Gefitinib (ZD1839)

製品コードS1025

Gefitinib (ZD1839)化学構造

分子量(MW):446.90

Gefitinib (ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.

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JPY 31706.00
JPY 24402.00
JPY 44820.00

文献中の使用例(92)

カスタマーフィードバック(13)

  • Perturbation of EGFR by its ligand EGF and gefitinib (ZD-1839 Iressat; inhibits EGFR) produces opposite responses in the predicted EGFR target genes SOCS2 and NR2E1.

    Mol Syst Biol 2011 7, 486. Gefitinib (ZD1839) purchased from Selleck.

    Effects of shRNA-mediated RECK depletion on EGFR signaling in MEFs. (a) Immunoblotting (IB) of the indicated proteins in wild-type MEFs transduced with the indicated shRNAs and cultured for 48 h in the presence of 0.1% dimethyl sulfoxide (DMSO; vehicle) or 1 mM gefitinib (S1025, Selleck Chemicals,Houston, TX, USA). (b) Immunoprecipitation from whole lysates of cells from panel a with an anti-phosphorylated tyrosine (pTyr) antibody. Precipitates from 500 mg protein in whole cell lysates (upper) or 20 mg protein in whole cell lysates (lower) were analyzed by IB with anti-EGFR antibody.

    Oncogene 2010 30, 737-750. Gefitinib (ZD1839) purchased from Selleck.

  • (B–C) LNCaP (B) and LNCaP-AI (C) cells were transiently transfected with sPLA2-IIa(-800)-Luc (0.5 μg). The cells were then treated with Erlotinib (20 μM), Gefitinib (20 μM), Lapatinib (20 μM), CI-1033 (8 μM), LY294002 (20 lM) and Bortezomib (20 μM) without or with EGF (100 ng/ml) for 24 h. Luciferase assay was performed according to a standard protocol with Renilla luciferase as an internal control. Data are presented as the mean (±SD) of duplicate values of a representative experiment that was independently repeated for five times.

    Carcinogenesis 2010 31, 1948–1955 . Gefitinib (ZD1839) purchased from Selleck.

    LNCaP-AI cells were starved in 1% stripped medium for 24 h. The cells were then treated with Erlotinib (20 μM), Gefitinib (20 μM), Lapatinib (20 μM), CI-1033 (8 μM), LY294002 (20 μM) and Bortezomib (20 μM) for 24 h. Cell culture medium was collected from each sample and subjected to ELISA for sPLA2-IIa. The condition medium samples were diluted 10 times for ELISA. Average of duplicate samples was converted to nanogram per milliliter against standard curve. The data represent one of five repeated experiments.

     

     

    Carcinogenesis 2010 31, 1948–1955. Gefitinib (ZD1839) purchased from Selleck.

  • Susceptibility of lung cancer cells to cytolytic activity of NK-92 cells after treatment with EGFR inhibitors. Three lung cancer cells were untreated (open circle) or treated with 10 μM erlotinib or gefitinib (black filled square or black filled triangle) for 24 hours. The lung cancer cells were cocultured with NK-92 cells at indicated effector to target ratio (E:T ratio). To determine the specificity of NKG2D-mediated cytolysis of lung cancer cells, NK-92 cells were preincubated with blocking mAb against NKG2D before the assay (gray filled square and triangle) and correspond-ing isotype mAb (open square and triangle).

    J Immunother 2011 34(4), 372-81. Gefitinib (ZD1839) purchased from Selleck.

    Suppression of EGFR signaling by Gefitinib is dose dependent and non- toxic at millimolar concentrations.Results from plaque reduction tests of Hep2 cells infected with VACV(12.5pfu/well) treated with a serial dilution of Gefitinib (1000-0.01 m) and analyzed for (A)proliferation as indicator of cytotoxicity,(B) IC50 of plaque size inhibition, (C)dose dependent inhibition of EGFR-ERK1/2signaling and VACV proteins by Western blot analysis (pEGFR detection was obtained from a different experiment with identicals ettings) and (D)dose dependent inhibition of orthopoxvirus genome replication by real-time PCR.Untreated VACV infectedcells and uninfected cells are shown as controls in the right panel.

    Antiviral Res 2010 89, 64-70. Gefitinib (ZD1839) purchased from Selleck.

  • A circular zone of EGFR activated but uninfected cells facilitate virus induced plaque development , efficiently blocked by Gefitinib. (A)Immun of luorescent staining of aplaque reduction tests with Hep2 cells 24,48,72 and 96 h after VACV infection (6.25pfu/chamber). VACV infected cells(green) were visualized by human IgG directed to orthopoxviruses (VIG) detected with a secondary FITC labelled antibody. Uninfected cells with activated EGFR signaling(red) are detected with a secondary Cy3labelled antibody. Positive cells for both , VACV and phosphorylated EGFR are shown in yellow(merge). Cellular nuclei are counterstained with DAPI. (B)Immunofluorescent staining of a plaque reduction test as described for (A) and treated with three different Gefitinib concentrations (1000 nM, 1 nM, and 0.01 nM) . The test was analyzed 96h afterVACV infection.Uninfected cells are shown as controls. Magnification100×.(For interpretation of the references to color in this figure legend , the reader is referred to the web version of the article.)

     

     

    Antiviral Res 2010 89, 64-70. Gefitinib (ZD1839) purchased from Selleck.

    The EGF-dependent increased association of PCM1 and AZI1 requires EGFR kinase activity. ZD1839 (Iressa)—EGFR tyrosine kinase inhibitor.

    Mol Biosyst 2011 7, 3223-33. Gefitinib (ZD1839) purchased from Selleck.

  • Inhibition of 5-HT-induced 5-HT3A and 5-HT3AB receptor currents.

    Eur J Pharmacol, 2017, 821:21-28. Gefitinib (ZD1839) purchased from Selleck.

    Reduction of GPER expression in HCC1806 cells after treatment with gefitinib. (A) Concentration dependence. HCC1806 cells were treated with 50-500 nM gefitinib for 48 h. GPER was detected by western blotting. (B) Time dependence. HCC1806 cells were treated with 200 nM gefitinib for 24-96 h. ap<0.05 vs. control; bp<0.001 vs. control. Mean values and SE of three independent experiments are shown. (C) Representative western blotting of concentration dependence. (D) Representative western blotting of time dependence

    Oncol Rep, 2017, 37(2):1212-1218. Gefitinib (ZD1839) purchased from Selleck.

  • Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 215496. Gefitinib (ZD1839) purchased from Selleck.

    Breast cancer cells were pretreated with 100ng/ml EGF for 15 min and then treated with the indicated concentrations of  Gefitinib for 24 hours.

     

     

    2010 Dr. Zhang of Tianjin Medical University. Gefitinib (ZD1839) purchased from Selleck.

  • MTT assay result. 0-500nM Gefitinib treated with H1299, H358, H25 and HCC827 cell lines by 72h, Proliferation rate was tested.

     

     

    2010 Dr. Vicky Tin from University of Hong Kong. Gefitinib (ZD1839) purchased from Selleck.

製品安全説明書

EGFR阻害剤の選択性比較

生物活性

製品説明 Gefitinib (ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.
特性 A potent EGFR tyrosine kinase inhibitor.
ターゲット
Tyr1173 (NR6W cells) [1] Tyr1173 (NR6wtEGFR cells) [1] Tyr992 (NR6wtEGFR cells) [1] Tyr992 (NR6W cells) [1]
26 nM 37 nM 37 nM 57 nM
体外試験

Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low-EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition. Gefitinib effectively blocks the phosphorylation of PLC-γ, with IC50 of 27nM, in NR6W cells. The NR6wtEGFR and NR6M cell lines has low levels of PLC-γ phosphorylation but the level in the NR6M cell line is more resistant to inhibition by Gefitinib with IC50 of 43 nM and 369 nM, respectively. Gefitinib inhibits Akt phosphorylations, with IC50 of 220 and 263nM, in the low-EGFR- and -EGFRvIII-expressing cell lines, respectively. Gefitinib in the dose range from 0.1 to 0.5μM significantly facilitates, rather than abrogates, colony formation of NR6M cells. However, at a concentration of 2 μM Gefitinib completely blocks NR6M colony formation. Gefitinib rapidly and in a dose-dependent manner inhibits EGFR and ERK phosphorylation up to 72 hours after EGF stimulation in both the high- and low-EGFR-expressing cell lines. [1] Gefitinib is the monolayer growth of these EGF-driven untransformed MCF10A cells with an IC50 of 20 nM. [2] The combination of Gefitinib (0.2 μM and 0.5 μM) with irradiation lead to a significant growth inhibition in LoVo cells, compared with radiation alone.. [3]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KB M3fEeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDD[oRKSzVyPUCuNFU1KM7:TR?= MkC3NVY2OTZ2N{O=
NIH3T3 MlXqSpVv[3Srb36gRZN{[Xl? M4XNR|AvOiEQvF2= M2rwSFIhcA>? M1nicmROW09? M4\xNmlvcGmkaYTpc44hd2ZiRVfGJJN1cW23bHH0[YQhcHWvYX6g[ZJjSjFiYYX0c5Bpd3OyaH;yfYxifGmxbjD3bZRpKEmFNUCgc4YhOC5yMUS0JO69VQ>? M{niTFE3PDhyMki0
COS7 MoGxSpVv[3Srb36gRZN{[Xl? MmWwPVYh|ryP MmHyTY5pcWKrdHnvckBw\iCqdX3hckBLSUt{IG[2NVdHKG23dHHueEBmgHC{ZYPz[YQ> MVSxO|E4QDd{Mh?=
A549 M2PHNWN6fG:2b4jpZ{BCe3OjeR?= Ml\EPVYhcA>? NVHYWoNjTE2VTx?= M{DjZmlEPTB;MUOuOVkh|ryP M37WblE5OzF|OEC3
K562 MXjDfZRwfG:6aXOgRZN{[Xl? Ml:2PVYhcA>? NGXX[lBFVVOR M4TKSGlEPTB;OT6zOkDPxE1? M1\LW|E5OzF|OEC3
MDA-MB-231 MVPDfZRwfG:6aXOgRZN{[Xl? MoPCPVYhcA>? NEO1SXdFVVOR M{H3SWlEPTB;M{[uOlEh|ryP MnrlNVg{OTN6MEe=
MOLT4 M3rOeGN6fG:2b4jpZ{BCe3OjeR?= M1WxSlk3KGh? NVr0TJB[TE2VTx?= M4fqTmlEPTB;MUWuNFIh|ryP MmHPNVg{OTN6MEe=
MCF7 MYXDfZRwfG:6aXOgRZN{[Xl? MXi1NEDPxE1? M1TQ[FczKGh? NYDMWHhNUUN3ME2xNk4xPSEQvF2= MmCzNVg4PzF6MUm=
BT474 MkDyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVe3NkBp Mkj5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCEVES3OEBk\WyuczDveoVz\XiycnXzd4lv\yCHUlLiNkB4cXSqIFXDOVAhd2ZiMD6zJO69VQ>? NGe2WlEyQTB{OESyOC=>
HN5 Mof2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTTO|IhcA>? M3jEfmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSF61JINmdGy|IH;2[ZJmgHC{ZYPzbY5oKEWJRmKge4l1cCCHQ{WwJI9nKDBwMEGg{txO MVixPVAzQDR{NB?=
BA/F3 MVfDfZRwfG:6aXOgRZN{[Xl? NWrEXVMyPzJiaB?= Mn\xR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgRmEwTjNiY3XscJMh\XiycnXzd4lv\yCHR1\SJGw5PTiUIH31eIFvfCC5aYToJGlEPTBib3[gNE4xOTB6IN88US=> NUPkcFVSOTl{M{myNlk>
NIH3T3 Mlm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzZbG42PzJiaB?= MmTBS5Jwf3SqIHnubIljcXSrb36gc4YhdW:3c3WgUmlJNzOWMzDj[YxteyCneIDy[ZN{cW6pIHXyRlIh\2WwZTD3bZRpKEmFNUCgc4YhOC53NDFOwG0> MVixPVY3PTN5Nx?=
MCF7 MX NEj0XGFHfW6ldHnvckBCe3OjeR?= M1PPR|MxKG2rbh?= NF[zSW5KdmirYnn0bY9vKG:oIFLDVnAh\XiycnXzd4VlKHerdHigTWM2OCCxZjCxMlEh|ryP MliwNVk6OzJ7NkC=
A431 MlewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLQc|cyOCEQvF2= M1rY[|czKGh? MoDTS2k2OD1yLkWxOEDPxE1? MnXONVk6Pjl2NkW=
A431 MYDLbY5ie2ViQYPzZZk> M{LaNFAvOSEQvF2= MXuxJIg> NH;2XWpKdmirYnn0bY9vKG:oIFXHSk1qdmS3Y3XkJGVITlJicHjvd5Bpd3K7bHH0bY9v MWixPVk3QTR4NR?=
A431 MlrjT4lv[XOnIFHzd4F6 NHjj[|QyODBizszN MoLoNVAhdWmw NHP4boVRem:ub37n[YQhcW6qaXLpeI9zgSCjY4Tpeol1gSCxZjDFS2YucW6mdXPl[EBGT0[UIIDoc5NxcG:{eXzheIlwdg>? MYKxPVk3QTR4NR?=
Sf9 M2G2fWtqdmG|ZTDBd5NigQ>? MnizNVAhdWmw NYnndm5oTE2VTx?= NF:zZ4VKdmirYnn0bY9vKG:oIFXHSnIh\XiycnXzd4VlKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhemWlZYD0c5Ih[XW2b4Doc5NxcG:{eXzheIlwdiC5aYToJGlEPTBib3[gNE4xOzNizszN NIPWeW8zODB3NkSyOS=>
NCI-H1975 NV;OemF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDROUDPxE1? NWLEfIp4PzJiaB?= NV;xVJQ{UUN3ME24MlI3KM7:TR?= NEjoco4zODF3MU[3NC=>
NCI-H1975 NInDbJNMcW6jc3WgRZN{[Xl? NHL1d4oyOCEQvF2= M2qwOGlvcGmkaYTpc44hd2ZiRVfGVkBifXSxcHjvd5Bpd3K7bHH0bY9v MXmyNFE2OTZ5MB?=
NCI-H1975 MYDGeY5kfGmxbjDBd5NigQ>? MY[xNEDPxE1? MnjYTY5pcWKrdHnvckBw\iCHUlLCNkBifXSxcHjvd5Bpd3K7bHH0bY9v MWiyNFE2OTZ5MB?=
NCI-H1975 MYHGeY5kfGmxbjDBd5NigQ>? Moq0OUDPxE1? MmTROFghcA>? MnPBTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCjc4Pld5Nm\CCjczDhZ5RqfmG2aX;uJI9nKGOjc4Dhd4UuOw>? M{XCfFIxOTVzNkew
A375 M3KxfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrHeFlNPDhiaB?= MlfzTWM2OD1{MD61OUDPxE1? NV7RcXAzOjB|MES1N|c>
SMMC7721 NWniTYdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUKwW21EPDhiaB?= NXrpZnBbUUN3ME2zN{4yOiEQvF2= M3eybVIxOzB2NUO3
DU145 NUPhNWJtS3m2b4TvfIlkKEG|c3H5 M1vtdFUh\A>? MmTaSG1UVw>? NXPSb5RLUUN3ME20Nk4yPyEQvF2= MWqyNFQ3PjV3NR?=
MIAPaCa2 M1;lUGN6fG:2b4jpZ{BCe3OjeR?= M1HwfVUh\A>? NEe4R2tFVVOR NXXGXnR5UUN3ME21NE43OiEQvF2= NE\qUoQzODR4NkW1OS=>
PANC1 NWjZWXc3S3m2b4TvfIlkKEG|c3H5 MkP5OUBl M{fycWROW09? MoG2TWM2OD12MD60NkDPxE1? NE\RPY4zODR4NkW1OS=>
PC9 NXW4R|E3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFXHSnIu\GWoaXPp[Y51KGi3bXHuJHBEQSClZXzsd{B4cXSqIFXDOVAhd2ZiMD6wNVch|ryP M{jpZlIyOjB6OECy
PC9 M1ntZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHfyc5d1cC2{ZYPpd5RidnRiaIXtZY4hWEN7IHPlcIx{KGW6cILld5NqdmdiRVfGVkBGPzR4X1G3OVAwXDd7MF2gcZV1[W62IIfpeIghTUN3MDDv[kA4KM7:TR?= NWf1dXVHOjF{MEi4NFI>
PC3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrrNVAh|ryP NYDEeolIPzJiaB?= NX7lbFNbTE2VTx?= NILlNZNKSzVyPUeuOEDPxE1? MWOyNVM2OzV2Nh?=
MDA-MB-468 NG\nT4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3n3WFExOCEQvF2= NHH2VoE1QCCq NUW1PJV[TE2VTx?= M2DD[mFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5 NHrVcI8zOTR{OU[zNi=>
Plasmodium falciparum NG\yblRyUFSVIIDyc4ZqdGmwZzDmc5IhcW6qaXLpeI9zeyCxZjDQcIF{dW:maYXtJIZidGOrcHHyeY0heHKxbHnm[ZJifGmxbh?= MYCyNVgyPzB2NR?=
NCI-H1993 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfnSIM4OiCq NF\KNVJFVVOR NIPsTWFKSzVyPUCuNUDPxE1? M1XiV|IyQTF4NEOz
NCI-H292 MnniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYq3NkBp MWTEUXNQ NUTYN|NOUUN3ME2wMlAzKM7:TR?= M3XuPFIyQTF4NEOz
A431 Mo\oT4lv[XOnIFHzd4F6 M3;sZ|IhcA>? Mme3SG1UVw>? M1TxSWlvcGmkaYTpc44hd2ZiRVfGVkBxcG:|cHjvdplt[XSrb36gbY4hTUeILYP0bY12dGG2ZXSgbJVu[W5iQUSzNUB4cXSqIFnDOVAhd2ZiMD6wNFEh|ryP NH:yRYIzOjFyMUGzNi=>
MCF7 NXmxNWk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjCdoIyODEEoN88[{9uVA>? M4e1RVQ5KGh? M{nTc2ROW09? M2LBU2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDveoVz\XiycnXzd4lv\yCHR1\SJIdmdmVid3n0bEBKSzVyIH;mJFEzNjB3IN88US=> M1PBSlIzOTF7MUOw
BT474 MYLDfZRwfG:6aXOgRZN{[Xl? MWexNEDPxE1? NXHaWFYzPDhiaB?= MVXDfZRwfG:6aXPpeJkh[WejaX7zeEB{\XK3bT3zeIFzfmWmIHj1cYFvKEKWNEe0JINmdGy| NGLiTHczOjF|OEOwPC=>
MCF7 MUHDfZRwfG:6aXOgRZN{[Xl? MnXiNVAh|ryP MYG0PEBp MVfDfZRwfG:6aXPpeJkh[WejaX7zeEB{\XK3bT3zeIFzfmWmIHj1cYFvKE2FRkegZ4VtdHNib4\ldk1mgHC{ZYPzbY5oKEW{YlKyJINmdGy| NW\ON2J2OjJzM{izNFg>
HCC827 MlK5T4lv[XOnIFHzd4F6 MofYNE4yOjVizszN M1zxTVI1KGh? M1LWd2ROW09? NFP4NWhKdmirYnn0bY9vKG:oIFXHSnIh\GWuIFW3OFYuSTd3MDDteZRidnRiWUGwOlgh[XW2b4Doc5NxcG:{eXzheIlwdg>? NFjvT2IzOjN|OUO0Ni=>
HCC827 MmnFT4lv[XOnIFHzd4F6 Mlz2NE4yOjVizszN NV7xS3lCOjRiaB?= M2XvbWROW09? MVXJcohq[mm2aX;uJI9nKEWJRmKg[IVtKEV5NE[tRVc2OCCvdYThcpQudWWmaXH0[YQhTXKtIIDoc5NxcG:{eXzheIlwdg>? MoixNlI{Ozl|NEK=
HCC827 NV73TYZRU2mwYYPlJGF{e2G7 MofNNE4yOjVizszN NUjHTHdPOjRiaB?= MoXtSG1UVw>? MmT6TY5pcWKrdHnvckBw\iCHR1\SJIRmdCCHN{S2MWE4PTBibYX0ZY51NW2nZHnheIVlKEGtdDDwbI9{eGixconsZZRqd25? NYnGXZl4OjJ|M{mzOFI>
A431 MVfLbY5ie2ViQYPzZZk> NHnZZmIyODBizszN MXmzNEBucW5? M17TdmlvcGmkaYTpc44hd2ZiRVfGVkBl\XKrdnXkJIZzd21iaIXtZY4hSTR|MTDj[YxtKG2nbXLyZY5mKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YheG:ueT3HcJUuXHm{IIDoc5NxcG:{eXzheIlwdiC5aYToJGlEPTBib3[gNU4xQCEQvF2= NXTHTXZsOjJ4OUi3PFI>
H460 NGrNNm1EgXSxdH;4bYMhSXO|YYm= MY[3NkBp MljQTWM2OD13LkW5JO69VQ>? NV7WbWRsOjJ5Mke0OFk>
HT-29 NHnLdJFEgXSxdH;4bYMhSXO|YYm= Mn7hO|IhcA>? Ml;xTWM2OD1|LkO2JO69VQ>? Ml3ZNlI4Ojd2NEm=
SGC7901 MWDDfZRwfG:6aXOgRZN{[Xl? MmDvO|IhcA>? MX;JR|UxRTFyLkK2JO69VQ>? MljaNlI4Ojd2NEm=
A498 NETye|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3qxXWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUS5PEBk\WyuczDlfJBz\XO|aX7nJGVITlJiYX7kJHNTSyC5aYToJGlEPTBib3[gPE43KM7:TR?= MXGyNlgyQDh2OB?=
Calu3 MUHDfZRwfG:6aXOgRZN{[Xl? NIPjS|MyOCEQvHevcWw> NYfMXFdpPzJiaB?= NVyzNm81UUN3ME2xMlYh|ryP MVmyN|EyPjF4OB?=
FADU NF7kfZBEgXSxdH;4bYMhSXO|YYm= NEPYZVQyOCEQvHevcWw> NEL3XVY4OiCq MXHJR|UxRTBwMEWg{txO M3ywOlI{OTF4MU[4
HCC827 MnuzR5l1d3SxeHnjJGF{e2G7 MnzYNVAh|rypL33M MnTXO|IhcA>? Ml;DTWM2OD1yLkCwNVUh|ryP Mnr6NlMyOTZzNki=
PC9 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;DNVAh|rypL33M NVrBfXNwPzJiaB?= NXztNlhvUUN3ME2wMlAxOTRizszN MlXVNlMyOTZzNki=
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IGROV-1 NIHiR3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vIWWlEPTB;Mj6zNVI{PyEQvF2= NFy4cYZUSU6JRWK=
JVM-3 NFXPOWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jvSWlEPTB;Mj6zOFY1OyEQvF2= M1XmXHNCVkeHUh?=
NCI-H2170 NEfCTVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLDN3JKSzVyPUKuN|Q4QDNizszN M2HCUHNCVkeHUh?=
EW-18 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fuWWlEPTB;Mj6zOVQ4OSEQvF2= M{fNWnNCVkeHUh?=
KU812 M1zvUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mme5TWM2OD1{LkO2O|c6KM7:TR?= NUfwd4liW0GQR1XS
NY NYHEO29TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF64XmdKSzVyPUKuN|czPyEQvF2= Mlu2V2FPT0WU
HTC-C3 NIHzO4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTqe5FKSzVyPUKuOFIzPjdizszN NWnHS|JuW0GQR1XS
CFPAC-1 NGWzVIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPTenNrUUN3ME2yMlQ{QDZ2IN88US=> M4joTXNCVkeHUh?=
HH MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjIOYtVUUN3ME2yMlQ6QDV2IN88US=> NWDNeoJJW0GQR1XS
MKN7 MlvNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIr6TnBKSzVyPUKuOlI4PDhizszN M{T1UHNCVkeHUh?=
TE-8 NUHOdpNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\OUGlEPTB;Mj62N|Y2OyEQvF2= NGL0NoZUSU6JRWK=
MC-IXC MoftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYO3[I5SUUN3ME2yMlY1PDV|IN88US=> MonMV2FPT0WU
DMS-79 MnHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnm4TWM2OD1{Lk[5Nlg1KM7:TR?= MWLTRW5ITVJ?
Detroit562 M2HYS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XFcmlEPTB;Mj62PVg1PSEQvF2= M13WZ3NCVkeHUh?=
HuP-T4 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTJwN{K4NVgh|ryP M3Pj[XNCVkeHUh?=
QIMR-WIL NF\pdmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPjTWM2OD1{Lke1PVUzKM7:TR?= M3\r[3NCVkeHUh?=
BB65-RCC NVfycmZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTJwOEC3NVMh|ryP NIGyeVdUSU6JRWK=
PC-3 MkTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTjXZFKSzVyPUKuPFM{OTdizszN MUnTRW5ITVJ?
OVCAR-3 M4L2SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH75NZhKSzVyPUKuPFU2QTRizszN NEfGO3RUSU6JRWK=
KYSE-510 M3XDVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{SwNGlEPTB;Mj64Olc5PiEQvF2= M1POOXNCVkeHUh?=
HC-1 NYXIcnBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDyTWM2OD1{Lkm0NFEzKM7:TR?= Mkm5V2FPT0WU
NCI-H1693 NVPRWFMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\xRmZCUUN3ME2yMlk2QDl5IN88US=> NXXxNpJPW0GQR1XS
DU-4475 NYHZNoh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXaTWM2OD1{Lkm5NFUzKM7:TR?= M3P6OnNCVkeHUh?=
COLO-680N NEnqWnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTNwMEC0PVUh|ryP MojnV2FPT0WU
MN-60 NIqyWVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjEZ4VKSzVyPUOuNFQ6PzRizszN MnH2V2FPT0WU
BCPAP M1e4Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDVTWM2OD1|LkC4Nlk2KM7:TR?= M{PpT3NCVkeHUh?=
647-V NHLqN4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTNwMU[yNkDPxE1? NXrNUYVUW0GQR1XS
HT-1376 NGXSWIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3[3XGlEPTB;Mz6yNFUxPiEQvF2= Mm\5V2FPT0WU
NCI-H1793 M4LoVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfhbFlKSzVyPUOuNlExQThizszN M3\xPXNCVkeHUh?=
SW1463 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTNwMk[xPVIh|ryP MXHTRW5ITVJ?
NCI-H727 M{PEfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfWRohJUUN3ME2zMlM5PTh2IN88US=> Mkf6V2FPT0WU
LB771-HNC MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILk[WZKSzVyPUOuN|kyOjZizszN NETyNVdUSU6JRWK=
D-542MG M1HOeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXCNWxqUUN3ME2zMlQ1OjJ{IN88US=> M2TiNHNCVkeHUh?=
NTERA-S-cl-D1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrOU3JKSzVyPUOuOFQ6PTdizszN MULTRW5ITVJ?
C8166 MnTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonETWM2OD1|LkS2OVIyKM7:TR?= MnnvV2FPT0WU
639-V MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnMUoZXUUN3ME2zMlU4Pzl{IN88US=> MkTnV2FPT0WU
TE-1 NIjXdopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7HSo9KSzVyPUOuOVkyPjlizszN M3jEeXNCVkeHUh?=
OAW-28 Mk\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTNwNUm0NlYh|ryP NW\yRnRWW0GQR1XS
SK-LU-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTNwNkC2OFUh|ryP NISzXJhUSU6JRWK=
CaR-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTNwNkGwOFgh|ryP M3\EVHNCVkeHUh?=
A2780 M4Dubmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnznTWM2OD1|Lk[0NFg6KM7:TR?= MYPTRW5ITVJ?
C2BBe1 MnLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnroTWM2OD1|Lk[0OFA4KM7:TR?= MVTTRW5ITVJ?
SK-MES-1 NVj6U5p5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;1Z|BKSzVyPUOuOlQ3OTRizszN MX3TRW5ITVJ?
PANC-10-05 NXfG[nd{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTNwN{KwO|Ih|ryP NGX5OXdUSU6JRWK=
J-RT3-T3-5 NXznZm9QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HaXWlEPTB;Mz63OVQxPiEQvF2= NEnke25USU6JRWK=
ES4 NXnZNI45T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4S5OWlEPTB;Mz64NlI5PiEQvF2= MnvSV2FPT0WU
NCI-H28 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknLTWM2OD1|LkiyPVYyKM7:TR?= M3PRR3NCVkeHUh?=
NCI-H1155 M3;MOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HBeWlEPTB;Mz64OFE2QSEQvF2= MmOzV2FPT0WU
KURAMOCHI M4SwdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTNwOE[wOVYh|ryP M1fTVXNCVkeHUh?=
NCI-H69 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX[2TG1bUUN3ME2zMlkxOTd6IN88US=> NGnOUoFUSU6JRWK=
IST-MES1 MmfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4m2SWlEPTB;Mz65OFAzQSEQvF2= NXTve4d1W0GQR1XS
NH-12 M1nH[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH[2O|BKSzVyPUOuPVQyQDdizszN M4HD[XNCVkeHUh?=
JVM-2 NXK0e|UzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH:5b|NKSzVyPUOuPVQ4PTJizszN MmXCV2FPT0WU
EW-16 MmHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTNwOUW1O|ch|ryP M3vrenNCVkeHUh?=
NCI-H441 M4ey[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\C[odpUUN3ME2zMlk4ODF2IN88US=> NWC4TYdDW0GQR1XS
RCC10RGB NIHXUJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHu4ZZRKSzVyPUSuNFEzPDZizszN NITC[XhUSU6JRWK=
TCCSUP Mmi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTRwMUGwOUDPxE1? MlnEV2FPT0WU
HL-60 M2W0UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3znT2lEPTB;ND6xNlI1OSEQvF2= MmW4V2FPT0WU
EW-11 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDrO4JGUUN3ME20MlE{OjZzIN88US=> M4jtdnNCVkeHUh?=
KARPAS-299 NGXCRXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{ftXWlEPTB;ND6zNVAyOyEQvF2= NVvifY5nW0GQR1XS
SNU-C2B MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;PUWlEPTB;ND6zOFY5PiEQvF2= M2nhTXNCVkeHUh?=
LU-139 NI\FbHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7NR3JKSzVyPUSuN|czPDdizszN M3rTTHNCVkeHUh?=
HCC1937 NE\Fc2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTRwM{e5PVMh|ryP NVnFVpVEW0GQR1XS
GR-ST NHj3VZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLuTWM2OD12LkSzNVgh|ryP Mk\YV2FPT0WU
SK-OV-3 NYHRTnhqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTRwNE[wOFIh|ryP MkT4V2FPT0WU
A172 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFn5dFZKSzVyPUSuOVU2OjFizszN NWXkUWdMW0GQR1XS
NB10 NInFZVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHmOoE4UUN3ME20MlU6PzhzIN88US=> NUC2RpZVW0GQR1XS
P30-OHK NFLpWHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mny0TWM2OD12LkixPVI6KM7:TR?= NF7QPY9USU6JRWK=
KYSE-520 NF[3dYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTtR|dKUUN3ME20Mlg5ODF6IN88US=> M1\obHNCVkeHUh?=
KNS-62 MmW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zZZWlEPTB;ND65NFgxPyEQvF2= NXfYVodWW0GQR1XS
ES1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTRwOU[wN|Uh|ryP NHG4ZYlUSU6JRWK=
KOSC-2 MnHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGD2TIJKSzVyPUSuPVk6PTlizszN NUPldnI5W0GQR1XS
TE-9 NE\pd2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TaeGlEPTB;NT6wNVUzPSEQvF2= MY\TRW5ITVJ?
NCI-H1838 M2TYfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDpSlVKSzVyPUWuNFIxPzZizszN NX\3UnloW0GQR1XS
KP-N-YN NWjudZlDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITIXlRKSzVyPUWuNVI2QTFizszN M2nHd3NCVkeHUh?=
ALL-PO M4rJbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnhWlV4UUN3ME21MlIzPTh5IN88US=> NYHXNmhrW0GQR1XS
NOMO-1 NHjZN2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITPNXpKSzVyPUWuNlMyPzZizszN MkLoV2FPT0WU
CGTH-W-1 NGT1OXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTVwM{i1PFQh|ryP NF;FW4ZUSU6JRWK=
ATN-1 MmnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\ETXYzUUN3ME21MlQyOTh2IN88US=> Mkm4V2FPT0WU
AGS NIHFVGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnsTWM2OD13LkS5OlE5KM7:TR?= Mne5V2FPT0WU
SW13 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjpTWM2OD13LkWzNlY2KM7:TR?= MnP2V2FPT0WU
SW1990 Ml;oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrYTWM2OD13Lk[yNlg2KM7:TR?= NXXGdGdbW0GQR1XS
BFTC-905 MmTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4i1PGlEPTB;NT62OVg4QCEQvF2= MlHNV2FPT0WU
RMG-I NIrxWnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTVwNkW5OFIh|ryP NHG1bVVUSU6JRWK=
HD-MY-Z MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTVwNki1PFEh|ryP MWHTRW5ITVJ?
HCC1187 NF7vZ|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlz1TWM2OD13LkexNFMzKM7:TR?= M2noPXNCVkeHUh?=
HCC2998 NETld3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nt[GlEPTB;NT63NVg4PyEQvF2= NEf1[olUSU6JRWK=
RT-112 NULITHNCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIW2NZZKSzVyPUWuPVAzPDVizszN NGTxTYlUSU6JRWK=
CAKI-1 Mn7ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3W3e2lEPTB;Nj6wNFk5PSEQvF2= M4LoZXNCVkeHUh?=
HDLM-2 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XBO2lEPTB;Nj6wNVQ5QSEQvF2= NHLhRXZUSU6JRWK=
TE-10 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTZwMES4N|Mh|ryP M4PZfXNCVkeHUh?=
KE-37 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LkUmlEPTB;Nj6wO|I2QCEQvF2= M1TWSXNCVkeHUh?=
RCM-1 Ml7BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2L1PGlEPTB;Nj6wO|cyQSEQvF2= NXzDR4FsW0GQR1XS
Mewo NWPBOJIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTZwMUG0PFch|ryP MnXLV2FPT0WU
L-428 NXXFUlh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVr2RWZ2UUN3ME22MlE5ODN5IN88US=> MUHTRW5ITVJ?
8-MG-BA MmLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTZwMUmzO|kh|ryP NVi4SnlYW0GQR1XS
SK-MEL-28 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDk[I9KSzVyPU[uNlA6PjdizszN NYLhfo1OW0GQR1XS
VA-ES-BJ MknmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTZwM{C0OlIh|ryP NXrPfotOW0GQR1XS
CAL-120 NXv5fGFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LueWlEPTB;Nj60OVE3OiEQvF2= MoHXV2FPT0WU
GAMG MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTZwNUC2NkDPxE1? NWLpd2sxW0GQR1XS
MSTO-221H NITmOWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPMTWM2OD14LkWxNVch|ryP NX3odXFRW0GQR1XS
GCT M1TJTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTZwNUOzPFch|ryP MXHTRW5ITVJ?
SH-4 Ml\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7nOGNKSzVyPU[uOVg5PDRizszN MULTRW5ITVJ?
Calu-3 M4qwVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\YZ3ZKSzVyPU[uOlU2PjhizszN MnHhV2FPT0WU
SK-HEP-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mof2TWM2OD14LkexO|U{KM7:TR?= MWHTRW5ITVJ?
PFSK-1 MonxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDXT4hxUUN3ME22Mlc{PDd6IN88US=> Mn\KV2FPT0WU
NB12 NHrnSVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HBS2lEPTB;Nj63PFQxPCEQvF2= M1\GWnNCVkeHUh?=
A388 NFPlVG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[5SZI2UUN3ME22Mlg6PTJizszN MYLTRW5ITVJ?
KLE NYDKOnBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXESWUxUUN3ME22Mlk3PTF4IN88US=> MWTTRW5ITVJ?
TE-11 NInQVmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHSTWM2OD15LkC0PVY4KM7:TR?= MoGwV2FPT0WU
NCI-H2405 MmTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HwOWlEPTB;Nz6wPFM6OyEQvF2= Mn3RV2FPT0WU
OVCAR-4 M4H6UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rVSGlEPTB;Nz6xOVM2KM7:TR?= M3nRc3NCVkeHUh?=
KP-N-YS NIrUdGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7vZVhKSzVyPUeuNVgyPCEQvF2= M{\yc3NCVkeHUh?=
NOS-1 M2rSUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2T5dWlEPTB;Nz6yOVgzQCEQvF2= M3nDUnNCVkeHUh?=
DMS-114 M1nwZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nRT2lEPTB;Nz6yPVY{OSEQvF2= NFroNWdUSU6JRWK=
NCI-H2030 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTdwM{O2PVgh|ryP M1S2c3NCVkeHUh?=
HEL M4DxUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTdwM{e1NlEh|ryP NV\keop[W0GQR1XS
CAL-62 NV3IdY1mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTdwM{m4OlYh|ryP MVHTRW5ITVJ?
COLO-668 M37rZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7TNIs3UUN3ME23MlQ{QTZ5IN88US=> M1;OVXNCVkeHUh?=
SKG-IIIa Mm\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFX3PY9KSzVyPUeuOFU{QDFizszN MlezV2FPT0WU
HCC1419 NWroT4dOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M321[mlEPTB;Nz60Olg{OyEQvF2= MmjHV2FPT0WU
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COLO-829 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPpTWRKSzVyPUeuOlY1PjNizszN Mne1V2FPT0WU
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T98G NEDRTnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIq4PHNKSzVyPUO3Mlg3OzVizszN NYfoUFQ6W0GQR1XS
NB14 Mni0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTN6LkS1OFQh|ryP MmjQV2FPT0WU
D-423MG MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DaOWlEPTB;M{iuOFg3QSEQvF2= MmTwV2FPT0WU
NCI-H510A NF\x[pZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTN6Lk[0OVEh|ryP MWHTRW5ITVJ?
NMC-G1 NUiwbm1jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTN6LkeyNlIh|ryP NF3Mdm1USU6JRWK=
SW948 NEjMR4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4[0c2lEPTB;M{iuPFk1QSEQvF2= NHjvOldUSU6JRWK=
MFM-223 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXm4OmM{UUN3ME2zPE46PDNzIN88US=> MVTTRW5ITVJ?
PAN1 MnnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVK1ZnRiUUN3ME2zPE46QTF7IN88US=> M{Xr[3NCVkeHUh?=
MZ7-mel NVS1XZlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvnTWM2OD1|OT6xNVk6KM7:TR?= NFzHblhUSU6JRWK=
COLO-679 M1vDNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrxUWlKSzVyPUO5Mlk4ODhizszN MUDTRW5ITVJ?
SW872 NFmyXnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTRyLkKwN|Eh|ryP MmnmV2FPT0WU
HT-1197 M{X3SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjkR5V2UUN3ME20NE4zQDZ7IN88US=> MWTTRW5ITVJ?
ES6 M4r1ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXf2U25FUUN3ME20NE41PTV{IN88US=> M{\GNXNCVkeHUh?=
SNU-387 MmHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmP6TWM2OD12MD64NlM5KM7:TR?= NILwcHRUSU6JRWK=
T47D MmDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH76UYVKSzVyPUSxMlAyQTJizszN NYH4U5hoW0GQR1XS
G-402 NXT4OmtjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrFeohKSzVyPUSxMlA5ODlizszN NUn1UFQ4W0GQR1XS
MZ1-PC MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYW4ZlBZUUN3ME20NU45OSEQvF2= MVjTRW5ITVJ?
SW1417 M2LBemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2mxdGlEPTB;NEKuN|A{KM7:TR?= NGPlSW1USU6JRWK=
RERF-LC-MS NWrmV|ByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLXcGdKSzVyPUSyMlUxQDdizszN NGX2VHBUSU6JRWK=
SF539 MlPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XmWWlEPTB;NEKuOVUzQSEQvF2= MUHTRW5ITVJ?
ESS-1 NFTUdldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PqXWlEPTB;NEOuOVU2QCEQvF2= NUT1V2s5W0GQR1XS
RO82-W-1 NHfqfGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFu1TZJKSzVyPUSzMlYyPTNizszN M3foUnNCVkeHUh?=
S-117 M2PzNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTR|Lk[5OVgh|ryP MXLTRW5ITVJ?
SW756 NYLOU4c5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVz2e5d{UUN3ME20N{45OjR{IN88US=> MlL1V2FPT0WU
CP66-MEL NX21WGk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDHTWM2OD12NT63NVQ{KM7:TR?= MXzTRW5ITVJ?
H-EMC-SS NWOzNoc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTR3Lke2PVMh|ryP M2GzPXNCVkeHUh?=
NCI-H2052 NXOy[nJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfDOXJ{UUN3ME20OU46ODJ5IN88US=> MWjTRW5ITVJ?
SW684 M1L4PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mle2TWM2OD12Nz6wNFgyKM7:TR?= NXeweWFkW0GQR1XS
HCC1569 M4nLS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrYTWM2OD12Nz6xOlU5KM7:TR?= M1HlZnNCVkeHUh?=
KGN NFnzT3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTR5LkOzNVEh|ryP MUjTRW5ITVJ?
LCLC-103H NFTiW4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXxNGhKSzVyPUS3MlQ1ODRizszN NX;PeZJ7W0GQR1XS
SW780 NHjlNJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHl[XFKSzVyPUS3MlY{PTFizszN Mne0V2FPT0WU
NCI-H1703 NIThcG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;PTWM2OD12OD6zN|UzKM7:TR?= MV3TRW5ITVJ?
HCC1395 NH\XepFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvCTWM2OD12OD63OFMzKM7:TR?= MY\TRW5ITVJ?

多くの細胞株試験データを見る場合、クリックしてください

体内試験 Gefitinib (100 mg/kg) improves the anti-tumor effect of radiotherapy in LoVo tumor xenografts. [3] Gefitinib treatment of nude mice bearing established human GEO colon cancer xenografts reveals a reversible dose-dependent inhibition of tumor growth because GEO tumors resumes the growth rate of controls at the end of the treatment. [4]

お薦めの試験操作(参考用のみ)

細胞試験: [1]
+ 展開
  • 細胞株: NR6, NR6M and NR6W cells
  • 濃度: 0-2 μM
  • 反応時間: 72 hours
  • 実験の流れ: Exponentially growing cells including NR6, NR6M, NR6M and NR6W cells are seeded in sextuple in 96-well plates at a concentration of 2000 cells/well, allowed to adhere and subsequently washed in PBS and incubated overnight in medium containing 0.5% FCS. Cells are then treated with varying concentrations (0-2 μM) of Gefitinib or the solute control DMSO and EGF. The optimal EGF concentration for inducing proliferation of NR6wtEGFR and NR6W cells has previously been determined and hence NR6wtEGFR and NR6W cells are supplemented with 10 nM and 0.1 nM EGF, respectively. EGF is not added to NR6 and NR6M cells. After 72 hours the amount of cells are measured by performing a MTT proliferation assay.
    (参考用のみ)
動物試験:[3]
+ 展開
  • 動物モデル: Female nude mice (cba nu/nu) aged 8–10 weeks are intra-dermal injected with LoVo cells.
  • 製剤: 0.5% polysorbate
  • 投薬量: 100 mg/kg
  • 投与方法: Once daily by oral administration (0.1 mL/10 g body weight) for 14 days
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 89 mg/mL (199.14 mM)
Ethanol 4 mg/mL (8.95 mM)
Water Insoluble
体内 左から右までの手順で、溶剤を製品に加えることです:
1% CMC Na
いい結果が出るために、混じった後、直ちに使うと推めます。
30mg/mL

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 446.90
化学式

C22H24ClFN4O3

CAS No. 184475-35-2
保管
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03050164 Completed Bioequivalence Study Hunan Kelun Pharmaceutical Co., Ltd. September 8, 2016 Phase 1
NCT02856893 Not yet recruiting NSCLC European Organisation for Research and Treatment of Cancer - EORTC|AstraZeneca March 2017 Phase 2
NCT02976116 Recruiting NSCLC Hutchison Medipharma Limited December 2016 Phase 2
NCT02951637 Not yet recruiting Lung Adenocarcinoma Shanghai Chest Hospital|Ruijin Hospital|Changhai Hospital December 2016 Phase 2
NCT02930954 Not yet recruiting Non-small-cell Lung Cancer Caicun Zhou|Tongji University November 2016 Phase 2
NCT02929693 Enrolling by invitation Cancer Shanghai University of Traditional Chinese Medicine|Shanghai Chest Hospital|Shanghai Pulmonary Hospital, Shanghai, China October 2016 Phase 3

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    I try to dissolve Gefitinib (ZD1839) in 0.5% methylcellulose+0.2% Tween 80 for in vivo experiments. However, when I prepare the mixture, it forms precipitates. Exists another way to dissolve completely the compound?

  • 回答:

    S1025 can be dissovled in both 5% DMSO+corn oil and 5% DMSO+30% PEG 300+5% Tween 80+ddH2O at 2.5 mg/ml clearly. It dissolves in DMSO not readily, please sonicate and warm it in water bath at about 45 degree, and dissolve it clearly first. Then add other solvent.

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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID