Fludarabine

別名:FaraA, Fludarabinum, NSC 118218

Fludarabine is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis.

Fludarabine化学構造

CAS No. 21679-14-1

サイズ 価格(税別) 在庫状況
10mM (1mL in DMSO) JPY 29500 国内在庫あり
JPY 22000 国内在庫あり
JPY 55500 国内在庫あり
JPY 103500 国内在庫あり
JPY 220500 国内在庫なし(納期7~10日)

代表番号: 045-509-1970|電子メール:[email protected]
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製品安全説明書

現在のバッチを見る: 純度: 99.96%
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Fludarabine関連製品

シグナル伝達経路

STAT阻害剤の選択性比較

Cell Data

Cell Lines Assay Type Concentration Incubation Time 活性情報 PMID
EHEB Apoptosis Assay 40 μM 24 h induces apoptosis 23497075
HEC50B Apoptosis Assay 20/100 μM 24 h induces apoptosis slightly 23595697
AN3CA Apoptosis Assay 20/100 μM 24 h induces apoptosis in a dose-dependent manner 23595697
HEC1A Apoptosis Assay 20/100 μM 24 h induces apoptosis in a dose-dependent manner 23595697
HEC50B Growth Inhibition Assay 100-500 μM 24 h inhibits cell growth slightly 23595697
AN3CA Growth Inhibition Assay 100-500 μM 24 h inhibits cell growth in a dose-dependent manner 23595697
HEC1A Growth Inhibition Assay 100-500 μM 24 h inhibits cell growth in a dose-dependent manner 23595697
Reh Function Assay 10 μM 1/2/4 h induces autophagy 23681223
Nalm-6 Function Assay 10 μM 1/2/4 h induces autophagy 23681223
DU-145 Growth Inhibition Assay 0-10 μg/ml 48 h  inhibits cell growth in a dose-dependent manner 23734815
NALM6 Apoptosis Assay 5 μM 24 h induces cell apoptosis 24057147
I-83 Apoptosis Assay 5 μM 24 h induces cell apoptosis 24057147
BJAB Apoptosis Assay 5 μM 24 h induces cell apoptosis 24057147
HMECs  Function Assay 100 μM  36 h inhibits IFNα mediated phosphorylation of STAT1 and STAT3, but not of STAT2 24211327
HMECs Function Assay 100 μM  36 h inhibits IFNγ and LPS induced STAT1 phosphorylation and IRF1 expression 24211327
624.38mel  Function Assay 50-200 μM 24 h inhibits IDO activity independently of mRNA levels 24911872
MDA-231 Function Assay 50-200 μM 24 h inhibits IDO activity independently of mRNA levels 24911872
624.38mel  Function Assay 50 μM 24 h decreases IDO expression 24911872
MDA-231 Function Assay 100 μM 24 h decreases IDO expression 24911872
PBMC Function Assay 50/100 μM 24 h inhibits STAT1 phosphorylation 24911872
Raji  Function Assay 3 μM 24/48/72 h induces accumulations of p53, p63 and p73  24940695
KBM3/Bu2506 Apoptosis Assay 2.5 μM 48 h induces apoptosis slightly 25111583
MOLM 13 Apoptosis Assay 2.5 μM 48 h induces apoptosis slightly 25111583
THP-1 Apoptosis Assay 2.5 μM 48 h induces apoptosis slightly 25111583
MV-4-11 Apoptosis Assay 2.5 μM 48 h induces apoptosis slightly 25111583
Jeko-1  Function Assay 20 μM 24 h inhibits expression of IDO 25940712
CLL  Apoptosis Assay 10 μM  24-96 h induces apoptotic cell death 22207686
MEC1 Apoptosis Assay 100 μM 72 h induces apoptosis significantly 22132973
U937  Apoptosis Assay 0.8 μM 4-48 h induces apoptosis slightly 22074700
U937  Apoptosis Assay 1 μM 96 h induces apoptosis slightly 22023523
Daudi Apoptosis Assay 20 μM 96 h induces apoptosis slightly 22023523
J45.01 Apoptosis Assay 1 μM 96 h induces apoptosis slightly 22023523
NALM-6 Apoptosis Assay 10 μM  24 h induces cell apoptosis slightly 21699383
JMV-3 Apoptosis Assay 10 μM  24 h induces cell apoptosis slightly 21699383
EHEB Function Assay 5-50 μM 24 h decreases p21 expression significantly 21168391
JVM-2  Function Assay 30 μM 24 h decreases p21 expression 21168391
KBM3/Bu2506 Growth Inhibition Assay 0.6 μM 24 h increases the cell fraction in S-phase 20933509
HLE-B3  Function Assay 25 μM 48 h blocks IFN-γ–induced STAT1 phosphorylation and IDO expression 20435158
SKW6.4 Apoptosis Assay 0.01-10 μM 24/48 h induces cell death in both time- and dose- dependent manner 18092340
CCRF-CEM Function assay 10 uM 1 to 60 mins Drug transport in human CCRF-CEM cells assessed as ENT1-mediated uptake at 10 uM after 1 to 60 mins by liquid scintillation counting analysis 23388705
K562 Growth Inhibition Assay 72 h IC50=3.3 nM 20307198
RPMI 8226 Growth Inhibition Assay 24 h IC50=1.54 μM 17976186
MM.1S Growth Inhibition Assay 48 h IC50=13.48 μM 17976186
MM.1R Growth Inhibition Assay 48 h IC50=33.79 μM 17976186
CLL5 Antitumor assay 48 hrs Antitumor activity against CLL5 cells isolated from CLL patient assessed as cell viability after 48 hrs by FACS analysis, EC50 = 0.16 μM. 24673739
K562 Cytotoxicity assay 72 hrs Cytotoxicity against human paclitaxel-resistant K562 cells after 72 hrs by MTT assay, IC50 = 0.26 μM. 20605656
CLL3 Antitumor assay 48 hrs Antitumor activity against CLL3 cells isolated from CLL patient assessed as cell viability after 48 hrs by FACS analysis, EC50 = 0.35 μM. 24673739
CLL4 Antitumor assay 48 hrs Antitumor activity against CLL4 cells isolated from CLL patient assessed as cell viability after 48 hrs by FACS analysis, EC50 = 0.64 μM. 24673739
CEM-DNR-B Cytotoxicity assay 72 hrs Cytotoxicity against human CEM-DNR-B cells after 72 hrs by MTT assay, IC50 = 1.01 μM. 20605656
CLL6 Antitumor assay 48 hrs Antitumor activity against CLL6 cells isolated from CLL patient assessed as cell viability after 48 hrs by FACS analysis, EC50 = 1.6 μM. 24673739
CLL2 Antitumor assay 48 hrs Antitumor activity against CLL2 cells isolated from CLL patient assessed as cell viability after 48 hrs by FACS analysis, EC50 = 2.66 μM. 24673739
HCT116 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay, IC50 = 6.6 μM. 25462277
PBMC Cytotoxicity assay 48 hrs Cytotoxicity against patient PBMC after 48 hrs by CellTitre-Blue assay in presenc of mouse M210B4 cells, IC50 = 10 μM. 25562417
CLL1 Antitumor assay 48 hrs Antitumor activity against CLL1 cells isolated from CLL patient assessed as cell viability after 48 hrs by FACS analysis, EC50 = 17.1 μM. 24673739
CEM Cytotoxicity assay 72 hrs Cytotoxicity against human CEM cells after 72 hrs by MTT assay, IC50 = 19.49 μM. 20605656
T47D Cytotoxicity assay 72 hrs Cytotoxicity against human T47D cells after 72 hrs by SRB assay, IC50 = 46.2 μM. 25462277
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 47.44 μM. 20605656
Reh Growth Inhibition Assay IC50 ∼10 μM 23681223
Nalm-6 Growth Inhibition Assay IC50 ∼10 μM 23681223
Nalm-6-FluR Growth Inhibition Assay IC50=250 μM 25061101
Molt-4 Growth Inhibition Assay IC50=180 μM 25061101
RPMI-8226 Growth Inhibition Assay IC50=500 μM 25061101
Mec-1 Growth Inhibition Assay IC50>500 μM 25061101
U2937 Growth Inhibition Assay IC50=16 μM 25061101
Reh Growth Inhibition Assay IC50=30 μM 25061101
Nalm-6 Growth Inhibition Assay IC50=18 μM 25061101
A549 Growth Inhibition Assay IC50=15.7±2.8 µM 23377192
A549 GAPDH-deficient Growth Inhibition Assay IC50=18.5±2.3 µM 23377192
RPMI 8226 Growth Inhibition Assay IC50=25.9 ± 3.7 μM 21948264
CEM Growth Inhibition Assay IC50=2.4 ± 0.4 μM 21948264
Raji Growth Inhibition Assay IC50=0.47 ± 0.04 μM 21948264
U937 Growth Inhibition Assay IC50=0.24 ± 0.04 μM 21948264
K562 Growth Inhibition Assay IC50=0.44 ± 0.05 μM 21948264
KBM3/Bu2506 Growth Inhibition Assay IC20=0.67 µM 20933509
MDA-MB-231 Growth Inhibition Assay IC50=4.0 μM 20447390
MCF-7 Growth Inhibition Assay IC50=15.0 μM 20447390
BW-225 Growth Inhibition Assay IC20=1.37 ×10−8 μM  18661380
OH-65 Growth Inhibition Assay IC20=1.37 ×10−8 μM  18661380
GR-145 Growth Inhibition Assay IC20=2.74 × 10−8 μM  18661380
A549 Growth Inhibition Assay IC20=5.48 × 10−8 μM  18661380
CaSki  Growth Inhibition Assay IC20=1.37 × 10−7 μM  18661380
ZMK-1 Growth Inhibition Assay IC20=1.37 × 10−6 μM  18661380
U937 Growth Inhibition Assay IC50=3,200 ± 560 nM 15930361
primary CLL Cytotoxicity assay Cytotoxicity against human primary CLL cells, LD50 = 1.1 μM. 25148392
CHO Function assay Binding affinity determined by displacement of specific binding of [125I]N-(4-amino-3-iodophenethyl)-adenosine in membranes of CHO cells stably transfected with the rat adenosine A3 receptor, Ki = 10.4 μM. 7707320
JVM2 Antitumor assay Antitumor activity against human JVM2 cells assessed as cell viability after 48 hrs by FACS analysis, EC50 = 10.4 μM. 24673739
HeLa Antitumor assay Antitumor activity against human HeLa cells assessed as cell viability by MTT assay, EC50 = 16 μM. 24673739
TC32 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells 29435139
U-2 OS qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells 29435139
A673 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells 29435139
DAOY qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells 29435139
Saos-2 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells 29435139
BT-37 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells 29435139
RD qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells 29435139
SK-N-SH qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells 29435139
MG 63 (6-TG R) qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells 29435139
BT-12 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells 29435139
NB1643 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells 29435139
OHS-50 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells 29435139
BT-12 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-12 cells 29435139
LAN-5 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for LAN-5 cells 29435139
NB-EBc1 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB-EBc1 cells 29435139
SK-N-SH qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-SH cells 29435139
Rh41 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells 29435139
A673 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for A673 cells) 29435139
BT-37 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-37 cells 29435139
MG 63 (6-TG R) qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for MG 63 (6-TG R) cells 29435139
Rh30 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh30 cells 29435139
U-2 OS qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for U-2 OS cells 29435139
OHS-50 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for OHS-50 cells 29435139
SK-N-SH qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for SK-N-SH cells 29435139
RD qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for RD cells 29435139
Daoy qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for Daoy cells 29435139
TC32 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D caspase screen for TC32 cells 29435139
TC32 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for TC32 cells 29435139
MG 63 (6-TG R) qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for MG 63 (6-TG R) cells 29435139
SJ-GBM2 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells 29435139
SK-N-MC qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells 29435139
NB-EBc1 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells 29435139
LAN-5 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells 29435139
Rh18 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells 29435139
NB1643 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB1643 cells 29435139
SK-N-MC qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-MC cells 29435139
SJ-GBM2 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SJ-GBM2 cells 29435139
TC32 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for TC32 cells 29435139
Rh18 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh18 cells 29435139
Saos-2 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Saos-2 cells 29435139
SJ-GBM2 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for SJ-GBM2 cells 29435139
RD qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for RD cells 29435139
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生物活性

製品説明 Fludarabine is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis.
Targets
STAT1 [4]
(Vascular smooth muscle cells)
In Vitro
In vitro

Fludarabine efficiently inhibits the proliferation of RPMI 8226 cells with IC50 of 1.54 μg/mL. The IC50 of Fludarabine against MM.1S and MM.1R cells is 13.48 μg/mL and 33.79 μg/mL, respectively. In contrast, U266 cells are resistant to Fludarabine with IC50 of 222.2 μg/mL. Fludarabine treatment results in increased number of cells in the G1 phase of cell cycle, accompanied with a concomitant reduction of cells at the S phase of cell cycle in a time-dependent manner. Fludarabine induces a cell cycle block and triggers apoptosis in MM cells. Fludarabine triggers time-dependent cleavage of caspase-8, -9, and -3, -7, followed by PARP cleavage. Fludarabine increases expression of Bax in a time-dependent fashion, while the expression of Bak doesn't change. After exposure to Fludarabine for 12 hours, RPMI 8226 cells shows a loss of membrane potential with 61.05% of the cells expressing low fluorescence of rhodamine 123 compared with 8.62% of cells in untreated control. [1] To enhance solubility, Fludarabine is formulated as the monophosphate (F-ara-AMP, fudarabine), which is instantaneously and quantitatively dephosphorylated to the parent nucleoside upon intravenous infusion. Inside the cells rephosphorylation occurs which leads to fuoroadenine arabinoside triphosphate (F-ara-ATP), the major cytotoxic metabolite of F-ara-A. [2] Fludarabine can also induce pro-inflammatory stimulation of monocytic cells, as evaluated by increased expression of ICAM-1 and IL-8 release. [3] Fludarabine does not affect the growth of ovarian cancer cell lines, whereas it induces marked and dose-dependent inhibition of proliferation in melanoma cell lines. [4] Fludarabine is an inhibitor of STAT1 that specifically reduces STAT1 without affecting other STAT family members[5]. In addition to cytoplasmic accumulation, repeated low-dose cisplatin (RLDC) induces HMGB1 expression, which is marked suppressed by STAT1 knockdown. Consistently, fludarabine suppresses HMGB1 expression during RLDC treatment dose-dependently in RLDC-treat renal tubular cells[5].

細胞実験 細胞株 Dexamethasone-sensitive (MM.1S) and -resistant (MM.1R) human MM cell lines, RPMI8226 and U266 cell lines
濃度 2 μg/mL
反応時間 24 hours
実験の流れ

After treated with Fludarabine or control, dexamethasone-sensitive (MM.1S) and -resistant (MM.1R) human MM cell lines, RPMI8226 and U266 cell lines (5 × 105 cells) are washed twice in phosphate-buffered saline (PBS) and fixed with 70% ice-cold ethanol, then centrifuged and suspended in PBS containing 100 μg/mL RNase A. After incubated for 30 minutes at 37 ºC, samples are resuspended in 25 μg/mL propidium iodide. Flow cytometry is performed on a FACSCalibur automated system. Apoptosis is determined by Annexin V-FITC apoptosis detection kit, according to the manufacturer's instructions. For TUNEL (terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling) assay, cells are analyzed by flow cytometry using the in situ cell death detection kit.

実験結果図 Methods Biomarkers 結果図 PMID
Western blot procaspase-9 / procaspase-3 p-p53 / p53 STAT1 27223263
Immunofluorescence α-SMA / Vimentin 28322315
Growth inhibition assay Cell viability 24956101
In Vivo
In Vivo

Tumors treated with PBS grow rapidly to approx-imately 10-fold their initial volume in 25 day, whereas, the tumors in the Fludarabine at 40 mg/kg increase less than 5-fold. A significant antitumor effect of 40 mg/kg Fludarabine on RPMI8226 tumor growth is demonstrated. RPMI8226 tumors treated with 40 mg/kg Fludarabine at day 10 increase apoptotic nuclei. Fludarabine is effective in suppressing RPMI8226 myeloma xenografts in SCID mice. [1]

動物実験 動物モデル Severe combined immunodeficient (SCID) mice bearing RPMI 8226 cells
投与量 40 mg/kg
投与経路 Administered via i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05390814 Not yet recruiting
Primary Central Nervous System Lymphoma
Assistance Publique - Hôpitaux de Paris
February 15 2024 Phase 1
NCT05201183 Withdrawn
Acute Myeloid Leukemia|Chronic Myeloid Leukemia|Acute Lymphocytic Leukemia|Myelodysplastic Syndromes
Naoyuki G. Saito M.D. Ph.D.|Indiana University
October 2023 Phase 1|Phase 2
NCT05917405 Recruiting
Acute Myeloid Leukemia in Remission
Nantes University Hospital
September 14 2023 Phase 2
NCT05290662 Recruiting
AML
Glycostem Therapeutics BV
June 14 2022 --

化学情報

分子量 285.23 化学式

C10H12FN5O4

CAS No. 21679-14-1 SDF Download Fludarabine SDFをダウンロードする
Smiles C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)CO)O)O)F)N
保管

In vitro
Batch:

DMSO : 57 mg/mL ( (199.83 mM); 吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。)

Water : Insoluble

Ethanol : Insoluble

モル濃度計算器

in vivo
Batch:

Add solvents to the product individually and in order.

投与溶液組成計算機

実験計算

モル濃度計算器

質量 濃度 体積 分子量

投与溶液組成計算機(クリア溶液)

ステップ1:実験データを入力してください。(実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します)

mg/kg g μL

ステップ2:投与溶媒の組成を入力してください。(ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください)

% DMSO % % Tween 80 % ddH2O
%DMSO %

計算結果:

投与溶媒濃度: mg/ml;

DMSOストック溶液調製方法: mg 試薬を μL DMSOに溶解する(濃度 mg/mL, 注:濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )

投与溶媒調製方法:Take μL DMSOストック溶液に μL PEG300,を加え、完全溶解後μL Tween 80,を加えて完全溶解させた後 μL ddH2O,を加え完全に溶解させます。

投与溶媒調製方法:μL DMSOストック溶液に μL Corn oil,を加え、完全溶解。

注意:1.ストック溶液に沈殿、混濁などがないことをご確認ください;
2.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。

技術サポート

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Handling Instructions

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よくある質問(FAQ)

質問1:
how to re-suspend and deliver the inhibitor for in vivo experiments?

回答
For S1491, Fludarabine, we tested a vehicle: 30% Propylene glycol, 5% Tween 80, 65% D5W that you can resuspend the compound in at up to 30mg/ml. It's a suspension and can only be given via oral gavage.

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