Vorinostat (SAHA, MK0683)

製品コードS1047 別名:SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683)化学構造

分子量(MW):264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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文献中の使用例(100)

カスタマーフィードバック(20)

  • Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

    D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

製品安全説明書

HDAC阻害剤の選択性比較

生物活性

製品説明 Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
ターゲット
HDAC [1]
(Cell-free assay)
~10 nM
体外試験

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 NV72dVhVU2mwYYPlJGF{e2G7 MoX4NUBp MXfEUXNQ NVzCcI9V[W62aT3ISGFEOSCjY4Tpeol1gSC5aYToJGlEPTBib3[gNE4yOTJizszN NXjjdodvOTF7NkC0PFk>
Friend leukemic cell MorlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXi2cVRZPTBizszN NEP1V484OiCq M1nzN2ROW09? M2jO[2lEPTB;MD65PUDPxE1? M{HzUVEzOTB7OUGz
K562 Ml30T4lv[XOnIFHzd4F6 M1rPRlYhcA>? M1jnZWROW09? NV3WNWtDUW6qaXLpeIlwdiCxZjDoeY1idiCqaYP0c45mKGSnYXPleJlt[XOnIDjtbZh1fXKnIH;mJGhFSUNzIHHu[EBJTEGFMjmge4l1cCCLQ{WwJI9nKDBwMEGg{txO NGrKdpMyOjRzOUO4NC=>
HT1080 NYDqcYVFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknyO|IhcA>? MUPEUXNQ NIS3UFBKSzVyPUKuOEDPxE1? MorrNVIzPzBzN{W=
H1299 M33ETWtqdmG|ZTDBd5NigQ>? Mm\XNlAhdWmw MnP4SG1UVw>? MnjVTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JGhFSUNiZX76fY1mKHerdHigTWM2OCCxZjCwMlE6PCEQvF2= MXyxOFUzOTR{Mh?=
H1299 MorFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWW3NkBp NXTweppRTE2VTx?= MnT1TWM2OD15LkK0JO69VQ>? M1rUNVE1PTJzNEKy
HeLa M4XkNGtqdmG|ZTDBd5NigQ>? M1TQTFMxKG2rbh?= MmX3TY5pcWKrdH;yfUBkd26lZX70doF1cW:wIHHnZYlve3RiaHnzeI9v\SCmZXHj[ZR6dGG|ZTD3bZRpKEmFNUCgc4YhOC5{ODFOwG0> M3v0UVE2PjB|OUS5
LOX-IMVI NFzOeWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXpOFghcA>? NV7ue|dmUUN3ME2xMlMh|ryP MXSxOVcyPTR5MB?=
NCI-H226 MlXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPjeos1QCCq Mk\YTWM2OD1{Lk[g{txO NEXqd4syPTdzNUS3NC=>
RXF-631L NXTQS|hYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXK3VpBLPDhiaB?= M2XESGlEPTB;MjFOwG0> MljNNVU4OTV2N{C=
SNB-78 M{K4WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWX0WYs{PDhiaB?= Ml3FTWM2OD1zNjFOwG0> NUXscW83OTV5MUW0O|A>
St-4 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrofXY1QCCq Mme4TWM2OD13LkKg{txO Ml7JNVU4OTV2N{C=
ARP1 MlLjSpVv[3Srb36gRZN{[Xl? NYjHd|ZMOiEQvF2= MojEOkBp NHniXYhKdmS3Y4Tpc44hd2ZiUEKxW2FHOSCpZX7lJIV5eHKnc4Ppc44> NYT3NWVOOTR5M{S4NFY>
CEM MlrMT4lv[XOnIFHzd4F6 M{HOZlEhcA>? NIDrV5NFVVOR MV7Jcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwM{Og{txO MmPZNVY1OjByNkS=
HCT15 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUi0PEBp NHK3c2NIUTVyPUCuPFIh|ryP NFf5TmcyPjd{M{KyOy=>
NCI-H23 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUj4NGNEPDhiaB?= NV;yVJhiT0l3ME2wMlkzKM7:TR?= NVPwZlVpOTZ5MkOyNlc>
GM15850 MonHT4lv[XOnIFHzd4F6 NHjIcmYzNjVizszN NV3hToEzQTZiaB?= MX7EUXNQ Mn7rTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSEOgcJl{cW6nIEG0JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n M3HBO|E3QTJzM{[3
GM15850 MofWT4lv[XOnIFHzd4F6 MV2yMlUh|ryP Moj0PVYhcA>? MWDEUXNQ NEXuTY5KdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgOUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= M{ez[VE3QTJzM{[3
GM15850 MkXxT4lv[XOnIFHzd4F6 MXmyMlUh|ryP MUO5OkBp MmewSG1UVw>? M{izNGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTCxNkBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NIXOdokyPjl{MUO2Oy=>
GM15850 NWLtcWsxU2mwYYPlJGF{e2G7 NVTXNmVNOi53IN88US=> MkTtPVYhcA>? MkHOSG1UVw>? Ml3vTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSEOgcJl{cW6nIEmgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? M2DLcVE3QTJzM{[3
GM15850 MXXLbY5ie2ViQYPzZZk> NIfY[ZEzNjVizszN MVu5OkBp M2jU[WROW09? MXfJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViODDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>? NELVZVQyPjl{MUO2Oy=>
GM15850 MofQT4lv[XOnIFHzd4F6 Mof0Nk42KM7:TR?= MYO5OkBp Ml7DSG1UVw>? MojRTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEG2JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n MnLqNVY6OjF|Nke=
U937 Ml3CSpVv[3Srb36gRZN{[Xl? MmmyOUDPxE1? MX2yOEBp M3zmfGROW09? NUnJT5JyS2WubDDjfYNt\SCjcoLld5Qh[nliYXPjeY12dGG2aX;uJIF1KFNxR{KvUUBxcGG|ZR?= MmfLNVcxODR5MUi=
H661 M2DWc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUG0PEBp Mk\PTWM2OD1zIN88US=> MWSxO|E2PzByOR?=
U937 NHzMWnZHfW6ldHnvckBCe3OjeR?= M3\qclUh|ryP MUeyOEBp NV\Xe4M1TE2VTx?= MnfuTY5kemWjc3WgbY4hcGm|dH;u[UBJOyCjY3X0fYxifGmxbh?= NH:2b|AyPzR2N{e1NC=>
U937 NIXnT|FHfW6ldHnvckBCe3OjeR?= MYqxJO69VQ>? NFja[m0zPCCq NHjCOZhFVVOR NIHlUGpG\m[nY4Sgc44h[WyyaHGgeJVjfWyrbjDhZ4V1gWyjdHnvci=> MoT5NVc1PDd5NUC=
RAW264.7 NH\hTWxHfW6ldHnvckBCe3OjeR?= M4\j[lExKM7:TR?= MXSyOIg> MVP3ZZRmeg>? M2HCUGlvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhXE6IYXzwbIEheHKxZIXjeIlwdiC5aYToJGlEPTBib3[gNE44PiEQvF2= NYjZWolXOTd2N{e1NVg>
RAW264.7 MXrGeY5kfGmxbjDBd5NigQ>? NXPLcGU6OTBizszN MnXENlRp MVX3ZZRmeg>? NX7yVlliUW6qaXLpeIlwdiCxZjDMVHMue3SrbYXsZZRm\CCQTzDwdo9lfWO2aX;uJJdqfGhiSVO1NEBw\iBzLki4JO69VQ>? NXLBVHhnOTd2N{e1NVg>
SC9 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHpWJU1PDhiaB?= NVHITmQxUUN3ME2wMlYxPiEQvF2= M{fCd|E4PTB5MkG5
ST14A NV7qcox{TnWwY4Tpc44hSXO|YYm= NWrOUHhqPSCwTR?= NVWz[2Q5PzJiaB?= NX\sTms3UW6lcnXhd4UhcW5iUlXTWE9PWlOIIH3SUmEh\XiycnXzd4lwdg>? NGH3bFYyPzV4NUm5Ny=>
ST14A NGfsPWFHfW6ldHnvckBCe3OjeR?= M{LxUVUhdk1? MoXBO|IhcA>? MmPyTY5kemWjc3WgbY4hTTKIMTDtVm5CKGW6cILld5Nqd25? NXmzVJdNOTd3NkW5PVM>
PANC1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M32zb|Eh|ryP MU\JR|UxRTBwNEWg{txO NVK2VWZUOTd3OEi3OFQ>
PANC1 MlnKSpVv[3Srb36gRZN{[Xl? NEG3boYyKM7:TR?= MlTBNlQhcA>? Mn65TY5kemWjc3WgbY4heDJzV1HGNU9EUVBzIHflcoUh\XiycnXzd4lwdg>? MXexO|U5QDd2NB?=
PANC1 NIT5TVVHfW6ldHnvckBCe3OjeR?= NYi4W3Z6OSEQvF2= MUSyOEBp MYfJcoNz\WG|ZTDpckBxOjetaYCxJIdmdmViZYjwdoV{e2mxbh?= NXrWTVFIOTd3OEi3OFQ>
PT45 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTRizszN MlvzNVc2QDh5NES=
ACHN Moi0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrONlEhcA>? MkfyS2k2OD1yLk[1JO69VQ>? MV2xO|Y3OjZyNh?=
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HepG2 M4KybGtqdmG|ZTDBd5NigQ>? Mni4OUDPxE1? NWTXUHdQPmh? MoG3SG1UVw>? NWHlTnZYUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhUDNxSESgbIl{fG:wZTDhZ4V1gWyjdHnvci=> Mnz5NlAyPDN6NEC=
COLO205 MXvLbY5ie2ViQYPzZZk> MnPqNVAh|ryP MVeyOEBp NHPScY5FVVOR NHW4SZNKdmirYnn0bY9vKG:oIFjERWMyKGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBpcXO2b37lJGg{KGGlZYT5cIF1cW:wIIfpeIghUUN3MDDv[kAzNjJizszN MWGyNFQ2OTN5OB?=
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SCC4 NXG0WGxEU2mwYYPlJGF{e2G7 M2\IblEh|ryP NXfKTXpEOjSq NHOyeVdKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDhZ4V1gWyjdHnvci=> MonKNlA1PTJ{MkW=
SCC4 MVjGeY5kfGmxbjDBd5NigQ>? M3u5c|Eh|ryP NUfTTVB3PSCvaX6= M3vaZWFod26rc4SgZYN1cX[rdImgZZQhXkSUIHHzd4V{e2WmIHHzJIlv\HWldHnvckBw\iCFWWCyOEBo\W6nIHX4dJJme3Orb36= NYXyO4RWOjB2NUKyNlU>
NB4 NHPCPGZHfW6ldHnvckBCe3OjeR?= MnrsOUDPxE1? NEDUfoczPCCq NY\kOJRLTE2VTx?= NV33ZlMzS2WubDDjfYNt\SCjcoLld5Qh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZYNkfW23bHH0bY9vKGG2IIDy[U1IOSCyaHHz[S=> MmHrNlA1QTF2NEC=
NB4 NUPxeGtvU2mwYYPlJGF{e2G7 MorWOUDPxE1? NHHFUpQzPCCq MY\EUXNQ NXvhNlVpUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIFk\XS7bHH0[UB1fWK3bHnuJIxmfmWu MUWyNFQ6OTR2MB?=
NB4 NXzocZhUTnWwY4Tpc44hSXO|YYm= MmjsOUDPxE1? M13vblI1KGh? MU\EUXNQ NF\MNVBKdmS3Y4Tpc44hd2ZicEKxW2FHOS:FSWCxJIV5eHKnc4Ppc44> NEnKOI0zODR7MUS0NC=>
NB4 M2f1b2tqdmG|ZTDBd5NigQ>? MVu1JO69VQ>? NULpN5lMOjRiaB?= M2jwbGROW09? Ml:4TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSEOgZYNmfHmuYYTpc44> M4DQT|IxPDlzNESw
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A549 NFfIdlFHfW6ldHnvckBCe3OjeR?= MljWOUDPxE1? MnHTN{Bp M123WGROW09? M3zhZ2lv\HWldHnvckBw\iCjdYTvdIhi\3liaX6gbJVu[W5iQUW0PUBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCOQ{PJTS=> MnfMNlA5PTV{MEi=
HUT78 MofHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfpd3U4OiCq MorZSG1UVw>? M2PGV2dKPTB;MD6zJO69VQ>? Ml76NlA5QDR{MEi=
U937 NV3VUGVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\mNGp1PzJiaB?= MkXsSG1UVw>? MoHWS2k2OD1yLkO5JO69VQ>? M4O4NFIxQDh2MkC4
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A549 M4O1TWN6fG:2b4jpZ{BCe3OjeR?= M{TqWVczKGh? NYjhUllYS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTEGFIIfpeIghUUN3MDDv[kAyNjhizszN MnHMNlExQDB4Mkm=
CAL27 NWDqWmJTS3m2b4TvfIlkKEG|c3H5 MYO3NkBp NGfvfoREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBESUx{NzDj[YxteyCxdnXy[ZhxemW|c3nu[{BGT0[UIIfpeIghUUN3MDDv[kA{NjJizszN MXWyNVA5ODZ{OR?=
HeLa M3PmT2N6fG:2b4jpZ{BCe3OjeR?= NH[0NWo4OiCq MlHyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISGFEKHerdHigTWM2OCCxZjCxMlUh|ryP NHHlSFAzOTB6ME[yPS=>
Sf21 NVnVNWV2U2mwYYPlJGF{e2G7 MoHEN{Bp M37qfmlvcGmkaYTpc44hd2ZiRnzh[{B1[WepZXSgbJVu[W5icnXjc41jcW6jboSgTGRCSzhiZYjwdoV{e2WmIIfpeIghUUN3MDDv[kAyNjJizszN MoC1NlExQDB4Mkm=
SKBR3 MnfvR5l1d3SxeHnjJGF{e2G7 NXr0dHlnPzJiaB?= NU\hdWlZS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uEUkOgZ4VtdHNib4\ldoV5eHKnc4PpcochUEWUMjD3bZRpKEmFNUCgc4YhOi54IN88US=> NXntV4JMOjFyOEC2Nlk>
SKOV3 MW\DfZRwfG:6aXOgRZN{[Xl? NU[xNG1rPzJiaB?= NGnrdm5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0:YMzDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTVJ{IIfpeIghUUN3MDDv[kAzNjJizszN M2\mVFIyODhyNkK5
COR-L23 NUDKNoRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\MWFExKM7:TR?= MkTKO|IhcA>? MVHEUXNQ M3j5VmdKPTB;MT6xJO69VQ>? MV6yNVA5ODZ2Nx?=
DU145 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnK0NVAh|ryP NXHJclFNPzJiaB?= MkXwSG1UVw>? MV7HTVUxRTFwMEWg{txO NVqzRZlROjFyOEC2OFc>
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HCT116 NHnDN5lMcW6jc3WgRZN{[Xl? M{fCZVMxKM7:TR?= NXnpUYVrOzBiaB?= MlHYSG1UVw>? NXHMO4RPUW6qaXLpeIlwdiCxZjDISGFEPiCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4Yh[WyyaHGteJVjfWyrbjDhZ4V1gWyjdHnvci=> NXz6cXg5OjFyOEC2OFc>
HCT116 NIj3WmNMcW6jc3WgRZN{[Xl? MUizNEDPxE1? NVXn[HZzOzBiaB?= MlzpSG1UVw>? NWfveXBZUW6qaXLpeIlwdiCxZjDISGFEOSCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhcGm|dH;u[UBJO0t7IHHj[ZR6dGG2aX;u Ml;1NlExQDB4NEe=
U937 NH3QUZhMcW6jc3WgRZN{[Xl? NG\wdmQ2KM7:TR?= NH:1PYozPCCq MnvXSG1UVw>? NWmxSopkUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{m= NGqxWoEzOTJ7MkS5Ni=>
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U937 MYrLbY5ie2ViQYPzZZk> NVe0ZnkyPSEQvF2= M3TWVFI1KGh? MUXEUXNQ NWHBSmM5UW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKHCjbj3hZ4V1gWyjdHXkJIhqe3SxbnWgTFQhdGW4ZXy= NX7ZXmJnOjF{OUK0PVI>
U937 M2nvW2tqdmG|ZTDBd5NigQ>? MkLCOUDPxE1? M{LaVVE2KG2rbh?= MXLEUXNQ NVG2eWtYUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGirc4TvcoUhUDNiYXPleJlt[XSrb36gcIV3\Wx? NWfwTo9zOjF{OUK0PVI>
A2780 NYO1VXBzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLpSZY6PiCq NUfoe2dnTE2VTx?= Ml[zTWM2OD1zLk[yJO69VQ>? NIPnbW8zOTZ|NESzNC=>
COLO205 Mn31S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn[yPVYhcA>? Mo\rSG1UVw>? M{jxNWlEPTB;Mj6xNkDPxE1? M1L4[VIyPjN2NEOw
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GM11272 M{n3XmZ2dmO2aX;uJGF{e2G7 NWPpXm1POTByIH7N M4\DPFczKGh? MWPEUXNQ M4XvSnJm[WO2aY\heIlwdiCxZjDN[WNxOiCvdYThcpQh\XiycnXzd4lwdiCjdDCxNEB1dyBzMECgcm0> Mmq5NlE5PDB5MU[=
CFBE41o NHPHbpZMcW6jc3WgRZN{[Xl? MkDzOUDPxE1? M4TXbGROW09? MoHySI94diC{ZXf1cIF1cW:wIH;mJGhFSUN5IHH0JFAvOiC2bzC1JJVO M{DxSlIyQTh2OUW4
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DU145 MVzLbY5ie2ViQYPzZZk> NH;5VYkzNjVizszN NIf2TGUzPCCq MmiySG1UVw>? NVm1V|cyUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IIXwdoVofWyjdHnvckBw\iCyMkH3ZYYyKHC{b4TlbY4h\XiycnXzd4lwdg>? MmrjNlIzPjBzNk[=
DU145 MX7LbY5ie2ViQYPzZZk> Mn\5OUDPxE1? Mn\WNlQhcA>? NVnYNXIzTE2VTx?= M2qxSmlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCqaYP0c45mKEh2IHHj[ZR6dGG2aX;u MViyNlI3ODF4Nh?=
DU145 NFPaZ|JMcW6jc3WgRZN{[Xl? MUO1JO69VQ>? MnK5NlQhcA>? M{jqRmROW09? MnTFTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGirc4TvcoUhUDNiaInw[ZJi[2W2eXzheIlwdg>? NHuyXHIzOjJ4MEG2Oi=>
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HOP92 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13w[VYvOiEQvF2= NVHvbI46PzJiaB?= NYXQZ29uTE2VTx?= NVjSXFNlT0l3ME20JO69VQ>? MoHCNlI1OzV4Nkm=
IGROV1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXuOk4zKM7:TR?= NX\DR3hTPzJiaB?= M1OwWGROW09? M4G1VmdKPTB;MT6zJO69VQ>? M1izN|IzPDN3Nk[5
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M14 NET1TG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXJVXJWPi5{IN88US=> MVi3NkBp NXvJTnlKTE2VTx?= M3TLXmdKPTB;MT6zJO69VQ>? NWHMToxTOjJ2M{W2Olk>
MALME-3M Mnm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPae4t4Pi5{IN88US=> M4jkV|czKGh? NYezXZkyTE2VTx?= NXz0c2lET0l3ME2wMlMzKM7:TR?= NI\OUGszOjR|NU[2PS=>
MCF10A M{XvdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXWboo3NjJizszN NYCwToFPPDhiaB?= NEmzfXdFVVOR NH\tVotIUTVyPUmuOkDPxE1? NWHPNng{OjJ2M{W2Olk>
MDA-MB-435 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVe2MlIh|ryP MoXrO|IhcA>? MVfEUXNQ MX3HTVUxRTBwNTFOwG0> NHXzWWEzOjR|NU[2PS=>
MDA-MB-468 NFjEbJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnLd283NjJizszN Mn31O|IhcA>? NVvZ[3hHTE2VTx?= Ml:5S2k2OD1yLk[zJO69VQ>? MX:yNlQ{PTZ4OR?=
MOLT4 MmTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYO2MlIh|ryP NVzaeIVSPzJiaB?= NFq0TlNFVVOR NF7JeFJIUTVyPUCuOEDPxE1? NUHaVXdROjJ2M{W2Olk>
NCI-ADR-RES MlX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HDclYvOiEQvF2= M{fuSVczKGh? NFvTOHlFVVOR NXv2WHNHT0l3ME2wMlE3KM7:TR?= MXKyNlQ{PTZ4OR?=
NCI-H23 NEHxUmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVG2MlIh|ryP MVi3NkBp NFrBOlBFVVOR MUTHTVUxRTFizszN NE\ie28zOjR|NU[2PS=>
NCI-H322M MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnubld5Pi5{IN88US=> NFXRe4w4OiCq NXTO[Zc5TE2VTx?= NHr4PIdIUTVyPUCuO|kh|ryP M4[4cFIzPDN3Nk[5
NCI-H460 NHrpXXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnG4Ok4zKM7:TR?= NV\FZ4RzPzJiaB?= NHvDdYZFVVOR NWj1e|BIT0l3ME2wMlc6KM7:TR?= M2T2TFIzPDN3Nk[5
NCI-H522 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYW2MlIh|ryP MWq3NkBp NFj3WoZFVVOR MXXHTVUxRTBwNTFOwG0> MV6yNlQ{PTZ4OR?=
OVCAR3 Mn7WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI[ycJc3NjJizszN MWC3NkBp MUTEUXNQ MYLHTVUxRTFwMzFOwG0> NFrTW3MzOjR|NU[2PS=>
OVCAR4 Mnu3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml[xOk4zKM7:TR?= NWDC[YE5PzJiaB?= NFvBNG1FVVOR M{D3UGdKPTB;NDFOwG0> MmjWNlI1OzV4Nkm=
OVCAR5 MnvrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmexOk4zKM7:TR?= NGHjNHY4OiCq NGLhb|lFVVOR NUnpU|ZHT0l3ME2wMlc6KM7:TR?= NHLYSYMzOjR|NU[2PS=>
OVCAR8 MkTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1eyW|YvOiEQvF2= NXLtPYRiPzJiaB?= NGKzVGdFVVOR NVTVbIN6T0l3ME2wMlUh|ryP Mn;kNlI1OzV4Nkm=
RXF393 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInKZok3NjJizszN M3jPNFczKGh? Mmf5SG1UVw>? MX3HTVUxRTFwMzFOwG0> MVSyNlQ{PTZ4OR?=
SF268 NUnxZ4FPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHTOk4zKM7:TR?= NY\oO5lOPzJiaB?= Moi2SG1UVw>? M13qR2dKPTB;MT62JO69VQ>? NFnibmgzOjR|NU[2PS=>
SF295 M163XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfzOk4zKM7:TR?= MonNO|IhcA>? NV\PVFJtTE2VTx?= NETscXNIUTVyPUGuOkDPxE1? MYCyNlQ{PTZ4OR?=
SF539 NXfYUHNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmiyOk4zKM7:TR?= M1Ttc|czKGh? NWXmZWMzTE2VTx?= MV;HTVUxRTJizszN NFm2[Y8zOjR|NU[2PS=>
SK-MEL-2 NV3YVW5kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUi2MlIh|ryP MmSyO|IhcA>? MmT3SG1UVw>? NGfqSYhIUTVyPUGuN{DPxE1? NXrXOJRZOjJ2M{W2Olk>
SK-MEL-28 MmjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYflSoREPi5{IN88US=> M{TPPFczKGh? NWO4VotpTE2VTx?= NVezZlRjT0l3ME2xJO69VQ>? MXqyNlQ{PTZ4OR?=
SK-MEL-5 NFrsXodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVu2MlIh|ryP NI\pXW84OiCq NWWyPW86TE2VTx?= NFPESWNIUTVyPUCuOlMh|ryP NFnEb3EzOjR|NU[2PS=>
SKOV3 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\yVIg3NjJizszN Mle5O|IhcA>? MmriSG1UVw>? NHnIS|ZIUTVyPUGg{txO MVSyNlQ{PTZ4OR?=
SN12C MnzMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LWR|YvOiEQvF2= MVq3NkBp NE\tNGhFVVOR MW\HTVUxRTJizszN MWGyNlQ{PTZ4OR?=
SNB19 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;FWXI3NjJizszN MXu3NkBp NFHMd2FFVVOR MV;HTVUxRTBwNkOg{txO NIO3fFkzOjR|NU[2PS=>
SNB75 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjkZ3k3NjJizszN MYS3NkBp NFvvVFJFVVOR NU\zSHN6T0l3ME2wMlc6KM7:TR?= MUWyNlQ{PTZ4OR?=
SR NYD0TY13T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjLfoF1Pi5{IN88US=> MVq3NkBp NGTBVFJFVVOR MUnHTVUxRTBwNDFOwG0> NW\kWW17OjJ2M{W2Olk>
T47D M162NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlX0Ok4zKM7:TR?= M2PKNFczKGh? MVLEUXNQ M1jqVWdKPTB;MD61JO69VQ>? MlvONlI1OzV4Nkm=
TK10 MmmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVj4[4R7Pi5{IN88US=> MVK3NkBp NYPIfmExTE2VTx?= NFLm[HFIUTVyPUCuOlMh|ryP NUTDN402OjJ2M{W2Olk>
UACC257 NWDVVm85T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWe2MlIh|ryP MX:3NkBp MXrEUXNQ NFzFOXVIUTVyPUCuOUDPxE1? M3LTTFIzPDN3Nk[5
UACC62 Mlz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrVOk4zKM7:TR?= MX23NkBp NYj3NXltTE2VTx?= M4TmTGdKPTB;MD60JO69VQ>? M2[xe|IzPDN3Nk[5
UO31 NYe5NIl6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{mzVFYvOiEQvF2= M13RflczKGh? MYrEUXNQ MmLFS2k2OD1yLkWg{txO NWrPbVVXOjJ2M{W2Olk>
Hep3B NF\GcI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1O3ZVQ5KGh? NWDzNW5{TE2VTx?= MnPkS2k2OD1yLk[5JO69VQ>? M{fFcVIzPDN7OE[z
BE(2)-C MnvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLjPGk4OiCq NXftTpl{TE2VTx?= Mmi2TWM4OD1{IN88US=> M3rhZVIzQTN{M{G2
Bel7402 NYnBPFhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWW3NkBp MlLqSG1UVw>? NX;KblBUT0l7ME2xO{DPxE1? M4Pa[lI{ODZzM{e2
Bel7404 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1Lhe|czKGh? M2jpW2ROW09? NW\HOGloT0l7ME2xPEDPxE1? MUmyN|A3OTN5Nh?=
BGC823 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUm3NkBp NHrHempFVVOR NITQdZlIUTlyPUeuOUDPxE1? MXSyN|A3OTN5Nh?=
MGC803 NXvLcIt{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Dpc|czKGh? MmfaSG1UVw>? MonUS2k6OD1zMD64JO69VQ>? NH\hdXQzOzB4MUO3Oi=>
SGC7901 NUDXbVNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jFSVczKGh? MkLZSG1UVw>? MWnHTVkxRTlwNDFOwG0> MkC1NlMxPjF|N{[=
SKHEP1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrVO|IhcA>? NEHNV|NFVVOR NW\JcmJjT0l7ME2xO{DPxE1? NFXCcZIzOzB4MUO3Oi=>
SMMC7721 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXz0bZpxPzJiaB?= NE\2bZhFVVOR NHX2e5RIUTlyPUKwJO69VQ>? MWGyN|A3OTN5Nh?=
NUGC3 MojJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonwNVAh|ryP NYPkeVY6T0l;Mj65OEDPxE1? MXqyN|E3OzN|Mh?=
A2780 CisR NHXZW2JMcW6jc3WgRZN{[Xl? NYTDR21LOThiaB?= NWrrXpZHUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlQ1KM7:TR?= M3X3UFI{OjV{NkCz
CAL27 sens Ml;NT4lv[XOnIFHzd4F6 MWGxPEBp NYrKUJdnUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlM3KM7:TR?= M{LMclI{OjV{NkCz
CAL27 CisR NXnuWm1GU2mwYYPlJGF{e2G7 Ml\YNVghcA>? NH76VoJKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOlEh|ryP NGLwV3YzOzJ3Mk[wNy=>
KYSE-510 CisR Mlr0T4lv[XOnIFHzd4F6 MlLzNVghcA>? M1PQb2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD61PUDPxE1? MoTVNlMzPTJ4MEO=
KYSE-510 sens M1rWb2tqdmG|ZTDBd5NigQ>? MVexPEBp MoPCTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkeg{txO MWWyN|I2OjZyMx?=
MDA-MB-231 sens MoSzT4lv[XOnIFHzd4F6 NWXSbpR5OThiaB?= M1n2V2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? NIXNN|AzOzJ3Mk[wNy=>
MDA-MB-231 CisR M1nTOmtqdmG|ZTDBd5NigQ>? NVTme2Z5OThiaB?= NYLHWVEyUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?= MkL0NlMzPTJ4MEO=
ES2 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUm0PEBp MorqSG1UVw>? M1K5[2lEPTB;MUKuO{DPxE1? NV7vbXlxOjN2OUO0OFk>
MDA-MB-231 M3vhd2tqdmG|ZTDBd5NigQ>? MkfVNVAh|ryP NWnJcIh6OzBibXnu MUPEUXNQ MonhTY5pcWKrdHnvckBw\iCKRFHDNoE> NUPZOpZWOjN2OUO0OFk>
MDA-MB-231 NHnLbFJMcW6jc3WgRZN{[Xl? NFv1XGIyKM7:TR?= MUmyOEBp MYXEUXNQ M2Pw[mlvcGmkaYTpc44hd2ZiSFTBR|Yh[XO|ZYPz[YQh[XNiYXPleJlt[XSrb36gcIV3\Wy|IH;mJJR2[nWuaX6= NWfD[mdHOjN2OUO0OFk>
HS68 NHy1O2xEgXSxdH;4bYMhSXO|YYm= NEjYemgyOCEQvF2= M2fJT|czKGh? Ml7iSG1UVw>? MWHJR|UxRTRwNjFOwG0> MYmyN|U4ODV2Mh?=
MEF MWfDfZRwfG:6aXOgRZN{[Xl? MXyxNEDPxE1? MUK3NkBp NXiw[ZpLTE2VTx?= MYPJR|UxRTRwNDFOwG0> NF7OfXEzOzV5MEW0Ni=>
BGC823 M4\DPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DMfGROW09? NIjmcJJIUTVyPUOuNFkh|ryP NWrqU5dkOjN4MEG3NFY>
High5 NUXqO5dUU2mwYYPlJGF{e2G7 MUKyOEBp MV\Jcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVO2JJdqfGhiSVO1NEBw\iByLkC5JO69VQ>? NHzUTZkzOzZyMkWyNy=>
High5 NHmwbohMcW6jc3WgRZN{[Xl? MWCyOEBp NXLEOW46UW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEOSC5aYToJGlEPTBib3[gNE4yOiEQvF2= NI\4UIIzOzZyMkWyNy=>
High5 M3y1NGtqdmG|ZTDBd5NigQ>? M33TdVI1KGh? NV;ZW257UW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEOyC5aYToJGlEPTBib3[gNE4yPyEQvF2= NGjqXGozOzZyMkWyNy=>
A549 NF7vNnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFz5dXJFVVOR M330NGlEPTB;MT6wO|kh|ryP MoTyNlM3PDR{MUC=
HCT116 NGP2NVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjrfYpFVVOR MlnjTWM2OD1yLke1O{DPxE1? MVSyN|Y1PDJzMB?=
K562 Moj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLqZ2c4TE2VTx?= MWLJR|UxRTBwNkS1JO69VQ>? MmXoNlM3PDR{MUC=
GBC-SD MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoqzOUDPxE1? NFq3PYg4OiCq MkXESG1UVw>? M1q5T2lEPTB;MUSuPEDPxE1? M3nRVFI{PzB5Mk[w
HGC27 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVq1JO69VQ>? M3\hWlczKGh? MnPTSG1UVw>? MnrsTWM2OD13LkSg{txO NXr0endIOjN5MEeyOlA>
HL60 Mki2T4lv[XOnIFHzd4F6 NFTUflY2KM7:TR?= NX\LSY9lOjRiaB?= NX\qNXVkTE2VTx?= NFn0dlJKdmirYnn0bY9vKG:oIFjERWM> NWGyRoxQOjN5MEeyOlA>
Vero MmHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTJUml5PzJiaB?= MUHEUXNQ M3XSfGlEPTB;MD65JO69VQ>? NWPyWZZsOjN5OE[0OVI>
NCI60 MWTDfZRwfG:6aXOgRZN{[Xl? M2nKXVQ5KGh? NUXVfYtmTE2VTx?= NH;4R4tIUT1yLkWzJO69VQ>? MWmyOFAyPTN{Nx?=
SW620 Moe5R5l1d3SxeHnjJGF{e2G7 M3zKRVQ5KGh? MW\EUXNQ MoT2S2k:OC53NDFOwG0> NFXjWIszPDBzNUOyOy=>
U251 Mk\HR5l1d3SxeHnjJGF{e2G7 M{jiXVQ5KGh? MkLySG1UVw>? MY\HTV0yNjV|IN88US=> MYiyOFAyPTN{Nx?=
KM12 NHX6RoREgXSxdH;4bYMhSXO|YYm= NIq3cXg1QCCq Ml7uSG1UVw>? MVrHTV0yNjh6IN88US=> NVLFb5Q6OjRyMUWzNlc>
Hs578T NF3qVopEgXSxdH;4bYMhSXO|YYm= NUfNeVF{PDhiaB?= MUfEUXNQ NHXGW21IUT12LkizJO69VQ>? M1LW[|I1ODF3M{K3
MDA-MB-231 NHey[FBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvVZXBSPDhiaB?= M{ftVWlEPTB;MD6xOkDPxE1? NYfF[XRTOjRyOUWwNVY>
MCF7 M2rXTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVe0PEBp MYHHTV0xNjR3IN88US=> Mkf4NlQyOTl3NUW=
MDA-MB-435 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTjOFghcA>? NGPER4dIUT1yLki4JO69VQ>? MWCyOFEyQTV3NR?=
AsPC1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWOzNEDPxE1? NHvWcFQ1QCCq NILaWGxFVVOR NXjVfZI4UUN3ME2zMlY3KM7:TR?= M1TsNVI1OTh3M{e4
Jurkat E6.1 NWXjW2QzU2mwYYPlJGF{e2G7 Mk\CNkBp NHjwfmxFVVOR NVX3[3pUUW6qaXLpeIlwdiCxZjDISGFEPCC5aYToJGlEPTBib3[gNE4xPCEQvF2= NG\DVpczPDJ4MUi2Ni=>
KG1 M2XwTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\IUJNDPDhiaB?= MYLJR|UxRTFwMUWg{txO MoHhNlQ2OjVyMEO=
HEL NHy2eVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPROFghcA>? NV7kVldUTE2VTx?= NFG3NHZKSzVyPUCuOFkh|ryP Mlv4NlQ3QTRyNUW=
HSC3 NEDmNldEgXSxdH;4bYMhSXO|YYm= Mk\CNVIhcA>? NYCxbVN1TE2VTx?= MYLJR|UxRTBwN{Gg{txO NHXZRo0zPDd4NkW2NC=>
HT-29 NIDlcFFEgXSxdH;4bYMhSXO|YYm= M1zSbVEzKGh? NGfP[GtFVVOR NXvDU4U6UUN3ME2wMlczKM7:TR?= Ml\iNlQ4PjZ3NkC=
KB NIXOZnVEgXSxdH;4bYMhSXO|YYm= MXSxNkBp MV3EUXNQ NVrGOZJnUUN3ME2wMlc2KM7:TR?= MWCyOFc3PjV4MB?=
H460 NXrLZ413S3m2b4TvfIlkKEG|c3H5 NFLhR2syOiCq MXPEUXNQ MYrJR|UxRTBwOEKg{txO MXWyOFc3PjV4MB?=
MONE1 Mn;jR5l1d3SxeHnjJGF{e2G7 Mn\TNVIhcA>? NIezW4VFVVOR MULJR|UxRTFwMUig{txO NE\UTpIzPDd4NkW2NC=>
MKN45 NXTCXJE2S3m2b4TvfIlkKEG|c3H5 M1HoblEzKGh? MmDCSG1UVw>? M1vpOWlEPTB;MT6yOUDPxE1? M2rSUVI1PzZ4NU[w
TSGH MmH3R5l1d3SxeHnjJGF{e2G7 MYixNkBp MnXjSG1UVw>? MkXwTWM2OD1{LkC5JO69VQ>? MlXjNlQ4PjZ3NkC=
HL60 NY\1[GF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVO3NkBp MUXEUXNQ M3HYcWdKPTB;MD65N{DPxE1? NFT3eoUzPDlyMEWwNC=>
HEK293 NULWR5E2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYe3NkBp NYfROXY2TE2VTx?= NITmcolIUTVyPUGzJO69VQ>? M2LY[VI1QTByNUCw
Jurkat MmjER5l1d3SxeHnjJGF{e2G7 NGThNmMyODBizszN Ml35O|IhcA>? NILueIpIUTVyPUCuPUDPxE1? MVKyOFkxODd2Mx?=
GM15850 MlLwT4lv[XOnIFHzd4F6 NEfzOowzNjVizszN NGjPW3g6PiCq MX7EUXNQ MX7kc4V{KG6xdDDpcohq[mm2IFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgNVQh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NWHh[WNbOTZ7MkGzOlc>
GM15850 NET3[YVMcW6jc3WgRZN{[Xl? NFTjR4ozNjVizszN NX;2XW9GQTZiaB?= M{L1fGROW09? MnHh[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFUh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NH3Yfm0yPjl{MUO2Oy=>
GM15850 MUjLbY5ie2ViQYPzZZk> MWiyMlUh|ryP NIO5PHE6PiCq NXLUfoUyTE2VTx?= Mn\Y[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFEzKGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MUWxOlkzOTN4Nx?=
GM15850 MYrLbY5ie2ViQYPzZZk> MlvINk42KM7:TR?= MW[5OkBp M{XYbGROW09? MmXP[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFkh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NILrUIgyPjl{MUO2Oy=>
GM15850 MlvkT4lv[XOnIFHzd4F6 NGW4cFgzNjVizszN NYTBUZI3QTZiaB?= NXf6WYF6TE2VTx?= NEXmW|Jld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJPCCueYPpcoUhQCCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> NGHaZYkyPjl{MUO2Oy=>
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NCI-H2052 NXLOSFlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTFyLkG4PFIh|ryP Ml64V2FPT0WU
A375 NGSySHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPkWFFKSzVyPUGwMlI1PTJizszN MWrTRW5ITVJ?
HCC38 M1TsRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjvTWM2OD1zMD6zNlIh|ryP MmXZV2FPT0WU
LK-2 MlPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DENGlEPTB;MUCuOFIxQCEQvF2= M332ZnNCVkeHUh?=
SF126 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljrTWM2OD1zMD60O|I4KM7:TR?= NWXNVm1TW0GQR1XS
SK-MEL-1 NIS0cIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlP0TWM2OD1zMD63PFM5KM7:TR?= MX7TRW5ITVJ?
ACN M4DDNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLyWmV1UUN3ME2xNE45Pjd7IN88US=> NF3lb3lUSU6JRWK=
BB30-HNC NXnRNnlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInVUGtKSzVyPUGwMlg4OTFizszN MUHTRW5ITVJ?
NCI-H747 M4PrPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTvVY5KSzVyPUGwMlg4PDZizszN MUfTRW5ITVJ?
KYSE-150 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTFzLkCzPFch|ryP Mo\MV2FPT0WU
D-247MG MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELteohKSzVyPUGxMlExODlizszN MVPTRW5ITVJ?
BxPC-3 MmTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrnWGtKSzVyPUGxMlM4PDdizszN NH[4VpdUSU6JRWK=
SK-MEL-30 M32yUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvaVnBQUUN3ME2xNU41ODd7IN88US=> MUfTRW5ITVJ?
CAS-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTFzLkSxNFkh|ryP NGrWR3pUSU6JRWK=
no-10 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1K4bWlEPTB;MUKuNVIyPyEQvF2= NG\ue2NUSU6JRWK=
NCI-H2405 NX70dHVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTF{LkKwN|Yh|ryP MY\TRW5ITVJ?
KGN M1GzOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;LS2lEPTB;MUKuNlkxOSEQvF2= NWG2T3FFW0GQR1XS
BB49-HNC NHrHU3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTF{LkO5OVYh|ryP MlTWV2FPT0WU
NCI-H1693 NVW4XpV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLmeGFKSzVyPUGyMlU5OTZizszN NHnJcVVUSU6JRWK=
RO82-W-1 MlrqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTF|LkC2OFkh|ryP NFTaTYlUSU6JRWK=
CAL-85-1 MmLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHoPIhKSzVyPUGzMlQ{QTlizszN Ml\HV2FPT0WU
H-EMC-SS NWrlU3djT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonzTWM2OD1zMz65NVA1KM7:TR?= M4jZTXNCVkeHUh?=
SW1783 M2j6fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1WySmlEPTB;MUSuNlM6OSEQvF2= MlX0V2FPT0WU
LB771-HNC MlP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHTfXBKSzVyPUG0MlQyQSEQvF2= NUDnN5JtW0GQR1XS
HCC70 M2PLOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTF2LkSyN|Mh|ryP MVvTRW5ITVJ?
KNS-81-FD NU\VNYNbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnxZWE2UUN3ME2xOE44ODR3IN88US=> MYjTRW5ITVJ?
KYSE-520 M33DTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknXTWM2OD1zND65Nlch|ryP MofzV2FPT0WU
TGBC24TKB NITCW|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnDNmc1UUN3ME2xOE46PTN7IN88US=> MkGyV2FPT0WU
SNB75 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvqTWM2OD1zNT6wO|I6KM7:TR?= NYHlV5Z6W0GQR1XS
SW872 MlGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlv6TWM2OD1zNT6yNlE5KM7:TR?= NGrOeoFUSU6JRWK=
U031 NWL2NZpGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DSWWlEPTB;MUWuPFAzQCEQvF2= NYLkbJk1W0GQR1XS
ChaGo-K-1 M{TOOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTF3LkizOVkh|ryP MWjTRW5ITVJ?
NCI-H441 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTF4LkCwN|kh|ryP MVrTRW5ITVJ?
TE-12 MkPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTF4LkG4O|Mh|ryP Mlq4V2FPT0WU
NCI-H1755 MnniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7qcGRlUUN3ME2xOk42PzNizszN MU\TRW5ITVJ?
KNS-42 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PhV2lEPTB;MU[uOlU5QSEQvF2= M1;SSnNCVkeHUh?=
SK-PN-DW MmjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTCTWM2OD1zNz60NlAyKM7:TR?= NXHCVoZuW0GQR1XS
NCI-H226 Mn3ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILW[5RKSzVyPUG3Mlk{PDVizszN MlvxV2FPT0WU
K-562 NW\IbGFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jKUGlEPTB;MUiuOlMyPyEQvF2= MUXTRW5ITVJ?
A388 M2PUdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTF7LkCzNFMh|ryP NFzlWJlUSU6JRWK=
ZR-75-30 NVPlclFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;5R4pKSzVyPUG5MlA6PjhizszN MnjXV2FPT0WU
LU-135 M3fmW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTF7LkK2N|Yh|ryP NWXTfY5yW0GQR1XS
NCI-H2029 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTF7Lk[wNlEh|ryP M1rnNHNCVkeHUh?=
HT-1197 M2\hc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jzXGlEPTB;MUmuPVIzPyEQvF2= NFHFT4ZUSU6JRWK=
IGR-1 NX\pbGI1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzQTWM2OD1{MD6zNVE4KM7:TR?= MY\TRW5ITVJ?
U-87-MG NEL2eXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTJyLk[0NVMh|ryP MY\TRW5ITVJ?
NCI-H1304 NYTKXJN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnBPWFKSzVyPUKwMlc2ODFizszN MWnTRW5ITVJ?
RCC10RGB M1W2RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTJzLkK4Nlkh|ryP MoLXV2FPT0WU
NCI-H520 MoCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\1OZhKSzVyPUKyMlc3OTFizszN M1nxSXNCVkeHUh?=
SK-LU-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\CNWlEPTB;MkOuNFcyQCEQvF2= MXLTRW5ITVJ?
UACC-893 M33hfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjOWYJGUUN3ME2yN{4yODN6IN88US=> NXP0SnhwW0GQR1XS
NCI-H2347 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHsXpBmUUN3ME2yN{4zPjd2IN88US=> NGfpUVZUSU6JRWK=
U-118-MG NWfTS4hKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\G[GlEPTB;MkOuO|IyPyEQvF2= M2W1WnNCVkeHUh?=
NCI-H596 NUjDfHBWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPZTWM2OD1{Mz65NFU2KM7:TR?= NW\2cplvW0GQR1XS
MZ1-PC NVXEVoZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jTO2lEPTB;MkSuOlc2QSEQvF2= M2fuN3NCVkeHUh?=
SW1417 NUnPN5A5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\C[4RKSzVyPUK1MlI1QThizszN MoP5V2FPT0WU
NCI-H82 Mm\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPJTWM2OD1{Nj60Nlg5KM7:TR?= M3nsNnNCVkeHUh?=
COLO-678 NXzWemNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXP3WpRYUUN3ME2yO{41QTF7IN88US=> NV3RcGpTW0GQR1XS
KURAMOCHI NXvVXGhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjOTWM2OD1{OD6xNlYh|ryP NEPh[VNUSU6JRWK=
NCI-H1650 NHHn[lJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLoTWM2OD1|MD6xPVI1KM7:TR?= MU\TRW5ITVJ?
HCC1954 M2fvTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfLRYw5UUN3ME2zNU4{PjZ4IN88US=> NH3LfYlUSU6JRWK=
GAK Mn;WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfNTWM2OD1|Mj6yOlE3KM7:TR?= NXfUeoFqW0GQR1XS
YAPC MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjpSYk1UUN3ME2zN{44PjR6IN88US=> MUPTRW5ITVJ?
NCI-H2228 NH;kRoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDXTWM2OD1|ND6zOlA2KM7:TR?= NXf0[4ZVW0GQR1XS
VMRC-RCZ M{TpZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTN4LkOwNlIh|ryP MXTTRW5ITVJ?
NMC-G1 NEDrTlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV36O4JpUUN3ME2zO{4xPTJ7IN88US=> M3zIeXNCVkeHUh?=
D-336MG M3PkUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPoWWdtUUN3ME20NU45PDR{IN88US=> M13RW3NCVkeHUh?=
UACC-62 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;DV2lEPTB;NEKuOVUxPSEQvF2= M3T5RnNCVkeHUh?=
C-33-A MmXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFe2NVBKSzVyPUS1MlMzPTZizszN MXLTRW5ITVJ?
HCC1937 M2TPUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDPcJd1UUN3ME20O{4yQTV6IN88US=> M3P4N3NCVkeHUh?=
HDLM-2 Mm\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HpO2lEPTB;NEeuNlI5PyEQvF2= M1z2b3NCVkeHUh?=
NCI-H727 NXLxOYxIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37uXWlEPTB;NEeuNlQ2OSEQvF2= NV3Y[YN{W0GQR1XS
NY NHfDXVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4j0dmlEPTB;NEmuN|kxQCEQvF2= Ml3jV2FPT0WU
NCI-H2291 NEfLbohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXRbWlKSzVyPUS5Mlg{ODFizszN MlPJV2FPT0WU

多くの細胞株試験データを見る場合、クリックしてください

体内試験 Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

お薦めの試験操作(参考用のみ)

キナーゼ試験:

[1]

+ 展開

Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
細胞試験:

[2]

+ 展開
  • 細胞株: LNCaP, PC-3, and TSU-Pr1
  • 濃度: Dissolved in DMSO, final concentrations ~7.5 μM
  • 反応時間: 1, 2, 3 and 4 days
  • 実験の流れ:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (参考用のみ)
動物試験:

[2]

+ 展開
  • 動物モデル: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • 製剤: Dissolved in DMSO
  • 投薬量: ~100 mg/kg/day
  • 投与方法: Injection i.p.
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
体内 左から右までの手順で、溶剤を製品に加えることです:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
5mg/mL

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 264.3
化学式

C14H20N2O3

CAS No. 149647-78-9
保管
別名 SAHA, MK0683, suberoylanilide hydroxamic acid

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01059552 Active, not recruiting Locally Advanced Non-small Cell Lung Cancer Fox Chase Cancer Center|National Comprehensive Cancer Network December 6, 2009 Phase 1
NCT02108002 Enrolling by invitation Von Hippel-Lindau Disease National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) March 5, 2014 Phase 1
NCT03022565 Not yet recruiting Uveal Melanoma Nicolas Acquavella|University of Miami Sylvester Comprehensive Cancer Center|University of Miami April 2017 --
NCT02943642 Not yet recruiting Mycosis Fungoides Angimmune LLC|City of Hope National Medical Center|Columbia University|Dana-Farber Cancer Institute|Feinberg School of Medicine, Northwestern University|H. Lee Moffitt Cancer Center and Research Institute|Ohio State University Comprehensive Cancer Center|Rush University Medical Center|Scott and White Hospital & Clinic|Yale University|Stanford University|Thomas Jefferson University|University of Arkansas|University of Colorado Denver School of Medicine Barbara Davis Center|University of Texas Southwestern Medical Center|University of Washington|Vanderbilt University School of Medicine|Washington University School of Medicine January 2017 Phase 2
NCT02836548 Recruiting Melanoma|Skin Neoplasms The Netherlands Cancer Institute June 2016 Phase 1|Phase 2
NCT02589145 Recruiting Lymphoma M.D. Anderson Cancer Center|Celgene Corporation June 2016 Phase 1|Phase 2

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

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Tags: Vorinostat (SAHA, MK0683)を買う | Vorinostat (SAHA, MK0683) ic50 | Vorinostat (SAHA, MK0683)供給者 | Vorinostat (SAHA, MK0683)を購入する | Vorinostat (SAHA, MK0683)費用 | Vorinostat (SAHA, MK0683)生産者 | オーダーVorinostat (SAHA, MK0683) | Vorinostat (SAHA, MK0683)化学構造 | Vorinostat (SAHA, MK0683)分子量 | Vorinostat (SAHA, MK0683)代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID