Gefitinib (ZD1839)

製品コードS1025

Gefitinib (ZD1839)化学構造

分子量(MW):446.90

Gefitinib (ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.

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文献中の使用例(91)

カスタマーフィードバック(12)

  • Perturbation of EGFR by its ligand EGF and gefitinib (ZD-1839 Iressat; inhibits EGFR) produces opposite responses in the predicted EGFR target genes SOCS2 and NR2E1.

    Mol Syst Biol 2011 7, 486. Gefitinib (ZD1839) purchased from Selleck.

    Effects of shRNA-mediated RECK depletion on EGFR signaling in MEFs. (a) Immunoblotting (IB) of the indicated proteins in wild-type MEFs transduced with the indicated shRNAs and cultured for 48 h in the presence of 0.1% dimethyl sulfoxide (DMSO; vehicle) or 1 mM gefitinib (S1025, Selleck Chemicals,Houston, TX, USA). (b) Immunoprecipitation from whole lysates of cells from panel a with an anti-phosphorylated tyrosine (pTyr) antibody. Precipitates from 500 mg protein in whole cell lysates (upper) or 20 mg protein in whole cell lysates (lower) were analyzed by IB with anti-EGFR antibody.

    Oncogene 2010 30, 737-750. Gefitinib (ZD1839) purchased from Selleck.

  • (B–C) LNCaP (B) and LNCaP-AI (C) cells were transiently transfected with sPLA2-IIa(-800)-Luc (0.5 μg). The cells were then treated with Erlotinib (20 μM), Gefitinib (20 μM), Lapatinib (20 μM), CI-1033 (8 μM), LY294002 (20 lM) and Bortezomib (20 μM) without or with EGF (100 ng/ml) for 24 h. Luciferase assay was performed according to a standard protocol with Renilla luciferase as an internal control. Data are presented as the mean (±SD) of duplicate values of a representative experiment that was independently repeated for five times.

    Carcinogenesis 2010 31, 1948–1955 . Gefitinib (ZD1839) purchased from Selleck.

    LNCaP-AI cells were starved in 1% stripped medium for 24 h. The cells were then treated with Erlotinib (20 μM), Gefitinib (20 μM), Lapatinib (20 μM), CI-1033 (8 μM), LY294002 (20 μM) and Bortezomib (20 μM) for 24 h. Cell culture medium was collected from each sample and subjected to ELISA for sPLA2-IIa. The condition medium samples were diluted 10 times for ELISA. Average of duplicate samples was converted to nanogram per milliliter against standard curve. The data represent one of five repeated experiments.

     

     

    Carcinogenesis 2010 31, 1948–1955. Gefitinib (ZD1839) purchased from Selleck.

  • Susceptibility of lung cancer cells to cytolytic activity of NK-92 cells after treatment with EGFR inhibitors. Three lung cancer cells were untreated (open circle) or treated with 10 μM erlotinib or gefitinib (black filled square or black filled triangle) for 24 hours. The lung cancer cells were cocultured with NK-92 cells at indicated effector to target ratio (E:T ratio). To determine the specificity of NKG2D-mediated cytolysis of lung cancer cells, NK-92 cells were preincubated with blocking mAb against NKG2D before the assay (gray filled square and triangle) and correspond-ing isotype mAb (open square and triangle).

    J Immunother 2011 34(4), 372-81. Gefitinib (ZD1839) purchased from Selleck.

    Suppression of EGFR signaling by Gefitinib is dose dependent and non- toxic at millimolar concentrations.Results from plaque reduction tests of Hep2 cells infected with VACV(12.5pfu/well) treated with a serial dilution of Gefitinib (1000-0.01 m) and analyzed for (A)proliferation as indicator of cytotoxicity,(B) IC50 of plaque size inhibition, (C)dose dependent inhibition of EGFR-ERK1/2signaling and VACV proteins by Western blot analysis (pEGFR detection was obtained from a different experiment with identicals ettings) and (D)dose dependent inhibition of orthopoxvirus genome replication by real-time PCR.Untreated VACV infectedcells and uninfected cells are shown as controls in the right panel.

    Antiviral Res 2010 89, 64-70. Gefitinib (ZD1839) purchased from Selleck.

  • A circular zone of EGFR activated but uninfected cells facilitate virus induced plaque development , efficiently blocked by Gefitinib. (A)Immun of luorescent staining of aplaque reduction tests with Hep2 cells 24,48,72 and 96 h after VACV infection (6.25pfu/chamber). VACV infected cells(green) were visualized by human IgG directed to orthopoxviruses (VIG) detected with a secondary FITC labelled antibody. Uninfected cells with activated EGFR signaling(red) are detected with a secondary Cy3labelled antibody. Positive cells for both , VACV and phosphorylated EGFR are shown in yellow(merge). Cellular nuclei are counterstained with DAPI. (B)Immunofluorescent staining of a plaque reduction test as described for (A) and treated with three different Gefitinib concentrations (1000 nM, 1 nM, and 0.01 nM) . The test was analyzed 96h afterVACV infection.Uninfected cells are shown as controls. Magnification100×.(For interpretation of the references to color in this figure legend , the reader is referred to the web version of the article.)

     

     

    Antiviral Res 2010 89, 64-70. Gefitinib (ZD1839) purchased from Selleck.

    The EGF-dependent increased association of PCM1 and AZI1 requires EGFR kinase activity. ZD1839 (Iressa)—EGFR tyrosine kinase inhibitor.

    Mol Biosyst 2011 7, 3223-33. Gefitinib (ZD1839) purchased from Selleck.

  • Reduction of GPER expression in HCC1806 cells after treatment with gefitinib. (A) Concentration dependence. HCC1806 cells were treated with 50-500 nM gefitinib for 48 h. GPER was detected by western blotting. (B) Time dependence. HCC1806 cells were treated with 200 nM gefitinib for 24-96 h. ap<0.05 vs. control; bp<0.001 vs. control. Mean values and SE of three independent experiments are shown. (C) Representative western blotting of concentration dependence. (D) Representative western blotting of time dependence

    Oncol Rep, 2017, 37(2):1212-1218. Gefitinib (ZD1839) purchased from Selleck.

    Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 215496. Gefitinib (ZD1839) purchased from Selleck.

  • Breast cancer cells were pretreated with 100ng/ml EGF for 15 min and then treated with the indicated concentrations of  Gefitinib for 24 hours.

     

     

    2010 Dr. Zhang of Tianjin Medical University. Gefitinib (ZD1839) purchased from Selleck.

    MTT assay result. 0-500nM Gefitinib treated with H1299, H358, H25 and HCC827 cell lines by 72h, Proliferation rate was tested.

     

     

    2010 Dr. Vicky Tin from University of Hong Kong. Gefitinib (ZD1839) purchased from Selleck.

製品安全説明書

EGFR阻害剤の選択性比較

生物活性

製品説明 Gefitinib (ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.
特性 A potent EGFR tyrosine kinase inhibitor.
ターゲット
Tyr1173 (NR6W cells) [1] Tyr1173 (NR6wtEGFR cells) [1] Tyr992 (NR6wtEGFR cells) [1] Tyr992 (NR6W cells) [1]
26 nM 37 nM 37 nM 57 nM
体外試験

Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low-EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition. Gefitinib effectively blocks the phosphorylation of PLC-γ, with IC50 of 27nM, in NR6W cells. The NR6wtEGFR and NR6M cell lines has low levels of PLC-γ phosphorylation but the level in the NR6M cell line is more resistant to inhibition by Gefitinib with IC50 of 43 nM and 369 nM, respectively. Gefitinib inhibits Akt phosphorylations, with IC50 of 220 and 263nM, in the low-EGFR- and -EGFRvIII-expressing cell lines, respectively. Gefitinib in the dose range from 0.1 to 0.5μM significantly facilitates, rather than abrogates, colony formation of NR6M cells. However, at a concentration of 2 μM Gefitinib completely blocks NR6M colony formation. Gefitinib rapidly and in a dose-dependent manner inhibits EGFR and ERK phosphorylation up to 72 hours after EGF stimulation in both the high- and low-EGFR-expressing cell lines. [1] Gefitinib is the monolayer growth of these EGF-driven untransformed MCF10A cells with an IC50 of 20 nM. [2] The combination of Gefitinib (0.2 μM and 0.5 μM) with irradiation lead to a significant growth inhibition in LoVo cells, compared with radiation alone.. [3]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KB NH7qUFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjHXHhKSzVyPUCuNFU1KM7:TR?= NGTtcHMyPjVzNkS3Ny=>
NIH3T3 NYDxXo9bTnWwY4Tpc44hSXO|YYm= MWqwMlIh|ryP NX;EOJpjOiCq MV\EUXNQ NHPrSnJKdmirYnn0bY9vKG:oIFXHSkB{fGmvdXzheIVlKGi3bXHuJIVz[kJzIHH1eI9xcG:|cHjvdplt[XSrb36ge4l1cCCLQ{WwJI9nKDBwMEG0OEDPxE1? MmDjNVY1QDB{OES=
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A549 NVvwVHRwS3m2b4TvfIlkKEG|c3H5 NW\MV2M{QTZiaB?= NHLjbYZFVVOR MmPvTWM2OD1zMz61PUDPxE1? NHXwepYyQDNzM{iwOy=>
K562 MnvtR5l1d3SxeHnjJGF{e2G7 MX25OkBp MYnEUXNQ NEOyfWdKSzVyPUmuN|Yh|ryP M4\RbFE5OzF|OEC3
MDA-MB-231 NEfpPVJEgXSxdH;4bYMhSXO|YYm= M4nEOVk3KGh? NUDFRmF2TE2VTx?= M32yTWlEPTB;M{[uOlEh|ryP M3fke|E5OzF|OEC3
MOLT4 MXvDfZRwfG:6aXOgRZN{[Xl? NVHKNJpPQTZiaB?= MkDISG1UVw>? MmLDTWM2OD1zNT6wNkDPxE1? M1rlR|E5OzF|OEC3
MCF7 NYjs[Fl1S3m2b4TvfIlkKEG|c3H5 MXK1NEDPxE1? MVe3NkBp MoTDTWM2OD1zMj6wOUDPxE1? MmLMNVg4PzF6MUm=
BT474 MoS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\rO|IhcA>? MX\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKWNEe0JINmdGy|IH;2[ZJmgHC{ZYPzbY5oKEWUQnKyJJdqfGhiRVO1NEBw\iByLkOg{txO MmGyNVkxOjh2MkS=
HN5 NID1UIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fLPFczKGh? NULPbIl4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIUlUh[2WubIOgc5ZmemW6cILld5NqdmdiRVfGVkB4cXSqIFXDOVAhd2ZiMD6wNUDPxE1? MnXhNVkxOjh2MkS=
BA/F3 MkTVR5l1d3SxeHnjJGF{e2G7 M{PZSFczKGh? Ml\2R5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgRmEwTjNiY3XscJMh\XiycnXzd4lv\yCHR1\SJGw5PTiUIH31eIFvfCC5aYToJGlEPTBib3[gNE4xOTB6IN88US=> MofpNVkzOzl{Mkm=
NIH3T3 NEnGWmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LLcVczKGh? NWr5SpJyT3Kxd4ToJIlvcGmkaYTpc44hd2ZibX;1d4UhVkmKL{PUN{Bk\WyuczDlfJBz\XO|aX7nJIVzSjJiZ3Xu[UB4cXSqIFnDOVAhd2ZiMD61OEDPxE1? NIDzO|MyQTZ4NUO3Oy=>
MCF7 MX M3fWXmZ2dmO2aX;uJGF{e2G7 NVfBbJl{OzBibXnu MlLaTY5pcWKrdHnvckBw\iCEQ2LQJIV5eHKnc4Pl[EB4cXSqIFnDOVAhd2ZiMT6xJO69VQ>? MVWxPVk{Ojl4MB?=
A431 NVHSfo5uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;lbFExKM7:TR?= NGTkWYw4OiCq NVnzXFJ1T0l3ME2wMlUyPCEQvF2= M3vh[lE6QTZ7NE[1
A431 M3fLUGtqdmG|ZTDBd5NigQ>? M4Sy[VAvOSEQvF2= MYCxJIg> MkDyTY5pcWKrdHnvckBw\iCHR1[tbY5lfWOnZDDFS2ZTKHCqb4PwbI9zgWyjdHnvci=> NVrZPW1{OTl7Nkm0OlU>
A431 NVTze2pGU2mwYYPlJGF{e2G7 MmXYNVAxKM7:TR?= Mlr0NVAhdWmw NHHOO2ZRem:ub37n[YQhcW6qaXLpeI9zgSCjY4Tpeol1gSCxZjDFS2YucW6mdXPl[EBGT0[UIIDoc5NxcG:{eXzheIlwdg>? NWjH[VJCOTl7Nkm0OlU>
Sf9 M4KyemtqdmG|ZTDBd5NigQ>? NUnGelN7OTBibXnu NWTOW4JkTE2VTx?= MYfJcohq[mm2aX;uJI9nKEWJRmKg[ZhxemW|c3XkJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gdoVk\XC2b4KgZZV1d3Cqb4PwbI9zgWyjdHnvckB4cXSqIFnDOVAhd2ZiMD6wN|Mh|ryP M1LuVFIxODV4NEK1
NCI-H1975 M{DSdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDoZVBKPSEQvF2= NHX5SpU4OiCq NW\sUIdZUUN3ME24MlI3KM7:TR?= MmqzNlAyPTF4N{C=
NCI-H1975 NYHndYVtU2mwYYPlJGF{e2G7 MmT1NVAh|ryP MUnJcohq[mm2aX;uJI9nKEWJRmKgZZV1d3Cqb4PwbI9zgWyjdHnvci=> MonPNlAyPTF4N{C=
NCI-H1975 M164TWZ2dmO2aX;uJGF{e2G7 MW[xNEDPxE1? MVvJcohq[mm2aX;uJI9nKEWUQlKyJIF2fG:yaH;zdIhwenmuYYTpc44> NIflTmgzODF3MU[3NC=>
NCI-H1975 NEC2bnpHfW6ldHnvckBCe3OjeR?= NGX1ZWY2KM7:TR?= M{jtelQ5KGh? MnPaTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCjc4Pld5Nm\CCjczDhZ5RqfmG2aX;uJI9nKGOjc4Dhd4UuOw>? Ml;zNlAyPTF4N{C=
A375 NUHr[4U1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzTOFghcA>? NV7nSJlEUUN3ME2yNE42PSEQvF2= MkPKNlA{ODR3M{e=
SMMC7721 M3rGdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{D2VVQ5KGh? MX\JR|UxRTN|LkGyJO69VQ>? NYjEPYY5OjB|MES1N|c>
DU145 M2\uU2N6fG:2b4jpZ{BCe3OjeR?= MUm1JIQ> NXz2fWdzTE2VTx?= MkjMTWM2OD12Mj6xO{DPxE1? NHvUW|AzODR4NkW1OS=>
MIAPaCa2 NF;j[WhEgXSxdH;4bYMhSXO|YYm= M2GzVlUh\A>? NU\DfXplTE2VTx?= NUPIOVlUUUN3ME21NE43OiEQvF2= MYCyNFQ3PjV3NR?=
PANC1 NG\oU4NEgXSxdH;4bYMhSXO|YYm= M3i5UVUh\A>? NYDNWFRlTE2VTx?= NYfX[Y9kUUN3ME20NE41OiEQvF2= NIOxN4YzODR4NkW1OS=>
PC9 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIm2VmFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGVITlJvZHXmbYNq\W62IHj1cYFvKFCFOTDj[YxteyC5aYToJGVEPTBib3[gNE4xOTdizszN NVS4OZRrOjF{MEi4NFI>
PC9 NUWyVVl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHfyc5d1cC2{ZYPpd5RidnRiaIXtZY4hWEN7IHPlcIx{KGW6cILld5NqdmdiRVfGVkBGPzR4X1G3OVAwXDd7MF2gcZV1[W62IIfpeIghTUN3MDDv[kA4KM7:TR?= NVLkVXJuOjF{MEi4NFI>
PC3 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7tNVAh|ryP M{PXXFczKGh? MmTpSG1UVw>? MmrhTWM2OD15LkSg{txO M1f2R|IyOzV|NUS2
MDA-MB-468 NUPzfFJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jqTlExOCEQvF2= Mm\iOFghcA>? MnvwSG1UVw>? MnnDRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdIm= MYGyNVQzQTZ|Mh?=
Plasmodium falciparum NXXI[W0yeUiWUzDwdo9ncWyrbneg[o9zKGmwaHnibZRwenNib3[gVIxie22xZHn1cUBn[WylaYDhdpVuKHC{b3zp[oVz[XSrb36= M3;OdlIyQDF5MES1
NCI-H1993 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXLfGg4OiCq M{i3bmROW09? Mnj6TWM2OD1yLkGg{txO NU\MSnJ4OjF7MU[0N|M>
NCI-H292 NIXYb5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWi3NkBp M3HzVmROW09? NWiyW4ptUUN3ME2wMlAzKM7:TR?= MmH2NlE6OTZ2M{O=
A431 MmHUT4lv[XOnIFHzd4F6 MWSyJIg> M3XpNWROW09? MnmyTY5pcWKrdHnvckBw\iCHR1\SJJBpd3OyaH;yfYxifGmxbjDpckBGT0Zvc4TpcZVt[XSnZDDoeY1idiCDNEOxJJdqfGhiSVO1NEBw\iByLkCwNUDPxE1? NVHmRnc{OjJzMEGxN|I>
MCF7 NVL2U5ZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIX6OFkyODEEoN88[{9uVA>? MVO0PEBp MW\EUXNQ MYDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNib4\ldoV5eHKnc4PpcochTUeIUjDn[Y5mKHerdHigTWM2OCCxZjCxNk4xPSEQvF2= MV6yNlEyQTF|MB?=
BT474 Mly0R5l1d3SxeHnjJGF{e2G7 NWDRXWtCOTBizszN Ml3yOFghcA>? NGH3dZNEgXSxdH;4bYNqfHliYXfhbY5{fCC|ZYL1cU1{fGG{dnXkJIh2dWGwIFLUOFc1KGOnbHzz MXKyNlE{QDNyOB?=
MCF7 NGq4e21EgXSxdH;4bYMhSXO|YYm= MkDnNVAh|ryP MWi0PEBp NHLKOXZEgXSxdH;4bYNqfHliYXfhbY5{fCC|ZYL1cU1{fGG{dnXkJIh2dWGwIF3DSlch[2WubIOgc5Zmei2neIDy[ZN{cW6pIFXyZmIzKGOnbHzz Ml25NlIyOzh|MEi=
HCC827 M3nBb2tqdmG|ZTDBd5NigQ>? MV[wMlEzPSEQvF2= M1:3elI1KGh? NX7jXWlxTE2VTx?= MmrxTY5pcWKrdHnvckBw\iCHR1\SJIRmdCCHN{S2MWE4PTBibYX0ZY51KFlzME[4JIF2fG:yaH;zdIhwenmuYYTpc44> NIXZ[lQzOjN|OUO0Ni=>
HCC827 Mlj4T4lv[XOnIFHzd4F6 M1LZO|AvOTJ3IN88US=> NI[5NZAzPCCq MVfEUXNQ M3XqV2lvcGmkaYTpc44hd2ZiRVfGVkBl\WxiRUe0Ok1CPzVyIH31eIFvfC2vZXTpZZRm\CCHcnugdIhwe3Cqb4L5cIF1cW:w NWL1[mdXOjJ|M{mzOFI>
HCC827 MVHLbY5ie2ViQYPzZZk> NIjnWoMxNjF{NTFOwG0> MojVNlQhcA>? MortSG1UVw>? M3PXS2lvcGmkaYTpc44hd2ZiRVfGVkBl\WxiRUe0Ok1CPzVyIH31eIFvfC2vZXTpZZRm\CCDa4SgdIhwe3Cqb4L5cIF1cW:w NELPU2EzOjN|OUO0Ni=>
A431 NVjkOVVZU2mwYYPlJGF{e2G7 NFPFT2MyODBizszN MWmzNEBucW5? MnLFTY5pcWKrdHnvckBw\iCHR1\SJIRmemm4ZXSg[pJwdSCqdX3hckBCPDNzIHPlcIwhdWWvYoLhcoUh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBxd2y7LVfseU1VgXJicHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCxMlA5KM7:TR?= M{Dzd|IzPjl6N{iy
H460 MUjDfZRwfG:6aXOgRZN{[Xl? NHvvT|c4OiCq NEW2flhKSzVyPUWuOVkh|ryP MkjTNlI4Ojd2NEm=
HT-29 M370ZmN6fG:2b4jpZ{BCe3OjeR?= NVPhWoFJPzJiaB?= M1\SfmlEPTB;Mz6zOkDPxE1? MWKyNlczPzR2OR?=
SGC7901 NV3JZZZoS3m2b4TvfIlkKEG|c3H5 NX76NnRQPzJiaB?= Mm\XTWM2OD1zMD6yOkDPxE1? MXiyNlczPzR2OR?=
A498 NYHuTVlVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXy0NohUSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOFk5KGOnbHzzJIV5eHKnc4PpcochTUeIUjDhcoQhW1KFIIfpeIghUUN3MDDv[kA5NjZizszN NIq3bJQzOjhzOEi0PC=>
Calu3 M2C1OWN6fG:2b4jpZ{BCe3OjeR?= MVOxNEDPxGdxbVy= NIXDXXM4OiCq MnPVTWM2OD1zLk[g{txO NW\OflNCOjNzMU[xOlg>
FADU NY\wXJVPS3m2b4TvfIlkKEG|c3H5 MX:xNEDPxGdxbVy= MlzJO|IhcA>? MUnJR|UxRTBwMEWg{txO Mn3HNlMyOTZzNki=
HCC827 MXHDfZRwfG:6aXOgRZN{[Xl? NYjs[IRmOTBizsznM41N MofDO|IhcA>? NGrVOZhKSzVyPUCuNFAyPSEQvF2= MWqyN|EyPjF4OB?=
PC9 M2[1[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUKxNEDPxGdxbVy= M3nuNVczKGh? MXPJR|UxRTBwMECxOEDPxE1? NG\BV|YzOzFzNkG2PC=>
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JVM-3 M4LmN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2roS2lEPTB;Mj6zOFY1OyEQvF2= MUXTRW5ITVJ?
NCI-H2170 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTJwM{S3PFMh|ryP MYnTRW5ITVJ?
EW-18 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmj1TWM2OD1{LkO1OFcyKM7:TR?= MlTXV2FPT0WU
KU812 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnPTWM2OD1{LkO2O|c6KM7:TR?= MUXTRW5ITVJ?
NY MlHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTJwM{eyO{DPxE1? M3zseXNCVkeHUh?=
HTC-C3 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfCVpVMUUN3ME2yMlQzOjZ5IN88US=> MlW2V2FPT0WU
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HH MnXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTJwNEm4OVQh|ryP M2TvSHNCVkeHUh?=
MKN7 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;IbpBrUUN3ME2yMlYzPzR6IN88US=> MoS0V2FPT0WU
TE-8 M1y5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrOc5BsUUN3ME2yMlY{PjV|IN88US=> M4K5XHNCVkeHUh?=
MC-IXC NVviRWFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrs[lFKSzVyPUKuOlQ1PTNizszN NH3aUYVUSU6JRWK=
DMS-79 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkX6TWM2OD1{Lk[5Nlg1KM7:TR?= MWPTRW5ITVJ?
Detroit562 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTJwNkm4OFUh|ryP MkjXV2FPT0WU
HuP-T4 NF\Ce29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUi4VldRUUN3ME2yMlczQDF6IN88US=> NF\FOZhUSU6JRWK=
QIMR-WIL M2f0Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;qfWlEPTB;Mj63OVk2OiEQvF2= MmfrV2FPT0WU
BB65-RCC MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLoW282UUN3ME2yMlgxPzF|IN88US=> MWHTRW5ITVJ?
PC-3 NVXaZmY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXH[WRCUUN3ME2yMlg{OzF5IN88US=> Mlr2V2FPT0WU
OVCAR-3 NIK0[GFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTJwOEW1PVQh|ryP MnT6V2FPT0WU
KYSE-510 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\HfopKSzVyPUKuPFY4QDZizszN M4PoWXNCVkeHUh?=
HC-1 Ml7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHsbWxKSzVyPUKuPVQxOTJizszN NVHo[Ys6W0GQR1XS
NCI-H1693 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7PUoJKSzVyPUKuPVU5QTdizszN NWrUW3R2W0GQR1XS
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MN-60 NGDEZ|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3e0cGlEPTB;Mz6wOFk4PCEQvF2= MXjTRW5ITVJ?
BCPAP MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHr1N3lKSzVyPUOuNFgzQTVizszN MVnTRW5ITVJ?
647-V MmfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTNwMU[yNkDPxE1? MX3TRW5ITVJ?
HT-1376 NXLvc3pXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTNwMkC1NFYh|ryP M3fVWHNCVkeHUh?=
NCI-H1793 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3HTWM2OD1|LkKxNFk5KM7:TR?= NUf1[oRzW0GQR1XS
SW1463 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mle4TWM2OD1|LkK2NVkzKM7:TR?= NVrocVM3W0GQR1XS
NCI-H727 NHzvSpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWr1TVNEUUN3ME2zMlM5PTh2IN88US=> NYLVRYEzW0GQR1XS
LB771-HNC NHXVNWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTNwM{mxNlYh|ryP MnfDV2FPT0WU
D-542MG MknSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TxSGlEPTB;Mz60OFIzOiEQvF2= MWjTRW5ITVJ?
NTERA-S-cl-D1 MmHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\JTWM2OD1|LkS0PVU4KM7:TR?= NIe5cplUSU6JRWK=
C8166 NV7vdY0{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfOTWM2OD1|LkS2OVIyKM7:TR?= M3TFVnNCVkeHUh?=
639-V NGf4T|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LBVGlEPTB;Mz61O|c6OiEQvF2= NIf4cG1USU6JRWK=
TE-1 M2Gwcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTCcnJKSzVyPUOuOVkyPjlizszN NUDISZJVW0GQR1XS
OAW-28 NHzKcG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\VTWM2OD1|LkW5OFI3KM7:TR?= MUXTRW5ITVJ?
SK-LU-1 NXzLNotET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUD2d5FpUUN3ME2zMlYxPjR3IN88US=> NULERZo1W0GQR1XS
CaR-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTNwNkGwOFgh|ryP NHHYcG5USU6JRWK=
A2780 MofGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTz[pJ4UUN3ME2zMlY1ODh7IN88US=> NXfKVFQxW0GQR1XS
C2BBe1 MkntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnP2TWM2OD1|Lk[0OFA4KM7:TR?= MoqyV2FPT0WU
SK-MES-1 NFvQcWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYraOWJ2UUN3ME2zMlY1PjF2IN88US=> MV;TRW5ITVJ?
PANC-10-05 NHfEbmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETpNGNKSzVyPUOuO|IxPzJizszN MlzmV2FPT0WU
J-RT3-T3-5 MmHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfBS41xUUN3ME2zMlc2PDB4IN88US=> NXfpfnRWW0GQR1XS
ES4 M{[4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3W3TmlEPTB;Mz64NlI5PiEQvF2= M2XqfHNCVkeHUh?=
NCI-H28 NFSy[4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFuycFFKSzVyPUOuPFI6PjFizszN M4XzWHNCVkeHUh?=
NCI-H1155 NI\OWIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTNwOESxOVkh|ryP MUDTRW5ITVJ?
KURAMOCHI NHrMW2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfPTWM2OD1|Lki2NFU3KM7:TR?= Mn;GV2FPT0WU
NCI-H69 NWTkbVk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTNwOUCxO|gh|ryP NYPrclJXW0GQR1XS
IST-MES1 MlniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LGUGlEPTB;Mz65OFAzQSEQvF2= M2i3dHNCVkeHUh?=
NH-12 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlP1TWM2OD1|Lkm0NVg4KM7:TR?= NUj1UWZ3W0GQR1XS
JVM-2 NELnZo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIW2blJKSzVyPUOuPVQ4PTJizszN NEDOSGxUSU6JRWK=
EW-16 NYTDVYxYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLTOYRKSzVyPUOuPVU2PzdizszN NWHENnlFW0GQR1XS
NCI-H441 MmjZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTleZpxUUN3ME2zMlk4ODF2IN88US=> M4Xmd3NCVkeHUh?=
RCC10RGB Ml3CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzETWM2OD12LkCxNlQ3KM7:TR?= MWnTRW5ITVJ?
TCCSUP MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTse2pKSzVyPUSuNVExPSEQvF2= Mm\mV2FPT0WU
HL-60 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnaR4RKSzVyPUSuNVIzPDFizszN MlPJV2FPT0WU
EW-11 NH3PU2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfUdIhKSzVyPUSuNVMzPjFizszN M1fnd3NCVkeHUh?=
KARPAS-299 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHuU4NKSzVyPUSuN|ExOTNizszN M{jZTHNCVkeHUh?=
SNU-C2B NWHZTXM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrvTWM2OD12LkO0Olg3KM7:TR?= M{TnUnNCVkeHUh?=
LU-139 NYDNfYdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\RNoZKSzVyPUSuN|czPDdizszN NVXZcnNnW0GQR1XS
HCC1937 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjkRphEUUN3ME20MlM4QTl|IN88US=> NF\TTYFUSU6JRWK=
GR-ST MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVK3PWFSUUN3ME20MlQ{OThizszN MkHEV2FPT0WU
SK-OV-3 NFfTXHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfXXYFVUUN3ME20MlQ3ODR{IN88US=> NWLt[GQ{W0GQR1XS
A172 M2O4WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF:wNHFKSzVyPUSuOVU2OjFizszN MUHTRW5ITVJ?
NB10 M4PNbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPH[XhKSzVyPUSuOVk4QDFizszN NHnlbHhUSU6JRWK=
P30-OHK NFHScWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVL1flh1UUN3ME20MlgyQTJ7IN88US=> NGfifGNUSU6JRWK=
KYSE-520 NUS1bYpyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfFbndGUUN3ME20Mlg5ODF6IN88US=> MWLTRW5ITVJ?
KNS-62 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTRwOUC4NFch|ryP MmTaV2FPT0WU
ES1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nHfWlEPTB;ND65OlA{PSEQvF2= NY\GepZ2W0GQR1XS
KOSC-2 M3q1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlixTWM2OD12Lkm5PVU6KM7:TR?= NIfMfIxUSU6JRWK=
TE-9 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEKwUlNKSzVyPUWuNFE2OjVizszN M{nHPHNCVkeHUh?=
NCI-H1838 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTVwMEKwO|Yh|ryP NH3JOnpUSU6JRWK=
KP-N-YN MoDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1no[2lEPTB;NT6xNlU6OSEQvF2= MlXIV2FPT0WU
ALL-PO NIfUUWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnXUHpoUUN3ME21MlIzPTh5IN88US=> MkXHV2FPT0WU
NOMO-1 M{PpOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfSSI9KSzVyPUWuNlMyPzZizszN MYrTRW5ITVJ?
CGTH-W-1 NU\vdYhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDOTWM2OD13LkO4OVg1KM7:TR?= NUm5V|ZFW0GQR1XS
ATN-1 M1raXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrrfnNKSzVyPUWuOFEyQDRizszN NF31W4VUSU6JRWK=
AGS M2f2fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnKzTWM2OD13LkS5OlE5KM7:TR?= M3fRcnNCVkeHUh?=
SW13 NIfEZ3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\5dGlEPTB;NT61N|I3PSEQvF2= MmDZV2FPT0WU
SW1990 NY\MToFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorsTWM2OD13Lk[yNlg2KM7:TR?= M4PWS3NCVkeHUh?=
BFTC-905 NITEWnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2f5dmlEPTB;NT62OVg4QCEQvF2= NED5OJdUSU6JRWK=
RMG-I NUnhPWlST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TZdmlEPTB;NT62OVk1OiEQvF2= NFXGeWxUSU6JRWK=
HD-MY-Z NFf3dFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfzTWM2OD13Lk[4OVgyKM7:TR?= NUn6TVZEW0GQR1XS
HCC1187 NELSVFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnRdYlKSzVyPUWuO|ExOzJizszN Ml7OV2FPT0WU
HCC2998 M2PHdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYmwdnc3UUN3ME21MlcyQDd5IN88US=> MVvTRW5ITVJ?
RT-112 NVfS[lZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\mTWM2OD13LkmwNlQ2KM7:TR?= MoP5V2FPT0WU
CAKI-1 NWf5O3VTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LxSGlEPTB;Nj6wNFk5PSEQvF2= MVfTRW5ITVJ?
HDLM-2 M{Ty[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\xflhSUUN3ME22MlAyPDh7IN88US=> NG\HWY5USU6JRWK=
TE-10 NIe5R5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XxcGlEPTB;Nj6wOFg{OyEQvF2= NFztepRUSU6JRWK=
KE-37 NEnrXHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\KfXh{UUN3ME22MlA4OjV6IN88US=> M4\5fHNCVkeHUh?=
RCM-1 NI\wTHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLIcnBwUUN3ME22MlA4PzF7IN88US=> NX\Tc2lVW0GQR1XS
Mewo NH7vbY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonlTWM2OD14LkGxOFg4KM7:TR?= M1fUdXNCVkeHUh?=
L-428 M{fFXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTZwMUiwN|ch|ryP Mle4V2FPT0WU
8-MG-BA MoexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPhTWM2OD14LkG5N|c6KM7:TR?= NWHMbYtQW0GQR1XS
SK-MEL-28 NUjNRnhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLsdpJKSzVyPU[uNlA6PjdizszN M3\uNXNCVkeHUh?=
VA-ES-BJ MofjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTZwM{C0OlIh|ryP M1HldXNCVkeHUh?=
CAL-120 NFS2RXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnztTWM2OD14LkS1NVYzKM7:TR?= NILSVphUSU6JRWK=
GAMG NFnQWVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIqzVHJKSzVyPU[uOVA3OiEQvF2= MoPOV2FPT0WU
MSTO-221H M1LDRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zyeWlEPTB;Nj61NVE4KM7:TR?= M3[xcXNCVkeHUh?=
GCT MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHpU|doUUN3ME22MlU{Ozh5IN88US=> NGi1b4VUSU6JRWK=
SH-4 M2DUXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rNfmlEPTB;Nj61PFg1PCEQvF2= MVXTRW5ITVJ?
Calu-3 NFrVe5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7VXVVKSzVyPU[uOlU2PjhizszN Mor2V2FPT0WU
SK-HEP-1 NWrLfZJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXe2Nm9uUUN3ME22MlcyPzV|IN88US=> MVHTRW5ITVJ?
PFSK-1 NIDVbVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTETWM2OD14LkezOFc5KM7:TR?= MnrmV2FPT0WU
NB12 MkD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUS1dZVxUUN3ME22Mlc5PDB2IN88US=> NEjUNo5USU6JRWK=
A388 NUPQVoZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfmTWM2OD14Lki5OVIh|ryP NESxTlBUSU6JRWK=
KLE MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrFN3pwUUN3ME22Mlk3PTF4IN88US=> NVK4d5BtW0GQR1XS
TE-11 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jJSmlEPTB;Nz6wOFk3PyEQvF2= MkjoV2FPT0WU
NCI-H2405 NWjzbHNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XpXGlEPTB;Nz6wPFM6OyEQvF2= NWjzSGJRW0GQR1XS
OVCAR-4 NHvRNHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTdwMUWzOUDPxE1? NYf4PGRzW0GQR1XS
KP-N-YS NEXMWpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrmUG1KSzVyPUeuNVgyPCEQvF2= M1nnO3NCVkeHUh?=
NOS-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\RTWM2OD15LkK1PFI5KM7:TR?= MXPTRW5ITVJ?
DMS-114 MnrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLNNGVpUUN3ME23MlI6PjNzIN88US=> Mn;PV2FPT0WU
NCI-H2030 MoftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4e5Z2lEPTB;Nz6zN|Y6QCEQvF2= NUHYbWNYW0GQR1XS
HEL Ml;PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TOOmlEPTB;Nz6zO|UzOSEQvF2= M2r0dXNCVkeHUh?=
CAL-62 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTdwM{m4OlYh|ryP MXnTRW5ITVJ?
COLO-668 NXvqT5NlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonPTWM2OD15LkSzPVY4KM7:TR?= NW\ucnBuW0GQR1XS
SKG-IIIa M1\jTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrzTWM2OD15LkS1N|gyKM7:TR?= MoPlV2FPT0WU
HCC1419 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfFbWJKSzVyPUeuOFY5OzNizszN NELmSGtUSU6JRWK=
OS-RC-2 M4H1emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHaTWM2OD15LkS5PFk1KM7:TR?= NXfEWIFJW0GQR1XS
COLO-829 M3TDT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTdwNk[0OlMh|ryP NIK0Z4NUSU6JRWK=
NB13 NFLRbJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHP2WWJKSzVyPUeuPFI3PjdizszN NYP1NIl2W0GQR1XS
DK-MG MnjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHTNWNZUUN3ME23Mlg{OjBzIN88US=> MYDTRW5ITVJ?
SHP-77 M3f2XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTdwOE[2OVMh|ryP NYfoRVNUW0GQR1XS
NCI-H661 MmfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjxem1nUUN3ME24MlA2QDZ5IN88US=> M{LDZXNCVkeHUh?=
AM-38 MlXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRThwMU[yPEDPxE1? NFnweJlUSU6JRWK=
VM-CUB-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVruVWZSUUN3ME24MlE4ODJ7IN88US=> M{fkWXNCVkeHUh?=
KYSE-70 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTQbIVKSzVyPUiuNVk4PjFizszN NF7PTGJUSU6JRWK=
5637 Mkn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml:zTWM2OD16LkOxNFU2KM7:TR?= M3LqeXNCVkeHUh?=
TGBC11TKB MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjZO49lUUN3ME24MlQ3OTZ2IN88US=> NIPRXYpUSU6JRWK=
EGI-1 MonPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLiSo1EUUN3ME24MlYxODh6IN88US=> NVrxPYN{W0GQR1XS
D-392MG M33kbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NES4TpVKSzVyPUiuOlYzOTRizszN MUjTRW5ITVJ?
A673 NU\qcHNRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvGTWM2OD16Lk[3OlEyKM7:TR?= M{LpNXNCVkeHUh?=
COLO-792 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHWTW1RUUN3ME24Mlc1QTR4IN88US=> NVzCTIx4W0GQR1XS
NCI-H1792 M1X4[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYi0S4h4UUN3ME24Mlg5QTB|IN88US=> Mn[3V2FPT0WU
LS-1034 M{fCU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWD2WINVUUN3ME24Mlk1PjV{IN88US=> Ml3FV2FPT0WU
D-566MG NFm4[3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTlwMEG4NUDPxE1? MmnBV2FPT0WU
NCI-H226 M2DDfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTlwMEmg{txO MkjPV2FPT0WU
ChaGo-K-1 MlnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PERWlEPTB;OT6xNFU4QSEQvF2= M3naW3NCVkeHUh?=
NCI-H2228 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTlwMUGwPFEh|ryP NXXwS2x5W0GQR1XS
RPMI-8226 NH3ZXFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmn0TWM2OD17LkGxN|A1KM7:TR?= NFjpRWNUSU6JRWK=
BFTC-909 NXzld4E3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTlwMUiyPVch|ryP MmniV2FPT0WU
HPAF-II MkPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTlwMkK1NVgh|ryP M4jpSXNCVkeHUh?=
Capan-2 NGW1WnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoW2TWM2OD17LkSwNVA6KM7:TR?= NWS0WYhFW0GQR1XS
IA-LM MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTlwNEG5OlYh|ryP NWHtVY5NW0GQR1XS
KP-4 Ml7jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2K2UWlEPTB;OT60PFg{QCEQvF2= NYG3S2doW0GQR1XS
A101D NEDUfFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTlwNUG3NVkh|ryP NHnGW5hUSU6JRWK=
EFO-21 MnrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PBSmlEPTB;OT61PFc{PSEQvF2= M{G2SHNCVkeHUh?=
C32 NFfRTFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjSWmZpUUN3ME25MlY{OzRizszN NWHpTo9EW0GQR1XS
SW837 NH7LVXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PISWlEPTB;OT64OFgzKM7:TR?= NITie2pUSU6JRWK=
OCI-AML2 NFX6ZoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\JWoxnUUN3ME25Mlg3QTZizszN M{HoNXNCVkeHUh?=
NCI-H1355 MkD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PZcmlEPTB;OT65OFA5QCEQvF2= M4r3VnNCVkeHUh?=
NCI-H2342 NX25Z4FMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\qUGlEPTB;MUCuNFE2PSEQvF2= MlrKV2FPT0WU
A204 NHm1O25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnKyTWM2OD1zMD6wOFY3KM7:TR?= M33nTnNCVkeHUh?=
CAL-51 MnTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3SzfWlEPTB;MUCuNFg4PyEQvF2= M2j3UnNCVkeHUh?=
HCE-4 NUjTTndsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGK1TVJKSzVyPUGwMlEyOjJizszN M1\DNHNCVkeHUh?=
NCI-H810 NYrPSJdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnGTWM2OD1zMD6xOVk4KM7:TR?= M4DWWXNCVkeHUh?=
DJM-1 M2O1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrpTWM2OD1zMD6xO|MzKM7:TR?= MVjTRW5ITVJ?
SK-UT-1 NGG4SHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\3WGlEPTB;MUCuNlU4PCEQvF2= M1TDSHNCVkeHUh?=
U031 MlLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIe3SHVKSzVyPUGwMlI3QDZizszN MlTLV2FPT0WU
YH-13 NXHKbINWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XDU2lEPTB;MUCuN|A2PyEQvF2= M3\mfHNCVkeHUh?=
K5 NHS5XJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTxTWM2OD1zMD6zN|k2KM7:TR?= M4m2cXNCVkeHUh?=
HEC-1 NHTwN5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGC4UIRKSzVyPUGwMlQxQDFizszN NYO0XWJ2W0GQR1XS
A2058 NFX6Nm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPGd4lZUUN3ME2xNE42PDlzIN88US=> NYWyPFl1W0GQR1XS
SW962 NVraZlVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\mfmlEPTB;MUCuOlIxPCEQvF2= MmrTV2FPT0WU
VMRC-RCZ M3j4Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVK1N21zUUN3ME2xNE43PzR7IN88US=> M2\vUXNCVkeHUh?=
D-336MG MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\5TWM2OD1zMD63NFA2KM7:TR?= Ml\JV2FPT0WU
LXF-289 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3i3dmlEPTB;MUCuO|k3PyEQvF2= M3n0fnNCVkeHUh?=
SW900 NXvLPJNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfjeWRKSzVyPUGwMlgzOjhizszN NIL6c4JUSU6JRWK=
K-562 M3O5bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;udGVKSzVyPUGwMlg{QTVizszN MnjwV2FPT0WU
HCC38 M1G4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3uzfGlEPTB;MUCuPVcyPiEQvF2= Mn;IV2FPT0WU
SF-295 MoTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPSV2VKUUN3ME2xNE46QTB{IN88US=> MUPTRW5ITVJ?
LB831-BLC MnrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7n[5VKSzVyPUGxMlI2PTZizszN NV31c5BXW0GQR1XS
FTC-133 NHT5WXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHlNm1KSzVyPUGxMlMxQDFizszN MVHTRW5ITVJ?
HCC1954 NYj3eoJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTFzLkSzOkDPxE1? Mo\YV2FPT0WU
GOTO NID6VmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2n3fGlEPTB;MUGuOVIxPiEQvF2= M4DOVXNCVkeHUh?=
LS-411N M2XGS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrh[VF5UUN3ME2xNU43OTBzIN88US=> Mn64V2FPT0WU
RPMI-7951 NWnzcVR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTFzLk[zOFgh|ryP MnXkV2FPT0WU
NCI-H1299 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDCPZJrUUN3ME2xNU43PjR5IN88US=> M4CweXNCVkeHUh?=
MLMA MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjETWM2OD1zMT62PVk4KM7:TR?= NGD3bZJUSU6JRWK=
MMAC-SF MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3OZoVKSzVyPUGxMlczPTJizszN MUnTRW5ITVJ?
UM-UC-3 M2joXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXySYxTUUN3ME2xNU44PDJzIN88US=> NWrXTIJqW0GQR1XS
SCC-9 Mln1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLkXlAxUUN3ME2xNU45OTVzIN88US=> M4DFN3NCVkeHUh?=
HOS MljwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnn3TWM2OD1zMT64Olg{KM7:TR?= MVXTRW5ITVJ?
OE19 MkjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTIfItpUUN3ME2xNU46OzZ5IN88US=> NWTZTItpW0GQR1XS
Mo-T NFnKXIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTFzLkm1OFEh|ryP M2PnUXNCVkeHUh?=
CAMA-1 NIHkXmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXPV5FKSzVyPUGyMlE3OzNizszN NIeyXodUSU6JRWK=
U-118-MG M4LwVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2D6fWlEPTB;MUKuNlQ1OSEQvF2= M2mxeXNCVkeHUh?=
KS-1 NVTsSVVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2ToR2lEPTB;MUKuNlg{OiEQvF2= MWDTRW5ITVJ?
JAR NU\pbZpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2q0W2lEPTB;MUKuN|M3QSEQvF2= Mn\xV2FPT0WU
ABC-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1frZmlEPTB;MUKuN|QyKM7:TR?= MXzTRW5ITVJ?
Daoy M37yUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLKT4g1UUN3ME2xNk41PTR{IN88US=> M2jMfnNCVkeHUh?=
C3A NUXhOWpIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTZdJpKSzVyPUGyMlU4QDVizszN NXzhcop1W0GQR1XS
GT3TKB M4i1VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXjXXpKSzVyPUGyMlY{OjdizszN NF20flZUSU6JRWK=
DMS-273 M3qw[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;I[XROUUN3ME2xNk45PjN|IN88US=> NV:3RXRqW0GQR1XS
G-361 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXzTWM2OD1zMj65NVI6KM7:TR?= MYfTRW5ITVJ?
RH-18 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrqTWM2OD1zMz6yPVYzKM7:TR?= NHPUUVFUSU6JRWK=
SN12C MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTF|LkO4NFgh|ryP M4n2ZXNCVkeHUh?=
NCI-H1993 NYPPc4ZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rIbmlEPTB;MUOuOFI5PSEQvF2= NFrLXnpUSU6JRWK=
LOXIMVI NUXuUZRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnIXIRbUUN3ME2xN{43OTVzIN88US=> MkX4V2FPT0WU
SK-PN-DW MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTF|Lki0Nlch|ryP M1H6cHNCVkeHUh?=
KALS-1 MlPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PPemlEPTB;MUOuPFUzPSEQvF2= MmPVV2FPT0WU
LAN-6 NHLIcoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzUSZNZUUN3ME2xOE4zPTNizszN MXPTRW5ITVJ?
A549 MlPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nBPWlEPTB;MUSuOFcyOiEQvF2= NVPBbnpTW0GQR1XS
RD NUjmcYhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTF2LkS4NVMh|ryP NEfLZ3lUSU6JRWK=
TGBC1TKB NIXuO21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzMTWM2OD1zND62OlE2KM7:TR?= NWDaWXZzW0GQR1XS
NCI-H630 Ml61S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnyTWM2OD1zND65OFY4KM7:TR?= NUT2c3QxW0GQR1XS
MIA-PaCa-2 NXP6SGpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDtXFNKSzVyPUG0Mlk3QSEQvF2= MXzTRW5ITVJ?
NCI-H1755 MkjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrOTWM2OD1zND65PVU{KM7:TR?= NUXDN4tYW0GQR1XS
MOLT-4 MnPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHHdIFKSzVyPUG1MlA1QTdizszN NH7PfpRUSU6JRWK=
CW-2 M3j3R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HtRmlEPTB;MUWuNVQzOSEQvF2= MmH0V2FPT0WU
COLO-320-HSR NVzCT5ZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XxRmlEPTB;MUWuOVMxPyEQvF2= NIfsfWFUSU6JRWK=
UMC-11 MlXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4[yUWlEPTB;MUWuO|UzOyEQvF2= Ml61V2FPT0WU
MCF7 NWHmcWV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVmyeW1GUUN3ME2xOU45OTR3IN88US=> MV\TRW5ITVJ?
NCI-H23 M37OeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPMTWM2OD1zNT64OFM5KM7:TR?= M{LGdnNCVkeHUh?=
HuCCT1 NHLoRY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH62dm9KSzVyPUG1Mlg4PCEQvF2= M4jw[HNCVkeHUh?=
MPP-89 M{i3XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTF3Lkm0NVch|ryP M1rPRnNCVkeHUh?=
HT55 MlvBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37WbmlEPTB;MUWuPVQ4QCEQvF2= M1\GZ3NCVkeHUh?=
no-11 NEfhS5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HKZ2lEPTB;MUWuPVY3OyEQvF2= NVHP[|NIW0GQR1XS
GP5d MkPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHFd2FKSzVyPUG2MlIyQDdizszN M1fCcHNCVkeHUh?=
BHT-101 MoHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTF4LkK0N|kh|ryP NIPtSnNUSU6JRWK=
M059J NETRNmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTF4LkK4OEDPxE1? MnyyV2FPT0WU
D-283MED M2rM[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU[5WVl4UUN3ME2xOk41OjB7IN88US=> MUjTRW5ITVJ?
BEN NX\vS4ZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnyTYpxUUN3ME2xOk42OTV3IN88US=> M4L0UHNCVkeHUh?=
LB373-MEL-D MkLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\rTWM2OD1zNj63NlMzKM7:TR?= MoHTV2FPT0WU
MEL-HO NYjL[5drT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvzfYZWUUN3ME2xOk45QDV2IN88US=> MWPTRW5ITVJ?
GI-ME-N M2S3cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYP2RnZsUUN3ME2xOk46ODN{IN88US=> M4nQOnNCVkeHUh?=
RKO NWHDOpVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rHZ2lEPTB;MUeuNFc1QCEQvF2= MnLHV2FPT0WU
MZ2-MEL MojqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXPTWM2OD1zNz6xN|Mh|ryP MV3TRW5ITVJ?
NCI-H1573 M3rLO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1T5SGlEPTB;MUeuNlgzPiEQvF2= NIfObo1USU6JRWK=
NCI-H1581 M4HmPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moq3TWM2OD1zNz60OFEyKM7:TR?= M2izd3NCVkeHUh?=
NCI-H747 NU\uWlRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rUb2lEPTB;MUeuOVI6PyEQvF2= MlO4V2FPT0WU
SW1783 NX70XWN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHsO|NxUUN3ME2xO{43PDF3IN88US=> NVjXbHU4W0GQR1XS
Calu-6 MoT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHrZZdKSzVyPUG3MlY4QDJizszN M2P1S3NCVkeHUh?=
SF268 M4jMUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;4XlZKSzVyPUG3MlY6PjlizszN NHzKUm9USU6JRWK=
ES8 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrCTG5ZUUN3ME2xO{45PTl|IN88US=> MYjTRW5ITVJ?
KM-H2 NIHPUotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVWxdXRPUUN3ME2xO{46PDFzIN88US=> MoTZV2FPT0WU
D-502MG Ml\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnObndPUUN3ME2xO{46QDB6IN88US=> NYD0d4ZGW0GQR1XS
HLE MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTrTWM2OD1zOD6zNVQ5KM7:TR?= NVe3[JlpW0GQR1XS
SW982 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLaNHk6UUN3ME2xPE41ODd3IN88US=> M3jvfHNCVkeHUh?=
MDA-MB-361 NUXI[HkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3HWo9KSzVyPUG4MlU2QDhizszN Mon2V2FPT0WU
NCI-H1563 M2fOZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnP6TWM2OD1zOD63NVI1KM7:TR?= NWnXeGllW0GQR1XS
MFE-280 NX62WGd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTF6LkeyPVMh|ryP NVzXSZdnW0GQR1XS
U251 NF7QcY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnxTWM2OD1zOD63N|Q4KM7:TR?= MX3TRW5ITVJ?
KNS-42 NITWdmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37jeWlEPTB;MUiuPFAyPSEQvF2= MWfTRW5ITVJ?
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NB14 MoL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTN6LkS1OFQh|ryP M{TtPXNCVkeHUh?=
D-423MG MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXn1TGZlUUN3ME2zPE41QDZ7IN88US=> NEHUT4lUSU6JRWK=
NCI-H510A MonpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;OfGN3UUN3ME2zPE43PDVzIN88US=> NYTqfnJJW0GQR1XS
NMC-G1 MnHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjYemNvUUN3ME2zPE44OjJ{IN88US=> MUnTRW5ITVJ?
SW948 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrHTWM2OD1|OD64PVQ6KM7:TR?= MkLKV2FPT0WU
MFM-223 NGK3VIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTyRVY1UUN3ME2zPE46PDNzIN88US=> M1XTZ3NCVkeHUh?=
PAN1 NYLvRVVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfVWmxzUUN3ME2zPE46QTF7IN88US=> Ml;wV2FPT0WU
MZ7-mel M{TySmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLCTWM2OD1|OT6xNVk6KM7:TR?= MXfTRW5ITVJ?
COLO-679 NI\5[pRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPXfINKSzVyPUO5Mlk4ODhizszN M1Ln[nNCVkeHUh?=
SW872 M1u4cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTRyLkKwN|Eh|ryP MXrTRW5ITVJ?
HT-1197 M2rjTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vocGlEPTB;NECuNlg3QSEQvF2= MonLV2FPT0WU
ES6 Mk\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnr0TWM2OD12MD60OVUzKM7:TR?= NV7wNVJKW0GQR1XS
SNU-387 M4W0UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIn5R4NKSzVyPUSwMlgzOzhizszN NW\OeW11W0GQR1XS
T47D NHHvZ3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoOwTWM2OD12MT6wNVkzKM7:TR?= NWS2TYNjW0GQR1XS
G-402 NELtVXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTRzLkC4NFkh|ryP NEnje2VUSU6JRWK=
MZ1-PC MnXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnRTnJ1UUN3ME20NU45OSEQvF2= NWHkcGZbW0GQR1XS
SW1417 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk[0TWM2OD12Mj6zNFMh|ryP MWjTRW5ITVJ?
RERF-LC-MS NEPVPYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTZTWM2OD12Mj61NFg4KM7:TR?= MlnyV2FPT0WU
SF539 NXrRS2hkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjKRVNKSzVyPUSyMlU2OjlizszN MkTKV2FPT0WU
ESS-1 M{LSZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYflVG9{UUN3ME20N{42PTV6IN88US=> MYfTRW5ITVJ?
RO82-W-1 M{myOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTR|Lk[xOVMh|ryP M1P2cHNCVkeHUh?=
S-117 M2PFc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHtRZFKSzVyPUSzMlY6PThizszN NWGwZ2d[W0GQR1XS
SW756 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTR|LkiyOFIh|ryP MX\TRW5ITVJ?
CP66-MEL NV3ZWopWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFi5To9KSzVyPUS1MlcyPDNizszN MWPTRW5ITVJ?
H-EMC-SS MnLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTR3Lke2PVMh|ryP MVvTRW5ITVJ?
NCI-H2052 M4X4fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHj4cpVKSzVyPUS1MlkxOjdizszN MkO3V2FPT0WU
SW684 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTR5LkCwPFEh|ryP NU[ybmpGW0GQR1XS
HCC1569 NHnFV4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTR5LkG2OVgh|ryP MXLTRW5ITVJ?
KGN M3vF[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXS1SoVEUUN3ME20O{4{OzFzIN88US=> M2\KSnNCVkeHUh?=
LCLC-103H M3\QVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTR5LkS0NFQh|ryP MmD5V2FPT0WU
SW780 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTR5Lk[zOVEh|ryP MUjTRW5ITVJ?
NCI-H1703 NEXsOlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrRWopUUUN3ME20PE4{OzV{IN88US=> MWnTRW5ITVJ?
HCC1395 MkK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13wcGlEPTB;NEiuO|Q{OiEQvF2= NWi5cZlSW0GQR1XS

多くの細胞株試験データを見る場合、クリックしてください

体内試験 Gefitinib (100 mg/kg) improves the anti-tumor effect of radiotherapy in LoVo tumor xenografts. [3] Gefitinib treatment of nude mice bearing established human GEO colon cancer xenografts reveals a reversible dose-dependent inhibition of tumor growth because GEO tumors resumes the growth rate of controls at the end of the treatment. [4]

お薦めの試験操作(参考用のみ)

細胞試験: [1]
+ 展開
  • 細胞株: NR6, NR6M and NR6W cells
  • 濃度: 0-2 μM
  • 反応時間: 72 hours
  • 実験の流れ: Exponentially growing cells including NR6, NR6M, NR6M and NR6W cells are seeded in sextuple in 96-well plates at a concentration of 2000 cells/well, allowed to adhere and subsequently washed in PBS and incubated overnight in medium containing 0.5% FCS. Cells are then treated with varying concentrations (0-2 μM) of Gefitinib or the solute control DMSO and EGF. The optimal EGF concentration for inducing proliferation of NR6wtEGFR and NR6W cells has previously been determined and hence NR6wtEGFR and NR6W cells are supplemented with 10 nM and 0.1 nM EGF, respectively. EGF is not added to NR6 and NR6M cells. After 72 hours the amount of cells are measured by performing a MTT proliferation assay.
    (参考用のみ)
動物試験:[3]
+ 展開
  • 動物モデル: Female nude mice (cba nu/nu) aged 8–10 weeks are intra-dermal injected with LoVo cells.
  • 製剤: 0.5% polysorbate
  • 投薬量: 100 mg/kg
  • 投与方法: Once daily by oral administration (0.1 mL/10 g body weight) for 14 days
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 89 mg/mL (199.14 mM)
Ethanol 4 mg/mL (8.95 mM)
Water Insoluble
体内 左から右までの手順で、溶剤を製品に加えることです:
1% CMC Na
30mg/mL

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 446.90
化学式

C22H24ClFN4O3

CAS No. 184475-35-2
保管
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03050164 Completed Bioequivalence Study Hunan Kelun Pharmaceutical Co., Ltd. September 8, 2016 Phase 1
NCT02856893 Not yet recruiting NSCLC European Organisation for Research and Treatment of Cancer - EORTC|AstraZeneca March 2017 Phase 2
NCT02976116 Recruiting NSCLC Hutchison Medipharma Limited December 2016 Phase 2
NCT02951637 Not yet recruiting Lung Adenocarcinoma Shanghai Chest Hospital|Ruijin Hospital|Changhai Hospital December 2016 Phase 2
NCT02930954 Not yet recruiting Non-small-cell Lung Cancer Caicun Zhou|Tongji University November 2016 Phase 2
NCT02929693 Enrolling by invitation Cancer Shanghai University of Traditional Chinese Medicine|Shanghai Chest Hospital|Shanghai Pulmonary Hospital, Shanghai, China October 2016 Phase 3

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    I try to dissolve Gefitinib (ZD1839) in 0.5% methylcellulose+0.2% Tween 80 for in vivo experiments. However, when I prepare the mixture, it forms precipitates. Exists another way to dissolve completely the compound?

  • 回答:

    S1025 can be dissovled in both 5% DMSO+corn oil and 5% DMSO+30% PEG 300+5% Tween 80+ddH2O at 2.5 mg/ml clearly. It dissolves in DMSO not readily, please sonicate and warm it in water bath at about 45 degree, and dissolve it clearly first. Then add other solvent.

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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID