Vorinostat (SAHA, MK0683)

製品コードS1047 別名:SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683)化学構造

分子量(MW):264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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JPY 31706.00
JPY 24402.00
JPY 36520.00

文献中の使用例(100)

カスタマーフィードバック(20)

  • Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

    D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

製品安全説明書

HDAC阻害剤の選択性比較

生物活性

製品説明 Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
ターゲット
HDAC [1]
(Cell-free assay)
~10 nM
体外試験

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 Mm\OT4lv[XOnIFHzd4F6 MVyxJIg> NH[w[oxFVVOR NGTWRmdidnSrLVjERWMyKGGldHn2bZR6KHerdHigTWM2OCCxZjCwMlEyOiEQvF2= NX;seJRvOTF7NkC0PFk>
Friend leukemic cell MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWG1NEDPxE1? M4DYWVczKGh? MVnEUXNQ NXjXbXlnUUN3ME2wMlk6KM7:TR?= MX[xNlExQTlzMx?=
K562 M2HUbGtqdmG|ZTDBd5NigQ>? M1HXSFYhcA>? NV;tUXRkTE2VTx?= NG[5NmZKdmirYnn0bY9vKG:oIHj1cYFvKGirc4TvcoUh\GWjY3X0fYxie2ViKH3pfJR2emVib3[gTGRCSzFiYX7kJGhFSUN{KTD3bZRpKEmFNUCgc4YhOC5yMTFOwG0> M4K4Z|EzPDF7M{iw
HT1080 Ml\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4OycVczKGh? NGPPV5FFVVOR M1yzPWlEPTB;Mj60JO69VQ>? M4\GfVEzOjdyMUe1
H1299 NEfvRXJMcW6jc3WgRZN{[Xl? MljqNlAhdWmw MmnpSG1UVw>? NUTpU3h5UW6qaXLpeI9zgSCjY4Tpeol1gSCjZ3HpcpN1KEiGQVOg[Y57gW2nIIfpeIghUUN3MDDv[kAxNjF7NDFOwG0> MV:xOFUzOTR{Mh?=
H1299 Mk\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jkUlczKGh? NGTLVZZFVVOR MoHjTWM2OD15LkK0JO69VQ>? NHXoUY4yPDV{MUSyNi=>
HeLa M2\KRmtqdmG|ZTDBd5NigQ>? M2LpeVMxKG2rbh?= MUfJcohq[mm2b4L5JINwdmOnboTyZZRqd25iYXfhbY5{fCCqaYP0c45mKGSnYXPleJlt[XOnIIfpeIghUUN3MDDv[kAxNjJ6IN88US=> MojBNVU3ODN7NEm=
LOX-IMVI NWjCb45uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXMUWo1QCCq NIrEN2pKSzVyPUGuN{DPxE1? MoTKNVU4OTV2N{C=
NCI-H226 NWLsZVdRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHHOFghcA>? NYXPVog3UUN3ME2yMlYh|ryP M1y1SlE2PzF3NEew
RXF-631L MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVW0PEBp MYLJR|UxRTJizszN M2XuOFE2PzF3NEew
SNB-78 MnvLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUW3WItJPDhiaB?= NIHIZWpKSzVyPUG2JO69VQ>? NFvIXoIyPTdzNUS3NC=>
St-4 NXLoeW9TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfjbm96PDhiaB?= M2ixcWlEPTB;NT6yJO69VQ>? MUCxOVcyPTR5MB?=
ARP1 NUDuO5l6TnWwY4Tpc44hSXO|YYm= NFLEdpgzKM7:TR?= MnXBOkBp NFPXNG9KdmS3Y4Tpc44hd2ZiUEKxW2FHOSCpZX7lJIV5eHKnc4Ppc44> MUGxOFc{PDhyNh?=
CEM NFTiRY1McW6jc3WgRZN{[Xl? NVLCXmN{OSCq M3fSWWROW09? M1jQPGlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD6zN{DPxE1? MnLCNVY1OjByNkS=
HCT15 NFzubGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DsW|Q5KGh? M{Cw[mdKPTB;MD64NkDPxE1? MlmxNVY4OjN{Mke=
NCI-H23 NHHOcZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIH5UVE1QCCq MUnHTVUxRTBwOUKg{txO MYCxOlczOzJ{Nx?=
GM15850 MXHLbY5ie2ViQYPzZZk> NFr4PJMzNjVizszN MlHPPVYhcA>? MW\EUXNQ NWjiZZlpUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFE1KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NXy5TI5vOTZ7MkGzOlc>
GM15850 NFO2O2VMcW6jc3WgRZN{[Xl? MVmyMlUh|ryP MkLnPVYhcA>? NV[4Tng5TE2VTx?= MofWTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEWgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? NHLyd5AyPjl{MUO2Oy=>
GM15850 NVvzUIl5U2mwYYPlJGF{e2G7 M4rwZ|IvPSEQvF2= MUG5OkBp M17jbWROW09? NYnVSm9sUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFEzKGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NXjGRm9KOTZ7MkGzOlc>
GM15850 NXjnS4ZEU2mwYYPlJGF{e2G7 Ml71Nk42KM7:TR?= Mmj4PVYhcA>? NW[5N4lpTE2VTx?= M1jFVmlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFizJIx6e2mwZTC5JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n M{\ZWFE3QTJzM{[3
GM15850 NFHLNYVMcW6jc3WgRZN{[Xl? NFf3OJgzNjVizszN NXHNflRGQTZiaB?= NUfJSZJiTE2VTx?= NX7SbpZpUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFgh[WOndInsZZRqd25ib3[gSnhPKGenbnW= MmnZNVY6OjF|Nke=
GM15850 NVXDVnhYU2mwYYPlJGF{e2G7 MkPZNk42KM7:TR?= NGPCeFk6PiCq MXvEUXNQ M3;1[mlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTCxOkBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MVOxOlkzOTN4Nx?=
U937 NUPXZ25JTnWwY4Tpc44hSXO|YYm= MmrvOUDPxE1? M2PqUVI1KGh? NVHIfIJFTE2VTx?= M1rwdmNmdGxiY4njcIUh[XK{ZYP0JIJ6KGGlY4XteYxifGmxbjDheEBUN0d{L12gdIhie2V? NEnkOGYyPzByNEexPC=>
H661 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYe0PEBp NULB[HRIUUN3ME2xJO69VQ>? NHHrc5EyPzF3N{CwPS=>
U937 MkLQSpVv[3Srb36gRZN{[Xl? NGfBUJk2KM7:TR?= MWSyOEBp NWDOXpM3TE2VTx?= NUjuN3M3UW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDhZ4V1gWyjdHnvci=> NUjhfHJNOTd2NEe3OVA>
U937 NFLRZW9HfW6ldHnvckBCe3OjeR?= M2\XeFEh|ryP M4TQfFI1KGh? NFK2WFRFVVOR NV7hdIJxTW[oZXP0JI9vKGGucHjhJJR2[nWuaX6gZYNmfHmuYYTpc44> M1y0clE4PDR5N{Ww
RAW264.7 MXjGeY5kfGmxbjDBd5NigQ>? MoDzNVAh|ryP NVjLUmoyOjSq MVT3ZZRmeg>? MlLrTY5pcWKrdHnvckBw\iCOUGOtd5RqdXWuYYTl[EBVVk[jbIDoZUBxem:mdXP0bY9vKHerdHigTWM2OCCxZjCwMlc3KM7:TR?= M2TmPFE4PDd5NUG4
RAW264.7 M2nDc2Z2dmO2aX;uJGF{e2G7 MlS5NVAh|ryP NF3yNYUzPGh? M1nEfpdifGW{ MorsTY5pcWKrdHnvckBw\iCOUGOtd5RqdXWuYYTl[EBPVyCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAyNjh6IN88US=> NHjnNmMyPzR5N{WxPC=>
SC9 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHUOFghcA>? NH7Nc3JKSzVyPUCuOlA3KM7:TR?= M{DyblE4PTB5MkG5
ST14A MUfGeY5kfGmxbjDBd5NigQ>? NEflZ3I2KG6P NIfkbpU4OiCq MXLJcoNz\WG|ZTDpckBTTVOWL17SV2YhdVKQQTDlfJBz\XO|aX;u MYqxO|U3PTl7Mx?=
ST14A MnLzSpVv[3Srb36gRZN{[Xl? MlP2OUBvVQ>? M{ThdFczKGh? MmHMTY5kemWjc3WgbY4hTTKIMTDtVm5CKGW6cILld5Nqd25? M3;lSVE4PTZ3OUmz
PANC1 MmjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rVSlEh|ryP NXX0SmsyUUN3ME2wMlQ2KM7:TR?= MoHxNVc2QDh5NES=
PANC1 M{j1TmZ2dmO2aX;uJGF{e2G7 MUSxJO69VQ>? NV3kU3dqOjRiaB?= NUC1bYRKUW6lcnXhd4UhcW5icEKxW2FHOS:FSWCxJIdmdmViZYjwdoV{e2mxbh?= MkDINVc2QDh5NES=
PANC1 NHnoNlJHfW6ldHnvckBCe3OjeR?= MYOxJO69VQ>? M4nHRVI1KGh? NYfjTGhRUW6lcnXhd4UhcW5icEK3b4lxOSCpZX7lJIV5eHKnc4Ppc44> NYTLeY5XOTd3OEi3OFQ>
PT45 NGXI[HlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHKNndPUUN3ME20JO69VQ>? NV7MVHNbOTd3OEi3OFQ>
ACHN NU\HRWI1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnzNlEhcA>? NVz1NnVWT0l3ME2wMlY2KM7:TR?= MXGxO|Y3OjZyNh?=
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SKHEP1 M4TJOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrafFhjPzJiaB?= MXjJR|UxRTNwNE[g{txO NHrHbXEzODF2M{e3PC=>
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MUF NVvzboxVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnf6NVAxKM7:TR?= NILIPWM1QCCq MYPEUXNQ MlH0S5Jwf3SqIHnubIljcXSrb36gZZQhOC5yNTD0c{AyODBidV2= MkPKNlAyPDN6NEC=
Caco-2 NUf5WVNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Tvb|ExOCEQvF2= NXz3U2RjPDiq MkizSG1UVw>? NGGzVXNKSzVyPUiuNUDPxE1? MXuyNFE1Ozh2MB?=
Caco-2 MlLRT4lv[XOnIFHzd4F6 MUe1JO69VQ>? NYPRTI4{PCCq NFXC[I1FVVOR MXfJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHHj[ZR6dGG2aX;uJGlEPTBib3[gNE4xOzdizszN MV[yNFE1Ozh2MB?=
Caco-2 NYDuenAyU2mwYYPlJGF{e2G7 NFm4U2cxNjNzNjDuUUB1dyB|MT62JO69VQ>? MVK0JIg> Mn;RSG1UVw>? NIfZeoJGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{Gge4l1cCCLQ{WwJI9nKDBwMUG5JO69VQ>? NW\VXpB{OjBzNEO4OFA>
Caco-2 NWH6TXF{U2mwYYPlJGF{e2G7 NWHCfIhVOC5|MU[gcm0hfG9iM{GuOkDPxE1? NXnITWZrPCCq NInOR5JFVVOR M4[zSmV5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFMzD3bZRpKEmFNUCgc4YhOC5zNEeg{txO MljONlAyPDN6NEC=
Caco-2 NHznUIZMcW6jc3WgRZN{[Xl? MWG2MlMzKG6PIITvJFY{OiEQvF2= M4jsZ|QhcA>? NVzoUY5oTE2VTx?= NYG5R2tyTXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVO1JJdqfGhiSVO1NEBw\iBzMj62JO69VQ>? MXyyNFE1Ozh2MB?=
Caco-2 MW\LbY5ie2ViQYPzZZk> MUO2MlMzKG6PIITvJFY{OiEQvF2= MonMOEBp NYXFe3RiTE2VTx?= MmP0SZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN5IIfpeIghUUN3MDDv[kA1OSEQvF2= MY[yNFE1Ozh2MB?=
Caco-2 MUjLbY5ie2ViQYPzZZk> NYnleIU{OC5|MU[gcm0hfG9iM{GuOkDPxE1? NIW4Z|k1KGh? NGPvTZNFVVOR MWTFfEB3cX[xIHnubIljcXSrb36gc4YhcHWvYX6gTGRCSzZ? NV34dIZLOjBzNEO4OFA>
HepG2 NH\Mb2hMcW6jc3WgRZN{[Xl? M2\2bFUh|ryP NYn2NXpCPmh? MkC4SG1UVw>? MnHXTY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgbIl{fG:wZTDhZ4V1gWyjdHnvci=> NEn5XpMzODF2M{i0NC=>
HepG2 MWLLbY5ie2ViQYPzZZk> MXy1JO69VQ>? NHXIflA3cA>? MkfHSG1UVw>? MUjJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHj5dIVz[WOndInsZZRqd25? NHf5bZczODF2M{i0NC=>
HepG2 MVvLbY5ie2ViQYPzZZk> MkH1OUDPxE1? MVi2bC=> NVX6OHdPTE2VTx?= NGf2fWtKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBidHCqYT30eYJ2dGmwIHHj[ZR6dGG2aX;u NFTKUG0zODF2M{i0NC=>
HepG2 NYewNldVU2mwYYPlJGF{e2G7 NHLnRWM2KM7:TR?= MlvyOog> NULrUnBGTE2VTx?= NGW1SG9KdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBJOy:KNDDobZN1d26nIHHj[ZR6dGG2aX;u M4HPblIxOTR|OESw
COLO205 NWqyVW9CU2mwYYPlJGF{e2G7 NHnpNJMyOCEQvF2= M4S1[FI1KGh? MWTEUXNQ NF3PWYNKdmirYnn0bY9vKG:oIFjERWMyKGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBpcXO2b37lJGg{KGGlZYT5cIF1cW:wIIfpeIghUUN3MDDv[kAzNjJizszN MXGyNFQ2OTN5OB?=
SCC4 NHq5N21McW6jc3WgRZN{[Xl? MYWxJO69VQ>? MoizNlRp NX;LcYR3UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJJR2[nWuaX6gZYNmfHmuYYTpc44> NWDWR3BqOjB2NUKyNlU>
SCC4 MkD6T4lv[XOnIFHzd4F6 NHHBVXAyKM7:TR?= M{X3dlI1cA>? M1HibGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIHHj[ZR6dGG2aX;u NH\memEzODR3MkKyOS=>
SCC4 Mn\KSpVv[3Srb36gRZN{[Xl? NFzYcncyKM7:TR?= NGjsOmg2KG2rbh?= NULmNFlXSWexbnnzeEBi[3Srdnn0fUBifCCYRGKgZZN{\XO|ZXSgZZMhcW6mdXP0bY9vKG:oIFPZVFI1KGenbnWg[ZhxemW|c3nvci=> M2PIclIxPDV{MkK1
NB4 NHfNfYhHfW6ldHnvckBCe3OjeR?= Mkj2OUDPxE1? Mk\2NlQhcA>? MUPEUXNQ NHrOZ2ZE\WyuIHP5Z4xmKGG{cnXzeEBie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDhZ4N2dXWuYYTpc44h[XRicILlMWcyKHCqYYPl MnvVNlA1QTF2NEC=
NB4 NGK5c4hMcW6jc3WgRZN{[Xl? NFXDcpo2KM7:TR?= NGHPe4ozPCCq MnHOSG1UVw>? MYHJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iYXPleJlt[XSnIIT1ZpVtcW5ibHX2[Yw> Ml;ENlA1QTF2NEC=
NB4 MYjGeY5kfGmxbjDBd5NigQ>? NXS0cldNPSEQvF2= NFHoflgzPCCq NEPwO5BFVVOR M2n3N2lv\HWldHnvckBw\iCyMkHXRWYyN0OLUEGg[ZhxemW|c3nvci=> NVO4R3RbOjB2OUG0OFA>
NB4 M2HpUmtqdmG|ZTDBd5NigQ>? M1rhcVUh|ryP MlfJNlQhcA>? NH7oZpJFVVOR M2DVTGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFizJIFk\XS7bHH0bY9v NF7wWJMzODR7MUS0NC=>
NUGC3 MmjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\SSWdKPTB;Mj65OEDPxE1? NGHvXXMzODh3MEm3NS=>
A549 M1\FXWZ2dmO2aX;uJGF{e2G7 MWS1JO69VQ>? Mnz6N{Bp NUXMS|JqTE2VTx?= NXHmR4RYUW6mdXP0bY9vKG:oIHH1eI9xcGGpeTDpckBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIFzDN2lK NXHDdYVYOjB6NUWyNFg>
HUT78 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjWcWRoPzJiaB?= NF;hbFdFVVOR MXjHTVUxRTBwMzFOwG0> MkTwNlA5QDR{MEi=
U937 NHXhWXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoeyO|IhcA>? NFjDWWZFVVOR NXrLPZJ6T0l3ME2wMlM6KM7:TR?= NYjw[XhVOjB6OESyNFg>
A431 NIW1UlVEgXSxdH;4bYMhSXO|YYm= M{jB[FczKGh? MkmwR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVQ{OSClZXzsd{BwfmW{ZYjwdoV{e2mwZzDFS2ZTKHerdHigTWM2OCCxZjC0MlIh|ryP MnvxNlExQDB4Mkm=
A549 NXfsUJd6S3m2b4TvfIlkKEG|c3H5 M3\SflczKGh? NVzNWFNuS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTEGFIIfpeIghUUN3MDDv[kAyNjhizszN Mn[3NlExQDB4Mkm=
CAL27 NFfvOXFEgXSxdH;4bYMhSXO|YYm= M3rHSVczKGh? NUnXVWxtS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS0GOMkegZ4VtdHNib4\ldoV5eHKnc4PpcochTUeIUjD3bZRpKEmFNUCgc4YhOy5{IN88US=> NH7jZWMzOTB6ME[yPS=>
HeLa NXvsWIxUS3m2b4TvfIlkKEG|c3H5 MV23NkBp NYi3PJhrS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTEGFIIfpeIghUUN3MDDv[kAyNjVizszN MXqyNVA5ODZ{OR?=
Sf21 NH2ydXVMcW6jc3WgRZN{[Xl? MmflN{Bp MXrJcohq[mm2aX;uJI9nKE[uYXegeIFo\2WmIHj1cYFvKHKnY3;tZolv[W62IFjERWM5KGW6cILld5Nm\CC5aYToJGlEPTBib3[gNU4zKM7:TR?= MmPINlExQDB4Mkm=
SKBR3 MmLER5l1d3SxeHnjJGF{e2G7 M{jlPFczKGh? M4LQOWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMSlJ|IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhGWjJid3n0bEBKSzVyIH;mJFIvPiEQvF2= NX21U5ZtOjFyOEC2Nlk>
SKOV3 MWnDfZRwfG:6aXOgRZN{[Xl? M4jrNlczKGh? NEPjXYtEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0:YMzDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTVJ{IIfpeIghUUN3MDDv[kAzNjJizszN MWiyNVA5ODZ{OR?=
COR-L23 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPkU|RZOTBizszN MkHsO|IhcA>? NWXmV4g6TE2VTx?= NEXOeIFIUTVyPUGuNUDPxE1? MVeyNVA5ODZ2Nx?=
DU145 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1j5fFExKM7:TR?= MXy3NkBp MY\EUXNQ MorzS2k2OD1zLkC1JO69VQ>? NVnpNY9lOjFyOEC2OFc>
LoVo M4PaeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\BNVAh|ryP NG\kWGE4OiCq MlfNSG1UVw>? NY[x[Gc4T0l3ME2xMlch|ryP MmT1NlExQDB4NEe=
MCR5-SV2 Mni2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fsNVExKM7:TR?= MlnEO|IhcA>? MXzEUXNQ M{jsbmdKPTB;Mj6xJO69VQ>? Mo\4NlExQDB4NEe=
HCT116 MlTuT4lv[XOnIFHzd4F6 MlLSN|Ah|ryP NIPFTGU{OCCq NWLrR2lsTE2VTx?= M3rDVGlvcGmkaYTpc44hd2ZiSFTBR|Yh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIFteGijLYT1ZpVtcW5iYXPleJlt[XSrb36= NHTHbHozOTB6ME[0Oy=>
HCT116 NGezOopMcW6jc3WgRZN{[Xl? NVS4eYRzOzBizszN M33Jc|MxKGh? NXLU[|FHTE2VTx?= NUXjcG1lUW6qaXLpeIlwdiCxZjDISGFEOSCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhcGm|dH;u[UBJO0t7IHHj[ZR6dGG2aX;u M1Tn[VIyODhyNkS3
U937 M{\zS2tqdmG|ZTDBd5NigQ>? NIrmSWc2KM7:TR?= MmfqNlQhcA>? NYfvfmc3TE2VTx?= MkDlTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJIFk\XS7bHH0bY9vKG:oIHjpd5RwdmViSEOgZZQhUzl? M2rOe|IyOjl{NEmy
U937 MnHMT4lv[XOnIFHzd4F6 NUfi[JpIPSEQvF2= NIG2UY0zPCCq NXK2PFJQTE2VTx?= NXP4RXdSUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{G4 NWXhZ|Y1OjF{OUK0PVI>
U937 NG\jRYJMcW6jc3WgRZN{[Xl? M1z2[lUh|ryP Ml3DNlQhcA>? NGPDb5FFVVOR MoD1TY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJJBidi2jY3X0fYxifGWmIHjpd5RwdmViSESgcIV3\Wx? M{XYdVIyOjl{NEmy
U937 NIS3N4JMcW6jc3WgRZN{[Xl? MVS1JO69VQ>? NH\UZWgyPSCvaX6= NHWyeWxFVVOR NVTnZVZzUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGirc4TvcoUhUDNiYXPleJlt[XSrb36gcIV3\Wx? NHrXfmszOTJ7MkS5Ni=>
A2780 NXfoSJkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHlPVYhcA>? MUnEUXNQ NUPPcWR5UUN3ME2xMlYzKM7:TR?= MX[yNVY{PDR|MB?=
COLO205 M3H2W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVK5OkBp NH3jSIRFVVOR M3LCfWlEPTB;Mj6xNkDPxE1? NVfCcZVjOjF4M{S0N|A>
Hep3B M{W1XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjsdJQ1QCCq MXrEUXNQ MkP6S2k2OD1zLkKxJO69VQ>? NIrTT5ozOTdzMkG0Oi=>
GM11272 NUf6PY1YTnWwY4Tpc44hSXO|YYm= M2WwfFExOCCwTR?= M2T0PFczKGh? NX:wcpNOTE2VTx?= NGXTT2hT\WGldHn2ZZRqd25ib3[gUYVEeDJibYX0ZY51KGW6cILld5Nqd25iYYSgNVAhfG9iMUCwJI5O MoW3NlE5PDB5MU[=
CFBE41o NEHYUnZMcW6jc3WgRZN{[Xl? NF7kelU2KM7:TR?= MnnCSG1UVw>? NVPkUGVCTG:5bjDy[Yd2dGG2aX;uJI9nKEiGQVO3JIF1KDBwMjD0c{A2KHWP NInJSlYzOTl6NEm1PC=>
CFBE41o NETvTFRHfW6ldHnvckBCe3OjeR?= Mk\xNUDPxE1? MXWyOEBp NH3RUZZFVVOR MVfS[ZN1d3KjdHnvckBw\iCFRmTSJIRmdHSjRkWwPEBufXSjboSgeJJi\m[rY3vpcochfG9iY3XscEB{fXKoYXPlJIF{KGeueXPv[o9zdXN? MWeyNVk5PDl3OB?=
DU145 MV7LbY5ie2ViQYPzZZk> NWXhfllmOi53IN88US=> M1XWPFI1KGh? MXrEUXNQ NWPwZm9DUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IIXwdoVofWyjdHnvckBw\iCyMkH3ZYYyKHC{b4TlbY4h\XiycnXzd4lwdg>? NHuxVYMzOjJ4MEG2Oi=>
DU145 NV;qdJFzU2mwYYPlJGF{e2G7 NVm5SpNXPSEQvF2= NX7rSYRHOjRiaB?= Mm[0SG1UVw>? MUPJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcGm|dH;u[UBJPCCjY3X0fYxifGmxbh?= M1vCRlIzOjZyMU[2
DU145 NY\qZYN3U2mwYYPlJGF{e2G7 M3TVT|Uh|ryP MWKyOEBp NWezTZVETE2VTx?= NVrmblVzUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHjpd5RwdmViSEOgbJlx\XKjY3X0fYxifGmxbh?= NVmwT3p[OjJ{NkCxOlY>
786-0 M2n2b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\MOk4zKM7:TR?= NGLLTpM4OiCq NEKy[5dFVVOR NIrEUnhIUTVyPUOuNkDPxE1? MWGyNlQ{PTZ4OR?=
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A549/ATCC MkL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHj5[Gk3NjJizszN MXS3NkBp MXrEUXNQ MWnHTVUxRTFwNjFOwG0> M1fzbVIzPDN3Nk[5
ACHN M{jrU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfjN3V3Pi5{IN88US=> Mn7kO|IhcA>? NGLV[4dFVVOR NH:weJpIUTVyPUGuN{DPxE1? NIGzXFUzOjR|NU[2PS=>
BT549 NHPXTINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTjZ25[Pi5{IN88US=> M1PHXVczKGh? Ml\zSG1UVw>? M1fmUmdKPTB;MT6zJO69VQ>? MXeyNlQ{PTZ4OR?=
EKVX MoDYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fVbFYvOiEQvF2= NUHxc4d5PzJiaB?= NI\3bVJFVVOR MVXHTVUxRTFwMzFOwG0> Mn\QNlI1OzV4Nkm=
HCT15 NXfVSI9mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnae3dwPi5{IN88US=> NX;Yb5p4PzJiaB?= NYPYWoZlTE2VTx?= MXXHTVUxRTJwNTFOwG0> NHnzRYgzOjR|NU[2PS=>
HOP92 Ml21S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITlUJo3NjJizszN NGLm[GE4OiCq MmPCSG1UVw>? MV;HTVUxRTRizszN M4fLVFIzPDN3Nk[5
IGROV1 MnH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXe2MlIh|ryP M{LZOVczKGh? MX7EUXNQ MUXHTVUxRTFwMzFOwG0> M3m2e|IzPDN3Nk[5
LOXIMVI M{PpXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\hSJI3NjJizszN Mmf1O|IhcA>? MnHuSG1UVw>? M4n2UGdKPTB;MTFOwG0> NUXa[3ZnOjJ2M{W2Olk>
M14 M{jyWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnyOk4zKM7:TR?= MXS3NkBp M1;XRmROW09? M376e2dKPTB;MT6zJO69VQ>? MoS3NlI1OzV4Nkm=
MALME-3M MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGL4bIg3NjJizszN M17rPFczKGh? NGfzUHpFVVOR M4jsN2dKPTB;MD6zNkDPxE1? MVOyNlQ{PTZ4OR?=
MCF10A Mn3US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7VOk4zKM7:TR?= NHHEeFQ1QCCq M2jtWmROW09? Mkm1S2k2OD17Lk[g{txO NWDFNIxrOjJ2M{W2Olk>
MDA-MB-435 M1;YWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrvVWI3NjJizszN MXe3NkBp MXvEUXNQ M{PlemdKPTB;MD61JO69VQ>? MUGyNlQ{PTZ4OR?=
MDA-MB-468 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;jOk4zKM7:TR?= NVP0bJVFPzJiaB?= NV;jWHhoTE2VTx?= M4XhdWdKPTB;MD62N{DPxE1? M2DBfFIzPDN3Nk[5
MOLT4 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;5RVI3NjJizszN NVPxU5djPzJiaB?= M2\lRmROW09? MW\HTVUxRTBwNDFOwG0> MXmyNlQ{PTZ4OR?=
NCI-ADR-RES MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DYVlYvOiEQvF2= NF7ZU2s4OiCq M172cGROW09? NGrIN|hIUTVyPUCuNVYh|ryP MYiyNlQ{PTZ4OR?=
NCI-H23 NVW2[Wl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXG0UnB{Pi5{IN88US=> Mof6O|IhcA>? MVLEUXNQ MoPNS2k2OD1zIN88US=> MYWyNlQ{PTZ4OR?=
NCI-H322M MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTGTW83NjJizszN MmX2O|IhcA>? M4rjW2ROW09? MlnUS2k2OD1yLke5JO69VQ>? MnzZNlI1OzV4Nkm=
NCI-H460 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1exWVYvOiEQvF2= NHvzNno4OiCq NHWwXYNFVVOR MXTHTVUxRTBwN{mg{txO MnLaNlI1OzV4Nkm=
NCI-H522 NV;rOZNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXO2MlIh|ryP NFrFUYk4OiCq MlPtSG1UVw>? NUfIfld{T0l3ME2wMlUh|ryP NUThfWZ7OjJ2M{W2Olk>
OVCAR3 NXvOe4JDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYW2MlIh|ryP NH\je3k4OiCq NVvXe3NiTE2VTx?= MlHSS2k2OD1zLkOg{txO MYeyNlQ{PTZ4OR?=
OVCAR4 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;YTVYvOiEQvF2= MnHRO|IhcA>? NHfWcHVFVVOR Mk\KS2k2OD12IN88US=> Mnv0NlI1OzV4Nkm=
OVCAR5 NVrVUZJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWD5UHZXPi5{IN88US=> NELhZoM4OiCq NIjGWWFFVVOR MoPuS2k2OD1yLke5JO69VQ>? NEfxS4gzOjR|NU[2PS=>
OVCAR8 NF7uWHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nEOFYvOiEQvF2= MUW3NkBp NGPUWmFFVVOR MkjiS2k2OD1yLkWg{txO NUnQO4VnOjJ2M{W2Olk>
RXF393 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1r2e|YvOiEQvF2= NYf1Z5ZTPzJiaB?= NFXrTXBFVVOR M3e3NWdKPTB;MT6zJO69VQ>? MnX4NlI1OzV4Nkm=
SF268 NGHhSm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV22MlIh|ryP NF\scGE4OiCq NXPz[mtTTE2VTx?= NHfvUnhIUTVyPUGuOkDPxE1? NG\pZXIzOjR|NU[2PS=>
SF295 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1j5c|YvOiEQvF2= M{PyN|czKGh? NH;sSItFVVOR MnPHS2k2OD1zLk[g{txO M3\sUFIzPDN3Nk[5
SF539 NFXqPIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYS2MlIh|ryP MljTO|IhcA>? NYnPRmtITE2VTx?= MlXyS2k2OD1{IN88US=> NXPHPY5FOjJ2M{W2Olk>
SK-MEL-2 NHvyUHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MleyOk4zKM7:TR?= MnrvO|IhcA>? M3\4SGROW09? MXvHTVUxRTFwMzFOwG0> NIrodJMzOjR|NU[2PS=>
SK-MEL-28 NHLtcnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDWVXU3NjJizszN NW\4R4V5PzJiaB?= NH;Nb|BFVVOR MYPHTVUxRTFizszN MnnmNlI1OzV4Nkm=
SK-MEL-5 M4fLTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEH0[|c3NjJizszN NHHOXlY4OiCq MmnTSG1UVw>? NW[4bWhST0l3ME2wMlY{KM7:TR?= M1nENlIzPDN3Nk[5
SKOV3 NXj6S5RqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTvRlk3NjJizszN MYC3NkBp NFPCd5JFVVOR NX\STXVFT0l3ME2xJO69VQ>? MUiyNlQ{PTZ4OR?=
SN12C NVLVVmllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnDOk4zKM7:TR?= NGrScZo4OiCq NYTiTGI2TE2VTx?= MYrHTVUxRTJizszN NYfscIpKOjJ2M{W2Olk>
SNB19 NWrMe2FqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDZbIZCPi5{IN88US=> M3foV|czKGh? M3jEOWROW09? NVrhO2x{T0l3ME2wMlY{KM7:TR?= NVHuc5lxOjJ2M{W2Olk>
SNB75 NGPrU21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mny3Ok4zKM7:TR?= NYiwepZ6PzJiaB?= M1rr[GROW09? M4jRWGdKPTB;MD63PUDPxE1? M{[5WVIzPDN3Nk[5
SR MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPsZ4o3NjJizszN M4XuZ|czKGh? M17abmROW09? NUPPd|I3T0l3ME2wMlQh|ryP Mm\jNlI1OzV4Nkm=
T47D MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2f0WlYvOiEQvF2= MoPrO|IhcA>? MlHBSG1UVw>? NUfIfWJST0l3ME2wMlUh|ryP NGnvdFEzOjR|NU[2PS=>
TK10 MmX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUW2MlIh|ryP NHfmTnM4OiCq NFrxbpdFVVOR MVTHTVUxRTBwNkOg{txO NHvl[JEzOjR|NU[2PS=>
UACC257 NWX5[|NyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHIWWd2Pi5{IN88US=> NUjJVYF5PzJiaB?= NWnBUHpRTE2VTx?= MWnHTVUxRTBwNTFOwG0> MVGyNlQ{PTZ4OR?=
UACC62 NVzTZZBJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7jOk4zKM7:TR?= NUjCfVhTPzJiaB?= NH\NO2FFVVOR NHW3TI1IUTVyPUCuOEDPxE1? M1\JR|IzPDN3Nk[5
UO31 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7ROk4zKM7:TR?= M37qbFczKGh? NXrzR3FtTE2VTx?= MkO1S2k2OD1yLkWg{txO MoHoNlI1OzV4Nkm=
Hep3B MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3pOFghcA>? MoS5SG1UVw>? NWDNbohYT0l3ME2wMlY6KM7:TR?= NVy1c4diOjJ2M{m4OlM>
BE(2)-C MmHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXCWWI4OiCq NGe1cVZFVVOR NWnhOHlHUUN5ME2yJO69VQ>? MXmyNlk{OjNzNh?=
Bel7402 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vNelczKGh? NU[0W4VSTE2VTx?= NXXyWWpIT0l7ME2xO{DPxE1? MlLLNlMxPjF|N{[=
Bel7404 M1jXSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXqO|IhcA>? M4m1RWROW09? MnXmS2k6OD1zODFOwG0> MoLoNlMxPjF|N{[=
BGC823 NX[1RXJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrEbIxqPzJiaB?= M164TWROW09? Mn22S2k6OD15LkWg{txO NHTtUmIzOzB4MUO3Oi=>
MGC803 Ml7YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrvbnY4OiCq NGHseVFFVVOR NY[5bWZ{T0l7ME2xNE45KM7:TR?= NXjp[JlwOjNyNkGzO|Y>
SGC7901 MmHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fNbFczKGh? M2qxW2ROW09? M4DYNmdKQTB;OT60JO69VQ>? M3TuPVI{ODZzM{e2
SKHEP1 MoPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLWO|IhcA>? NVz5SZI3TE2VTx?= MUTHTVkxRTF5IN88US=> MXqyN|A3OTN5Nh?=
SMMC7721 NHnOb3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFv3W4g4OiCq NHPRNI1FVVOR M{LrSGdKQTB;MkCg{txO NYjI[Hp2OjNyNkGzO|Y>
NUGC3 NUnPVlZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1q5ZlExKM7:TR?= NVH0[HBDT0l;Mj65OEDPxE1? MV:yN|E3OzN|Mh?=
A2780 CisR NWXNW21{U2mwYYPlJGF{e2G7 NI\sNVMyQCCq M4L5e2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD60OEDPxE1? MVGyN|I2OjZyMx?=
CAL27 sens NXLwRndvU2mwYYPlJGF{e2G7 NH3tVlUyQCCq NI[xOnFKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuN|Yh|ryP M2D4UFI{OjV{NkCz
CAL27 CisR MX3LbY5ie2ViQYPzZZk> NGHXbXoyQCCq M1XBZ2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? MVOyN|I2OjZyMx?=
KYSE-510 CisR M4TKfGtqdmG|ZTDBd5NigQ>? M1fDVFE5KGh? NUfpNnhHUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlU6KM7:TR?= Mo\HNlMzPTJ4MEO=
KYSE-510 sens M1j0eGtqdmG|ZTDBd5NigQ>? Mn;YNVghcA>? NIjGXGNKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuO{DPxE1? MmDwNlMzPTJ4MEO=
MDA-MB-231 sens M1\wXmtqdmG|ZTDBd5NigQ>? M1TYUVE5KGh? M2Kyb2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? NWK1eoRHOjN{NUK2NFM>
MDA-MB-231 CisR MVjLbY5ie2ViQYPzZZk> MUGxPEBp MoXJTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>? NVzvcpZJOjN{NUK2NFM>
ES2 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrCcJo1QCCq Mn;lSG1UVw>? M1K2SmlEPTB;MUKuO{DPxE1? NGP6Ro0zOzR7M{S0PS=>
MDA-MB-231 MUXLbY5ie2ViQYPzZZk> NFzNb3YyOCEQvF2= MmO4N|AhdWmw M2TGZmROW09? NED1ZZNKdmirYnn0bY9vKG:oIFjERWMz[Q>? MoDiNlM1QTN2NEm=
MDA-MB-231 NIDQSGtMcW6jc3WgRZN{[Xl? NVi1NJFvOSEQvF2= NW\L[mtqOjRiaB?= NY\WfFVzTE2VTx?= MnjPTY5pcWKrdHnvckBw\iCKRFHDOkBie3Onc4Pl[EBieyCjY3X0fYxifGmxbjDs[ZZmdHNib3[geJVjfWyrbh?= NInqcZozOzR7M{S0PS=>
HS68 NYTmXXFTS3m2b4TvfIlkKEG|c3H5 NH\kfJUyOCEQvF2= MWe3NkBp NFnhWoVFVVOR NU\OSY1SUUN3ME20MlYh|ryP NIThR4wzOzV5MEW0Ni=>
MEF MUPDfZRwfG:6aXOgRZN{[Xl? MoHkNVAh|ryP M{juV|czKGh? Ml3XSG1UVw>? NUWzbXVNUUN3ME20MlQh|ryP M4\F[VI{PTdyNUSy
BGC823 M3zkUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M360TmROW09? NFPvRm5IUTVyPUOuNFkh|ryP MXuyN|YxOTdyNh?=
High5 MkfoT4lv[XOnIFHzd4F6 M2ftdFI1KGh? M4C1RmlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSFTBR|Yhf2m2aDDJR|UxKG:oIECuNFkh|ryP NFT0[I4zOzZyMkWyNy=>
High5 MXLLbY5ie2ViQYPzZZk> NGrVTYczPCCq NYLuXGxwUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEOSC5aYToJGlEPTBib3[gNE4yOiEQvF2= M33WXlI{PjB{NUKz
High5 MofNT4lv[XOnIFHzd4F6 NXvtTZltOjRiaB?= NHPXXYNKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM{KHerdHigTWM2OCCxZjCwMlE4KM7:TR?= NHPDZowzOzZyMkWyNy=>
A549 NYTJcWNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzEUXNQ MYHJR|UxRTFwMEe5JO69VQ>? NWn2dG81OjN4NESyNVA>
HCT116 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\KRWtFVVOR NWPlflBkUUN3ME2wMlc2PyEQvF2= NGDLZZMzOzZ2NEKxNC=>
K562 NW[wWJRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrEUXNQ Mon2TWM2OD1yLk[0OUDPxE1? M{jjfFI{PjR2MkGw
GBC-SD MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYG1JO69VQ>? NIj3UIs4OiCq NWXHWY5JTE2VTx?= NHu5fItKSzVyPUG0Mlgh|ryP MnW2NlM4ODd{NkC=
HGC27 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfPXY82KM7:TR?= Ml6wO|IhcA>? NIm3PY1FVVOR Ml;pTWM2OD13LkSg{txO Moj2NlM4ODd{NkC=
HL60 MoTkT4lv[XOnIFHzd4F6 NEW4eng2KM7:TR?= NHzY[|gzPCCq MXPEUXNQ MlfYTY5pcWKrdHnvckBw\iCKRFHD Mnq1NlM4ODd{NkC=
Vero NFP6TYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojDO|IhcA>? NWX5VIM6TE2VTx?= NEX0PGZKSzVyPUCuPUDPxE1? MmrHNlM4QDZ2NUK=
NCI60 NXqyb2dUS3m2b4TvfIlkKEG|c3H5 MUm0PEBp MlTxSG1UVw>? MofuS2k:OC53MzFOwG0> NF\OV5UzPDBzNUOyOy=>
SW620 MXvDfZRwfG:6aXOgRZN{[Xl? NGSyOZg1QCCq Ml;uSG1UVw>? NVPTZmY4T0l;MD61OEDPxE1? Mn;FNlQxOTV|Mke=
U251 MnnFR5l1d3SxeHnjJGF{e2G7 NEDkbVM1QCCq NVLHflBtTE2VTx?= NF62ZZpIUT1zLkWzJO69VQ>? M2LuR|I1ODF3M{K3
KM12 Mmq2R5l1d3SxeHnjJGF{e2G7 NXnCUHB5PDhiaB?= MofHSG1UVw>? M1[2PGdKRTFwOEig{txO NHHafZUzPDBzNUOyOy=>
Hs578T NYLZeZZPS3m2b4TvfIlkKEG|c3H5 NFfD[5M1QCCq M2fWU2ROW09? MY\HTV01Njh|IN88US=> NYrje3l7OjRyMUWzNlc>
MDA-MB-231 NE\WbIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;FcopOPDhiaB?= M4nQUmlEPTB;MD6xOkDPxE1? MVyyOFA6PTBzNh?=
MCF7 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVH3VpVFPDhiaB?= M1H1dGdKRTBwNEWg{txO MVyyOFEyQTV3NR?=
MDA-MB-435 NV32NW5YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFy5NFc1QCCq MYnHTV0xNjh6IN88US=> NFLX[YozPDFzOUW1OS=>
AsPC1 M{TCZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE[yeIg{OCEQvF2= NVHqZmR[PDhiaB?= NFOzXHpFVVOR NWToc2J2UUN3ME2zMlY3KM7:TR?= MXGyOFE5PTN5OB?=
Jurkat E6.1 M4jPbWtqdmG|ZTDBd5NigQ>? MmPNNkBp NFvKfZZFVVOR NW\3SZFIUW6qaXLpeIlwdiCxZjDISGFEPCC5aYToJGlEPTBib3[gNE4xPCEQvF2= NYP0ZXE4OjR{NkG4OlI>
KG1 NYHDdnAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1L0[VQ5KGh? M4DTbGlEPTB;MT6xOUDPxE1? MmTXNlQ2OjVyMEO=
HEL M2DIUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jTRVQ5KGh? M3;jPGROW09? MX;JR|UxRTBwNEmg{txO NH7nT5QzPDZ7NEC1OS=>
HSC3 NWTZT3lTS3m2b4TvfIlkKEG|c3H5 MYqxNkBp NIT1XWNFVVOR NYPoN2NDUUN3ME2wMlcyKM7:TR?= M3[5S|I1PzZ4NU[w
HT-29 M2jzfWN6fG:2b4jpZ{BCe3OjeR?= NFzTXGUyOiCq MorWSG1UVw>? NHq1W|JKSzVyPUCuO|Ih|ryP M33WblI1PzZ4NU[w
KB NFTT[nBEgXSxdH;4bYMhSXO|YYm= MVGxNkBp MYLEUXNQ MUPJR|UxRTBwN{Wg{txO Mln6NlQ4PjZ3NkC=
H460 Mnj0R5l1d3SxeHnjJGF{e2G7 NV\2TJRZOTJiaB?= M2HkbGROW09? M1fHbmlEPTB;MD64NkDPxE1? NWfmbldFOjR5Nk[1OlA>
MONE1 MkjwR5l1d3SxeHnjJGF{e2G7 MlTINVIhcA>? M1rGWWROW09? NEnoZnVKSzVyPUGuNVgh|ryP NHXLTm4zPDd4NkW2NC=>
MKN45 M1GyfmN6fG:2b4jpZ{BCe3OjeR?= Mnm5NVIhcA>? MlO0SG1UVw>? MXXJR|UxRTFwMkWg{txO MoHTNlQ4PjZ3NkC=
TSGH MXnDfZRwfG:6aXOgRZN{[Xl? MlrmNVIhcA>? NV7K[3Q2TE2VTx?= MWrJR|UxRTJwMEmg{txO MUiyOFc3PjV4MB?=
HL60 MoP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nJUFczKGh? NXHnXHQ2TE2VTx?= NYrzTYZTT0l3ME2wMlk{KM7:TR?= M4[wXFI1QTByNUCw
HEK293 M4fGemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zYT|czKGh? MXfEUXNQ M2TPT2dKPTB;MUOg{txO NXTt[YZmOjR7MEC1NFA>
Jurkat M1\ETWN6fG:2b4jpZ{BCe3OjeR?= MYCxNFAh|ryP NXe2ZmNEPzJiaB?= NYDMVpZET0l3ME2wMlkh|ryP M2XxXFI1QTByN{Sz
GM15850 MYrLbY5ie2ViQYPzZZk> MY[yMlUh|ryP MmP2PVYhcA>? M3H5UGROW09? Mn7X[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFE1KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NXzSSYxnOTZ7MkGzOlc>
GM15850 MUDLbY5ie2ViQYPzZZk> NHnD[m4zNjVizszN MU[5OkBp MWfEUXNQ MkLj[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFUh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NFzPfY4yPjl{MUO2Oy=>
GM15850 NXrrUGpyU2mwYYPlJGF{e2G7 MkT1Nk42KM7:TR?= Mn3pPVYhcA>? M122RWROW09? NUCzZ2xE\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDRibInzbY5mKDF{IHHj[ZR6dGG2aX;uJI9nKE[[TjDn[Y5m NV\WPXFHOTZ7MkGzOlc>
GM15850 NGDOTllMcW6jc3WgRZN{[Xl? MoThNk42KM7:TR?= NYSz[XRmQTZiaB?= M3LtfmROW09? NGHmS4dld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJOyCueYPpcoUhQSCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> NYPHfXdKOTZ7MkGzOlc>
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VM-CUB-1 NXyxR3BbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTFwMUmxNFgh|ryP M4\F[3NCVkeHUh?=
NB5 MkfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVv2bJJLUUN3ME2xMlE6QDV4IN88US=> M1;xUnNCVkeHUh?=
SKG-IIIa MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfCU4RKSzVyPUGuNlM1PjRizszN M4TETnNCVkeHUh?=
HO-1-N-1 NFrqU2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTFwMkO4N|Uh|ryP NFjWT3JUSU6JRWK=
EFO-27 MmPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TmSmlEPTB;MT6yOVA1OyEQvF2= NYq1[I9uW0GQR1XS
MHH-NB-11 NV;1dYs6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHtTWM2OD1zLkK4N|I6KM7:TR?= MnHDV2FPT0WU
SW620 Mor3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTFwMkmwNVgh|ryP MXXTRW5ITVJ?
MOLT-16 M2P0TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PmSWlEPTB;MT6yPVc6PyEQvF2= NU\ve2I3W0GQR1XS
NTERA-S-cl-D1 M321cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\XTWM2OD1zLkOxO|YyKM7:TR?= NW\Jb5FzW0GQR1XS
VA-ES-BJ MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnT2TWM2OD1zLkOyOFc4KM7:TR?= MW\TRW5ITVJ?
HCC1419 M1OweGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PMZmlEPTB;MT6zOFAzPyEQvF2= M1zsZXNCVkeHUh?=
NCI-H69 MkX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrJTYZkUUN3ME2xMlM1OTF{IN88US=> MnHCV2FPT0WU
DEL MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrqTWM2OD1zLkO1NVYzKM7:TR?= MWnTRW5ITVJ?
LXF-289 NWXaXGU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTFwM{WyOEDPxE1? MWPTRW5ITVJ?
EW-11 M4LoPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljxTWM2OD1zLkO2NFI3KM7:TR?= NVfjcHlWW0GQR1XS
KP-4 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NECwPXJKSzVyPUGuN|cxQDVizszN M{fnb3NCVkeHUh?=
NOS-1 NVP1boJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTFwNEGxPVQh|ryP MYHTRW5ITVJ?
SK-NEP-1 NIfSZnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEC5eZNKSzVyPUGuOFE3QTNizszN MVTTRW5ITVJ?
LAMA-84 MoHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUf6bGJNUUN3ME2xMlQ{QTR3IN88US=> MVrTRW5ITVJ?
ES5 NYfuPXp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmS5TWM2OD1zLkS0N{DPxE1? M4PZT3NCVkeHUh?=
HuO9 M{jwTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW[w[XVOUUN3ME2xMlQ2OzZ{IN88US=> NUPSTnJtW0GQR1XS
COLO-684 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTFwNE[xNVgh|ryP MXnTRW5ITVJ?
EW-24 M1ftPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLhUnd[UUN3ME2xMlQ3PTNzIN88US=> MX;TRW5ITVJ?
BV-173 NFX1UYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTFwNEeyPVEh|ryP M{K5[nNCVkeHUh?=
NCI-H1770 NUD4ZndLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\IdmlEPTB;MT60PFU{PiEQvF2= MlPIV2FPT0WU
HuP-T4 NFLqbVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYP0U5dtUUN3ME2xMlQ6OyEQvF2= M13KSXNCVkeHUh?=
TYK-nu M3fiUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYq5WlAzUUN3ME2xMlQ6QDVzIN88US=> MnziV2FPT0WU
YH-13 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDDZ5lrUUN3ME2xMlQ6QDl2IN88US=> NH;KboxUSU6JRWK=
H4 NWj4bJd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjyNIJ2UUN3ME2xMlUxQTF{IN88US=> NWrpPY5{W0GQR1XS
OVCAR-8 M4DQd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYezdFI3UUN3ME2xMlU1PDd5IN88US=> NU\FUWdoW0GQR1XS
NCI-H23 M4nrRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmH4TWM2OD1zLkW0OlQ2KM7:TR?= MnPEV2FPT0WU
ES7 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PFSWlEPTB;MT61OFc4OyEQvF2= NFjKVpdUSU6JRWK=
COR-L88 M4XkdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWG0SXdFUUN3ME2xMlU3PDJ2IN88US=> M2e0bHNCVkeHUh?=
TI-73 MoTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTFwNUmwOkDPxE1? NIj2d4dUSU6JRWK=
RT-112 Mli2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjDVYlZUUN3ME2xMlU6Ojh2IN88US=> NF6w[ZBUSU6JRWK=
HuO-3N1 MkfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\yTWM2OD1zLkW5N|g2KM7:TR?= M3fyNnNCVkeHUh?=
HC-1 NGjYNmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLTTWM2OD1zLkW5PFY3KM7:TR?= M{nDNXNCVkeHUh?=
HT55 NFThSoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknRTWM2OD1zLk[1NVMyKM7:TR?= MVHTRW5ITVJ?
IA-LM MknQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTFwNkmyO|gh|ryP NWXaTXpjW0GQR1XS
EM-2 M2D2T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEOxPHZKSzVyPUGuO|AxOTRizszN NYTIbmd5W0GQR1XS
MHH-ES-1 NEHlNFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;6ZmlKSzVyPUGuO|A1OzVizszN NVzadHJ6W0GQR1XS
CAL-27 Ml;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPsNZVKSzVyPUGuO|A3OjFizszN MYnTRW5ITVJ?
COLO-800 M3;nemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDMTWM2OD1zLkexNVc6KM7:TR?= NF:xZmJUSU6JRWK=
HCE-T MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTFwN{G1JO69VQ>? MnHhV2FPT0WU
CAMA-1 MljMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fBe2lEPTB;MT63NVk4OSEQvF2= M4\UfHNCVkeHUh?=
LOXIMVI NX3DTI43T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn32TWM2OD1zLkeyNVEh|ryP M4O4e3NCVkeHUh?=
NH-12 NEXPbHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkS3TWM2OD1zLkeyOlkyKM7:TR?= MV7TRW5ITVJ?
TCCSUP M1S2WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILSdXBKSzVyPUGuO|I5OjlizszN MonVV2FPT0WU
MDA-MB-361 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDqTWM2OD1zLkezNVU4KM7:TR?= NVXOSYZxW0GQR1XS
EW-16 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTHS5JKSzVyPUGuO|QyODdizszN MnLFV2FPT0WU
SNU-423 NITqR5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\mTWM2OD1zLke1PFI4KM7:TR?= MlfNV2FPT0WU
Daoy M{jkRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnOxTWM2OD1zLke2N|E6KM7:TR?= NEDOW5dUSU6JRWK=
ES4 NInSWJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYC2fYRZUUN3ME2xMlc5PzRzIN88US=> MXvTRW5ITVJ?
PFSK-1 NV;YfGRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnWOY82UUN3ME2xMlgxOzdizszN M4LjW3NCVkeHUh?=
ES3 MoPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTreIhNUUN3ME2xMlgzPjhzIN88US=> MnjQV2FPT0WU
ONS-76 Mn3FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlX0TWM2OD1zLkiyPFk4KM7:TR?= MlrEV2FPT0WU
JVM-3 MoHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTFwOEW0OVEh|ryP NX6zVm5YW0GQR1XS
OS-RC-2 NHu1NFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjMTWM2OD1zLki3NVUyKM7:TR?= M1PMfXNCVkeHUh?=
COLO-320-HSR M2S2VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXiTWM2OD1zLki4NVk4KM7:TR?= NVPwfHBQW0GQR1XS
HN NFn0R|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTFwOEi3NlUh|ryP NV\CVldKW0GQR1XS
HT NFewXZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDDPXJKSzVyPUGuPFg6PDdizszN MXLTRW5ITVJ?
LoVo NIDO[XdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\2[FFKSzVyPUGuPFk5OSEQvF2= M{T1e3NCVkeHUh?=
CGTH-W-1 M4q3Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHv1NWhKSzVyPUGuPFk6PDZizszN MlfNV2FPT0WU
NB6 NYXrWGxqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vyeWlEPTB;MT65NVI6QCEQvF2= MY\TRW5ITVJ?
EW-22 M{jUfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDTR4VjUUN3ME2xMlkzQDh5IN88US=> NGjzdnRUSU6JRWK=
ES6 M4HDV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;oTWM2OD1zLkmzOlMyKM7:TR?= M2LnTnNCVkeHUh?=
SCC-15 M2jtPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHzd|lKSzVyPUGuPVM5OTlizszN MmqwV2FPT0WU
HL-60 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDZTWM2OD1zLkmzPVAzKM7:TR?= MmLnV2FPT0WU
human HOP-92 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXReJFKSzVyPUGuPVQxPjVizszN NXLnRo9uW0GQR1XS
SW626 Ml3sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTFwOUS4PVkh|ryP NIjDR4JUSU6JRWK=
HEC-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\FN2lEPTB;MT65OVM3KM7:TR?= M{naO3NCVkeHUh?=
LB2241-RCC NVrvRndST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTFwOUiyN|Eh|ryP M2j4eHNCVkeHUh?=
Ramos-2G6-4C10 NFn6SGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrWemVsUUN3ME2xMlk6PDl|IN88US=> Mn\NV2FPT0WU
A101D NWXLc3l3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvXdpU2UUN3ME2yMlIxOzB|IN88US=> NGe4cGFUSU6JRWK=
NCI-H446 MlfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYWyOJJWUUN3ME2yMlA1PTl7IN88US=> NGT4Zm9USU6JRWK=
SBC-5 NGnGNXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXNTWM2OD1{LkC2NVQ4KM7:TR?= M{HFXXNCVkeHUh?=
HOS NIm2S2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33EfWlEPTB;Mj6wO|Y2OyEQvF2= MV;TRW5ITVJ?
K5 NGnCVVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLydZZSUUN3ME2yMlA4QDFzIN88US=> NXG3TWdRW0GQR1XS
HLE NGfrd29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXkTWM2OD1{LkC4OVI6KM7:TR?= NGLzNo5USU6JRWK=
HSC-2 MnTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTJwMUK4PVgh|ryP M2TWXXNCVkeHUh?=
LCLC-97TM1 M1PHR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTJwMUS1PFMh|ryP MUfTRW5ITVJ?
DMS-273 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4m3bWlEPTB;Mj6xOFg{PyEQvF2= NWLKcG8zW0GQR1XS
TE-8 NVzpRYpsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfaTWM2OD1{LkG1O|Y2KM7:TR?= MnS0V2FPT0WU
DSH1 NGniVZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTJwMU[zPVgh|ryP NYLpeG1xW0GQR1XS
CAL-51 M3HDZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vpSWlEPTB;Mj6xOlY6QSEQvF2= MULTRW5ITVJ?
IST-SL1 MnP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPQVGpFUUN3ME2yMlE3QDR2IN88US=> MnjlV2FPT0WU
GCT MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnz3TWM2OD1{LkG3O|ch|ryP MmnZV2FPT0WU
SW948 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTJwMUi0OVYh|ryP MmnpV2FPT0WU
NOMO-1 NFXFPXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LjS2lEPTB;Mj6xPVMyPyEQvF2= M3vrd3NCVkeHUh?=
C8166 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TKcmlEPTB;Mj6yNVM{PCEQvF2= MmrWV2FPT0WU
OC-314 M2PMdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTJwMkOyOVkh|ryP M2DBd3NCVkeHUh?=
CAL-39 M1jOUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2C0fGlEPTB;Mj6yN|YzPiEQvF2= M2G5WHNCVkeHUh?=
MDA-MB-453 M1vT[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTJwMkSyO|Uh|ryP NVK1[HpEW0GQR1XS
A673 NHL2PJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrNdmR[UUN3ME2yMlI2QDZ{IN88US=> MWfTRW5ITVJ?
HTC-C3 Moi5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mln3TWM2OD1{LkK2PFUh|ryP NWHvcHZRW0GQR1XS
NCI-H1666 NGrqUpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYCzeIU2UUN3ME2yMlI5OTFzIN88US=> MnvxV2FPT0WU
PSN1 NXO5PWNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PCemlEPTB;Mj6yPFkyOyEQvF2= MVnTRW5ITVJ?
GI-1 MoLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjLeJNHUUN3ME2yMlMxPTR|IN88US=> NXLBNYwxW0GQR1XS
HuH-7 MlzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlK4TWM2OD1{LkOwOlM4KM7:TR?= M2rubHNCVkeHUh?=
JAR MlnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlG3TWM2OD1{LkOxPVg4KM7:TR?= NH;IXIFUSU6JRWK=
5637 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfydYFKUUN3ME2yMlMzOTJ7IN88US=> NWTvbFZyW0GQR1XS
GB-1 NIn2[GJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkH6TWM2OD1{LkOyN|M2KM7:TR?= NInOcGVUSU6JRWK=
KP-N-YS NYTkSVZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrhTHFKSzVyPUKuN|I3OTVizszN M4fUS3NCVkeHUh?=
OAW-42 NH;SWFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTJwM{O0NVYh|ryP NVPG[3BsW0GQR1XS
8-MG-BA M{XUNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkn1TWM2OD1{LkOzPVA3KM7:TR?= M4iwcnNCVkeHUh?=
RH-18 NYPFd4g1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTJwM{WwNlIh|ryP Mm[1V2FPT0WU
NCI-H1155 NVexRYFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTJwM{[3NlUh|ryP M4CyUHNCVkeHUh?=
NB17 NE\UV5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;ETWM2OD1{LkO4NlQ{KM7:TR?= MVnTRW5ITVJ?
NCI-H1437 M{XEPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XWR2lEPTB;Mj60NVg4OyEQvF2= NXTRV454W0GQR1XS
SN12C MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTJwNEOyNVQh|ryP NWTXeYdxW0GQR1XS
HSC-3 MmLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXKTWM2OD1{LkS0OVA6KM7:TR?= MnO4V2FPT0WU
GAMG MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7hWXZVUUN3ME2yMlQ1PTZzIN88US=> Mm\0V2FPT0WU
HT-1080 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfOcm9KSzVyPUKuOFQ5PjRizszN NWXESWRxW0GQR1XS
A549 MoftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTJwNES4PVMh|ryP M2PZc3NCVkeHUh?=
KNS-62 M3r1dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfjTWM2OD1{LkS1NFYyKM7:TR?= NHzLeIVUSU6JRWK=
YKG-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLZTWM2OD1{LkS1OFM4KM7:TR?= NH7iS2dUSU6JRWK=
LU-134-A NG\mepVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofoTWM2OD1{LkS3NFA5KM7:TR?= M3L6SXNCVkeHUh?=
FADU NHrQO|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVK2SlR1UUN3ME2yMlQ4OTZ{IN88US=> M{XhcXNCVkeHUh?=
TGBC11TKB NUTHOYx1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3X6PWlEPTB;Mj60O|E4PyEQvF2= NF3qUYxUSU6JRWK=
HT-3 NFXPNGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHETpBTUUN3ME2yMlQ6PTN3IN88US=> MmPPV2FPT0WU
NCI-H2170 NYnGdWlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3P5[GlEPTB;Mj61NFU1QSEQvF2= NVLnTZZ{W0GQR1XS
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SK-MEL-28 M2Lzc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTFyLkCxPVMh|ryP MVHTRW5ITVJ?
NCI-H2452 MlHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXsNGpSUUN3ME2xNE4yPiEQvF2= MX;TRW5ITVJ?
NCI-H1395 M1nqO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXjWYVTUUN3ME2xNE4yPzhizszN NVewfFRNW0GQR1XS
NCI-H2052 MmW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlSwTWM2OD1zMD6xPFgzKM7:TR?= NYXwZVdbW0GQR1XS
A375 NVTId49HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjwTWM2OD1zMD6yOFUzKM7:TR?= NXzUbms5W0GQR1XS
HCC38 NG\NOphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2i2T2lEPTB;MUCuN|IzKM7:TR?= NV\5emRHW0GQR1XS
LK-2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HMRmlEPTB;MUCuOFIxQCEQvF2= MVfTRW5ITVJ?
SF126 MnPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;vWGNKSzVyPUGwMlQ4OjdizszN NHmyUndUSU6JRWK=
SK-MEL-1 MoDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPsbo1KSzVyPUGwMlc5OzhizszN NXvJNmplW0GQR1XS
ACN MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTFyLki2O|kh|ryP NHK1UnVUSU6JRWK=
BB30-HNC NWewSW4xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPFWY1KSzVyPUGwMlg4OTFizszN MV7TRW5ITVJ?
NCI-H747 NHrrO2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LKfmlEPTB;MUCuPFc1PiEQvF2= M2fYb3NCVkeHUh?=
KYSE-150 NU\xSJltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofBTWM2OD1zMT6wN|g4KM7:TR?= Mlf3V2FPT0WU
D-247MG NYf1WHRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTFzLkGwNFkh|ryP NYXQfYV3W0GQR1XS
BxPC-3 NHnUN4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWezV29OUUN3ME2xNU4{PzR5IN88US=> NVnMW3BKW0GQR1XS
SK-MEL-30 MnHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTFzLkSwO|kh|ryP MU\TRW5ITVJ?
CAS-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVr6TZRxUUN3ME2xNU41OTB7IN88US=> NUnSdIxKW0GQR1XS
no-10 Mn7VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIKxeoNKSzVyPUGyMlEzOTdizszN M3rFT3NCVkeHUh?=
NCI-H2405 NFXheGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnrNoQ3UUN3ME2xNk4zODN4IN88US=> NF;HUWVUSU6JRWK=
KGN MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\GXo9YUUN3ME2xNk4zQTBzIN88US=> M2fiRXNCVkeHUh?=
BB49-HNC NWG1OpI6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\oN4FKSzVyPUGyMlM6PTZizszN NELVbm9USU6JRWK=
NCI-H1693 M2LPWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3STWM2OD1zMj61PFE3KM7:TR?= MkXBV2FPT0WU
RO82-W-1 NH7NdnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXWeYM2UUN3ME2xN{4xPjR7IN88US=> MoDBV2FPT0WU
CAL-85-1 M{n6NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTxWIRnUUN3ME2xN{41Ozl7IN88US=> NWDMUGdmW0GQR1XS
H-EMC-SS M3;zW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTF|LkmxNFQh|ryP NWLjZYdlW0GQR1XS
SW1783 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXe0Zmt7UUN3ME2xOE4zOzlzIN88US=> NGW2WlhUSU6JRWK=
LB771-HNC NYqwU|dET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEToPGRKSzVyPUG0MlQyQSEQvF2= Mn\WV2FPT0WU
HCC70 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\tTWM2OD1zND60NlM{KM7:TR?= NV7WSWZ1W0GQR1XS
KNS-81-FD NULDdo1bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTF2LkewOFUh|ryP MX\TRW5ITVJ?
KYSE-520 MlXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXsU|l1UUN3ME2xOE46OjdizszN Mn3KV2FPT0WU
TGBC24TKB MkL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nCRmlEPTB;MUSuPVU{QSEQvF2= MX3TRW5ITVJ?
SNB75 M1\pR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfWOY9EUUN3ME2xOU4xPzJ7IN88US=> NV\z[GFqW0GQR1XS
SW872 M1fhfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnJbFIxUUN3ME2xOU4zOjF6IN88US=> MlPWV2FPT0WU
U031 M1nUW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3m5VmlEPTB;MUWuPFAzQCEQvF2= MWLTRW5ITVJ?
ChaGo-K-1 Ml;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vBWmlEPTB;MUWuPFM2QSEQvF2= MXzTRW5ITVJ?
NCI-H441 NX2xb3dKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3m5dGlEPTB;MU[uNFA{QSEQvF2= M4LPfHNCVkeHUh?=
TE-12 NWHJOWhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGD4SGVKSzVyPUG2MlE5PzNizszN MWjTRW5ITVJ?
NCI-H1755 NFniWo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXBVIdKSzVyPUG2MlU4OyEQvF2= MW\TRW5ITVJ?
KNS-42 M33hNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3STWM2OD1zNj62OVg6KM7:TR?= MojYV2FPT0WU
SK-PN-DW M1rvemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTF5LkSyNFEh|ryP MkfOV2FPT0WU
NCI-H226 MmjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HoZ2lEPTB;MUeuPVM1PSEQvF2= M3rpb3NCVkeHUh?=
K-562 M3;uVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3y4UmlEPTB;MUiuOlMyPyEQvF2= M{i3bnNCVkeHUh?=
A388 NXj4VXNrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;2UlI5UUN3ME2xPU4xOzB|IN88US=> Mn\aV2FPT0WU
ZR-75-30 MmW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFKwUIZKSzVyPUG5MlA6PjhizszN M4DJdXNCVkeHUh?=
LU-135 NV\PVHY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTF7LkK2N|Yh|ryP MXnTRW5ITVJ?
NCI-H2029 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrxOIZKSzVyPUG5MlYxOjFizszN MoPOV2FPT0WU
HT-1197 M175VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jrRWlEPTB;MUmuPVIzPyEQvF2= NF[1cWdUSU6JRWK=
IGR-1 M13Rcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTJyLkOxNVch|ryP MUDTRW5ITVJ?
U-87-MG NUHCUok1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH2yUJNKSzVyPUKwMlY1OTNizszN NEPSeGxUSU6JRWK=
NCI-H1304 M3KxUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTJyLke1NFEh|ryP NYPCUFRrW0GQR1XS
RCC10RGB M4mwT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUWyXlRQUUN3ME2yNU4zQDJ7IN88US=> M4TjNXNCVkeHUh?=
NCI-H520 MmHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zJcGlEPTB;MkKuO|YyOSEQvF2= MWPTRW5ITVJ?
SK-LU-1 NVHZelR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nQbWlEPTB;MkOuNFcyQCEQvF2= MV;TRW5ITVJ?
UACC-893 NHjVWGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zUNmlEPTB;MkOuNVA{QCEQvF2= MV7TRW5ITVJ?
NCI-H2347 NH\FTndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;ubGlEPTB;MkOuNlY4PCEQvF2= MnXvV2FPT0WU
U-118-MG NWP4Nmo6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\KR2lEPTB;MkOuO|IyPyEQvF2= NE\aUWZUSU6JRWK=
NCI-H596 M{PUS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LuTmlEPTB;MkOuPVA2PSEQvF2= MV\TRW5ITVJ?
MZ1-PC M335NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTJ2Lk[3OVkh|ryP M3KzOHNCVkeHUh?=
SW1417 M2\afWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\NTWM2OD1{NT6yOFk5KM7:TR?= MWjTRW5ITVJ?
NCI-H82 NIfpbIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3VTWM2OD1{Nj60Nlg5KM7:TR?= NXHp[oJ6W0GQR1XS
COLO-678 NXW2ZVZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTo[nZKSzVyPUK3MlQ6OTlizszN MUfTRW5ITVJ?
KURAMOCHI NEnhSYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTJ6LkGyOkDPxE1? NXLnSlBJW0GQR1XS
NCI-H1650 M4OwZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fkOmlEPTB;M{CuNVkzPCEQvF2= M1PGbHNCVkeHUh?=
HCC1954 NV[5PFBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTNzLkO2OlYh|ryP MXXTRW5ITVJ?
GAK M3uzZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXKTWZKSzVyPUOyMlI3OTZizszN MkCxV2FPT0WU
YAPC NYC0THY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTN|Lke2OFgh|ryP M1jkSXNCVkeHUh?=
NCI-H2228 MnfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zCVWlEPTB;M{SuN|YxPSEQvF2= MY\TRW5ITVJ?
VMRC-RCZ NHvmblBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHG3UJNKSzVyPUO2MlMxOjJizszN M1;YNnNCVkeHUh?=
NMC-G1 MnHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjYUItKSzVyPUO3MlA2OjlizszN M4fIU3NCVkeHUh?=
D-336MG MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzIT3JHUUN3ME20NU45PDR{IN88US=> M1jTeXNCVkeHUh?=
UACC-62 M{TYbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkT0TWM2OD12Mj61OVA2KM7:TR?= MlHqV2FPT0WU
C-33-A MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHsZ4VKSzVyPUS1MlMzPTZizszN NWDJeVM1W0GQR1XS
HCC1937 NWTJPI4yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jDd2lEPTB;NEeuNVk2QCEQvF2= NFqxcHpUSU6JRWK=
HDLM-2 NFLaeJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\5NlhCUUN3ME20O{4zOjh5IN88US=> MWPTRW5ITVJ?
NCI-H727 MnrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1KzS2lEPTB;NEeuNlQ2OSEQvF2= MnPFV2FPT0WU
NY MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTFTWM2OD12OT6zPVA5KM7:TR?= NX7nellYW0GQR1XS
NCI-H2291 M{C5OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\0d2lEPTB;NEmuPFMxOSEQvF2= NHyyeJlUSU6JRWK=

多くの細胞株試験データを見る場合、クリックしてください

体内試験 Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

お薦めの試験操作(参考用のみ)

キナーゼ試験:

[1]

+ 展開

Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
細胞試験:

[2]

+ 展開
  • 細胞株: LNCaP, PC-3, and TSU-Pr1
  • 濃度: Dissolved in DMSO, final concentrations ~7.5 μM
  • 反応時間: 1, 2, 3 and 4 days
  • 実験の流れ:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (参考用のみ)
動物試験:

[2]

+ 展開
  • 動物モデル: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • 製剤: Dissolved in DMSO
  • 投薬量: ~100 mg/kg/day
  • 投与方法: Injection i.p.
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
混合させたのち直ちに使用することを推奨します。
5mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 264.3
化学式

C14H20N2O3

CAS No. 149647-78-9
保管
in solvent
別名 SAHA, MK0683, suberoylanilide hydroxamic acid

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01059552 Active, not recruiting Locally Advanced Non-small Cell Lung Cancer Fox Chase Cancer Center|National Comprehensive Cancer Network December 6, 2009 Phase 1
NCT02108002 Enrolling by invitation Von Hippel-Lindau Disease National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) March 5, 2014 Phase 1
NCT03022565 Not yet recruiting Uveal Melanoma Nicolas Acquavella|University of Miami Sylvester Comprehensive Cancer Center|University of Miami April 2017 --
NCT02943642 Not yet recruiting Mycosis Fungoides Angimmune LLC|City of Hope National Medical Center|Columbia University|Dana-Farber Cancer Institute|Feinberg School of Medicine, Northwestern University|H. Lee Moffitt Cancer Center and Research Institute|Ohio State University Comprehensive Cancer Center|Rush University Medical Center|Scott and White Hospital & Clinic|Yale University|Stanford University|Thomas Jefferson University|University of Arkansas|University of Colorado Denver School of Medicine Barbara Davis Center|University of Texas Southwestern Medical Center|University of Washington|Vanderbilt University School of Medicine|Washington University School of Medicine January 2017 Phase 2
NCT02836548 Recruiting Melanoma|Skin Neoplasms The Netherlands Cancer Institute June 2016 Phase 1|Phase 2
NCT02589145 Recruiting Lymphoma M.D. Anderson Cancer Center|Celgene Corporation June 2016 Phase 1|Phase 2

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

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Tags: Vorinostat (SAHA, MK0683)を買う | Vorinostat (SAHA, MK0683) ic50 | Vorinostat (SAHA, MK0683)供給者 | Vorinostat (SAHA, MK0683)を購入する | Vorinostat (SAHA, MK0683)費用 | Vorinostat (SAHA, MK0683)生産者 | オーダーVorinostat (SAHA, MK0683) | Vorinostat (SAHA, MK0683)化学構造 | Vorinostat (SAHA, MK0683)分子量 | Vorinostat (SAHA, MK0683)代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID