Vorinostat (SAHA, MK0683)

製品コードS1047 別名:SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683)化学構造

分子量(MW):264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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JPY 24402.00
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文献中の使用例(100)

カスタマーフィードバック(20)

  • Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

    D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

製品安全説明書

HDAC阻害剤の選択性比較

生物活性

製品説明 Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
ターゲット
HDAC [1]
(Cell-free assay)
~10 nM
体外試験

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 M3WwcmtqdmG|ZTDBd5NigQ>? NXPnZ4R1OSCq M1OxXWROW09? M{mxe4FvfGlvSFTBR|Eh[WO2aY\peJkhf2m2aDDJR|UxKG:oIECuNVEzKM7:TR?= MYWxNVk3ODR6OR?=
Friend leukemic cell NFjYXIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknXOVAh|ryP M2PyZVczKGh? MXzEUXNQ MlnUTWM2OD1yLkm5JO69VQ>? NE[zbWMyOjFyOUmxNy=>
K562 NV[0O5prU2mwYYPlJGF{e2G7 NYq4Z3NzPiCq M{LNTmROW09? Mm\QTY5pcWKrdHnvckBw\iCqdX3hckBpcXO2b37lJIRm[WOndInsZZNmKCivaYj0eZJmKG:oIFjERWMyKGGwZDDISGFEOilid3n0bEBKSzVyIH;mJFAvODFizszN M{\LZlEzPDF7M{iw
HT1080 Mln4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vUSVczKGh? NXHjPWFUTE2VTx?= MXTJR|UxRTJwNDFOwG0> NGjLSWEyOjJ5MEG3OS=>
H1299 M37DUmtqdmG|ZTDBd5NigQ>? NWLCU3lrOjBibXnu NGn2R|ZFVVOR NVWzN4RJUW6qaXLpeI9zgSCjY4Tpeol1gSCjZ3HpcpN1KEiGQVOg[Y57gW2nIIfpeIghUUN3MDDv[kAxNjF7NDFOwG0> MW[xOFUzOTR{Mh?=
H1299 MnzlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXK3NkBp MmL2SG1UVw>? MVrJR|UxRTdwMkSg{txO MUGxOFUzOTR{Mh?=
HeLa NV:0O2J[U2mwYYPlJGF{e2G7 NU\5O|FkOzBibXnu MlnETY5pcWKrdH;yfUBkd26lZX70doF1cW:wIHHnZYlve3RiaHnzeI9v\SCmZXHj[ZR6dGG|ZTD3bZRpKEmFNUCgc4YhOC5{ODFOwG0> NEC4Zm4yPTZyM{m0PS=>
LOX-IMVI NGTjPYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYK0PEBp MWLJR|UxRTFwMzFOwG0> NXLZ[JROOTV5MUW0O|A>
NCI-H226 NIDJW3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXsOFghcA>? NYL0dmp4UUN3ME2yMlYh|ryP NVXWS|VDOTV5MUW0O|A>
RXF-631L M{DPPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUK0PEBp MnKyTWM2OD1{IN88US=> MlvTNVU4OTV2N{C=
SNB-78 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrlTGg1QCCq MW\JR|UxRTF4IN88US=> NWHwXYFCOTV5MUW0O|A>
St-4 NYrrS3ZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWS0PEBp MkOwTWM2OD13LkKg{txO MYOxOVcyPTR5MB?=
ARP1 M{i3fmZ2dmO2aX;uJGF{e2G7 NELJO3YzKM7:TR?= MWO2JIg> MkD6TY5lfWO2aX;uJI9nKFB{MWfBSlEh\2WwZTDlfJBz\XO|aX;u NGrt[3QyPDd|NEiwOi=>
CEM MlTCT4lv[XOnIFHzd4F6 MY[xJIg> NEm1eXRFVVOR M3fJS2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD6zN{DPxE1? M1XSZVE3PDJyME[0
HCT15 M2jIOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEe4dIQ1QCCq NX3CNZh5T0l3ME2wMlgzKM7:TR?= MmfyNVY4OjN{Mke=
NCI-H23 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXZUo1ZPDhiaB?= NVrO[FdVT0l3ME2wMlkzKM7:TR?= NVrHd5U1OTZ5MkOyNlc>
GM15850 NXLQSFJ{U2mwYYPlJGF{e2G7 MVeyMlUh|ryP NHPFVnQ6PiCq NXvJcHJ4TE2VTx?= M{PRXWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFizJIx6e2mwZTCxOEBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= Ml3FNVY6OjF|Nke=
GM15850 Mki0T4lv[XOnIFHzd4F6 NVP0dlBOOi53IN88US=> MV25OkBp NXf4TZpTTE2VTx?= NHXQbnZKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgOUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NG\BT5gyPjl{MUO2Oy=>
GM15850 NHrVdGlMcW6jc3WgRZN{[Xl? MVSyMlUh|ryP MlHLPVYhcA>? MVrEUXNQ M1fTUWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTCxNkBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MUKxOlkzOTN4Nx?=
GM15850 M2nTb2tqdmG|ZTDBd5NigQ>? NFjzNHMzNjVizszN M3SyN|k3KGh? NWTaUm57TE2VTx?= Mln6TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSEOgcJl{cW6nIEmgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? M3XCRVE3QTJzM{[3
GM15850 MUTLbY5ie2ViQYPzZZk> M2LuW|IvPSEQvF2= Mm\oPVYhcA>? NFTDclFFVVOR NFLHSHBKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgPEBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= M1HsNVE3QTJzM{[3
GM15850 M1G1Z2tqdmG|ZTDBd5NigQ>? M3j2UFIvPSEQvF2= NYXM[ohVQTZiaB?= M1nLd2ROW09? M{Hte2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTCxOkBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MmDLNVY6OjF|Nke=
U937 MnXiSpVv[3Srb36gRZN{[Xl? M{mwOFUh|ryP NIHreZIzPCCq M4jUPGROW09? NHLGXmlE\WyuIHP5Z4xmKGG{cnXzeEBjgSCjY3P1cZVt[XSrb36gZZQhWy:JMj;NJJBp[XOn MU[xO|AxPDdzOB?=
H661 NXfKcJZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;RWnk1QCCq M{DzdmlEPTB;MTFOwG0> MXixO|E2PzByOR?=
U937 Ml;0SpVv[3Srb36gRZN{[Xl? NXrMfnFRPSEQvF2= M1Lzb|I1KGh? NIr2[FdFVVOR MWDJcoNz\WG|ZTDpckBpcXO2b37lJGg{KGGlZYT5cIF1cW:w M3HOVlE4PDR5N{Ww
U937 NHOy[JRHfW6ldHnvckBCe3OjeR?= MUixJO69VQ>? MmTsNlQhcA>? NFPq[mtFVVOR MnHySYZn\WO2IH;uJIFteGijIIT1ZpVtcW5iYXPleJlt[XSrb36= NX7OSY9lOTd2NEe3OVA>
RAW264.7 M37HfGZ2dmO2aX;uJGF{e2G7 MofGNVAh|ryP NVTYPJd[OjSq MWj3ZZRmeg>? NVLHcYF{UW6qaXLpeIlwdiCxZjDMVHMue3SrbYXsZZRm\CCWTl\hcJBp[SCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAxNjd4IN88US=> MXGxO|Q4PzVzOB?=
RAW264.7 M1G1O2Z2dmO2aX;uJGF{e2G7 MUCxNEDPxE1? Mne0NlRp MkHme4F1\XJ? NEfoeZZKdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKE6RIIDyc4R2[3Srb36ge4l1cCCLQ{WwJI9nKDFwOEig{txO NWXoVZliOTd2N{e1NVg>
SC9 NYPid2F1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELUTlg1QCCq MXzJR|UxRTBwNkC2JO69VQ>? M{S0TlE4PTB5MkG5
ST14A MlTFSpVv[3Srb36gRZN{[Xl? MoPjOUBvVQ>? MnjpO|IhcA>? NITFc3FKdmO{ZXHz[UBqdiCURWPUM25TW0ZibWLORUBmgHC{ZYPzbY9v MYixO|U3PTl7Mx?=
ST14A NV3VUWgyTnWwY4Tpc44hSXO|YYm= MV61JI5O MWO3NkBp NHf5PJlKdmO{ZXHz[UBqdiCHMl[xJI1TVkFiZYjwdoV{e2mxbh?= M{PwR|E4PTZ3OUmz
PANC1 M1W4dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1G0[VEh|ryP M3nPNmlEPTB;MD60OUDPxE1? NGfQTXMyPzV6OEe0OC=>
PANC1 NXLDNIU2TnWwY4Tpc44hSXO|YYm= NF[xdXEyKM7:TR?= NF;QWlMzPCCq NFzpRW1KdmO{ZXHz[UBqdiCyMkHXRWYyN0OLUEGg[4Vv\SCneIDy[ZN{cW:w NH\jfXMyPzV6OEe0OC=>
PANC1 M3GxZmZ2dmO2aX;uJGF{e2G7 NHPVR4gyKM7:TR?= MXuyOEBp NYnFO|VnUW6lcnXhd4UhcW5icEK3b4lxOSCpZX7lJIV5eHKnc4Ppc44> MYqxO|U5QDd2NB?=
PT45 MmHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1SzeGlEPTB;NDFOwG0> M3\hfVE4PTh6N{S0
ACHN M1jWT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlW1NlEhcA>? Ml3pS2k2OD1yLk[1JO69VQ>? MWqxO|Y3OjZyNh?=
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T24 NHT3b|VMcW6jc3WgRZN{[Xl? Mn3BN{Bp MYnJcoR2[3Srb36gc4YhcGm|dH;u[UBJOyCjY3X0fYxifGmxbjD3bZRpKEWFNUCgc4YhOC5zMjFOwG0> MoHINVkxQDR|OUW=
T24 NF\kO5NMcW6jc3WgRZN{[Xl? MmrFN{Bp MkL4TY5lfWO2aX;uJI9nKGGucHjhJJR2[nWuaX6gZYNmfHmuYYTpc44hf2m2aDDFR|UxKG:oIECuNlUh|ryP M2jINVE6ODh2M{m1
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DMS114 Mlj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXsT|g1QCCq MnHaS2k2OD1{Lkmg{txO M{\mVFE6PDF7MkC1
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CAL27 NHLkb3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfhO|IhcA>? M4C1VmlEPTB;Mz63NkDPxE1? M4jydlIxOTR|N{e4
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NCI-H2122 NEL6fY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jZOFczKGh? NHnlcpFKSzVyPUeuOUDPxE1? MXiyNFE1Ozd5OB?=
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SCC25 MkjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYi3NkBp NXPYcZZMUUN3ME2xMlk{KM7:TR?= NIj2[XkzODF2M{e3PC=>
SKHEP1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHJO|IhcA>? NEK5emdKSzVyPUOuOFYh|ryP MUCyNFE1Ozd5OB?=
BJ NHnnToNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX61XYR6OTByIN88US=> MnHmOFghcA>? MXzEUXNQ MmLWS5Jwf3SqIHnubIljcXSrb36gZZQhOC5yNTD0c{AyODBidV2= M3vnfVIxOTR|OESw
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Caco-2 M4nk[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXuxNFAh|ryP NVra[WhyPDiq M1T3e2ROW09? NEH6ZZBKSzVyPUiuNUDPxE1? M2TEWVIxOTR|OESw
Caco-2 M3v5OmtqdmG|ZTDBd5NigQ>? MorjOUDPxE1? M37ES|QhcA>? NWTQUGRHTE2VTx?= NWrObpVSUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhcGm|dH;u[UBi[2W2eXzheIlwdiCLQ{WwJI9nKDBwMEO3JO69VQ>? M3vkOlIxOTR|OESw
Caco-2 MkPHT4lv[XOnIFHzd4F6 MlzWNE4{OTZibl2geI8hOzFwNjFOwG0> NX\FSnM2PCCq NVWwSYpiTE2VTx?= MnnSSZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUNzIIfpeIghUUN3MDDv[kAxNjFzOTFOwG0> MUCyNFE1Ozh2MB?=
Caco-2 M4D3W2tqdmG|ZTDBd5NigQ>? MUewMlMyPiCwTTD0c{A{OS54IN88US=> M{f4dVQhcA>? NXzXXYJ2TE2VTx?= MlLWSZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN|IIfpeIghUUN3MDDv[kAxNjF2NzFOwG0> NUL6VVlOOjBzNEO4OFA>
Caco-2 MXHLbY5ie2ViQYPzZZk> M{\2eFYvOzJibl2geI8hPjN{IN88US=> NVzjOHg{PCCq M1\KTWROW09? Mmr1SZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN3IIfpeIghUUN3MDDv[kAyOi54IN88US=> NHXmcW4zODF2M{i0NC=>
Caco-2 NGPFb25McW6jc3WgRZN{[Xl? NGmwZ2M3NjN{IH7NJJRwKDZ|MjFOwG0> NY\5WoxnPCCq M33oeGROW09? NFSydXBGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{ege4l1cCCLQ{WwJI9nKDRzIN88US=> M2HLS|IxOTR|OESw
Caco-2 MkjoT4lv[XOnIFHzd4F6 M3XhU|AvOzF4IH7NJJRwKDNzLk[g{txO NWnwS5RjPCCq Mk\6SG1UVw>? NEjueI5GgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{[= MXSyNFE1Ozh2MB?=
HepG2 NGDZfWZMcW6jc3WgRZN{[Xl? NYK1SJh{PSEQvF2= MXO2bC=> MlHTSG1UVw>? NXzxUHhPUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhcGm|dH;u[UBi[2W2eXzheIlwdg>? NW\xT2xGOjBzNEO4OFA>
HepG2 NI\OWYhMcW6jc3WgRZN{[Xl? MUG1JO69VQ>? NIXkbXk3cA>? MnXWSG1UVw>? NVzyT|VJUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhcGm|dH;u[UBpgXCncnHj[ZR6dGG2aX;u MXeyNFE1Ozh2MB?=
HepG2 Ml7JT4lv[XOnIFHzd4F6 NWL3UXJyPSEQvF2= M3e3clZp M1roeGROW09? NIjqWIdKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBidHCqYT30eYJ2dGmwIHHj[ZR6dGG2aX;u Mnz3NlAyPDN6NEC=
HepG2 NGfCNndMcW6jc3WgRZN{[Xl? MYO1JO69VQ>? NVvZdWFIPmh? NYHxXI1{TE2VTx?= NFHWcGpKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBJOy:KNDDobZN1d26nIHHj[ZR6dGG2aX;u MkDPNlAyPDN6NEC=
COLO205 MWTLbY5ie2ViQYPzZZk> MoTuNVAh|ryP Mle5NlQhcA>? MoTKSG1UVw>? M17ZfmlvcGmkaYTpc44hd2ZiSFTBR|Eh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIhqe3SxbnWgTFMh[WOndInsZZRqd25id3n0bEBKSzVyIH;mJFIvOiEQvF2= M4rENFIxPDVzM{e4
SCC4 NYm4NGtiU2mwYYPlJGF{e2G7 M4q2d|Eh|ryP NVHocYpNOjSq NWHB[pdKUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJJR2[nWuaX6gZYNmfHmuYYTpc44> MYCyNFQ2OjJ{NR?=
SCC4 M2m5b2tqdmG|ZTDBd5NigQ>? NUHqVJFOOSEQvF2= M2TCO|I1cA>? NGrL[GFKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDhZ4V1gWyjdHnvci=> NHv2XWczODR3MkKyOS=>
SCC4 M1zVdGZ2dmO2aX;uJGF{e2G7 NIeyWmgyKM7:TR?= MknhOUBucW5? NUD0[5pbSWexbnnzeEBi[3Srdnn0fUBifCCYRGKgZZN{\XO|ZXSgZZMhcW6mdXP0bY9vKG:oIFPZVFI1KGenbnWg[ZhxemW|c3nvci=> MY[yNFQ2OjJ{NR?=
NB4 NXHD[4hUTnWwY4Tpc44hSXO|YYm= MYW1JO69VQ>? Mnu1NlQhcA>? MnvsSG1UVw>? MWnD[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCjY3P1cZVt[XSrb36gZZQheHKnLVexJJBp[XOn NEeyZ2gzODR7MUS0NC=>
NB4 NYjabIN1U2mwYYPlJGF{e2G7 MkTHOUDPxE1? NH7SWWgzPCCq MXvEUXNQ M2HYTGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDhZ4V1gWyjdHWgeJVjfWyrbjDs[ZZmdA>? NI\hW|czODR7MUS0NC=>
NB4 MUXGeY5kfGmxbjDBd5NigQ>? NInqWJc2KM7:TR?= MlrsNlQhcA>? MXHEUXNQ NILQ[4RKdmS3Y4Tpc44hd2ZicEKxW2FHOS:FSWCxJIV5eHKnc4Ppc44> NV72S45iOjB2OUG0OFA>
NB4 MmjzT4lv[XOnIFHzd4F6 NXXRV2w{PSEQvF2= M3PmWFI1KGh? NWraOHV7TE2VTx?= NVH4VZRpUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMh[WOndInsZZRqd25? MkPvNlA1QTF2NEC=
NUGC3 NVvIe25iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnhS4JVT0l3ME2yMlk1KM7:TR?= NVHtNZMyOjB6NUC5O|E>
A549 NHzzTmFHfW6ldHnvckBCe3OjeR?= MV:1JO69VQ>? NFj4bXM{KGh? M{LvS2ROW09? MYTJcoR2[3Srb36gc4Yh[XW2b4DoZYd6KGmwIHj1cYFvKEF3NEmgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hVEN|SVm= MVKyNFg2PTJyOB?=
HUT78 NVqwc2YxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn23O|IhcA>? MXnEUXNQ M2KyVGdKPTB;MD6zJO69VQ>? NIrEU4QzODh6NEKwPC=>
U937 M4DzV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPNOIJyPzJiaB?= MX\EUXNQ M2K5VmdKPTB;MD6zPUDPxE1? NELWN5MzODh6NEKwPC=>
A431 M4HzWGN6fG:2b4jpZ{BCe3OjeR?= NUDjRmpVPzJiaB?= MoPFR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVQ{OSClZXzsd{BwfmW{ZYjwdoV{e2mwZzDFS2ZTKHerdHigTWM2OCCxZjC0MlIh|ryP NX\DNJoxOjFyOEC2Nlk>
A549 NVW2eHBHS3m2b4TvfIlkKEG|c3H5 NXHTW2N6PzJiaB?= MkX0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISGFEKHerdHigTWM2OCCxZjCxMlgh|ryP M1vNVlIyODhyNkK5
CAL27 MWTDfZRwfG:6aXOgRZN{[Xl? NILkTWg4OiCq NH3FcIxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBESUx{NzDj[YxteyCxdnXy[ZhxemW|c3nu[{BGT0[UIIfpeIghUUN3MDDv[kA{NjJizszN NFvyVnYzOTB6ME[yPS=>
HeLa NH:4[XJEgXSxdH;4bYMhSXO|YYm= NYrrbGRSPzJiaB?= NXq5S2VsS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTEGFIIfpeIghUUN3MDDv[kAyNjVizszN MVKyNVA5ODZ{OR?=
Sf21 MojwT4lv[XOnIFHzd4F6 Mmn5N{Bp NF3uenFKdmirYnn0bY9vKG:oIF\sZYchfGGpZ3XkJIh2dWGwIILlZ49u[mmwYX70JGhFSUN6IHX4dJJme3OnZDD3bZRpKEmFNUCgc4YhOS5{IN88US=> NGP2ZYgzOTB6ME[yPS=>
SKBR3 MlrBR5l1d3SxeHnjJGF{e2G7 NGTlPXY4OiCq NFXsfXVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0KUMzDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTVJ{IIfpeIghUUN3MDDv[kAzNjZizszN M1jLUFIyODhyNkK5
SKOV3 MY\DfZRwfG:6aXOgRZN{[Xl? NGfEb3g4OiCq MVLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT29XOyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISXIzKHerdHigTWM2OCCxZjCyMlIh|ryP Mn3nNlExQDB4Mkm=
COR-L23 MlrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;qNVAh|ryP M1vFclczKGh? NHXTRVZFVVOR NXXwO2l6T0l3ME2xMlEh|ryP M{nZUVIyODhyNkS3
DU145 M4jqfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX[xNEDPxE1? NFvSZoc4OiCq NH2yV4xFVVOR NEnlVnNIUTVyPUGuNFUh|ryP NFXuRVczOTB6ME[0Oy=>
LoVo NGjhOYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvURVJlOTBizszN NIHtcYI4OiCq NGPSUXRFVVOR M3e2fGdKPTB;MT63JO69VQ>? MkfaNlExQDB4NEe=
MCR5-SV2 NHn5WYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3SfXMyOCEQvF2= MUO3NkBp MVrEUXNQ NF;D[WNIUTVyPUKuNUDPxE1? Mm\QNlExQDB4NEe=
HCT116 NHjzNGNMcW6jc3WgRZN{[Xl? M2e0SlMxKM7:TR?= M{j0U|MxKGh? Ml[wSG1UVw>? MWrJcohq[mm2aX;uJI9nKEiGQVO2JIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDhcJBp[S22dXL1cIlvKGGlZYT5cIF1cW:w M3\tZlIyODhyNkS3
HCT116 M1rBd2tqdmG|ZTDBd5NigQ>? NV3BU|JxOzBizszN MXqzNEBp NEfTWpRFVVOR MmHRTY5pcWKrdHnvckBw\iCKRFHDNUBie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gbIl{fG:wZTDIN2s6KGGlZYT5cIF1cW:w NWTYSpBFOjFyOEC2OFc>
U937 NV[xcZRJU2mwYYPlJGF{e2G7 MnP3OUDPxE1? M4C2fVI1KGh? M{XVXGROW09? MXvJcohq[mm2aX;uJI9nKGirc4TvcoUh[WOndInseJJidnOoZYLhd4Uh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[gZYNmfHmuYYTpc44hd2ZiaHnzeI9v\SCKMzDheEBMQQ>? NWj6Xm5{OjF{OUK0PVI>
U937 M{CyeGtqdmG|ZTDBd5NigQ>? Ml\POUDPxE1? M2TLVVI1KGh? MXnEUXNQ NV;EXHFpUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{G4 MXmyNVI6OjR7Mh?=
U937 NITTO4RMcW6jc3WgRZN{[Xl? M1u3e|Uh|ryP MYWyOEBp M3O2VGROW09? NHnuZWVKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4YheGGwLXHj[ZR6dGG2ZXSgbIl{fG:wZTDIOEBt\X[nbB?= MlHpNlEzQTJ2OUK=
U937 NF;HXVNMcW6jc3WgRZN{[Xl? MXG1JO69VQ>? NGDiRpkyPSCvaX6= NXTDW2hYTE2VTx?= M2rOOmlvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBpcXO2b37lJGg{KGGlZYT5cIF1cW:wIHzleoVt M2fBPFIyOjl{NEmy
A2780 NEPJfJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7DPVYhcA>? MmTKSG1UVw>? MV;JR|UxRTFwNkKg{txO NEHkO5AzOTZ|NESzNC=>
COLO205 M4\QOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfFPVYhcA>? NFz6TVJFVVOR NF\aUZRKSzVyPUKuNVIh|ryP NUj2boRTOjF4M{S0N|A>
Hep3B MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXX3fXNxPDhiaB?= M1\ReGROW09? M4PpPGdKPTB;MT6yNUDPxE1? MUWyNVcyOjF2Nh?=
GM11272 NUDRfYNDTnWwY4Tpc44hSXO|YYm= MUCxNFAhdk1? NGDnXoQ4OiCq MnywSG1UVw>? MYrS[YFkfGm4YYTpc44hd2ZiTXXDdFIhdXW2YX70JIV5eHKnc4Ppc44h[XRiMUCgeI8hOTByIH7N NETQSI4zOTh2MEexOi=>
CFBE41o NHO3fppMcW6jc3WgRZN{[Xl? M2Oyd|Uh|ryP MYHEUXNQ M4jafmRwf25icnXneYxifGmxbjDv[kBJTEGFNzDheEAxNjJidH:gOUB2VQ>? MlPKNlE6QDR7NUi=
CFBE41o M1i1VGZ2dmO2aX;uJGF{e2G7 MlTQNUDPxE1? MlLBNlQhcA>? MlHiSG1UVw>? NYGxV5FZWmW|dH;yZZRqd25ib3[gR2ZVWiCmZXz0ZWY2ODhibYX0ZY51KHS{YX\mbYNscW6pIITvJINmdGxic4Xy[oFk\SCjczDncJlkd2[xcn3z M4Tnd|IyQTh2OUW4
DU145 MnTqT4lv[XOnIFHzd4F6 NVLVXW1IOi53IN88US=> MVyyOEBp MXnEUXNQ MWrJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhfXC{ZXf1cIF1cW:wIH;mJJAzOXejZkGgdJJwfGWrbjDlfJBz\XO|aX;u M1GweFIzOjZyMU[2
DU145 NWLzU3RVU2mwYYPlJGF{e2G7 M1PqZlUh|ryP NX3j[2ltOjRiaB?= MXXEUXNQ NWr3N3l2UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHjpd5RwdmViSESgZYNmfHmuYYTpc44> NFuyOFIzOjJ4MEG2Oi=>
DU145 MmnJT4lv[XOnIFHzd4F6 NUO3XGQ{PSEQvF2= NUL0fWtuOjRiaB?= Mnn5SG1UVw>? MoLBTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGirc4TvcoUhUDNiaInw[ZJi[2W2eXzheIlwdg>? MknUNlIzPjBzNk[=
786-0 MlXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zVV|YvOiEQvF2= NG\HeWM4OiCq NHGzN4RFVVOR NUS1XoxXT0l3ME2zMlIh|ryP NYK2cpdyOjJ2M{W2Olk>
A498 MnPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWi2MlIh|ryP NGfNSXQ4OiCq NVnXVWlXTE2VTx?= MoGxS2k2OD1zLk[g{txO MknZNlI1OzV4Nkm=
A549/ATCC M3XCfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4mxUlYvOiEQvF2= NEOyfoo4OiCq M4PabWROW09? NE\2fIVIUTVyPUGuOkDPxE1? NInUcHYzOjR|NU[2PS=>
ACHN NEH6dWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkP6Ok4zKM7:TR?= NV;PeZExPzJiaB?= M2O5W2ROW09? NHSzeJdIUTVyPUGuN{DPxE1? M{n6fVIzPDN3Nk[5
BT549 M2TibGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlixOk4zKM7:TR?= MmSyO|IhcA>? MljaSG1UVw>? NYPNcIRNT0l3ME2xMlMh|ryP MlPLNlI1OzV4Nkm=
EKVX MmDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHr2TGs3NjJizszN MUO3NkBp MnK4SG1UVw>? NFK2cpBIUTVyPUGuN{DPxE1? MmXQNlI1OzV4Nkm=
HCT15 MkTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU[2MlIh|ryP MXK3NkBp MoTOSG1UVw>? Ml2xS2k2OD1{LkWg{txO MkfLNlI1OzV4Nkm=
HOP92 NFfVSpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PFUVYvOiEQvF2= MWi3NkBp MWLEUXNQ M4C3eGdKPTB;NDFOwG0> NW\OW5ljOjJ2M{W2Olk>
IGROV1 NGLv[3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPOOk4zKM7:TR?= NXm4e5BHPzJiaB?= M33LN2ROW09? MYDHTVUxRTFwMzFOwG0> MlK4NlI1OzV4Nkm=
LOXIMVI NX;OV|NET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnvOk4zKM7:TR?= NFTEZ3E4OiCq NFG4WmhFVVOR M4e3eWdKPTB;MTFOwG0> NELmNWUzOjR|NU[2PS=>
M14 NHrCfXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDGbXUzPi5{IN88US=> M4\6blczKGh? NY[2NnJTTE2VTx?= M3:xXmdKPTB;MT6zJO69VQ>? MkDvNlI1OzV4Nkm=
MALME-3M NWPOcnFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrkR|k3NjJizszN MoTXO|IhcA>? NVTHUFBFTE2VTx?= Mn;6S2k2OD1yLkOyJO69VQ>? NH3CZ4MzOjR|NU[2PS=>
MCF10A NF3zUIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzYOk4zKM7:TR?= MoK0OFghcA>? NH3RPFBFVVOR NUfWNYpsT0l3ME25MlYh|ryP MnfCNlI1OzV4Nkm=
MDA-MB-435 M3jN[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPuSpU3NjJizszN NF3oelQ4OiCq MULEUXNQ MmTLS2k2OD1yLkWg{txO M{DZd|IzPDN3Nk[5
MDA-MB-468 NFnQUpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TKeVYvOiEQvF2= NFvVWZg4OiCq M{OzU2ROW09? MUjHTVUxRTBwNkOg{txO MYeyNlQ{PTZ4OR?=
MOLT4 MmLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrBO|h7Pi5{IN88US=> MX:3NkBp M1T3emROW09? MXnHTVUxRTBwNDFOwG0> NGrIbGYzOjR|NU[2PS=>
NCI-ADR-RES NVnWbWF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDNb2o3NjJizszN Ml[zO|IhcA>? NYjuOHVSTE2VTx?= M3jZcWdKPTB;MD6xOkDPxE1? NWHQ[mM{OjJ2M{W2Olk>
NCI-H23 NF\JcVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfPcIg3NjJizszN MmHaO|IhcA>? NUG2ZWRVTE2VTx?= MUjHTVUxRTFizszN MmDINlI1OzV4Nkm=
NCI-H322M NGjWNWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYS2e3ZMPi5{IN88US=> NH\Fc444OiCq NX6yOVJVTE2VTx?= NEXzeldIUTVyPUCuO|kh|ryP NELZUmwzOjR|NU[2PS=>
NCI-H460 M{D0dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHe2Z|g3NjJizszN M{exVFczKGh? MoDQSG1UVw>? MXTHTVUxRTBwN{mg{txO NVjU[4ZYOjJ2M{W2Olk>
NCI-H522 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHjc4Y3NjJizszN M{X2PVczKGh? Mmf2SG1UVw>? M2T2cGdKPTB;MD61JO69VQ>? MoTZNlI1OzV4Nkm=
OVCAR3 MnHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVW2MlIh|ryP NG\nNlY4OiCq NFvtSXhFVVOR NH\jNopIUTVyPUGuN{DPxE1? MVqyNlQ{PTZ4OR?=
OVCAR4 NGTzcoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHL3SZg3NjJizszN M1rIZVczKGh? MlTzSG1UVw>? MmPIS2k2OD12IN88US=> NUXyd5YzOjJ2M{W2Olk>
OVCAR5 NIGyUnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[w[5VvPi5{IN88US=> Mn7SO|IhcA>? MoTUSG1UVw>? M2DZbWdKPTB;MD63PUDPxE1? M17zWVIzPDN3Nk[5
OVCAR8 Ml;VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV62MlIh|ryP M4f1SFczKGh? NFzNeGdFVVOR MVfHTVUxRTBwNTFOwG0> NID0XG4zOjR|NU[2PS=>
RXF393 MkPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTSdoc3NjJizszN MYK3NkBp NGG3V|FFVVOR M2rj[2dKPTB;MT6zJO69VQ>? NWrIWZJzOjJ2M{W2Olk>
SF268 M{nTbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV[2MlIh|ryP NIP0bpk4OiCq MnL1SG1UVw>? MXrHTVUxRTFwNjFOwG0> MXyyNlQ{PTZ4OR?=
SF295 MojFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DK[|YvOiEQvF2= MmjiO|IhcA>? NY\4W2hZTE2VTx?= M3jnfmdKPTB;MT62JO69VQ>? NVThOJl1OjJ2M{W2Olk>
SF539 MlPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmKwOk4zKM7:TR?= M1nHZ|czKGh? M3:ySWROW09? Mnn1S2k2OD1{IN88US=> NWWzPYl{OjJ2M{W2Olk>
SK-MEL-2 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rIUVYvOiEQvF2= NX61cJZRPzJiaB?= MmrZSG1UVw>? MVzHTVUxRTFwMzFOwG0> M2fBUlIzPDN3Nk[5
SK-MEL-28 M1rKNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXHXWI3NjJizszN MmnqO|IhcA>? MkWzSG1UVw>? M3fK[mdKPTB;MTFOwG0> NWm4WGdEOjJ2M{W2Olk>
SK-MEL-5 NHzxN|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUixcZV[Pi5{IN88US=> M2PUOlczKGh? MWLEUXNQ NYPUSmo5T0l3ME2wMlY{KM7:TR?= Mm\SNlI1OzV4Nkm=
SKOV3 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfNO|Z6Pi5{IN88US=> MmfaO|IhcA>? MlHkSG1UVw>? Mm\LS2k2OD1zIN88US=> MmPzNlI1OzV4Nkm=
SN12C MkDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXG2MlIh|ryP MoLTO|IhcA>? M3zyW2ROW09? M1TJNGdKPTB;MjFOwG0> M3fk[VIzPDN3Nk[5
SNB19 M{TxUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTnOk4zKM7:TR?= MoLDO|IhcA>? MUnEUXNQ Ml3FS2k2OD1yLk[zJO69VQ>? Mo\lNlI1OzV4Nkm=
SNB75 M4jlSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHWNVdWPi5{IN88US=> M4LUWVczKGh? M1ixR2ROW09? M2C2bWdKPTB;MD63PUDPxE1? NGm2WnczOjR|NU[2PS=>
SR NWTqdZA2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4f4V|YvOiEQvF2= M4DJWVczKGh? M1G1VmROW09? M33zZmdKPTB;MD60JO69VQ>? M4HiT|IzPDN3Nk[5
T47D M1radWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzQOk4zKM7:TR?= M{TSfVczKGh? NVXJWYZqTE2VTx?= NFzIR4dIUTVyPUCuOUDPxE1? NGPzfG8zOjR|NU[2PS=>
TK10 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rmT|YvOiEQvF2= MmfrO|IhcA>? M{PKdGROW09? NGTzRYZIUTVyPUCuOlMh|ryP MlLhNlI1OzV4Nkm=
UACC257 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XBWVYvOiEQvF2= M2fYblczKGh? NWW0U4FUTE2VTx?= NIfTW4VIUTVyPUCuOUDPxE1? M4X5S|IzPDN3Nk[5
UACC62 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUm2MlIh|ryP M2\5RVczKGh? Mn\DSG1UVw>? NXzwZ4dQT0l3ME2wMlQh|ryP MWSyNlQ{PTZ4OR?=
UO31 NWjoOoN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVO2MlIh|ryP NGPvd|U4OiCq NITu[3FFVVOR NYjBdXNpT0l3ME2wMlUh|ryP NF\1coczOjR|NU[2PS=>
Hep3B NYLueHMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlf4OFghcA>? M1TG[WROW09? NVHEbGhiT0l3ME2wMlY6KM7:TR?= NVjpbGVFOjJ2M{m4OlM>
BE(2)-C M33YWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zLW|czKGh? MkXqSG1UVw>? M3PjfWlEPzB;MjFOwG0> NGrlcXUzOjl|MkOxOi=>
Bel7402 NXHhPGEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;FNFczKGh? NV3QeIJ1TE2VTx?= M1PHPWdKQTB;MUeg{txO MVqyN|A3OTN5Nh?=
Bel7404 NGLSdVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXifVlGPzJiaB?= M2HicGROW09? MUPHTVkxRTF6IN88US=> MkntNlMxPjF|N{[=
BGC823 NFXMOlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XqcFczKGh? NVLLWWlnTE2VTx?= M{DEPWdKQTB;Nz61JO69VQ>? NEfHUYYzOzB4MUO3Oi=>
MGC803 NViyd5l5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmntO|IhcA>? MUDEUXNQ M{\jOWdKQTB;MUCuPEDPxE1? NUTyTIVIOjNyNkGzO|Y>
SGC7901 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvLSIF3PzJiaB?= NEnhcHlFVVOR MV\HTVkxRTlwNDFOwG0> NWqycXZpOjNyNkGzO|Y>
SKHEP1 NFLaNYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnT0O|IhcA>? MkDBSG1UVw>? NIqyS4dIUTlyPUG3JO69VQ>? NVjPZ3NpOjNyNkGzO|Y>
SMMC7721 M2LJ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnYdoxXPzJiaB?= NXXjZ5dYTE2VTx?= NHnLflBIUTlyPUKwJO69VQ>? NVTVbYhlOjNyNkGzO|Y>
NUGC3 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLtNVAh|ryP NFTPXJpIUT1{Lkm0JO69VQ>? NWiwToY3OjNzNkOzN|I>
A2780 CisR NVnRbmN2U2mwYYPlJGF{e2G7 NUTEbpRDOThiaB?= NVjLeldOUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlQ1KM7:TR?= MX6yN|I2OjZyMx?=
CAL27 sens NVHDNm9oU2mwYYPlJGF{e2G7 NX;ueJdMOThiaB?= M13tN2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD6zOkDPxE1? NIe3XXMzOzJ3Mk[wNy=>
CAL27 CisR NF3pbWhMcW6jc3WgRZN{[Xl? NWHLdXY1OThiaB?= NHPsS4xKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOlEh|ryP MVqyN|I2OjZyMx?=
KYSE-510 CisR Mne4T4lv[XOnIFHzd4F6 NYDDcppFOThiaB?= NUCwd5ZrUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlU6KM7:TR?= NEjmUZYzOzJ3Mk[wNy=>
KYSE-510 sens NXHsPFZVU2mwYYPlJGF{e2G7 NIXFR4kyQCCq NI\kOZdKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuO{DPxE1? M2fMeVI{OjV{NkCz
MDA-MB-231 sens M4riO2tqdmG|ZTDBd5NigQ>? NF23RXgyQCCq NVHZZWlsUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?= Mm\SNlMzPTJ4MEO=
MDA-MB-231 CisR MXjLbY5ie2ViQYPzZZk> NF;5[WMyQCCq NUPtcFVTUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?= NIfpcpAzOzJ3Mk[wNy=>
ES2 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzwOFghcA>? MWfEUXNQ MYTJR|UxRTF{Lkeg{txO M2DieVI{PDl|NES5
MDA-MB-231 NWT5OmxWU2mwYYPlJGF{e2G7 NX\IbYw5OTBizszN MV:zNEBucW5? NVO1XoNsTE2VTx?= NIT1bYJKdmirYnn0bY9vKG:oIFjERWMz[Q>? M{\NRlI{PDl|NES5
MDA-MB-231 NEPqdWtMcW6jc3WgRZN{[Xl? M2PWflEh|ryP M3PHZVI1KGh? MnjsSG1UVw>? MmfITY5pcWKrdHnvckBw\iCKRFHDOkBie3Onc4Pl[EBieyCjY3X0fYxifGmxbjDs[ZZmdHNib3[geJVjfWyrbh?= Mo\TNlM1QTN2NEm=
HS68 MlTXR5l1d3SxeHnjJGF{e2G7 Mnf5NVAh|ryP NVm1XFB1PzJiaB?= NWPZRpVNTE2VTx?= MULJR|UxRTRwNjFOwG0> NW\4RYg1OjN3N{C1OFI>
MEF NUPJfWhNS3m2b4TvfIlkKEG|c3H5 NIXkc3UyOCEQvF2= M3jQcFczKGh? NGLBXnFFVVOR NXTHR3BtUUN3ME20MlQh|ryP MkLGNlM2PzB3NEK=
BGC823 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLvSG1UVw>? M4[3VWdKPTB;Mz6wPUDPxE1? NFfnOHAzOzZyMUewOi=>
High5 Mn33T4lv[XOnIFHzd4F6 NV;MSmI5OjRiaB?= MVHJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVO2JJdqfGhiSVO1NEBw\iByLkC5JO69VQ>? MlfZNlM3ODJ3MkO=
High5 NEXrNHNMcW6jc3WgRZN{[Xl? M4HPU|I1KGh? MYLJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVOxJJdqfGhiSVO1NEBw\iByLkGyJO69VQ>? M4HqOFI{PjB{NUKz
High5 NY\5V2pnU2mwYYPlJGF{e2G7 Ml3zNlQhcA>? NFfZWnRKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM{KHerdHigTWM2OCCxZjCwMlE4KM7:TR?= NWPZfYhWOjN4MEK1NlM>
A549 M{K1d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfEUXNQ NW\lS483UUN3ME2xMlA4QSEQvF2= Moj5NlM3PDR{MUC=
HCT116 M3rJVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{D3RmROW09? NXrZcGF3UUN3ME2wMlc2PyEQvF2= NG\hfXozOzZ2NEKxNC=>
K562 NHuwVI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1j4OWROW09? NUO4SW93UUN3ME2wMlY1PSEQvF2= NYL2O5FROjN4NESyNVA>
GBC-SD MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTYXXo2KM7:TR?= MXu3NkBp NIfZV2tFVVOR MnLoTWM2OD1zND64JO69VQ>? MVKyN|cxPzJ4MB?=
HGC27 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETo[WI2KM7:TR?= NWfQXZhuPzJiaB?= MUnEUXNQ M2rJU2lEPTB;NT60JO69VQ>? M3rBc|I{PzB5Mk[w
HL60 MUTLbY5ie2ViQYPzZZk> NG[3cmM2KM7:TR?= M4rwVlI1KGh? Mn\OSG1UVw>? NYHnRmlyUW6qaXLpeIlwdiCxZjDISGFE MlXINlM4ODd{NkC=
Vero MnHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFi5d5c4OiCq MmHiSG1UVw>? M4LUTmlEPTB;MD65JO69VQ>? NEX1SG8zOzd6NkS1Ni=>
NCI60 NXfGe2szS3m2b4TvfIlkKEG|c3H5 NWGzWFBrPDhiaB?= MW\EUXNQ MUDHTV0xNjV|IN88US=> NVzydYtiOjRyMUWzNlc>
SW620 MWjDfZRwfG:6aXOgRZN{[Xl? MYC0PEBp MmjqSG1UVw>? NU[3PZZST0l;MD61OEDPxE1? NUfjS4tDOjRyMUWzNlc>
U251 NUDIb|dwS3m2b4TvfIlkKEG|c3H5 MX20PEBp MojPSG1UVw>? MXnHTV0yNjV|IN88US=> NF7XZYUzPDBzNUOyOy=>
KM12 M{ixfmN6fG:2b4jpZ{BCe3OjeR?= M4C5XlQ5KGh? MkTZSG1UVw>? NWjC[IxoT0l;MT64PEDPxE1? NEDjZXczPDBzNUOyOy=>
Hs578T NHW4U|FEgXSxdH;4bYMhSXO|YYm= NVPyU41KPDhiaB?= NVS0XlF7TE2VTx?= NWi0SnEzT0l;ND64N{DPxE1? NHPES4IzPDBzNUOyOy=>
MDA-MB-231 NWTCVIloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnOO2E1QCCq Ml2xTWM2OD1yLkG2JO69VQ>? NVXXbmtSOjRyOUWwNVY>
MCF7 NGXlWI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFn3THo1QCCq NIn6TJlIUT1yLkS1JO69VQ>? MoPCNlQyOTl3NUW=
MDA-MB-435 MkXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDsZpg1QCCq NVjhUIdQT0l;MD64PEDPxE1? MWOyOFEyQTV3NR?=
AsPC1 MmPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHvN|Ah|ryP MYq0PEBp NFLHWpNFVVOR MV7JR|UxRTNwNk[g{txO NY\GUlRzOjRzOEWzO|g>
Jurkat E6.1 MoDuT4lv[XOnIFHzd4F6 M4LkdFIhcA>? Mmm2SG1UVw>? MoTCTY5pcWKrdHnvckBw\iCKRFHDOEB4cXSqIFnDOVAhd2ZiMD6wOEDPxE1? NV7K[ZdMOjR{NkG4OlI>
KG1 M1i0eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYe0PEBp MkLMTWM2OD1zLkG1JO69VQ>? MWCyOFUzPTByMx?=
HEL MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rqNlQ5KGh? NV6xZWxjTE2VTx?= M4HDb2lEPTB;MD60PUDPxE1? NGDJdlEzPDZ7NEC1OS=>
HSC3 M{PaRWN6fG:2b4jpZ{BCe3OjeR?= MnjCNVIhcA>? NWfZSnc5TE2VTx?= NVvwVmFpUUN3ME2wMlcyKM7:TR?= NFfST4szPDd4NkW2NC=>
HT-29 NHTXPFNEgXSxdH;4bYMhSXO|YYm= MmewNVIhcA>? NWDSNYFTTE2VTx?= M{SxSWlEPTB;MD63NkDPxE1? M4nMdVI1PzZ4NU[w
KB MV7DfZRwfG:6aXOgRZN{[Xl? MnflNVIhcA>? NXfqZ3QzTE2VTx?= MYfJR|UxRTBwN{Wg{txO NYHUb|FOOjR5Nk[1OlA>
H460 MmLDR5l1d3SxeHnjJGF{e2G7 NVvOfIJ1OTJiaB?= Moj4SG1UVw>? NVXLUFV[UUN3ME2wMlgzKM7:TR?= M4XCeFI1PzZ4NU[w
MONE1 NXiyfI15S3m2b4TvfIlkKEG|c3H5 NVvvZmI{OTJiaB?= M{CzTGROW09? M2Hj[GlEPTB;MT6xPEDPxE1? NWrwdWQ2OjR5Nk[1OlA>
MKN45 MmDRR5l1d3SxeHnjJGF{e2G7 Mn;6NVIhcA>? Mlj5SG1UVw>? M2S1NGlEPTB;MT6yOUDPxE1? M2fDb|I1PzZ4NU[w
TSGH MnvsR5l1d3SxeHnjJGF{e2G7 M1PuflEzKGh? NWLURmFNTE2VTx?= MU\JR|UxRTJwMEmg{txO MlHHNlQ4PjZ3NkC=
HL60 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvkNHM4OiCq MoDQSG1UVw>? M3HoNWdKPTB;MD65N{DPxE1? NX;PVpI6OjR7MEC1NFA>
HEK293 NXvSe2U4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PZcFczKGh? NGHFSGdFVVOR M1;jU2dKPTB;MUOg{txO NUDiUpVnOjR7MEC1NFA>
Jurkat NWLFSnBWS3m2b4TvfIlkKEG|c3H5 NFG0c|QyODBizszN M2LPdlczKGh? MVfHTVUxRTBwOTFOwG0> MmDQNlQ6ODB5NEO=
GM15850 NFnLV|dMcW6jc3WgRZN{[Xl? M3S3[VIvPSEQvF2= NIjYW4s6PiCq M2m3OmROW09? M2DlSIRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg{KGy7c3nu[UAyPCCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> MkDsNVY6OjF|Nke=
GM15850 MYTLbY5ie2ViQYPzZZk> M1PJ[VIvPSEQvF2= MmLwPVYhcA>? NVXpNYVLTE2VTx?= NI\XNXdld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJPCCueYPpcoUhPSCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> MU[xOlkzOTN4Nx?=
GM15850 NFKzWnFMcW6jc3WgRZN{[Xl? NXriVY9jOi53IN88US=> NUHOSVd5QTZiaB?= Mlf2SG1UVw>? MmTW[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFEzKGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l M170cFE3QTJzM{[3
GM15850 NXPBTGFzU2mwYYPlJGF{e2G7 MVGyMlUh|ryP M3Ozblk3KGh? M2rxNmROW09? NULMTlQy\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDNibInzbY5mKDliYXPleJlt[XSrb36gc4YhTliQIHflcoU> NWnsbGtQOTZ7MkGzOlc>
GM15850 M3nvcGtqdmG|ZTDBd5NigQ>? NU\T[VVkOi53IN88US=> NF3TXJY6PiCq NXexVoRJTE2VTx?= NHi2Zo5ld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJPCCueYPpcoUhQCCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> NYfi[WkyOTZ7MkGzOlc>
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HSC-4 Mlr2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTh2Nj61NUBvVQ>? M{XpV3NCVkeHUh?=
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SW954 NYLUcoNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fXVWlEPTB;OE[zMlE3KG6P MoPVV2FPT0WU
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NCI-H1092 M1\QOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYi1VXEzUUN3ME2xMlE2PDB4IN88US=> NIj6WZdUSU6JRWK=
EW-3 M{LpN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTFwMUeyNVIh|ryP NVvGSFBSW0GQR1XS
HCT-116 NYHufIZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnEbpo2UUN3ME2xMlE4PzVizszN NVzlVGFLW0GQR1XS
MC-IXC NWnY[XBET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfC[2U1UUN3ME2xMlE4QDhzIN88US=> NEnWSY9USU6JRWK=
LB1047-RCC NH[4V3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlKxTWM2OD1zLkG4N|EzKM7:TR?= NUP2XJp5W0GQR1XS
VM-CUB-1 NUD1WFl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTFwMUmxNFgh|ryP MYPTRW5ITVJ?
NB5 NXrObnc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkT6TWM2OD1zLkG5PFU3KM7:TR?= M2TKV3NCVkeHUh?=
SKG-IIIa NXnhOGt2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3HTWM2OD1zLkKzOFY1KM7:TR?= NVvlOGs1W0GQR1XS
HO-1-N-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHmTWM2OD1zLkKzPFM2KM7:TR?= M1XP[3NCVkeHUh?=
EFO-27 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPCTWM2OD1zLkK1NFQ{KM7:TR?= Ml3BV2FPT0WU
MHH-NB-11 NXrSVGg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWG0TJB[UUN3ME2xMlI5OzJ7IN88US=> M{nkfnNCVkeHUh?=
SW620 NXHrc2dpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTFwMkmwNVgh|ryP NYL3TIhNW0GQR1XS
MOLT-16 MnfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXlTWM2OD1zLkK5O|k4KM7:TR?= MULTRW5ITVJ?
NTERA-S-cl-D1 MkT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PvS2lEPTB;MT6zNVc3OSEQvF2= NXfqcopjW0GQR1XS
VA-ES-BJ NITUSpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vT[WlEPTB;MT6zNlQ4PyEQvF2= NH\M[GtUSU6JRWK=
HCC1419 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnXb2hKSzVyPUGuN|QxOjdizszN NHP3SZJUSU6JRWK=
NCI-H69 NVP4c2Z2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fPXGlEPTB;MT6zOFEyOiEQvF2= Ml3qV2FPT0WU
DEL NYrjUoN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTFwM{WxOlIh|ryP MY\TRW5ITVJ?
LXF-289 MnPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\FTWM2OD1zLkO1NlQh|ryP NIDXUWZUSU6JRWK=
EW-11 M3nRdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLQdVUyUUN3ME2xMlM3ODJ4IN88US=> MXzTRW5ITVJ?
KP-4 MnXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTFwM{ewPFUh|ryP MVnTRW5ITVJ?
NOS-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrJOYJKSzVyPUGuOFEyQTRizszN Mmm3V2FPT0WU
SK-NEP-1 M{fMTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37OTmlEPTB;MT60NVY6OyEQvF2= Mnj1V2FPT0WU
LAMA-84 NEPuUnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTFwNEO5OFUh|ryP M2\3U3NCVkeHUh?=
ES5 M1rHUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3O0eWlEPTB;MT60OFMh|ryP NIXjVpZUSU6JRWK=
HuO9 MoO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\OUYxKSzVyPUGuOFU{PjJizszN NGPvW|RUSU6JRWK=
COLO-684 NXq2S3B2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXPV|BoUUN3ME2xMlQ3OTF6IN88US=> NHvI[pBUSU6JRWK=
EW-24 M{fqdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7jc|dwUUN3ME2xMlQ3PTNzIN88US=> MmXzV2FPT0WU
BV-173 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTFwNEeyPVEh|ryP NW\rXHdLW0GQR1XS
NCI-H1770 NYXDSGNYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3xN3FKSzVyPUGuOFg2OzZizszN MV;TRW5ITVJ?
HuP-T4 M2X2OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvteHdKSzVyPUGuOFk{KM7:TR?= NYrDc2FUW0GQR1XS
TYK-nu M{m1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnFSYdKSzVyPUGuOFk5PTFizszN MY\TRW5ITVJ?
YH-13 M3voWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTFwNEm4PVQh|ryP MVLTRW5ITVJ?
H4 M2jsdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\YVlNjUUN3ME2xMlUxQTF{IN88US=> NFrHXotUSU6JRWK=
OVCAR-8 MmjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTFwNUS0O|ch|ryP MVrTRW5ITVJ?
NCI-H23 NHPBWYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfSTWM2OD1zLkW0OlQ2KM7:TR?= MXnTRW5ITVJ?
ES7 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3mTWM2OD1zLkW0O|c{KM7:TR?= Mnr0V2FPT0WU
COR-L88 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTFwNU[0NlQh|ryP NX3aOlUxW0GQR1XS
TI-73 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHvPHptUUN3ME2xMlU6ODZizszN NELsZmJUSU6JRWK=
RT-112 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkOyTWM2OD1zLkW5Nlg1KM7:TR?= MkXCV2FPT0WU
HuO-3N1 MnPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTFwNUmzPFUh|ryP NFjnc4VUSU6JRWK=
HC-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\QTWM2OD1zLkW5PFY3KM7:TR?= MoPEV2FPT0WU
HT55 MkHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\SbWtJUUN3ME2xMlY2OTNzIN88US=> NUXVOo5CW0GQR1XS
IA-LM NFTtWHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTFUY9KSzVyPUGuOlkzPzhizszN NWDCXGdkW0GQR1XS
EM-2 MnznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTFwN{CwNVQh|ryP MVTTRW5ITVJ?
MHH-ES-1 MmHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfNZpdpUUN3ME2xMlcxPDN3IN88US=> M2PPUHNCVkeHUh?=
CAL-27 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;EXnpxUUN3ME2xMlcxPjJzIN88US=> Mn70V2FPT0WU
COLO-800 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTRXm1EUUN3ME2xMlcyOTd7IN88US=> MULTRW5ITVJ?
HCE-T MmPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLsTWM2OD1zLkexOUDPxE1? MV;TRW5ITVJ?
CAMA-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF6yfJRKSzVyPUGuO|E6PzFizszN NWTIU4FTW0GQR1XS
LOXIMVI NFTtbHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TDRmlEPTB;MT63NlEyKM7:TR?= M3;SeHNCVkeHUh?=
NH-12 M4TONWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTFwN{K2PVEh|ryP MmXtV2FPT0WU
TCCSUP M4Xrfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfBfGdKSzVyPUGuO|I5OjlizszN MYnTRW5ITVJ?
MDA-MB-361 M3rIVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnrcWVKSzVyPUGuO|MyPTdizszN MmjSV2FPT0WU
EW-16 M3\yNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrLTWM2OD1zLke0NVA4KM7:TR?= M2\oU3NCVkeHUh?=
SNU-423 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3STohKSzVyPUGuO|U5OjdizszN M4HYTHNCVkeHUh?=
Daoy NWiweXhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTFwN{[zNVkh|ryP M4TEW3NCVkeHUh?=
ES4 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfCZ5RsUUN3ME2xMlc5PzRzIN88US=> NGT0Oo5USU6JRWK=
PFSK-1 NFn2UIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTFwOECzO{DPxE1? NUPPb3ZtW0GQR1XS
ES3 NUfHcFg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fSSWlEPTB;MT64NlY5OSEQvF2= MmXnV2FPT0WU
ONS-76 NUC0OYpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHMTWM2OD1zLkiyPFk4KM7:TR?= M4m4ZnNCVkeHUh?=
JVM-3 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTFwOEW0OVEh|ryP NX;h[FVEW0GQR1XS
OS-RC-2 Mmq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zKfWlEPTB;MT64O|E2OSEQvF2= M12xWnNCVkeHUh?=
COLO-320-HSR NFjWR2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjJc3dKSzVyPUGuPFgyQTdizszN MlTRV2FPT0WU
HN MmPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\xNo0xUUN3ME2xMlg5PzJ3IN88US=> MmD5V2FPT0WU
HT MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHTepd1UUN3ME2xMlg5QTR5IN88US=> NH;aenRUSU6JRWK=
LoVo M1XWTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPlTWM2OD1zLki5PFEh|ryP NWW0S2lVW0GQR1XS
CGTH-W-1 MorGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzEZWpKSzVyPUGuPFk6PDZizszN NFe5b3JUSU6JRWK=
NB6 M1vnTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFP5OGlKSzVyPUGuPVEzQThizszN MkfXV2FPT0WU
EW-22 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzNPWlKSzVyPUGuPVI5QDdizszN M13KTXNCVkeHUh?=
ES6 M3PzVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTFwOUO2N|Eh|ryP M{XBeXNCVkeHUh?=
SCC-15 NGfPdFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHu2dppKSzVyPUGuPVM5OTlizszN M1rz[HNCVkeHUh?=
HL-60 NXr1UFh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37BbWlEPTB;MT65N|kxOiEQvF2= M4LqenNCVkeHUh?=
human HOP-92 Mn3nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDVeVhrUUN3ME2xMlk1ODZ3IN88US=> NXXEdpM3W0GQR1XS
SW626 MnTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnTdpBZUUN3ME2xMlk1QDl7IN88US=> NG\4VFRUSU6JRWK=
HEC-1 NHf6SIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDG[JNKSzVyPUGuPVU{PiEQvF2= NV;tXXpQW0GQR1XS
LB2241-RCC NFuzRXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HTS2lEPTB;MT65PFI{OSEQvF2= M3HJS3NCVkeHUh?=
Ramos-2G6-4C10 NWXN[ZZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3ruPGlEPTB;MT65PVQ6OyEQvF2= M1POcnNCVkeHUh?=
A101D M37C[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPBNYxKSzVyPUKuNlA{ODNizszN M1Xhe3NCVkeHUh?=
NCI-H446 NYTsOWI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLkTWM2OD1{LkC0OVk6KM7:TR?= M2TRZ3NCVkeHUh?=
SBC-5 M{\ufGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDKTWM2OD1{LkC2NVQ4KM7:TR?= MWTTRW5ITVJ?
HOS NHzsSZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLETWM2OD1{LkC3OlU{KM7:TR?= NW\2VGpkW0GQR1XS
K5 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTJwMEe4NVEh|ryP MXXTRW5ITVJ?
HLE NGq2Wo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjpeHlKSzVyPUKuNFg2OjlizszN M3j6bnNCVkeHUh?=
HSC-2 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TkdWlEPTB;Mj6xNlg6QCEQvF2= MkLDV2FPT0WU
LCLC-97TM1 MlvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHCTWM2OD1{LkG0OVg{KM7:TR?= NITqVVRUSU6JRWK=
DMS-273 NE\XPHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnUW4ZFUUN3ME2yMlE1QDN5IN88US=> Ml\PV2FPT0WU
TE-8 NYPyOVVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPjTWM2OD1{LkG1O|Y2KM7:TR?= MWLTRW5ITVJ?
DSH1 NXPUW5ZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Hac2lEPTB;Mj6xOlM6QCEQvF2= MUjTRW5ITVJ?
CAL-51 M4rlcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjUOoJsUUN3ME2yMlE3Pjl7IN88US=> MWHTRW5ITVJ?
IST-SL1 NGrBTFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTJwMU[4OFQh|ryP NEjFW5NUSU6JRWK=
GCT MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTJwMUe3O{DPxE1? M3y1VnNCVkeHUh?=
SW948 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTmTWM2OD1{LkG4OFU3KM7:TR?= NFPyXJBUSU6JRWK=
NOMO-1 M4P0dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvPSYc4UUN3ME2yMlE6OzF5IN88US=> M{HyZ3NCVkeHUh?=
C8166 MmnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;tVWlEPTB;Mj6yNVM{PCEQvF2= Mnz5V2FPT0WU
OC-314 NHH0bJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLoRZE2UUN3ME2yMlI{OjV7IN88US=> MVzTRW5ITVJ?
CAL-39 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfwbllCUUN3ME2yMlI{PjJ4IN88US=> MnPUV2FPT0WU
MDA-MB-453 NVL6[HU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2i5cmlEPTB;Mj6yOFI4PSEQvF2= MmXNV2FPT0WU
A673 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXmTWM2OD1{LkK1PFYzKM7:TR?= MnXFV2FPT0WU
HTC-C3 NELxfGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXqXmZoUUN3ME2yMlI3QDVizszN M13m[nNCVkeHUh?=
NCI-H1666 NHf4O|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTJwMkixNVEh|ryP MUXTRW5ITVJ?
PSN1 NVHCSpR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTJwMki5NVMh|ryP NUTBZnlCW0GQR1XS
GI-1 NXfoZWpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TJemlEPTB;Mj6zNFU1OyEQvF2= NYTHe2trW0GQR1XS
HuH-7 M4XjPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvjTWM2OD1{LkOwOlM4KM7:TR?= M33WXHNCVkeHUh?=
JAR M3y2WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTJwM{G5PFch|ryP M4PJdnNCVkeHUh?=
5637 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF21e2hKSzVyPUKuN|IyOjlizszN NYfhb|doW0GQR1XS
GB-1 NYrhTGllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHKwTXhKSzVyPUKuN|I{OzVizszN MX3TRW5ITVJ?
KP-N-YS M1XoW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvqTWM2OD1{LkOyOlE2KM7:TR?= MUPTRW5ITVJ?
OAW-42 NXv2SFF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWf3OoJPUUN3ME2yMlM{PDF4IN88US=> M1\kVHNCVkeHUh?=
8-MG-BA NEDp[XhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrXTWM2OD1{LkOzPVA3KM7:TR?= NV:4SJNqW0GQR1XS
RH-18 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTJwM{WwNlIh|ryP M4XI[XNCVkeHUh?=
NCI-H1155 NG\LelJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTJwM{[3NlUh|ryP MYfTRW5ITVJ?
NB17 M1[4e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVL2O49ZUUN3ME2yMlM5OjR|IN88US=> NXvCPWFkW0GQR1XS
NCI-H1437 NX3XTmZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrjOZlDUUN3ME2yMlQyQDd|IN88US=> NEO5SnhUSU6JRWK=
SN12C M2DoVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3wZplRUUN3ME2yMlQ{OjF2IN88US=> NF73SGJUSU6JRWK=
HSC-3 NWDzVVc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTJwNES1NFkh|ryP M{C2[3NCVkeHUh?=
GAMG M{XkU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfob5VKSzVyPUKuOFQ2PjFizszN MW\TRW5ITVJ?
HT-1080 NYfOXW57T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4O2TWlEPTB;Mj60OFg3PCEQvF2= NVrNSHA2W0GQR1XS
A549 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTJwNES4PVMh|ryP NUTIPYV5W0GQR1XS
KNS-62 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTJwNEWwOlEh|ryP M4\mWHNCVkeHUh?=
YKG-1 NWW4bpZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHUZY1KSzVyPUKuOFU1OzdizszN MmjJV2FPT0WU
LU-134-A Mo\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjXXG9zUUN3ME2yMlQ4ODB6IN88US=> M2f3enNCVkeHUh?=
FADU NUS2VGc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TCWWlEPTB;Mj60O|E3OiEQvF2= MUnTRW5ITVJ?
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HT-3 NI\aPFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrLSHljUUN3ME2yMlQ6PTN3IN88US=> NYnKSXh2W0GQR1XS
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EW-13 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTNwNUK1NUDPxE1? NIn3[I1USU6JRWK=
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CAL-62 NH3ZTWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoD4TWM2OD1|LkW0OVE1KM7:TR?= NIjBW45USU6JRWK=
OCUB-M NIHiT5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\PTWM2OD1|LkW0OlY2KM7:TR?= NX7UfmdEW0GQR1XS
BT-474 NEj2OmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPBTWM2OD1|Lk[zN|Eh|ryP M{i1VnNCVkeHUh?=
KYSE-180 NV:3NG12T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXJTWM2OD1|Lk[zN|czKM7:TR?= NV3ub|h{W0GQR1XS
NCI-H650 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTNwNkSyPFch|ryP Ml2wV2FPT0WU
Detroit562 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPC[|JKSzVyPUOuOlUxOjJizszN MofoV2FPT0WU
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Becker NFjmdGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHYOYZTUUN3ME2zMlc2ODF{IN88US=> MUDTRW5ITVJ?
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G-401 Mmj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHORoJ5UUN3ME2zMlc6ODh3IN88US=> NUfnOFRJW0GQR1XS
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D-263MG MljJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTNwOEKwOVEh|ryP M{D3Z3NCVkeHUh?=
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NCI-H1581 M1rhZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fvfGlEPTB;Mz64OFQ5QCEQvF2= NGWxSINUSU6JRWK=
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HCE-4 M1H5fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3P4bWlEPTB;Mz65NVY3OyEQvF2= M3nkeHNCVkeHUh?=
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OVCAR-4 NFPleIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVK4U2ZMUUN3ME2zMlkzQDh7IN88US=> NGTUZmJUSU6JRWK=
ETK-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPHSm1KSzVyPUOuPVQ3OzVizszN MnKxV2FPT0WU
A2780 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfPTWM2OD12LkC1PVY3KM7:TR?= MVrTRW5ITVJ?
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COR-L105 M2fBSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4njN2lEPTB;ND6xN|A2OSEQvF2= Mmq2V2FPT0WU
CAL-12T NGfk[GpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPidlhKSzVyPUSuNVMyODNizszN MYrTRW5ITVJ?
SCH NYrTOHNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHOzO4FKSzVyPUSuNVU4PDNizszN MkjRV2FPT0WU
CW-2 Mln4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MluwTWM2OD12LkG5NFAyKM7:TR?= NWr5UWN3W0GQR1XS
HCC1806 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfKTWM2OD12LkKwN|EzKM7:TR?= M{fa[XNCVkeHUh?=
KP-N-YN MkXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTRwMkC5Nlch|ryP MlvHV2FPT0WU
T98G MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXVTWM2OD12LkKyNVU4KM7:TR?= M2rwTHNCVkeHUh?=
CAL-54 MojGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7K[ZBFUUN3ME20MlIzOzhzIN88US=> MkjWV2FPT0WU
CAL-33 NIntU3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLkPXl1UUN3ME20MlI{ODZ2IN88US=> NHXIdFhUSU6JRWK=
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NUGC-3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXSTWM2OD12LkK1OVA2KM7:TR?= MXvTRW5ITVJ?
DOK NFeySHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7TTWM2OD12LkK2OVk{KM7:TR?= NVvmdHdRW0GQR1XS
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KYSE-70 M2D4c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXK2SWd3UUN3ME20MlI6OzRizszN M2rhNXNCVkeHUh?=
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SCC-25 NG\0XWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTRwM{W4NVkh|ryP MojtV2FPT0WU
EPLC-272H NVPjeGFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3GzbWlEPTB;ND6zPFk2KM7:TR?= NFXuUpNUSU6JRWK=
CAL-120 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTaTWM2OD12LkO4PVkzKM7:TR?= NXvqe5RkW0GQR1XS
LS-513 M1rwcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zremlEPTB;ND60NlE6QCEQvF2= MXXTRW5ITVJ?
CAPAN-1 NVnae2lYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTRwNEKzPFIh|ryP MUPTRW5ITVJ?
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CP50-MEL-B NYDmWoVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37vVGlEPTB;OT65NlQ{OiEQvF2= MVHTRW5ITVJ?
SK-MEL-28 M3zYZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjUTWM2OD1zMD6wNVk{KM7:TR?= M3LyfnNCVkeHUh?=
NCI-H2452 NHnib4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\GPWpKSzVyPUGwMlE3KM7:TR?= MmToV2FPT0WU
NCI-H1395 MljDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjPNnBVUUN3ME2xNE4yPzhizszN M2m0OXNCVkeHUh?=
NCI-H2052 M3;nSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTXd3RKSzVyPUGwMlE5QDJizszN NFX6WXRUSU6JRWK=
A375 NGfPO2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTFyLkK0OVIh|ryP MWPTRW5ITVJ?
HCC38 MmPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDD[YRMUUN3ME2xNE4{OjJizszN NW\HbpBvW0GQR1XS
LK-2 MnLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\OVmlEPTB;MUCuOFIxQCEQvF2= MXXTRW5ITVJ?
SF126 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1S5Z2lEPTB;MUCuOFczPyEQvF2= NISySpNUSU6JRWK=
SK-MEL-1 M33JU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTFyLke4N|gh|ryP MUfTRW5ITVJ?
ACN NVjEcpdrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfiXYNkUUN3ME2xNE45Pjd7IN88US=> M1\XSHNCVkeHUh?=
BB30-HNC NX7YemplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jVcmlEPTB;MUCuPFcyOSEQvF2= MoPIV2FPT0WU
NCI-H747 NVnWcXJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1S5b2lEPTB;MUCuPFc1PiEQvF2= NV;keI1MW0GQR1XS
KYSE-150 NIXpW25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHi0V4lKSzVyPUGxMlA{QDdizszN NIC5ZlFUSU6JRWK=
D-247MG MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTFzLkGwNFkh|ryP NHf4dVFUSU6JRWK=
BxPC-3 NIXUNGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{P5c2lEPTB;MUGuN|c1PyEQvF2= NHrS[2VUSU6JRWK=
SK-MEL-30 NHXYcFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjnTXdKSzVyPUGxMlQxPzlizszN MXvTRW5ITVJ?
CAS-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\EcWFKSzVyPUGxMlQyODlizszN M4njRnNCVkeHUh?=
no-10 MojLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTF{LkGyNVch|ryP M2PJZnNCVkeHUh?=
NCI-H2405 M2HzVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rVR2lEPTB;MUKuNlA{PiEQvF2= NVzxUpR7W0GQR1XS
KGN NWnYfFdzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVj2R4xUUUN3ME2xNk4zQTBzIN88US=> M2G1THNCVkeHUh?=
BB49-HNC Mk\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTEbZdKSzVyPUGyMlM6PTZizszN M4L3WnNCVkeHUh?=
NCI-H1693 MmruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDKcIpKSzVyPUGyMlU5OTZizszN M3vocnNCVkeHUh?=
RO82-W-1 NH3afXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonuTWM2OD1zMz6wOlQ6KM7:TR?= MXLTRW5ITVJ?
CAL-85-1 NVfiXmtJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnEeWlGUUN3ME2xN{41Ozl7IN88US=> M{XyU3NCVkeHUh?=
H-EMC-SS M1\wdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvWSJNKSzVyPUGzMlkyODRizszN MV;TRW5ITVJ?
SW1783 NYfYUHM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnuzTWM2OD1zND6yN|kyKM7:TR?= M1HPOXNCVkeHUh?=
LB771-HNC M2DWW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{H5ZmlEPTB;MUSuOFE6KM7:TR?= MYnTRW5ITVJ?
HCC70 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo[1TWM2OD1zND60NlM{KM7:TR?= MWnTRW5ITVJ?
KNS-81-FD MmHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LyOGlEPTB;MUSuO|A1PSEQvF2= NHe2UVJUSU6JRWK=
KYSE-520 NVH5SGJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTF2LkmyO{DPxE1? MkfvV2FPT0WU
TGBC24TKB MknsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTF2Lkm1N|kh|ryP M1nkOnNCVkeHUh?=
SNB75 NVHw[XM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XCfmlEPTB;MUWuNFczQSEQvF2= MV;TRW5ITVJ?
SW872 MmnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTF3LkKyNVgh|ryP MorxV2FPT0WU
U031 MoTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHDSVZKSzVyPUG1MlgxOjhizszN MoHjV2FPT0WU
ChaGo-K-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3LTWM2OD1zNT64N|U6KM7:TR?= M{nBb3NCVkeHUh?=
NCI-H441 Mn7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4roVGlEPTB;MU[uNFA{QSEQvF2= Mkf6V2FPT0WU
TE-12 M1LUbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3pTWM2OD1zNj6xPFc{KM7:TR?= MkLrV2FPT0WU
NCI-H1755 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33mWmlEPTB;MU[uOVc{KM7:TR?= NIn3OXBUSU6JRWK=
KNS-42 M3nv[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3zTWM2OD1zNj62OVg6KM7:TR?= NHPBW4FUSU6JRWK=
SK-PN-DW MmL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTF5LkSyNFEh|ryP NXv4dYRwW0GQR1XS
NCI-H226 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLHeWN1UUN3ME2xO{46OzR3IN88US=> M1TVWHNCVkeHUh?=
K-562 M2fX[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDtPJZGUUN3ME2xPE43OzF5IN88US=> NHvrbnlUSU6JRWK=
A388 NFvBS3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHryNI9KSzVyPUG5MlA{ODNizszN M3v4NHNCVkeHUh?=
ZR-75-30 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mke5TWM2OD1zOT6wPVY5KM7:TR?= M1fv[XNCVkeHUh?=
LU-135 NIfjXZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvnToNKSzVyPUG5MlI3OzZizszN NXj4NXFWW0GQR1XS
NCI-H2029 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlT2TWM2OD1zOT62NFIyKM7:TR?= MYfTRW5ITVJ?
HT-1197 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHvTWM2OD1zOT65NlI4KM7:TR?= M3K1N3NCVkeHUh?=
IGR-1 M4rVdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDtTWM2OD1{MD6zNVE4KM7:TR?= M{HYNHNCVkeHUh?=
U-87-MG MnTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTJyLk[0NVMh|ryP MkW3V2FPT0WU
NCI-H1304 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXsTWM2OD1{MD63OVAyKM7:TR?= MWPTRW5ITVJ?
RCC10RGB NEjjbXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHoTWM2OD1{MT6yPFI6KM7:TR?= M4\RTHNCVkeHUh?=
NCI-H520 M4Hk[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlu4TWM2OD1{Mj63OlEyKM7:TR?= MknFV2FPT0WU
SK-LU-1 Mk\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfHSIxKSzVyPUKzMlA4OThizszN MV;TRW5ITVJ?
UACC-893 MnLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvmTWM2OD1{Mz6xNFM5KM7:TR?= MUfTRW5ITVJ?
NCI-H2347 NV6xboRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fjVWlEPTB;MkOuNlY4PCEQvF2= NHrR[GtUSU6JRWK=
U-118-MG MoDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Ow[WlEPTB;MkOuO|IyPyEQvF2= MkniV2FPT0WU
NCI-H596 NVT4fm43T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTJ|LkmwOVUh|ryP MXzTRW5ITVJ?
MZ1-PC M2TWOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fXR2lEPTB;MkSuOlc2QSEQvF2= MULTRW5ITVJ?
SW1417 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvITWM2OD1{NT6yOFk5KM7:TR?= NWLpO3VXW0GQR1XS
NCI-H82 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTJ4LkSyPFgh|ryP NHvaWJFUSU6JRWK=
COLO-678 NX7JOFVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPMbo44UUN3ME2yO{41QTF7IN88US=> MY\TRW5ITVJ?
KURAMOCHI NXLKUYxRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLyPWJKSzVyPUK4MlEzPiEQvF2= M3;wc3NCVkeHUh?=
NCI-H1650 M1LuNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXtUY5{UUN3ME2zNE4yQTJ2IN88US=> NHyxWmxUSU6JRWK=
HCC1954 NGHCTHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkW4TWM2OD1|MT6zOlY3KM7:TR?= MYTTRW5ITVJ?
GAK MonUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Dq[GlEPTB;M{KuNlYyPiEQvF2= M13Zb3NCVkeHUh?=
YAPC MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jCe2lEPTB;M{OuO|Y1QCEQvF2= M2PneXNCVkeHUh?=
NCI-H2228 NWXSWYJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYn5cGtGUUN3ME2zOE4{PjB3IN88US=> MkDxV2FPT0WU
VMRC-RCZ Mn3YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\tcpM2UUN3ME2zOk4{ODJ{IN88US=> MoXYV2FPT0WU
NMC-G1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7hUmJKSzVyPUO3MlA2OjlizszN NHm5UlhUSU6JRWK=
D-336MG MkfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzkb4llUUN3ME20NU45PDR{IN88US=> MVrTRW5ITVJ?
UACC-62 Mk\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\0eWlEPTB;NEKuOVUxPSEQvF2= MnfYV2FPT0WU
C-33-A M1P1bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfhfnVKSzVyPUS1MlMzPTZizszN NILhXZdUSU6JRWK=
HCC1937 NGqxdYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTR5LkG5OVgh|ryP M1HSZXNCVkeHUh?=
HDLM-2 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIW0RWZKSzVyPUS3MlIzQDdizszN MX;TRW5ITVJ?
NCI-H727 NF24ZXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zNWGlEPTB;NEeuNlQ2OSEQvF2= NX3jVpI{W0GQR1XS
NY M1PPdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTR7LkO5NFgh|ryP M1LNbHNCVkeHUh?=
NCI-H2291 NITNenBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHz2fW1KSzVyPUS5Mlg{ODFizszN M2P2TnNCVkeHUh?=

多くの細胞株試験データを見る場合、クリックしてください

体内試験 Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

お薦めの試験操作(参考用のみ)

キナーゼ試験:

[1]

+ 展開

Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
細胞試験:

[2]

+ 展開
  • 細胞株: LNCaP, PC-3, and TSU-Pr1
  • 濃度: Dissolved in DMSO, final concentrations ~7.5 μM
  • 反応時間: 1, 2, 3 and 4 days
  • 実験の流れ:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (参考用のみ)
動物試験:

[2]

+ 展開
  • 動物モデル: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • 製剤: Dissolved in DMSO
  • 投薬量: ~100 mg/kg/day
  • 投与方法: Injection i.p.
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
混合させたのち直ちに使用することを推奨します。
5mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 264.3
化学式

C14H20N2O3

CAS No. 149647-78-9
保管
in solvent
別名 SAHA, MK0683, suberoylanilide hydroxamic acid

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01059552 Active, not recruiting Locally Advanced Non-small Cell Lung Cancer Fox Chase Cancer Center|National Comprehensive Cancer Network December 6, 2009 Phase 1
NCT02108002 Enrolling by invitation Von Hippel-Lindau Disease National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) March 5, 2014 Phase 1
NCT03022565 Not yet recruiting Uveal Melanoma Nicolas Acquavella|University of Miami Sylvester Comprehensive Cancer Center|University of Miami April 2017 --
NCT02943642 Not yet recruiting Mycosis Fungoides Angimmune LLC|City of Hope National Medical Center|Columbia University|Dana-Farber Cancer Institute|Feinberg School of Medicine, Northwestern University|H. Lee Moffitt Cancer Center and Research Institute|Ohio State University Comprehensive Cancer Center|Rush University Medical Center|Scott and White Hospital & Clinic|Yale University|Stanford University|Thomas Jefferson University|University of Arkansas|University of Colorado Denver School of Medicine Barbara Davis Center|University of Texas Southwestern Medical Center|University of Washington|Vanderbilt University School of Medicine|Washington University School of Medicine January 2017 Phase 2
NCT02836548 Recruiting Melanoma|Skin Neoplasms The Netherlands Cancer Institute June 2016 Phase 1|Phase 2
NCT02589145 Recruiting Lymphoma M.D. Anderson Cancer Center|Celgene Corporation June 2016 Phase 1|Phase 2

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

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Tags: Vorinostat (SAHA, MK0683)を買う | Vorinostat (SAHA, MK0683) ic50 | Vorinostat (SAHA, MK0683)供給者 | Vorinostat (SAHA, MK0683)を購入する | Vorinostat (SAHA, MK0683)費用 | Vorinostat (SAHA, MK0683)生産者 | オーダーVorinostat (SAHA, MK0683) | Vorinostat (SAHA, MK0683)化学構造 | Vorinostat (SAHA, MK0683)分子量 | Vorinostat (SAHA, MK0683)代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID