エストロゲン/プロゲストゲン受容体

信号経路図

研究分野

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1191 Fulvestrant <1 mg/mL 100 mg/mL 100 mg/mL
S1972 Tamoxifen Citrate <1 mg/mL 100 mg/mL 100 mg/mL
S1227 Raloxifene HCl <1 mg/mL 100 mg/mL <1 mg/mL
S1709 Estradiol <1 mg/mL 54 mg/mL 5 mg/mL
S2606 Mifepristone <1 mg/mL 85 mg/mL 19 mg/mL
S8372 AZD9496 <1 mg/mL 88 mg/mL 88 mg/mL
S4673 Etonogestrel <1 mg/mL 64 mg/mL 64 mg/mL
S1776 Toremifene Citrate <1 mg/mL 100 mg/mL <1 mg/mL
S1251 Dienogest <1 mg/mL 62 mg/mL <1 mg/mL
S2128 Bazedoxifene HCl <1 mg/mL 101 mg/mL <1 mg/mL
S2604 Dehydroepiandrosterone (DHEA) <1 mg/mL 57 mg/mL 57 mg/mL
S1376 Gestodene <1 mg/mL 62 mg/mL 8 mg/mL
S2561 Clomifene citrate <1 mg/mL 120 mg/mL 11 mg/mL
S2450 Equol <1 mg/mL 48 mg/mL 48 mg/mL
S1727 Levonorgestrel <1 mg/mL 45 mg/mL 2 mg/mL
S2567 Medroxyprogesterone acetate <1 mg/mL 12 mg/mL 12 mg/mL
S2473 Hexestrol <1 mg/mL 42 mg/mL 42 mg/mL
S1377 Drospirenone <1 mg/mL 73 mg/mL 11 mg/mL
S1705 Progesterone <1 mg/mL 22 mg/mL 63 mg/mL
S1304 Megestrol Acetate <1 mg/mL 33 mg/mL 15 mg/mL
S3081 Ulipristal <1 mg/mL 83 mg/mL 14 mg/mL
S2466 Estriol <1 mg/mL 57 mg/mL 10 mg/mL
S1859 Diethylstilbestrol <1 mg/mL 54 mg/mL 54 mg/mL
S1625 Ethinyl Estradiol <1 mg/mL 59 mg/mL 59 mg/mL
S3149 Estradiol valerate <1 mg/mL 71 mg/mL <1 mg/mL
S1914 Pregnenolone <1 mg/mL 22 mg/mL 22 mg/mL
S1665 Estrone <1 mg/mL 54 mg/mL <1 mg/mL
S2125 Mestranol <1 mg/mL 15 mg/mL 25 mg/mL
S2167 Bazedoxifene Acetate <1 mg/mL 100 mg/mL 25 mg/mL
S4110 Estradiol Benzoate <1 mg/mL 75 mg/mL <1 mg/mL
S3167 Altrenogest <1 mg/mL 62 mg/mL 2 mg/mL
S4629 Chlorotrianisene <1 mg/mL 76 mg/mL <1 mg/mL
S7827 4-Hydroxytamoxifen <1 mg/mL 77 mg/mL <1 mg/mL
S4046 Estradiol Cypionate <1 mg/mL 79 mg/mL 55 mg/mL
S4638 Desogestrel <1 mg/mL 62 mg/mL 62 mg/mL
S2314 Kaempferol <1 mg/mL 57 mg/mL 3 mg/mL
S4674 Hydroxyprogesterone caproate <1 mg/mL 85 mg/mL 85 mg/mL
S4507 17-Hydroxyprogesterone <1 mg/mL 66 mg/mL 66 mg/mL
S7828 Licochalcone A <1 mg/mL 67 mg/mL 67 mg/mL
S1238 Tamoxifen <1 mg/mL 74 mg/mL 74 mg/mL
S7839 Endoxifen HCl <1 mg/mL 74 mg/mL 74 mg/mL
S3160 Ethynodiol diacetate 77 mg/mL 77 mg/mL <1 mg/mL
S4285 Ospemifene <1 mg/mL 75 mg/mL 71 mg/mL
S2611 Ethisterone <1 mg/mL 0.05 mg/mL <1 mg/mL

亜型選択性的な製品

製品コード 製品説明 文献中の使用例 お客様のフィードバック
S8372

AZD9496

S1191

Fulvestrant

Fulvestrant is a Synthetic estrogen receptor antagonist(SERD)

S1972

Tamoxifen Citrate

Tamoxifen Citrateは一種のエストロゲン(estrogen)受容体拮抗剤ですし、エストロゲン結合を競争性的に抑制することを通じて、役立ちます。

S1227

Raloxifene HCl

Raloxifene HCl is estrogen antagonists, inhibits human cytosolic aldehyde oxidase-catalyzed phthalazine oxidation activity with IC50 of 5.7 nM.

S2606

Mifepristone

Mifepristoneは非常に活発な拮抗プロゲステロン受容体と砂糖皮質ホルモン受容体、IC50がそれぞれ 0.2 nM と 2.6 nM になる。

S2466

Estriol

エストリオールは、エストロゲン受容体陰性乳がん細胞の中のGタンパク質結合エストロゲン受容体への敵対者です。

S1238

Tamoxifen

Tamoxifenは一種の胸部組織に作用するエストロゲン受容体の拮抗剤です。

S7839

Endoxifen HCl

Endoxifen HCl, the active metabolite of Tamoxifen, ia a potent and selective estrogen receptor antagonist. Phase 2.

S1776

Toremifene Citrate

Toremifene Citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body.

S2128

Bazedoxifene HCl

Entecavir monohydrate (Baraclude) is a reverse transcription, DNA replication and transcription inhibitor with an IC50 of about 0.5 nM.

S2561

Clomifene citrate

Clomifene citrate is a selective estrogen receptor modulator.

S3081

Ulipristal

Ulipristal is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.

S1914

Pregnenolone

Pregnenolone is an endogenous steroid hormone for inhibition of M1 receptor- and M3 receptor-mediated currents with IC50 of 11.4 μM and 6.0 μM, respectively.

S2167

Bazedoxifene Acetate

Bazedoxifene Acetate is a third generation selective estrogen receptor modulator (SERM).

S4629

Chlorotrianisene

S7827

4-Hydroxytamoxifen

S2314

Kaempferol

Kaempferol is a natural flavonol, a type of flavonoid, that has been isolated from plant sources.

S4285

Ospemifene

Ospemifene is a non-hormonal selective estrogen receptor modulator (SERM), used for the treatment of dyspareunia.

S1709

Estradiol

Estradiol is the predominant sex hormone.

S4673

Etonogestrel

S2604

Dehydroepiandrosterone (DHEA)

Dehydroepiandrosterone(DHEA) is a 19-carbon endogenous natural steroid hormone.

S2450

Equol

Equol is an isoflavandiol metabolized from daidzein by bacterial flora in the intestines.

S1727

Levonorgestrel

Levonorgestrel(Levonelle) is a synthetic progestogen used as an active ingredient in some hormonal contraceptives.

S2567

Medroxyprogesterone acetate

Medroxyprogesterone acetate (MPA) is a synthetic progestin and act as a potent progesterone receptor agonist, used to treat abnormal menstruation or irregular vaginal bleeding.

S2473

Hexestrol

Hexestrolは、Erα</b、ERβと結合しまして、 EC50 がそれぞれ 0.07 nM と 0.175 nMです。

S1705

Progesterone

Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.

S1859

Diethylstilbestrol

Diethylstilbestrol, a synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders.

S1625

Ethinyl Estradiol

Ethynyl estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills.

S3149

Estradiol valerate

Estradiol valerate is a synthetic ester used to treat menopausal symptoms and hormone deficiencies.

S2125

Mestranol

Mestranol is the 3-methyl ether of ethinylestradiol. It was the estrogen used in many of the first oral contraceptives.

S4110

Estradiol Benzoate

Estradiol benzoate は、人間のマウスおよび鶏ERαにバインドエストラジオールアナログで、IC50 が22-28 nMです。

S3167

Altrenogest

Altrenogest is a progestogen structurally related to veterinary steroid trenbolone.

S4046

Estradiol Cypionate

Estradiol cypionate 、エストロゲン受容体によりET-1の合成を阻害するエストラジオールの油溶性17β-cyclopentylpropinateエステルである。

S4638

Desogestrel

S4674

Hydroxyprogesterone caproate

S4507

17-Hydroxyprogesterone

S7828

Licochalcone A

Licochalcone A is an estrogenic flavanoid extracted from licorice root, showing antimalarial, anticancer, antibacterial and antiviral activities. Phase 3.

S3160

Ethynodiol diacetate

Ethynodiol diacetate is one of the first synthetic progestogens used in contraceptive pills.

S2611

Ethisterone

Ethisterone is a progestogen hormone being considered to treat prostate cancer.

S1251

Dienogest

Dienogest is an orally active synthetic progesterone (or progestin).

S1376

Gestodene

Gestodene is a progestogen hormonal contraceptive.

S1377

Drospirenone

Drospirenone is a synthetic progestin that is an analog to spironolactone.

S1665

Estrone

Estrone is an estrogenic hormone.

製品コード 製品説明 文献中の使用例 お客様のフィードバック
S8372

AZD9496

製品コード 製品説明 文献中の使用例 お客様のフィードバック
S1191

Fulvestrant

Fulvestrant is a Synthetic estrogen receptor antagonist(SERD)

2015, 6(4):2315-30

2014, 13(1):230-8

2011, 6(7):e21112

S1972

Tamoxifen Citrate

Tamoxifen Citrateは一種のエストロゲン(estrogen)受容体拮抗剤ですし、エストロゲン結合を競争性的に抑制することを通じて、役立ちます。

2014, Timothy E. Richardson

S1227

Raloxifene HCl

Raloxifene HCl is estrogen antagonists, inhibits human cytosolic aldehyde oxidase-catalyzed phthalazine oxidation activity with IC50 of 5.7 nM.

2015, 32(6):577

2014, Health Science Center at Fort Worth

S2606

Mifepristone

Mifepristoneは非常に活発な拮抗プロゲステロン受容体と砂糖皮質ホルモン受容体、IC50がそれぞれ 0.2 nM と 2.6 nM になる。

2014, 24(5):528-40

2014, 9(8):e105528

S2466

Estriol

エストリオールは、エストロゲン受容体陰性乳がん細胞の中のGタンパク質結合エストロゲン受容体への敵対者です。

S1238

Tamoxifen

Tamoxifenは一種の胸部組織に作用するエストロゲン受容体の拮抗剤です。

2015, 6(4):2315-30

2014, Timothy E. Richardson

S7839

Endoxifen HCl

Endoxifen HCl, the active metabolite of Tamoxifen, ia a potent and selective estrogen receptor antagonist. Phase 2.

製品コード 製品説明 文献中の使用例 お客様のフィードバック
S1709

Estradiol

Estradiol is the predominant sex hormone.

S4673

Etonogestrel

S2604

Dehydroepiandrosterone (DHEA)

Dehydroepiandrosterone(DHEA) is a 19-carbon endogenous natural steroid hormone.

S2450

Equol

Equol is an isoflavandiol metabolized from daidzein by bacterial flora in the intestines.

2015, 10.1021/cb5009487

S1727

Levonorgestrel

Levonorgestrel(Levonelle) is a synthetic progestogen used as an active ingredient in some hormonal contraceptives.

S2567

Medroxyprogesterone acetate

Medroxyprogesterone acetate (MPA) is a synthetic progestin and act as a potent progesterone receptor agonist, used to treat abnormal menstruation or irregular vaginal bleeding.

2015, 10.1186/s12990-015-0050-1

S2473

Hexestrol

Hexestrolは、Erα</b、ERβと結合しまして、 EC50 がそれぞれ 0.07 nM と 0.175 nMです。

S1705

Progesterone

Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.

2015, 5(10):3210-20

S1859

Diethylstilbestrol

Diethylstilbestrol, a synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders.

S1625

Ethinyl Estradiol

Ethynyl estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills.

S3149

Estradiol valerate

Estradiol valerate is a synthetic ester used to treat menopausal symptoms and hormone deficiencies.

S2125

Mestranol

Mestranol is the 3-methyl ether of ethinylestradiol. It was the estrogen used in many of the first oral contraceptives.

S4110

Estradiol Benzoate

Estradiol benzoate は、人間のマウスおよび鶏ERαにバインドエストラジオールアナログで、IC50 が22-28 nMです。

S3167

Altrenogest

Altrenogest is a progestogen structurally related to veterinary steroid trenbolone.

S4046

Estradiol Cypionate

Estradiol cypionate 、エストロゲン受容体によりET-1の合成を阻害するエストラジオールの油溶性17β-cyclopentylpropinateエステルである。

S4638

Desogestrel

S4674

Hydroxyprogesterone caproate

S4507

17-Hydroxyprogesterone

S7828

Licochalcone A

Licochalcone A is an estrogenic flavanoid extracted from licorice root, showing antimalarial, anticancer, antibacterial and antiviral activities. Phase 3.

S3160

Ethynodiol diacetate

Ethynodiol diacetate is one of the first synthetic progestogens used in contraceptive pills.

S2611

Ethisterone

Ethisterone is a progestogen hormone being considered to treat prostate cancer.

製品コード 製品説明 文献中の使用例 お客様のフィードバック
S1776

Toremifene Citrate

Toremifene Citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body.

2016, 30(5):393-410

S2128

Bazedoxifene HCl

Entecavir monohydrate (Baraclude) is a reverse transcription, DNA replication and transcription inhibitor with an IC50 of about 0.5 nM.

2014, 57(3):632-41

2014, 57(3):632-41

2016, 24;11(3):e0151182

S2561

Clomifene citrate

Clomifene citrate is a selective estrogen receptor modulator.

S3081

Ulipristal

Ulipristal is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.

S1914

Pregnenolone

Pregnenolone is an endogenous steroid hormone for inhibition of M1 receptor- and M3 receptor-mediated currents with IC50 of 11.4 μM and 6.0 μM, respectively.

S2167

Bazedoxifene Acetate

Bazedoxifene Acetate is a third generation selective estrogen receptor modulator (SERM).

S4629

Chlorotrianisene

S7827

4-Hydroxytamoxifen

2016, 10.1038/onc.2016.379

S2314

Kaempferol

Kaempferol is a natural flavonol, a type of flavonoid, that has been isolated from plant sources.

2016, 68(4):1633-40

2015, 6(8):2824-33

S4285

Ospemifene

Ospemifene is a non-hormonal selective estrogen receptor modulator (SERM), used for the treatment of dyspareunia.

製品コード 製品説明 文献中の使用例 お客様のフィードバック
S1251

Dienogest

Dienogest is an orally active synthetic progesterone (or progestin).

S1376

Gestodene

Gestodene is a progestogen hormonal contraceptive.

S1377

Drospirenone

Drospirenone is a synthetic progestin that is an analog to spironolactone.

S1665

Estrone

Estrone is an estrogenic hormone.