DNA/RNA Synthesis

DNA/RNA Synthesis製品

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S1166 Cisplatin シスプラチン (Cisplatin (NSC 119875, Cisplatinum, cis-diamminedichloroplatinum II, CDDP, cis DDP, DDP)) は無機白金錯体であり、腫瘍細胞中において DNA 付加物を形成することにより DNA 合成を阻害する能力を有します。シスプラチンはフェロトーシス (ferroptosis) を活性化し、オートファジー (autophagy) を誘導します。溶液は都度調製してください。DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.Solutions are unstable and should be fresh-prepared.
Nat Commun, 2024, 15(1):866
Clin Cancer Res, 2024, 30(1):187-197
Cancer Lett, 2024, 586:216695
S7418 Cycloheximide Cycloheximide, an antifungal antibiotic, is an eukaryote protein synthesis inhibitor with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively. Cycloheximide suppresses ferroptosis and inhibits autophagy.Solutions are unstable and should be fresh-prepared.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
Bioact Mater, 2024, 32:277-291
Nat Commun, 2024, 15(1):1282
Exp Mol Med, 2024, 56(1):177-191
S1714 Gemcitabine Gemcitabine, a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy. Gemcitabine induces a potent p53-dependent apoptosis.
Nat Commun, 2024, 15(1):1287
Genes Dis, 2024, 11(1):430-448
iScience, 2024, 27(1):108667
S1209 5-FU (5-Fluorouracil) 5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.
NPJ Precis Oncol, 2024, 8(1):52
Am J Cancer Res, 2024, 14(1):378-389
Frontiers, 2024, 10.3389/978-2-8325-4184-5
S1224 Oxaliplatin Oxaliplatin is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells.Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
Mol Cancer, 2024, 23(1):23
Gastroenterology, 2024, S0016-5085(24)00062-3
NPJ Precis Oncol, 2024, 8(1):52
S1237 TMZ(Temozolomide) テモゾロミド (Temozolomide (NSC 362856,TMZ,CCRG 81045,Methazolastone)) はDNA 環上の窒素原子と環外酸素を修飾することが可能な単官能性 SN1 アルキル化剤であり、中間体である MTIC を経て、活性代謝産物であるメチルジアゾニウムカチオン (methyl diazoniumcation) に分解されると、生理学的 pH において DNA にメチル基を転移します。テモゾロミドはアポトーシス (apoptosis) を誘発し、抗がん活性を呈します。L-1210 細胞および L-1210/BCNU 細胞における DNA 損傷誘導剤です。
Cancer Cell Int, 2024, 24(1):36
bioRxiv, 2024, 2024.01.20.576487.
Research Square, 2024, 10.21203/rs.3.rs-3886648/v1
S1491 Fludarabine Fludarabine is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis.
Nat Commun, 2024, 15(1):1718
Cell Rep Med, 2024, 5(2):101420
Mol Ther Nucleic Acids, 2024, 35(1):102125
S1149 Gemcitabine HCl ゲムシタビン塩酸塩 (Gemcitabine (LY-188011, NSC 613327) HCl) は DNA 合成阻害剤であり、 PANC1 細胞、 MIAPaCa2 細胞、 BxPC3 細胞および Capan2 細胞における IC50 はそれぞれ 50 nM, 40 nM, 18nM, 12 nM です。
Int J Biol Sci, 2024, 20(4):1389-1409
Phytomedicine, 2024, 155377
Neoplasia, 2024, 47:100951
S1215 Carboplatin Carboplatin is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells.Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
Clin Cancer Res, 2024, 30(1):187-197
Int J Mol Sci, 2024, 25(2)886
Nat Commun, 2023, 14(1):4057
S1214 Bleomycin sulfate ブレオマイシン硫酸塩 (Bleomycin Sulfate (NSC125066)) はグリコペプチド系抗生物質であり、また扁平上皮癌 (SCC) に対する抗がん活性物質でもあります。UT-SCC-19A 細胞における IC50 は 4 nM です。
Nat Commun, 2024, 15(1):1429
EMBO J, 2024, 43(1):61-86
J Ethnopharmacol, 2024, 318(Pt B):116983
S8146 Mitomycin C Mitomycin C (Ametycine) is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
Clin Transl Med, 2024, 14(2):e1586
Stem Cell Res Ther, 2024, 15(1):26
Burns Trauma, 2024, 12:tkad058
S1117 Triciribine (API-2) Triciribine (API-2) is a DNA synthesis inhibitor, also inhibits Akt in PC3 cell line and HIV-1 in CEM-SS, H9, H9IIIB, U1 cells with IC50 of 130 nM and 20 nM, respectively; does not inhibit PI3K/PDK1; 5000-fold less active in cells lacking adenosine kinase. Phase 1/2.
J Cell Sci, 2023, 136(4)jcs259788
Exp Gerontol, 2023, 173:112091
EJHaem, 2023, 4(3):631-638
S8932 Remdesivir (GS-5734) Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV.
Int J Mol Sci, 2024, 24;25(3):1427.
Nature, 2023, 613(7944):558-564
Cell, 2023, 186(4):850-863.e16
S1648 Cytarabine Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis.
iScience, 2024, 27(1):108667
Int J Mol Sci, 2024, 25(1)646
Cell Signal, 2024, 114:111004
S8964 Actinomycin D (Dactinomycin) Actinomycin D (Dactinomycin, Act D, RASP-101) is a significant polypeptide antibiotic isolated from soil bacteria of the genus Streptomyces. Actinomycin D (Dactinomycin) inhibits DNA repair and rests the cell cycle at G1 phase with IC50 of 0.42 μM and 0.4 nM, respectively. Actinomycin D is an autophagy activator, induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
Cell Mol Life Sci, 2024, 81(1):92
NPJ Precis Oncol, 2024, 8(1):22
Signal Transduct Target Ther, 2023, 8(1):63
S3035 Daunorubicin HCl Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis.
Cell Stem Cell, 2023, 10.1016/j.stem.2023.09.011
Int J Mol Sci, 2023, 24(16)12926
Cancers (Basel), 2023, 15(12)3112
S2684 Pidnarulex (CX-5461) Pidnarulex (CX-5461) is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.
Sci Rep, 2024, 14(1):4060
PLoS One, 2024, 19(1):e0295629
Exp Ther Med, 2024, 27(3):107.
S1229 Fludarabine Phosphate Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.
J Biomed Sci, 2022, 29(1):20
J Neuroinflammation, 2022, 19(1):109
Int J Biol Sci, 2022, 18(1):331-348
S1135 Pemetrexed disodium Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
Cancer Cell, 2022, 40(10):1128-1144.e8
Cell Rep, 2022, 38(9):110448
Front Pharmacol, 2022, 13:1032975
S1896 Hydroxyurea Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. Hydroxyurea activates apoptosis and autophagy. Hydroxyurea is used to treat HIV infection.
bioRxiv, 2024, 10.1101/2024.01.04.574133
Cell Rep, 2023, 42(7):112660
Cell Rep, 2023, 42(10):113176
S2794 Sofosbuvir Sofosbuvir is a HCV NS5B polymerase inhibitor for the treatment of chronic hepatitis C virus (HCV) infection.
mBio, 2023, 10.1128/mbio.01318-23
Commun Biol, 2023, 6(1):511
Nat Commun, 2022, 13(1):2079
S1212 Bendamustine HCl Bendamustine HCl is a DNA-damaging agent with IC50 of 50 μM in cell-free assay.
Cell Death Discov, 2023, 9(1):39
Front Immunol, 2022, 13:1045710
J Pers Med, 2022, 12(2)258
S7742 SCR7 SCR7 is a specific DNA Ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ).
iScience, 2024, 27(2):108814
Nat Commun, 2023, 14(1):4761
Mol Ther Nucleic Acids, 2023, 31:309-323
S2239 Tubacin Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1. Tubacin reduces the replication of the Japanese Encephalitis Virus via the decrease of viral RNA synthesis.
Br J Cancer, 2023, 10.1038/s41416-023-02195-0
Int J Mol Sci, 2023, 24(5)4720
Oncogene, 2022, 10.1038/s41388-022-02236-7
S1156 Capecitabine Capecitabine is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis.
Genes Dis, 2024, 11(1):430-448
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
S5971 Pemetrexed Pemetrexed (LY231514) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
Mol Cancer Res, 2024, 22(1):82-93
Amino Acids, 2024, 56(1):15
Cell Death Dis, 2023, 10.1038/s41419-023-06240-x
S1373 Daptomycin Daptomycin is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms.
Molecules, 2023, 28(2)621
Infect Drug Resist, 2023, 16:4867-4879
Infect Drug Resist, 2023, 16:4867-4879
S1199 Cladribine Cladribine is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.
Exp Hematol Oncol, 2023, 12(1):23
Neurol Neuroimmunol Neuroinflamm, 2023, 10(5)e200149
Am J Cancer Res, 2023, 13(2):355-378
S7419 Blasticidin S HCl Blasticidin S HCl is a nucleoside antibiotic isolated from Stretomyces girseochromogenes. It acts by blocking hydrolysis of peptidyl-tRNA induced by release factors and inhibits peptide bond formation. It is used to select transfected cells carrying bsr or BSD resistance genes.
Nat Commun, 2023, 10.1038/s41467-023-42850-x
Nat Commun, 2023, 14(1):2978
Nat Commun, 2023, 14(1):6473
S5582 Cytarabine hydrochloride Cytarabine is a pyrimidine nucleoside analog that is used mainly in the treatment of leukemia. It is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA.
Blood, 2022, blood.2022016090
Clin Transl Med, 2022, 12(2):e722
Front Pharmacol, 2022, 13:1032975
S7975 Favipiravir (T-705) Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.
J Med Virol, 2024, 96(1):e29372
Nat Commun, 2022, 13(1):2256
Nucleic Acids Res, 2022, gkac512
S3190 m6A (N6-methyladenosine) m6A (N6-methyladenosine) は、アデノシンのベース変更された類似体で、天然RNAの中のマイナーなヌクレオシドとして見つかります。
Biosci Rep, 2024, 44(1)BSR20231430
Nucleic Acids Res, 2023, 51(2):517-535
Oncol Rep, 2023, 49(5)94
S1218 Clofarabine Clofarabine (Clolar) inhibits the enzymatic activities of ribonucleotide reductase (RNR) (IC50 = 65 nM) and DNA polymerase. Clofarabine induces autophagy and apoptosis.
Front Oncol, 2023, 13:1287444
Cancer Res, 2022, 82(4):721-733
Clin Transl Med, 2022, 12(2):e747
S8246 RK-33 RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.
JCI Insight, 2023, 8(7)e167566
Mol Immunol, 2023, 154:54-60
MedComm (2020), 2022, 3(3):e133
S1840 Lomustine Lomustine (NSC79037, Gleostine, CeeNU, CCNU) inhibits cancer cells by damaging the DNA and stops cells from dividing.
Sci Rep, 2024, 14(1):4303
Cell Rep Med, 2023, S2666-3791(23)00156-8
Mol Biol Cell, 2023, 34(5):ar47
S1302 Ifosfamide Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.
Comput Struct Biotechnol J, 2023, 21:3827-3840
Nat Commun, 2022, 13(1):6308
Cells, 2022, 11(14)2164
S1807 Acyclovir (Aciclovir) Acyclovir (Aciclovir) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.
iScience, 2022, 25(12):105682
Pharmaceutics, 2022, 14(3)536
Eur J Pharm Biopharm, 2022, S0939-6411(22)00047-9
S1289 Carmofur Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer.
JCI Insight, 2023, 8(9)e166850
Cell Death Discov, 2023, 9(1):451
Int J Mol Sci, 2023, 24(7)6062
S7470 Triapine (3-AP) Triapine (3-AP) is a potent ribonucleotide reductase (RNR) inhibitor with broad spectrum antitumor activity by inhibiting DNA synthesis. Phase 2.
J Virol, 2023, 97(8):e0026723
Res Sq, 2023, rs.3.rs-3126261
Cancer Res, 2022, 82(4):721-733
S1192 Raltitrexed Raltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.
Mol Ther, 2022, S1525-0016(22)00717-1
ACS Chem Neurosci, 2022, 13(17):2646-2657
Biochem Biophys Res Commun, 2022, 610:1-7
S1221 Dacarbazine Dacarbazine is a triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis; used in the treatment of various cancers.
BMC Complement Med Ther, 2023, 23(1):111
NPJ Precis Oncol, 2022, 6(1:81)
J Pers Med, 2022, 12(2)258
S1305 Mercaptopurine (6-MP) Mercaptopurine(6-MP) is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
Nat Commun, 2023, 14(1):5913
Nat Commun, 2023, 14(1):5913
J Pers Med, 2022, 12(2)258
S8434 B02 B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM).
iScience, 2024, 27(2):108814
Cell Prolif, 2023, 56(4):e13384
Cancer Med, 2023, 12(6):6594-6602
S7718 BMH-21 BMH-21 is a DNA intercalator, which binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription.
Elife, 2024, 13e80684
Exp Ther Med, 2024, 27(3):107.
Exp Ther Med, 2024, 27(3):107
S1213 Nelarabine Nelarabine (506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.
Cancer Res, 2022, 82(4):721-733
Cell Rep, 2022, 39(10):110913
J Pers Med, 2022, 12(2)258
S7679 YK-4-279 YK-4-279 is a potent inhibitor of EWS-FLI1 binding to RNA helicase A (RHA).
Cancers -Basel), 2023, 15(19)4772
Cell Chem Biol, 2022, 29(8):1325-1332.e4
Front Oncol, 2021, 11:649323
S1764 Rifampin (Rifampicin) Rifampin (Rifampicin) is a DNA-dependent RNA polymerase inhibitor, used to treat a number of bacterial infections.
Cell Death Dis, 2023, 14(1):64
Int J Mol Sci, 2022, 23(13)7383
Biomedicines, 2021, 9(8)996
S1299 Floxuridine (FUDR) Floxuridine (FUDR) is a prodrug that is rapidly catabolized to 5-fluorouracil in vivo. Floxuridine is used to treat various cancers, particularly metastases to the liver. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage and apoptosis. Floxuridine has antiviral effects against HSV and CMV.
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Cell Chem Biol, 2021, S2451-9456(21)00306-8
S7918 BrdU (Bromodeoxyuridine) BrdU (Bromodeoxyuridine) is a nucleoside analog that competes with thymidine for incorporation into DNA, and used in the detection of proliferating cells.
Heliyon, 2024, 10(3):e24779
Anal Cell Pathol -Amst), 2023, 2023:1293200
Am J Cancer Res, 2021, 11(2):389-415
S1949 Menadione (Vitamin K3) Menadione (Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.
Med -N Y, 2022, S2666-6340-2200365-8
Mol Cell, 2021, S1097-2765(21)00269-0
DNA Repair (Amst), 2021, 105:103152
S1995 Procarbazine HCl Procarbazine HCl (NSC-77213) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound, used for the treatment of Hodgkin's lymphoma.
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Hum Cell, 2021, 34(6):1911-1918
S4239 Bergapten Bergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication.
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Hum Cell, 2021, 10.1007/s13577-021-00579-z
S4288 Chloroambucil Chloroambucil (Chlorambucil,CB-1348,WR-139013) is a nitrogen mustard alkylating agent, used in the treatment of chronic lymphocytic leukemia.
bioRxiv, 2023, 2023.01.17.524444
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
S1516 Cidofovir Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.
Oncol Lett, 2021, 21(4):280
Nat Biotechnol, 2019, 37(3):303-313
Antiviral Res, 2019, 162:178-185
S2678 NSC 207895 NSC 207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
PLoS One, 2024, 19(1):e0295629
Front Oncol, 2021, 11:582511
Genes Dev, 2020, 34(7-8):526-543
S1778 Trifluridine (NSC 75520) Trifluridine (NSC 529182, NSC 75520, Viroptic, Trifluorothymidine, TFT) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.
Nat Med, 2023, 29(3):605-614
JCI Insight, 2022, 7(22e158060)
Biochem Biophys Res Commun, 2022, 610:119-126
S1300 Tegafur (FT-207) Tegafur (NSC 148958,Fluorafur,FT-207) is a substance being used in the treatment of some types of cancer.
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Hum Cell, 2021, 34(6):1911-1918
S4194 Azaguanine-8 Azaguanine-8 (NSC-749, SF-337, SK 1150) is a purine analogs showing antineoplastic activity by competing with guanine in the metabolism.
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Hum Cell, 2021, 10.1007/s13577-021-00579-z
S8144 Halofuginone Halofuginone (RU-19110) is the competitively inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal.
Infect Agent Cancer, 2023, 18(1):27
FASEB J, 2022, 36(11):e22580
Invest Ophthalmol Vis Sci, 2022, 63(8):1
S1983 Adenine HCl Adenine HCl(6-Aminopurine hydrochloride) is a hydrochloride salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Hum Cell, 2021, 34(6):1911-1918
S4227 Fidaxomicin Fidaxomicin (OPT-80, PAR-101,Dificid) is a narrow spectrum macrocyclic antibiotic that inhibits RNA polymerase sigma subunit.
bioRxiv, 2023, 2023.03.13.532464
J Biol Chem, 2022, 298(4):101752
Gut Pathog, 2022, 14(1):4
S1384 Mizoribine Mizoribine is an imidazole nucleoside and an immunosuppressant that inhibits HCV RNA replication with IC50 of ~ 100 μM for anti-HCV activity. Mizoribine is a selective inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH) and guanosine monophosphate synthetase. Mizoribine also inhibits SARS-CoV.
EMBO J, 2023, e110620.
bioRxiv, 2022, 2021.07.02.450964
Cell Death Differ, 2021, 10.1038/s41418-021-00853-5
S4297 Mupirocin Mupirocin(BRL-4910A,Pseudomonic acid) is an isoleucyl t-RNA synthetase inhibitor, used in the treatment of bacterial skin infections.
Infect Drug Resist, 2023, 16:4867-4879
Infect Drug Resist, 2023, 16:4867-4879
Anaerobe, 2020, 62:102169
S1217 Cyclophosphamide Cyclophosphamide(NSC 26271,Endoxan, Cytoxan, Neosar, Procytox, Revimmune, Cytophosphane) is a nitrogen mustard alkylating agent from the oxazophorines group.
J Immunother, 2024, 10.1097/CJI.0000000000000505
Stem Cell Res Ther, 2023, 14(1):75
Antioxidants (Basel), 2023, 13(1)3
S1973 Cyclocytidine HCl Cyclocytidine (NSC 145668) is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia.
Transl Oncol, 2023, 35:101712
PeerJ, 2022, 10:e13719
Acta Biochim Biophys Sin (Shanghai), 2020, 14 pii: gmaa017
S4803 Thymidine Thymidine is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. As a constituent of DNA, thymidine pairs with adenine in the DNA double helix.
EMBO J, 2023, e110620.
Med Oncol, 2022, 39(10):140
Elife, 2021, 10e65234
S2029 Uridine Uridine (NSC 20256,β-Uridine, Uridin) is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond.
Cancer Res, 2022, canres.1707.2021
iScience, 2022, 25(5):104293
J Med Chem, 2021, 64(18):13918-13932
S5948 Amodiaquine Amodiaquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis. It is used for the therapy of malaria.
Nat Biomed Eng, 2021, 10.1038/s41551-021-00718-9
bioRxiv, 2020, 10.1101/2020.04.13.039917
bioRxiv, 2020, 2020/9/20.4.7.30734
S1907 Metronidazole Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa.
Microorganisms, 2022, 10(7)1421
Elife, 2021, 10e69795
Bone Joint Res, 2020, 16;9(4):152-161
S1760 Rifapentine Rifapentine (MDL473) is an antibiotic, which inhibits DNA-dependent RNA polymerase activity, used to treat tuberculosis.
Int J Mol Sci, 2022, 23(13)7383
Front Microbiol, 2020, 10:2936
mSphere, 2018, 3(5)
S1784 Vidarabine Vidarabine is an antiviral drug by interfering with the synthesis of viral DNA, used to treat herpes simplex and varicella zoster viruses.
Neuron, 2017, 96(6):1290-1302
ACS Appl Mater Interfaces, 2016, 8(39):25818-25824
Biogerontology, 2016, 17(5-6):907-920
S1826 Nedaplatin Nedaplatin(NSC 375101D) is a derivative of cisplatin and DNA damage agent for tumor colony forming units with IC50 of 94 μM.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
Nat Commun, 2019, 10(1):5654
Cancer Res, 2018, 78(19):5694-5705
Oncol Lett, 2016, 12(5):4195-4202
S7445 APX-3330 APX-3330 (E3330) is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.
J Transl Med, 2023, 21(1):183
Cell Death Dis, 2022, 13(2):124
Cancer Research on Prevention and Treatment, 2020, (7): 492-497
S1334 Flupirtine maleate Flupirtine maleate is the salt form of Flupirtine, which is a centrally acting non-opioid analgesia, is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.
Assay Drug Dev Technol, 2019, 17(7):310-321
Elife, 2015, 4
S7757 6-Thio-dG 6-thio-dG (β-TGdR) is a nucleoside analog and telomerase substrate.
Radiation Medicine and Protection, 2022, 64-71
Clin Sci (Lond), 2020, 10.1042/CS20190890
S9521 Pentostatin Pentostatin(CI-825,Deoxycoformycin) is a potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
Res Sq, 2023, rs.3.rs-2276903
Nat Metab, 2020, 10.1038/s42255-020-0227-4
S8539 TAS-102 TAS-102 (Trifluridine-Tipiracil Hydrochloride Mixture) is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride.
J Exp Clin Cancer Res, 2023, 42(1):8
Adv Sci (Weinh), 2021, e2103360
S3669 Carmustine Carmustine (bis-chloroethylnitrosourea, BCNU, BiCNU) is a cell-cycle phase nonspecific alkylating antineoplastic agent and used in the treatment of brain tumors and various other malignant neoplasms.
Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7
Cancer Res, 2021, 81(23):6044-6057
S8850 JH-RE-06 JH-RE-06 is a potent REV1-REV7 interface inhibitor with an IC50 of 0.78 μM and Kd value of 0.42 μM, disrupting REV1-POL ζ-mediated mutagenic translesion synthesis (TLS).
Mol Cell, 2022, S1097-2765(22)01070-X
Sci Adv, 2022, 8(19):eabn1229
S7546 Pritelivir (BAY 57-1293) Pritelivir (BAY 57-1293, AIC316) is a potent helicase primase inhibitor, exhibiting antiviral effect on herpes simplex virus (HSV) with IC50 of 20 nM for both HSV-1 and HSV-2.
PLoS Pathog, 2021, 17(11):e1010117
J Virol, 2021, JVI0166621
S9718 TK216

TK216 is a potent inhibitor targeting E26 transformation specific (ETS) factors via blocking the protein-protein interaction with RNA helicases. TK216 exhibits antilymphoma activity.

Sci Rep, 2023, 13(1):14360
Sci Rep, 2023, 13(1):14360
S1790 Rifaximin Rifaximin is a RNA synthesis inhibitor by binding the β subunit of the bacterial DNA-dependent RNA polymerase, used to treat traveler's diarrhea caused by certain bacteria.
Int J Mol Sci, 2022, 23(13)7383
S5552 Amenamevir Amenamevir (ASP2151) is a potent helicase-primase inhibitor and a novel class of antiviral agent.
J Biomol Struct Dyn, 2020, 1-14
S0280 Madrasin Madrasin (DDD00107587) is a potent and cell-penetrant pre-mRNA splicing inhibitor. Madrasin interferes with the early stages of spliceosome assembly and stalls spliceosome assembly at the A complex.
Leukemia, 2023, 37(8):1649-1659
S8095 Tubercidin Tubercidin (7-deaza-adenosine), an adenosine analogue, is a nucleoside antibiotic. It is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA and protein synthesis. This agent also exhibits antifungal and antiviral activities.
Mol Cell, 2020, 80(6):1104-1122.e9
S5484 Rimantadine Hydrochloride Rimantadine is an RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza. It works by inhibiting a viral protein called M2, which normally mediates the transport of acid ions across the influenza virion shell.
bioRxiv, 2020, 2020.08.12.246389
S3168 cis-Resveratrol cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA polymerases α and δ with IC50 of 2.7 μM, <1 μM, 1 μM, 3.3 μM and 5 μM, respectively.
J Gerontol A Biol Sci Med Sci, 2022, 77-8:1485-1493
S4737 Psoralen Psoralen (Psoralene, Ficusin, Furocoumarin) is a naturally occurring furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.
Metabolites, 2022, 13(1)3
E0488 BC-LI-0186 BC-LI-0186 is a selective blocker of Leucyl-tRNA synthetase (LRS; LeuRS) and Ras-related GTP-binding protein D (RagD) interaction (LRS-RagD interaction) (IC50 = 46.11 nM) by competing against RagD for LRS VC domain binding (KD = 42.1 nM), thereby inhibiting lysosomal localization of LRS and mTORC1 activity. It also effectively suppresses the activity of cancer-associated mTOR mutants and the growth of rapamycin-resistant cancer cells.
Cancer Res Treat, 2023, 55(3):851-864
S5953 Menadione bisulfite sodium Menadione(Vitamin K3) bisulfite sodium, a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.
Life Sci, 2020, 242:117159
S7449 CRT0044876 CRT0044876 (NSC 69877, 7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM.
Nat Biotechnol, 2017, 35(5):463-474
S3549 PFM01 PFM01, a cell-permeable N-alkylated Mirin derivative, is a selective inhibitor of MRE11 endonuclease activity.
Cell Rep, 2023, 42(7):112792
S7637 DTP3 DTP3 is a selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor and is able to restore MKK7/JNK activation. DTP3 inhibits cancer-selective NF-κB survival pathway.
MedComm (2020), 2023, 4(3):e269
S1981 Adenine Adenine(6-Aminopurine) is a purine derivative and a nucleobase with a variety of roles in biochemistry.
PLoS Pathog, 2020, 16;16(3):e1008341
S6854 Triazavirin Triazavirin (TZV, Riamilovir) is a novel antiviral drug, a nucleoside analogue of nucleic acid that inhibits the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is active against influenza and a number of other viruses. Triazavirin is an effective protective agent on the transmission stage of influenza.
Nature, 2022, 604(7904):120-126
S0469 ML216 ML216 (CID-49852229) is a potent and selective inhibitor of the DNA unwinding activity of BLM(Bloom’s syndrome protein) with antitumor activity. ML216 inhibits helicases with IC50 of 0.97 μM and 2.98 μM for BLM636-1298 and BLMfull-length, respectively.
Cells, 2022, 12(1)145
S3001 Clevudine Clevudine(Levovir,L-FMAU) is an antiviral drug for the treatment of hepatitis B.
E2939New Didox Didox (3,4-dihydroxy-benzohydroxamic acid) is a synthetic ribonucleotide reductase (RR) inhibitor derived from polyhydroxy-substituted benzohydroxamic acid. Didox inhibits proliferation of tamoxifen-resistant breast cancer cells.
S3009 Menthone

Menthone is one of the main volatile components of the essential oil of peppermint (Mentha piperita L.). Menthone is used as antioxidant agent and has a good compensatory effect with significant reduction in DNA damages in sperm cells.

S3472 Metarrestin Metarrestin is an orally active and specific perinucleolar compartment (PNC) inhibitor that disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription. Metarrestin blocks metastatic development and extends survival in mouse cancer models.
E1152 AGX51 AGX51, a first-in-class pan-Id (inhibitors of DNA-binding/differentiation proteins) antagonist and degrader, inhibits the Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids, cell growth arrest, and reduces viability, also inhibits pathologic ocular neovascularization.
S8376 Rbin-1 Rbin-1 (Ribozinoindole-1) is a potent chemical inhibitor of eukaryotic ribosome assembly. It inhibits recombinant full-length Mdn1's ATPase activity in vitro.
S6909 Levomefolic acid Levomefolic acid (5-MTHF, LMSR, Metafolin, Nutrifolin) is a natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions.
E0459 Robinetin Robinetin inhibits HIV integrase cleavage and integration in a dose-dependent manne, inhibits the DNA synthesis in Proteus vulgaris, and the RNA synthesis in S. aureus, also inhibits egg yolk phosphatidylcholine (EYPC) membrane lipid peroxidation and hemoglobin A (HbA) glycosylation with high efficiency.
E1596New AOH1996 AOH1996 is an orally active small-molecule PCNA inhibitor with potential anti-tumor activity. It enhances the interaction between PCNA and RPB1, the largest subunit of RNA polymerase II.
S0816 Brr2 Inhibitor C9 Brr2 inhibitor C9 (Brr2 Inhibitor 9) is an allosteric inhibitor of the spliceosomal RNA helicase Brr2. Brr2 is implicated in autosomal-dominant retinitis pigmentosa a group of progressive retinal degenerative disorders.
S4888 Guanine Guanine is one of the four main nucleobases found in the nucleic acids DNA and RNA.
S5813 Isoginkgetin Isoginkgetin is a naturally derived biflavonoid with anti-tumor activity. Isoginkgetin directly inhibits the chymotrypsin-like, trypsin-like, and caspase-like activities of the 20S proteasome. Isoginkgetin also is a general inhibitor of Pre-mRNA splicing.
S8328 CeMMEC1 HCl CeMMEC1 is an N-methylisoquinolinone derivative that inhibits the second bromodomain of TAF1 (IC50=0.9 μM).
S0054 D-I03 D-I03 is a selective inhibitor of RAD52 with Kd of 25.8 µM. D-I03 inhibits ssDNA annealing by RAD52 and D-loop formation with IC50 of 5 µM and 8 µM, respectively.
S0063 RG3039 RG3039 (PF-06687859, PF 6687859, Quinazoline 495) is an orally bioavailable and brain-penetrant inhibitor of the mRNA decapping enzyme DcpS with IC50 of 4.2 nM and IC90 of 40 nM, respectively.
S4504 6-Mercaptopurine (6-MP) Monohydrate 6-Mercaptopurine (6-MP) Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
S5505 2’-deoxyuridine 2'-deoxyuridine (dU, 2'-dU) is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms.
S0780 Oncrasin-1 Oncrasin-1 (Onc-1) is a potent RNA polymerase II inhibitor with antitumor activity that kills various human lung cancer cells with K-Ras mutations. Oncrasin-1 drives abnormal aggregation of protein kinase C iota (PKCι) in nucleus of sensitive cells but not in resistant cells.
S6359 Purine Purine is a heterocyclic aromatic organic compound which plays crucial roles in DNA and RNA. It is also significant components in a number of other important biomolecules, such as ATP, GTP, cyclic AMP, NADH, and coenzyme A.
S8942 Suramin sodium salt Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatase (PTPases) inhibitor, also is the potent inhibitor of sirtuins, purified topoisomerase II and SARS-CoV-2 RNA-dependent RNA polymerase (RdRp).
J Biol Chem, 2024, S0021-9258(24)00128-5
S9286 Neobavaisoflavone Neobavaisoflavone, isolated from seeds of Psoralea corylifolia, exhibits inhibitory activity against DNA polymerase and platelet aggregation.
S6848 3'-Fluoro-3'-deoxythymidine (Alovudine) 3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer.
E0443New LDC195943 (IMT1) LDC195943 (IMT1) is a specific and noncompetitive inhibitor of human mitochondrial RNA polymerase (POLRMT). IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases.
E0444New LDC203974 (IMT1B) LDC203974 (IMT1B) is an orally active, noncompetitive and specific allosteric inhibitor of mitochondrial RNA polymerase (POLRMT) and inhibits mitochondrial DNA (mtDNA) expression. LDC203974 has anti-tumour effects.
E1255 5-Ethynyluridine 5-Ethynyluridine (5-EU) is a cell-permeable nucleoside and can be used to label newly synthesized RNA.
S9649 Acelarin (NUC-1031) Acelarin (NUC-1031, Fosgemcitabine palabenamide, CPF-31, MTL-007, GTPL7389), a prodrug based on an aryloxy phosphoramidate derivative of gemcitabine, is a DNA synthesis inhibitor with EC50 of 0.2 nM.
E1331 SU056 SU056 is an inhibitor of Y box binding protein 1 (YB-1) with IC50 of 1.73 μM in Sk0V3 cells.
S0102 L 189 L 189 is a novel human DNA ligase inhibitor with IC50 of 5 μM, 9 μM and 5 μM for hLigI, hLigIII and hLigIV, respectively. L 189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L 189 specifically sensitizes cancer cells to DNA damage.
S9936 ART558 ART558 is a potent, selective, low molecular weight, allosteric inhibitor of DNA Polθ with an IC50 of 7.9 nM.
S3641 Osalmid Osalmid suppresses ribonucleotide reductase (RR) activity in a concentration-dependent manner, with a 50% RR activity-inhibitory concentration (IC50) of 8.23 μM.
S3360 Bis(2-ethylhexyl) phthalate

Bis(2-ethylhexyl) phthalate (Dioctyl phthalate, DOP, Diplast O, ESBO-D 82, Ergoplast FDO, Ergoplast FDO-S, Etalon) induces DNA strand breaks and gene expression alterations in larval zebrafish Danio rerio.

S5293 Nimustine Hydrochloride Nimustine Hydrochloride (Nidran) is the hydrochloride salt of nimustine, a nitrosourea with antineoplastic activity that alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death.
S5297 Vidarabine monohydrate Vidarabine (Spongoadenosine, Vira-A) is a nucleoside antibiotic with antiviral acitivity that interferes with the synthesis of viral DNA. It is used to treat herpes simplex and varicella zoster viruses.
S6997 CHAPS CHAPS is a zwitterionic surfactant that decreases the sequence specificity of the nucleosome.
E1111 VV116 VV116, a promising orally administered anti-SARS-CoV-2 nucleoside drug candidate, exerts functions by targeting the viral RNA-dependent RNA polymerase through its nucleoside triphosphate form with an IC50 of 0.67±0.24 μM.
S6115 Pyridoxal 5′-phosphate hydrate Pyridoxal 5′-phosphate (pyridoxal phosphate, Vitamin B6 phosphate, PAL-P, PLP), a vitamin B6 phosphate, is a coenzyme in a variety of enzymatic reactions.
E2921New Diethyl Pyrocarbonate Diethyl pyrocarbonate is a potent, non-specific inhibitor of RNase. It has been useful as an in vitro agent, relatively specific for binding to imidazole of histidine. It inhibits central chemosensitivity in rabbit and can modify Ser, Thr, His and Tyr residues.
S3356 Phosphonoacetic acid

Phosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. Phosphonoacetic acid exhibits anti-viral activities.

S8326 Saccharin 1-methylimidazole (SMI) Saccharin 1-methylimidazole (SMI) is considered a general-purpose activator for DNA and RNA synthesis.
S0161 ML367 ML367 is a potent, micromolar inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization. ML367 blocks DNA repair pathways and general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation.
S8977 BCH001 BCH001 is a specific PAPD5 inhibitor that restores telomerase activity and telomere length in dyskeratosis congenita (DC) patient induced pluripotent stem cells. PAPD5 is a noncanonical poly(A) polymerase with an unusual RNA-binding motif.
S5828 L-Abrine L-Abrine (N-Methyl-L-tryptophan), an extremely toxic toxalbumin found in the seeds of the rosary pea, is a ribosome inhibiting protein.
S1982 Adenine sulfate Adenine sulfate(Adenine hemisulfate) is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.
E0510 Cidofovir hydrate Cidofovir hydrate is a selective inhibitor of viral DNA synthesis through the selective inhibition of viral DNA polymerase.
E1529New ART812 ART812 is an orally active DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM.
S6077 Cytidine 5′-triphosphate (disodium salt) Cytidine 5'-triphosphate is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions. It is used in the synthesis of RNA by RNA polymerases.
S9603 Lurbinectedin Lurbinectedin, a DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity. Lurbinectedin inhibits RMG1 and RMG2 cell growth with IC50 of 1.25 nM and 1.16 nM, respectively.
S6893 PIN1 inhibitor API-1 PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor with IC50 of 72.3 nM. PIN1 inhibitor API-1 targets Pin1 peptidyl-prolyl isomerase domain and inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 up-regulates miRNA biogenesis by retaining active XPO5 conformation and suppresses HCC development.
S4476 PCNA-I1 PCNA-I1 is a selective inhibitor of proliferating cell nuclear antigen (PCNA, a potential anticancer target). PCNA-I1 selectively binds to PCNA trimers with Kd of ~0.2 to 0.4 μM. PCNA-I1 inhibits the growth of tumor cells of various tissue types with IC50 of ~0.2 μM. PCNA-I1 induces DNA damage and apoptosis in both LNCaP and PC-3 cells. PCNA-I1 also induces autophagy in PC-3 cells.
S4236 Proflavine Hemisulfate Proflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands.
S5374 5'-Cytidylic acid 5'-Cytidylic acid (Cytidine monophosphate, Cytidine 5'-phosphate) is a nucleotide that is used as a monomer in RNA.
S5384 UTP Trisodium Salt Uridine-5'-triphosphate (UTP) is a pyrimidine nucleoside triphosphate and a substrate for the synthesis of RNA during transcription.
S2600 Fexinidazole Fexinidazole (HOE-239, Fexinidazole Winthrop) is a 5-nitroimidazole derivative. Fexinidazole is a DNA synthesis inhibitor and the only, all-oral agent for Human African Trypanosomiasis(HAT or sleeping sickness).
S2961 GC7 Sulfate GC7 (N1-guanyl-1,7-diaminoheptane) Sulfate is an inhibitor of deoxyhypusine synthase (DHPS). GC7 inhibits Neuroblastoma (NB) cell proliferation in a dose-dependent manner, through induction of the cell cycle inhibitor p21 and reduction of total and phosphorylated Rb proteins.
S4782 5-methoxyflavone 5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity.
S4537 Oxolinic acid Oxolinic acid (Urinox, NSC 110364) is a quinolone antibiotic, inhibiting the enzyme DNA gyrase and DNA synthesis.It also acts as a dopamine reuptake inhibitor.
S4423 Emamectin Benzoate Emamectin Benzoate (EMB, MK-244) activates gamma-amino butyric acid (GABA) transporter. Emamectin Benzoate induces of reactive oxygen species (ROS)-mediated DNA damage and apoptosis.
E1070 Phen-DC3 Trifluoromethanesulfonate Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65 ± 6 and 50 ± 10 nM, respectively.
S8329 CeMMEC13 CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 µM).
E0511 Framycetin sulphate Framycetin sulfate (Neomycin B sulfate), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a Ki of 35 μM, and competes for specific divalent metal ion binding sites in RNase P RNA, also inhibits hammerhead ribozyme with a Ki of 13.5 μM.
S2427 Triglycidyl Isocyanurate (Teroxirone) Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry.
S9382 Thymine Thymine (5-methyluracil) is one of the four nucleobases in the nucleic acid of DNA.
S1166 Cisplatin シスプラチン (Cisplatin (NSC 119875, Cisplatinum, cis-diamminedichloroplatinum II, CDDP, cis DDP, DDP)) は無機白金錯体であり、腫瘍細胞中において DNA 付加物を形成することにより DNA 合成を阻害する能力を有します。シスプラチンはフェロトーシス (ferroptosis) を活性化し、オートファジー (autophagy) を誘導します。溶液は都度調製してください。DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.Solutions are unstable and should be fresh-prepared.
Nat Commun, 2024, 15(1):866
Clin Cancer Res, 2024, 30(1):187-197
Cancer Lett, 2024, 586:216695
S7418 Cycloheximide Cycloheximide, an antifungal antibiotic, is an eukaryote protein synthesis inhibitor with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively. Cycloheximide suppresses ferroptosis and inhibits autophagy.Solutions are unstable and should be fresh-prepared.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
Bioact Mater, 2024, 32:277-291
Nat Commun, 2024, 15(1):1282
Exp Mol Med, 2024, 56(1):177-191
S1714 Gemcitabine Gemcitabine, a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy. Gemcitabine induces a potent p53-dependent apoptosis.
Nat Commun, 2024, 15(1):1287
Genes Dis, 2024, 11(1):430-448
iScience, 2024, 27(1):108667
S1209 5-FU (5-Fluorouracil) 5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.
NPJ Precis Oncol, 2024, 8(1):52
Am J Cancer Res, 2024, 14(1):378-389
Frontiers, 2024, 10.3389/978-2-8325-4184-5
S1224 Oxaliplatin Oxaliplatin is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells.Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
Mol Cancer, 2024, 23(1):23
Gastroenterology, 2024, S0016-5085(24)00062-3
NPJ Precis Oncol, 2024, 8(1):52
S1491 Fludarabine Fludarabine is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis.
Nat Commun, 2024, 15(1):1718
Cell Rep Med, 2024, 5(2):101420
Mol Ther Nucleic Acids, 2024, 35(1):102125
S1149 Gemcitabine HCl ゲムシタビン塩酸塩 (Gemcitabine (LY-188011, NSC 613327) HCl) は DNA 合成阻害剤であり、 PANC1 細胞、 MIAPaCa2 細胞、 BxPC3 細胞および Capan2 細胞における IC50 はそれぞれ 50 nM, 40 nM, 18nM, 12 nM です。
Int J Biol Sci, 2024, 20(4):1389-1409
Phytomedicine, 2024, 155377
Neoplasia, 2024, 47:100951
S1215 Carboplatin Carboplatin is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells.Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
Clin Cancer Res, 2024, 30(1):187-197
Int J Mol Sci, 2024, 25(2)886
Nat Commun, 2023, 14(1):4057
S8146 Mitomycin C Mitomycin C (Ametycine) is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
Clin Transl Med, 2024, 14(2):e1586
Stem Cell Res Ther, 2024, 15(1):26
Burns Trauma, 2024, 12:tkad058
S1117 Triciribine (API-2) Triciribine (API-2) is a DNA synthesis inhibitor, also inhibits Akt in PC3 cell line and HIV-1 in CEM-SS, H9, H9IIIB, U1 cells with IC50 of 130 nM and 20 nM, respectively; does not inhibit PI3K/PDK1; 5000-fold less active in cells lacking adenosine kinase. Phase 1/2.
J Cell Sci, 2023, 136(4)jcs259788
Exp Gerontol, 2023, 173:112091
EJHaem, 2023, 4(3):631-638
S8932 Remdesivir (GS-5734) Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV.
Int J Mol Sci, 2024, 24;25(3):1427.
Nature, 2023, 613(7944):558-564
Cell, 2023, 186(4):850-863.e16
S1648 Cytarabine Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis.
iScience, 2024, 27(1):108667
Int J Mol Sci, 2024, 25(1)646
Cell Signal, 2024, 114:111004
S8964 Actinomycin D (Dactinomycin) Actinomycin D (Dactinomycin, Act D, RASP-101) is a significant polypeptide antibiotic isolated from soil bacteria of the genus Streptomyces. Actinomycin D (Dactinomycin) inhibits DNA repair and rests the cell cycle at G1 phase with IC50 of 0.42 μM and 0.4 nM, respectively. Actinomycin D is an autophagy activator, induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
Cell Mol Life Sci, 2024, 81(1):92
NPJ Precis Oncol, 2024, 8(1):22
Signal Transduct Target Ther, 2023, 8(1):63
S3035 Daunorubicin HCl Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis.
Cell Stem Cell, 2023, 10.1016/j.stem.2023.09.011
Int J Mol Sci, 2023, 24(16)12926
Cancers (Basel), 2023, 15(12)3112
S2684 Pidnarulex (CX-5461) Pidnarulex (CX-5461) is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.
Sci Rep, 2024, 14(1):4060
PLoS One, 2024, 19(1):e0295629
Exp Ther Med, 2024, 27(3):107.
S1229 Fludarabine Phosphate Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.
J Biomed Sci, 2022, 29(1):20
J Neuroinflammation, 2022, 19(1):109
Int J Biol Sci, 2022, 18(1):331-348
S1135 Pemetrexed disodium Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
Cancer Cell, 2022, 40(10):1128-1144.e8
Cell Rep, 2022, 38(9):110448
Front Pharmacol, 2022, 13:1032975
S1896 Hydroxyurea Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. Hydroxyurea activates apoptosis and autophagy. Hydroxyurea is used to treat HIV infection.
bioRxiv, 2024, 10.1101/2024.01.04.574133
Cell Rep, 2023, 42(7):112660
Cell Rep, 2023, 42(10):113176
S2794 Sofosbuvir Sofosbuvir is a HCV NS5B polymerase inhibitor for the treatment of chronic hepatitis C virus (HCV) infection.
mBio, 2023, 10.1128/mbio.01318-23
Commun Biol, 2023, 6(1):511
Nat Commun, 2022, 13(1):2079
S7742 SCR7 SCR7 is a specific DNA Ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ).
iScience, 2024, 27(2):108814
Nat Commun, 2023, 14(1):4761
Mol Ther Nucleic Acids, 2023, 31:309-323
S2239 Tubacin Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1. Tubacin reduces the replication of the Japanese Encephalitis Virus via the decrease of viral RNA synthesis.
Br J Cancer, 2023, 10.1038/s41416-023-02195-0
Int J Mol Sci, 2023, 24(5)4720
Oncogene, 2022, 10.1038/s41388-022-02236-7
S1156 Capecitabine Capecitabine is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis.
Genes Dis, 2024, 11(1):430-448
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
S5971 Pemetrexed Pemetrexed (LY231514) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
Mol Cancer Res, 2024, 22(1):82-93
Amino Acids, 2024, 56(1):15
Cell Death Dis, 2023, 10.1038/s41419-023-06240-x
S1373 Daptomycin Daptomycin is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms.
Molecules, 2023, 28(2)621
Infect Drug Resist, 2023, 16:4867-4879
Infect Drug Resist, 2023, 16:4867-4879
S1199 Cladribine Cladribine is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.
Exp Hematol Oncol, 2023, 12(1):23
Neurol Neuroimmunol Neuroinflamm, 2023, 10(5)e200149
Am J Cancer Res, 2023, 13(2):355-378
S7419 Blasticidin S HCl Blasticidin S HCl is a nucleoside antibiotic isolated from Stretomyces girseochromogenes. It acts by blocking hydrolysis of peptidyl-tRNA induced by release factors and inhibits peptide bond formation. It is used to select transfected cells carrying bsr or BSD resistance genes.
Nat Commun, 2023, 10.1038/s41467-023-42850-x
Nat Commun, 2023, 14(1):2978
Nat Commun, 2023, 14(1):6473
S5582 Cytarabine hydrochloride Cytarabine is a pyrimidine nucleoside analog that is used mainly in the treatment of leukemia. It is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA.
Blood, 2022, blood.2022016090
Clin Transl Med, 2022, 12(2):e722
Front Pharmacol, 2022, 13:1032975
S7975 Favipiravir (T-705) Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.
J Med Virol, 2024, 96(1):e29372
Nat Commun, 2022, 13(1):2256
Nucleic Acids Res, 2022, gkac512
S1218 Clofarabine Clofarabine (Clolar) inhibits the enzymatic activities of ribonucleotide reductase (RNR) (IC50 = 65 nM) and DNA polymerase. Clofarabine induces autophagy and apoptosis.
Front Oncol, 2023, 13:1287444
Cancer Res, 2022, 82(4):721-733
Clin Transl Med, 2022, 12(2):e747
S8246 RK-33 RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.
JCI Insight, 2023, 8(7)e167566
Mol Immunol, 2023, 154:54-60
MedComm (2020), 2022, 3(3):e133
S1302 Ifosfamide Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.
Comput Struct Biotechnol J, 2023, 21:3827-3840
Nat Commun, 2022, 13(1):6308
Cells, 2022, 11(14)2164
S1807 Acyclovir (Aciclovir) Acyclovir (Aciclovir) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.
iScience, 2022, 25(12):105682
Pharmaceutics, 2022, 14(3)536
Eur J Pharm Biopharm, 2022, S0939-6411(22)00047-9
S1289 Carmofur Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer.
JCI Insight, 2023, 8(9)e166850
Cell Death Discov, 2023, 9(1):451
Int J Mol Sci, 2023, 24(7)6062
S7470 Triapine (3-AP) Triapine (3-AP) is a potent ribonucleotide reductase (RNR) inhibitor with broad spectrum antitumor activity by inhibiting DNA synthesis. Phase 2.
J Virol, 2023, 97(8):e0026723
Res Sq, 2023, rs.3.rs-3126261
Cancer Res, 2022, 82(4):721-733
S1192 Raltitrexed Raltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.
Mol Ther, 2022, S1525-0016(22)00717-1
ACS Chem Neurosci, 2022, 13(17):2646-2657
Biochem Biophys Res Commun, 2022, 610:1-7
S1221 Dacarbazine Dacarbazine is a triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis; used in the treatment of various cancers.
BMC Complement Med Ther, 2023, 23(1):111
NPJ Precis Oncol, 2022, 6(1:81)
J Pers Med, 2022, 12(2)258
S1305 Mercaptopurine (6-MP) Mercaptopurine(6-MP) is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
Nat Commun, 2023, 14(1):5913
Nat Commun, 2023, 14(1):5913
J Pers Med, 2022, 12(2)258
S8434 B02 B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM).
iScience, 2024, 27(2):108814
Cell Prolif, 2023, 56(4):e13384
Cancer Med, 2023, 12(6):6594-6602
S7718 BMH-21 BMH-21 is a DNA intercalator, which binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription.
Elife, 2024, 13e80684
Exp Ther Med, 2024, 27(3):107.
Exp Ther Med, 2024, 27(3):107
S1213 Nelarabine Nelarabine (506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.
Cancer Res, 2022, 82(4):721-733
Cell Rep, 2022, 39(10):110913
J Pers Med, 2022, 12(2)258
S7679 YK-4-279 YK-4-279 is a potent inhibitor of EWS-FLI1 binding to RNA helicase A (RHA).
Cancers -Basel), 2023, 15(19)4772
Cell Chem Biol, 2022, 29(8):1325-1332.e4
Front Oncol, 2021, 11:649323
S1764 Rifampin (Rifampicin) Rifampin (Rifampicin) is a DNA-dependent RNA polymerase inhibitor, used to treat a number of bacterial infections.
Cell Death Dis, 2023, 14(1):64
Int J Mol Sci, 2022, 23(13)7383
Biomedicines, 2021, 9(8)996
S1299 Floxuridine (FUDR) Floxuridine (FUDR) is a prodrug that is rapidly catabolized to 5-fluorouracil in vivo. Floxuridine is used to treat various cancers, particularly metastases to the liver. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage and apoptosis. Floxuridine has antiviral effects against HSV and CMV.
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Cell Chem Biol, 2021, S2451-9456(21)00306-8
S1949 Menadione (Vitamin K3) Menadione (Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.
Med -N Y, 2022, S2666-6340-2200365-8
Mol Cell, 2021, S1097-2765(21)00269-0
DNA Repair (Amst), 2021, 105:103152
S1995 Procarbazine HCl Procarbazine HCl (NSC-77213) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound, used for the treatment of Hodgkin's lymphoma.
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Hum Cell, 2021, 34(6):1911-1918
S4239 Bergapten Bergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication.
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Hum Cell, 2021, 10.1007/s13577-021-00579-z
S4288 Chloroambucil Chloroambucil (Chlorambucil,CB-1348,WR-139013) is a nitrogen mustard alkylating agent, used in the treatment of chronic lymphocytic leukemia.
bioRxiv, 2023, 2023.01.17.524444
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
S1516 Cidofovir Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.
Oncol Lett, 2021, 21(4):280
Nat Biotechnol, 2019, 37(3):303-313
Antiviral Res, 2019, 162:178-185
S2678 NSC 207895 NSC 207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
PLoS One, 2024, 19(1):e0295629
Front Oncol, 2021, 11:582511
Genes Dev, 2020, 34(7-8):526-543
S1778 Trifluridine (NSC 75520) Trifluridine (NSC 529182, NSC 75520, Viroptic, Trifluorothymidine, TFT) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.
Nat Med, 2023, 29(3):605-614
JCI Insight, 2022, 7(22e158060)
Biochem Biophys Res Commun, 2022, 610:119-126
S1300 Tegafur (FT-207) Tegafur (NSC 148958,Fluorafur,FT-207) is a substance being used in the treatment of some types of cancer.
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Hum Cell, 2021, 34(6):1911-1918
S8144 Halofuginone Halofuginone (RU-19110) is the competitively inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal.
Infect Agent Cancer, 2023, 18(1):27
FASEB J, 2022, 36(11):e22580
Invest Ophthalmol Vis Sci, 2022, 63(8):1
S4227 Fidaxomicin Fidaxomicin (OPT-80, PAR-101,Dificid) is a narrow spectrum macrocyclic antibiotic that inhibits RNA polymerase sigma subunit.
bioRxiv, 2023, 2023.03.13.532464
J Biol Chem, 2022, 298(4):101752
Gut Pathog, 2022, 14(1):4
S1384 Mizoribine Mizoribine is an imidazole nucleoside and an immunosuppressant that inhibits HCV RNA replication with IC50 of ~ 100 μM for anti-HCV activity. Mizoribine is a selective inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH) and guanosine monophosphate synthetase. Mizoribine also inhibits SARS-CoV.
EMBO J, 2023, e110620.
bioRxiv, 2022, 2021.07.02.450964
Cell Death Differ, 2021, 10.1038/s41418-021-00853-5
S4297 Mupirocin Mupirocin(BRL-4910A,Pseudomonic acid) is an isoleucyl t-RNA synthetase inhibitor, used in the treatment of bacterial skin infections.
Infect Drug Resist, 2023, 16:4867-4879
Infect Drug Resist, 2023, 16:4867-4879
Anaerobe, 2020, 62:102169
S1217 Cyclophosphamide Cyclophosphamide(NSC 26271,Endoxan, Cytoxan, Neosar, Procytox, Revimmune, Cytophosphane) is a nitrogen mustard alkylating agent from the oxazophorines group.
J Immunother, 2024, 10.1097/CJI.0000000000000505
Stem Cell Res Ther, 2023, 14(1):75
Antioxidants (Basel), 2023, 13(1)3
S1973 Cyclocytidine HCl Cyclocytidine (NSC 145668) is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia.
Transl Oncol, 2023, 35:101712
PeerJ, 2022, 10:e13719
Acta Biochim Biophys Sin (Shanghai), 2020, 14 pii: gmaa017
S5948 Amodiaquine Amodiaquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis. It is used for the therapy of malaria.
Nat Biomed Eng, 2021, 10.1038/s41551-021-00718-9
bioRxiv, 2020, 10.1101/2020.04.13.039917
bioRxiv, 2020, 2020/9/20.4.7.30734
S1907 Metronidazole Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa.
Microorganisms, 2022, 10(7)1421
Elife, 2021, 10e69795
Bone Joint Res, 2020, 16;9(4):152-161
S1760 Rifapentine Rifapentine (MDL473) is an antibiotic, which inhibits DNA-dependent RNA polymerase activity, used to treat tuberculosis.
Int J Mol Sci, 2022, 23(13)7383
Front Microbiol, 2020, 10:2936
mSphere, 2018, 3(5)
S1784 Vidarabine Vidarabine is an antiviral drug by interfering with the synthesis of viral DNA, used to treat herpes simplex and varicella zoster viruses.
Neuron, 2017, 96(6):1290-1302
ACS Appl Mater Interfaces, 2016, 8(39):25818-25824
Biogerontology, 2016, 17(5-6):907-920
S1826 Nedaplatin Nedaplatin(NSC 375101D) is a derivative of cisplatin and DNA damage agent for tumor colony forming units with IC50 of 94 μM.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
Nat Commun, 2019, 10(1):5654
Cancer Res, 2018, 78(19):5694-5705
Oncol Lett, 2016, 12(5):4195-4202
S7445 APX-3330 APX-3330 (E3330) is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.
J Transl Med, 2023, 21(1):183
Cell Death Dis, 2022, 13(2):124
Cancer Research on Prevention and Treatment, 2020, (7): 492-497
S7757 6-Thio-dG 6-thio-dG (β-TGdR) is a nucleoside analog and telomerase substrate.
Radiation Medicine and Protection, 2022, 64-71
Clin Sci (Lond), 2020, 10.1042/CS20190890
S9521 Pentostatin Pentostatin(CI-825,Deoxycoformycin) is a potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
Res Sq, 2023, rs.3.rs-2276903
Nat Metab, 2020, 10.1038/s42255-020-0227-4
S8539 TAS-102 TAS-102 (Trifluridine-Tipiracil Hydrochloride Mixture) is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride.
J Exp Clin Cancer Res, 2023, 42(1):8
Adv Sci (Weinh), 2021, e2103360
S3669 Carmustine Carmustine (bis-chloroethylnitrosourea, BCNU, BiCNU) is a cell-cycle phase nonspecific alkylating antineoplastic agent and used in the treatment of brain tumors and various other malignant neoplasms.
Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7
Cancer Res, 2021, 81(23):6044-6057
S8850 JH-RE-06 JH-RE-06 is a potent REV1-REV7 interface inhibitor with an IC50 of 0.78 μM and Kd value of 0.42 μM, disrupting REV1-POL ζ-mediated mutagenic translesion synthesis (TLS).
Mol Cell, 2022, S1097-2765(22)01070-X
Sci Adv, 2022, 8(19):eabn1229
S7546 Pritelivir (BAY 57-1293) Pritelivir (BAY 57-1293, AIC316) is a potent helicase primase inhibitor, exhibiting antiviral effect on herpes simplex virus (HSV) with IC50 of 20 nM for both HSV-1 and HSV-2.
PLoS Pathog, 2021, 17(11):e1010117
J Virol, 2021, JVI0166621
S9718 TK216

TK216 is a potent inhibitor targeting E26 transformation specific (ETS) factors via blocking the protein-protein interaction with RNA helicases. TK216 exhibits antilymphoma activity.

Sci Rep, 2023, 13(1):14360
Sci Rep, 2023, 13(1):14360
S1790 Rifaximin Rifaximin is a RNA synthesis inhibitor by binding the β subunit of the bacterial DNA-dependent RNA polymerase, used to treat traveler's diarrhea caused by certain bacteria.
Int J Mol Sci, 2022, 23(13)7383
S5552 Amenamevir Amenamevir (ASP2151) is a potent helicase-primase inhibitor and a novel class of antiviral agent.
J Biomol Struct Dyn, 2020, 1-14
S0280 Madrasin Madrasin (DDD00107587) is a potent and cell-penetrant pre-mRNA splicing inhibitor. Madrasin interferes with the early stages of spliceosome assembly and stalls spliceosome assembly at the A complex.
Leukemia, 2023, 37(8):1649-1659
S8095 Tubercidin Tubercidin (7-deaza-adenosine), an adenosine analogue, is a nucleoside antibiotic. It is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA and protein synthesis. This agent also exhibits antifungal and antiviral activities.
Mol Cell, 2020, 80(6):1104-1122.e9
S5484 Rimantadine Hydrochloride Rimantadine is an RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza. It works by inhibiting a viral protein called M2, which normally mediates the transport of acid ions across the influenza virion shell.
bioRxiv, 2020, 2020.08.12.246389
S3168 cis-Resveratrol cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA polymerases α and δ with IC50 of 2.7 μM, <1 μM, 1 μM, 3.3 μM and 5 μM, respectively.
J Gerontol A Biol Sci Med Sci, 2022, 77-8:1485-1493
S4737 Psoralen Psoralen (Psoralene, Ficusin, Furocoumarin) is a naturally occurring furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.
Metabolites, 2022, 13(1)3
E0488 BC-LI-0186 BC-LI-0186 is a selective blocker of Leucyl-tRNA synthetase (LRS; LeuRS) and Ras-related GTP-binding protein D (RagD) interaction (LRS-RagD interaction) (IC50 = 46.11 nM) by competing against RagD for LRS VC domain binding (KD = 42.1 nM), thereby inhibiting lysosomal localization of LRS and mTORC1 activity. It also effectively suppresses the activity of cancer-associated mTOR mutants and the growth of rapamycin-resistant cancer cells.
Cancer Res Treat, 2023, 55(3):851-864
S5953 Menadione bisulfite sodium Menadione(Vitamin K3) bisulfite sodium, a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.
Life Sci, 2020, 242:117159
S7449 CRT0044876 CRT0044876 (NSC 69877, 7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM.
Nat Biotechnol, 2017, 35(5):463-474
S3549 PFM01 PFM01, a cell-permeable N-alkylated Mirin derivative, is a selective inhibitor of MRE11 endonuclease activity.
Cell Rep, 2023, 42(7):112792
S7637 DTP3 DTP3 is a selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor and is able to restore MKK7/JNK activation. DTP3 inhibits cancer-selective NF-κB survival pathway.
MedComm (2020), 2023, 4(3):e269
S6854 Triazavirin Triazavirin (TZV, Riamilovir) is a novel antiviral drug, a nucleoside analogue of nucleic acid that inhibits the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is active against influenza and a number of other viruses. Triazavirin is an effective protective agent on the transmission stage of influenza.
Nature, 2022, 604(7904):120-126
S0469 ML216 ML216 (CID-49852229) is a potent and selective inhibitor of the DNA unwinding activity of BLM(Bloom’s syndrome protein) with antitumor activity. ML216 inhibits helicases with IC50 of 0.97 μM and 2.98 μM for BLM636-1298 and BLMfull-length, respectively.
Cells, 2022, 12(1)145
S3001 Clevudine Clevudine(Levovir,L-FMAU) is an antiviral drug for the treatment of hepatitis B.
E2939New Didox Didox (3,4-dihydroxy-benzohydroxamic acid) is a synthetic ribonucleotide reductase (RR) inhibitor derived from polyhydroxy-substituted benzohydroxamic acid. Didox inhibits proliferation of tamoxifen-resistant breast cancer cells.
S3009 Menthone

Menthone is one of the main volatile components of the essential oil of peppermint (Mentha piperita L.). Menthone is used as antioxidant agent and has a good compensatory effect with significant reduction in DNA damages in sperm cells.

S3472 Metarrestin Metarrestin is an orally active and specific perinucleolar compartment (PNC) inhibitor that disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription. Metarrestin blocks metastatic development and extends survival in mouse cancer models.
E1152 AGX51 AGX51, a first-in-class pan-Id (inhibitors of DNA-binding/differentiation proteins) antagonist and degrader, inhibits the Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids, cell growth arrest, and reduces viability, also inhibits pathologic ocular neovascularization.
S8376 Rbin-1 Rbin-1 (Ribozinoindole-1) is a potent chemical inhibitor of eukaryotic ribosome assembly. It inhibits recombinant full-length Mdn1's ATPase activity in vitro.
E0459 Robinetin Robinetin inhibits HIV integrase cleavage and integration in a dose-dependent manne, inhibits the DNA synthesis in Proteus vulgaris, and the RNA synthesis in S. aureus, also inhibits egg yolk phosphatidylcholine (EYPC) membrane lipid peroxidation and hemoglobin A (HbA) glycosylation with high efficiency.
E1596New AOH1996 AOH1996 is an orally active small-molecule PCNA inhibitor with potential anti-tumor activity. It enhances the interaction between PCNA and RPB1, the largest subunit of RNA polymerase II.
S0816 Brr2 Inhibitor C9 Brr2 inhibitor C9 (Brr2 Inhibitor 9) is an allosteric inhibitor of the spliceosomal RNA helicase Brr2. Brr2 is implicated in autosomal-dominant retinitis pigmentosa a group of progressive retinal degenerative disorders.
S5813 Isoginkgetin Isoginkgetin is a naturally derived biflavonoid with anti-tumor activity. Isoginkgetin directly inhibits the chymotrypsin-like, trypsin-like, and caspase-like activities of the 20S proteasome. Isoginkgetin also is a general inhibitor of Pre-mRNA splicing.
S8328 CeMMEC1 HCl CeMMEC1 is an N-methylisoquinolinone derivative that inhibits the second bromodomain of TAF1 (IC50=0.9 μM).
S0054 D-I03 D-I03 is a selective inhibitor of RAD52 with Kd of 25.8 µM. D-I03 inhibits ssDNA annealing by RAD52 and D-loop formation with IC50 of 5 µM and 8 µM, respectively.
S0063 RG3039 RG3039 (PF-06687859, PF 6687859, Quinazoline 495) is an orally bioavailable and brain-penetrant inhibitor of the mRNA decapping enzyme DcpS with IC50 of 4.2 nM and IC90 of 40 nM, respectively.
S4504 6-Mercaptopurine (6-MP) Monohydrate 6-Mercaptopurine (6-MP) Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
S0780 Oncrasin-1 Oncrasin-1 (Onc-1) is a potent RNA polymerase II inhibitor with antitumor activity that kills various human lung cancer cells with K-Ras mutations. Oncrasin-1 drives abnormal aggregation of protein kinase C iota (PKCι) in nucleus of sensitive cells but not in resistant cells.
S8942 Suramin sodium salt Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatase (PTPases) inhibitor, also is the potent inhibitor of sirtuins, purified topoisomerase II and SARS-CoV-2 RNA-dependent RNA polymerase (RdRp).
J Biol Chem, 2024, S0021-9258(24)00128-5
S9286 Neobavaisoflavone Neobavaisoflavone, isolated from seeds of Psoralea corylifolia, exhibits inhibitory activity against DNA polymerase and platelet aggregation.
S6848 3'-Fluoro-3'-deoxythymidine (Alovudine) 3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer.
E0443New LDC195943 (IMT1) LDC195943 (IMT1) is a specific and noncompetitive inhibitor of human mitochondrial RNA polymerase (POLRMT). IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases.
E0444New LDC203974 (IMT1B) LDC203974 (IMT1B) is an orally active, noncompetitive and specific allosteric inhibitor of mitochondrial RNA polymerase (POLRMT) and inhibits mitochondrial DNA (mtDNA) expression. LDC203974 has anti-tumour effects.
S9649 Acelarin (NUC-1031) Acelarin (NUC-1031, Fosgemcitabine palabenamide, CPF-31, MTL-007, GTPL7389), a prodrug based on an aryloxy phosphoramidate derivative of gemcitabine, is a DNA synthesis inhibitor with EC50 of 0.2 nM.
E1331 SU056 SU056 is an inhibitor of Y box binding protein 1 (YB-1) with IC50 of 1.73 μM in Sk0V3 cells.
S0102 L 189 L 189 is a novel human DNA ligase inhibitor with IC50 of 5 μM, 9 μM and 5 μM for hLigI, hLigIII and hLigIV, respectively. L 189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L 189 specifically sensitizes cancer cells to DNA damage.
S9936 ART558 ART558 is a potent, selective, low molecular weight, allosteric inhibitor of DNA Polθ with an IC50 of 7.9 nM.
S3641 Osalmid Osalmid suppresses ribonucleotide reductase (RR) activity in a concentration-dependent manner, with a 50% RR activity-inhibitory concentration (IC50) of 8.23 μM.
S3360 Bis(2-ethylhexyl) phthalate

Bis(2-ethylhexyl) phthalate (Dioctyl phthalate, DOP, Diplast O, ESBO-D 82, Ergoplast FDO, Ergoplast FDO-S, Etalon) induces DNA strand breaks and gene expression alterations in larval zebrafish Danio rerio.

S5293 Nimustine Hydrochloride Nimustine Hydrochloride (Nidran) is the hydrochloride salt of nimustine, a nitrosourea with antineoplastic activity that alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death.
S5297 Vidarabine monohydrate Vidarabine (Spongoadenosine, Vira-A) is a nucleoside antibiotic with antiviral acitivity that interferes with the synthesis of viral DNA. It is used to treat herpes simplex and varicella zoster viruses.
E1111 VV116 VV116, a promising orally administered anti-SARS-CoV-2 nucleoside drug candidate, exerts functions by targeting the viral RNA-dependent RNA polymerase through its nucleoside triphosphate form with an IC50 of 0.67±0.24 μM.
S6115 Pyridoxal 5′-phosphate hydrate Pyridoxal 5′-phosphate (pyridoxal phosphate, Vitamin B6 phosphate, PAL-P, PLP), a vitamin B6 phosphate, is a coenzyme in a variety of enzymatic reactions.
E2921New Diethyl Pyrocarbonate Diethyl pyrocarbonate is a potent, non-specific inhibitor of RNase. It has been useful as an in vitro agent, relatively specific for binding to imidazole of histidine. It inhibits central chemosensitivity in rabbit and can modify Ser, Thr, His and Tyr residues.
S3356 Phosphonoacetic acid

Phosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. Phosphonoacetic acid exhibits anti-viral activities.

S0161 ML367 ML367 is a potent, micromolar inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization. ML367 blocks DNA repair pathways and general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation.
S8977 BCH001 BCH001 is a specific PAPD5 inhibitor that restores telomerase activity and telomere length in dyskeratosis congenita (DC) patient induced pluripotent stem cells. PAPD5 is a noncanonical poly(A) polymerase with an unusual RNA-binding motif.
E0510 Cidofovir hydrate Cidofovir hydrate is a selective inhibitor of viral DNA synthesis through the selective inhibition of viral DNA polymerase.
E1529New ART812 ART812 is an orally active DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM.
S4236 Proflavine Hemisulfate Proflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands.
S2600 Fexinidazole Fexinidazole (HOE-239, Fexinidazole Winthrop) is a 5-nitroimidazole derivative. Fexinidazole is a DNA synthesis inhibitor and the only, all-oral agent for Human African Trypanosomiasis(HAT or sleeping sickness).
S2961 GC7 Sulfate GC7 (N1-guanyl-1,7-diaminoheptane) Sulfate is an inhibitor of deoxyhypusine synthase (DHPS). GC7 inhibits Neuroblastoma (NB) cell proliferation in a dose-dependent manner, through induction of the cell cycle inhibitor p21 and reduction of total and phosphorylated Rb proteins.
S4782 5-methoxyflavone 5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity.
S4537 Oxolinic acid Oxolinic acid (Urinox, NSC 110364) is a quinolone antibiotic, inhibiting the enzyme DNA gyrase and DNA synthesis.It also acts as a dopamine reuptake inhibitor.
E1070 Phen-DC3 Trifluoromethanesulfonate Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65 ± 6 and 50 ± 10 nM, respectively.
S8329 CeMMEC13 CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 µM).
E0511 Framycetin sulphate Framycetin sulfate (Neomycin B sulfate), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a Ki of 35 μM, and competes for specific divalent metal ion binding sites in RNase P RNA, also inhibits hammerhead ribozyme with a Ki of 13.5 μM.
S2427 Triglycidyl Isocyanurate (Teroxirone) Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry.
S8326 Saccharin 1-methylimidazole (SMI) Saccharin 1-methylimidazole (SMI) is considered a general-purpose activator for DNA and RNA synthesis.
S6893 PIN1 inhibitor API-1 PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor with IC50 of 72.3 nM. PIN1 inhibitor API-1 targets Pin1 peptidyl-prolyl isomerase domain and inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 up-regulates miRNA biogenesis by retaining active XPO5 conformation and suppresses HCC development.
S4476 PCNA-I1 PCNA-I1 is a selective inhibitor of proliferating cell nuclear antigen (PCNA, a potential anticancer target). PCNA-I1 selectively binds to PCNA trimers with Kd of ~0.2 to 0.4 μM. PCNA-I1 inhibits the growth of tumor cells of various tissue types with IC50 of ~0.2 μM. PCNA-I1 induces DNA damage and apoptosis in both LNCaP and PC-3 cells. PCNA-I1 also induces autophagy in PC-3 cells.
S4423 Emamectin Benzoate Emamectin Benzoate (EMB, MK-244) activates gamma-amino butyric acid (GABA) transporter. Emamectin Benzoate induces of reactive oxygen species (ROS)-mediated DNA damage and apoptosis.
S1334 Flupirtine maleate Flupirtine maleate is the salt form of Flupirtine, which is a centrally acting non-opioid analgesia, is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.
Assay Drug Dev Technol, 2019, 17(7):310-321
Elife, 2015, 4
S6909 Levomefolic acid Levomefolic acid (5-MTHF, LMSR, Metafolin, Nutrifolin) is a natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions.
S6997 CHAPS CHAPS is a zwitterionic surfactant that decreases the sequence specificity of the nucleosome.
S9603 Lurbinectedin Lurbinectedin, a DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity. Lurbinectedin inhibits RMG1 and RMG2 cell growth with IC50 of 1.25 nM and 1.16 nM, respectively.
E2939New Didox Didox (3,4-dihydroxy-benzohydroxamic acid) is a synthetic ribonucleotide reductase (RR) inhibitor derived from polyhydroxy-substituted benzohydroxamic acid. Didox inhibits proliferation of tamoxifen-resistant breast cancer cells.
E1596New AOH1996 AOH1996 is an orally active small-molecule PCNA inhibitor with potential anti-tumor activity. It enhances the interaction between PCNA and RPB1, the largest subunit of RNA polymerase II.
E0443New LDC195943 (IMT1) LDC195943 (IMT1) is a specific and noncompetitive inhibitor of human mitochondrial RNA polymerase (POLRMT). IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases.
E0444New LDC203974 (IMT1B) LDC203974 (IMT1B) is an orally active, noncompetitive and specific allosteric inhibitor of mitochondrial RNA polymerase (POLRMT) and inhibits mitochondrial DNA (mtDNA) expression. LDC203974 has anti-tumour effects.
E2921New Diethyl Pyrocarbonate Diethyl pyrocarbonate is a potent, non-specific inhibitor of RNase. It has been useful as an in vitro agent, relatively specific for binding to imidazole of histidine. It inhibits central chemosensitivity in rabbit and can modify Ser, Thr, His and Tyr residues.
E1529New ART812 ART812 is an orally active DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM.

DNA/RNA Synthesis阻害剤の選択性比較

Tags: DNA/RNA Synthesis inhibitor|DNA/RNA Synthesis agonist|DNA/RNA Synthesis activator|DNA/RNA Synthesis inducer|DNA/RNA Synthesis antagonist|DNA/RNA Synthesis signaling pathway|DNA/RNA Synthesis assay kit