Idelalisib (CAL-101, GS-1101)

製品コードS2226

Idelalisib (CAL-101, GS-1101)化学構造

分子量(MW):415.42

Idelalisib (CAL-101, GS-1101)は1種のセレクティブp110δ阻害剤です。無細胞試験で、IC50値は2.5 nMです。CAL-101 (Idelalisib, GS-1101)はp110δに表現する選択性はp110α/β/γに表現する選択性 より40-300倍が高くなって、C2β、hVPS34、DNA-PK とmTORに表現する選択性より400-4000倍が高くなります。

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文献中の引用(29)

カスタマーフィードバック(4)

  • Invasive migration of RA FLS was analyzed through growth factor–reduced Matrigel-coated transwell inserts in the presence or absence of 1 µM INK007, 5 µM CAL-101, or 0.3 µM IPI-145, or 0.3 µM GDC-0941 inhibitors or DMSO. Cells were allowed to invade through Matrigel toward PDGF-BB (25 ng/ml) containing media for 24 h and were fixed and stained with Hemacolor staining kit.

    J Immunol, 2014, 192(5): 2063-70 . Idelalisib (CAL-101, GS-1101) purchased from Selleck.

    293T cells were transfected with HA-tagged Fbxo45. At 48 h after transfection, cells were treated with AKT inhibitor (CAL-101; 10 uM, 4 h), cell extracts from the cytoplasm or nuclei were subjected to IP with anti-HA resin followed by western blot analysis with indicated antibodies.

    Cell Death Differ 2014 21(10), 1535-45. Idelalisib (CAL-101, GS-1101) purchased from Selleck.

  • Isoform-selective PI3K inhibitors blocked PI3K signaling in corresponding Rh30-Myr-p110 cells. Rh30-Myr-p110s cells were cultured in serum-free medium for 12 h, and then exposed to CAL-101 at indicated concentrations for additional 1 h. The cells were collected to detect the level of phosphorylated and total Akt. β-Actin was served as loading control.

    Acta Pharmacol Sin 2013 34(9),1201-7. Idelalisib (CAL-101, GS-1101) purchased from Selleck.

    After starved in serum-free medium for 24 h,A549 cells incubated with the indicated concentrations of CAL-101 for 3 h,followed by 20-minute stimolation of 100ng/ml EGF.

    Dr. Zhang of Tianjin Medical University. Idelalisib (CAL-101, GS-1101) purchased from Selleck.

製品安全説明書

PI3K阻害剤の選択性比較

生物活性

製品説明 Idelalisib (CAL-101, GS-1101)は1種のセレクティブp110δ阻害剤です。無細胞試験で、IC50値は2.5 nMです。CAL-101 (Idelalisib, GS-1101)はp110δに表現する選択性はp110α/β/γに表現する選択性 より40-300倍が高くなって、C2β、hVPS34、DNA-PK とmTORに表現する選択性より400-4000倍が高くなります。
ターゲット
p110δ [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
p110β [1]
(Cell-free assay)
p110α [1]
(Cell-free assay)
hVps34 [1]
(Cell-free assay)
2.5 nM 89 nM 565 nM 820 nM 978 nM
体外試験

CAL-101 is not sensitive to other PI3K class I subunits including p110α, p110β, and p110γ. CAL-101 specifically blocks FcϵR1 p110δ-mediated CD63 expression with an EC50 of 8 nM in primary basophil. CAL-101 exhibits greater activity in B-cell acute lymphoblastic leukemia (B-ALL) and chronic lymphocytic leukemia (CLL) cells compared with acute myeloid leukemia (AML) and myeloproliferative neoplasm (MPN) cells. CAL-101 produces the reduction in pAktS473, pAktT308, and the downstream target S6 in SU-DHL-5, KARPAS-422 and CCRF-SB cells with EC50 of 0.1 to 1.0 μM. [1] CAL-101 induces selective cytotoxicity in CLL cells independent of IgVH mutational status or interphase cytogenetics, primarily through a caspase-dependent mechanism. CAL-101 induces cytotoxicity preferentially to CLL cells compared with normal B cells, without producing cytotoxicity in other hematopoietic cells, compared to LY294002. CAL-101 lacks direct cytotoxic potential to T cells and nature killer (NK) cells. CAL-101 can inhibit production of inflammatory cytokines, such as IL-6, IL-10, TNF-α, and IFN-γ, and activation-induced cytokines, such as CD40L. CAL-101 also antagonizes CD40L-mediated CLL cell survival. [2] CAL-101 induces an accumulation of cells in G1 and a decrease in the S-phase population in L1236 and L591 cells, which indicates CAL-101 as a novel strategy for the treatment of hodgkin lymphoma (HL). [3]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MEC1 M3nkWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDCZoJFVVOR MnHSTWM2OD1{MD60JO69VQ>? MoHCNlU6QTl|NUK=
CLL PBMCs NFr4THRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HHV2ROW09? MWDJR|UxRTJwOTDuUS=> NGfQVlEzPTlzN{K2Oy=>
U266 NFn5U41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljLOFAh|ryP NEXLdpg1QCCq NEjJVYk4QS53JTDpcohq[mm2aX;uJJJifGV? MkDkNlU{Ozl|M{K=
K562 MWXGeY5kfGmxbjDBd5NigQ>? M4TLcFEh|ryP M1PQNVMhcA>? NFPoOJJKdmirYnn0bY9vKG:oIFHreEBxcG:|cHjvdplt[XSrb36= Mlv2NlUxOTR5N{W=
K562 MoPtSpVv[3Srb36gRZN{[Xl? MVixJO69VQ>? MYKzJIg> M1HqcGlvcGmkaYTpc44hd2ZiUEewV|ZMKHCqb4PwbI9zgWyjdHnvci=> NXTnVHp4OjVyMUS3O|U>
K562 M3PPWWZ2dmO2aX;uJGF{e2G7 MX2xJO69VQ>? M3nQdFMhcA>? Mn\HTY5pcWKrdHnvckBw\iCJU1uzJJBpd3OyaH;yfYxifGmxbh?= M3;KSFI2ODF2N{e1
K562 NEPLNYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NICzN5MyKM7:TR?= NH3mUYc4OiCq M3jHSWlvcGmkaYTpc44hd2ZicILvcIln\XKjdHnvci=> MV:yOVAyPDd5NR?=
Primary AML cell MWrGeY5kfGmxbjDBd5NigQ>? MkSzNUDPxE1? MUOzJIg> MVrJcohq[mm2aX;uJI9nKEGtdDDwbI9{eGixconsZZRqd25? NHjjWmMzPTBzNEe3OS=>
Primary AML cell M3vBcWZ2dmO2aX;uJGF{e2G7 M1vNVVEh|ryP M2nXdVMhcA>? MVHJcohq[mm2aX;uJI9nKFB5MGO2T{BxcG:|cHjvdplt[XSrb36= MnW3NlUxOTR5N{W=
Primary AML cell MVzGeY5kfGmxbjDBd5NigQ>? M1LrcVEh|ryP M1zRS|MhcA>? MY\Jcohq[mm2aX;uJI9nKEeVS{OgdIhwe3Cqb4L5cIF1cW:w NYTwUo86OjVyMUS3O|U>
Primary AML cell M{ntU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUeySZFxOSEQvF2= NHLOXoI{KGh? NFWzdG9UfXCycnXzd4lwdiCxZjDyVm5CKHO7boTo[ZNqew>? MUeyOVAyPDd5NR?=
Microglia M4HnSWZ2dmO2aX;uJGF{e2G7 MYS1JO69VQ>? NWPBSmtrOTBiaB?= NV;peZdwTE2VTx?= MVPE[YNz\WG|ZTDv[kBVVk[jIIPlZ5JmfGmxbjDmdo9uKEySUz3zeIlufWyjdHXkJEBxOTFyzsTEPVExSS:GOUGwRUBucWO{b3fsbYE> M1nm[FI1PjJ3Nki0
Primary CLL cell NHXUbohHfW6ldHnvckBCe3OjeR?= M4n1WVEh|ryP MWixOUBucW5? Mo[2SG1UVw>? MYTCcI9kc3NiQlPSMYlv\HWlZXSgUGNROSC|ZYLpcoUuPSCjY4TpeoF1cW:w MVqyOFAxQTJ|Mx?=
JEKO-1 Ml;qSpVv[3Srb36gRZN{[Xl? NUDHTFhJOSEQvF2= Mmj5O|IhcA>? NYjKbI1NUW6qaXLpeIlwdiCxZjDBb5QheGixc4Doc5J6dGG2aX;uJIlvKEmpTT3zeIlufWyjdHXkJGpGU09vMR?= M1m4VVI{OzRzNUSx
Granta-519 NEPPSVhHfW6ldHnvckBCe3OjeR?= MkLRNUDPxE1? MYqyJIg> M3P5emlvcGmkaYTpc44hd2ZiQXv0LJQ{ODhrIIDoc5NxcG:{eXzheIlwdg>? M2fxPVI{OzRzNUSx
Granta-519 M1GwNGZ2dmO2aX;uJGF{e2G7 NYPjZ5FVOSEQvF2= M4HHXlIhcA>? M4XDeGlvcGmkaYTpc44hd2ZiQXv0LJM1PzNrIIDoc5NxcG:{eXzheIlwdg>? MoTENlM{PDF3NEG=
JEKO-1 NISzdlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{D1eVExKM7:TR?= NEfuU|Q4OiCq MWjJcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36gd4xq\2i2bIm= NFKwdWczOzN2MUW0NS=>
JEKO-1 Mln4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITlNmo2KM7:TR?= M1\LZVczKGh? NHfTWoFld2W|IH7veEBqdmS3Y3WgZ4VtdCCleXPs[UBienKnc4Sgc5Ih[XCxcITvd4l{ NEDFN5AzOzZ5NkKyNC=>
MAVER-1 MlHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInFNHc2KM7:TR?= NHrYfpQ4OiCq MXnkc4V{KG6xdDDpcoR2[2ViY3XscEBkgWOuZTDhdpJme3Rib4KgZZBweHSxc3nz M4PHOlI{Pjd4MkKw
MINO MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HRXVUh|ryP M2\sUVczKGh? Mnu5[I9meyCwb4SgbY5lfWOnIHPlcIwh[3mlbHWgZZJz\XO2IH;yJIFxd3C2b4Ppdy=> MoLUNlM3PzZ{MkC=
SP53 M3XZUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfR[lF[OC5zIN88US=> Ml\6O|IhcA>? NXHtTYhp\G:nczDuc5QhcW6mdXPlJINmdGxiY4njcIUh[XK{ZYP0JI9zKGGyb4D0c5Nqew>? NFKwfJczOzZ5NkKyNC=>
HH NGHQb4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF6xO2syOCEQvF2= NI\kXZQ4OiCq MY\EUXNQ MkH0TY5lfWO2aX;uJI9nKGGyb4D0c5NqeyC|bHnnbJRtgQ>? NH23WnIzOjhyMUm1PS=>
Myla NV\McZVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPENVAh|ryP M1\FOFczKGh? MkL5SG1UVw>? NWTKOHhb\G:nczDuc5QhcW6mdXPlJIFxd3C2b4Ppdy=> MWCyNlgxOTl3OR?=
SR786 NYTxS2NjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY[xNEDPxE1? NF3ZU5I4OiCq M4TtW2ROW09? MXvkc4V{KG6xdDDpcoR2[2ViYYDvdJRwe2m| NVPwVlFOOjJ6MEG5OVk>
HuT78 NFXwcIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTkNVAh|ryP NXPq[lBvPzJiaB?= M4O3SWROW09? MULkc4V{KG6xdDDpcoR2[2ViYYDvdJRwe2m| NXvqTFlvOjJ6MEG5OVk>
MJ NIrodYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrHNVAh|ryP MVS3NkBp NF\BV5FFVVOR NX2xTZI2\G:nczDuc5QhcW6mdXPlJIFxd3C2b4Ppdy=> MViyNlgxOTl3OR?=
DERL7 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfYbGwxOTBizszN NVmxRmFpPzJiaB?= NIizfFhFVVOR M{TScYRw\XNibn;0JIlv\HWlZTDhdI9xfG:|aYO= MYKyNlgxOTl3OR?=
L1236 MVLGeY5kfGmxbjDBd5NigQ>? NYi4TZpHOTBizszN NWnCSYd3OiCq NGL5[|dKdmirYnn0bY9vKG:oIFHreEBxcG:|cHjvdplt[XSrb36= NVn4dWhGOjJ{MUC4O|c>
L428 NID5SoVHfW6ldHnvckBCe3OjeR?= NY\ISmlPOTBizszN MnjINkBp M1SwNGlvcGmkaYTpc44hd2ZiQXv0JJBpd3OyaH;yfYxifGmxbh?= MViyNlIyODh5Nx?=
L591 MoizSpVv[3Srb36gRZN{[Xl? MkjkNVAh|ryP MVmyJIg> MWnJcohq[mm2aX;uJI9nKEGtdDDwbI9{eGixconsZZRqd25? NYTLNINHOjJ{MUC4O|c>
KMH-2 MXrGeY5kfGmxbjDBd5NigQ>? NX[5d3NlOTBizszN MVGyJIg> MWLJcohq[mm2aX;uJI9nKEGtdDDwbI9{eGixconsZZRqd25? NEXGSHYzOjJzMEi3Oy=>
L1236 M{m1R2Z2dmO2aX;uJGF{e2G7 M2fUdFUh|ryP MlTFNlQhcA>? NW[1[5FuSmyxY3vzJJNm[3KndHnvckBw\iC2aHWgR2NNPQ>? MoXnNlIzOTB6N{e=
L591 NHzsdYdHfW6ldHnvckBCe3OjeR?= MYm1JO69VQ>? M4X2eVI1KGh? NUHHPWlVSmyxY3vzJJNm[3KndHnvckBw\iC2aHWgR2NNPQ>? MXiyNlIyODh5Nx?=
L1236 NFPGRppCeG:ydH;zbZMhSXO|YYm= NVrQ[G86PSEQvF2= NFzjTWszPCCq NXzKdFJHUW6mdXP0bY9vKG:oIHHwc5B1d3Orcx?= NHzsW4ozOjJzMEi3Oy=>
L591 MWPBdI9xfG:|aYOgRZN{[Xl? MkfNOUDPxE1? MnfJNlQhcA>? NF\lcpRKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m| M4\hOVIzOjFyOEe3
U-87MG NXy0cXFqTnWwY4Tpc44hSXO|YYm= NGLFSXUyODBibl2= NXja[GZEOjRiaB?= MWDEUXNQ MmHZTY5pcWKrdHnvckBw\iBiY3XscEBucWe{YYTpc44> Mo\GNlIxPzl4MEm=
SW1783 NHPSe|FHfW6ldHnvckBCe3OjeR?= NWPpd|N4OTByIH7N MWeyOEBp NH\jTG9FVVOR NGXW[o9KdmirYnn0bY9vKG:oIDDj[YxtKG2rZ4LheIlwdg>? M3LhS|IzODd7NkC5
U-87MG MWfGeY5kfGmxbjDBd5NigQ>? NEjKd4g2KM7:TR?= NVnxNFRNOjRiaB?= MlvvSG1UVw>? NFjiUJZKdmirYnn0bY9vKG:oIFHreEBxcG:|cHjvdplt[XSrb36gd5Vje3SjboTpZYxtgQ>? NELIdYEzOjB5OU[wPS=>
SW1783 MWfGeY5kfGmxbjDBd5NigQ>? MYS1JO69VQ>? M3rWPVI1KGh? NXm1cJBpTE2VTx?= MmP5TY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:wIIP1ZpN1[W62aXHscJk> MknrNlIxPzl4MEm=
U-373MG M2PXVmZ2dmO2aX;uJGF{e2G7 M1HOUVUh|ryP M3P5clI1KGh? NX3GbZhwTE2VTx?= MnfGTY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:wIIP1ZpN1[W62aXHscJk> MUGyNlA4QTZyOR?=
SK-MG3 NWTOSmdRTnWwY4Tpc44hSXO|YYm= MkW0OUDPxE1? NWezNXhEOjRiaB?= NGDKVYFFVVOR MVHJcohq[mm2aX;uJI9nKEGtdDDwbI9{eGixconsZZRqd25ic4Xid5RidnSrYXzsfS=> M{\U[|IzODd7NkC5
SU-DHL-5 MkLRSpVv[3Srb36gRZN{[Xl? NX7MNFFVOSEQvF2= NYPPfnI6OjRiaB?= NVvhSFUxTE2VTx?= Ml7hTY5lfWO2aX;uJI9nKGGyb4D0c5Nqew>? Mo\kNlA6PTl4ME[=
WSU-NHL NE[1XZhHfW6ldHnvckBCe3OjeR?= MmPJNUDPxE1? Ml71NlQhcA>? MojoSG1UVw>? NGHae2FKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m| NX:xdHBlOjB7NUm2NFY>
CCRF-SB MXLGeY5kfGmxbjDBd5NigQ>? M2HWPVEh|ryP NFX1RnMzPCCq MnO0SG1UVw>? M2\OXmlv\HWldHnvckBw\iCjcH;weI9{cXN? NVixU|hYOjB7NUm2NFY>
INA-6 MX7GeY5kfGmxbjDBd5NigQ>? M4[z[FUh|ryP NVfyc5NUPiCq MU\Jcohq[mm2aX;uJI9nKFCLM1uvRYt1KGGwZDDFVmsheGG2aIfhfS=> MUeyNFUxPTF3OB?=
LB MYfGeY5kfGmxbjDBd5NigQ>? M3zsSFUh|ryP NF\lWGI3KGh? NXu2R2hpUW6qaXLpeIlwdiCxZjDQTVRMN0GtdDDhcoQhTVKNIIDheIh4[Xl? MVyyNFUxPTF3OB?=

多くの細胞株試験データを見る場合、クリックしてください

お薦めの試験操作(参考用のみ)

キナーゼ試験:[2]
+ 展開

PI3K assay:

PI3K assay is preformed on whole-cell lysates from CLL or normal B cells. A PI3K ELISA assay is performed. Briefly, whole-cell extracts are added to a mixture of PI(4,5)P2 substrate and reaction buffer containing adenosine triphosphate (ATP) and allowed to incubate at room temperature. The reaction is stopped by adding PI(3,4,5)P3 detector mixed with EDTA (ethylenediaminetetraacetic acid) and allowed to incubate at room temperature for 1 hour. After this time, the mixture is transferred from each well to a PI3K ELISA plate and allowed to incubate 1 hour. Plates are washed and then incubated with secondary detector for 30 minutes. Plates are washed again, and 3,3′,5,5′-tetramethylbenzidine solution is added for 5 minutes at which time H2SO4 is added to stop all reactions. Plates are read at 450 nm on a Labsystems 96-well plate reader.
細胞試験: [2]
+ 展開
  • 細胞株: CLL B cells or healthy volunteer T cells or NK cells
  • 濃度: 0.01-100 μM
  • 反応時間: 48 hours
  • 実験の流れ: MTT assays are performed to determine cytotoxicity. 1 × 105 cells are incubated with CAL-101. MTT reagent is then added, and plates are incubated for an additional 20 hours before washing with protamine sulfate in phosphate-buffered saline. DMSO is added, and absorbance is measured by spectrophotometry at 540 nm in a Labsystems plate reader. Cell viability is also measured at various time points with the use of annexin/PI flow cytometry. Data are analyzed. At least 104 cells are counted for each sample. Results are expressed as the percentage of total positive cells over untreated control. Experiments examining caspase-dependent apoptosis included the addition of 100 μM Z-VAD. Experiments examining survival signals include the addition of 1 μg/mL CD40L, 800 U/mL IL-4, 50 ng/mL BAFF, 20 ng/mL TNF-α, or coculturing on fibronectin or stromal (HS-5 cell line) coated plates. Stromal coculture is done by plating a 75-cm2 flask (80%-100% confluent) per 6-well plate 24 hours before the addition of CLL cells.
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 83 mg/mL (199.79 mM) warming
Ethanol 23 mg/mL (55.36 mM)
Water slightly soluble or insoluble
体内 順序で溶剤を入れること:
30% PEG 400 (dissolve first)+0.5% Tween 80+5% Propylene glycol
30mg/mL

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 415.42
化学式

C22H18FN7O

CAS No. 870281-82-6
保管
in solvent
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02457598 Recruiting B-cell Malignancies Gilead Sciences June 30, 2015 Phase 1
NCT02962401 Not yet recruiting Waldenstrom Macroglobulinemia French Innovative Leukemia Organisation January 2017 Phase 2
NCT02928510 Not yet recruiting Absence of Signs or Symptoms|B-Cell Non-Hodgkin Lymphoma|Digestive System Signs and Symptoms|Indolent Adult Non-Hodgkin Lymphoma|Recurrent B-Cell Non-Hodgkin Lymphoma|Recurrent Chronic Lymphocytic Leukemia|Recurrent Indolent Adult Non-Hodgkin Lymphoma|Recurrent Small Lymphocytic Lymphoma Jonsson Comprehensive Cancer Center|Gilead Sciences|National Cancer Institute (NCI) January 2017 --
NCT02968563 Recruiting Chronic Lymphocytic Leukemia Gilead Sciences|German CLL Study Group December 2016 Phase 2
NCT02639910 Recruiting Leukemia, Lymphocytic, Chronic, B-Cell|Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma MorphoSys AG November 2016 Phase 2
NCT02970318 Recruiting Chronic Lymphocytic Leukemia Acerta Pharma BV September 2016 Phase 3

技術サポート

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よくある質問(FAQ)

  • 問題1:

    What is the recommended dose of CAL-101 and the route of administration for mouse studies?

  • 回答:

    According to the following paper, S2226 can be used by I.V. administration at the concentration of 40 mg/kg. http://www.ncbi.nlm.nih.gov.ezproxy.liv.ac.uk/pubmed/?term=PI3K%CE%B4+inhibition+reduces+TNF+secretion+and+neuroinflammation+in+a+mouse+cerebral+stroke+model

PI3K信号経路図

PI3K Inhibitors with Unique Features

相関PI3K製品

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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID