Pictilisib (GDC-0941)

製品コードS1065 別名:RG7321

Pictilisib (GDC-0941)化学構造

分子量(MW):513.64

Pictilisib (GDC-0941)は1種の有効なPI3Kα/δ阻害剤です。無細胞試験で、Pictilisib (GDC-0941)はPI3Kα/δに作用する時の IC50値は 3 nM で、p110β (11倍) とp110γ (25倍)に適合な選択性をしています。臨床2期。

サイズ 価格(税別) 在庫  
JPY 39840.00 あり
JPY 19920.00 あり
JPY 28220.00 あり
JPY 61420.00 あり
JPY 161020.00 あり

文献中の使用例(58)

カスタマーフィードバック(8)

  • Dual PI3K/BRAF inhibition upregulates BIM and enhances apoptosis in PTEN cells. A, left, Western blot of 1205Lu cells treated with PLX4720 (3 μmol/L, 48 hours), the PI3K inhibitor GDC-0941 (3 μmol/L, 48 hours), or both drugs in combination (PtG); right, immunofluorescence staining of BIM (green) and DAPI (blue) in PTEN cells following PLX4720 treatment (3 μmol/L, 48 hours), the PI3K inhibitor LY294002 (10 μmol/L, 48 hours), or both drugs in combination (PLXtLY). B, left, immunofluorescence staining of PTEN 1205Lu following combined inhibition (3 μmol/L PLX4720 t 10 μmol/L LY294002, 48hours) increases nuclear localization of FOXO3a (green). DAPI is shown in blue. Magnification 40. Right, combined inhibition (3 μmol/L PLX4720 t 10 μmol/L LY294002, 48 hours) increases PTEN WM793 BIM mRNA levels to those observed with single BRAF inhibition (3 μmol/L PLX4720, 48 hours) in the PTENt WM35. C, PTEN cells were treated with PLX4720 (3 μmol/L, 48 hours), GDC-0941 (3 μmol/L, 48hours), or a combination of the 2 drugs (3Pt3G) before Annexin-V staining was analyzed by flow cytometry (*, P < 0.05 between the drug combination and each inhibitor alone). D, combined BRAF/PI3K inhibitor treatment blocks the escape of 1205Lu cells (PTEN) from therapy. Spheroids of 1205Lu cells were treated with either PLX4720 alone (3 and 10 μmol/L: data shows 3 mmol/L), LY294002 (10 μmol/L) alone or a combination of the 2 drugs for 72 hours. In other studies, spheroids were treated with drugs for 72 hours and then allowed to recover for 120 hours. Micrograph shows viability staining (green= live cells, red= dead cells). Magnification 10×.

    Cancer Res 2011 71, 2750-2760. Pictilisib (GDC-0941) purchased from Selleck.

    Combination of rapamycin and PI-103 leads to the suppression of AKT phosphorylation (phospho-specific western blot). Mel-Juso and 518A2 cells were treated with GDC-0941 from 0.05–1 μmol/L alone and in combination with rapamycin (50 nmol/L) for 24 hours. Control treatment was with DMSO.

     

     

    J Inves Der 2010 131, 495-503. Pictilisib (GDC-0941) purchased from Selleck.

  • Growth inhibition induced by the FGFR inhibitor BGJ398 and the PI3K inhibitors alone or in combination. AN3CA (A-C), JHUEM2 (D-F) and MFE296 (G-I) cells were treated with the indicated doses of BGJ398, GDC-0941 a n d BYL719 alone or in combination for 96 hours and an Sulforhodamine B (SRB) assay was subsequently performed. Data are presented as a percentage of the control, in which cells were treated with 0.1% (v/v) DMSO. Points represent the mean of three independent experiments (each performed in triplicate). Error bars represent the standard error of the mean (SEM) and lines were fitted using non-linear regression analysis. Interaction of BGJ398 and GDC-0941(redcircles) or BYL719(blacksquares) in AN3CA(C), JHUEM2(F) and MFE296(I). Median effect analysis was used to evaluate the interaction between the inhibitor combinations. Horizontal dotted lines indicate the boundaries for each interaction classification.

    Mol Cancer Ther, 2017.. Pictilisib (GDC-0941) purchased from Selleck.

    TGF-β induces mTORC2 activation. ( A ) NMuMG cells were treated with TGF-β for the indicated times before lysis and immunoblotting. (B ) NMuMG cells were treated or not with TGF-β for the indicated times, in the presence or absence of SB431542 or LY294002. Cell lysates were subjected to anti-Rictor immunoprecipitation, and the immunoprecipitates were subjected to in vitro kinase assays using kinase-inactive Akt1 as a substrate, before immunoblotting of the kinase reactions, immunoprecipitates and cell lysates. The left panels are from the same gel, without differential exposure. ( C ) NMuMG cells were treated or not with TGF-β or insulin for the indicated times, in the presence or absence of SB431542 or GDC-0941. The kinase activity of mTORC2 was then assessed as in B. The top panels are from the same gel, without differential exposure. (D) NMuMG cells were treated or not with TGF-β for the indicated times, in the presence or absence of SB431542 or LY294002. Cell lysates were subjected to immunoprecipitation using Rictor antibody, and/or immunoblotted.

    J Cell Sci 2012 125(Pt 5), 1259-73. Pictilisib (GDC-0941) purchased from Selleck.

  • After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of GDC-0941  for 3h,followed by 15-minute  stimulation of 100ng/ml EGF.

     

     

     

    Dr. Zhang of Tianjin Medical University. Pictilisib (GDC-0941) purchased from Selleck.

    We treated all of drugs in T47D which has a PI3KCA H1044R mutation with the concentration shown below for 1 hour and performed western blot analysis using antibodies to phospho-AKT(SERINE 472), and total AKT.

     

     

    Saraswati Sukumar of Johns Hopkins University School of Medicine. Pictilisib (GDC-0941) purchased from Selleck.

  • Effects of LY294002 and GDC-0941 on the high-glucose-induced plasma membrane translocation of DGK δ1. (A, C) HEK293 cells were transfected with pAcGFP-DGKδ1 or pAcGFP-C1 vector. After being glucose-starved for 2.5 h and the subsequent pretreatment with (A) 10 μM LY294002 (Sigma-Aldrich) or (C) 1 μM GDC-0941 (Selleck Chemicals) for 30 min, the cells were incubated with or without high glucose (25 mM) for 5 min. The cells were fixed with 3.7% formaldehyde and observed using confocal laser-scanning microscopy. Scale bar = 10 μm. (B, D) After treatment with (B) LY294002 or (D) GDC-0941, the percentages of cells exhibiting the translocation of AcGFP-tagged DGK δ 1 to the plasma membrane were scored. More than 20 cells ex-pressing AcGFP-tagged DGK δ1 were counted in each experiment. The results are the means ± S.D. of three independent experiments. The statistical significance was deter-mined using Student's t -test (** P < 0.01, *** P < 0.005)

    Biochim Biophys Acta 2012 1823, 2210-6. Pictilisib (GDC-0941) purchased from Selleck.

     

    PI3K pathway signaling in GDC-0941 and MK-2206 treated MCF-7 derivatives with PIK3CA or  AKT1 mutations. Cells were grown in medium containing 5% FBS and treated with vehicle or increasing concentrations of GDC-0941 (0 nM, 50 nM, 100 nM, and 400 nM) or MK-2206 (0 nM, 100 nM, 250 nM, 1000 nM). After 24 hours of drug treatment, lysates were prepared and equal amounts of protein were load ed onto SDS-PAGE gels and blotted with the indicated antibodies.

    Pictilisib (GDC-0941) purchased from Selleck.

製品安全説明書

PI3K阻害剤の選択性比較

生物活性

製品説明 Pictilisib (GDC-0941)は1種の有効なPI3Kα/δ阻害剤です。無細胞試験で、Pictilisib (GDC-0941)はPI3Kα/δに作用する時の IC50値は 3 nM で、p110β (11倍) とp110γ (25倍)に適合な選択性をしています。臨床2期。
ターゲット
p110α [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
p110β [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
3 nM 3 nM 33 nM 75 nM 0.58 μM(Ki app)
体外試験

GDC-0941 is equipotent against PI3Kα and PI3Kδ as well as PI3Kα mutants E545-K and H1047-R, displaying modest levels of selectivity against PI3Kβ (10-fold) and PI3Kγ (25-fold), and greater levels of selectivity against members of PI3K class II, III, and IV, including C2β, Vps34, DNA-PK, and mTOR. GDC-0941 potently inhibits the phosphorylation of Akt in U87MG, PC3, and MDA-MB-361 cells with IC50 of 46 nM, 37 nM, and 28 nM, respectively. GDC-0941 inhibits the proliferation of U87MG, A2780, PC3, and MDA-MB-361 cells with IC50 of 0.95 μM, 0.14 μM, 0.28 μM, and 0.72 μM, respectively. [1] GDC-0941 treatment potently inhibits the proliferation of both trastuzumab-sensitive and -insensitive HER2-amplified cells with IC50 of 149-944 nM. GDC-0941 inhibits proliferation of HER2-amplified cells that harbor PIK3CA mutations with IC50 of <500 nM, and effectively inhibits both proliferation and viability of HER2-amplified breast cancer cells that are resistant to trastuzumab due to PTEN loss. [2] GDC-0941 significantly inhibits the growth of HCT116, DLD1 and HT29 cells with GI50 of 1081 nM, 1070 nM and 157 nM, respectively. [3] GDC-0941 inhibits tumor cell proliferation, induces apoptosis and suppresses centroblast population. [4]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 MXvLbY5ie2ViQYPzZZk> NVryUJR2OSCq M3TOZ2ROW09? NG\GRplKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHTlcJRiKGW6cILld5Nm\CCrbjDT[lkh[2WubIOgZ49mgHC{ZYPzbY5oKHB6NXHsdIhiKHerdHigTWM2OCCxZjCwMlAxOyEQvF2= M1fvT|E5PzV2NkW0
Sf9 MlXqT4lv[XOnIFHzd4F6 NYnkSlY5OSCq Ml3QSG1UVw>? NHTHVXdKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHLleIEhUDFyNEetVkBufXSjboSg[ZhxemW|c3XkJIlvKFOoOTDj[YxteyClb3X4dJJme3OrbnegdFg2[WyyaHGge4l1cCCLQ{WwJI9nKDBwMECzJO69VQ>? NEfpRnkyQDd3NE[1OC=>
Sf9 M2DPc2tqdmG|ZTDBd5NigQ>? NIT3dVIyKGh? NHrz[HdFVVOR M1;kWWlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiUFmzT{BxOTFyYnX0ZUBGPTR3LVugcZV1[W62IHX4dJJme3OnZDDpckBU\jliY3XscJMh[2:neIDy[ZN{cW6pIIC4OYFteGijIIfpeIghUUN3MDDv[kAxNjByMzFOwG0> NYTiUVdSOTh5NUS2OVQ>
Sf9 MYDLbY5ie2ViQYPzZZk> M3jRdVEhcA>? M3TP[WROW09? MXzJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGKndHGg[ZhxemW|c3XkJIlvKFOoOTDj[YxteyClb3X4dJJme3OrbnegdFg2[WyyaHGge4l1cCCLQ{WwJI9nKDBwMEOzJO69VQ>? M2HYcFE5PzV2NkW0
Sf9 NH7mOY9McW6jc3WgRZN{[Xl? NEjZPYsyKGh? MWPEUXNQ MYLJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGGucHjhJIV5eHKnc4Pl[EBqdiCVZkmgZ4VtdHNiY3;lfJBz\XO|aX7nJJA5PWGucHjh M2i3ZlE5PzV2NkW0
MDA-MB-361 Ml\4SpVv[3Srb36gRZN{[Xl? MljINkBp M{fqPGROW09? NF;uT5NKdmirYnn0bY9vKG:oIFHreEBU\XJ2N{OgdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIF3ERU1OSi1|NkGgZ4VtdHNid3n0bEBRUUt|Q1GgSVU1PS2NIH31eIF1cW:wIIfpeIghUUN3MDDv[kAxNjB{ODFOwG0> NHG0PYYyQDd3NE[1OC=>
PC3 NHvTO|hHfW6ldHnvckBCe3OjeR?= M1HGU|IhcA>? MVTEUXNQ NX6zVWQ5UW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbjDpckBRXEWQLX71cIwhcHWvYX6gVGM{KGOnbHzzJJdqfGhiSVO1NEBw\iByLkCzO{DPxE1? NF;HVYcyQDd3NE[1OC=>
U87MG MUjGeY5kfGmxbjDBd5NigQ>? MWKyJIg> Mn\QSG1UVw>? NEHaepJKdmirYnn0bY9vKG:oIFHreEBU\XJ2N{OgdIhwe3Cqb4L5cIF1cW:wIHnuJHBVTU5vboXscEBpfW2jbjDVPFdOTyClZXzsd{B4cXSqIFnDOVAhd2ZiMD6wOFYh|ryP M3LhPVE5PzV2NkW0
MDA-MB-361 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILleZI6PiCq NYPLb4xGTE2VTx?= MoPDRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOzZzIHPlcIx{KHerdHigVGlMO0ODIFW1OFUuUyCvdYTheIlwdiC5aYToJGlEPTBib3[gNE44OiEQvF2= MUixPFc2PDZ3NB?=
A2780 MnLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XWPFk3KGh? NFnu[VBFVVOR M1LYfmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUK3PFAh[2WubIOge4l1cCCSSVuzR2Eh[W6mIGDUSW4hdXW2YYTpc44hf2m2aDDJR|UxKG:oIECuNVQh|ryP MV[xPFc2PDZ3NB?=
PC3 NIi4TmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7rPVYhcA>? NGrWRoVFVVOR NX7N[3hqUUN3ME2wMlI5KM7:TR?= NIfR[nMyQDd3NE[1OC=>
U87MG NF:xVJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DsO|k3KGh? NYrzeJZJTE2VTx?= Mlu1TWM2OD1yLkm1JO69VQ>? M2rFWVE5PzV2NkW0
Sf9 M3TZfmtqdmG|ZTDBd5NigQ>? NGrkbIE{OCCvaX6= MWLEUXNQ MUXJcohq[mm2aX;uJI9nKGi3bXHuJHBKO0upYX3tZUBmgHC{ZYPz[YQh[XO|ZYPz[YQh[XNiYX3veY51KG:oIFHUVEBkd26|dX3l[EB4cXSqIFnDOVAhd2ZiMD6wOFIh|ryP NYKwOWJxOjJ3NEizOFI>
RAW 264.7 Mmj0T4lv[XOnIFHzd4F6 MlTBPVAhdWmw MUHEUXNQ NGT5ZWxKdmirYnn0bY9vKG:oIHj1cYFvKFCLM1vnZY1u[SCneIDy[ZN{\WRiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCDS2SgdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAxNjJ7ODFOwG0> M{HEWlIzPTR6M{Sy
Sf9 Ml;zT4lv[XOnIFHzd4F6 NFW0XHQyKGh? NXfLNmoxUW6qaXLpeIlwdiCxZjDHV3Qu\nW|ZXSgbJVu[W5icnXjc41jcW6jboSgVGk{U2KndHGg[ZhxemW|c3XkJIlvKGKjY4Xsc5ZqenW|IHnu[oVkfGWmIGPGPUBk\WyuczD3bZRpKEmFNUCgc4YhOC5yMUeg{txO NXTIXG9VOjN3NEC2OFU>
Sf9 MnLtT4lv[XOnIFHzd4F6 Mo\GNUBp M1PifmlvcGmkaYTpc44hd2ZiR2PUMYZ2e2WmIHj1cYFvKHKnY3;tZolv[W62IGDJN2tl\Wy2YTDlfJBz\XO|ZXS= M2XmZ|I{PTRyNkS1
Sf9 NUG4fXQ1U2mwYYPlJGF{e2G7 M2ThclEhcA>? NHjuWFZKdmirYnn0bY9vKG:oIFfTWE1nfXOnZDDoeY1idiC{ZXPvcYJqdmGwdDDQTVNM\2GvbXGg[ZhxemW|c3Xk NIL4RXUzOzV2ME[0OS=>
Sf9 NGjSZ4ZMcW6jc3WgRZN{[Xl? Mki3NUBp NV\aXHVvUW6qaXLpeIlwdiCxZjDHV3Qu\nW|ZXSgbJVu[W5icnXjc41jcW6jboSgVGk{U2GucHjhJIV5eHKnc4Pl[C=> NYH0[nlyOjN3NEC2OFU>
SKOV3 MmrLT4lv[XOnIFHzd4F6 MnnkNUDPxE1? NHHnUHMyKGh? NVXmW4JOTE2VTx?= NXv4SpVEUW6qaXLpeIlwdiCxZjDQTVNM[WyyaHGgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbh?= NILxUY4zOzN4MEO0PC=>
MCF7 M4fBemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\vSZMyKM7:TR?= NVjhU2JEQTZiaB?= MVfEUXNQ MoPBS2k2OD1yLkC3NFIh|ryP MYSyN|M3ODN2OB?=
SKOV3 NXTWPGdkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUSxJO69VQ>? MkCxPVYhcA>? MX\EUXNQ NXnPVJp6T0l3ME2wMlE1PzZizszN M{P2RVI{OzZyM{S4
PC3 NV;ZO|RKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUS3NkBp MUXEUXNQ NWDp[IhlUUN3ME2wMlI5KM7:TR?= NI\l[2czOTl6MUexOC=>
MCF7.1 NYnicYlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVK3NkBp MmTCSG1UVw>? Mlj0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3MlEh[2WubIOg[ZhxemW|c3nu[{BJTVJ{IHflcoUhf2m2aDDJR|UxKG:oIECuNlgh|ryP NHjvW2kzOTl6MUexOC=>
MCF7-neo/Her2 MliyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX24e4ZbPzJiaB?= NYDxZ|dTTE2VTx?= MlXDTWM2OD1yLkK5JO69VQ>? MXiyN|Y3OjlyMx?=
MCF7-neo/Her2 MnjnT4lv[XOnIFHzd4F6 M3:2dGlvcGmkaYTpc44hd2ZiUFmzT4FteGijIHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iCDS2SgdIhwe3Cqb4L5cIF1cW:wIHH0JHM1PzNid3n0bEBKSzVyIH;mJFAvODB5IN88US=> M33Ge|I{PjZ{OUCz
PC3 NF\jPIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LmN|czKGh? NYfMNZE2TE2VTx?= NUPrclR7TUN3ME2wMlM1KM7:TR?= NUnDWpJHOjF7OEW2N|k>
MCF7.1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX23NkBp MXvEUXNQ NWLsOYdzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4NjFiY3XscJMh\XiycnXzd4lv\yCSSUPLZYxxcGFibYX0ZY51KHerdHigSWM2OCCxZjCwMlM6KM7:TR?= NGXPN4MzOTl6NU[zPS=>
PC3 Mm[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVq3NkBp NXzhTZRTTE2VTx?= NVq3SJJMSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOg[IVncWOrZX70JIlvKFCWRV6ge4l1cCCLQ{WwJI9nKDBwM{mg{txO M1[3SlIxODVyNk[5
MCF7.1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjnO|IhcA>? MlXSSG1UVw>? MlXpRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3MlEh[2WubIOg[ZhxemW|c3nu[{BRUTONYXzwbIEhdXW2YX70JJdqfGhiSVO1NEBw\iByLkO0JO69VQ>? M3XKb|IxODVyNk[5
MCF7.1 NWrIUZo3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVOyRYd5PzJiaB?= MofXSWM2OD1yLkeyJO69VQ>? MXiyNFM1PjZ3Nh?=
NCI-H1975 M{PNUmN6fG:2b4jpZ{BCe3OjeR?= NYHXbnV5PzJiaB?= MXzJR|UxRTBwMkeg{txO NVjuem1tOjNyNUm1OFU>
H460 M{fLS2N6fG:2b4jpZ{BCe3OjeR?= MkmwO|IhcA>? NXvtSVB5UUN3ME2wMlg4KM7:TR?= M2G3[lI{ODV7NUS1
HT-29 MnLzR5l1d3SxeHnjJGF{e2G7 M1vsbVczKGh? NHLNcoFKSzVyPUCuOlYh|ryP M1;iTVI{ODV7NUS1
HepG2 NGLYVo5EgXSxdH;4bYMhSXO|YYm= MX[3NkBp MUTJR|UxRTFizszN NIDwe3ozOzB3OUW0OS=>
SGC7901 MkjRR5l1d3SxeHnjJGF{e2G7 M4rJRVczKGh? MofTTWM2OD1zLkig{txO M3HjdFI{ODV7NUS1
NCI-H226 NFr5TGFEgXSxdH;4bYMhSXO|YYm= M4rSTlczKGh? NX7o[2dUUUN3ME2yMlkh|ryP NH6zSIYzOzB3OUW0OS=>
A549 NEKzUWpEgXSxdH;4bYMhSXO|YYm= NFLlW2k4OiCq M3;DV2lEPTB;Nj65JO69VQ>? NFfxfVgzOzB3OUW0OS=>
U87MG NWHRZnhMS3m2b4TvfIlkKEG|c3H5 M3rNcVczKGh? NWftZWFvUUN3ME23Mlc4KM7:TR?= M1LUfVI{ODV7NUS1
HBC4 NGDqXnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3sc4dIUTVyPT22MlA{KE1? NVHuVohUOjJ|M{[yOFY>
BSY1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjtcI9oT0l3ME2tOk46OCCP Mo\ZNlI{OzZ{NE[=
HBC5 M4m0XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjXe5VqdG:pR1m1NF0uPi54MDDN Mnn6NlI{OzZ{NE[=
MCF7 NEnKNlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXMcI9oT0l3ME2tO{4{OyCP NX:xV5YxOjJ|M{[yOFY>
MDA-MB-231 NGHMSXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DKZYxw\0eLNUC9MVUvPDZiTR?= NHH0bWEzOjN|NkK0Oi=>
U251 NWTiVVdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfq[ldtd2eJSUWwQU02NjVyIF2= NVu5[G1tOjJ|M{[yOFY>
SF268 NW\2d|ZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfBfIxtd2eJSUWwQU02NjN7IF2= NV:4SoQ{OjJ|M{[yOFY>
SF295 NFHCcY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzEdVlGdG:pR1m1NF0uPi5|NzDN NEDYdFMzOjN|NkK0Oi=>
SF539 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHSVIFtd2eJSUWwQU03NjVyIF2= NFLZUoszOjN|NkK0Oi=>
SNB75 NFLORYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXNcI9oT0l3ME2tO{4yOCCP NHy4OoMzOjN|NkK0Oi=>
SNB78 NHLqOYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHPb45td2eJSUWwQU03NjV{IF2= MkDhNlI{OzZ{NE[=
HCC2998 NXrMTJo3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XEVYxw\0eLNUC9MVYvOjliTR?= MVuyNlM{PjJ2Nh?=
KM12 M2rDTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nHWYxw\0eLNUC9MVUvPzZiTR?= MViyNlM{PjJ2Nh?=
HT-29 MkfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTWcI9oT0l3ME2tOk4{OCCP MnH5NlI{OzZ{NE[=
HCT15 NYPvc4lET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\sTWk1dG:pR1m1NF0uPi5zMjDN MWiyNlM{PjJ2Nh?=
HCT116 MmHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnHPXRtd2eJSUWwQU02Njh5IF2= NFG2coYzOjN|NkK0Oi=>
NCI-H23 MkSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLsc4dIUTVyPT21Mlc{KE1? M{XmZVIzOzN4MkS2
NCI-H226 NYiwOphUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXX[GRzdG:pR1m1NF0uPi5{MTDN MV2yNlM{PjJ2Nh?=
NCI-H522 MmroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1z2dYxw\0eLNUC9MVYvPThiTR?= M1qzUFIzOzN4MkS2
NCI-H483 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjENJBtd2eJSUWwQU03NjV4IF2= MVeyNlM{PjJ2Nh?=
A549 MkDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFruPW1td2eJSUWwQU03NjF3IF2= MXyyNlM{PjJ2Nh?=
DMS273 M1XaNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;sc4dIUTVyPT22MlQ{KE1? MlH2NlI{OzZ{NE[=
DMS114 NY\OcZA1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M325fIxw\0eLNUC9MVUvQTJiTR?= MWCyNlM{PjJ2Nh?=
LOXIMVI M1Pncmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDxVWJ4dG:pR1m1NF0uPi5{OTDN MoXYNlI{OzZ{NE[=
OVCAR3 MmXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{THcoxw\0eLNUC9MVYvPzFiTR?= NGHHTokzOjN|NkK0Oi=>
OVCAR4 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTsc4dIUTVyPT21Mlc3KE1? M3ixPVIzOzN4MkS2
OVCAR5 NWrhVW9yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1v6Xoxw\0eLNUC9MVYvOjZiTR?= MVWyNlM{PjJ2Nh?=
OVCAR8 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDRcI9oT0l3ME2tOU44OyCP NEHJNWkzOjN|NkK0Oi=>
SKOV3 NELmR3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGj0XGttd2eJSUWwQU03NjV{IF2= NHqwV2QzOjN|NkK0Oi=>
RXF631L MmW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXsc4dIUTVyPT22Mlg5KE1? MVeyNlM{PjJ2Nh?=
ACHN NI\JVnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYmxdZl7dG:pR1m1NF0uPi5yNzDN NFvtbFMzOjN|NkK0Oi=>
St-4 NYDQfWU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TXW4xw\0eLNUC9MVUvPTZiTR?= MVGyNlM{PjJ2Nh?=
MKN1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3xPJRtd2eJSUWwQU04NjB6IF2= NH[1XVAzOjN|NkK0Oi=>
MKN7 NUn4XVlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HB[oxw\0eLNUC9MVYvPTBiTR?= NFHRTo8zOjN|NkK0Oi=>
MKN28 M2nDfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvPcJVtd2eJSUWwQU02NjV{IF2= M1zMclIzOzN4MkS2
MKN45 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHsc4dIUTVyPT22MlU2KE1? NEnISpIzOjN|NkK0Oi=>
MKN74 NYHmUIFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DSRoxw\0eLNUC9MVYvODJiTR?= NXq2THNnOjJ|M{[yOFY>
DU145 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrZd5htd2eJSUWwQU02Njh3IF2= M1PkSVIzOzN4MkS2
PC3 M3zidmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HBb4xw\0eLNUC9MVYvPjZiTR?= NXjS[GdoOjJ|M{[yOFY>
ES5 M1P1Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrHRXBKSzVyPUWwMlIyKG6P NFfXPFNUSU6JRWK=
HH MmD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTFzMT6wPEBvVQ>? M2fMN3NCVkeHUh?=
MHH-PREB-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33Zc2lEPTB;MUG0MlMhdk1? NYH5V5J7W0GQR1XS
NCI-H1770 M4nCOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWC4ZoE3UUN3ME2xNlMvQDZibl2= M{HrdHNCVkeHUh?=
HuO9 NXjwXI5kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\LNW5KSzVyPUKwOk4xOiCwTR?= MorTV2FPT0WU
HAL-01 NIrHU25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXPU5pKSzVyPUKwOk44OyCwTR?= NYjOPI44W0GQR1XS
NOS-1 M33ye2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjFZXVKSzVyPUKxNU45OiCwTR?= NHPDcGZUSU6JRWK=
HGC-27 NX\WTmhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zmWmlEPTB;MkGyMlU4KG6P MnO5V2FPT0WU
NB69 NVL1XWhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGGyVmFKSzVyPUK0OU4zPyCwTR?= NF;sSZJUSU6JRWK=
RS4-11 NELQXnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\qTWM2OD1{NkGuO|Yhdk1? MlvmV2FPT0WU
DOK NH7kSnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TFWWlEPTB;M{CxMlchdk1? NHfTUJRUSU6JRWK=
LB2241-RCC M2PwOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zpWmlEPTB;M{CzMlg1KG6P Ml\uV2FPT0WU
NCI-H1623 M4fjWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYi4d4Y4UUN3ME2zNFQvODhibl2= MkLPV2FPT0WU
YH-13 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTNyND6zNkBvVQ>? NE\5bFRUSU6JRWK=
BPH-1 NVvoTGxOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\BNIRKSzVyPUOxOEBvVQ>? NVTQNlB6W0GQR1XS
AN3-CA NXjDfplsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHSTWM2OD1|NECuN|chdk1? MXzTRW5ITVJ?
ES7 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTN2MT65PUBvVQ>? NUfNRnNzW0GQR1XS
MDA-MB-175-VII Mn3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7FO3F7UUN3ME2zOVIvQTJibl2= MlnuV2FPT0WU
GAMG NUOwXVBET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDhTWM2OD1|N{CuPFUhdk1? NEnmVGRUSU6JRWK=
CHL-1 MnfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTN5OD62OUBvVQ>? M{fwPHNCVkeHUh?=
NB7 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlT6TWM2OD1|OEmuPFMhdk1? NYnPO2FnW0GQR1XS
MFE-280 NVrZd4t{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfiSGlKSzVyPUSxPE4zKG6P NFmyUVBUSU6JRWK=
HL-60 MlXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTR{NT63OUBvVQ>? MoLEV2FPT0WU
GCIY NXq2VINjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHWTWM2OD12M{OuPEBvVQ>? MXXTRW5ITVJ?
MDA-MB-361 M3jQ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjBU49EUUN3ME20N|kvOTNibl2= NIr6VIZUSU6JRWK=
LXF-289 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mme1TWM2OD12NEiuNlchdk1? NG[5TpRUSU6JRWK=
NBsusSR M{DLSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfGVlVkUUN3ME20PFgvQDVibl2= NIP4R45USU6JRWK=
KU-19-19 MknsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nkXmlEPTB;NUG2MlA4KG6P M2\aenNCVkeHUh?=
A204 NVL6NIxZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HhWGlEPTB;NUKyMlM{KG6P MnzNV2FPT0WU
LB1047-RCC MmnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHLRpBKSzVyPUWyNk46OyCwTR?= MUjTRW5ITVJ?
COLO-684 NX\DWIFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTV{Mz6xNUBvVQ>? MV7TRW5ITVJ?
PA-1 MkHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrkeVF6UUN3ME21N|IvPDFibl2= MVrTRW5ITVJ?
MG-63 NV3uSVdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHQPGZKUUN3ME21OFEvOTFibl2= MlHuV2FPT0WU
BHT-101 MlHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnJTWM2OD13NESuPVQhdk1? MYDTRW5ITVJ?
NKM-1 NH70UHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjsUGpOUUN3ME21PVMvODlibl2= NILS[llUSU6JRWK=
T47D NWKyR3o2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfNU|gxUUN3ME21PVcvPTZibl2= MmnJV2FPT0WU
MOLT-4 NIXmR|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTZ{Mz62NkBvVQ>? NVz3c2hyW0GQR1XS
IGROV-1 M{jqPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTZ|ND6zNUBvVQ>? NHT5clRUSU6JRWK=
ES4 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7WW5Q3UUN3ME22N|kvPTRibl2= M4\xSnNCVkeHUh?=
HuO-3N1 NVjw[5hGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWCy[GFsUUN3ME22OFIvOzhibl2= MoDmV2FPT0WU
NEC8 NYqye2xOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjzfG9kUUN3ME22OVMvPTdibl2= MkPrV2FPT0WU
HO-1-N-1 NHq1SFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTZ3OT6xO{BvVQ>? NFG1cllUSU6JRWK=
EPCL-272H Mn\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\yZWxzUUN3ME22PFcvOjFibl2= M1L2[3NCVkeHUh?=
D-263MG MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jZe2lEPTB;N{G4MlEhdk1? NUDtfZB[W0GQR1XS
MV-4-11 Ml;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEX0bZhKSzVyPUeyOE4{OSCwTR?= MoXCV2FPT0WU
SK-NEP-1 MnHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTd{NT65OEBvVQ>? M{PrbXNCVkeHUh?=
SW872 M3nWNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYq4OplRUUN3ME23NlcvQDlibl2= MVzTRW5ITVJ?
P30-OHK NWi3VmtNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1[wO2lEPTB;N{OwMlcyKG6P NWD1V5drW0GQR1XS
OMC-1 M3fFTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HYNmlEPTB;N{WxMlA6KG6P NGThXJJUSU6JRWK=
LoVo M2LvV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;mTWM2OD15N{euPUBvVQ>? M2q0O3NCVkeHUh?=
LNCaP-Clone-FGC MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXkPHJKSzVyPUe5Ok4{PCCwTR?= MVzTRW5ITVJ?
L-363 NGLvV2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTd7OD60NkBvVQ>? NUTPO|dSW0GQR1XS
ES8 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRThzMD61NkBvVQ>? NVmyRXRXW0GQR1XS
697 M{K3[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLiTWM2OD16M{GuOVUhdk1? MlfEV2FPT0WU
HSC-3 M3T5cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7GcZJKSzVyPUizPU42PCCwTR?= M1e5W3NCVkeHUh?=
H4 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTh3MD64OUBvVQ>? MVXTRW5ITVJ?
QIMR-WIL NXn6S2M6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nlemlEPTB;OE[1MlIhdk1? NYnmZ4dNW0GQR1XS
OAW-42 Mn3DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PwPGlEPTB;OEeyMlE6KG6P NWf6eFQ2W0GQR1XS
MCF7 NWPpfFhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTh7OD61PUBvVQ>? M1\MdXNCVkeHUh?=
SCC-25 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPsTWM2OD17MUSuNVkhdk1? M4TqXnNCVkeHUh?=
NCI-H1563 MkTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfOXFhUUUN3ME25NVUvQTlibl2= NE\3PJlUSU6JRWK=
OVCAR-5 M{ja[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTl2MD6xO{BvVQ>? NY\3RpBrW0GQR1XS
HDLM-2 MoHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTl2OT6yJI5O MmPLV2FPT0WU
NB5 NIm2SXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrtR3ZkUUN3ME25OVYvPiCwTR?= NWPoSpZvW0GQR1XS
NCI-H292 MoLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTl5ND6zNkBvVQ>? NEDUUpJUSU6JRWK=
A101D M1\ofmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofHTWM2OD17OUCuNVkhdk1? M1LLfHNCVkeHUh?=
NCI-H1648 NW[1UFZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGe4PY1KSzVyPUm5PE42OSCwTR?= NIW0cXBUSU6JRWK=
EKVX NXrTc4E3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELJOHpKSzVyPUGuNFEzQSEQvF2= MWnTRW5ITVJ?
SW1710 M2TiSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXexSmhwUUN3ME2xMlA1OjN|IN88US=> Mm\0V2FPT0WU
WM-115 MoqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTFwME[2OVYh|ryP MlTtV2FPT0WU
CAL-54 M334dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTYTWM2OD1zLkC3NFgyKM7:TR?= MnW1V2FPT0WU
TGBC24TKB NYXQNItVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnH3TWM2OD1zLkC4NFQ2KM7:TR?= MmnLV2FPT0WU
NCI-H520 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfKSXdiUUN3ME2xMlA5QTZ5IN88US=> NV\mWIdNW0GQR1XS
D-423MG NX63Sm1RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nlOWlEPTB;MT6wPVk3OiEQvF2= M2j3RXNCVkeHUh?=
BFTC-905 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTFwMUO0OFkh|ryP NV[0ZmhYW0GQR1XS
HT Mlf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nVT2lEPTB;MT6xN|Q4QCEQvF2= M1TWenNCVkeHUh?=
CTB-1 NYrJZ2l6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;xVm5KSzVyPUGuNVQzQTNizszN NVHteZVEW0GQR1XS
Hs-578-T MkXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\pTWM2OD1zLkG5OVY2KM7:TR?= NUG2[ZQ1W0GQR1XS
HuH-7 M2LOcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfSTWM2OD1zLkKwPVQ6KM7:TR?= NFPlTYdUSU6JRWK=
LB996-RCC NULXclhyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTFwMkKxO|ch|ryP NXTkOVlpW0GQR1XS
KYSE-270 MlXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3u4e2lEPTB;MT6yPVc{PCEQvF2= MmLwV2FPT0WU
A4-Fuk M1KyWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjCTVBKSzVyPUGuNlk6QTNizszN NIHqdY9USU6JRWK=
A498 M1HvXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HTXWlEPTB;MT6zNFQ4PCEQvF2= NUPBVlhNW0GQR1XS
SK-MEL-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2e1fGlEPTB;MT6zNFY4QSEQvF2= MkLtV2FPT0WU
AU565 NFj0[otIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnNb4RKSzVyPUGuN|E5PjNizszN NHXZR5VUSU6JRWK=
Saos-2 NGGyZ5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\TbGlEPTB;MT6zN|IxPSEQvF2= M2O4dHNCVkeHUh?=
A549 MlHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLBS|RKSzVyPUGuN|k6PyEQvF2= M2qzfXNCVkeHUh?=
BFTC-909 NIrnUllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTaS2FVUUN3ME2xMlQ{OzB3IN88US=> NVvUbGFQW0GQR1XS
MDA-MB-415 NUm0d5RGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTFwNEi2PVIh|ryP M2LHfHNCVkeHUh?=
639-V MoPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTFwNUCyOFUh|ryP NV:xPI02W0GQR1XS
A704 MkD6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TGXWlEPTB;MT61NFc5PSEQvF2= MnfOV2FPT0WU
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SF268 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnGe5U1UUN3ME2xOk41PTJizszN MUXTRW5ITVJ?
OE19 NEG5UYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XTN2lEPTB;MU[uOVI1KM7:TR?= NIHiO3RUSU6JRWK=
MLMA NGXjNoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTF4LkW1O|Eh|ryP NH3kSnVUSU6JRWK=
MDA-MB-231 M1v6cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4i5Z2lEPTB;MU[uO|E{PiEQvF2= NEfzfpZUSU6JRWK=
TGW M3TWbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3uVJJPUUN3ME2xOk45OTB{IN88US=> NXXXZWFVW0GQR1XS
MDA-MB-453 NWTFfYU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTF5LkCwNFMh|ryP NUjjfJVXW0GQR1XS
SNU-C2B Ml7BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUO2SVM6UUN3ME2xO{4xOjN5IN88US=> NYG2bmpsW0GQR1XS
A427 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTVTWM2OD1zNz6yN|M1KM7:TR?= NIfPRVFUSU6JRWK=
SK-MEL-2 NHnZOldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTF5LkOyNVMh|ryP M4Di[HNCVkeHUh?=
KURAMOCHI M{LtcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvOdlFKSzVyPUG3MlM5QTdizszN MWjTRW5ITVJ?
IST-MEL1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3lTWM2OD1zNz65NVgzKM7:TR?= NEnndoxUSU6JRWK=
NCI-H1793 M2LxeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnkTWM2OD1zOD6xOVgyKM7:TR?= NUPVNmZ1W0GQR1XS
HCC1395 MmCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4[5bGlEPTB;MUiuOVYyOSEQvF2= NF\BXGxUSU6JRWK=
NUGC-3 NH3J[oVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPUU|BKUUN3ME2xPE43PTh2IN88US=> MUnTRW5ITVJ?
BB65-RCC MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIS3fFNKSzVyPUG4MlY3QSEQvF2= M{[2U3NCVkeHUh?=
RMG-I MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTZTWM2OD1zOD63N|gzKM7:TR?= NXLm[5RVW0GQR1XS
LS-513 MmnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jNOGlEPTB;MUiuPVIzQCEQvF2= NHjJRYRUSU6JRWK=
MFM-223 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLLTJdKSzVyPUG5MlA4OTZizszN NFzDbZNUSU6JRWK=
NCI-H727 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkS0TWM2OD1zOT6zNlk2KM7:TR?= MWTTRW5ITVJ?
KP-4 MmTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDBbpJKSzVyPUG5Mlg2OzFizszN NXnFTY0{W0GQR1XS
NB13 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHOeXZKSzVyPUG5Mlg5OzlizszN NYLpS4E4W0GQR1XS
UACC-893 NVTld254T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTwb2pnUUN3ME2xPU46PzV5IN88US=> M1rJVXNCVkeHUh?=
HT-1197 NXzNWnpOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEf2eWJKSzVyPUKwMlI6PThizszN NV7hZpQyW0GQR1XS
NCI-H2029 NFnVOGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHWy[29KSzVyPUKwMlMzPjZizszN NU\LeZF6W0GQR1XS
GI-ME-N M2XqTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEj0dnNKSzVyPUKwMlM{PzNizszN NHTOTVhUSU6JRWK=
OVCAR-3 M{fmZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTJyLkW4NlIh|ryP NYjTfXVsW0GQR1XS
HD-MY-Z MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTJzLkO2PVYh|ryP Ml62V2FPT0WU
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SCH NFjWcXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTJ{LkS5OkDPxE1? Mk\2V2FPT0WU
KARPAS-299 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTJ|LkO4PFch|ryP NHzmTo5USU6JRWK=
NCI-H1650 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTJ|LkmyOFEh|ryP NWnSPVdsW0GQR1XS
ACHN NYDDd2F4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTlTWM2OD1{ND60OlU3KM7:TR?= NF\ucZRUSU6JRWK=
M059J NXThWGRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3qydGlEPTB;MkSuOVY{PCEQvF2= M2T4XnNCVkeHUh?=
AM-38 MnW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXubFNpUUN3ME2yOU41QDFizszN MnzXV2FPT0WU
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COLO-824 M2ThT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jYS2lEPTB;MkWuOVU6QSEQvF2= NI[xWI5USU6JRWK=
NCI-H1155 NYHEfFdkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3rTWM2OD1{NT61PFQ4KM7:TR?= Ml7MV2FPT0WU
NCI-H441 NHLvSlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rhV2lEPTB;MkWuO|Q3PSEQvF2= M1u3[nNCVkeHUh?=
J-RT3-T3-5 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTJ4LkOwNlch|ryP NIHxZm5USU6JRWK=
JEG-3 NYnCToVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFS1N4FKSzVyPUK2MlY5ODVizszN NXjEPYR4W0GQR1XS
RKO MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrLTWM2OD1{Nj63OlMzKM7:TR?= NV;QWXFWW0GQR1XS
CAL-85-1 NI\CNFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPRZpc3UUN3ME2yO{4zOTF6IN88US=> M4npbnNCVkeHUh?=
CAL-120 NWfRVXZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELDXIxKSzVyPUK3MlY6OTRizszN Mm\oV2FPT0WU
NCI-H2452 NHzt[XBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvQbYd1UUN3ME2yO{44PzF4IN88US=> M1XDPHNCVkeHUh?=
NCI-H1395 NFnpPFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXm3XHFOUUN3ME2yO{44QDN|IN88US=> MYXTRW5ITVJ?
KYSE-450 MmLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\VTWM2OD1{Nz65PFYzKM7:TR?= M2TpWXNCVkeHUh?=
S-117 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jhZWlEPTB;MkmuN|g2PyEQvF2= NVHncWd7W0GQR1XS
SW13 M1\EcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH75WHNKSzVyPUK5Mlg2OTlizszN MVPTRW5ITVJ?
ES3 MonFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIOy[3pKSzVyPUOwMlM4OzNizszN MkDWV2FPT0WU
HCT-116 Mom4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTUTWM2OD1|MD61OVU1KM7:TR?= M33PUHNCVkeHUh?=
NCI-H1693 NWHmZmlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nqUmlEPTB;M{CuOVk1OiEQvF2= Mo\BV2FPT0WU
VM-CUB-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HGTWlEPTB;M{CuOlQyOyEQvF2= NVTvcIRvW0GQR1XS
NCI-H2170 MmTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PVO2lEPTB;M{GuOVc5PCEQvF2= NFvmSIpUSU6JRWK=
ALL-PO M1TyR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPFTWM2OD1|MT64OFI5KM7:TR?= MVrTRW5ITVJ?
NCI-H661 M3TVR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTXTWM2OD1|Mj6wOlI{KM7:TR?= NVHvfINsW0GQR1XS
NCI-H2347 MlzIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDVTWM2OD1|Mj60PFM4KM7:TR?= M4nSVXNCVkeHUh?=
FTC-133 M1TpbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{K2eGlEPTB;M{KuO|A3KM7:TR?= NV7wbms4W0GQR1XS
COLO-829 M{D0VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nsZ2lEPTB;M{OuN|Q3PyEQvF2= MkXPV2FPT0WU
GOTO MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTtR4JKSzVyPUOzMlUzPThizszN MoiyV2FPT0WU
YAPC MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PUbmlEPTB;M{OuPFE2QSEQvF2= NHvtc5lUSU6JRWK=
LCLC-103H NYq5PXh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3FTWM2OD1|ND6xOlI1KM7:TR?= Mlm0V2FPT0WU
SiHa MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTN2LkO4NVch|ryP M3[yTXNCVkeHUh?=
LK-2 MmftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHz4dYJKSzVyPUO0MlU4ODhizszN MoXBV2FPT0WU
KP-N-YS NYK1NoUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17MdGlEPTB;M{SuO|IxOiEQvF2= MkLUV2FPT0WU
NCI-SNU-1 Ml\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTN3LkG3PUDPxE1? NX30c5VPW0GQR1XS
KNS-81-FD MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUn3Xow2UUN3ME2zOU43PjNizszN MYDTRW5ITVJ?
SCC-9 NY\me4RQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoKxTWM2OD1|Nj63NVQ3KM7:TR?= M4jrOHNCVkeHUh?=
SH-4 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH76NVdKSzVyPUO2Mlc{KM7:TR?= MWjTRW5ITVJ?
HCC-1954 NGf5VHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvMUpY2UUN3ME2zO{4zPzJ7IN88US=> NUHpeVJiW0GQR1XS
BALL-1 M3:2W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTN5LkWzNVYh|ryP M2jlb3NCVkeHUh?=
BE-13 M2H3TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDYO|JiUUN3ME2zO{44ODF6IN88US=> NID0NoxUSU6JRWK=
COLO-678 NGrqPWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLIVW9KSzVyPUO3Mlk1OzdizszN MWXTRW5ITVJ?
SK-MEL-3 NFT4eo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVe3fXo{UUN3ME2zPE4zOzl5IN88US=> NXXob|VxW0GQR1XS
OAW-28 MlvFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTN6Lk[zPUDPxE1? NEj1co1USU6JRWK=
CAMA-1 NIHqfZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\UTWM2OD1|OD65OlkyKM7:TR?= MVzTRW5ITVJ?
C2BBe1 NHvNR3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknKTWM2OD1|OT64NVgh|ryP Mn[yV2FPT0WU
A3-KAW MojPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{frZmlEPTB;NECuN|Y3OSEQvF2= NEHFNZpUSU6JRWK=
SK-MEL-24 NHK1WGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzFPWlKSzVyPUSwMlU6OzFizszN NXO1S2VNW0GQR1XS
KYSE-140 MkTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVz5T|JzUUN3ME20NE44OTZ3IN88US=> M4jvOXNCVkeHUh?=
MOLT-16 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zQTWlEPTB;NEGuNVU{PiEQvF2= MmG0V2FPT0WU
CFPAC-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTR{LkWyNVEh|ryP M2TyVnNCVkeHUh?=
NB14 M{W3eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTR{LkewNlch|ryP Mof3V2FPT0WU
COLO-792 M2HGe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnK1TWM2OD12Mj64PVYyKM7:TR?= MnfEV2FPT0WU
RH-1 NVewXmpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LLRmlEPTB;NEOuOFg{PiEQvF2= NXryO4tQW0GQR1XS
NCI-H522 MofDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIT0cmVKSzVyPUS0MlM2PjhizszN MWDTRW5ITVJ?
Ca-Ski MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX65ZWxwUUN3ME20OE45OTF2IN88US=> MkTTV2FPT0WU
KGN M2S0TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTR6LkOwOlMh|ryP NH;M[mFUSU6JRWK=
UACC-62 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3iTWM2OD12OD60NFczKM7:TR?= M1\u[nNCVkeHUh?=
NCI-H358 M37ONGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTR7LkOwNVgh|ryP MVLTRW5ITVJ?
LS-411N MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\zb2lEPTB;NEmuN|EyQCEQvF2= MULTRW5ITVJ?
IST-MES1 NUfQfZNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;VOmlEPTB;NEmuOVYzPSEQvF2= NXnBZYptW0GQR1XS

多くの細胞株試験データを見る場合、クリックしてください

体内試験 GDC-0941 shows limited microsomal metabolism, resulting in 78% oral bioavailability [5]. Administration of GDC-0941 at 75 mg/kg/day displays significant inhibitory effect against established human U87MG glioblastoma xenografts in female NCr athymic mice, with tumor growth inhibition of 83%. [1] Oral administration of GDC-0941 at 150 mg/kg/day inhibits the growth of HER2-amplified, trastuzumab-resistant MDA-MB-361.1 xenografts in mice, and significantly delays the tumor progression, in association with potent induced apoptosis in tumors. [2] GDC-0941 (75 mg/kg/day) treatment for 2 weeks induces ~40% reduction in tumor volume of spontaneous B-cell follicular lymphomas developed in PTEN+/-LKB1+/hypo mice, accompanied by ablation of phosphorylation of Akt, S6K and SGK (serum and glucocorticoid protein kinase) protein kinases. [4]

お薦めの試験操作(参考用のみ)

キナーゼ試験:

[1]

+ 展開

Scintillation proximity assay:

Recombinant human PI3Kα, PI3Kβ, and PI3Kδ are coexpressed in a Sf9 baculovirus system with the p85α regulatory subunit and purified as GST-fusion proteins using affinity chromatography on glutathione-sepharose. Recombinant human PI3Kγ is expressed as monomeric GST-fusions and purified similarly. GDC-0941 is dissolved in DMSO and added to 20 mM Tris-HCl (pH 7.5) containing 200 μg yttrium silicate (Ysi) polylysine SPA beads, 4 mM MgCl2, 1 mM dithiothreitol (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, and 4% (v/v) DMSO in a total volume of 50 μL. The recombinant GST-fusion of PI3Kα (5 ng), PI3Kβ (5 ng), PI3Kδ (5 ng), or PI3Kγ (5 ng) is added to the assay mixture to initiate the kinase reaction. After incubation for 1 hour at room temperature, the kinase reaction is terminated with 150 μL PBS. The mixture is then centrifuged for 2 minutes at 2000 rpm and read using a Wallac Microbeta counter. The reported IC50 values are calculated using a sigmoidal, dose-response curve fit in MDL Assay Explorer.
細胞試験:

[2]

+ 展開
  • 細胞株: SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, and MKN-7 cells
  • 濃度: Dissolved in DMSO, final concentrations ~10 μM
  • 反応時間: 48 and 72 hours
  • 実験の流れ:

    Cells are exposed to various concentrations of GDC-0941 for 48, and 72 hours. Proliferation/viability of cells is detected by using the CellTiter-Glo Luminescent Cell Viability Assay. The pAkt (Ser473), cleaved caspase-3, and cleaved PARP are analyzed by western blot. The Caspase-Glo 3/7 assay and the Cell Death Detection ELISAplus assay are used to detect caspase 3/7 activity, and apoptosis, respectively.


    (参考用のみ)
動物試験:

[2]

+ 展開
  • 動物モデル: NCR nude mice implanted with MDA-MB-361.1 cells, and SCID, C.B-17/IcrHsd-Prkdcscid mice implanted subcutaneously with BT474-M1 cells
  • 製剤: Dissolved in 10% DMSO, 5% Tween 20, 85% water
  • 投薬量: ~150 mg/kg/day
  • 投与方法: Oral gavage
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 44 mg/mL (85.66 mM)
Water Insoluble
Ethanol Insoluble
体内 順序で溶剤を入れること:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
5mg/mL

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 513.64
化学式

C23H27N7O3S2

CAS No. 957054-30-7
保管
別名 RG7321

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00999128 Completed Healthy Volunteers Genentech, Inc. October 26, 2009 Phase 1
NCT02092831 Completed Healthy Volunteer Genentech, Inc. April 2014 Phase 1
NCT01740336 Active, not recruiting Breast Cancer Genentech, Inc. February 2013 Phase 2
NCT01493843 Completed Non-Squamous Non-Small Cell Lung Cancer Genentech, Inc. January 2012 Phase 2
NCT01474668 Completed Healthy Volunteer Genentech, Inc. October 2011 Phase 1
NCT01437566 Completed Breast Cancer Genentech, Inc. October 2011 Phase 2

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PI3K信号経路図

PI3K Inhibitors with Unique Features

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