|S1356||Levetiracetam||34 mg/mL||34 mg/mL||34 mg/mL|
|S1813||Amlodipine Besylate||<1 mg/mL||113 mg/mL||14 mg/mL|
|S1293||Cilnidipine||<1 mg/mL||99 mg/mL||15 mg/mL|
|S1811||Amiloride HCl||6 mg/mL||53 mg/mL||5 mg/mL|
|S1425||Ranolazine 2HCl||100 mg/mL||100 mg/mL||<1 mg/mL|
|S3700||DHBP dibromide||100 mg/mL||100 mg/mL||100 mg/mL|
|S8380||YM-58483 (BTP2)||<1 mg/mL||84 mg/mL||84 mg/mL|
|S4202||Verapamil HCl||50 mg/mL||98 mg/mL||12 mg/mL|
|S2482||Manidipine 2HCl||<1 mg/mL||21 mg/mL||<1 mg/mL|
|S1799||Ranolazine||<1 mg/mL||86 mg/mL||20 mg/mL|
|S1662||Isradipine||<1 mg/mL||74 mg/mL||74 mg/mL|
|S1905||Amlodipine||<1 mg/mL||82 mg/mL||82 mg/mL|
|S1885||Felodipine||<1 mg/mL||77 mg/mL||72 mg/mL|
|S2481||Manidipine||<1 mg/mL||122 mg/mL||3 mg/mL|
|S1748||Nisoldipine||<1 mg/mL||77 mg/mL||60 mg/mL|
|S1747||Nimodipine||<1 mg/mL||84 mg/mL||84 mg/mL|
|S2535||Econazole nitrate||<1 mg/mL||89 mg/mL||5 mg/mL|
|S2721||Nilvadipine||<1 mg/mL||77 mg/mL||33 mg/mL|
|S1994||Lacidipine||<1 mg/mL||91 mg/mL||22 mg/mL|
|S2114||Dronedarone HCl||<1 mg/mL||80 mg/mL||40 mg/mL|
|S2446||Levosimendan||<1 mg/mL||56 mg/mL||<1 mg/mL|
|S4181||Nicardipine HCl||<1 mg/mL||100 mg/mL||<1 mg/mL|
|S1808||Nifedipine||<1 mg/mL||69 mg/mL||15 mg/mL|
|S2080||Clevidipine Butyrate||<1 mg/mL||91 mg/mL||3 mg/mL|
|S2017||Benidipine HCl||<1 mg/mL||8 mg/mL||<1 mg/mL|
|S2918||HC-030031||<1 mg/mL||32 mg/mL||<1 mg/mL|
|S2030||Flunarizine 2HCl||<1 mg/mL||5 mg/mL||3 mg/mL|
|S2491||Nitrendipine||<1 mg/mL||72 mg/mL||<1 mg/mL|
|S2050||Strontium Ranelate||<1 mg/mL||<1 mg/mL||<1 mg/mL|
|S3053||Azelnidipine||<1 mg/mL||117 mg/mL||7 mg/mL|
|S2573||Tetracaine HCl||60 mg/mL||60 mg/mL||30 mg/mL|
|S1911||Disodium Cromoglycate||2 mg/mL||<1 mg/mL||<1 mg/mL|
|S1865||Diltiazem HCl||90 mg/mL||90 mg/mL||4 mg/mL|
|S7999||SKF96365||80 mg/mL||80 mg/mL||80 mg/mL|
|S3045||Cinepazide maleate||107 mg/mL||107 mg/mL||<1 mg/mL|
|S8073||Optovin||<1 mg/mL||63 mg/mL||<1 mg/mL|
|S4626||Ethosuximide||28 mg/mL||28 mg/mL||28 mg/mL|
|S4597||Lercanidipine (hydrochloride)||<1 mg/mL||66 mg/mL||1 mg/mL|
|S2403||Tetrandrine||<1 mg/mL||1 mg/mL||2 mg/mL|
|S4084||Lomerizine 2HCl||<1 mg/mL||100 mg/mL||52 mg/mL|
|S4648||Dantrolene sodium hemiheptahydrate||<1 mg/mL||14 mg/mL||<1 mg/mL|
|S7924||Bay K 8644||<1 mg/mL||71 mg/mL||71 mg/mL|
|S2415||Astragaloside A||<1 mg/mL||100 mg/mL||<1 mg/mL|
|S4209||Chlorocresol||<1 mg/mL||29 mg/mL||29 mg/mL|
|S4727||Cinnarizine||<1 mg/mL||73 mg/mL||<1 mg/mL|
- Calcium Channel阻害剤(45)
- 新Calcium Channel製品
Levetiracetam is an antiepileptic compound.
Levetiracetam reduces DNA, synaptic, and neurite damage caused by Dox. (A) An example of cortical cultures pre-treated with 5 μ M Lev and then Dox (0.01 μ M, overnight), fixed and stained with antibodies against MAP2c. Scale bar is 20 μ m. (B) Cortical neurons at 28–32 DIV were pre-treated with 5 μ M Lev, and then a vehicle or with Dox (0.01 μ M for 3 days, or 0.1 μ M, overnight) was added. Neurons were fixed, and stained for MAP2c, synapsin, and with the Hoechst dye, and imaged. Note that red MAP2c staining also includes Dox's red fluorescence. (C) Synaptically developed primary cortical cultures at 28−32 DIV were pretreated with 5 mM Lev, and then a vehicle or with Dox (0.01 μM for 3 days, or 0.1 μM, overnight) was added. Neurons were then fixed, and stained with antibodies against γH2A.X and MAP2c, and with the Hoechst dye. Blue staining was used by the algorithm to identify and analyze γH2A.X.
Amlodipine Besylate is a long-acting calcium channel blocker with an IC50 of 1.9 nM.
Cilnidipine is a calcium channel blocker.
Amiloride hydrochloride(Midamor), a pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells.
Ranolazine 2HCl, is an antianginal medication.
f, Cells were pretreated with or without 5 μM verapamil and then treated with the indicated concentrations of 17-DMAG for 6 h. The proteins involved in ALK-related signaling were detected by western blot analysis.
Manidipine 2HCl は、Ca2+現在 に賛成のカルシウムチャネル・ブロッカーであるManidipineのHCl塩の形で、IC50 が2.6 nMです。
Ranolazine(Ranexa) is an antianginal medication.
Isradipine is a calcium channel blocker with an IC50 of 34±8 μM.
Amlodipine is a long-acting calcium channel blocker with an IC50 of 1.9 nM.
Felodipine は＜がすする選択的なL-タイプCaが、＞2+＜で/すする> チャンネル・ブロッカー、IC50 が0.15 nMになる。
Manidipine is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM.
Nisoldipine (Sular)は特定L型CaV1.2カルシウムチャネル遮断剤、 IC50 が 10 nMになる.
Nimodipineは一種のジヒドロピリジン カルシウム チャネル（ dihydropyridine calcium channel）阻害剤で、一種の自食阻害剤ですが、高血圧の治療に使用されます。
Assessment of the role of Ca2+ channels during RSV replication. HEp-2 cells were infected with RSV strain long at an MOI of 0.1, and treated with calcium channel blockers nifedipine, nimodipine, and tetrandrine (A), at indicated concentrations. Supernatants were collected at 48 h postinfection and viral titers were determined by immunoplaque assay. Grey bars represent cytotoxicity of the compounds. The data presented were obtained from two independent experiments. Error bars represent the standard deviations from two independent experiments. NS, no differences at a significance level of 0.05.
Econazole nitrate (Spectazole) is an imidazole class antifungal medication.
Nilvadipine is a potent calcium channel blocker with an IC50 of 0.03 nM.
Lacidipine is a L-type calcium channel blocker.
Dronedarone HCl is a therapy for the treatment of patients with paroxysmal and persistent atrial fibrillation or atrial flutter.
Results of hit validation experiments for these four compounds for animals treated at L1 stage at four different concentrations (0.5, 5, 25, and 50 μM). The blue bars represent the values obtained from the original screen as reference points. Error bars are standard error of the mean. Statistical significance for all different doses for individual compounds was calculated with respect to the lowest concentration using two-tailed, t-test (nZ70 animals except n = 37 for Geld 25 μM). The statistical significance values are represented as P<0.05 (*) and P<0.005 (**).
Levosimendan is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC).
(B-E) The % of GFP-positive cells upon compound treatment were determined for the indicated HIV-1 latency cell lines (B. J-LAT 6.3; C. JLAT 10.6; D. CA5; E. EF7). Results were normalized to DMSO control. Values represent the mean ± s.d. (n = 4-6). * p < 0.05, one-way ANOVA followed by Tukey’s multiplecomparison test
Nifedipine(Adalat), a potent vasodilator agent with calcium antagonistic action.
The fold change of C-peptide content after octreotide, nicorandil and nifedipine treatment. Octreotide, nicorandil and nifedipine decreased insulin secretion in wild-type, heterozygous mutated and homozygous mutated cells.
Clevidipine Butyrate is a dihydropyridine calcium channel blocker use as agent for the reduction of blood pressure.
Benidipine HCl is a hydrochloride salt form of benidipine which is a dihydropyridine calcium channel blocker.
HC-030031は、選択的なTRPA1 AITCとホルマリンによって引き起こされたチャンネル・ブロッカー カルシウム流入で、IC50 がそれぞれ 6.2 μM と5.3 μMです。
Flunarizine 2HCl is a dihydrochloride salt form which is a calcium channel blocker with a Ki of 68 nM.
Nitrendipineは一種のジヒドロピリジン カルシウム チャネル（ dihydropyridine calcium channel）阻害剤で、IC50値が95nMです。
Strontium Ranelate is a strontium(II) salt of ranelic acid for (-)-desmethoxyverapamil binding to calcium channel with IC50 of 0.5 mM.
Azelnidipine is a dihydropyridine calcium channel blocker.
Tetracaine HCl is a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor.
Disodium Cromoglycate is an antiallergic drug with IC50 of 39 μg/mL.
Diltiazem HCl (Tiazac) is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.
Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator.
Optovin is a reversible photoactivated TRPA1 activator.
Tetrandrine is a calcium channel blocker with an IC50 of 38.23± 25.77 μM.
(B) Measurement of the cellular LDs in 3T3-L1 preadipocytes (undifferentiated) or differentiated adipocytes on day 8 by Oil Red O staining. Phase-contrast images of the cells were also taken after the treatment (lower panels in B). Each picture in (B) is a representative of three independent experiments. (C) Quantification of the cellular TG contents in tetrandrine-treated 3T3-L1 preadipocytes on day 8 by AdipoRed assay. Values are mean ± SE of data from three independent experiments with three replicates. *P < 0.05 vs.control (no chemical). (D) 3T3-L1 preadipocytes were grown under the above-mentioned 3T3-L1 preadipocyte differentiation condition in Figure 1A. On day 8, tetrandrine-treated 3T3-L1 preadipocytes, which cannot be stained with trypan blue dye, was counted under microscope. The cell count assay was done in triplicates. Data are mean ± SE of three independent experiments. *P < 0.05 vs. control (no chemical).
Lomerizine dihydrochloride is a relatively new L- and T-type calcium channel blocker used in the treatment of migraine.
Astragaloside A is a pure small molecular compound isolated from Radix Astragali and is commonly used in the treatment of degenerative bone diseases such as osteoporosis.
Chlorocresol is an activator of ryanodine receptor.