Gefitinib (ZD1839)

製品コードS1025

Gefitinib (ZD1839)化学構造

分子量(MW):446.90

Gefitinib (ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.

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JPY 31706.00
JPY 24402.00
JPY 44820.00

文献中の使用例(93)

カスタマーフィードバック(14)

  • c, HCC4006 lung cancer cells that have acquired a high-mesenchymal state concomitant with becoming resistant to gefitinib (red curve) exhibit increased sensitivity to GPX4 inhibition.

    Nature, 2017, 547(7664):453-457. Gefitinib (ZD1839) purchased from Selleck.

    Perturbation of EGFR by its ligand EGF and gefitinib (ZD-1839 Iressat; inhibits EGFR) produces opposite responses in the predicted EGFR target genes SOCS2 and NR2E1.

    Mol Syst Biol 2011 7, 486. Gefitinib (ZD1839) purchased from Selleck.

  • Effects of shRNA-mediated RECK depletion on EGFR signaling in MEFs. (a) Immunoblotting (IB) of the indicated proteins in wild-type MEFs transduced with the indicated shRNAs and cultured for 48 h in the presence of 0.1% dimethyl sulfoxide (DMSO; vehicle) or 1 mM gefitinib (S1025, Selleck Chemicals,Houston, TX, USA). (b) Immunoprecipitation from whole lysates of cells from panel a with an anti-phosphorylated tyrosine (pTyr) antibody. Precipitates from 500 mg protein in whole cell lysates (upper) or 20 mg protein in whole cell lysates (lower) were analyzed by IB with anti-EGFR antibody.

    Oncogene 2010 30, 737-750. Gefitinib (ZD1839) purchased from Selleck.

    (B–C) LNCaP (B) and LNCaP-AI (C) cells were transiently transfected with sPLA2-IIa(-800)-Luc (0.5 μg). The cells were then treated with Erlotinib (20 μM), Gefitinib (20 μM), Lapatinib (20 μM), CI-1033 (8 μM), LY294002 (20 lM) and Bortezomib (20 μM) without or with EGF (100 ng/ml) for 24 h. Luciferase assay was performed according to a standard protocol with Renilla luciferase as an internal control. Data are presented as the mean (±SD) of duplicate values of a representative experiment that was independently repeated for five times.

    Carcinogenesis 2010 31, 1948–1955 . Gefitinib (ZD1839) purchased from Selleck.

  • LNCaP-AI cells were starved in 1% stripped medium for 24 h. The cells were then treated with Erlotinib (20 μM), Gefitinib (20 μM), Lapatinib (20 μM), CI-1033 (8 μM), LY294002 (20 μM) and Bortezomib (20 μM) for 24 h. Cell culture medium was collected from each sample and subjected to ELISA for sPLA2-IIa. The condition medium samples were diluted 10 times for ELISA. Average of duplicate samples was converted to nanogram per milliliter against standard curve. The data represent one of five repeated experiments.

     

     

    Carcinogenesis 2010 31, 1948–1955. Gefitinib (ZD1839) purchased from Selleck.

    Susceptibility of lung cancer cells to cytolytic activity of NK-92 cells after treatment with EGFR inhibitors. Three lung cancer cells were untreated (open circle) or treated with 10 μM erlotinib or gefitinib (black filled square or black filled triangle) for 24 hours. The lung cancer cells were cocultured with NK-92 cells at indicated effector to target ratio (E:T ratio). To determine the specificity of NKG2D-mediated cytolysis of lung cancer cells, NK-92 cells were preincubated with blocking mAb against NKG2D before the assay (gray filled square and triangle) and correspond-ing isotype mAb (open square and triangle).

    J Immunother 2011 34(4), 372-81. Gefitinib (ZD1839) purchased from Selleck.

  • Suppression of EGFR signaling by Gefitinib is dose dependent and non- toxic at millimolar concentrations.Results from plaque reduction tests of Hep2 cells infected with VACV(12.5pfu/well) treated with a serial dilution of Gefitinib (1000-0.01 m) and analyzed for (A)proliferation as indicator of cytotoxicity,(B) IC50 of plaque size inhibition, (C)dose dependent inhibition of EGFR-ERK1/2signaling and VACV proteins by Western blot analysis (pEGFR detection was obtained from a different experiment with identicals ettings) and (D)dose dependent inhibition of orthopoxvirus genome replication by real-time PCR.Untreated VACV infectedcells and uninfected cells are shown as controls in the right panel.

    Antiviral Res 2010 89, 64-70. Gefitinib (ZD1839) purchased from Selleck.

    A circular zone of EGFR activated but uninfected cells facilitate virus induced plaque development , efficiently blocked by Gefitinib. (A)Immun of luorescent staining of aplaque reduction tests with Hep2 cells 24,48,72 and 96 h after VACV infection (6.25pfu/chamber). VACV infected cells(green) were visualized by human IgG directed to orthopoxviruses (VIG) detected with a secondary FITC labelled antibody. Uninfected cells with activated EGFR signaling(red) are detected with a secondary Cy3labelled antibody. Positive cells for both , VACV and phosphorylated EGFR are shown in yellow(merge). Cellular nuclei are counterstained with DAPI. (B)Immunofluorescent staining of a plaque reduction test as described for (A) and treated with three different Gefitinib concentrations (1000 nM, 1 nM, and 0.01 nM) . The test was analyzed 96h afterVACV infection.Uninfected cells are shown as controls. Magnification100×.(For interpretation of the references to color in this figure legend , the reader is referred to the web version of the article.)

     

     

    Antiviral Res 2010 89, 64-70. Gefitinib (ZD1839) purchased from Selleck.

  • The EGF-dependent increased association of PCM1 and AZI1 requires EGFR kinase activity. ZD1839 (Iressa)—EGFR tyrosine kinase inhibitor.

    Mol Biosyst 2011 7, 3223-33. Gefitinib (ZD1839) purchased from Selleck.

    Inhibition of 5-HT-induced 5-HT3A and 5-HT3AB receptor currents.

    Eur J Pharmacol, 2017, 821:21-28. Gefitinib (ZD1839) purchased from Selleck.

  • Reduction of GPER expression in HCC1806 cells after treatment with gefitinib. (A) Concentration dependence. HCC1806 cells were treated with 50-500 nM gefitinib for 48 h. GPER was detected by western blotting. (B) Time dependence. HCC1806 cells were treated with 200 nM gefitinib for 24-96 h. ap<0.05 vs. control; bp<0.001 vs. control. Mean values and SE of three independent experiments are shown. (C) Representative western blotting of concentration dependence. (D) Representative western blotting of time dependence

    Oncol Rep, 2017, 37(2):1212-1218. Gefitinib (ZD1839) purchased from Selleck.

    Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 215496. Gefitinib (ZD1839) purchased from Selleck.

  • Breast cancer cells were pretreated with 100ng/ml EGF for 15 min and then treated with the indicated concentrations of  Gefitinib for 24 hours.

     

     

    2010 Dr. Zhang of Tianjin Medical University. Gefitinib (ZD1839) purchased from Selleck.

    MTT assay result. 0-500nM Gefitinib treated with H1299, H358, H25 and HCC827 cell lines by 72h, Proliferation rate was tested.

     

     

    2010 Dr. Vicky Tin from University of Hong Kong. Gefitinib (ZD1839) purchased from Selleck.

製品安全説明書

EGFR阻害剤の選択性比較

生物活性

製品説明 Gefitinib (ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.
特性 A potent EGFR tyrosine kinase inhibitor.
ターゲット
Tyr1173 (NR6W cells) [1] Tyr1173 (NR6wtEGFR cells) [1] Tyr992 (NR6wtEGFR cells) [1] Tyr992 (NR6W cells) [1]
26 nM 37 nM 37 nM 57 nM
体外試験

Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low-EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition. Gefitinib effectively blocks the phosphorylation of PLC-γ, with IC50 of 27nM, in NR6W cells. The NR6wtEGFR and NR6M cell lines has low levels of PLC-γ phosphorylation but the level in the NR6M cell line is more resistant to inhibition by Gefitinib with IC50 of 43 nM and 369 nM, respectively. Gefitinib inhibits Akt phosphorylations, with IC50 of 220 and 263nM, in the low-EGFR- and -EGFRvIII-expressing cell lines, respectively. Gefitinib in the dose range from 0.1 to 0.5μM significantly facilitates, rather than abrogates, colony formation of NR6M cells. However, at a concentration of 2 μM Gefitinib completely blocks NR6M colony formation. Gefitinib rapidly and in a dose-dependent manner inhibits EGFR and ERK phosphorylation up to 72 hours after EGF stimulation in both the high- and low-EGFR-expressing cell lines. [1] Gefitinib is the monolayer growth of these EGF-driven untransformed MCF10A cells with an IC50 of 20 nM. [2] The combination of Gefitinib (0.2 μM and 0.5 μM) with irradiation lead to a significant growth inhibition in LoVo cells, compared with radiation alone.. [3]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KB M4PmVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm[wTWM2OD1yLkC1OEDPxE1? MV[xOlUyPjR5Mx?=
NIH3T3 Mn;ISpVv[3Srb36gRZN{[Xl? MkXFNE4zKM7:TR?= M4m1SFIhcA>? MUDEUXNQ NU[xcJM1UW6qaXLpeIlwdiCxZjDFS2Yhe3SrbYXsZZRm\CCqdX3hckBmemKEMTDheZRweGixc4Doc5J6dGG2aX;uJJdqfGhiSVO1NEBw\iByLkCxOFQh|ryP MXWxOlQ5ODJ6NB?=
COS7 MV\GeY5kfGmxbjDBd5NigQ>? M1ziSFk3KM7:TR?= M{LLZWlvcGmkaYTpc44hd2ZiaIXtZY4hUkGNMjDWOlE4TiCvdYThcpQh\XiycnXzd4Vl NInHXW8yPzF5OEeyNi=>
A549 NXHUNGhSS3m2b4TvfIlkKEG|c3H5 NIroeoY6PiCq MYDEUXNQ NY[2PZpKUUN3ME2xN{42QSEQvF2= MYWxPFMyOzhyNx?=
K562 M2LWUWN6fG:2b4jpZ{BCe3OjeR?= M2j4UVk3KGh? M2LiVGROW09? NWjDUZEzUUN3ME25MlM3KM7:TR?= MlzRNVg{OTN6MEe=
MDA-MB-231 M2flPWN6fG:2b4jpZ{BCe3OjeR?= M4K2TFk3KGh? MXXEUXNQ NV7HdpZGUUN3ME2zOk43OSEQvF2= MUKxPFMyOzhyNx?=
MOLT4 NYTLTWk6S3m2b4TvfIlkKEG|c3H5 MVq5OkBp MlTvSG1UVw>? NX\pZZd3UUN3ME2xOU4xOiEQvF2= MWCxPFMyOzhyNx?=
MCF7 MlfMR5l1d3SxeHnjJGF{e2G7 NVrrcYRzPTBizszN NFe4cHY4OiCq MXjJR|UxRTF{LkC1JO69VQ>? NYrsWZZXOTh5N{G4NVk>
BT474 NVW4TVVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDoVGZlPzJiaB?= MYLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKWNEe0JINmdGy|IH;2[ZJmgHC{ZYPzbY5oKEWUQnKyJJdqfGhiRVO1NEBw\iByLkOg{txO MVqxPVAzQDR{NB?=
HN5 NG\QSm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVu0cYh4PzJiaB?= MXTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiQNTDj[YxteyCxdnXy[ZhxemW|c3nu[{BGT0[UIIfpeIghTUN3MDDv[kAxNjBzIN88US=> MX2xPVAzQDR{NB?=
BA/F3 M{n3O2N6fG:2b4jpZ{BCe3OjeR?= MV23NkBp MW\DfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEWJRmKgUFg2QFJibYX0ZY51KHerdHigTWM2OCCxZjCwMlAyODhizszN MVGxPVI{QTJ{OR?=
NIH3T3 NVXZTVl3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\vblczKGh? M1;ibWdzd3e2aDDpcohq[mm2aX;uJI9nKG2xdYPlJG5KUC9|VEOgZ4VtdHNiZYjwdoV{e2mwZzDldmIzKGenbnWge4l1cCCLQ{WwJI9nKDBwNUSg{txO M3T2Z|E6PjZ3M{e3
MCF7 MX Mlm0SpVv[3Srb36gRZN{[Xl? MX2zNEBucW5? NUXWcJN6UW6qaXLpeIlwdiCxZjDCR3JRKGW6cILld5Nm\CC5aYToJGlEPTBib3[gNU4yKM7:TR?= MXixPVk{Ojl4MB?=
A431 NIDteINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEWzN|cyOCEQvF2= MV63NkBp MUHHTVUxRTBwNUG0JO69VQ>? NEfXboEyQTl4OUS2OS=>
A431 M37UOGtqdmG|ZTDBd5NigQ>? NXrDdZBlOC5zIN88US=> MWCxJIg> MkHaTY5pcWKrdHnvckBw\iCHR1[tbY5lfWOnZDDFS2ZTKHCqb4PwbI9zgWyjdHnvci=> M2TPbFE6QTZ7NE[1
A431 MY\LbY5ie2ViQYPzZZk> NIPLeoUyODBizszN NFL1TpMyOCCvaX6= NGXucHRRem:ub37n[YQhcW6qaXLpeI9zgSCjY4Tpeol1gSCxZjDFS2YucW6mdXPl[EBGT0[UIIDoc5NxcG:{eXzheIlwdg>? MlqyNVk6Pjl2NkW=
Sf9 M2G5[mtqdmG|ZTDBd5NigQ>? NIn2dmIyOCCvaX6= MkjDSG1UVw>? NUHQXlI{UW6qaXLpeIlwdiCxZjDFS2ZTKGW6cILld5Nm\CCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHKnY3XweI9zKGG3dH;wbI9{eGixconsZZRqd25id3n0bEBKSzVyIH;mJFAvODN|IN88US=> MUmyNFA2PjR{NR?=
NCI-H1975 NEnFUIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfEPWc2KM7:TR?= M1\hUFczKGh? MXnJR|UxRThwMk[g{txO NVPmeWNwOjBzNUG2O|A>
NCI-H1975 M33ufWtqdmG|ZTDBd5NigQ>? M1;KbVExKM7:TR?= Mmq5TY5pcWKrdHnvckBw\iCHR1\SJIF2fG:yaH;zdIhwenmuYYTpc44> M{Tob|IxOTVzNkew
NCI-H1975 MUjGeY5kfGmxbjDBd5NigQ>? M4XsNFExKM7:TR?= MkHITY5pcWKrdHnvckBw\iCHUlLCNkBifXSxcHjvd5Bpd3K7bHH0bY9v NGOzPHgzODF3MU[3NC=>
NCI-H1975 NXX4cpFSTnWwY4Tpc44hSXO|YYm= NXHkdmYyPSEQvF2= NF\v[IM1QCCq NUjrfldRUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDhd5Nme3OnZDDhd{Bi[3SrdnH0bY9vKG:oIHPhd5Bie2VvMx?= MoP5NlAyPTF4N{C=
A375 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\xR281QCCq MVTJR|UxRTJyLkW1JO69VQ>? MXWyNFMxPDV|Nx?=
SMMC7721 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3riPFQ5KGh? MorMTWM2OD1|Mz6xNkDPxE1? MUOyNFMxPDV|Nx?=
DU145 M{fXW2N6fG:2b4jpZ{BCe3OjeR?= MmOwOUBl NHvtbYNFVVOR MmrTTWM2OD12Mj6xO{DPxE1? NX7FZ|hSOjB2Nk[1OVU>
MIAPaCa2 NVHKUWhMS3m2b4TvfIlkKEG|c3H5 M{XG[VUh\A>? NITkVnBFVVOR NF34eI5KSzVyPUWwMlYzKM7:TR?= MX[yNFQ3PjV3NR?=
PANC1 MmS3R5l1d3SxeHnjJGF{e2G7 MnfSOUBl M3PHO2ROW09? MmjkTWM2OD12MD60NkDPxE1? MVGyNFQ3PjV3NR?=
