Gefitinib (ZD1839)

製品コードS1025

Gefitinib (ZD1839)化学構造

分子量(MW):446.90

Gefitinib (ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.

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JPY 44820.00

文献中の使用例(92)

カスタマーフィードバック(13)

  • Perturbation of EGFR by its ligand EGF and gefitinib (ZD-1839 Iressat; inhibits EGFR) produces opposite responses in the predicted EGFR target genes SOCS2 and NR2E1.

    Mol Syst Biol 2011 7, 486. Gefitinib (ZD1839) purchased from Selleck.

    Effects of shRNA-mediated RECK depletion on EGFR signaling in MEFs. (a) Immunoblotting (IB) of the indicated proteins in wild-type MEFs transduced with the indicated shRNAs and cultured for 48 h in the presence of 0.1% dimethyl sulfoxide (DMSO; vehicle) or 1 mM gefitinib (S1025, Selleck Chemicals,Houston, TX, USA). (b) Immunoprecipitation from whole lysates of cells from panel a with an anti-phosphorylated tyrosine (pTyr) antibody. Precipitates from 500 mg protein in whole cell lysates (upper) or 20 mg protein in whole cell lysates (lower) were analyzed by IB with anti-EGFR antibody.

    Oncogene 2010 30, 737-750. Gefitinib (ZD1839) purchased from Selleck.

  • (B–C) LNCaP (B) and LNCaP-AI (C) cells were transiently transfected with sPLA2-IIa(-800)-Luc (0.5 μg). The cells were then treated with Erlotinib (20 μM), Gefitinib (20 μM), Lapatinib (20 μM), CI-1033 (8 μM), LY294002 (20 lM) and Bortezomib (20 μM) without or with EGF (100 ng/ml) for 24 h. Luciferase assay was performed according to a standard protocol with Renilla luciferase as an internal control. Data are presented as the mean (±SD) of duplicate values of a representative experiment that was independently repeated for five times.

    Carcinogenesis 2010 31, 1948–1955 . Gefitinib (ZD1839) purchased from Selleck.

    LNCaP-AI cells were starved in 1% stripped medium for 24 h. The cells were then treated with Erlotinib (20 μM), Gefitinib (20 μM), Lapatinib (20 μM), CI-1033 (8 μM), LY294002 (20 μM) and Bortezomib (20 μM) for 24 h. Cell culture medium was collected from each sample and subjected to ELISA for sPLA2-IIa. The condition medium samples were diluted 10 times for ELISA. Average of duplicate samples was converted to nanogram per milliliter against standard curve. The data represent one of five repeated experiments.

     

     

    Carcinogenesis 2010 31, 1948–1955. Gefitinib (ZD1839) purchased from Selleck.

  • Susceptibility of lung cancer cells to cytolytic activity of NK-92 cells after treatment with EGFR inhibitors. Three lung cancer cells were untreated (open circle) or treated with 10 μM erlotinib or gefitinib (black filled square or black filled triangle) for 24 hours. The lung cancer cells were cocultured with NK-92 cells at indicated effector to target ratio (E:T ratio). To determine the specificity of NKG2D-mediated cytolysis of lung cancer cells, NK-92 cells were preincubated with blocking mAb against NKG2D before the assay (gray filled square and triangle) and correspond-ing isotype mAb (open square and triangle).

    J Immunother 2011 34(4), 372-81. Gefitinib (ZD1839) purchased from Selleck.

    Suppression of EGFR signaling by Gefitinib is dose dependent and non- toxic at millimolar concentrations.Results from plaque reduction tests of Hep2 cells infected with VACV(12.5pfu/well) treated with a serial dilution of Gefitinib (1000-0.01 m) and analyzed for (A)proliferation as indicator of cytotoxicity,(B) IC50 of plaque size inhibition, (C)dose dependent inhibition of EGFR-ERK1/2signaling and VACV proteins by Western blot analysis (pEGFR detection was obtained from a different experiment with identicals ettings) and (D)dose dependent inhibition of orthopoxvirus genome replication by real-time PCR.Untreated VACV infectedcells and uninfected cells are shown as controls in the right panel.

    Antiviral Res 2010 89, 64-70. Gefitinib (ZD1839) purchased from Selleck.

  • A circular zone of EGFR activated but uninfected cells facilitate virus induced plaque development , efficiently blocked by Gefitinib. (A)Immun of luorescent staining of aplaque reduction tests with Hep2 cells 24,48,72 and 96 h after VACV infection (6.25pfu/chamber). VACV infected cells(green) were visualized by human IgG directed to orthopoxviruses (VIG) detected with a secondary FITC labelled antibody. Uninfected cells with activated EGFR signaling(red) are detected with a secondary Cy3labelled antibody. Positive cells for both , VACV and phosphorylated EGFR are shown in yellow(merge). Cellular nuclei are counterstained with DAPI. (B)Immunofluorescent staining of a plaque reduction test as described for (A) and treated with three different Gefitinib concentrations (1000 nM, 1 nM, and 0.01 nM) . The test was analyzed 96h afterVACV infection.Uninfected cells are shown as controls. Magnification100×.(For interpretation of the references to color in this figure legend , the reader is referred to the web version of the article.)

     

     

    Antiviral Res 2010 89, 64-70. Gefitinib (ZD1839) purchased from Selleck.

    The EGF-dependent increased association of PCM1 and AZI1 requires EGFR kinase activity. ZD1839 (Iressa)—EGFR tyrosine kinase inhibitor.

    Mol Biosyst 2011 7, 3223-33. Gefitinib (ZD1839) purchased from Selleck.

  • Inhibition of 5-HT-induced 5-HT3A and 5-HT3AB receptor currents.

    Eur J Pharmacol, 2017, 821:21-28. Gefitinib (ZD1839) purchased from Selleck.

    Reduction of GPER expression in HCC1806 cells after treatment with gefitinib. (A) Concentration dependence. HCC1806 cells were treated with 50-500 nM gefitinib for 48 h. GPER was detected by western blotting. (B) Time dependence. HCC1806 cells were treated with 200 nM gefitinib for 24-96 h. ap<0.05 vs. control; bp<0.001 vs. control. Mean values and SE of three independent experiments are shown. (C) Representative western blotting of concentration dependence. (D) Representative western blotting of time dependence

    Oncol Rep, 2017, 37(2):1212-1218. Gefitinib (ZD1839) purchased from Selleck.

  • Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 215496. Gefitinib (ZD1839) purchased from Selleck.

    Breast cancer cells were pretreated with 100ng/ml EGF for 15 min and then treated with the indicated concentrations of  Gefitinib for 24 hours.

     

     

    2010 Dr. Zhang of Tianjin Medical University. Gefitinib (ZD1839) purchased from Selleck.

  • MTT assay result. 0-500nM Gefitinib treated with H1299, H358, H25 and HCC827 cell lines by 72h, Proliferation rate was tested.

     

     

    2010 Dr. Vicky Tin from University of Hong Kong. Gefitinib (ZD1839) purchased from Selleck.

製品安全説明書

EGFR阻害剤の選択性比較

生物活性

製品説明 Gefitinib (ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.
特性 A potent EGFR tyrosine kinase inhibitor.
ターゲット
Tyr1173 (NR6W cells) [1] Tyr1173 (NR6wtEGFR cells) [1] Tyr992 (NR6wtEGFR cells) [1] Tyr992 (NR6W cells) [1]
26 nM 37 nM 37 nM 57 nM
体外試験

Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low-EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition. Gefitinib effectively blocks the phosphorylation of PLC-γ, with IC50 of 27nM, in NR6W cells. The NR6wtEGFR and NR6M cell lines has low levels of PLC-γ phosphorylation but the level in the NR6M cell line is more resistant to inhibition by Gefitinib with IC50 of 43 nM and 369 nM, respectively. Gefitinib inhibits Akt phosphorylations, with IC50 of 220 and 263nM, in the low-EGFR- and -EGFRvIII-expressing cell lines, respectively. Gefitinib in the dose range from 0.1 to 0.5μM significantly facilitates, rather than abrogates, colony formation of NR6M cells. However, at a concentration of 2 μM Gefitinib completely blocks NR6M colony formation. Gefitinib rapidly and in a dose-dependent manner inhibits EGFR and ERK phosphorylation up to 72 hours after EGF stimulation in both the high- and low-EGFR-expressing cell lines. [1] Gefitinib is the monolayer growth of these EGF-driven untransformed MCF10A cells with an IC50 of 20 nM. [2] The combination of Gefitinib (0.2 μM and 0.5 μM) with irradiation lead to a significant growth inhibition in LoVo cells, compared with radiation alone.. [3]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KB NHX6[Y5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwMEW0JO69VQ>? MoW5NVY2OTZ2N{O=
NIH3T3 NFW0U4pHfW6ldHnvckBCe3OjeR?= NHzRV3ExNjJizszN NH\rVlYzKGh? NUHrWFZKTE2VTx?= MV7Jcohq[mm2aX;uJI9nKEWJRjDzeIlufWyjdHXkJIh2dWGwIHXyZmIyKGG3dH;wbI9{eGixconsZZRqd25id3n0bEBKSzVyIH;mJFAvODF2NDFOwG0> M13pVVE3PDhyMki0
COS7 NWfSOoJJTnWwY4Tpc44hSXO|YYm= MlPqPVYh|ryP NE\WU2xKdmirYnn0bY9vKG:oIHj1cYFvKEqDS{KgWlYyP0ZibYX0ZY51KGW6cILld5Nm\A>? NUfSSGpPOTdzN{i3NlI>
A549 MUfDfZRwfG:6aXOgRZN{[Xl? MWO5OkBp NGHr[3RFVVOR NFHXSnBKSzVyPUGzMlU6KM7:TR?= NWjMbHBqOTh|MUO4NFc>
K562 NEXEXZlEgXSxdH;4bYMhSXO|YYm= M13uWVk3KGh? M1LFd2ROW09? M3LMcmlEPTB;OT6zOkDPxE1? NWiwW|RvOTh|MUO4NFc>
MDA-MB-231 NYPmZot4S3m2b4TvfIlkKEG|c3H5 MV:5OkBp NV3rNItmTE2VTx?= NWnEZmR{UUN3ME2zOk43OSEQvF2= MmHUNVg{OTN6MEe=
MOLT4 M4GzVGN6fG:2b4jpZ{BCe3OjeR?= MXi5OkBp NH\yVllFVVOR NWTSOHJwUUN3ME2xOU4xOiEQvF2= NE\KXJEyQDNzM{iwOy=>
MCF7 MlrJR5l1d3SxeHnjJGF{e2G7 NGS3cmY2OCEQvF2= M1XrdVczKGh? MUPJR|UxRTF{LkC1JO69VQ>? NELuPXgyQDd5MUixPS=>
BT474 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXLO|IhcA>? MYXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKWNEe0JINmdGy|IH;2[ZJmgHC{ZYPzbY5oKEWUQnKyJJdqfGhiRVO1NEBw\iByLkOg{txO NIjmUYQyQTB{OESyOC=>
HN5 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVq3NkBp MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiQNTDj[YxteyCxdnXy[ZhxemW|c3nu[{BGT0[UIIfpeIghTUN3MDDv[kAxNjBzIN88US=> NWrLcHZ4OTlyMki0NlQ>
BA/F3 MkizR5l1d3SxeHnjJGF{e2G7 NUflRVBZPzJiaB?= NX62NWh2S3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhSkFxRkOgZ4VtdHNiZYjwdoV{e2mwZzDFS2ZTKEx6NUjSJI12fGGwdDD3bZRpKEmFNUCgc4YhOC5yMUC4JO69VQ>? NWjQUnk4OTl{M{myNlk>
NIH3T3 M1LjV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHmRnQ2PzJiaB?= NUjDUXduT3Kxd4ToJIlvcGmkaYTpc44hd2ZibX;1d4UhVkmKL{PUN{Bk\WyuczDlfJBz\XO|aX7nJIVzSjJiZ3Xu[UB4cXSqIFnDOVAhd2ZiMD61OEDPxE1? M2L3[FE6PjZ3M{e3
MCF7 MX MkO4SpVv[3Srb36gRZN{[Xl? MYmzNEBucW5? M2ntZ2lvcGmkaYTpc44hd2ZiQlPSVEBmgHC{ZYPz[YQhf2m2aDDJR|UxKG:oIEGuNUDPxE1? MXyxPVk{Ojl4MB?=
A431 M{j3Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XET|ExKM7:TR?= M3f6U|czKGh? NFzQTGNIUTVyPUCuOVE1KM7:TR?= NUPDSZFoOTl7Nkm0OlU>
A431 NVrx[4tCU2mwYYPlJGF{e2G7 MX6wMlEh|ryP MWKxJIg> M3\XTGlvcGmkaYTpc44hd2ZiRVfGMYlv\HWlZXSgSWdHWiCyaH;zdIhwenmuYYTpc44> M1ryelE6QTZ7NE[1
A431 Mn7jT4lv[XOnIFHzd4F6 NXnafpZ6OTByIN88US=> NFLSbHkyOCCvaX6= NUDaUYg5WHKxbH;u[4VlKGmwaHnibZRwenliYXP0bZZqfHlib3[gSWdHNWmwZIXj[YQhTUeIUjDwbI9{eGixconsZZRqd25? MlfmNVk6Pjl2NkW=
Sf9 NHm5VYJMcW6jc3WgRZN{[Xl? MWixNEBucW5? MlnxSG1UVw>? NGL0ZnBKdmirYnn0bY9vKG:oIFXHSnIh\XiycnXzd4VlKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhemWlZYD0c5Ih[XW2b4Doc5NxcG:{eXzheIlwdiC5aYToJGlEPTBib3[gNE4xOzNizszN NX7udot{OjByNU[0NlU>
NCI-H1975 NFzLU2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrvXYE2KM7:TR?= MWW3NkBp M2n0PGlEPTB;OD6yOkDPxE1? NVjYWIVjOjBzNUG2O|A>
NCI-H1975 M1TKV2tqdmG|ZTDBd5NigQ>? NH7IR48yOCEQvF2= MVjJcohq[mm2aX;uJI9nKEWJRmKgZZV1d3Cqb4PwbI9zgWyjdHnvci=> NHTtTIMzODF3MU[3NC=>
