Vorinostat (SAHA, MK0683)

製品コードS1047 別名:SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683)化学構造

分子量(MW):264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA)は一種のHDAC阻害剤で、無細胞試験でIC50値が約10 nMです。

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文献中の使用例(100)

カスタマーフィードバック(20)

  • Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

    D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

製品安全説明書

HDAC阻害剤の選択性比較

生物活性

製品説明 Vorinostat (suberoylanilide hydroxamic acid, SAHA)は一種のHDAC阻害剤で、無細胞試験でIC50値が約10 nMです。
ターゲット
HDAC [1]
(Cell-free assay)
~10 nM
体外試験

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 NF;ZZm5McW6jc3WgRZN{[Xl? MkSwNUBp NIrCcmJFVVOR NUGydHVn[W62aT3ISGFEOSCjY4Tpeol1gSC5aYToJGlEPTBib3[gNE4yOTJizszN NFKyRWoyOTl4MES4PS=>
Friend leukemic cell M1;PTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVS1NEDPxE1? MUe3NkBp NGXvb5hFVVOR NH3Zc2pKSzVyPUCuPVkh|ryP MWmxNlExQTlzMx?=
K562 M4rJbGtqdmG|ZTDBd5NigQ>? NEjRfW83KGh? NV;t[ZBVTE2VTx?= M4DNUmlvcGmkaYTpc44hd2ZiaIXtZY4hcGm|dH;u[UBl\WGlZYT5cIF{\SBqbXn4eJVz\SCxZjDISGFEOSCjbnSgTGRCSzJrIIfpeIghUUN3MDDv[kAxNjBzIN88US=> M4GzTlEzPDF7M{iw
HT1080 Mo\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmOzO|IhcA>? MlvnSG1UVw>? MXjJR|UxRTJwNDFOwG0> MXixNlI4ODF5NR?=
H1299 M2\oUWtqdmG|ZTDBd5NigQ>? NXm4[XR7OjBibXnu NIXNZnVFVVOR NHvNUWVKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhUESDQzDlcpp6dWVid3n0bEBKSzVyIH;mJFAvOTl2IN88US=> NIG5dIQyPDV{MUSyNi=>
H1299 M4PYdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWS3NkBp NH3LbYZFVVOR NYSyTlBMUUN3ME23MlI1KM7:TR?= M370cVE1PTJzNEKy
HeLa M373fGtqdmG|ZTDBd5NigQ>? MYWzNEBucW5? NGfK[mlKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gZYdicW6|dDDobZN1d26nIHTlZYNmfHmuYYPlJJdqfGhiSVO1NEBw\iByLkK4JO69VQ>? MlziNVU3ODN7NEm=
LOX-IMVI M3O3W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYr0UZhMPDhiaB?= MmHQTWM2OD1zLkOg{txO NVHBdlQ1OTV5MUW0O|A>
NCI-H226 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVj3dWk{PDhiaB?= MXXJR|UxRTJwNjFOwG0> MlnQNVU4OTV2N{C=
RXF-631L NGjkXHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHWydFQ1QCCq NV35cnVCUUN3ME2yJO69VQ>? NVnUNpIyOTV5MUW0O|A>
SNB-78 NHvPPJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUG0PEBp NIqyW2lKSzVyPUG2JO69VQ>? M3mzTVE2PzF3NEew
St-4 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;xcZBqPDhiaB?= NFXXO21KSzVyPUWuNkDPxE1? M{HidFE2PzF3NEew
ARP1 NYj6R4hyTnWwY4Tpc44hSXO|YYm= MlTsNkDPxE1? MUC2JIg> M3fKfmlv\HWldHnvckBw\iCSMkHXRWYyKGenbnWg[ZhxemW|c3nvci=> NWXFfIRrOTR5M{S4NFY>
CEM M4HHfGtqdmG|ZTDBd5NigQ>? MXixJIg> MWTEUXNQ NGnkTFZKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuN|Mh|ryP NWmzW2JYOTZ2MkCwOlQ>
HCT15 NVTacZJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;vc|Q5KGh? M1zlemdKPTB;MD64NkDPxE1? Ml3WNVY4OjN{Mke=
NCI-H23 NIrLcVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmn1OFghcA>? MXXHTVUxRTBwOUKg{txO NUTnbmk3OTZ5MkOyNlc>
GM15850 MYfLbY5ie2ViQYPzZZk> M1riVVIvPSEQvF2= NYTDNFZpQTZiaB?= M2\FPWROW09? NFvMUYdKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgNVQh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NWDFd2R{OTZ7MkGzOlc>
GM15850 NF7CeIVMcW6jc3WgRZN{[Xl? MofhNk42KM7:TR?= NUS3WoFpQTZiaB?= MYnEUXNQ MVTJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViNTDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>? M{XNZlE3QTJzM{[3
GM15850 NWWwc2VpU2mwYYPlJGF{e2G7 MlTSNk42KM7:TR?= MXW5OkBp NHTE[odFVVOR Mn3HTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEGyJIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n MVSxOlkzOTN4Nx?=
GM15850 NGT0O5BMcW6jc3WgRZN{[Xl? NHrqPGEzNjVizszN MWG5OkBp NX\ON49UTE2VTx?= NF63[GRKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgPUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NYi4b5JFOTZ7MkGzOlc>
GM15850 NVrSTpV6U2mwYYPlJGF{e2G7 MljBNk42KM7:TR?= NFi2NlQ6PiCq NFLL[WNFVVOR NEe3PVhKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgPEBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= M4TxNVE3QTJzM{[3
GM15850 NXrEW2VnU2mwYYPlJGF{e2G7 MUOyMlUh|ryP NEfiV4s6PiCq MVXEUXNQ MV\Jcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViMU[gZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? M{XWdlE3QTJzM{[3
U937 M1T5UmZ2dmO2aX;uJGF{e2G7 Mm[0OUDPxE1? MV2yOEBp NEThfXpFVVOR MUnD[YxtKGO7Y3zlJIFzemW|dDDifUBi[2O3bYXsZZRqd25iYYSgV{9IOi:PIIDoZZNm NVXMNYFjOTdyMES3NVg>
H661 NV70fZdRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nWc|Q5KGh? M1O1OGlEPTB;MTFOwG0> M4S5bVE4OTV5MEC5
U937 NGPucZVHfW6ldHnvckBCe3OjeR?= MmjEOUDPxE1? NHqzUlAzPCCq NIDONXRFVVOR MnX5TY5kemWjc3WgbY4hcGm|dH;u[UBJOyCjY3X0fYxifGmxbh?= M1f4WlE4PDR5N{Ww
U937 NGPWW3JHfW6ldHnvckBCe3OjeR?= M{HuPVEh|ryP MlTyNlQhcA>? MYLEUXNQ NIDyTW9G\m[nY4Sgc44h[WyyaHGgeJVjfWyrbjDhZ4V1gWyjdHnvci=> MXSxO|Q1Pzd3MB?=
RAW264.7 MU\GeY5kfGmxbjDBd5NigQ>? NIXDW44yOCEQvF2= NXvi[3VGOjSq Mn\ue4F1\XJ? NGTCSIpKdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKFSQRnHsdIhiKHC{b3T1Z5Rqd25id3n0bEBKSzVyIH;mJFAvPzZizszN MYSxO|Q4PzVzOB?=
RAW264.7 MXzGeY5kfGmxbjDBd5NigQ>? NGXZdIoyOCEQvF2= M4C2TFI1cA>? MoP5e4F1\XJ? MYnJcohq[mm2aX;uJI9nKEySUz3zeIlufWyjdHXkJG5QKHC{b3T1Z5Rqd25id3n0bEBKSzVyIH;mJFEvQDhizszN MXGxO|Q4PzVzOB?=
SC9 NEjp[lBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\sRVQ5KGh? MoLETWM2OD1yLk[wOkDPxE1? MVuxO|UxPzJzOR?=
ST14A NEDHUVFHfW6ldHnvckBCe3OjeR?= M{TBN|Uhdk1? NG\HWlA4OiCq Mn\FTY5kemWjc3WgbY4hWkWVVD;OVnNHKG2UTlGg[ZhxemW|c3nvci=> MY[xO|U3PTl7Mx?=
ST14A NUXjTWhITnWwY4Tpc44hSXO|YYm= MWS1JI5O MkfwO|IhcA>? NF7H[IFKdmO{ZXHz[UBqdiCHMl[xJI1TVkFiZYjwdoV{e2mxbh?= NIPqVnkyPzV4NUm5Ny=>
PANC1 NV7IcnN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX6wOHZZOSEQvF2= Ml;5TWM2OD1yLkS1JO69VQ>? NIDjfpgyPzV6OEe0OC=>
PANC1 MYnGeY5kfGmxbjDBd5NigQ>? M1XXXlEh|ryP MUOyOEBp M2DBSGlv[3KnYYPlJIlvKHB{MWfBSlEwS0mSMTDn[Y5mKGW6cILld5Nqd25? MUWxO|U5QDd2NB?=
PANC1 NGHDRXBHfW6ldHnvckBCe3OjeR?= M1HhblEh|ryP MYSyOEBp M{e3ZWlv[3KnYYPlJIlvKHB{N3vpdFEh\2WwZTDlfJBz\XO|aX;u NIX6W|YyPzV6OEe0OC=>
PT45 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PySmlEPTB;NDFOwG0> M2e1dFE4PTh6N{S0
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Human microvascular epithelial cell MWDDfZRwfG:6aXOgRZN{[Xl? M1zQTVUxKM7:TR?= MW[3NkBp NVjMT2pQTE2VTx?= MYfJR|UxRTFwMzFOwG0> M4S4OVE5PDl2NE[z
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HCT116 NFPSPVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfSO|Jp NHHqd4VFVVOR M2O5fWlEPTB;MD6zNUDPxE1? M2DDXlE6ODh2Mkm0
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T24 MoLRT4lv[XOnIFHzd4F6 MnfXN{Bp MUXJcoR2[3Srb36gc4YhcGm|dH;u[UBJOyCjY3X0fYxifGmxbjD3bZRpKEWFNUCgc4YhOC5zMjFOwG0> M4fQNlE6ODh2M{m1
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NCI-H69 M17BN2N6fG:2b4jpZ{BCe3OjeR?= MoS0O|IhcA>? NUDmR2RuTE2VTx?= NHPNXYVKSzVyPUKuNFYh|ryP MmDNNVkxQTN6OES=
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SHSY5Y M1jVVmtqdmG|ZTDBd5NigQ>? M2jxSlExKM7:TR?= MYq0PEBp NHvteWJFVVOR MlLNTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkWg{txO NY\kcJpmOTl|NESxO|U>
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DMS114 M{\4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7GbHY1QCCq MnjPS2k2OD1{Lkmg{txO NYHJd5J7OTl2MUmyNFU>
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CFBE41o- M4HabGtqdmG|ZTDBd5NigQ>? M{jFUFUh|ryP MWW4JIg> MXHEUXNQ MWLJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcHmyZYLhZ4V1gWyjdHnvckBw\iCqaYP0c45mKEh| M2q1OlE6QTZ4N{i5
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CFBE41o- MW\LbY5ie2ViQYPzZZk> M1TYcFEh|ryP M4O2SVEhcA>? NV\6WJhuTE2VTx?= MojYTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIFPGWHIheHKxdHXpckBt\X[nbB?= M2TuSVE6QTZ4N{i5
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HCC827 M33QRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmiwO|IhcA>? M3PuXmlEPTB;MT64JO69VQ>? NGC0cG0zODF2M{e3PC=>
LNCAP NVzw[W9RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVi4[3pyPzJiaB?= NHTrXYxKSzVyPUCuOVgh|ryP NET0d2kzODF2M{e3PC=>
NCI-H2122 M1jNUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjJO|IhcA>? NX;3UFJCUUN3ME23MlUh|ryP MkXzNlAyPDN5N{i=
NCI-H358 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nBfVczKGh? MX\JR|UxRTJwNTFOwG0> NFnGOZIzODF2M{e3PC=>
SCC15 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\TO|IhcA>? NHnEfnJKSzVyPUKuOFkh|ryP NGLQeHgzODF2M{e3PC=>
SCC25 MorkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfHO|IhcA>? M4DHbmlEPTB;MT65N{DPxE1? NWDybnVROjBzNEO3O|g>
SKHEP1 M2DHOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHhO|IhcA>? M2f1PWlEPTB;Mz60OkDPxE1? NWj4d5FYOjBzNEO3O|g>
BJ MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3hNVAxKM7:TR?= Ml:0OFghcA>? M2PldmROW09? M{C0TGdzd3e2aDDpcohq[mm2aX;uJIF1KDBwMEWgeI8hOTByIIXN MXKyNFE1Ozh2MB?=
MUF NWTkWHB3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfNVlB2OTByIN88US=> Ml;4OFghcA>? NGrCV|BFVVOR NWrVR41IT3Kxd4ToJIlvcGmkaYTpc44h[XRiMD6wOUB1dyBzMECgeW0> M3TSdVIxOTR|OESw
Caco-2 M2rLVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3MNVAxKM7:TR?= NYXQTHlLPDiq MnXjSG1UVw>? M2DUTmlEPTB;OD6xJO69VQ>? NYXocFB[OjBzNEO4OFA>
Caco-2 Mn\HT4lv[XOnIFHzd4F6 M3PFOlUh|ryP MWi0JIg> MlrsSG1UVw>? NUe3fZZRUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhcGm|dH;u[UBi[2W2eXzheIlwdiCLQ{WwJI9nKDBwMEO3JO69VQ>? NXrWcFVLOjBzNEO4OFA>
Caco-2 MWDLbY5ie2ViQYPzZZk> MYGwMlMyPiCwTTD0c{A{OS54IN88US=> MofHOEBp NH3wS5lFVVOR MUjFfEB3cX[xIHnubIljcXSrb36gc4YhcHWvYX6gTGRCSzFid3n0bEBKSzVyIH;mJFAvOTF7IN88US=> Mon0NlAyPDN6NEC=
Caco-2 NHjBR|FMcW6jc3WgRZN{[Xl? NFz1T3gxNjNzNjDuUUB1dyB|MT62JO69VQ>? MkHqOEBp NYD5elZCTE2VTx?= M3rjZ2V5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFMzD3bZRpKEmFNUCgc4YhOC5zNEeg{txO MVyyNFE1Ozh2MB?=
Caco-2 MWrLbY5ie2ViQYPzZZk> NEDCdlQ3NjN{IH7NJJRwKDZ|MjFOwG0> M3ToN|QhcA>? NWrDcoFITE2VTx?= NXyyW2x{TXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVO1JJdqfGhiSVO1NEBw\iBzMj62JO69VQ>? M2XtV|IxOTR|OESw
Caco-2 NHjxSI5McW6jc3WgRZN{[Xl? NFy3ZXY3NjN{IH7NJJRwKDZ|MjFOwG0> MV20JIg> NYP2WoF7TE2VTx?= M37scmV5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFNzD3bZRpKEmFNUCgc4YhPDFizszN M1PEblIxOTR|OESw
Caco-2 M3\RfWtqdmG|ZTDBd5NigQ>? Mm\CNE4{OTZibl2geI8hOzFwNjFOwG0> Mle5OEBp M176fWROW09? M33lPWV5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFNh?= NXnzT5RiOjBzNEO4OFA>
HepG2 MVrLbY5ie2ViQYPzZZk> NGrCelc2KM7:TR?= MVm2bC=> MYXEUXNQ NXHHN3ZkUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhcGm|dH;u[UBi[2W2eXzheIlwdg>? MVKyNFE1Ozh2MB?=
HepG2 MnvaT4lv[XOnIFHzd4F6 NHXtfms2KM7:TR?= MoHDOog> M4HSfGROW09? M3Hh[Glv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJIhqe3SxbnWgbJlx\XKjY3X0fYxifGmxbh?= NFX4VHkzODF2M{i0NC=>
HepG2 MlLtT4lv[XOnIFHzd4F6 Mof0OUDPxE1? M2XnZVZp MlTjSG1UVw>? MUXJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDhcJBp[S22dXL1cIlvKGGlZYT5cIF1cW:w NVjG[VJ2OjBzNEO4OFA>
HepG2 NGrpZlBMcW6jc3WgRZN{[Xl? MoLJOUDPxE1? MmH5Oog> NUTL[ndzTE2VTx?= M2rwUmlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJGg{N0h2IHjpd5RwdmViYXPleJlt[XSrb36= NGLCWYYzODF2M{i0NC=>
COLO205 MUjLbY5ie2ViQYPzZZk> M4flclExKM7:TR?= NIq0fFUzPCCq M4DJU2ROW09? MnjCTY5pcWKrdHnvckBw\iCKRFHDNUBie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gbIl{fG:wZTDIN{Bi[2W2eXzheIlwdiC5aYToJGlEPTBib3[gNk4zKM7:TR?= MXSyNFQ2OTN5OB?=
SCC4 NGW5OWJMcW6jc3WgRZN{[Xl? MmLQNUDPxE1? NH2z[3UzPGh? NHLpbGpKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6geJVjfWyrbjDhZ4V1gWyjdHnvci=> MmXXNlA1PTJ{MkW=
SCC4 NWTDOHltU2mwYYPlJGF{e2G7 NVflTJFNOSEQvF2= NEXGRlYzPGh? NV76Vm44UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgZYNmfHmuYYTpc44> MkC3NlA1PTJ{MkW=
SCC4 Mlq2SpVv[3Srb36gRZN{[Xl? NEO2NpQyKM7:TR?= MWG1JI1qdg>? M1XlNWFod26rc4SgZYN1cX[rdImgZZQhXkSUIHHzd4V{e2WmIHHzJIlv\HWldHnvckBw\iCFWWCyOEBo\W6nIHX4dJJme3Orb36= MUeyNFQ2OjJ{NR?=
NB4 Mn62SpVv[3Srb36gRZN{[Xl? MlPFOUDPxE1? MmPsNlQhcA>? NVPiUYpuTE2VTx?= NFzDVGlE\WyuIHP5Z4xmKGG{cnXzeEBie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDhZ4N2dXWuYYTpc44h[XRicILlMWcyKHCqYYPl M1LudlIxPDlzNESw
NB4 MXTLbY5ie2ViQYPzZZk> NYH6d2JJPSEQvF2= M{TRVlI1KGh? NGPIcZNFVVOR M1jvbmlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDhZ4V1gWyjdHWgeJVjfWyrbjDs[ZZmdA>? M4n1O|IxPDlzNESw