PC9 NFW3WWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfFN5hkSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBGT0[ULXTl[olkcWWwdDDoeY1idiCSQ{mgZ4VtdHNid3n0bEBGSzVyIH;mJFAvODF5IN88US=> NHr5e20zOTJyOEiwNi=>
PC9 M2TYVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHfyc5d1cC2{ZYPpd5RidnRiaIXtZY4hWEN7IHPlcIx{KGW6cILld5NqdmdiRVfGVkBGPzR4X1G3OVAwXDd7MF2gcZV1[W62IIfpeIghTUN3MDDv[kA4KM7:TR?= M{XU[VIyOjB6OECy
PC3 M3zUSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nqbVExKM7:TR?= M1LWNVczKGh? MUDEUXNQ NFXKcZRKSzVyPUeuOEDPxE1? NWDpXYpxOjF|NUO1OFY>
MDA-MB-468 NWLOdYpCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HBZlExOCEQvF2= MVO0PEBp MoHzSG1UVw>? M1Hi[2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5 MVuyNVQzQTZ|Mh?=
Plasmodium falciparum MV\xTHRUKHC{b3\pcIlv\yCob4KgbY5pcWKrdH;yd{Bw\iCSbHHzcY9lcXWvIH\hcINqeGG{dX2gdJJwdGmoZYLheIlwdg>? NFvLW|MzOThzN{C0OS=>
NCI-H1993 MlToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jJVFczKGh? Mn2wSG1UVw>? NX3oSHZpUUN3ME2wMlEh|ryP NVTKd5B7OjF7MU[0N|M>
NCI-H292 MlvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDLRnA4OiCq M1HrVGROW09? MWDJR|UxRTBwMEKg{txO M4TReVIyQTF4NEOz
A431 MnPTT4lv[XOnIFHzd4F6 NUXuXII2OiCq MoGzSG1UVw>? MoG2TY5pcWKrdHnvckBw\iCHR1\SJJBpd3OyaH;yfYxifGmxbjDpckBGT0Zvc4TpcZVt[XSnZDDoeY1idiCDNEOxJJdqfGhiSVO1NEBw\iByLkCwNUDPxE1? Ml24NlIyODFzM{K=
MCF7 NEPRRWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfGcI9DOTBywrFOwIcwdUx? MljqOFghcA>? NHjqe3JFVVOR Mmr3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IH;2[ZJmgHC{ZYPzbY5oKEWJRmKg[4Vv\SC5aYToJGlEPTBib3[gNVIvODVizszN M13ETFIzOTF7MUOw
BT474 MYDDfZRwfG:6aXOgRZN{[Xl? NEfIXVEyOCEQvF2= M1vKe|Q5KGh? MV3DfZRwfG:6aXPpeJkh[WejaX7zeEB{\XK3bT3zeIFzfmWmIHj1cYFvKEKWNEe0JINmdGy| M1TWSVIzOTN6M{C4
MCF7 NVr2W2g4S3m2b4TvfIlkKEG|c3H5 Mke3NVAh|ryP MYW0PEBp MV3DfZRwfG:6aXPpeJkh[WejaX7zeEB{\XK3bT3zeIFzfmWmIHj1cYFvKE2FRkegZ4VtdHNib4\ldk1mgHC{ZYPzbY5oKEW{YlKyJINmdGy| NIji[YgzOjF|OEOwPC=>
HCC827 MV3LbY5ie2ViQYPzZZk> NYWwTlFrOC5zMkWg{txO NH;wcFgzPCCq NWGzRm9iTE2VTx?= MWTJcohq[mm2aX;uJI9nKEWJRmKg[IVtKEV5NE[tRVc2OCCvdYThcpQhYTFyNkigZZV1d3Cqb4PwbI9zgWyjdHnvci=> NFv5UYUzOjN|OUO0Ni=>
HCC827 MoPVT4lv[XOnIFHzd4F6 NEDnN4ExNjF{NTFOwG0> MYqyOEBp NHXOUnZFVVOR MVnJcohq[mm2aX;uJI9nKEWJRmKg[IVtKEV5NE[tRVc2OCCvdYThcpQudWWmaXH0[YQhTXKtIIDoc5NxcG:{eXzheIlwdg>? MnzFNlI{Ozl|NEK=
HCC827 NF\rNGhMcW6jc3WgRZN{[Xl? MXqwMlEzPSEQvF2= NUXGVpp7OjRiaB?= MlrDSG1UVw>? NGfhSoxKdmirYnn0bY9vKG:oIFXHSnIh\GWuIFW3OFYuSTd3MDDteZRidnRvbXXkbYF1\WRiQXv0JJBpd3OyaH;yfYxifGmxbh?= NH7rTpgzOjN|OUO0Ni=>
A431 NIrX[VRMcW6jc3WgRZN{[Xl? NUPCNXhwOTByIN88US=> NYG2eoVyOzBibXnu MkHPTY5pcWKrdHnvckBw\iCHR1\SJIRmemm4ZXSg[pJwdSCqdX3hckBCPDNzIHPlcIwhdWWvYoLhcoUh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBxd2y7LVfseU1VgXJicHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCxMlA5KM7:TR?= NHLieVYzOjZ7OEe4Ni=>
H460 MWXDfZRwfG:6aXOgRZN{[Xl? NHTwNWg4OiCq Ml3zTWM2OD13LkW5JO69VQ>? Mm\xNlI4Ojd2NEm=
HT-29 MVjDfZRwfG:6aXOgRZN{[Xl? MmXWO|IhcA>? NHH1bWNKSzVyPUOuN|Yh|ryP MmnaNlI4Ojd2NEm=
SGC7901 NITFc5ZEgXSxdH;4bYMhSXO|YYm= NWHmZ3U5PzJiaB?= M2OyZ2lEPTB;MUCuNlYh|ryP MV:yNlczPzR2OR?=
A498 M3P2VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF2OUigZ4VtdHNiZYjwdoV{e2mwZzDFS2ZTKGGwZDDTVmMhf2m2aDDJR|UxKG:oIEiuOkDPxE1? MnLvNlI5OTh6NEi=
Calu3 NUP2eHVTS3m2b4TvfIlkKEG|c3H5 MmT5NVAh|rypL33M NGP6bno4OiCq MXXJR|UxRTFwNjFOwG0> NVrZRo5KOjNzMU[xOlg>
FADU M4HibGN6fG:2b4jpZ{BCe3OjeR?= M3;mPVExKM7:Zz;tUC=> NVrxU5JjPzJiaB?= Mlv3TWM2OD1yLkC1JO69VQ>? MYmyN|EyPjF4OB?=
HCC827 M3TPPWN6fG:2b4jpZ{BCe3OjeR?= M3W4Z|ExKM7:Zz;tUC=> NFXJdFk4OiCq NVO0dmt[UUN3ME2wMlAxOTVizszN MYKyN|EyPjF4OB?=
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Sf9 NYDJeWd1U2mwYYPlJGF{e2G7 M1m4U|EhcA>? MmDlSG1UVw>? M3S0XGlvcGmkaYTpc44hd2ZiaIXtZY4hT1OWLYTh[4dm\CCHR1\SJGw5OzSUIH31eIFvfCCneIDy[ZN{\WRid3n0bEBKSzVyIH;mJFAvODF3IN88US=> M3\yNFI{PjFzNkmx
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IGROV-1 NWHPbnJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfJd|VNUUN3ME2yMlMyOjN5IN88US=> NFrk[HRUSU6JRWK=
JVM-3 NIPJWVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvTN|dKSzVyPUKuN|Q3PDNizszN NHTNS45USU6JRWK=
NCI-H2170 NUnMWIVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTJwM{S3PFMh|ryP MVjTRW5ITVJ?
EW-18 MkT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTJwM{W0O|Eh|ryP NWrQZVJZW0GQR1XS
KU812 NUXobJc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MluyTWM2OD1{LkO2O|c6KM7:TR?= MnHCV2FPT0WU
NY NYnTdZNtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHTT2NKSzVyPUKuN|czPyEQvF2= NULxfJp6W0GQR1XS
HTC-C3 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDmUJl2UUN3ME2yMlQzOjZ5IN88US=> MWrTRW5ITVJ?
CFPAC-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;EOmlEPTB;Mj60N|g3PCEQvF2= Mk\rV2FPT0WU
HH NV7CXldCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jVZ2lEPTB;Mj60PVg2PCEQvF2= MoK5V2FPT0WU
MKN7 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTJwNkK3OFgh|ryP MYjTRW5ITVJ?
TE-8 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLaZlI2UUN3ME2yMlY{PjV|IN88US=> NFzq[3NUSU6JRWK=
MC-IXC NIfPXFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVz1NHEyUUN3ME2yMlY1PDV|IN88US=> NHuwbmFUSU6JRWK=
DMS-79 MknpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTJwNkmyPFQh|ryP MlH3V2FPT0WU
Detroit562 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDSTWM2OD1{Lk[5PFQ2KM7:TR?= NX6weFJCW0GQR1XS
HuP-T4 MkjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\r[2lEPTB;Mj63NlgyQCEQvF2= NVrrZpNPW0GQR1XS
QIMR-WIL M2nQNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTJwN{W5OVIh|ryP M4HxT3NCVkeHUh?=
BB65-RCC MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELMTHNKSzVyPUKuPFA4OTNizszN MWnTRW5ITVJ?
PC-3 MnjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTJwOEOzNVch|ryP NYiyPYVDW0GQR1XS
OVCAR-3 NFLrbYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;Re2lEPTB;Mj64OVU6PCEQvF2= MlPFV2FPT0WU
KYSE-510 NXO4c|R3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jBVWlEPTB;Mj64Olc5PiEQvF2= M3uw[nNCVkeHUh?=
HC-1 MoDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTJwOUSwNVIh|ryP MljPV2FPT0WU
NCI-H1693 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUD4UmRFUUN3ME2yMlk2QDl5IN88US=> M{TvU3NCVkeHUh?=
DU-4475 MkezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF[4NXhKSzVyPUKuPVkxPTJizszN MVPTRW5ITVJ?
COLO-680N MoDHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;3S2xKSzVyPUOuNFA1QTVizszN M2jWOnNCVkeHUh?=
MN-60 NXW5W4dQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXGdpprUUN3ME2zMlA1QTd2IN88US=> NVnKRYlwW0GQR1XS
BCPAP MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfRTWM2OD1|LkC4Nlk2KM7:TR?= NYPHcXBvW0GQR1XS
647-V MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fpfWlEPTB;Mz6xOlIzKM7:TR?= NWPseopXW0GQR1XS
HT-1376 NUDTR5pNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF60dWxKSzVyPUOuNlA2ODZizszN NXv0VpBZW0GQR1XS
NCI-H1793 NVTJendzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PJc2lEPTB;Mz6yNVA6QCEQvF2= NUTxXI9oW0GQR1XS
SW1463 M4jvTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTNwMk[xPVIh|ryP NFH2XYdUSU6JRWK=
NCI-H727 NXnBU3k6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\YTWM2OD1|LkO4OVg1KM7:TR?= MYjTRW5ITVJ?
LB771-HNC NYK5c3AxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHJT|N3UUN3ME2zMlM6OTJ4IN88US=> NWn5dYJrW0GQR1XS
D-542MG NH;N[pBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTNwNESyNlIh|ryP NHz6PGNUSU6JRWK=
NTERA-S-cl-D1 M1zuZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTNwNES5OVch|ryP MmqyV2FPT0WU
C8166 MmnyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXvcoJpUUN3ME2zMlQ3PTJzIN88US=> NX7VXWN7W0GQR1XS
639-V M4L3VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTNwNUe3PVIh|ryP MnHyV2FPT0WU
TE-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nWT2lEPTB;Mz61PVE3QSEQvF2= M2PQV3NCVkeHUh?=
OAW-28 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M171VWlEPTB;Mz61PVQzPiEQvF2= MljoV2FPT0WU
SK-LU-1 NVnzNWhqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1[5T2lEPTB;Mz62NFY1PSEQvF2= M1X5[HNCVkeHUh?=
CaR-1 NFHVZ5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrBTWM2OD1|Lk[xNFQ5KM7:TR?= MmX2V2FPT0WU
A2780 Mn21S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTnTWM2OD1|Lk[0NFg6KM7:TR?= M3WyUnNCVkeHUh?=
C2BBe1 M1zSc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzFTWM2OD1|Lk[0OFA4KM7:TR?= MVnTRW5ITVJ?
SK-MES-1 NVfFUG5yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTNwNkS2NVQh|ryP MVzTRW5ITVJ?
PANC-10-05 M4rOeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTNwN{KwO|Ih|ryP NXX2VVJwW0GQR1XS
J-RT3-T3-5 MoXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzuTWM2OD1|Lke1OFA3KM7:TR?= MlHtV2FPT0WU
ES4 NIfDZoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrJOHNsUUN3ME2zMlgzOjh4IN88US=> NX62PWhKW0GQR1XS
NCI-H28 NH[5ZWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjab5hKSzVyPUOuPFI6PjFizszN NV7CRmNQW0GQR1XS
NCI-H1155 NYLubot7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPDR5hKSzVyPUOuPFQyPTlizszN M1fmOXNCVkeHUh?=
KURAMOCHI Mmj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTNwOE[wOVYh|ryP NEG1V4NUSU6JRWK=
NCI-H69 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PJR2lEPTB;Mz65NFE4QCEQvF2= M{\IWHNCVkeHUh?=
IST-MES1 NXnjO|FJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHCTWM2OD1|Lkm0NFI6KM7:TR?= M1XmbHNCVkeHUh?=
NH-12 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF76TYVKSzVyPUOuPVQyQDdizszN MY\TRW5ITVJ?
JVM-2 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYO2bIxTUUN3ME2zMlk1PzV{IN88US=> NULKeGhRW0GQR1XS
EW-16 M2fZVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vubWlEPTB;Mz65OVU4PyEQvF2= NFLBXXlUSU6JRWK=
NCI-H441 M2fUS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTNwOUewNVQh|ryP Ml3vV2FPT0WU
RCC10RGB NFXI[YpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn:5TWM2OD12LkCxNlQ3KM7:TR?= NHHXPHpUSU6JRWK=
TCCSUP NIXJWWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjCTWM2OD12LkGxNFUh|ryP MX7TRW5ITVJ?
HL-60 NUjGdoZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX35V25yUUN3ME20MlEzOjRzIN88US=> M1yw[nNCVkeHUh?=
EW-11 NHq4c|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHhWnpKSzVyPUSuNVMzPjFizszN Mof4V2FPT0WU
KARPAS-299 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfDWG1KSzVyPUSuN|ExOTNizszN MYXTRW5ITVJ?
SNU-C2B NFXXbGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXRToV7UUN3ME20MlM1Pjh4IN88US=> NFv0Ro5USU6JRWK=
LU-139 NFTnVlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33SZ2lEPTB;ND6zO|I1PyEQvF2= M2DHcHNCVkeHUh?=
HCC1937 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTRwM{e5PVMh|ryP MX3TRW5ITVJ?
GR-ST M2jzbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVf1Xm5rUUN3ME20MlQ{OThizszN MVTTRW5ITVJ?
SK-OV-3 NVv3TYh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\tVJMzUUN3ME20MlQ3ODR{IN88US=> MlTCV2FPT0WU
A172 NHjISpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrXTXJRUUN3ME20MlU2PTJzIN88US=> M{e5VnNCVkeHUh?=
NB10 NWrSNHVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTRwNUm3PFEh|ryP MlL4V2FPT0WU
P30-OHK NHzsd4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3uTWM2OD12LkixPVI6KM7:TR?= MoHLV2FPT0WU
KYSE-520 M3vaPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{n2bmlEPTB;ND64PFAyQCEQvF2= MkHNV2FPT0WU
KNS-62 NXvQSYEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTRwOUC4NFch|ryP M4fyZXNCVkeHUh?=
ES1 NGPsXotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3MeHU6UUN3ME20Mlk3ODN3IN88US=> NI\NSIVUSU6JRWK=
KOSC-2 NUDXcFhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjV[3pKUUN3ME20Mlk6QTV7IN88US=> M1r1[3NCVkeHUh?=
TE-9 Ml;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH71SpZKSzVyPUWuNFE2OjVizszN NVW3fWoxW0GQR1XS
NCI-H1838 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTVwMEKwO|Yh|ryP MmXRV2FPT0WU
KP-N-YN NWLxZ3ZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fQZmlEPTB;NT6xNlU6OSEQvF2= NEXiTGpUSU6JRWK=
ALL-PO MoG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGP3U49KSzVyPUWuNlI2QDdizszN Mnf3V2FPT0WU
NOMO-1 NX7MR|Y3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTVwMkOxO|Yh|ryP M4nV[XNCVkeHUh?=
CGTH-W-1 NIr1OmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnf5TWM2OD13LkO4OVg1KM7:TR?= M1vCT3NCVkeHUh?=
ATN-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1yyVGlEPTB;NT60NVE5PCEQvF2= M1;mbHNCVkeHUh?=
AGS M3rZVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrwTWM2OD13LkS5OlE5KM7:TR?= MkTYV2FPT0WU
SW13 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4T2PGlEPTB;NT61N|I3PSEQvF2= Mn\GV2FPT0WU
SW1990 NHXlSWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4e5PWlEPTB;NT62NlI5PSEQvF2= NWDkWIRQW0GQR1XS
BFTC-905 NIHr[XJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEOwVZNKSzVyPUWuOlU5PzhizszN MVXTRW5ITVJ?
RMG-I M1eybGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfPTWM2OD13Lk[1PVQzKM7:TR?= MVfTRW5ITVJ?
HD-MY-Z NFjZOJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoH1TWM2OD13Lk[4OVgyKM7:TR?= NYrBW3VOW0GQR1XS
HCC1187 NYS5VFNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LKeGlEPTB;NT63NVA{OiEQvF2= NUjhfoJJW0GQR1XS
HCC2998 MlrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jhdGlEPTB;NT63NVg4PyEQvF2= MkiwV2FPT0WU
RT-112 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjEPXNJUUN3ME21MlkxOjR3IN88US=> M4Dl[nNCVkeHUh?=
CAKI-1 MmrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrUTnF1UUN3ME22MlAxQTh3IN88US=> NFOzV4RUSU6JRWK=
HDLM-2 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWW0eVFmUUN3ME22MlAyPDh7IN88US=> NXX3VYZEW0GQR1XS
TE-10 M2[2PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLJSm1EUUN3ME22MlA1QDN|IN88US=> NH:2OWdUSU6JRWK=
KE-37 NXfxfXFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnTT5FiUUN3ME22MlA4OjV6IN88US=> MX\TRW5ITVJ?
RCM-1 NWW2epdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlv3TWM2OD14LkC3O|E6KM7:TR?= M{fEfXNCVkeHUh?=
Mewo M3vPSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTZwMUG0PFch|ryP NH\2VnZUSU6JRWK=
L-428 NInvZ|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULUSoh2UUN3ME22MlE5ODN5IN88US=> MkXLV2FPT0WU
8-MG-BA MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rMXWlEPTB;Nj6xPVM4QSEQvF2= NV3je4VQW0GQR1XS
SK-MEL-28 Ml7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrjXY1KSzVyPU[uNlA6PjdizszN MWHTRW5ITVJ?
VA-ES-BJ NFy0OG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTZwM{C0OlIh|ryP NWX5bIZsW0GQR1XS
CAL-120 MmrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjOVlJKSzVyPU[uOFUyPjJizszN NVX6eGM2W0GQR1XS
GAMG NGnOWlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlP4TWM2OD14LkWwOlIh|ryP NGS0[2pUSU6JRWK=
MSTO-221H MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TJOGlEPTB;Nj61NVE4KM7:TR?= NGr0ZnRUSU6JRWK=
GCT M17RV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTZwNUOzPFch|ryP NUj2R|JzW0GQR1XS
SH-4 NUn0[I1nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;3eJVKSzVyPU[uOVg5PDRizszN MmflV2FPT0WU
Calu-3 M2XVSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fpVmlEPTB;Nj62OVU3QCEQvF2= MoDmV2FPT0WU
SK-HEP-1 NIfm[lNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTZwN{G3OVMh|ryP NUfMfXg6W0GQR1XS
PFSK-1 M1r6cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TZSmlEPTB;Nj63N|Q4QCEQvF2= NETMZmFUSU6JRWK=
NB12 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2n3VGlEPTB;Nj63PFQxPCEQvF2= Ml31V2FPT0WU
A388 NHH4e3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHKc|JVUUN3ME22Mlg6PTJizszN M{TFO3NCVkeHUh?=
KLE MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fDPGlEPTB;Nj65OlUyPiEQvF2= MnvUV2FPT0WU
TE-11 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LrWmlEPTB;Nz6wOFk3PyEQvF2= M3[4RnNCVkeHUh?=
NCI-H2405 MmjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTdwMEizPVMh|ryP M2HkNnNCVkeHUh?=
OVCAR-4 MlnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTrTWM2OD15LkG1N|Uh|ryP NWHoeYRGW0GQR1XS
KP-N-YS NYjiO3Y3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrNVZFKSzVyPUeuNVgyPCEQvF2= MYfTRW5ITVJ?
NOS-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHs[WlKSzVyPUeuNlU5OjhizszN M3S5WHNCVkeHUh?=
DMS-114 NHfkVpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljXTWM2OD15LkK5OlMyKM7:TR?= M2DmenNCVkeHUh?=
NCI-H2030 M1\K[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfZTWM2OD15LkOzOlk5KM7:TR?= NHv0RlBUSU6JRWK=
HEL NWPVNIRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XwcGlEPTB;Nz6zO|UzOSEQvF2= M37YbXNCVkeHUh?=
CAL-62 Mnn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;xTWM2OD15LkO5PFY3KM7:TR?= M2HpV3NCVkeHUh?=
COLO-668 M4ToZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXBTY1KSzVyPUeuOFM6PjdizszN M4C1U3NCVkeHUh?=
SKG-IIIa NV\mRW95T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fqPGlEPTB;Nz60OVM5OSEQvF2= MojZV2FPT0WU
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T98G MoTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\PbWlEPTB;M{euPFY{PSEQvF2= NX7yT5VzW0GQR1XS
NB14 NVjiU2U2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrBTWM2OD1|OD60OVQ1KM7:TR?= NFjVfYNUSU6JRWK=
D-423MG MnnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\GS2FlUUN3ME2zPE41QDZ7IN88US=> NH\iTotUSU6JRWK=
NCI-H510A MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIiw[ZhKSzVyPUO4MlY1PTFizszN MYHTRW5ITVJ?
NMC-G1 NFrlSGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXX6OWx[UUN3ME2zPE44OjJ{IN88US=> MojFV2FPT0WU
SW948 NX\EPHA5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTN6Lki5OFkh|ryP MUnTRW5ITVJ?
MFM-223 NYXrSItTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX2zeogxUUN3ME2zPE46PDNzIN88US=> NXmyeW45W0GQR1XS
PAN1 NFHlfplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\icWlEPTB;M{iuPVkyQSEQvF2= M2PV[HNCVkeHUh?=
MZ7-mel M2TYXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTN7LkGxPVkh|ryP Ml;PV2FPT0WU
COLO-679 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3j[o1mUUN3ME2zPU46PzB6IN88US=> MX3TRW5ITVJ?
SW872 NVj0T3lPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1Xoc2lEPTB;NECuNlA{OSEQvF2= MnT5V2FPT0WU
HT-1197 NXnSOmJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;aTmlEPTB;NECuNlg3QSEQvF2= MY\TRW5ITVJ?
ES6 M136OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{S5N2lEPTB;NECuOFU2OiEQvF2= Mkj2V2FPT0WU
SNU-387 MmPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2X1VGlEPTB;NECuPFI{QCEQvF2= M37iOHNCVkeHUh?=
T47D NWrYZm9ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\STWM2OD12MT6wNVkzKM7:TR?= NF2wU5FUSU6JRWK=
G-402 M1TQeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoeyTWM2OD12MT6wPFA6KM7:TR?= Mo[1V2FPT0WU
MZ1-PC NXvMeJBlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjDTWM2OD12MT64NUDPxE1? M{j2W3NCVkeHUh?=
SW1417 NXTweHpGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkf5TWM2OD12Mj6zNFMh|ryP MkDpV2FPT0WU
RERF-LC-MS NWPZTFVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHYdFVKSzVyPUSyMlUxQDdizszN M1GzfnNCVkeHUh?=
SF539 NHWxXmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjrNmJ3UUN3ME20Nk42PTJ7IN88US=> NIG4XWdUSU6JRWK=
ESS-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DCRmlEPTB;NEOuOVU2QCEQvF2= MmD4V2FPT0WU
RO82-W-1 NYTGcJBMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jmemlEPTB;NEOuOlE2OyEQvF2= NGPa[VBUSU6JRWK=
S-117 M{jCTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLpTWM2OD12Mz62PVU5KM7:TR?= NGXuN2FUSU6JRWK=
SW756 MkLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTR|LkiyOFIh|ryP NUL4[XJLW0GQR1XS
CP66-MEL M1zRWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjOTWM2OD12NT63NVQ{KM7:TR?= Mn3BV2FPT0WU
H-EMC-SS M4\tbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGf1c41KSzVyPUS1Mlc3QTNizszN M4\zXnNCVkeHUh?=
NCI-H2052 NFHHdHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrsc2h2UUN3ME20OU46ODJ5IN88US=> NVzS[FIxW0GQR1XS
SW684 M{O4SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjMTWM2OD12Nz6wNFgyKM7:TR?= NHzhXGVUSU6JRWK=
HCC1569 M2Xkcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX:1[WZtUUN3ME20O{4yPjV6IN88US=> MlvXV2FPT0WU
KGN MnTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PXT2lEPTB;NEeuN|MyOSEQvF2= NVPVS3p3W0GQR1XS
LCLC-103H MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHT2UY1KSzVyPUS3MlQ1ODRizszN NUDrSXBNW0GQR1XS
SW780 M1XRdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTR5Lk[zOVEh|ryP NVLpRW5tW0GQR1XS
NCI-H1703 MkD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vMUGlEPTB;NEiuN|M2OiEQvF2= M4D0eXNCVkeHUh?=
HCC1395 NYHiOGIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmWyTWM2OD12OD63OFMzKM7:TR?= Mny1V2FPT0WU

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

体内試験 Gefitinib (100 mg/kg) improves the anti-tumor effect of radiotherapy in LoVo tumor xenografts. [3] Gefitinib treatment of nude mice bearing established human GEO colon cancer xenografts reveals a reversible dose-dependent inhibition of tumor growth because GEO tumors resumes the growth rate of controls at the end of the treatment. [4]

お薦めの試験操作(参考用のみ)

細胞試験: [1]
+ 展開
  • 細胞株: NR6, NR6M and NR6W cells
  • 濃度: 0-2 μM
  • 反応時間: 72 hours
  • 実験の流れ: Exponentially growing cells including NR6, NR6M, NR6M and NR6W cells are seeded in sextuple in 96-well plates at a concentration of 2000 cells/well, allowed to adhere and subsequently washed in PBS and incubated overnight in medium containing 0.5% FCS. Cells are then treated with varying concentrations (0-2 μM) of Gefitinib or the solute control DMSO and EGF. The optimal EGF concentration for inducing proliferation of NR6wtEGFR and NR6W cells has previously been determined and hence NR6wtEGFR and NR6W cells are supplemented with 10 nM and 0.1 nM EGF, respectively. EGF is not added to NR6 and NR6M cells. After 72 hours the amount of cells are measured by performing a MTT proliferation assay.
    (参考用のみ)
動物試験:[3]
+ 展開
  • 動物モデル: Female nude mice (cba nu/nu) aged 8–10 weeks are intra-dermal injected with LoVo cells.
  • 製剤: 0.5% polysorbate
  • 投薬量: 100 mg/kg
  • 投与方法: Once daily by oral administration (0.1 mL/10 g body weight) for 14 days
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 89 mg/mL (199.14 mM)
Ethanol 4 mg/mL (8.95 mM)
Water Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
1% CMC Na
混合させたのち直ちに使用することを推奨します。
30mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 446.90
化学式

C22H24ClFN4O3

CAS No. 184475-35-2
保管
in solvent
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03050164 Completed Bioequivalence Study Hunan Kelun Pharmaceutical Co., Ltd. September 8, 2016 Phase 1
NCT02856893 Not yet recruiting NSCLC European Organisation for Research and Treatment of Cancer - EORTC|AstraZeneca March 2017 Phase 2
NCT02976116 Recruiting NSCLC Hutchison Medipharma Limited December 2016 Phase 2
NCT02951637 Not yet recruiting Lung Adenocarcinoma Shanghai Chest Hospital|Ruijin Hospital|Changhai Hospital December 2016 Phase 2
NCT02930954 Not yet recruiting Non-small-cell Lung Cancer Caicun Zhou|Tongji University November 2016 Phase 2
NCT02929693 Enrolling by invitation Cancer Shanghai University of Traditional Chinese Medicine|Shanghai Chest Hospital|Shanghai Pulmonary Hospital, Shanghai, China October 2016 Phase 3

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    I try to dissolve Gefitinib (ZD1839) in 0.5% methylcellulose+0.2% Tween 80 for in vivo experiments. However, when I prepare the mixture, it forms precipitates. Exists another way to dissolve completely the compound?

  • 回答:

    S1025 can be dissovled in both 5% DMSO+corn oil and 5% DMSO+30% PEG 300+5% Tween 80+ddH2O at 2.5 mg/ml clearly. It dissolves in DMSO not readily, please sonicate and warm it in water bath at about 45 degree, and dissolve it clearly first. Then add other solvent.

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