NCI-H1975 MoDVSpVv[3Srb36gRZN{[Xl? MYGxNEDPxE1? MVvJcohq[mm2aX;uJI9nKEWUQlKyJIF2fG:yaH;zdIhwenmuYYTpc44> M3L1dFIxOTVzNkew
NCI-H1975 NVfz[mxETnWwY4Tpc44hSXO|YYm= NFTVNYI2KM7:TR?= NFzLR5k1QCCq MkK0TY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCjc4Pld5Nm\CCjczDhZ5RqfmG2aX;uJI9nKGOjc4Dhd4UuOw>? M4nr[lIxOTVzNkew
A375 M3LuVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfY[WNnPDhiaB?= NYrOPXJIUUN3ME2yNE42PSEQvF2= NEftRZAzODNyNEWzOy=>
SMMC7721 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVT4bWhoPDhiaB?= NHPhXVFKSzVyPUOzMlEzKM7:TR?= NEHNcWkzODNyNEWzOy=>
DU145 MnztR5l1d3SxeHnjJGF{e2G7 MUG1JIQ> MXfEUXNQ MVnJR|UxRTR{LkG3JO69VQ>? MXWyNFQ3PjV3NR?=
MIAPaCa2 MWrDfZRwfG:6aXOgRZN{[Xl? MlTOOUBl NEfGWFJFVVOR MVrJR|UxRTVyLk[yJO69VQ>? M3e0clIxPDZ4NUW1
PANC1 M3\1dWN6fG:2b4jpZ{BCe3OjeR?= NELJdmw2KGR? MljxSG1UVw>? NGXDXFlKSzVyPUSwMlQzKM7:TR?= NXzWNmxEOjB2Nk[1OVU>
PC9 NXrUbVZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3frVWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgSWdHWi2mZX\pZ4lmdnRiaIXtZY4hWEN7IHPlcIx{KHerdHigSWM2OCCxZjCwMlAyPyEQvF2= M4PJcFIyOjB6OECy
PC9 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlv5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDndo94fGhvcnXzbZN1[W62IHj1cYFvKFCFOTDj[YxteyCneIDy[ZN{cW6pIFXHSnIhTTd2Nm;BO|UxN1R5OUDNJI12fGGwdDD3bZRpKEWFNUCgc4YhPyEQvF2= NWrM[YZROjF{MEi4NFI>
PC3 NGHKc2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVuxNEDPxE1? NF\h[og4OiCq MmTYSG1UVw>? NGX3NlNKSzVyPUeuOEDPxE1? MkPvNlE{PTN3NE[=
MDA-MB-468 NFLYb5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTsNVAxKM7:TR?= Ml3FOFghcA>? MX7EUXNQ MkHPRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdIm= NVjQSodOOjF2Mkm2N|I>
Plasmodium falciparum NF\4cmpyUFSVIIDyc4ZqdGmwZzDmc5IhcW6qaXLpeI9zeyCxZjDQcIF{dW:maYXtJIZidGOrcHHyeY0heHKxbHnm[ZJifGmxbh?= NWWyU3Z6OjF6MUewOFU>
NCI-H1993 NYnMR5l1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HETVczKGh? NV6wSnViTE2VTx?= MWPJR|UxRTBwMTFOwG0> M1v4NFIyQTF4NEOz
NCI-H292 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrMO|IhcA>? M2e5NWROW09? MX3JR|UxRTBwMEKg{txO NWHMNpdmOjF7MU[0N|M>
A431 MYrLbY5ie2ViQYPzZZk> NGS2dFczKGh? NILjV5hFVVOR NGTLTYNKdmirYnn0bY9vKG:oIFXHSnIheGixc4Doc5J6dGG2aX;uJIlvKEWJRj3zeIlufWyjdHXkJIh2dWGwIFG0N|Ehf2m2aDDJR|UxKG:oIECuNFAyKM7:TR?= NWDmToRROjJzMEGxN|I>
MCF7 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWKxNFDDqM7:Zz;tUC=> NXjZWZJMPDhiaB?= M{fv[mROW09? MWTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNib4\ldoV5eHKnc4PpcochTUeIUjDn[Y5mKHerdHigTWM2OCCxZjCxNk4xPSEQvF2= NV3EXIp7OjJzMUmxN|A>
BT474 NVjhW48yS3m2b4TvfIlkKEG|c3H5 NV72eZZIOTBizszN MkjSOFghcA>? NWXFUGdIS3m2b4TvfIlkcXS7IHHnZYlve3Ric3XyeY0ue3Sjco\l[EBpfW2jbjDCWFQ4PCClZXzsdy=> MX[yNlE{QDNyOB?=
MCF7 NIPZ[mVEgXSxdH;4bYMhSXO|YYm= NWDRR|ZTOTBizszN Mn3iOFghcA>? MoX1R5l1d3SxeHnjbZR6KGGpYXnud5Qhe2W{dX2td5Rien[nZDDoeY1idiCPQ1[3JINmdGy|IH;2[ZIu\XiycnXzd4lv\yCHcnLCNkBk\Wyucx?= Mn62NlIyOzh|MEi=
HCC827 NV\FTlI5U2mwYYPlJGF{e2G7 NWnRTWlHOC5zMkWg{txO M{f6OVI1KGh? M4HEdWROW09? M1jQWGlvcGmkaYTpc44hd2ZiRVfGVkBl\WxiRUe0Ok1CPzVyIH31eIFvfCC\MUC2PEBifXSxcHjvd5Bpd3K7bHH0bY9v MYOyNlM{QTN2Mh?=
HCC827 MUjLbY5ie2ViQYPzZZk> MUiwMlEzPSEQvF2= MkHNNlQhcA>? MoDKSG1UVw>? M{\iU2lvcGmkaYTpc44hd2ZiRVfGVkBl\WxiRUe0Ok1CPzVyIH31eIFvfC2vZXTpZZRm\CCHcnugdIhwe3Cqb4L5cIF1cW:w MUGyNlM{QTN2Mh?=
HCC827 M4D0OWtqdmG|ZTDBd5NigQ>? M17aUFAvOTJ3IN88US=> NWfQVHpbOjRiaB?= M3j4ZWROW09? NVO3bWExUW6qaXLpeIlwdiCxZjDFS2ZTKGSnbDDFO|Q3NUF5NUCgcZV1[W62LX3l[IlifGWmIFHreEBxcG:|cHjvdplt[XSrb36= MVSyNlM{QTN2Mh?=
A431 MXHLbY5ie2ViQYPzZZk> MXexNFAh|ryP MUCzNEBucW5? MVPJcohq[mm2aX;uJI9nKEWJRmKg[IVzcX[nZDDmdo9uKGi3bXHuJGE1OzFiY3XscEBu\W2kcnHu[UBie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJBwdHlvR3z1MXR6eiCyaH;zdIhwenmuYYTpc44hf2m2aDDJR|UxKG:oIEGuNFgh|ryP NXztUYRsOjJ4OUi3PFI>
H460 NWnIWmNZS3m2b4TvfIlkKEG|c3H5 NX7nVWRyPzJiaB?= M4\aeGlEPTB;NT61PUDPxE1? MUCyNlczPzR2OR?=
HT-29 NGjKPVREgXSxdH;4bYMhSXO|YYm= NFLzVIY4OiCq MlHUTWM2OD1|LkO2JO69VQ>? MlHQNlI4Ojd2NEm=
SGC7901 M{O2PGN6fG:2b4jpZ{BCe3OjeR?= NFPTPY04OiCq MUnJR|UxRTFyLkK2JO69VQ>? MkfJNlI4Ojd2NEm=
A498 NXjVfllwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFf6R3RCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG0PVgh[2WubIOg[ZhxemW|c3nu[{BGT0[UIHHu[EBUWkNid3n0bEBKSzVyIH;mJFgvPiEQvF2= MYGyNlgyQDh2OB?=
Calu3 NELZXmFEgXSxdH;4bYMhSXO|YYm= M2XQSlExKM7:Zz;tUC=> M2WwVVczKGh? NGnVRo9KSzVyPUGuOkDPxE1? M1f0WVI{OTF4MU[4
FADU MnrIR5l1d3SxeHnjJGF{e2G7 MVexNEDPxGdxbVy= MVy3NkBp MVfJR|UxRTBwMEWg{txO NFu5VlQzOzFzNkG2PC=>
HCC827 MlzuR5l1d3SxeHnjJGF{e2G7 NXHmelA{OTBizsznM41N M{DCS|czKGh? NWjXd5p3UUN3ME2wMlAxOTVizszN NWHB[nR6OjNzMU[xOlg>
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IGROV-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\Cbm1KSzVyPUKuN|EzOzdizszN M{nIUHNCVkeHUh?=
JVM-3 NYfyTlk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PMVGlEPTB;Mj6zOFY1OyEQvF2= Mnu4V2FPT0WU
NCI-H2170 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILQ[XVKSzVyPUKuN|Q4QDNizszN MXPTRW5ITVJ?
EW-18 M4naVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTJTWM2OD1{LkO1OFcyKM7:TR?= MnK2V2FPT0WU
KU812 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3W0fmlEPTB;Mj6zOlc4QSEQvF2= M2\mZ3NCVkeHUh?=
NY NGS5U2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Ta[WlEPTB;Mj6zO|I4KM7:TR?= MX;TRW5ITVJ?
HTC-C3 M4nXSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnGzTWM2OD1{LkSyNlY4KM7:TR?= MmOyV2FPT0WU
CFPAC-1 NWe1VZFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnlTWM2OD1{LkSzPFY1KM7:TR?= NITpR5BUSU6JRWK=
HH MlvuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTwTWM2OD1{LkS5PFU1KM7:TR?= NGm4XnNUSU6JRWK=
MKN7 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTJwNkK3OFgh|ryP MlnOV2FPT0WU
TE-8 NXXMUpkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEj3VIVKSzVyPUKuOlM3PTNizszN M4SxTHNCVkeHUh?=
MC-IXC M4PPUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{foT2lEPTB;Mj62OFQ2OyEQvF2= NHjITW9USU6JRWK=
DMS-79 M1n3WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2D2XWlEPTB;Mj62PVI5PCEQvF2= M2\Yd3NCVkeHUh?=
Detroit562 Mm\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXoXnVsUUN3ME2yMlY6QDR3IN88US=> MW\TRW5ITVJ?
HuP-T4 NVjoe|FyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPsbIh5UUN3ME2yMlczQDF6IN88US=> MUPTRW5ITVJ?
QIMR-WIL MnHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTJwN{W5OVIh|ryP M1LqfnNCVkeHUh?=
BB65-RCC M{TEN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2P0N2lEPTB;Mj64NFcyOyEQvF2= MYrTRW5ITVJ?
PC-3 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mon3TWM2OD1{LkizN|E4KM7:TR?= NFvWOoFUSU6JRWK=
OVCAR-3 MkH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2W5WmlEPTB;Mj64OVU6PCEQvF2= M2SzZXNCVkeHUh?=
KYSE-510 M3HjfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXBTWM2OD1{Lki2O|g3KM7:TR?= NFHU[oRUSU6JRWK=
HC-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTrZ|NNUUN3ME2yMlk1ODF{IN88US=> MUfTRW5ITVJ?
NCI-H1693 NUjs[Vg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTJwOUW4PVch|ryP MYPTRW5ITVJ?
DU-4475 NYO4W4xET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TPVWlEPTB;Mj65PVA2OiEQvF2= NEXTVXdUSU6JRWK=
COLO-680N Mlu1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnyxTWM2OD1|LkCwOFk2KM7:TR?= MlnVV2FPT0WU
MN-60 Mor4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojVTWM2OD1|LkC0PVc1KM7:TR?= NFjP[4FUSU6JRWK=
BCPAP MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PDU2lEPTB;Mz6wPFI6PSEQvF2= NVvucIxrW0GQR1XS
647-V NEH0RlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rLRmlEPTB;Mz6xOlIzKM7:TR?= NYTkV|ZLW0GQR1XS
HT-1376 NYnQ[ZhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\xTWM2OD1|LkKwOVA3KM7:TR?= MWPTRW5ITVJ?
NCI-H1793 MmXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXVTWM2OD1|LkKxNFk5KM7:TR?= M2j0PXNCVkeHUh?=
SW1463 NH;hNHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTNwMk[xPVIh|ryP NYmzZ2F5W0GQR1XS
NCI-H727 M17McGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\LOGlEPTB;Mz6zPFU5PCEQvF2= M4LBZXNCVkeHUh?=
LB771-HNC MmfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTNwM{mxNlYh|ryP NFPoeIpUSU6JRWK=
D-542MG MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\pd3FKSzVyPUOuOFQzOjJizszN NVTKUYN1W0GQR1XS
NTERA-S-cl-D1 MkHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7zTWM2OD1|LkS0PVU4KM7:TR?= Mo\4V2FPT0WU
C8166 NVvFbZlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HSWmlEPTB;Mz60OlUzOSEQvF2= NF;wSVNUSU6JRWK=
639-V M1fXTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTNwNUe3PVIh|ryP MWXTRW5ITVJ?
TE-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7CWlZKUUN3ME2zMlU6OTZ7IN88US=> NHfDNnZUSU6JRWK=
OAW-28 NV;IN4Y4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTNwNUm0NlYh|ryP NWnKRXI2W0GQR1XS
SK-LU-1 NYTZfG9rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTNwNkC2OFUh|ryP MWLTRW5ITVJ?
CaR-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYH0O|R4UUN3ME2zMlYyODR6IN88US=> NFzLXFFUSU6JRWK=
A2780 M37KRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDQTWM2OD1|Lk[0NFg6KM7:TR?= NUnqdW94W0GQR1XS
C2BBe1 NFHmU3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7sbIxmUUN3ME2zMlY1PDB5IN88US=> M3vYZXNCVkeHUh?=
SK-MES-1 NYCwe5BpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTNwNkS2NVQh|ryP NIjr[2JUSU6JRWK=
PANC-10-05 M2nRbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPuNHZKSzVyPUOuO|IxPzJizszN M2DNNnNCVkeHUh?=
J-RT3-T3-5 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3W5W2lEPTB;Mz63OVQxPiEQvF2= NYPVO3BXW0GQR1XS
ES4 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYW0cHlkUUN3ME2zMlgzOjh4IN88US=> NXrVS5FXW0GQR1XS
NCI-H28 MnXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDLSo9nUUN3ME2zMlgzQTZzIN88US=> NHj6V3RUSU6JRWK=
NCI-H1155 NXXMVVVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTNwOESxOVkh|ryP NYexT2VwW0GQR1XS
KURAMOCHI MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37GTmlEPTB;Mz64OlA2PiEQvF2= MXHTRW5ITVJ?
NCI-H69 NH\Mc|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDvTlBKSzVyPUOuPVAyPzhizszN M{j0VnNCVkeHUh?=
IST-MES1 NFmwW2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTIc5dKSzVyPUOuPVQxOjlizszN M2jPenNCVkeHUh?=
NH-12 NHf2dm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkf4TWM2OD1|Lkm0NVg4KM7:TR?= MmrPV2FPT0WU
JVM-2 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXL3fmN1UUN3ME2zMlk1PzV{IN88US=> MXfTRW5ITVJ?
EW-16 NVT4WmlST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3L6VmlEPTB;Mz65OVU4PyEQvF2= NX;C[GtrW0GQR1XS
NCI-H441 NWPRemUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2n0cmlEPTB;Mz65O|AyPCEQvF2= NX7mellHW0GQR1XS
RCC10RGB NF7XPHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEGwdFBKSzVyPUSuNFEzPDZizszN MYrTRW5ITVJ?
TCCSUP Mki2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzQTWM2OD12LkGxNFUh|ryP NYr4WlYyW0GQR1XS
HL-60 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHYXYlwUUN3ME20MlEzOjRzIN88US=> NIHTXYZUSU6JRWK=
EW-11 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWe4RYZSUUN3ME20MlE{OjZzIN88US=> MVnTRW5ITVJ?
KARPAS-299 Mn3ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH6zWWxKSzVyPUSuN|ExOTNizszN MYnTRW5ITVJ?
SNU-C2B NV3hRWc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHBXJBKSzVyPUSuN|Q3QDZizszN M1nQRXNCVkeHUh?=
LU-139 NVr3O5QzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzremlKSzVyPUSuN|czPDdizszN NVvx[YxvW0GQR1XS
HCC1937 M3e1[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LMcGlEPTB;ND6zO|k6OyEQvF2= Mn\FV2FPT0WU
GR-ST M33jPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPHTWM2OD12LkSzNVgh|ryP NXi5UYhKW0GQR1XS
SK-OV-3 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnH0TWM2OD12LkS2NFQzKM7:TR?= NWHWXJh6W0GQR1XS
A172 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPH[Y9KSzVyPUSuOVU2OjFizszN NFfWOVBUSU6JRWK=
NB10 M4rCSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MliwTWM2OD12LkW5O|gyKM7:TR?= NYn3enl3W0GQR1XS
P30-OHK MoDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVK3bXR1UUN3ME20MlgyQTJ7IN88US=> MoS2V2FPT0WU
KYSE-520 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTRwOEiwNVgh|ryP MmPHV2FPT0WU
KNS-62 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rCTmlEPTB;ND65NFgxPyEQvF2= M3f6bXNCVkeHUh?=
ES1 NGnZR2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDJXmJKSzVyPUSuPVYxOzVizszN NGTuNFlUSU6JRWK=
KOSC-2 M1vKTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXOd2RKSzVyPUSuPVk6PTlizszN MY\TRW5ITVJ?
TE-9 NEfZ[2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7rfG5PUUN3ME21MlAyPTJ3IN88US=> NV;W[5pQW0GQR1XS
NCI-H1838 NXjmeYNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXwXIhKSzVyPUWuNFIxPzZizszN NHu3e3dUSU6JRWK=
KP-N-YN NF3xR|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TrNWlEPTB;NT6xNlU6OSEQvF2= MXnTRW5ITVJ?
ALL-PO NUX4WnNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvkTWM2OD13LkKyOVg4KM7:TR?= NYezNWx1W0GQR1XS
NOMO-1 M2qzbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml:1TWM2OD13LkKzNVc3KM7:TR?= NUDrcGVJW0GQR1XS
CGTH-W-1 MlftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTVwM{i1PFQh|ryP MWHTRW5ITVJ?
ATN-1 MkS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3iyc2lEPTB;NT60NVE5PCEQvF2= NWjXeJpnW0GQR1XS
AGS NWLZO49ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nvWmlEPTB;NT60PVYyQCEQvF2= NYj3eVVxW0GQR1XS
SW13 NETWZ4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTVwNUOyOlUh|ryP NY\tXYdZW0GQR1XS
SW1990 MmH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HCfWlEPTB;NT62NlI5PSEQvF2= NWXXUGI4W0GQR1XS
BFTC-905 M1zpPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHsTWM2OD13Lk[1PFc5KM7:TR?= MVLTRW5ITVJ?
RMG-I Mk\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnxXVVKSzVyPUWuOlU6PDJizszN NGrKTmFUSU6JRWK=
HD-MY-Z MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nMTGlEPTB;NT62PFU5OSEQvF2= NHi4ZYFUSU6JRWK=
HCC1187 NETZdldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTVwN{GwN|Ih|ryP NHHuZY5USU6JRWK=
HCC2998 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7KTWM2OD13LkexPFc4KM7:TR?= NWPBTG1WW0GQR1XS
RT-112 M1nVd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1qySmlEPTB;NT65NFI1PSEQvF2= MnflV2FPT0WU
CAKI-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGi4OHZKSzVyPU[uNFA6QDVizszN M3frXnNCVkeHUh?=
HDLM-2 NH7mXVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTFUIVrUUN3ME22MlAyPDh7IN88US=> NXjiVGV4W0GQR1XS
TE-10 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfpeFBKSzVyPU[uNFQ5OzNizszN MVfTRW5ITVJ?
KE-37 MoHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vO[GlEPTB;Nj6wO|I2QCEQvF2= M1PjTXNCVkeHUh?=
RCM-1 NWjJS2FST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTZwMEe3NVkh|ryP M4i0eHNCVkeHUh?=
Mewo MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTZwMUG0PFch|ryP M2PJZ3NCVkeHUh?=
L-428 Mmq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTZwMUiwN|ch|ryP MXLTRW5ITVJ?
8-MG-BA MkS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTZwMUmzO|kh|ryP M4HSWXNCVkeHUh?=
SK-MEL-28 NWfXco5HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfETWM2OD14LkKwPVY4KM7:TR?= M3zqdXNCVkeHUh?=
VA-ES-BJ MmjKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTZwM{C0OlIh|ryP MX\TRW5ITVJ?
CAL-120 MmTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{T1e2lEPTB;Nj60OVE3OiEQvF2= MkLqV2FPT0WU
GAMG Mn65S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnodIRKSzVyPU[uOVA3OiEQvF2= Ml\iV2FPT0WU
MSTO-221H M4\IS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\wS2dKSzVyPU[uOVEyPyEQvF2= MnrTV2FPT0WU
GCT NXjDS25zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3hXWlKSzVyPU[uOVM{QDdizszN MmDJV2FPT0WU
SH-4 M3\zXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4n2TmlEPTB;Nj61PFg1PCEQvF2= M2O4WXNCVkeHUh?=
Calu-3 NF3McWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fJe2lEPTB;Nj62OVU3QCEQvF2= NW\IUY9mW0GQR1XS
SK-HEP-1 NV\tepNrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnp[lY3UUN3ME22MlcyPzV|IN88US=> NHXoXVlUSU6JRWK=
PFSK-1 NXL4SI1VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnwfVA4UUN3ME22Mlc{PDd6IN88US=> MonVV2FPT0WU
NB12 M1izRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTWNm9kUUN3ME22Mlc5PDB2IN88US=> NHHEVFJUSU6JRWK=
A388 NH3PRmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;JOXpKSzVyPU[uPFk2OiEQvF2= MWXTRW5ITVJ?
KLE NU\BUXNtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFOwNFJKSzVyPU[uPVY2OTZizszN MU\TRW5ITVJ?
TE-11 MlSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTdwMES5Olch|ryP NYD1OGNUW0GQR1XS
NCI-H2405 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3LV5VKSzVyPUeuNFg{QTNizszN NE\hNWlUSU6JRWK=
OVCAR-4 NXzZfXhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Sy[2lEPTB;Nz6xOVM2KM7:TR?= M{jwSXNCVkeHUh?=
KP-N-YS MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXw[2dKSzVyPUeuNVgyPCEQvF2= M2XPZ3NCVkeHUh?=
NOS-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoH6TWM2OD15LkK1PFI5KM7:TR?= NWThUYxGW0GQR1XS
DMS-114 NEm1bJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTdwMkm2N|Eh|ryP NUfvUGFjW0GQR1XS
NCI-H2030 NEnmOlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHRTWM2OD15LkOzOlk5KM7:TR?= NF72S2JUSU6JRWK=
HEL M2rxXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jxWmlEPTB;Nz6zO|UzOSEQvF2= NVPneZh7W0GQR1XS
CAL-62 NX[2VnBXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIH3OI9KSzVyPUeuN|k5PjZizszN MXPTRW5ITVJ?
COLO-668 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX2yOIJtUUN3ME23MlQ{QTZ5IN88US=> NYD1NHFkW0GQR1XS
SKG-IIIa NEfzXY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nR[2lEPTB;Nz60OVM5OSEQvF2= NGrkXo5USU6JRWK=
HCC1419 MojzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrOTWM2OD15LkS2PFM{KM7:TR?= MVPTRW5ITVJ?
OS-RC-2 M1TCW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTdwNEm4PVQh|ryP MmW5V2FPT0WU
COLO-829 NYC3NHF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3u2U2lEPTB;Nz62OlQ3OyEQvF2= M1f2THNCVkeHUh?=
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NCI-H810 MlrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTFyLkG1PVch|ryP M{\pb3NCVkeHUh?=
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RPMI-7951 NVTu[2pLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrwOnlvUUN3ME2xNU43OzR6IN88US=> M4LqNnNCVkeHUh?=
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SK-PN-DW MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljjTWM2OD1zMz64OFI4KM7:TR?= M124OnNCVkeHUh?=
KALS-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTiTWM2OD1zMz64OVI2KM7:TR?= NXfhbYZyW0GQR1XS
LAN-6 NWmyco5RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFj3SZpKSzVyPUG0MlI2OyEQvF2= MnXZV2FPT0WU
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NCI-H630 M4PJZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnuZXlFUUN3ME2xOE46PDZ5IN88US=> NFKwfWNUSU6JRWK=
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NCI-H1755 MmjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfKTWM2OD1zND65PVU{KM7:TR?= M4PHXXNCVkeHUh?=
MOLT-4 NUK2SpFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\oWW45UUN3ME2xOU4xPDl5IN88US=> MkH2V2FPT0WU
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UMC-11 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHjSW9KSzVyPUG1Mlc2OjNizszN M{nYO3NCVkeHUh?=
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NCI-H23 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTF3Lki0N|gh|ryP Mn;NV2FPT0WU
HuCCT1 NFjxfYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{W4b2lEPTB;MUWuPFc1KM7:TR?= MWPTRW5ITVJ?
MPP-89 NV;Gc4ZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTpTWM2OD1zNT65OFE4KM7:TR?= MoP4V2FPT0WU
HT55 NI[1[YhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojDTWM2OD1zNT65OFc5KM7:TR?= MYnTRW5ITVJ?
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GP5d Mn25S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmm3TWM2OD1zNj6yNVg4KM7:TR?= MVjTRW5ITVJ?
BHT-101 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF71N4dKSzVyPUG2MlI1OzlizszN M1nTUXNCVkeHUh?=
M059J MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHKTWM2OD1zNj6yPFQh|ryP NX2wT3BHW0GQR1XS
D-283MED NIPrSHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3QfopXUUN3ME2xOk41OjB7IN88US=> MmfBV2FPT0WU
BEN NIfGbZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfWS5JDUUN3ME2xOk42OTV3IN88US=> NIr1VnJUSU6JRWK=
LB373-MEL-D NHTne2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TwZ2lEPTB;MU[uO|I{OiEQvF2= MULTRW5ITVJ?
MEL-HO Ml;OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\6SmlEPTB;MU[uPFg2PCEQvF2= M4HTdnNCVkeHUh?=
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NCI-H1573 Mm\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTF5LkK4NlYh|ryP MVLTRW5ITVJ?
NCI-H1581 NXvvbJU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3WRoxyUUN3ME2xO{41PDFzIN88US=> NYrzb4M6W0GQR1XS
NCI-H747 NVWwTJBPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTF5LkWyPVch|ryP MlnMV2FPT0WU
SW1783 MoHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX75So1wUUN3ME2xO{43PDF3IN88US=> M1u5UnNCVkeHUh?=
Calu-6 NGf6WHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHWVWdHUUN3ME2xO{43Pzh{IN88US=> MUjTRW5ITVJ?
SF268 NUj0dmd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLBRmpiUUN3ME2xO{43QTZ7IN88US=> NGe1N4tUSU6JRWK=
ES8 MnnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1qz[GlEPTB;MUeuPFU6OyEQvF2= M1TZdHNCVkeHUh?=
KM-H2 NHnIWIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTF5Lkm0NVEh|ryP NUTyflNlW0GQR1XS
D-502MG MkHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjXVlRKSzVyPUG3Mlk5ODhizszN NYPxTG1IW0GQR1XS
HLE NFPvRnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1e2SmlEPTB;MUiuN|E1QCEQvF2= Mli4V2FPT0WU
SW982 M2nhNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rSemlEPTB;MUiuOFA4PSEQvF2= NVPRXFVtW0GQR1XS
MDA-MB-361 MmPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnJc4N{UUN3ME2xPE42PTh6IN88US=> NES2doRUSU6JRWK=
NCI-H1563 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTF6LkexNlQh|ryP MWfTRW5ITVJ?
MFE-280 MmPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7ZTWM2OD1zOD63Nlk{KM7:TR?= NXPlc4NjW0GQR1XS
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NB14 NIHzbG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHXVHg6UUN3ME2zPE41PTR2IN88US=> MkLxV2FPT0WU
D-423MG NG[1RW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3:1R2lEPTB;M{iuOFg3QSEQvF2= MXvTRW5ITVJ?
NCI-H510A MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\IR4pUUUN3ME2zPE43PDVzIN88US=> NYjlV2hVW0GQR1XS
NMC-G1 M{PyPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTN6LkeyNlIh|ryP NXP5eFcyW0GQR1XS
SW948 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzF[nRKSzVyPUO4Mlg6PDlizszN NULXc3BYW0GQR1XS
MFM-223 NU\jU41HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnVdJBKSzVyPUO4Mlk1OzFizszN NFKyT3VUSU6JRWK=
PAN1 NV\ReoQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTN6Lkm5NVkh|ryP M4L3WHNCVkeHUh?=
MZ7-mel Mk[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4GwN2lEPTB;M{muNVE6QSEQvF2= MUHTRW5ITVJ?
COLO-679 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2j2V2lEPTB;M{muPVcxQCEQvF2= NF3McHZUSU6JRWK=
SW872 NEjlPZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkX6TWM2OD12MD6yNFMyKM7:TR?= NIW5em1USU6JRWK=
HT-1197 NVi1N|lwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk[zTWM2OD12MD6yPFY6KM7:TR?= MljSV2FPT0WU
ES6 NECwRlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLNTWM2OD12MD60OVUzKM7:TR?= Mnm2V2FPT0WU
SNU-387 Ml;DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfDTWM2OD12MD64NlM5KM7:TR?= MYXTRW5ITVJ?
T47D MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUmzXHBjUUN3ME20NU4xOTl{IN88US=> NUjWZ2J[W0GQR1XS
G-402 NGntOXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mne4TWM2OD12MT6wPFA6KM7:TR?= NFvmNWRUSU6JRWK=
MZ1-PC MnjUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TMN2lEPTB;NEGuPFEh|ryP MmPjV2FPT0WU
SW1417 NYrvZZJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInsdFlKSzVyPUSyMlMxOyEQvF2= NXvQOpI1W0GQR1XS
RERF-LC-MS MlLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHP0dYxKSzVyPUSyMlUxQDdizszN NIW0cnZUSU6JRWK=
SF539 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fRdmlEPTB;NEKuOVUzQSEQvF2= M4frV3NCVkeHUh?=
ESS-1 MmPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{O2RWlEPTB;NEOuOVU2QCEQvF2= NFv0SXJUSU6JRWK=
RO82-W-1 M2THdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTR|Lk[xOVMh|ryP NXrR[JFJW0GQR1XS
S-117 MlPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTR|Lk[5OVgh|ryP M33kXnNCVkeHUh?=
SW756 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjVZWgyUUN3ME20N{45OjR{IN88US=> MWjTRW5ITVJ?
CP66-MEL NEDHZpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlz2TWM2OD12NT63NVQ{KM7:TR?= NH7ISW1USU6JRWK=
H-EMC-SS MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;6TWM2OD12NT63Olk{KM7:TR?= MWnTRW5ITVJ?
NCI-H2052 NV;6XINkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHC[XhKSzVyPUS1MlkxOjdizszN Mn;hV2FPT0WU
SW684 Moj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTR5LkCwPFEh|ryP NG\kdG9USU6JRWK=
HCC1569 NGPIUVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWCxN5N4UUN3ME20O{4yPjV6IN88US=> NXHxT5Y2W0GQR1XS
KGN MnS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIewV3NKSzVyPUS3MlM{OTFizszN M3zRfXNCVkeHUh?=
LCLC-103H M2TP[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4T0U2lEPTB;NEeuOFQxPCEQvF2= M1PRcHNCVkeHUh?=
SW780 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjXWGtKSzVyPUS3MlY{PTFizszN Ml7sV2FPT0WU
NCI-H1703 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTWUm9{UUN3ME20PE4{OzV{IN88US=> MWjTRW5ITVJ?
HCC1395 NIHDW3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrnOnVKSzVyPUS4Mlc1OzJizszN M1zONnNCVkeHUh?=

多くの細胞株試験データを見る場合、クリックしてください

体内試験 Gefitinib (100 mg/kg) improves the anti-tumor effect of radiotherapy in LoVo tumor xenografts. [3] Gefitinib treatment of nude mice bearing established human GEO colon cancer xenografts reveals a reversible dose-dependent inhibition of tumor growth because GEO tumors resumes the growth rate of controls at the end of the treatment. [4]

お薦めの試験操作(参考用のみ)

細胞試験: [1]
+ 展開
  • 細胞株: NR6, NR6M and NR6W cells
  • 濃度: 0-2 μM
  • 反応時間: 72 hours
  • 実験の流れ: Exponentially growing cells including NR6, NR6M, NR6M and NR6W cells are seeded in sextuple in 96-well plates at a concentration of 2000 cells/well, allowed to adhere and subsequently washed in PBS and incubated overnight in medium containing 0.5% FCS. Cells are then treated with varying concentrations (0-2 μM) of Gefitinib or the solute control DMSO and EGF. The optimal EGF concentration for inducing proliferation of NR6wtEGFR and NR6W cells has previously been determined and hence NR6wtEGFR and NR6W cells are supplemented with 10 nM and 0.1 nM EGF, respectively. EGF is not added to NR6 and NR6M cells. After 72 hours the amount of cells are measured by performing a MTT proliferation assay.
    (参考用のみ)
動物試験:[3]
+ 展開
  • 動物モデル: Female nude mice (cba nu/nu) aged 8–10 weeks are intra-dermal injected with LoVo cells.
  • 製剤: 0.5% polysorbate
  • 投薬量: 100 mg/kg
  • 投与方法: Once daily by oral administration (0.1 mL/10 g body weight) for 14 days
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 89 mg/mL (199.14 mM)
Ethanol 4 mg/mL (8.95 mM)
Water Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます:
1% CMC Na
混合させたのち直ちに使用することを推奨します。
30mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 446.90
化学式

C22H24ClFN4O3

CAS No. 184475-35-2
保管
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03050164 Completed Bioequivalence Study Hunan Kelun Pharmaceutical Co., Ltd. September 8, 2016 Phase 1
NCT02856893 Not yet recruiting NSCLC European Organisation for Research and Treatment of Cancer - EORTC|AstraZeneca March 2017 Phase 2
NCT02976116 Recruiting NSCLC Hutchison Medipharma Limited December 2016 Phase 2
NCT02951637 Not yet recruiting Lung Adenocarcinoma Shanghai Chest Hospital|Ruijin Hospital|Changhai Hospital December 2016 Phase 2
NCT02930954 Not yet recruiting Non-small-cell Lung Cancer Caicun Zhou|Tongji University November 2016 Phase 2
NCT02929693 Enrolling by invitation Cancer Shanghai University of Traditional Chinese Medicine|Shanghai Chest Hospital|Shanghai Pulmonary Hospital, Shanghai, China October 2016 Phase 3

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    I try to dissolve Gefitinib (ZD1839) in 0.5% methylcellulose+0.2% Tween 80 for in vivo experiments. However, when I prepare the mixture, it forms precipitates. Exists another way to dissolve completely the compound?

  • 回答:

    S1025 can be dissovled in both 5% DMSO+corn oil and 5% DMSO+30% PEG 300+5% Tween 80+ddH2O at 2.5 mg/ml clearly. It dissolves in DMSO not readily, please sonicate and warm it in water bath at about 45 degree, and dissolve it clearly first. Then add other solvent.

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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID