3y0T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2D5VmlEPTB;MUSuNlQyKM7:TR?= Ml\PV2FPT0WU
RKO NH2yRlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlq5TWM2OD1zND61NFc2KM7:TR?= MWTTRW5ITVJ?
NEC8 NYnmNGNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTF2LkW0O|Ih|ryP Mkn4V2FPT0WU
PANC-10-05 Mn\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLiPYFKSzVyPUG0MlYzPDdizszN NXfZb3AyW0GQR1XS
NCI-H2030 NULFPWdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoexTWM2OD1zND62OFQ5KM7:TR?= M1;hNXNCVkeHUh?=
C2BBe1 M2DQemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LFU2lEPTB;MUSuO|Y1KM7:TR?= NFLXNWVUSU6JRWK=
EM-2 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXKO2RUUUN3ME2xOE45PTd4IN88US=> M4jDb3NCVkeHUh?=
HCC1395 MmW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTF2LkmzN|gh|ryP M3TaUXNCVkeHUh?=
A2058 NYLFWIQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoL3TWM2OD1zNT6wOFA6KM7:TR?= MWXTRW5ITVJ?
SW1463 NI\ETWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTF3LkC0PFUh|ryP NVzs[o8xW0GQR1XS
J82 NGPJW|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;C[lFSUUN3ME2xOU4xPTdizszN MUnTRW5ITVJ?
CAL-120 Mm\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTtUGtwUUN3ME2xOU4yPDR5IN88US=> MYPTRW5ITVJ?
COLO-824 Mlr0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jSUGlEPTB;MUWuNVU4QSEQvF2= MVrTRW5ITVJ?
LNCaP-Clone-FGC MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnwTWM2OD1zNT60NlQ5KM7:TR?= Mk\FV2FPT0WU
CP66-MEL NEXaeG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLUTWM2OD1zNT60Olg5KM7:TR?= NGL4[FdUSU6JRWK=
OC-314 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Wy[mlEPTB;MUWuOFcyPCEQvF2= MljnV2FPT0WU
OVCAR-8 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7yb4dKSzVyPUG1Mlg5PjFizszN MoTnV2FPT0WU
MFE-280 NX3oXYJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XlUGlEPTB;MU[uNFQ5QCEQvF2= MmPMV2FPT0WU
MHH-NB-11 M3\HcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTF4LkC4N|kh|ryP NELLN3ZUSU6JRWK=
SW1990 M3jwbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvHTWM2OD1zNj6xO|U2KM7:TR?= MoK5V2FPT0WU
U-266 NX7ScWh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PQZmlEPTB;MU[uNlI6QSEQvF2= Ml;iV2FPT0WU
MFM-223 M4\hTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTF4LkO5OlUh|ryP M1\nPXNCVkeHUh?=
L-363 MnLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3kTWM2OD1zNj60OVc4KM7:TR?= NWnIbHVPW0GQR1XS
MCF7 MorDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvjeZpKSzVyPUG2MlQ4OjNizszN MYnTRW5ITVJ?
SK-MEL-3 MojHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LFd2lEPTB;MU[uOFc5PyEQvF2= M3W2UXNCVkeHUh?=
HH MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXtTWM2OD1zNj61NVYzKM7:TR?= MWnTRW5ITVJ?
no-10 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHaV2xDUUN3ME2xOk43OzR|IN88US=> MXXTRW5ITVJ?
HuP-T3 NX;tXmJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXaPXRSUUN3ME2xOk43PTd4IN88US=> MVPTRW5ITVJ?
QIMR-WIL M37OZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjtWVFKSzVyPUG2MlcyODVizszN MWjTRW5ITVJ?
NCI-H1092 NXPWOoFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXW3fVRnUUN3ME2xOk45OzF4IN88US=> NWT5dGRWW0GQR1XS
MZ2-MEL MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXf4VmZ[UUN3ME2xOk45PDB|IN88US=> MVPTRW5ITVJ?
ES3 MofFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHkTWM2OD1zNj65NVM1KM7:TR?= MmrwV2FPT0WU
COLO-684 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmO5TWM2OD1zNj65OFc4KM7:TR?= NXfrOXg6W0GQR1XS
NCI-H661 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUm3[VBUUUN3ME2xOk46Pjl2IN88US=> NEXyZYpUSU6JRWK=
CP50-MEL-B MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTF5LkCzOFMh|ryP MWDTRW5ITVJ?
NCI-H2405 NHnmR3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIW0eY5KSzVyPUG3MlE6PzRizszN MXTTRW5ITVJ?
U-2-OS M3LOZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LzVGlEPTB;MUeuOVMxPyEQvF2= MnO1V2FPT0WU
RERF-LC-MS MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;QTWM2OD1zNz61OVA5KM7:TR?= MX3TRW5ITVJ?
NCI-H2342 NX34UZE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDEN3RKSzVyPUG3MlU2PyEQvF2= MXfTRW5ITVJ?
ES8 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3BV3pKSzVyPUG3MlYxQDdizszN MYjTRW5ITVJ?
MOLT-16 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzVTYNrUUN3ME2xO{45QTN2IN88US=> NVrGTlVxW0GQR1XS
RH-18 NHe5bIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjoTWM2OD1zOD6wNFM2KM7:TR?= MmPwV2FPT0WU
D-283MED NXe5XlJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjUfHJKSzVyPUG4MlAxQDhizszN NV3YdnhsW0GQR1XS
RCC10RGB NWHFNXl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHWwZXNKSzVyPUG4MlA2PTlizszN MXnTRW5ITVJ?
NCI-H1437 NIj0[nJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3yTWM2OD1zOD6xOlQyKM7:TR?= M3;IUXNCVkeHUh?=
SW982 NE\SPFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUX2Slk5UUN3ME2xPE4zPjdzIN88US=> NYHWS4xlW0GQR1XS
IST-MES1 NGHkT4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXhTWM2OD1zOD60OFI5KM7:TR?= MmPCV2FPT0WU
A704 NInqfVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;NTWM2OD1zOD60O|U{KM7:TR?= NXjiN4d5W0GQR1XS
ESS-1 NG\pZZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYGycFY4UUN3ME2xPE42OjB3IN88US=> M{jSe3NCVkeHUh?=
SCH NWnPUohnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzjNGV2UUN3ME2xPE43PDV4IN88US=> NV;rflFJW0GQR1XS
COLO-320-HSR M{\lSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\XPVZKSzVyPUG4Mlc1PiEQvF2= MmrhV2FPT0WU
Mo-T M{H0WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHO0PHlKSzVyPUG4MlgzODRizszN M4qzcHNCVkeHUh?=
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NCI-H2122 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzBNXIyUUN3ME2zOE4{PDdzIN88US=> M1jY[nNCVkeHUh?=
ABC-1 NGn0dVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkS5TWM2OD1|ND6zOlk{KM7:TR?= M3;4ZnNCVkeHUh?=
NCI-H1355 MmKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTN2LkO4PFkh|ryP MVrTRW5ITVJ?
NOMO-1 M3LGWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzGSmtbUUN3ME2zOE42PzB|IN88US=> MnTWV2FPT0WU
MZ7-mel M2X5TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHpcHpKSzVyPUO0MlY1QDdizszN NUf1b3ZkW0GQR1XS
NCI-H810 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3:xe2lEPTB;M{SuO|I4QCEQvF2= NGfjOldUSU6JRWK=
D-392MG MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXrTWM2OD1|NT6wOVY2KM7:TR?= NE\Ne5ZUSU6JRWK=
LB771-HNC NGTLdplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zoZWlEPTB;M{WuNVY2QCEQvF2= NYfOPIE3W0GQR1XS
COLO-679 NIDZPFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTN3LkO4PEDPxE1? NViyNZo5W0GQR1XS
SK-PN-DW M1e2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPrUFNKSzVyPUO1MlQ{PjlizszN NHfzcGdUSU6JRWK=
VA-ES-BJ NX6zVWFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Hh[GlEPTB;M{WuOFY1QSEQvF2= MWjTRW5ITVJ?
KNS-42 NH[5U4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfHOW1RUUN3ME2zOU42QDJ4IN88US=> MnrwV2FPT0WU
RVH-421 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TpWWlEPTB;M{WuO|Y1PSEQvF2= MoLRV2FPT0WU
P30-OHK MnLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTN3Lki3OVIh|ryP M4f6bXNCVkeHUh?=
G-402 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTN3Lkm4Olch|ryP NHH6TFZUSU6JRWK=
S-117 NUnYdVkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHxTWM2OD1|Nj6zNFA5KM7:TR?= NVi1NIpPW0GQR1XS
RXF393 NVOyfZI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1S3ZWlEPTB;M{[uN|c5PSEQvF2= MorCV2FPT0WU
LCLC-103H M3;0[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWD2dIt7UUN3ME2zOk44QDB|IN88US=> M3HrbnNCVkeHUh?=
U-118-MG NWL3SG9tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fzSmlEPTB;M{[uPFg1PyEQvF2= M3fzd3NCVkeHUh?=
8-MG-BA M1fZb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTN4Lkm0PFMh|ryP MnzvV2FPT0WU
MFH-ino NHK2e|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\TTWM2OD1|Nz6zN|cyKM7:TR?= MlHnV2FPT0WU
NCI-H23 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUKy[5h3UUN3ME2zO{41OTl4IN88US=> NGLo[2FUSU6JRWK=
NCI-H446 NFPT[ohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HMdGlEPTB;M{euOFg3OiEQvF2= M3LYUHNCVkeHUh?=
LU-99A MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvXTWM2OD1|Nz61O|MyKM7:TR?= M3Xt[XNCVkeHUh?=
KP-N-YN NFLS[ppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLEeG9KSzVyPUO3MlYyQTVizszN NHvJOIlUSU6JRWK=
SCC-9 NYDVcoRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\3R2lEPTB;M{euO|g{QCEQvF2= MnXpV2FPT0WU
EFM-19 NELvO2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zzSmlEPTB;M{euO|k3PyEQvF2= NWPacFA2W0GQR1XS
A427 NXPL[|hTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHNcJNZUUN3ME2zO{46OTB5IN88US=> MV\TRW5ITVJ?
LB831-BLC NE\hTXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPnfJZKSzVyPUO4MlYxOzlizszN NUP5WFl3W0GQR1XS
HOS MlPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPsTWM2OD1|OT62Nlc{KM7:TR?= NYjKR4V7W0GQR1XS
LAN-6 M1fS[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknsTWM2OD12MD6wNVEzKM7:TR?= M2\U[nNCVkeHUh?=
U251 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTRyLkSwOVQh|ryP MkTpV2FPT0WU
SNU-387 MkL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2foUGlEPTB;NECuOFU2OyEQvF2= MYnTRW5ITVJ?
DMS-79 NGHRUI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;OTWM2OD12MD61PFg6KM7:TR?= MXHTRW5ITVJ?
SK-LU-1 NV3pV4VFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\YfWZKSzVyPUSwMlY2PjhizszN M3L1VHNCVkeHUh?=
HT NG[3RmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTRyLk[2N|kh|ryP NF30OnlUSU6JRWK=
KP-N-YS NFT6XFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTRyLk[3Olgh|ryP NVjOZpJxW0GQR1XS
DMS-114 NH:yXVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTRyLkizO|Qh|ryP NX71c4ZKW0GQR1XS
HUTU-80 M4nrS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\4S2lEPTB;NEGuNFU3QSEQvF2= MnzsV2FPT0WU
ONS-76 NHS2[lFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFGwSZlKSzVyPUSxMlQ4ODlizszN NWTzfXVzW0GQR1XS
A673 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTRzLkWxOVch|ryP NFzJNWlUSU6JRWK=
HPAF-II MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmj4TWM2OD12MT62O|A6KM7:TR?= M4\ieHNCVkeHUh?=
UACC-257 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPWT5ZKSzVyPUSxMlc{PjlizszN MYjTRW5ITVJ?
EW-22 Mm\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDHbpdrUUN3ME20NU45Pjl5IN88US=> NX73T4FRW0GQR1XS
NCI-H1755 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHuWZRKSzVyPUSxMlg4OjVizszN MWjTRW5ITVJ?
KYSE-150 NF\Y[3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\lN2x3UUN3ME20Nk4yPzh{IN88US=> MlnXV2FPT0WU
CGTH-W-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3NU2RKSzVyPUSyMlQ6PTVizszN M3r1eXNCVkeHUh?=
NB13 NXrlfHR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTR{Lk[yNVch|ryP NFvuRpJUSU6JRWK=
SW872 NIHQZ|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmmxTWM2OD12Mj62N|MyKM7:TR?= M2Dq[3NCVkeHUh?=
KP-4 MnLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HJSmlEPTB;NEKuPFg{OiEQvF2= M2eyRnNCVkeHUh?=
HCC38 MnrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rJOmlEPTB;NEKuPVYyQCEQvF2= NEHYU5ZUSU6JRWK=
BB49-HNC MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHi[2NrUUN3ME20N{4zOzV4IN88US=> NXewOZRkW0GQR1XS
CAL-62 NWTYSZBGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fLbGlEPTB;NEOuOFAzQCEQvF2= MXTTRW5ITVJ?
NCI-H2029 Mn;MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LOb2lEPTB;NEOuOVU5OSEQvF2= MXnTRW5ITVJ?
M14 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\sW2FKSzVyPUS0MlE{OzJizszN MUPTRW5ITVJ?
COLO-680N MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnNNYhKSzVyPUS0MlM{QSEQvF2= M4LiRnNCVkeHUh?=
Hs-578-T MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mly1TWM2OD12NT6wNlk1KM7:TR?= MVvTRW5ITVJ?
MSTO-211H M4rMdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTmcWNKSzVyPUS1Mlk1QDJizszN M3:xOXNCVkeHUh?=
EW-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkX1TWM2OD12NT65Olg6KM7:TR?= MXTTRW5ITVJ?
SW948 NHnR[GlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHKTWM2OD12Nj60OFYzKM7:TR?= NWG1[JZWW0GQR1XS
NCI-H460 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULzRm5[UUN3ME20Ok42OjNizszN NH\lcIdUSU6JRWK=
CAS-1 NUjpWFYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXLTWM2OD12Nj63O|AyKM7:TR?= NYPxd2cyW0GQR1XS
TGBC11TKB MkT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\ZcmlEPTB;NEeuNVc4PyEQvF2= MmL5V2FPT0WU
HD-MY-Z MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHhTWM2OD12OD63PFYh|ryP NHyyZlFUSU6JRWK=
NCI-H226 NXiw[nd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjHbJBKSzVyPUS5Mlc4QDVizszN NWPGeFd{W0GQR1XS
PA-1 NFrFWoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4GxOmlEPTB;NEmuPFM{PSEQvF2= MojNV2FPT0WU
LB2518-MEL MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjMTXNKSzVyPUS5Mlg4OjNizszN M4DMd3NCVkeHUh?=
A101D MmPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTR7Lkm0NlUh|ryP NUDmXXhHW0GQR1XS
NCI-H2087 Mk\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TkU2lEPTB;NEmuPVY5OiEQvF2= M3rjc3NCVkeHUh?=

多くの細胞株試験データを見る場合、クリックしてください

体内試験 Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

お薦めの試験操作(参考用のみ)

キナーゼ試験:

[1]

+ 展開

In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
細胞試験:

[1]

+ 展開
  • 細胞株: NSCLC cells
  • 濃度: 0-10 μM
  • 反応時間: 1 hour
  • 実験の流れ:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (参考用のみ)
動物試験:

[1]

+ 展開
  • 動物モデル: Athymic NMRI-nu/nu female mice
  • 製剤: In 0.5% methocellulose-0.4% polysorbate-80 (Tween 80)
  • 投薬量: 20 mg/kg
  • 投与方法: Oral administration
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
混合させたのち直ちに使用することを推奨します。
10mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 485.94
化学式

C24H25ClFN5O3

CAS No. 439081-18-2
保管
in solvent
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02795156 Recruiting Non-small Cell Lung Carcinoma|Urothelial Carcinoma|Gastrointestinal Carcinoma, Non-colon|Upper Aerodigestive Tract Carcinoma SCRI Development Innovations, LLC|Foundation Medicine|Boehringer Ingelheim|Bayer September 28, 2016 Phase 2
NCT03054038 Not yet recruiting Non-Small Cell Lung Carcinoma Vanderbilt-Ingram Cancer Center|National Cancer Institute (NCI) February 2017 Phase 1
NCT02979977 Not yet recruiting Squamous Cell Cancers of the Head and Neck Aarti Bhatia|National Comprehensive Cancer Network|Boehringer Ingelheim|Yale University December 2016 Phase 2
NCT02876081 Not yet recruiting SMALL CELL LUNG CARCINOMA Groupe Hospitalier Paris Saint Joseph December 2016 Phase 2
NCT02183883 Recruiting Non-small Cell Lung Cancer University College, London|Boehringer Ingelheim December 2016 Phase 2
NCT02423525 Recruiting Brain Cancer Santosh Kesari|Boehringer Ingelheim|John Wayne Cancer Institute October 2016 Phase 1

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

EGFRシグナル伝達経路

EGFR Inhibitors with Unique Features

相関EGFR製品

Tags: Afatinib (BIBW2992)を買う | Afatinib (BIBW2992) ic50 | Afatinib (BIBW2992)供給者 | Afatinib (BIBW2992)を購入する | Afatinib (BIBW2992)費用 | Afatinib (BIBW2992)生産者 | オーダーAfatinib (BIBW2992) | Afatinib (BIBW2992)化学構造 | Afatinib (BIBW2992)分子量 | Afatinib (BIBW2992)代理店
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