NB4 MlLySpVv[3Srb36gRZN{[Xl? NGDhXJA2KM7:TR?= NGHvS2MzPCCq MWLEUXNQ MmXyTY5lfWO2aX;uJI9nKHB{MWfBSlEwS0mSMTDlfJBz\XO|aX;u M3vKfFIxPDlzNESw
NB4 MlX0T4lv[XOnIFHzd4F6 MYK1JO69VQ>? NIXKfm4zPCCq MYHEUXNQ M{Lm[WlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFizJIFk\XS7bHH0bY9v NEez[WEzODR7MUS0NC=>
NUGC3 MmLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnmbHNIUTVyPUKuPVQh|ryP MkW1NlA5PTB7N{G=
A549 MmHESpVv[3Srb36gRZN{[Xl? MVq1JO69VQ>? MUGzJIg> MkDPSG1UVw>? NGm2[oVKdmS3Y4Tpc44hd2ZiYYX0c5Bp[We7IHnuJIh2dWGwIFG1OFkh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iTFOzTWk> M37wNlIxQDV3MkC4
HUT78 M1r0XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVy3NkBp MX\EUXNQ NVXTOZlGT0l3ME2wMlMh|ryP MkHXNlA5QDR{MEi=
U937 NWG4NVROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfEZZk4OiCq NXK1U2NTTE2VTx?= NEPPfGlIUTVyPUCuN|kh|ryP MnPhNlA5QDR{MEi=
A431 MkLDR5l1d3SxeHnjJGF{e2G7 MnHNO|IhcA>? NInzRpFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPDNzIHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGVITlJid3n0bEBKSzVyIH;mJFQvOiEQvF2= NFfxN2IzOTB6ME[yPS=>
A549 MVTDfZRwfG:6aXOgRZN{[Xl? M{faNFczKGh? NIjQdWNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhFSUNid3n0bEBKSzVyIH;mJFEvQCEQvF2= MV:yNVA5ODZ{OR?=
CAL27 NHmwN2REgXSxdH;4bYMhSXO|YYm= NXiyN4l4PzJiaB?= NWfOelM1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS0GOMkegZ4VtdHNib4\ldoV5eHKnc4PpcochTUeIUjD3bZRpKEmFNUCgc4YhOy5{IN88US=> MWGyNVA5ODZ{OR?=
HeLa M{iwU2N6fG:2b4jpZ{BCe3OjeR?= MlzuO|IhcA>? NHfsNGZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhFSUNid3n0bEBKSzVyIH;mJFEvPSEQvF2= NIWwXVQzOTB6ME[yPS=>
Sf21 NVmxXplEU2mwYYPlJGF{e2G7 MVmzJIg> MUTJcohq[mm2aX;uJI9nKE[uYXegeIFo\2WmIHj1cYFvKHKnY3;tZolv[W62IFjERWM5KGW6cILld5Nm\CC5aYToJGlEPTBib3[gNU4zKM7:TR?= NIrTdpkzOTB6ME[yPS=>
SKBR3 M1nrfWN6fG:2b4jpZ{BCe3OjeR?= MXW3NkBp NE\5UJpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0KUMzDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTVJ{IIfpeIghUUN3MDDv[kAzNjZizszN MYGyNVA5ODZ{OR?=
SKOV3 NXTDe49{S3m2b4TvfIlkKEG|c3H5 Ml7CO|IhcA>? Ml6xR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tQXjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiC5aYToJGlEPTBib3[gNk4zKM7:TR?= MX6yNVA5ODZ{OR?=
COR-L23 NGjBRWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInsOYsyOCEQvF2= MVW3NkBp MnqxSG1UVw>? MUXHTVUxRTFwMTFOwG0> MnvnNlExQDB4NEe=
DU145 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3y4[FExKM7:TR?= MnnQO|IhcA>? MnizSG1UVw>? NEjGXVVIUTVyPUGuNFUh|ryP M3rkVFIyODhyNkS3
LoVo MlvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NViy[ldkOTBizszN M4XK[|czKGh? M{\oXmROW09? MXXHTVUxRTFwNzFOwG0> MkLrNlExQDB4NEe=
MCR5-SV2 NIDvZo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnrNVAh|ryP MUS3NkBp MkTNSG1UVw>? M1POPWdKPTB;Mj6xJO69VQ>? M1jIeFIyODhyNkS3
HCT116 MVnLbY5ie2ViQYPzZZk> NU\OVWtxOzBizszN NX3wc4l4OzBiaB?= MVfEUXNQ NEjqOnJKdmirYnn0bY9vKG:oIFjERWM3KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBidHCqYT30eYJ2dGmwIHHj[ZR6dGG2aX;u Mn3MNlExQDB4NEe=
HCT116 NXHOSJd4U2mwYYPlJGF{e2G7 M4LSSFMxKM7:TR?= Mk\qN|AhcA>? MYjEUXNQ MYHJcohq[mm2aX;uJI9nKEiGQVOxJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDobZN1d26nIFizT|kh[WOndInsZZRqd25? NF7wRlEzOTB6ME[0Oy=>
U937 MVjLbY5ie2ViQYPzZZk> NIfqbZo2KM7:TR?= NGf3T2EzPCCq MlvpSG1UVw>? NXXOcppiUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{m= M1nhOFIyOjl{NEmy
U937 M3PUcWtqdmG|ZTDBd5NigQ>? MVm1JO69VQ>? MlrWNlQhcA>? MXTEUXNQ NEHwXWVKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4Yh[WOndInsZZRqd25ib3[gbIl{fG:wZTDIN{BifCCNMUi= NX7y[Hl2OjF{OUK0PVI>
U937 NUTSfldtU2mwYYPlJGF{e2G7 NVTUVodmPSEQvF2= MVuyOEBp MmewSG1UVw>? MXHJcohq[mm2aX;uJI9nKGirc4TvcoUh[WOndInseJJidnOoZYLhd4Uh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[gdIFvNWGlZYT5cIF1\WRiaHnzeI9v\SCKNDDs[ZZmdA>? MXmyNVI6OjR7Mh?=
U937 NUKwcHZYU2mwYYPlJGF{e2G7 NEXkc442KM7:TR?= NH7WepcyPSCvaX6= NF21OY5FVVOR NUDGcG9QUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGirc4TvcoUhUDNiYXPleJlt[XSrb36gcIV3\Wx? NV\McZJmOjF{OUK0PVI>
A2780 Mn;aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3rPVYhcA>? NGfGXJBFVVOR NEnDXZRKSzVyPUGuOlIh|ryP NGT4N2czOTZ|NESzNC=>
COLO205 MnzoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PSU|k3KGh? MXvEUXNQ MkfUTWM2OD1{LkGyJO69VQ>? NFnQcpIzOTZ|NESzNC=>
Hep3B NIfDVWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37Id|Q5KGh? NY\zUoRETE2VTx?= M{L3emdKPTB;MT6yNUDPxE1? MY[yNVcyOjF2Nh?=
GM11272 NE\oS2FHfW6ldHnvckBCe3OjeR?= MkjmNVAxKG6P NHLheGk4OiCq M{\DW2ROW09? M1zXNHJm[WO2aY\heIlwdiCxZjDN[WNxOiCvdYThcpQh\XiycnXzd4lwdiCjdDCxNEB1dyBzMECgcm0> Mn;ZNlE5PDB5MU[=
CFBE41o NWXhUnJoU2mwYYPlJGF{e2G7 NEPzUlY2KM7:TR?= MkjiSG1UVw>? M2Li[mRwf25icnXneYxifGmxbjDv[kBJTEGFNzDheEAxNjJidH:gOUB2VQ>? M{HMTFIyQTh2OUW4
CFBE41o MlKwSpVv[3Srb36gRZN{[Xl? NVPCN2VQOSEQvF2= NG\IWpYzPCCq MUXEUXNQ NFX0PHhT\XO2b4LheIlwdiCxZjDDSnRTKGSnbIThSlUxQCCvdYThcpQhfHKjZn\pZ4tqdmdidH:gZ4VtdCC|dYLmZYNmKGG|IHfsfYNw\m:{bYO= MXeyNVk5PDl3OB?=
DU145 MkfrT4lv[XOnIFHzd4F6 MUeyMlUh|ryP NV\JbYRWOjRiaB?= NIDGbVlFVVOR MmOwTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KHWycnXneYxifGmxbjDv[kBxOjG5YX[xJJBzd3SnaX6g[ZhxemW|c3nvci=> NGi3WWozOjJ4MEG2Oi=>
DU145 NEKzZ5VMcW6jc3WgRZN{[Xl? MWS1JO69VQ>? NFf2SGkzPCCq NV;Pdm5TTE2VTx?= MX7Jcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcGm|dH;u[UBJPCCjY3X0fYxifGmxbh?= M2HZSVIzOjZyMU[2
DU145 NFTVUpZMcW6jc3WgRZN{[Xl? MUS1JO69VQ>? NIn0Z2szPCCq MkX6SG1UVw>? MUXJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcGm|dH;u[UBJOyCqeYDldoFk\XS7bHH0bY9v M4e0bFIzOjZyMU[2
786-0 NXfkVIRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzGfZBsPi5{IN88US=> M1jaTFczKGh? M4POTGROW09? MnvDS2k2OD1|LkKg{txO NGfETWYzOjR|NU[2PS=>
A498 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\NOk4zKM7:TR?= MVy3NkBp NUjROZhTTE2VTx?= NVfKemlnT0l3ME2xMlYh|ryP M1nKdVIzPDN3Nk[5
A549/ATCC NHuyZWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHWS5dKPi5{IN88US=> NUX2NZE3PzJiaB?= NWnNdYRnTE2VTx?= MYXHTVUxRTFwNjFOwG0> M4rYUVIzPDN3Nk[5
ACHN NInpdndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXO2MlIh|ryP NEHGeGc4OiCq M2\yPGROW09? M13Gd2dKPTB;MT6zJO69VQ>? NW\FZnlQOjJ2M{W2Olk>
BT549 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHCOk4zKM7:TR?= NF;OS4Y4OiCq NI\i[FJFVVOR M4j1XWdKPTB;MT6zJO69VQ>? NYrHT2VmOjJ2M{W2Olk>
EKVX Ml7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXe2MlIh|ryP NXL2R4ZCPzJiaB?= NHXoR2pFVVOR NFvIR4dIUTVyPUGuN{DPxE1? M2HmPVIzPDN3Nk[5
HCT15 NFf6Z2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPUOk4zKM7:TR?= NH7LbYE4OiCq NWDpd5RTTE2VTx?= MULHTVUxRTJwNTFOwG0> MUWyNlQ{PTZ4OR?=
HOP92 M2K3XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnu3Ok4zKM7:TR?= NUL4Tm5YPzJiaB?= M1TPfWROW09? NEK3eHpIUTVyPUSg{txO M4\tSVIzPDN3Nk[5
IGROV1 NFfpc|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml20Ok4zKM7:TR?= Mny4O|IhcA>? NILycJFFVVOR NH22bFhIUTVyPUGuN{DPxE1? M{Ltd|IzPDN3Nk[5
LOXIMVI MlLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTQOk4zKM7:TR?= NGS5N4I4OiCq NH;L[lRFVVOR MX7HTVUxRTFizszN MlvWNlI1OzV4Nkm=
M14 NIHHVHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWryeotlPi5{IN88US=> MXG3NkBp M1TBRmROW09? M3X0ZWdKPTB;MT6zJO69VQ>? MV6yNlQ{PTZ4OR?=
MALME-3M MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3JOk4zKM7:TR?= NFKwb5E4OiCq M4rlZmROW09? MUPHTVUxRTBwM{Kg{txO M3r0W|IzPDN3Nk[5
MCF10A MlfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TaZVYvOiEQvF2= M3[0XlQ5KGh? M3raVGROW09? M4PHNGdKPTB;OT62JO69VQ>? NEfrOmIzOjR|NU[2PS=>
MDA-MB-435 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrUSoF1Pi5{IN88US=> MljRO|IhcA>? M2fHPGROW09? MVjHTVUxRTBwNTFOwG0> NXTDS5hVOjJ2M{W2Olk>
MDA-MB-468 NIXaZ5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\jVXp7Pi5{IN88US=> MWe3NkBp MVTEUXNQ NFraNIVIUTVyPUCuOlMh|ryP NGHjUGEzOjR|NU[2PS=>
MOLT4 M3vxZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXj[Xo3NjJizszN NX;6S|JwPzJiaB?= M1rnO2ROW09? M1zTbmdKPTB;MD60JO69VQ>? M17DXlIzPDN3Nk[5
NCI-ADR-RES MkHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPiZ|JSPi5{IN88US=> NFjvRpM4OiCq NEDkWW5FVVOR MVnHTVUxRTBwMU[g{txO NWTzflJPOjJ2M{W2Olk>
NCI-H23 M4\OcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWD5dJRlPi5{IN88US=> NVG0UZpnPzJiaB?= M{nR[WROW09? NGPrVnlIUTVyPUGg{txO NYLCZW9JOjJ2M{W2Olk>
NCI-H322M MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYO2MlIh|ryP NUHyOIk2PzJiaB?= NWTJUFZLTE2VTx?= NGHTPW1IUTVyPUCuO|kh|ryP M1;kRlIzPDN3Nk[5
NCI-H460 MlzlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\wZZo{Pi5{IN88US=> Mn\UO|IhcA>? NWHoZ|k2TE2VTx?= M{LvRmdKPTB;MD63PUDPxE1? MmnONlI1OzV4Nkm=
NCI-H522 NF7vW4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvh[HY3NjJizszN NUnJPWJVPzJiaB?= MmH0SG1UVw>? NYTROXZTT0l3ME2wMlUh|ryP MVuyNlQ{PTZ4OR?=
OVCAR3 NYnRdFIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXyyWJZbPi5{IN88US=> NEjabI44OiCq MlT1SG1UVw>? MX\HTVUxRTFwMzFOwG0> MWGyNlQ{PTZ4OR?=
OVCAR4 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXae|NJPi5{IN88US=> MlHRO|IhcA>? NWHNPHNCTE2VTx?= MmjzS2k2OD12IN88US=> MX:yNlQ{PTZ4OR?=
OVCAR5 MnLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX:4ZndUPi5{IN88US=> MYi3NkBp MmHGSG1UVw>? M4jCPWdKPTB;MD63PUDPxE1? MUOyNlQ{PTZ4OR?=
OVCAR8 NYLZdJZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXxOndXPi5{IN88US=> NELGS2c4OiCq NGPqS3lFVVOR NH6wSHZIUTVyPUCuOUDPxE1? NYT6UIl5OjJ2M{W2Olk>
RXF393 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYm1ZVB{Pi5{IN88US=> M4LzPVczKGh? MXfEUXNQ NEHKUpZIUTVyPUGuN{DPxE1? NWP5SoxzOjJ2M{W2Olk>
SF268 M{DMcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoX4Ok4zKM7:TR?= NW[wbZUxPzJiaB?= MXzEUXNQ NWDD[2VOT0l3ME2xMlYh|ryP M2HjN|IzPDN3Nk[5
SF295 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUiyNGhwPi5{IN88US=> NGTRb2I4OiCq NVvlPJJLTE2VTx?= NFfYN2FIUTVyPUGuOkDPxE1? NH\xeG8zOjR|NU[2PS=>
SF539 NVrYXFhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3IR4E3NjJizszN MW[3NkBp MYTEUXNQ MlLpS2k2OD1{IN88US=> M4XucVIzPDN3Nk[5
SK-MEL-2 M{TlWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HCTFYvOiEQvF2= NF73NpQ4OiCq NXG4PWFFTE2VTx?= M2XJSGdKPTB;MT6zJO69VQ>? NHfRd44zOjR|NU[2PS=>
SK-MEL-28 NYrWZVBPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjtOk4zKM7:TR?= NH7wVmQ4OiCq M3;Lb2ROW09? NGD4flNIUTVyPUGg{txO MorxNlI1OzV4Nkm=
SK-MEL-5 MlTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrSWnk3NjJizszN NVr2endTPzJiaB?= MU\EUXNQ M2jmNmdKPTB;MD62N{DPxE1? M4nZR|IzPDN3Nk[5
SKOV3 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDuOXo3NjJizszN NHXa[lc4OiCq MVPEUXNQ M1T4dWdKPTB;MTFOwG0> MYqyNlQ{PTZ4OR?=
SN12C NUTweZN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUO2MlIh|ryP MV:3NkBp M4XG[2ROW09? NUG1UWdzT0l3ME2yJO69VQ>? MXmyNlQ{PTZ4OR?=
SNB19 NGPOXYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moq1Ok4zKM7:TR?= MmDxO|IhcA>? M3XpRWROW09? NGDuZmZIUTVyPUCuOlMh|ryP MYCyNlQ{PTZ4OR?=
SNB75 M{fP[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFG0VWg3NjJizszN MkH3O|IhcA>? MY\EUXNQ M2Hw[WdKPTB;MD63PUDPxE1? M3ru[VIzPDN3Nk[5
SR MnGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWK2MlIh|ryP NFzrdFk4OiCq MlfPSG1UVw>? NHTyV4xIUTVyPUCuOEDPxE1? MXOyNlQ{PTZ4OR?=
T47D MnHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzYZpRtPi5{IN88US=> M{WwWFczKGh? M4rJc2ROW09? NVXLSmt2T0l3ME2wMlUh|ryP M3;2OFIzPDN3Nk[5
TK10 NVXLVFJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXtUHhiPi5{IN88US=> M{DEb|czKGh? NGfkSnFFVVOR NFPR[3FIUTVyPUCuOlMh|ryP M121V|IzPDN3Nk[5
UACC257 NInCPIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2ixeFYvOiEQvF2= NV\uS257PzJiaB?= M3zaPWROW09? NHnkV|ZIUTVyPUCuOUDPxE1? M4TWT|IzPDN3Nk[5
UACC62 MmTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjGOk4zKM7:TR?= NVX0W2lnPzJiaB?= MU\EUXNQ NVO0SnFuT0l3ME2wMlQh|ryP MUKyNlQ{PTZ4OR?=
UO31 NEXYPWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fDWVYvOiEQvF2= MX63NkBp MoewSG1UVw>? NIfGNGNIUTVyPUCuOUDPxE1? NWLBfVZiOjJ2M{W2Olk>
Hep3B NYiwcGJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\tWFQ5KGh? NHnwZ2ZFVVOR NE\nT3hIUTVyPUCuOlkh|ryP MVKyNlQ{QTh4Mx?=
BE(2)-C M1jsOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljEO|IhcA>? MoLJSG1UVw>? NFzhfJNKSzdyPUKg{txO NWHLVHhtOjJ7M{KzNVY>
Bel7402 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXG3NkBp NUXIdFVGTE2VTx?= M3nJT2dKQTB;MUeg{txO MUCyN|A3OTN5Nh?=
Bel7404 MnrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrFXno4OiCq Mne4SG1UVw>? MXHHTVkxRTF6IN88US=> MUWyN|A3OTN5Nh?=
BGC823 M3jDTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4O4UVczKGh? NXHicWQ5TE2VTx?= M3HoXGdKQTB;Nz61JO69VQ>? NHHNVXEzOzB4MUO3Oi=>
MGC803 NUCxc3dDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrQe455PzJiaB?= NIjXZmpFVVOR NH:2Ro9IUTlyPUGwMlgh|ryP M4TpfVI{ODZzM{e2
SGC7901 MlrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXDSok4OiCq M3;ye2ROW09? M4e4dWdKQTB;OT60JO69VQ>? MWWyN|A3OTN5Nh?=
SKHEP1 M1[wUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUS3NkBp NHfnTG1FVVOR NX\BdJlWT0l7ME2xO{DPxE1? MW[yN|A3OTN5Nh?=
SMMC7721 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfLO|IhcA>? NYTXVJFyTE2VTx?= NWPDdolOT0l7ME2yNEDPxE1? MV2yN|A3OTN5Nh?=
NUGC3 M33JNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVK4eIVjOTBizszN NFvmR45IUT1{Lkm0JO69VQ>? MV2yN|E3OzN|Mh?=
A2780 CisR M{jXTGtqdmG|ZTDBd5NigQ>? MY[xPEBp MV;Jcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNESg{txO NUXENWhLOjN{NUK2NFM>
CAL27 sens MVTLbY5ie2ViQYPzZZk> NFPGXmEyQCCq M33xO2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD6zOkDPxE1? NGX2d4YzOzJ3Mk[wNy=>
CAL27 CisR Mnz1T4lv[XOnIFHzd4F6 MoXVNVghcA>? MmjGTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>? NV\o[YNxOjN{NUK2NFM>
KYSE-510 CisR NFTFOlJMcW6jc3WgRZN{[Xl? NIPu[ZgyQCCq NEe4W2VKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOVkh|ryP NGXXWG4zOzJ3Mk[wNy=>
KYSE-510 sens Ml6wT4lv[XOnIFHzd4F6 MoLnNVghcA>? NFfZ[mlKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuO{DPxE1? NYPUTIRTOjN{NUK2NFM>
MDA-MB-231 sens MlXOT4lv[XOnIFHzd4F6 Mnu0NVghcA>? M2nmdGlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? NX\qXG5TOjN{NUK2NFM>
MDA-MB-231 CisR NGe2NFVMcW6jc3WgRZN{[Xl? NV:zdIo5OThiaB?= NIjqfmNKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOlEh|ryP NGTRWGwzOzJ3Mk[wNy=>
ES2 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfvTGZ5PDhiaB?= M{fjV2ROW09? MUfJR|UxRTF{Lkeg{txO MkPVNlM1QTN2NEm=
MDA-MB-231 NXrpc49CU2mwYYPlJGF{e2G7 NV\3NZpMOTBizszN M3LXOlMxKG2rbh?= MlrzSG1UVw>? MnnQTY5pcWKrdHnvckBw\iCKRFHDNoE> NWXMOZpIOjN2OUO0OFk>
MDA-MB-231 NVHsWYQ3U2mwYYPlJGF{e2G7 M2e5[lEh|ryP M1PnSlI1KGh? NVPldWk6TE2VTx?= MkHDTY5pcWKrdHnvckBw\iCKRFHDOkBie3Onc4Pl[EBieyCjY3X0fYxifGmxbjDs[ZZmdHNib3[geJVjfWyrbh?= NYKzcG9TOjN2OUO0OFk>
HS68 MmPIR5l1d3SxeHnjJGF{e2G7 MXixNEDPxE1? NXuzOJA1PzJiaB?= M{TVZWROW09? M3LodGlEPTB;ND62JO69VQ>? NHfrWFgzOzV5MEW0Ni=>
MEF MY\DfZRwfG:6aXOgRZN{[Xl? NUTJ[|FWOTBizszN M3XnVlczKGh? M3HOXWROW09? MnzlTWM2OD12LkSg{txO MYCyN|U4ODV2Mh?=
BGC823 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XRdGROW09? M2m5[WdKPTB;Mz6wPUDPxE1? NGPnVYwzOzZyMUewOi=>
High5 MUTLbY5ie2ViQYPzZZk> MXiyOEBp NXXGfo1uUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEPiC5aYToJGlEPTBib3[gNE4xQSEQvF2= NWTRSGpjOjN4MEK1NlM>
High5 MmXKT4lv[XOnIFHzd4F6 MkLtNlQhcA>? MoLrTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCKRFHDNUB4cXSqIFnDOVAhd2ZiMD6xNkDPxE1? NYPFXoQ1OjN4MEK1NlM>
High5 MoWyT4lv[XOnIFHzd4F6 NYDPdFk5OjRiaB?= M3vYVmlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSFTBR|Mhf2m2aDDJR|UxKG:oIECuNVch|ryP NFjaem4zOzZyMkWyNy=>
A549 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnyxSG1UVw>? MXXJR|UxRTFwMEe5JO69VQ>? MUiyN|Y1PDJzMB?=
HCT116 NU[5fFVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXP[5ZFVVOR NFmxcotKSzVyPUCuO|U4KM7:TR?= MVKyN|Y1PDJzMB?=
K562 NIf5UWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXGd4RzTE2VTx?= NVzrSpNLUUN3ME2wMlY1PSEQvF2= MoT4NlM3PDR{MUC=
GBC-SD MlqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1v2RlUh|ryP NGPWRlk4OiCq NHHVdphFVVOR NI\x[nBKSzVyPUG0Mlgh|ryP NFXSWnkzOzdyN{K2NC=>
HGC27 MoS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHu4Z282KM7:TR?= NVn0ZXFEPzJiaB?= M{XSUGROW09? MWjJR|UxRTVwNDFOwG0> NIPqXHkzOzdyN{K2NC=>
HL60 NXv4bHpDU2mwYYPlJGF{e2G7 MV:1JO69VQ>? MXSyOEBp MY\EUXNQ M{PWWGlvcGmkaYTpc44hd2ZiSFTBRy=> NX3oVXNtOjN5MEeyOlA>
Vero MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLPVmlsPzJiaB?= MkHKSG1UVw>? NIfOWmZKSzVyPUCuPUDPxE1? NXPmWXdnOjN5OE[0OVI>
NCI60 NYXqSJAzS3m2b4TvfIlkKEG|c3H5 Moi0OFghcA>? M{TiUWROW09? M2H4fWdKRTBwNUOg{txO MUCyOFAyPTN{Nx?=
SW620 NUDsWlRSS3m2b4TvfIlkKEG|c3H5 MknaOFghcA>? NVfBRpVmTE2VTx?= M4nhPWdKRTBwNUSg{txO MViyOFAyPTN{Nx?=
U251 NHO4SY1EgXSxdH;4bYMhSXO|YYm= MWW0PEBp NGXGbZBFVVOR NF;S[3JIUT1zLkWzJO69VQ>? NXvOUHdQOjRyMUWzNlc>
KM12 NIXuOXlEgXSxdH;4bYMhSXO|YYm= MWO0PEBp MYrEUXNQ MUnHTV0yNjh6IN88US=> MofONlQxOTV|Mke=
Hs578T NFPhfWlEgXSxdH;4bYMhSXO|YYm= MUe0PEBp MkP1SG1UVw>? NVPHV5F2T0l;ND64N{DPxE1? M1;ZUVI1ODF3M{K3
MDA-MB-231 M4nTSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjiZpE1QCCq MmfMTWM2OD1yLkG2JO69VQ>? M3rRd|I1ODl3MEG2
MCF7 M{L0fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nrTFQ5KGh? NWfjZYhlT0l;MD60OUDPxE1? NVTOXmxHOjRzMUm1OVU>
MDA-MB-435 M1PmVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYWyXVQ{PDhiaB?= M1nvN2dKRTBwOEig{txO MVyyOFEyQTV3NR?=
AsPC1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jQXFMxKM7:TR?= M3HvPVQ5KGh? M2q1dmROW09? NUDrV3lOUUN3ME2zMlY3KM7:TR?= M4XHU|I1OTh3M{e4
Jurkat E6.1 MWnLbY5ie2ViQYPzZZk> M1[4OFIhcA>? MUTEUXNQ NXu0PFU{UW6qaXLpeIlwdiCxZjDISGFEPCC5aYToJGlEPTBib3[gNE4xPCEQvF2= M2Xy[lI1OjZzOE[y
KG1 M124WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33rTVQ5KGh? NFi4dJNKSzVyPUGuNVUh|ryP Mlu2NlQ2OjVyMEO=
HEL NUHIS4NoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1mzflQ5KGh? MXrEUXNQ NVrJbWF6UUN3ME2wMlQ6KM7:TR?= NE[zd3YzPDZ7NEC1OS=>
HSC3 M{jJTWN6fG:2b4jpZ{BCe3OjeR?= M2TYWFEzKGh? MUTEUXNQ MYDJR|UxRTBwN{Gg{txO MYKyOFc3PjV4MB?=
HT-29 MnzpR5l1d3SxeHnjJGF{e2G7 MlzlNVIhcA>? NX3ZdmlkTE2VTx?= NVLaeJNbUUN3ME2wMlczKM7:TR?= NW\acJVNOjR5Nk[1OlA>
KB MoLnR5l1d3SxeHnjJGF{e2G7 NILzNpoyOiCq M2PYdWROW09? NFruZldKSzVyPUCuO|Uh|ryP NGTJWYQzPDd4NkW2NC=>
H460 M1nyWWN6fG:2b4jpZ{BCe3OjeR?= MVWxNkBp NGTUd3FFVVOR NEPQWWFKSzVyPUCuPFIh|ryP MoXvNlQ4PjZ3NkC=
MONE1 MVXDfZRwfG:6aXOgRZN{[Xl? NWCzXWRKOTJiaB?= M3TsRmROW09? MnG0TWM2OD1zLkG4JO69VQ>? M{\wNVI1PzZ4NU[w
MKN45 MlTJR5l1d3SxeHnjJGF{e2G7 NFnwdoEyOiCq M3rZTWROW09? M4DCRmlEPTB;MT6yOUDPxE1? M4PlUVI1PzZ4NU[w
TSGH M4PQdmN6fG:2b4jpZ{BCe3OjeR?= MXOxNkBp NHzUdldFVVOR NGfDfnBKSzVyPUKuNFkh|ryP MYWyOFc3PjV4MB?=
HL60 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvwc4M4OiCq NYnWdmZxTE2VTx?= NGe4T4xIUTVyPUCuPVMh|ryP NUTreHAzOjR7MEC1NFA>
HEK293 NIPZb4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfzO|IhcA>? M4LTWmROW09? NHK3U3VIUTVyPUGzJO69VQ>? MV[yOFkxODVyMB?=
Jurkat MlzMR5l1d3SxeHnjJGF{e2G7 M3;iV|ExOCEQvF2= MkfOO|IhcA>? NE\Eb4tIUTVyPUCuPUDPxE1? MmW2NlQ6ODB5NEO=
GM15850 M4HWbWtqdmG|ZTDBd5NigQ>? NUPwV|N7Oi53IN88US=> MUS5OkBp NXnoN3F1TE2VTx?= MmTi[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFE1KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l M13wNlE3QTJzM{[3
GM15850 M3\XSGtqdmG|ZTDBd5NigQ>? MoDhNk42KM7:TR?= M3:3OVk3KGh? NWP0O5VWTE2VTx?= NITjbXRld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJPCCueYPpcoUhPSCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> NXvHdJBWOTZ7MkGzOlc>
GM15850 M4XqdmtqdmG|ZTDBd5NigQ>? MW[yMlUh|ryP NGmxToI6PiCq NYnwcYNkTE2VTx?= MlHl[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFEzKGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l M1PGeFE3QTJzM{[3
GM15850 M{C4VGtqdmG|ZTDBd5NigQ>? NV;mS2R1Oi53IN88US=> NV[1PVN5QTZiaB?= M{nlb2ROW09? M{m5cYRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg{KGy7c3nu[UA6KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NUToWJlrOTZ7MkGzOlc>
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NCI-H1770 M{fSPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfJWphxUUN3ME2xMlQ5PTN4IN88US=> M3zhNXNCVkeHUh?=
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LB2241-RCC NU\KUZdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;TdmlEPTB;MT65PFI{OSEQvF2= NH64WnZUSU6JRWK=
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TE-8 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\TWJRQUUN3ME2yMlE2PzZ3IN88US=> MoPNV2FPT0WU
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C8166 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfNPVBIUUN3ME2yMlIyOzN2IN88US=> MoPFV2FPT0WU
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CAL-39 NV\wRoRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{[yfWlEPTB;Mj6yN|YzPiEQvF2= NXXMWmhQW0GQR1XS
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8-MG-BA NH:5XWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvuPYttUUN3ME2yMlM{QTB4IN88US=> MkjQV2FPT0WU
RH-18 M2i1dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M374bWlEPTB;Mj6zOVAzOiEQvF2= Mn3JV2FPT0WU
NCI-H1155 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TQcWlEPTB;Mj6zOlczPSEQvF2= M4XHUnNCVkeHUh?=
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SN12C MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVj6R2JxUUN3ME2yMlQ{OjF2IN88US=> NYHKc|ZjW0GQR1XS
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HT-1080 MlHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTlTWM2OD1{LkS0PFY1KM7:TR?= M4C3XnNCVkeHUh?=
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MFE-280 NHHUTINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLwTWM2OD17LkeyO|g2KM7:TR?= MnfJV2FPT0WU
BEN MnfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3KwTGlEPTB;OT64NlE2QSEQvF2= NIXC[lVUSU6JRWK=
CP50-MEL-B M3rkVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjmW3RGUUN3ME25MlkzPDN{IN88US=> MkL3V2FPT0WU
SK-MEL-28 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzhTWM2OD1zMD6wNVk{KM7:TR?= NFHGSmxUSU6JRWK=
NCI-H2452 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2npWmlEPTB;MUCuNVYh|ryP NGrEO3VUSU6JRWK=
NCI-H1395 M{LUOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;heGlEPTB;MUCuNVc5KM7:TR?= MnTkV2FPT0WU
NCI-H2052 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXMbGVkUUN3ME2xNE4yQDh{IN88US=> M2fYXXNCVkeHUh?=
A375 NYTCW|JLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPDTWM2OD1zMD6yOFUzKM7:TR?= MXnTRW5ITVJ?
HCC38 NFrldnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDJfVBbUUN3ME2xNE4{OjJizszN MUHTRW5ITVJ?
LK-2 MlHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TtNWlEPTB;MUCuOFIxQCEQvF2= NXfSVId1W0GQR1XS
SF126 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4WwXWlEPTB;MUCuOFczPyEQvF2= MljjV2FPT0WU
SK-MEL-1 MnPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvYT3VKSzVyPUGwMlc5OzhizszN MkTYV2FPT0WU
ACN MnnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTFyLki2O|kh|ryP MlTZV2FPT0WU
BB30-HNC M4nUZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnNSVFKSzVyPUGwMlg4OTFizszN MYnTRW5ITVJ?
NCI-H747 Mmq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnETWM2OD1zMD64O|Q3KM7:TR?= MUTTRW5ITVJ?
KYSE-150 M4HwWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rXZWlEPTB;MUGuNFM5PyEQvF2= NV7YTJFRW0GQR1XS
D-247MG NFTz[5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTFzLkGwNFkh|ryP NXrnbXVRW0GQR1XS
BxPC-3 NGLKXHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7MdoFKSzVyPUGxMlM4PDdizszN NELJWHhUSU6JRWK=
SK-MEL-30 NGn5R3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlP4TWM2OD1zMT60NFc6KM7:TR?= NY\jfZh[W0GQR1XS
CAS-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTjTWM2OD1zMT60NVA6KM7:TR?= MXnTRW5ITVJ?
no-10 NGLPS2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjPTWM2OD1zMj6xNlE4KM7:TR?= MUPTRW5ITVJ?
NCI-H2405 M1PSS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfNSYJ4UUN3ME2xNk4zODN4IN88US=> M4T2T3NCVkeHUh?=
KGN NXn2ZXFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7XPGRKSzVyPUGyMlI6ODFizszN MXTTRW5ITVJ?
BB49-HNC M2jtfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXhS3hyUUN3ME2xNk4{QTV4IN88US=> NFjYcpFUSU6JRWK=
NCI-H1693 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXKwbVRWUUN3ME2xNk42QDF4IN88US=> MmLEV2FPT0WU
RO82-W-1 NEn6eZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTF|LkC2OFkh|ryP NWfDOVlyW0GQR1XS
CAL-85-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHq4WlFKSzVyPUGzMlQ{QTlizszN NVSxZlVWW0GQR1XS
H-EMC-SS NIfWfGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTnSVhDUUN3ME2xN{46OTB2IN88US=> NEHDNINUSU6JRWK=
SW1783 M{nJNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTF2LkKzPVEh|ryP NETlWXBUSU6JRWK=
LB771-HNC NFf5TZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvq[4RKSzVyPUG0MlQyQSEQvF2= NYjHboRbW0GQR1XS
HCC70 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHjU21tUUN3ME2xOE41OjN|IN88US=> MlLyV2FPT0WU
KNS-81-FD MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLWTJE5UUN3ME2xOE44ODR3IN88US=> MlrHV2FPT0WU
KYSE-520 Ml\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\kV2lEPTB;MUSuPVI4KM7:TR?= NWnURnplW0GQR1XS
TGBC24TKB MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzITWM2OD1zND65OVM6KM7:TR?= MmHWV2FPT0WU
SNB75 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnqUnlKSzVyPUG1MlA4OjlizszN MXPTRW5ITVJ?
SW872 Mn;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Lq[WlEPTB;MUWuNlIyQCEQvF2= NF7xSWFUSU6JRWK=
U031 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3BNm9KSzVyPUG1MlgxOjhizszN MmSzV2FPT0WU
ChaGo-K-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTUbmtKSzVyPUG1Mlg{PTlizszN Moq2V2FPT0WU
NCI-H441 NUD6W3VwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlj1TWM2OD1zNj6wNFM6KM7:TR?= MX\TRW5ITVJ?
TE-12 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEf1[|RKSzVyPUG2MlE5PzNizszN MUjTRW5ITVJ?
NCI-H1755 Ml3oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTF4LkW3N{DPxE1? Mn\0V2FPT0WU
KNS-42 Ml;XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTF4Lk[1PFkh|ryP MUjTRW5ITVJ?
SK-PN-DW MnPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1v4RWlEPTB;MUeuOFIxOSEQvF2= MoH3V2FPT0WU
NCI-H226 NGDhfpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PYPGlEPTB;MUeuPVM1PSEQvF2= NHq5TJJUSU6JRWK=
K-562 M3WzPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTF6Lk[zNVch|ryP MUPTRW5ITVJ?
A388 MnjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fkdGlEPTB;MUmuNFMxOyEQvF2= NH[yS2VUSU6JRWK=
ZR-75-30 NIW0[FZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTF7LkC5Olgh|ryP MnO3V2FPT0WU
LU-135 NHXLVXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjBTWM2OD1zOT6yOlM3KM7:TR?= NGXjU4VUSU6JRWK=
NCI-H2029 M1jzOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLnVG9zUUN3ME2xPU43ODJzIN88US=> MVrTRW5ITVJ?
HT-1197 NGDufYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTF7LkmyNlch|ryP MnH0V2FPT0WU
IGR-1 M3vB[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDpemdKSzVyPUKwMlMyOTdizszN NFHubW9USU6JRWK=
U-87-MG NFXFUIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILqXZlKSzVyPUKwMlY1OTNizszN Mm\jV2FPT0WU
NCI-H1304 Mn7pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TaRWlEPTB;MkCuO|UxOSEQvF2= MVrTRW5ITVJ?
RCC10RGB M3LOS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LMfmlEPTB;MkGuNlgzQSEQvF2= MXHTRW5ITVJ?
NCI-H520 NISzfo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUSwOY9GUUN3ME2yNk44PjFzIN88US=> NY\y[|lyW0GQR1XS
SK-LU-1 M{XUZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljUTWM2OD1{Mz6wO|E5KM7:TR?= MWXTRW5ITVJ?
UACC-893 NYm3dpRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTqTWM2OD1{Mz6xNFM5KM7:TR?= NWrnUIdsW0GQR1XS
NCI-H2347 M3S4XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfGN5VpUUN3ME2yN{4zPjd2IN88US=> MXnTRW5ITVJ?
U-118-MG MlvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXX1PFZ2UUN3ME2yN{44OjF5IN88US=> M1LnNnNCVkeHUh?=
NCI-H596 NGLCZ25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTJbHN{UUN3ME2yN{46ODV3IN88US=> MV7TRW5ITVJ?
MZ1-PC M{nucmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUL0WXpTUUN3ME2yOE43PzV7IN88US=> NFzXfHdUSU6JRWK=
SW1417 NX3LeXZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfLeXFKSzVyPUK1MlI1QThizszN M{DKbnNCVkeHUh?=
NCI-H82 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2qxUGlEPTB;Mk[uOFI5QCEQvF2= NH3HRVNUSU6JRWK=
COLO-678 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTkTWM2OD1{Nz60PVE6KM7:TR?= MYTTRW5ITVJ?
KURAMOCHI NGj1d5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlezTWM2OD1{OD6xNlYh|ryP MULTRW5ITVJ?
NCI-H1650 MmniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3T5fmlEPTB;M{CuNVkzPCEQvF2= NVXv[ZhFW0GQR1XS
HCC1954 MnjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nHSWlEPTB;M{GuN|Y3PiEQvF2= M4nZSHNCVkeHUh?=
GAK NXqzd3hzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTnTWNKSzVyPUOyMlI3OTZizszN Mn7nV2FPT0WU
YAPC MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILsb41KSzVyPUOzMlc3PDhizszN Mmr4V2FPT0WU
NCI-H2228 NWnJW3pNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXFTWM2OD1|ND6zOlA2KM7:TR?= MoewV2FPT0WU
VMRC-RCZ NFKyVWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnhXGRNUUN3ME2zOk4{ODJ{IN88US=> NFHOOZVUSU6JRWK=
NMC-G1 NEWxV4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTN5LkC1Nlkh|ryP M1XGNHNCVkeHUh?=
D-336MG NV;RTZo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfxfohKSzVyPUSxMlg1PDJizszN MlTTV2FPT0WU
UACC-62 NHm4T2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonxTWM2OD12Mj61OVA2KM7:TR?= MYHTRW5ITVJ?
C-33-A NXWwbpcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3i4b2lEPTB;NEWuN|I2PiEQvF2= NWDRdGFjW0GQR1XS
HCC1937 NVn3b2twT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTR5LkG5OVgh|ryP NFzBN|hUSU6JRWK=
HDLM-2 M{LYfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4n2[mlEPTB;NEeuNlI5PyEQvF2= NUX5cHlmW0GQR1XS
NCI-H727 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3mPZNKSzVyPUS3MlI1PTFizszN M3rKPXNCVkeHUh?=
NY MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnTOXpJUUN3ME20PU4{QTB6IN88US=> NFrUOXJUSU6JRWK=
NCI-H2291 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTR7LkizNFEh|ryP MYXTRW5ITVJ?

多くの細胞株試験データを見る場合、クリックしてください

体内試験 Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

お薦めの試験操作(参考用のみ)

キナーゼ試験:

[1]

+ 展開

Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
細胞試験:

[2]

+ 展開
  • 細胞株: LNCaP, PC-3, and TSU-Pr1
  • 濃度: Dissolved in DMSO, final concentrations ~7.5 μM
  • 反応時間: 1, 2, 3 and 4 days
  • 実験の流れ:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (参考用のみ)
動物試験:

[2]

+ 展開
  • 動物モデル: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • 製剤: Dissolved in DMSO
  • 投薬量: ~100 mg/kg/day
  • 投与方法: Injection i.p.
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
体内 順序で溶剤を入れること:
2% DMSO+30% PEG 300+ddH2O
5mg/mL

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 264.3
化学式

C14H20N2O3

CAS No. 149647-78-9
保管
別名 SAHA, MK0683, suberoylanilide hydroxamic acid

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01059552 Active, not recruiting Locally Advanced Non-small Cell Lung Cancer Fox Chase Cancer Center|National Comprehensive Cancer Network December 6, 2009 Phase 1
NCT02108002 Enrolling by invitation Von Hippel-Lindau Disease National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) March 5, 2014 Phase 1
NCT03022565 Not yet recruiting Uveal Melanoma Nicolas Acquavella|University of Miami Sylvester Comprehensive Cancer Center|University of Miami April 2017 --
NCT02943642 Not yet recruiting Mycosis Fungoides Angimmune LLC|City of Hope National Medical Center|Columbia University|Dana-Farber Cancer Institute|Feinberg School of Medicine, Northwestern University|H. Lee Moffitt Cancer Center and Research Institute|Ohio State University Comprehensive Cancer Center|Rush University Medical Center|Scott and White Hospital & Clinic|Yale University|Stanford University|Thomas Jefferson University|University of Arkansas|University of Colorado Denver School of Medicine Barbara Davis Center|University of Texas Southwestern Medical Center|University of Washington|Vanderbilt University School of Medicine|Washington University School of Medicine January 2017 Phase 2
NCT02836548 Recruiting Melanoma|Skin Neoplasms The Netherlands Cancer Institute June 2016 Phase 1|Phase 2
NCT02589145 Recruiting Lymphoma M.D. Anderson Cancer Center|Celgene Corporation June 2016 Phase 1|Phase 2

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

HDAC信号経路図

HDAC Inhibitors with Unique Features

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Tags: Vorinostat (SAHA, MK0683)を買う | Vorinostat (SAHA, MK0683) ic50 | Vorinostat (SAHA, MK0683)供給者 | Vorinostat (SAHA, MK0683)を購入する | Vorinostat (SAHA, MK0683)費用 | Vorinostat (SAHA, MK0683)生産者 | オーダーVorinostat (SAHA, MK0683) | Vorinostat (SAHA, MK0683)化学構造 | Vorinostat (SAHA, MK0683)分子量 | Vorinostat (SAHA, MK0683)代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID