Vorinostat (SAHA, MK0683)

製品コードS1047 別名:SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683)化学構造

分子量(MW):264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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JPY 24402.00
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文献中の使用例(100)

カスタマーフィードバック(20)

  • Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

    D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

製品安全説明書

HDAC阻害剤の選択性比較

生物活性

製品説明 Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
ターゲット
HDAC [1]
(Cell-free assay)
~10 nM
体外試験

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 M3Lt[2tqdmG|ZTDBd5NigQ>? MVexJIg> NVv5fm1zTE2VTx?= MUXhcpRqNUiGQVOxJIFkfGm4aYT5JJdqfGhiSVO1NEBw\iByLkGxNkDPxE1? NHXDNlUyOTl4MES4PS=>
Friend leukemic cell Mni0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HrVFUxKM7:TR?= MWq3NkBp M2XWNmROW09? NIW5WVFKSzVyPUCuPVkh|ryP Ml7PNVIyODl7MUO=
K562 Mk\jT4lv[XOnIFHzd4F6 M4\CZVYhcA>? MXzEUXNQ M4CzT2lvcGmkaYTpc44hd2ZiaIXtZY4hcGm|dH;u[UBl\WGlZYT5cIF{\SBqbXn4eJVz\SCxZjDISGFEOSCjbnSgTGRCSzJrIIfpeIghUUN3MDDv[kAxNjBzIN88US=> NYrlfJpYOTJ2MUmzPFA>
HT1080 MmjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGf0TG04OiCq MUnEUXNQ MnLDTWM2OD1{LkSg{txO MoTPNVIzPzBzN{W=
H1299 MWLLbY5ie2ViQYPzZZk> NWrEXmYyOjBibXnu M33pSmROW09? NHX1XXBKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhUESDQzDlcpp6dWVid3n0bEBKSzVyIH;mJFAvOTl2IN88US=> NX7GZXgxOTR3MkG0NlI>
H1299 NEfvbIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGWyfXM4OiCq M1LxVWROW09? NV3YVJZZUUN3ME23MlI1KM7:TR?= M{X5fFE1PTJzNEKy
HeLa MUDLbY5ie2ViQYPzZZk> NHPyXoU{OCCvaX6= NVza[llSUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgbIl{fG:wZTDk[YFk\XS7bHHz[UB4cXSqIFnDOVAhd2ZiMD6yPEDPxE1? M2XzSFE2PjB|OUS5
LOX-IMVI NYG0Spc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU[0PEBp NUL4cY5tUUN3ME2xMlMh|ryP M3rE[|E2PzF3NEew
NCI-H226 NEnoSpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXW0PEBp MlO1TWM2OD1{Lk[g{txO MV2xOVcyPTR5MB?=
RXF-631L Mn3nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV[0PEBp NFzNeFJKSzVyPUKg{txO NWm5XWc3OTV5MUW0O|A>
SNB-78 MmrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDVR|ZqPDhiaB?= NVn1NY9DUUN3ME2xOkDPxE1? MXexOVcyPTR5MB?=
St-4 MoDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHSzSVA1QCCq NGn3V3dKSzVyPUWuNkDPxE1? MUexOVcyPTR5MB?=
ARP1 MVLGeY5kfGmxbjDBd5NigQ>? NFLBOY0zKM7:TR?= NGHJZ3c3KGh? M2jZU2lv\HWldHnvckBw\iCSMkHXRWYyKGenbnWg[ZhxemW|c3nvci=> M3jYe|E1PzN2OEC2
CEM MlvRT4lv[XOnIFHzd4F6 MlT1NUBp NYPhU4s6TE2VTx?= NYTTWnI2UW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlM{KM7:TR?= MVSxOlQzODB4NB?=
HCT15 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7GZpk1QCCq MorjS2k2OD1yLkiyJO69VQ>? MX6xOlczOzJ{Nx?=
NCI-H23 M2rkN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrVOFghcA>? M2exdWdKPTB;MD65NkDPxE1? NXTkcndvOTZ5MkOyNlc>
GM15850 MkXTT4lv[XOnIFHzd4F6 MYGyMlUh|ryP NYLuR|RKQTZiaB?= NISzbHhFVVOR MkHVTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSEOgcJl{cW6nIEG0JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n NH7WZWkyPjl{MUO2Oy=>
GM15850 NIfZeHJMcW6jc3WgRZN{[Xl? NVPhbI1QOi53IN88US=> MXG5OkBp M3HjR2ROW09? NEi4NZlKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgOUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= M4HPbFE3QTJzM{[3
GM15850 MlGxT4lv[XOnIFHzd4F6 NWjoRVcyOi53IN88US=> NWTDfWZQQTZiaB?= NWjTbZBiTE2VTx?= NFvRTlZKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgNVIh[WOndInsZZRqd25ib3[gSnhPKGenbnW= MYexOlkzOTN4Nx?=
GM15850 NVS5emRsU2mwYYPlJGF{e2G7 MkXrNk42KM7:TR?= NFK0T5k6PiCq NFPlbW9FVVOR NF\p[VRKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgPUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NIi4W4EyPjl{MUO2Oy=>
GM15850 NGP5[IpMcW6jc3WgRZN{[Xl? M3fNVlIvPSEQvF2= NHXvR4k6PiCq M{nBSGROW09? NWnme2lTUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFgh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NHT1cXoyPjl{MUO2Oy=>
GM15850 M2XmZWtqdmG|ZTDBd5NigQ>? NFLidlkzNjVizszN NXHCe4p7QTZiaB?= NGL6OoRFVVOR MkTZTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEG2JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n NGLjVVAyPjl{MUO2Oy=>
U937 M136OmZ2dmO2aX;uJGF{e2G7 MVq1JO69VQ>? M3jIOlI1KGh? M2C2c2ROW09? MkTkR4VtdCCleXPs[UBienKnc4SgZpkh[WOldX31cIF1cW:wIHH0JHMwTzJxTTDwbIF{\Q>? NHSwRpUyPzByNEexPC=>
H661 NF\Wc3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYG0PEBp NFPoWodKSzVyPUGg{txO MWixO|E2PzByOR?=
U937 MX7GeY5kfGmxbjDBd5NigQ>? MlTqOUDPxE1? M3;2VVI1KGh? M1K4eGROW09? NH\5[FFKdmO{ZXHz[UBqdiCqaYP0c45mKEh|IHHj[ZR6dGG2aX;u NYnJOndjOTd2NEe3OVA>
U937 MWfGeY5kfGmxbjDBd5NigQ>? M2H1[|Eh|ryP MXGyOEBp M{TKTGROW09? M13PeWVn\mWldDDvckBidHCqYTD0eYJ2dGmwIHHj[ZR6dGG2aX;u MkT1NVc1PDd5NUC=
RAW264.7 M3ixbGZ2dmO2aX;uJGF{e2G7 Mn3jNVAh|ryP MUeyOIg> NXfGSXZEf2G2ZYK= NXfpfVcxUW6qaXLpeIlwdiCxZjDMVHMue3SrbYXsZZRm\CCWTl\hcJBp[SCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAxNjd4IN88US=> MlHSNVc1Pzd3MUi=
RAW264.7 M4fnN2Z2dmO2aX;uJGF{e2G7 Mn:4NVAh|ryP MW[yOIg> NV\ZNlNDf2G2ZYK= NHzE[Y1KdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKE6RIIDyc4R2[3Srb36ge4l1cCCLQ{WwJI9nKDFwOEig{txO NUPiW5E5OTd2N{e1NVg>
SC9 NY\3WWFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXnWI01QCCq Mn21TWM2OD1yLk[wOkDPxE1? M2T4Z|E4PTB5MkG5
ST14A NH21NmxHfW6ldHnvckBCe3OjeR?= MnfJOUBvVQ>? M1rWTFczKGh? NYDUdmd7UW6lcnXhd4UhcW5iUlXTWE9PWlOIIH3SUmEh\XiycnXzd4lwdg>? MXWxO|U3PTl7Mx?=
ST14A M3zaO2Z2dmO2aX;uJGF{e2G7 MnjjOUBvVQ>? MkXLO|IhcA>? Ml3JTY5kemWjc3WgbY4hTTKIMTDtVm5CKGW6cILld5Nqd25? MW[xO|U3PTl7Mx?=
PANC1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHi4WlYyKM7:TR?= MorZTWM2OD1yLkS1JO69VQ>? NYO5O5NSOTd3OEi3OFQ>
PANC1 NGXTUnFHfW6ldHnvckBCe3OjeR?= NWLWcINCOSEQvF2= MnTnNlQhcA>? NIXET5FKdmO{ZXHz[UBqdiCyMkHXRWYyN0OLUEGg[4Vv\SCneIDy[ZN{cW:w NWTZNIM3OTd3OEi3OFQ>
PANC1 NXnOTWpiTnWwY4Tpc44hSXO|YYm= NFOwTJAyKM7:TR?= NX\5VYJxOjRiaB?= M2H5T2lv[3KnYYPlJIlvKHB{N3vpdFEh\2WwZTDlfJBz\XO|aX;u NFyzUm4yPzV6OEe0OC=>
PT45 NUXyRYdrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk[wTWM2OD12IN88US=> NVXzNYNoOTd3OEi3OFQ>
ACHN M2Dyb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3m2ZVIyKGh? NFTIVVNIUTVyPUCuOlUh|ryP NFiyXFAyPzZ4Mk[wOi=>
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DMS114 NFHUOZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;LR|Q5KGh? MoPVS2k2OD1{Lkmg{txO MYexPVQyQTJyNR?=
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Primary bronchial epithelial cell M{\CZmtqdmG|ZTDBd5NigQ>? MW[xJO69VQ>? NHTR[I4zPCCq MmLISG1UVw>? M4DNVWlvcGmkaYTpc44hd2ZiSFTBR|ch[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJI12fGGwdDDG[IVtfGF3MEigR2ZVWiCycn;0[YlvKGGyaXPhcEB{fXKoYXPlJIxw[2GuaYrheIlwdg>? M{joOVE6QTZ4N{i5
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SCC25 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWO3NkBp M4nxcmlEPTB;MT65N{DPxE1? MWeyNFE1Ozd5OB?=
SKHEP1 M1;Zdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX:3NkBp MkOzTWM2OD1|LkS2JO69VQ>? M{D4TlIxOTR|N{e4
BJ NIW0VYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXrRXpQOTByIN88US=> M4nxWlQ5KGh? MYjEUXNQ MXnHdo94fGhiaX7obYJqfGmxbjDheEAxNjB3IITvJFExOCC3TR?= NWXJRW9TOjBzNEO4OFA>
MUF M{PubWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWmxNFAh|ryP M33hTVQ5KGh? NVTxV|RSTE2VTx?= MUXHdo94fGhiaX7obYJqfGmxbjDheEAxNjB3IITvJFExOCC3TR?= M{PJOVIxOTR|OESw
Caco-2 NVrNbpVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLUUIRzOTByIN88US=> NWPMNHE6PDiq Mo\ZSG1UVw>? M4D4eWlEPTB;OD6xJO69VQ>? NU\NeXptOjBzNEO4OFA>
Caco-2 M3;o[mtqdmG|ZTDBd5NigQ>? NUHLW3NbPSEQvF2= M2DzZlQhcA>? NHjOOGtFVVOR MVHJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHHj[ZR6dGG2aX;uJGlEPTBib3[gNE4xOzdizszN NUj4eIl2OjBzNEO4OFA>
Caco-2 NG\xTJJMcW6jc3WgRZN{[Xl? MX6wMlMyPiCwTTD0c{A{OS54IN88US=> NETMdWE1KGh? MlfPSG1UVw>? MmjFSZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUNzIIfpeIghUUN3MDDv[kAxNjFzOTFOwG0> NYTLOotMOjBzNEO4OFA>
Caco-2 M1TnZmtqdmG|ZTDBd5NigQ>? NEWwUXcxNjNzNjDuUUB1dyB|MT62JO69VQ>? MmDnOEBp M4HLTmROW09? M1zwO2V5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFMzD3bZRpKEmFNUCgc4YhOC5zNEeg{txO NX;SXmRKOjBzNEO4OFA>
Caco-2 M1\YNWtqdmG|ZTDBd5NigQ>? MnG5Ok4{OiCwTTD0c{A3OzJizszN NYfjXY04PCCq MmexSG1UVw>? NWfmXIRoTXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVO1JJdqfGhiSVO1NEBw\iBzMj62JO69VQ>? NVvlS2h{OjBzNEO4OFA>
Caco-2 MWLLbY5ie2ViQYPzZZk> NXvBVmUyPi5|MjDuUUB1dyB4M{Kg{txO M{HtSlQhcA>? NIWxSXVFVVOR MmX6SZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN5IIfpeIghUUN3MDDv[kA1OSEQvF2= MkTNNlAyPDN6NEC=
Caco-2 MoPuT4lv[XOnIFHzd4F6 NGH3Z3kxNjNzNjDuUUB1dyB|MT62JO69VQ>? MX60JIg> MWHEUXNQ NIL4dotGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{[= NV7uVmFWOjBzNEO4OFA>
HepG2 NVPhNnF4U2mwYYPlJGF{e2G7 NWXMWJRIPSEQvF2= NV3CUlkyPmh? NWTvPXRoTE2VTx?= MnvLTY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgbIl{fG:wZTDhZ4V1gWyjdHnvci=> M1;Qe|IxOTR|OESw
HepG2 M2HuPWtqdmG|ZTDBd5NigQ>? MXu1JO69VQ>? Ml3FOog> NFH3cYNFVVOR NWradoNGUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhcGm|dH;u[UBpgXCncnHj[ZR6dGG2aX;u MoPLNlAyPDN6NEC=
HepG2 M{fBfGtqdmG|ZTDBd5NigQ>? MWm1JO69VQ>? MlHJOog> MXTEUXNQ NF;XSJRKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBidHCqYT30eYJ2dGmwIHHj[ZR6dGG2aX;u NITzPJQzODF2M{i0NC=>
HepG2 NGnZVmVMcW6jc3WgRZN{[Xl? MofHOUDPxE1? MUe2bC=> NHK4fZRFVVOR MWTJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDIN{9JPCCqaYP0c45mKGGlZYT5cIF1cW:w MlP1NlAyPDN6NEC=
COLO205 NU\WRlNnU2mwYYPlJGF{e2G7 MVuxNEDPxE1? M2DrcVI1KGh? MnfxSG1UVw>? NVfBNIVNUW6qaXLpeIlwdiCxZjDISGFEOSCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhcGm|dH;u[UBJOyCjY3X0fYxifGmxbjD3bZRpKEmFNUCgc4YhOi5{IN88US=> NVzXPIZoOjB2NUGzO|g>
SCC4 MX\LbY5ie2ViQYPzZZk> MnX3NUDPxE1? NHX3[VUzPGh? M1zzV2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjD0eYJ2dGmwIHHj[ZR6dGG2aX;u MWSyNFQ2OjJ{NR?=
SCC4 NH7wOJNMcW6jc3WgRZN{[Xl? NWTQPGsyOSEQvF2= NEDuWo0zPGh? NH;4S4dKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDhZ4V1gWyjdHnvci=> MXSyNFQ2OjJ{NR?=
SCC4 NGTHZ49HfW6ldHnvckBCe3OjeR?= MWKxJO69VQ>? MknWOUBucW5? NGDXOGVC\2:waYP0JIFkfGm4aYT5JIF1KF[GUjDhd5Nme3OnZDDhd{BqdmS3Y4Tpc44hd2ZiQ2nQNlQh\2WwZTDlfJBz\XO|aX;u NXSzW3hbOjB2NUKyNlU>
NB4 MWHGeY5kfGmxbjDBd5NigQ>? NWnuZoJiPSEQvF2= MXmyOEBp NHLyTWNFVVOR M4LEWmNmdGxiY4njcIUh[XK{ZYP0JIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHHjZ5VufWyjdHnvckBifCCycnWtS|EheGijc3W= NGLzS|czODR7MUS0NC=>
NB4 MoC4T4lv[XOnIFHzd4F6 Ml\QOUDPxE1? MnTnNlQhcA>? Moi3SG1UVw>? NEDYTJlKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZYNmfHmuYYTlJJR2[nWuaX6gcIV3\Wx? M1i2fVIxPDlzNESw
NB4 M3uxSGZ2dmO2aX;uJGF{e2G7 NEL3OoY2KM7:TR?= NH;kU5gzPCCq NXPmUFNbTE2VTx?= NU\DWXBXUW6mdXP0bY9vKG:oIICyNXdCTjFxQ1nQNUBmgHC{ZYPzbY9v MXiyNFQ6OTR2MB?=
NB4 MWDLbY5ie2ViQYPzZZk> M1zKPFUh|ryP MUOyOEBp M4HpcGROW09? MXrJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDhZ4V1gWyjdHnvci=> MVWyNFQ6OTR2MB?=
NUGC3 NH3XVmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWX0[G1CT0l3ME2yMlk1KM7:TR?= NEHme2YzODh3MEm3NS=>
A549 Mlu3SpVv[3Srb36gRZN{[Xl? MVe1JO69VQ>? M2XB[lMhcA>? MYPEUXNQ NWPVT5FGUW6mdXP0bY9vKG:oIHH1eI9xcGGpeTDpckBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIFzDN2lK NFrPPIEzODh3NUKwPC=>
HUT78 M3PJdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHO0dXA4OiCq NY\SUlI6TE2VTx?= NWi5O|VTT0l3ME2wMlMh|ryP NEX0VpczODh6NEKwPC=>
U937 NWPDdYZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrCbWs5PzJiaB?= NFLVNHhFVVOR M3jBdmdKPTB;MD6zPUDPxE1? MUeyNFg5PDJyOB?=
A431 MV7DfZRwfG:6aXOgRZN{[Xl? MV63NkBp MlTiR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVQ{OSClZXzsd{BwfmW{ZYjwdoV{e2mwZzDFS2ZTKHerdHigTWM2OCCxZjC0MlIh|ryP MoDtNlExQDB4Mkm=
A549 MkfTR5l1d3SxeHnjJGF{e2G7 NHzYcHQ4OiCq MlLkR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISGFEKHerdHigTWM2OCCxZjCxMlgh|ryP M4K0[lIyODhyNkK5
CAL27 MVLDfZRwfG:6aXOgRZN{[Xl? NHjQTFI4OiCq NVPRSFV{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS0GOMkegZ4VtdHNib4\ldoV5eHKnc4PpcochTUeIUjD3bZRpKEmFNUCgc4YhOy5{IN88US=> MXKyNVA5ODZ{OR?=
HeLa NHWzWm9EgXSxdH;4bYMhSXO|YYm= NWjaSId2PzJiaB?= MXvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJI93\XKneIDy[ZN{cW6pIFjERWMhf2m2aDDJR|UxKG:oIEGuOUDPxE1? NX\LeW1zOjFyOEC2Nlk>
Sf21 M1XqOmtqdmG|ZTDBd5NigQ>? NWnDO4lCOyCq NEXyVHJKdmirYnn0bY9vKG:oIF\sZYchfGGpZ3XkJIh2dWGwIILlZ49u[mmwYX70JGhFSUN6IHX4dJJme3OnZDD3bZRpKEmFNUCgc4YhOS5{IN88US=> NXvETJVzOjFyOEC2Nlk>
SKBR3 NVfmbm1yS3m2b4TvfIlkKEG|c3H5 NHnwfI04OiCq MlTER5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tDWjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiC5aYToJGlEPTBib3[gNk43KM7:TR?= NF\LN|MzOTB6ME[yPS=>
SKOV3 MXzDfZRwfG:6aXOgRZN{[Xl? NHjMeYM4OiCq NEHMcGxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0:YMzDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTVJ{IIfpeIghUUN3MDDv[kAzNjJizszN MU[yNVA5ODZ{OR?=
COR-L23 NFvOSohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jlb|ExKM7:TR?= MlO5O|IhcA>? MnXGSG1UVw>? Mmn0S2k2OD1zLkGg{txO MX[yNVA5ODZ2Nx?=
DU145 M2m1V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXuxNEDPxE1? MYK3NkBp M1v4R2ROW09? MYnHTVUxRTFwMEWg{txO MkDnNlExQDB4NEe=
LoVo MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnIS2xiOTBizszN Mnz0O|IhcA>? MVzEUXNQ M3TlXWdKPTB;MT63JO69VQ>? M4HENlIyODhyNkS3
MCR5-SV2 MnPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLtWIw1OTBizszN MoHuO|IhcA>? NVW0UWprTE2VTx?= NXjwRWZ2T0l3ME2yMlEh|ryP Mmi4NlExQDB4NEe=
HCT116 NUWxWFdtU2mwYYPlJGF{e2G7 M4PQRVMxKM7:TR?= NVHwWo9xOzBiaB?= M2LmNGROW09? M{TocmlvcGmkaYTpc44hd2ZiSFTBR|Yh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIFteGijLYT1ZpVtcW5iYXPleJlt[XSrb36= MXyyNVA5ODZ2Nx?=
HCT116 NULmcGFiU2mwYYPlJGF{e2G7 NUPDbpM2OzBizszN MYCzNEBp MoK4SG1UVw>? MWPJcohq[mm2aX;uJI9nKEiGQVOxJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDobZN1d26nIFizT|kh[WOndInsZZRqd25? MXKyNVA5ODZ2Nx?=
U937 NGDMTndMcW6jc3WgRZN{[Xl? NWD6PHIzPSEQvF2= NILN[WIzPCCq NWnCXlBGTE2VTx?= M{XHOWlvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBi[2W2eXzheIlwdiCxZjDobZN1d26nIFizJIF1KEt7 M3XSTlIyOjl{NEmy
U937 NVrneJlQU2mwYYPlJGF{e2G7 Mo\wOUDPxE1? NGLPbGszPCCq NX;zN4FMTE2VTx?= MoLETY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJIFk\XS7bHH0bY9vKG:oIHjpd5RwdmViSEOgZZQhUzF6 MV2yNVI6OjR7Mh?=
U937 MU\LbY5ie2ViQYPzZZk> MYC1JO69VQ>? NWnsdXhGOjRiaB?= MUfEUXNQ NHPSdphKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4YheGGwLXHj[ZR6dGG2ZXSgbIl{fG:wZTDIOEBt\X[nbB?= NGjTd24zOTJ7MkS5Ni=>
U937 NHvvW5NMcW6jc3WgRZN{[Xl? NFnPfmU2KM7:TR?= NHztWlAyPSCvaX6= M4TNb2ROW09? MWHJcohq[mm2aX;uJI9nKGirc4TvcoUh[WOndInseJJidnOoZYLhd4Uh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[gbIl{fG:wZTDIN{Bi[2W2eXzheIlwdiCuZY\lcC=> MVKyNVI6OjR7Mh?=
A2780 NFnXRldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWO5OkBp M{Tjc2ROW09? NYXO[WJqUUN3ME2xMlYzKM7:TR?= MnTmNlE3OzR2M{C=
COLO205 M3mxWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojSPVYhcA>? MonnSG1UVw>? Mk\QTWM2OD1{LkGyJO69VQ>? Mn3WNlE3OzR2M{C=
Hep3B M33Yc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmGyOFghcA>? NX;VNpF3TE2VTx?= MWjHTVUxRTFwMkGg{txO NV;tU3FlOjF5MUKxOFY>
GM11272 MWPGeY5kfGmxbjDBd5NigQ>? MnLsNVAxKG6P MmjLO|IhcA>? MVnEUXNQ Mm\nVoVi[3SrdnH0bY9vKG:oIF3lR5AzKG23dHHueEBmgHC{ZYPzbY9vKGG2IEGwJJRwKDFyMDDuUS=> NWPKUHNJOjF6NEC3NVY>
CFBE41o NV7F[FU6U2mwYYPlJGF{e2G7 NYXKcHdLPSEQvF2= NGq3TXJFVVOR NVfuXGVVTG:5bjDy[Yd2dGG2aX;uJI9nKEiGQVO3JIF1KDBwMjD0c{A2KHWP NIHUO2EzOTl6NEm1PC=>
CFBE41o MnTFSpVv[3Srb36gRZN{[Xl? MX6xJO69VQ>? NYTLb2g5OjRiaB?= NIfVfYJFVVOR MV;S[ZN1d3KjdHnvckBw\iCFRmTSJIRmdHSjRkWwPEBufXSjboSgeJJi\m[rY3vpcochfG9iY3XscEB{fXKoYXPlJIF{KGeueXPv[o9zdXN? NVHET5ZqOjF7OES5OVg>
DU145 MkDOT4lv[XOnIFHzd4F6 MlTCNk42KM7:TR?= NEnZPVkzPCCq NWTQSXBITE2VTx?= NXS0WnJCUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IIXwdoVofWyjdHnvckBw\iCyMkH3ZYYyKHC{b4TlbY4h\XiycnXzd4lwdg>? M3nyVVIzOjZyMU[2
DU145 MVrLbY5ie2ViQYPzZZk> M1HaN|Uh|ryP MVKyOEBp MYfEUXNQ M3PuR2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCqaYP0c45mKEh2IHHj[ZR6dGG2aX;u NVLXb5JOOjJ{NkCxOlY>
DU145 MWrLbY5ie2ViQYPzZZk> MYm1JO69VQ>? NFHI[5ozPCCq NUn6cFFnTE2VTx?= M4PSVGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCqaYP0c45mKEh|IHj5dIVz[WOndInsZZRqd25? MmnZNlIzPjBzNk[=
786-0 NI\G[pNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmWwOk4zKM7:TR?= M4TrTVczKGh? M{jqPWROW09? M3qxPWdKPTB;Mz6yJO69VQ>? MXKyNlQ{PTZ4OR?=
A498 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLLV4Y3NjJizszN MV:3NkBp MoLVSG1UVw>? M4Ox[WdKPTB;MT62JO69VQ>? M2\5dlIzPDN3Nk[5
A549/ATCC NFnPUIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWO2MlIh|ryP MkixO|IhcA>? MlnESG1UVw>? MoHNS2k2OD1zLk[g{txO MkPaNlI1OzV4Nkm=
ACHN NVWwbZZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV62MlIh|ryP M3\4V|czKGh? NU\obWFGTE2VTx?= M{DPb2dKPTB;MT6zJO69VQ>? Mmn1NlI1OzV4Nkm=
BT549 Mli0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUm2MlIh|ryP M2HpUFczKGh? NX;veVRPTE2VTx?= M1PBdWdKPTB;MT6zJO69VQ>? NUK0[2dJOjJ2M{W2Olk>
EKVX NWf4WXp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvuOk4zKM7:TR?= NWXTT|hvPzJiaB?= MmTLSG1UVw>? MlPjS2k2OD1zLkOg{txO NUjpW|FUOjJ2M{W2Olk>
HCT15 NH[3[XVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ni[FYvOiEQvF2= NEi5UZQ4OiCq Ml7NSG1UVw>? NYj3ZoUyT0l3ME2yMlUh|ryP NUTofI94OjJ2M{W2Olk>
HOP92 MkfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUn4bnVGPi5{IN88US=> NFXPSms4OiCq M3XMSmROW09? MVXHTVUxRTRizszN NXe2N2N{OjJ2M{W2Olk>
IGROV1 Mlz3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITnSYM3NjJizszN NXzVNFJ2PzJiaB?= Ml;0SG1UVw>? MXPHTVUxRTFwMzFOwG0> NX73RYtmOjJ2M{W2Olk>
LOXIMVI NV3QdmJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTaOk4zKM7:TR?= MoTGO|IhcA>? MlO4SG1UVw>? MVTHTVUxRTFizszN NU\2PG41OjJ2M{W2Olk>
M14 MlP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfiOk4zKM7:TR?= NIDZNpM4OiCq NW\HNoxHTE2VTx?= MkO4S2k2OD1zLkOg{txO NFfIdI8zOjR|NU[2PS=>
MALME-3M MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvqN2c3NjJizszN NE\ibHg4OiCq NHfTeJlFVVOR M4KzS2dKPTB;MD6zNkDPxE1? MUSyNlQ{PTZ4OR?=
MCF10A NXXFPWx7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzubWQ3NjJizszN MWG0PEBp Mo\1SG1UVw>? M32wNGdKPTB;OT62JO69VQ>? NXPXTplMOjJ2M{W2Olk>
MDA-MB-435 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUO2MlIh|ryP M3LLZlczKGh? Ml3nSG1UVw>? MmXVS2k2OD1yLkWg{txO NV\5folnOjJ2M{W2Olk>
MDA-MB-468 NGPVR5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2CxVlYvOiEQvF2= NITVVFg4OiCq MlnZSG1UVw>? MX7HTVUxRTBwNkOg{txO MnzMNlI1OzV4Nkm=
MOLT4 NHrMclhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvRRo83NjJizszN MXy3NkBp NHz4W4tFVVOR NEnkTppIUTVyPUCuOEDPxE1? NVXibWtjOjJ2M{W2Olk>
NCI-ADR-RES M4TSSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLROk4zKM7:TR?= NHv5bJI4OiCq MmnESG1UVw>? NYHiO3hXT0l3ME2wMlE3KM7:TR?= M1HKZVIzPDN3Nk[5
NCI-H23 M1rJW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG[5Zo83NjJizszN MYq3NkBp NVLQfZlwTE2VTx?= NIjqOoJIUTVyPUGg{txO MYeyNlQ{PTZ4OR?=
NCI-H322M NF7OWo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjmS3A3NjJizszN M{jjNVczKGh? MoPhSG1UVw>? MUXHTVUxRTBwN{mg{txO M1jWTlIzPDN3Nk[5
NCI-H460 MnLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TDZVYvOiEQvF2= MV[3NkBp M1fjbWROW09? Mn\hS2k2OD1yLke5JO69VQ>? NFP2cIQzOjR|NU[2PS=>
NCI-H522 NHn3[FNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fzSlYvOiEQvF2= MkTHO|IhcA>? MXrEUXNQ MWHHTVUxRTBwNTFOwG0> NHXROJkzOjR|NU[2PS=>
OVCAR3 MoS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDVNnR5Pi5{IN88US=> MUi3NkBp MXnEUXNQ NYXEOoQyT0l3ME2xMlMh|ryP M2rGZ|IzPDN3Nk[5
OVCAR4 M{\GZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rFTVYvOiEQvF2= M{ntS|czKGh? NYDDWXBETE2VTx?= MYTHTVUxRTRizszN NEnqOWszOjR|NU[2PS=>
OVCAR5 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnEc4o6Pi5{IN88US=> NXPs[2hXPzJiaB?= MmPuSG1UVw>? MmTDS2k2OD1yLke5JO69VQ>? MoDXNlI1OzV4Nkm=
OVCAR8 M3TybGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfUOHQ3NjJizszN M3\SR|czKGh? MlfvSG1UVw>? NUi2enNWT0l3ME2wMlUh|ryP M2nOUlIzPDN3Nk[5
RXF393 MnfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVL1T|Q4Pi5{IN88US=> M2[0[lczKGh? MVHEUXNQ NF;GSHhIUTVyPUGuN{DPxE1? MmDENlI1OzV4Nkm=
SF268 NEL0O29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXe2MlIh|ryP MWi3NkBp NXviboQ6TE2VTx?= NHq1TphIUTVyPUGuOkDPxE1? MmX0NlI1OzV4Nkm=
SF295 MmnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XHXVYvOiEQvF2= M4jaVlczKGh? NXTXW2dCTE2VTx?= NFrIRmlIUTVyPUGuOkDPxE1? NEL6XpIzOjR|NU[2PS=>
SF539 M3fVe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWC2MlIh|ryP NHLvZZg4OiCq MnHHSG1UVw>? NWH6VI9lT0l3ME2yJO69VQ>? NXTyfHhlOjJ2M{W2Olk>
SK-MEL-2 MlPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDGOk4zKM7:TR?= M1PMV|czKGh? M{f2TWROW09? MV3HTVUxRTFwMzFOwG0> NHHvcoYzOjR|NU[2PS=>
SK-MEL-28 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXjOk4zKM7:TR?= M4W4d|czKGh? MW\EUXNQ NXfnPIZiT0l3ME2xJO69VQ>? MXKyNlQ{PTZ4OR?=
SK-MEL-5 NYrYd5BmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrEb|A3NjJizszN M33w[FczKGh? Mn3ySG1UVw>? MkDBS2k2OD1yLk[zJO69VQ>? MUiyNlQ{PTZ4OR?=
SKOV3 M4rYdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUm2MlIh|ryP NYGxUZlKPzJiaB?= NU\ydoRYTE2VTx?= MnyxS2k2OD1zIN88US=> M3mzWVIzPDN3Nk[5
SN12C NXXaVVJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVW5fYc3Pi5{IN88US=> MVe3NkBp NFTNcWJFVVOR NX7sV5hST0l3ME2yJO69VQ>? MUCyNlQ{PTZ4OR?=
SNB19 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XZOFYvOiEQvF2= M3zCVFczKGh? NUXaOFJyTE2VTx?= NWfoS3F4T0l3ME2wMlY{KM7:TR?= M3fFPFIzPDN3Nk[5
SNB75 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;FVVYvOiEQvF2= Mor2O|IhcA>? M{jGfmROW09? M2jVXGdKPTB;MD63PUDPxE1? MVOyNlQ{PTZ4OR?=
SR Mo\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXf2ZmhjPi5{IN88US=> NGj3dXk4OiCq MmjRSG1UVw>? M3rrfmdKPTB;MD60JO69VQ>? NVrZUG5uOjJ2M{W2Olk>
T47D MnvCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF63WXQ3NjJizszN MXu3NkBp MUnEUXNQ MoHIS2k2OD1yLkWg{txO MY[yNlQ{PTZ4OR?=
TK10 NV\pVFZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPxbVE3NjJizszN MYq3NkBp M4DuSWROW09? MV;HTVUxRTBwNkOg{txO MmHvNlI1OzV4Nkm=
UACC257 MnztS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojlOk4zKM7:TR?= M{jxUFczKGh? MnPjSG1UVw>? NIqxZ2JIUTVyPUCuOUDPxE1? NGr6TY4zOjR|NU[2PS=>
UACC62 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFH2PZc3NjJizszN MVS3NkBp Ml;0SG1UVw>? MYXHTVUxRTBwNDFOwG0> MnW5NlI1OzV4Nkm=
UO31 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1yxXVYvOiEQvF2= MYi3NkBp NEWzW3ZFVVOR NHXBV2dIUTVyPUCuOUDPxE1? MnWwNlI1OzV4Nkm=
Hep3B NFXjWZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDmfoQ1QCCq MX3EUXNQ NEnwVm9IUTVyPUCuOlkh|ryP M4jhO|IzPDN7OE[z
BE(2)-C NV;yRWJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LlZVczKGh? MXjEUXNQ MYrJR|cxRTJizszN M4PuWVIzQTN{M{G2
Bel7402 NVfzXIJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYW3NkBp MmLISG1UVw>? MX7HTVkxRTF5IN88US=> Mn\KNlMxPjF|N{[=
Bel7404 NEL4N|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfLO|IhcA>? NE\0RnpFVVOR MoSxS2k6OD1zODFOwG0> MXGyN|A3OTN5Nh?=
BGC823 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXlO|IhcA>? NWrVRXExTE2VTx?= Mny2S2k6OD15LkWg{txO NYfGWJNpOjNyNkGzO|Y>
MGC803 Ml:wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nyeFczKGh? NFPXVFdFVVOR NIjmNWVIUTlyPUGwMlgh|ryP NX;1XXI5OjNyNkGzO|Y>
SGC7901 MkDTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PXNVczKGh? NGXsRpZFVVOR MkL4S2k6OD17LkSg{txO MV6yN|A3OTN5Nh?=
SKHEP1 M32yXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\rdG44OiCq NYDQSHhvTE2VTx?= MVXHTVkxRTF5IN88US=> MnjGNlMxPjF|N{[=
SMMC7721 Mlz5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknCO|IhcA>? NWjFWG51TE2VTx?= NFzId|ZIUTlyPUKwJO69VQ>? MX:yN|A3OTN5Nh?=
NUGC3 NIrkdGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUS1d5kxOTBizszN NXnS[HR4T0l;Mj65OEDPxE1? M1HNW|I{OTZ|M{Oy
A2780 CisR NV3nVG9xU2mwYYPlJGF{e2G7 MXOxPEBp NWTHU|FJUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlQ1KM7:TR?= M3H1flI{OjV{NkCz
CAL27 sens NUDFfFFyU2mwYYPlJGF{e2G7 MoixNVghcA>? MmPRTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkO2JO69VQ>? M3y0XlI{OjV{NkCz
CAL27 CisR M{Djd2tqdmG|ZTDBd5NigQ>? NWixVpIzOThiaB?= NULGRmh6UW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?= MXeyN|I2OjZyMx?=
KYSE-510 CisR NH7Qe|RMcW6jc3WgRZN{[Xl? M2PrT|E5KGh? NVTpO5dGUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlU6KM7:TR?= MWeyN|I2OjZyMx?=
KYSE-510 sens MlXGT4lv[XOnIFHzd4F6 MYCxPEBp M2qwXmlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD63JO69VQ>? NGTMbXQzOzJ3Mk[wNy=>
MDA-MB-231 sens NXL1OXZSU2mwYYPlJGF{e2G7 M1Tkc|E5KGh? MWfJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO MnHFNlMzPTJ4MEO=
MDA-MB-231 CisR Mk\zT4lv[XOnIFHzd4F6 NGHNbGYyQCCq NY\kNHhrUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?= NX\IU5pGOjN{NUK2NFM>
ES2 Mnz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{W4O|Q5KGh? MXzEUXNQ NF7lXFdKSzVyPUGyMlch|ryP MmDJNlM1QTN2NEm=
MDA-MB-231 MUjLbY5ie2ViQYPzZZk> MUWxNEDPxE1? MV[zNEBucW5? NVvHS3JzTE2VTx?= MVLJcohq[mm2aX;uJI9nKEiGQVOyZS=> NFTkXXczOzR7M{S0PS=>
MDA-MB-231 NXq2SWFbU2mwYYPlJGF{e2G7 MlXQNUDPxE1? NWjuU5h4OjRiaB?= NV33bos{TE2VTx?= MnjUTY5pcWKrdHnvckBw\iCKRFHDOkBie3Onc4Pl[EBieyCjY3X0fYxifGmxbjDs[ZZmdHNib3[geJVjfWyrbh?= NFLLfXUzOzR7M{S0PS=>
HS68 NHS5bG5EgXSxdH;4bYMhSXO|YYm= NX3JVXhIOTBizszN MmXDO|IhcA>? MnjUSG1UVw>? NUHHdlZzUUN3ME20MlYh|ryP M1XxV|I{PTdyNUSy
MEF MV;DfZRwfG:6aXOgRZN{[Xl? M3jRR|ExKM7:TR?= MWS3NkBp M3\LPWROW09? NUTK[HByUUN3ME20MlQh|ryP NXX1[WdGOjN3N{C1OFI>
BGC823 NGqySG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHywOpZFVVOR NYrXcVBFT0l3ME2zMlA6KM7:TR?= NYPa[VFLOjN4MEG3NFY>
High5 NX7VcYR[U2mwYYPlJGF{e2G7 MoLLNlQhcA>? NUDQcWNjUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEPiC5aYToJGlEPTBib3[gNE4xQSEQvF2= Ml;QNlM3ODJ3MkO=
High5 NVTWVodVU2mwYYPlJGF{e2G7 M2HnXlI1KGh? M3vwSmlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSFTBR|Ehf2m2aDDJR|UxKG:oIECuNVIh|ryP MYWyN|YxOjV{Mx?=
High5 NVTTS4hJU2mwYYPlJGF{e2G7 NWjaUZBsOjRiaB?= MXXJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVOzJJdqfGhiSVO1NEBw\iByLkG3JO69VQ>? MkH4NlM3ODJ3MkO=
A549 M{jrO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\RWmROW09? M3fadGlEPTB;MT6wO|kh|ryP MknjNlM3PDR{MUC=
HCT116 M2i3OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWP5NpE3TE2VTx?= NVPzR3VOUUN3ME2wMlc2PyEQvF2= NFzKWXQzOzZ2NEKxNC=>
K562 NYDGWmdiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHVepJETE2VTx?= MWrJR|UxRTBwNkS1JO69VQ>? MV[yN|Y1PDJzMB?=
GBC-SD NV60e3BCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7GSG42KM7:TR?= M1;nS|czKGh? NWC5OIJxTE2VTx?= Mlf4TWM2OD1zND64JO69VQ>? NWDMXopjOjN5MEeyOlA>
HGC27 Mme3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\yS|Uh|ryP MYO3NkBp M1XxdmROW09? NIXzZZFKSzVyPUWuOEDPxE1? NE\Q[5gzOzdyN{K2NC=>
HL60 MmnhT4lv[XOnIFHzd4F6 MV21JO69VQ>? MWiyOEBp MVzEUXNQ M4niOmlvcGmkaYTpc44hd2ZiSFTBRy=> NGPIVIYzOzdyN{K2NC=>
Vero MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITNZWE4OiCq MULEUXNQ NHzsNGxKSzVyPUCuPUDPxE1? MXiyN|c5PjR3Mh?=
NCI60 NXWwOHR2S3m2b4TvfIlkKEG|c3H5 MonhOFghcA>? NGTQeGZFVVOR M3nOVmdKRTBwNUOg{txO M3XNV|I1ODF3M{K3
SW620 M3HMW2N6fG:2b4jpZ{BCe3OjeR?= MVG0PEBp NX:w[2s{TE2VTx?= Mo\SS2k:OC53NDFOwG0> NEC5dWwzPDBzNUOyOy=>
U251 M1LG[2N6fG:2b4jpZ{BCe3OjeR?= MnXyOFghcA>? MmjhSG1UVw>? NXn5fVJ3T0l;MT61N{DPxE1? NGD5XFEzPDBzNUOyOy=>
KM12 M1HFfWN6fG:2b4jpZ{BCe3OjeR?= MmLyOFghcA>? NVHpfZp5TE2VTx?= Ml\MS2k:OS56ODFOwG0> M4LJWVI1ODF3M{K3
Hs578T MkL3R5l1d3SxeHnjJGF{e2G7 M1fKWlQ5KGh? M3TEXGROW09? NWTCd4VGT0l;ND64N{DPxE1? MXiyOFAyPTN{Nx?=
MDA-MB-231 NHXORZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\uVVNoPDhiaB?= MWHJR|UxRTBwMU[g{txO M1PsTlI1ODl3MEG2
MCF7 NH75WHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fGWFQ5KGh? NXrnV4o5T0l;MD60OUDPxE1? MmXGNlQyOTl3NUW=
MDA-MB-435 M4LFeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLwb5ptPDhiaB?= MorzS2k:OC56ODFOwG0> NIjlUWozPDFzOUW1OS=>
AsPC1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnITploOzBizszN MojIOFghcA>? NVHsfnlbTE2VTx?= Mm\3TWM2OD1|Lk[2JO69VQ>? M17mbFI1OTh3M{e4
Jurkat E6.1 NXjuN|ZjU2mwYYPlJGF{e2G7 MorCNkBp M1nj[mROW09? M3XLVGlvcGmkaYTpc44hd2ZiSFTBR|Qhf2m2aDDJR|UxKG:oIECuNFQh|ryP MXOyOFI3OTh4Mh?=
KG1 Mn3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M364[|Q5KGh? MVzJR|UxRTFwMUWg{txO NGftZoYzPDV{NUCwNy=>
HEL MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrlOFghcA>? NYX5fpJ6TE2VTx?= Mo\jTWM2OD1yLkS5JO69VQ>? M1XpfFI1Pjl2MEW1
HSC3 MXHDfZRwfG:6aXOgRZN{[Xl? Ml3ZNVIhcA>? MWnEUXNQ NEm2fplKSzVyPUCuO|Eh|ryP NY\Hdo5tOjR5Nk[1OlA>
HT-29 M3jCVGN6fG:2b4jpZ{BCe3OjeR?= NH;hfHMyOiCq MYDEUXNQ NWrkNHgyUUN3ME2wMlczKM7:TR?= MnzRNlQ4PjZ3NkC=
KB NUC3V4p4S3m2b4TvfIlkKEG|c3H5 NIi1ZZUyOiCq MVfEUXNQ NFvlWpBKSzVyPUCuO|Uh|ryP NIf0ZVUzPDd4NkW2NC=>
H460 M4S0WGN6fG:2b4jpZ{BCe3OjeR?= NY[2bpJbOTJiaB?= M3vwfmROW09? MY\JR|UxRTBwOEKg{txO NYDsVJJvOjR5Nk[1OlA>
MONE1 MonqR5l1d3SxeHnjJGF{e2G7 MlHiNVIhcA>? NHXSSHdFVVOR M1\hd2lEPTB;MT6xPEDPxE1? MmK5NlQ4PjZ3NkC=
MKN45 NFHpWIFEgXSxdH;4bYMhSXO|YYm= M4W2OlEzKGh? M2PvTGROW09? NEPBUnJKSzVyPUGuNlUh|ryP NV3tZXA2OjR5Nk[1OlA>
TSGH MVfDfZRwfG:6aXOgRZN{[Xl? NV;rWYl1OTJiaB?= MnraSG1UVw>? NFfEcmRKSzVyPUKuNFkh|ryP NGHldlgzPDd4NkW2NC=>
HL60 NEXkNnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTLeVJrPzJiaB?= M2\J[WROW09? NWC0UpFIT0l3ME2wMlk{KM7:TR?= MW[yOFkxODVyMB?=
HEK293 NHP0ZYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3f1RVczKGh? MoLxSG1UVw>? NIfEboVIUTVyPUGzJO69VQ>? NV\HUpM4OjR7MEC1NFA>
Jurkat NVfiN3d1S3m2b4TvfIlkKEG|c3H5 M37DNFExOCEQvF2= MYG3NkBp NXHVNGhkT0l3ME2wMlkh|ryP M2HQ[|I1QTByN{Sz
GM15850 M3XnUWtqdmG|ZTDBd5NigQ>? M37MbFIvPSEQvF2= NV3iT|NIQTZiaB?= MlvCSG1UVw>? MYDkc4V{KG6xdDDpcohq[mm2IFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgNVQh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NYfkeos1OTZ7MkGzOlc>
GM15850 M2nkcWtqdmG|ZTDBd5NigQ>? MkPBNk42KM7:TR?= MY[5OkBp MYLEUXNQ MkX0[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFUh[WOndInsZZRqd25ib3[gSnhPKGenbnW= MnXONVY6OjF|Nke=
GM15850 NXLRUJdLU2mwYYPlJGF{e2G7 MmnSNk42KM7:TR?= NIO5cYw6PiCq MWDEUXNQ M2fqPIRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg1KGy7c3nu[UAyOiCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> MnXNNVY6OjF|Nke=
GM15850 NETOclZMcW6jc3WgRZN{[Xl? NH;nWnczNjVizszN MVe5OkBp NFnHd2FFVVOR Mofa[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFkh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NVvrXWNoOTZ7MkGzOlc>
GM15850 NUXUWIpxU2mwYYPlJGF{e2G7 MnfDNk42KM7:TR?= M1TCblk3KGh? M1HwNGROW09? MU\kc4V{KG6xdDDpcohq[mm2IFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgPEBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MYCxOlkzOTN4Nx?=
GM15850 Ml31T4lv[XOnIFHzd4F6 M3XTTlIvPSEQvF2= MUe5OkBp M3jMVmROW09? NUWwW5oz\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDRibInzbY5mKDF4IHHj[ZR6dGG2aX;uJI9nKE[[TjDn[Y5m MWOxOlkzOTN4Nx?=
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MHH-PREB-1 NGPoRm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTJ7ND61N{BvVQ>? MXLTRW5ITVJ?
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CTB-1 M361XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\0fGhKSzVyPUWzO{46OiCwTR?= M4\LdnNCVkeHUh?=
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NCI-H720 M2fRTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrQfWNXUUN3ME21OlAvOThibl2= MWnTRW5ITVJ?
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DB M2C3RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLkepVKSzVyPUW5PE42PyCwTR?= MnTiV2FPT0WU
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MV-4-11 M3XmWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1H3TGlEPTB;NkW5MlEhdk1? NEf1NXhUSU6JRWK=
RPMI-8226 M376V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPt[WpKSzVyPU[3PE4yQCCwTR?= MXzTRW5ITVJ?
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HEL MofQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRThyNj6wPEBvVQ>? NGrqfHVUSU6JRWK=
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MC-IXC MkTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVO0U|FLUUN3ME2xMlE4QDhzIN88US=> Ml;mV2FPT0WU
LB1047-RCC NIfi[oVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fCNWlEPTB;MT6xPFMyOiEQvF2= NYW4fWMyW0GQR1XS
VM-CUB-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTmTWM2OD1zLkG5NVA5KM7:TR?= NEfPbIhUSU6JRWK=
NB5 NFPoeWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLKUo91UUN3ME2xMlE6QDV4IN88US=> M2SwXHNCVkeHUh?=
SKG-IIIa MnPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonFTWM2OD1zLkKzOFY1KM7:TR?= M1TXN3NCVkeHUh?=
HO-1-N-1 M1jk[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTFwMkO4N|Uh|ryP MULTRW5ITVJ?
EFO-27 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\NTWM2OD1zLkK1NFQ{KM7:TR?= NWXuclN6W0GQR1XS
MHH-NB-11 NYPVVmN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnTTWM2OD1zLkK4N|I6KM7:TR?= MYnTRW5ITVJ?
SW620 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3j0UWlEPTB;MT6yPVAyQCEQvF2= M{XWWXNCVkeHUh?=
MOLT-16 M3;DeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTFwMkm3PVch|ryP NXPMcZlDW0GQR1XS
NTERA-S-cl-D1 NV3GdpM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTFwM{G3OlEh|ryP M2nNOnNCVkeHUh?=
VA-ES-BJ MlPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTVfFc6UUN3ME2xMlMzPDd5IN88US=> MkDtV2FPT0WU
HCC1419 Mo\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDJNI1KSzVyPUGuN|QxOjdizszN NITofJdUSU6JRWK=
NCI-H69 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nmfWlEPTB;MT6zOFEyOiEQvF2= MXTTRW5ITVJ?
DEL NXLBS|VHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHxTWM2OD1zLkO1NVYzKM7:TR?= MlnoV2FPT0WU
LXF-289 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPHTVBKSzVyPUGuN|UzPCEQvF2= Mn\sV2FPT0WU
EW-11 M{TQXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTFwM{[wNlYh|ryP MoflV2FPT0WU
KP-4 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjTTWM2OD1zLkO3NFg2KM7:TR?= Ml3LV2FPT0WU
NOS-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLTNlhKSzVyPUGuOFEyQTRizszN MUXTRW5ITVJ?
SK-NEP-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvzcnBLUUN3ME2xMlQyPjl|IN88US=> Mnj1V2FPT0WU
LAMA-84 M{nZWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fCXmlEPTB;MT60N|k1PSEQvF2= MmPXV2FPT0WU
ES5 NXvFPG9CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HsVmlEPTB;MT60OFMh|ryP NHqzWWRUSU6JRWK=
HuO9 M{jqN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTFwNEWzOlIh|ryP NH;2UW5USU6JRWK=
COLO-684 NGXiWZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnRTWM2OD1zLkS2NVE5KM7:TR?= NWTGV5dvW0GQR1XS
EW-24 M{j6fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3aPVNuUUN3ME2xMlQ3PTNzIN88US=> NUfYXJJlW0GQR1XS
BV-173 M13BZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jPRWlEPTB;MT60O|I6OSEQvF2= MWfTRW5ITVJ?
NCI-H1770 M4nPUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDWTWM2OD1zLkS4OVM3KM7:TR?= NEH3VIdUSU6JRWK=
HuP-T4 M3S1Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfuRmtvUUN3ME2xMlQ6OyEQvF2= MXXTRW5ITVJ?
TYK-nu MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlW1TWM2OD1zLkS5PFUyKM7:TR?= NWrhfW93W0GQR1XS
YH-13 NVjTU4RiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;ZTWM2OD1zLkS5PFk1KM7:TR?= Mm\lV2FPT0WU
H4 NVnOO2ZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHhTWM2OD1zLkWwPVEzKM7:TR?= MYTTRW5ITVJ?
OVCAR-8 MkLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHi5R|FKSzVyPUGuOVQ1PzdizszN NVP2OVhYW0GQR1XS
NCI-H23 Ml[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTFwNUS2OFUh|ryP NUi4boJiW0GQR1XS
ES7 NH7JU5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTFwNUS3O|Mh|ryP NV\0T3RZW0GQR1XS
COR-L88 NInmNXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDadY1KSzVyPUGuOVY1OjRizszN M{DYPHNCVkeHUh?=
TI-73 NVjhZo5iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUm3VXE{UUN3ME2xMlU6ODZizszN Mk\aV2FPT0WU
RT-112 NH\QUZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnIUJB7UUN3ME2xMlU6Ojh2IN88US=> M4\hWnNCVkeHUh?=
HuO-3N1 M{f1WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVO0UYhnUUN3ME2xMlU6Ozh3IN88US=> NVLWTlZVW0GQR1XS
HC-1 NX7jeVM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NID3e5BKSzVyPUGuOVk5PjZizszN NVjJbFVsW0GQR1XS
HT55 NFXBPIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUSzcZVxUUN3ME2xMlY2OTNzIN88US=> M1zlUXNCVkeHUh?=
IA-LM Ml23S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTFwNkmyO|gh|ryP M2PVOnNCVkeHUh?=
EM-2 NIjlPYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HvcWlEPTB;MT63NFAyPCEQvF2= MlrNV2FPT0WU
MHH-ES-1 Mn7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjJWlVKSzVyPUGuO|A1OzVizszN NGq3[WpUSU6JRWK=
CAL-27 M1nIe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTFwN{C2NlEh|ryP M{HYc3NCVkeHUh?=
COLO-800 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PndmlEPTB;MT63NVE4QSEQvF2= NGPZUYxUSU6JRWK=
HCE-T NH7USGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHm1Z|FKSzVyPUGuO|E2KM7:TR?= M3\TfnNCVkeHUh?=
CAMA-1 NVXlTlRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHm2fHBKSzVyPUGuO|E6PzFizszN Moj3V2FPT0WU
LOXIMVI MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzZUGVrUUN3ME2xMlczOTFizszN NGGySlRUSU6JRWK=
NH-12 NXvnNVVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTFwN{K2PVEh|ryP M3Ljb3NCVkeHUh?=
TCCSUP MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTNfpJYUUN3ME2xMlczQDJ7IN88US=> NG\BbJZUSU6JRWK=
MDA-MB-361 NH\5PHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFv1NIhKSzVyPUGuO|MyPTdizszN NUXicYd3W0GQR1XS
EW-16 NHL2VZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTFwN{SxNFch|ryP NUjEfVdIW0GQR1XS
SNU-423 M{PScWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2m3SmlEPTB;MT63OVgzPyEQvF2= NGfGOFdUSU6JRWK=
Daoy MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTFwN{[zNVkh|ryP NHHv[|NUSU6JRWK=
ES4 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;GUXQxUUN3ME2xMlc5PzRzIN88US=> M3PkSnNCVkeHUh?=
PFSK-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTFwOECzO{DPxE1? M2C0O3NCVkeHUh?=
ES3 MlnuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTFwOEK2PFEh|ryP M37xWHNCVkeHUh?=
ONS-76 M4S2SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnXTWM2OD1zLkiyPFk4KM7:TR?= NIPpZ5dUSU6JRWK=
JVM-3 NFjsXIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLWTWM2OD1zLki1OFUyKM7:TR?= NIi3VFFUSU6JRWK=
OS-RC-2 MkTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\TXXRrUUN3ME2xMlg4OTVzIN88US=> MU\TRW5ITVJ?
COLO-320-HSR NH63SYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fMUGlEPTB;MT64PFE6PyEQvF2= MWfTRW5ITVJ?
HN MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4qwdGlEPTB;MT64PFczPSEQvF2= NV;sXnhiW0GQR1XS
HT MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2iyUGlEPTB;MT64PFk1PyEQvF2= Ml3vV2FPT0WU
LoVo NVnqR4FkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\0TWM2OD1zLki5PFEh|ryP NHryZWpUSU6JRWK=
CGTH-W-1 NYrpNWlGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLYTWM2OD1zLki5PVQ3KM7:TR?= NVjq[5U{W0GQR1XS
NB6 Mn6yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nuU2lEPTB;MT65NVI6QCEQvF2= NYS2VWh3W0GQR1XS
EW-22 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjkOWVKSzVyPUGuPVI5QDdizszN M1rMVHNCVkeHUh?=
ES6 NHq2eHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnOTWM2OD1zLkmzOlMyKM7:TR?= M3[3RnNCVkeHUh?=
SCC-15 NUC0dlVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPSTWM2OD1zLkmzPFE6KM7:TR?= MmPpV2FPT0WU
HL-60 M3vRWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3SyVmlEPTB;MT65N|kxOiEQvF2= M4HSdnNCVkeHUh?=
human HOP-92 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTFwOUSwOlUh|ryP MX3TRW5ITVJ?
SW626 MlvXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\HNoZKSzVyPUGuPVQ5QTlizszN MmHsV2FPT0WU
HEC-1 NUe2NWVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\2SXNKSzVyPUGuPVU{PiEQvF2= NXzsT41XW0GQR1XS
LB2241-RCC MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPlTWM2OD1zLkm4NlMyKM7:TR?= NXzBWmJSW0GQR1XS
Ramos-2G6-4C10 NISwSGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHizbYxKSzVyPUGuPVk1QTNizszN M4\pc3NCVkeHUh?=
A101D M1nFdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULBc5VLUUN3ME2yMlIxOzB|IN88US=> MonyV2FPT0WU
NCI-H446 NWHHOlNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\n[XBKSzVyPUKuNFQ2QTlizszN M4jZXXNCVkeHUh?=
SBC-5 NEjPNHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4X1O2lEPTB;Mj6wOlE1PyEQvF2= MVXTRW5ITVJ?
HOS MojGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nyd2lEPTB;Mj6wO|Y2OyEQvF2= M3nXdHNCVkeHUh?=
K5 Ml3JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnHR5hKSzVyPUKuNFc5OTFizszN MmPMV2FPT0WU
HLE MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTJwMEi1Nlkh|ryP MYjTRW5ITVJ?
HSC-2 NXHjU5lJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfQelZKSzVyPUKuNVI5QThizszN NGPhXZZUSU6JRWK=
LCLC-97TM1 NX[zfWw6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVn5UIVsUUN3ME2yMlE1PTh|IN88US=> MXPTRW5ITVJ?
DMS-273 NEjycmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjXNFJPUUN3ME2yMlE1QDN5IN88US=> NWDSRXhFW0GQR1XS
TE-8 M2fpS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHhSXJvUUN3ME2yMlE2PzZ3IN88US=> NFr1bmhUSU6JRWK=
DSH1 NU\vV|RST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTJwMU[zPVgh|ryP M1fjbHNCVkeHUh?=
CAL-51 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nEUWlEPTB;Mj6xOlY6QSEQvF2= NGPm[WZUSU6JRWK=
IST-SL1 M37uXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm[xTWM2OD1{LkG2PFQ1KM7:TR?= MVHTRW5ITVJ?
GCT M3P1Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPQN|VbUUN3ME2yMlE4PzdizszN NGj3WIFUSU6JRWK=
SW948 Mn\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHte5JKSzVyPUKuNVg1PTZizszN MVTTRW5ITVJ?
NOMO-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTJwMUmzNVch|ryP NHLZT21USU6JRWK=
C8166 MmL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTJwMkGzN|Qh|ryP Mn;PV2FPT0WU
OC-314 NGXSendIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTJwMkOyOVkh|ryP M1rvOHNCVkeHUh?=
CAL-39 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\DXIhKSzVyPUKuNlM3OjZizszN MV\TRW5ITVJ?
MDA-MB-453 NULqZYN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnmxTWM2OD1{LkK0Nlc2KM7:TR?= MXvTRW5ITVJ?
A673 MnrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LH[mlEPTB;Mj6yOVg3OiEQvF2= NVX5NYZsW0GQR1XS
HTC-C3 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfGTWM2OD1{LkK2PFUh|ryP MV\TRW5ITVJ?
NCI-H1666 M4\P[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTJwMkixNVEh|ryP NIn1c45USU6JRWK=
PSN1 NH7kc45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XsSGlEPTB;Mj6yPFkyOyEQvF2= M3PvNXNCVkeHUh?=
GI-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTJwM{C1OFMh|ryP NFW4XJpUSU6JRWK=
HuH-7 M3PHXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1L3OGlEPTB;Mj6zNFY{PyEQvF2= NITnO3lUSU6JRWK=
JAR NGe5e5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF:2[49KSzVyPUKuN|E6QDdizszN M2S3S3NCVkeHUh?=
5637 Mni2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTJwM{KxNlkh|ryP MlrQV2FPT0WU
GB-1 NYnwTIttT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;0eVBHUUN3ME2yMlMzOzN3IN88US=> M2HlPXNCVkeHUh?=
KP-N-YS M3LnW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjB[nRKSzVyPUKuN|I3OTVizszN MVXTRW5ITVJ?
OAW-42 M4\nemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDYNJZKSzVyPUKuN|M1OTZizszN NH;v[pNUSU6JRWK=
8-MG-BA NYrTXnBNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zQPWlEPTB;Mj6zN|kxPiEQvF2= NGjZ[FJUSU6JRWK=
RH-18 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTJwM{WwNlIh|ryP NF;jcnJUSU6JRWK=
NCI-H1155 NIG2eodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULxUIRiUUN3ME2yMlM3PzJ3IN88US=> NIjhN5BUSU6JRWK=
NB17 NWO1bYhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTJwM{iyOFMh|ryP NGDkUIxUSU6JRWK=
NCI-H1437 NVnoWog4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjQTWM2OD1{LkSxPFc{KM7:TR?= NYX3SHU1W0GQR1XS
SN12C NHTSVJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mor0TWM2OD1{LkSzNlE1KM7:TR?= MYjTRW5ITVJ?
HSC-3 M2PHVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXyxWW84UUN3ME2yMlQ1PTB7IN88US=> MU\TRW5ITVJ?
GAMG MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTVTJFKSzVyPUKuOFQ2PjFizszN NFPF[WlUSU6JRWK=
HT-1080 NVrFRWtkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPyRZIyUUN3ME2yMlQ1QDZ2IN88US=> M{fvTHNCVkeHUh?=
A549 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTJwNES4PVMh|ryP NXnDeW1MW0GQR1XS
KNS-62 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\EfZZ{UUN3ME2yMlQ2ODZzIN88US=> NXPpe|JzW0GQR1XS
YKG-1 M1LZU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoP4TWM2OD1{LkS1OFM4KM7:TR?= MlfYV2FPT0WU
LU-134-A M1rKTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETDS3ZKSzVyPUKuOFcxODhizszN M{\ySnNCVkeHUh?=
FADU MkLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1ntVWlEPTB;Mj60O|E3OiEQvF2= MUPTRW5ITVJ?
TGBC11TKB MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\YZolKSzVyPUKuOFcyPzdizszN MWPTRW5ITVJ?
HT-3 NFrwTnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\wZWlEPTB;Mj60PVU{PSEQvF2= M3fnXHNCVkeHUh?=
NCI-H2170 NVfW[JNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXmwcHlFUUN3ME2yMlUxPTR7IN88US=> MYXTRW5ITVJ?
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SK-MEL-28 NXTMO4R[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrLOHdWUUN3ME2xNE4xOTl|IN88US=> MnzCV2FPT0WU
NCI-H2452 NF\D[2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrjU3lLUUN3ME2xNE4yPiEQvF2= NHjIPFFUSU6JRWK=
NCI-H1395 M1r0VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFj4SohKSzVyPUGwMlE4QCEQvF2= Ml7OV2FPT0WU
NCI-H2052 MmfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7pTWM2OD1zMD6xPFgzKM7:TR?= NETEPFdUSU6JRWK=
A375 M{f4SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTFyLkK0OVIh|ryP MlnpV2FPT0WU
HCC38 NUnS[IxmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7GTo5KSzVyPUGwMlMzOiEQvF2= NIXWVppUSU6JRWK=
LK-2 NUOzVpQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjGb4lKSzVyPUGwMlQzODhizszN M3TwVnNCVkeHUh?=
SF126 M3\DOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zQT2lEPTB;MUCuOFczPyEQvF2= MlvQV2FPT0WU
SK-MEL-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfnTVNKSzVyPUGwMlc5OzhizszN NVfk[|FoW0GQR1XS
ACN MlLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXzWXQ3UUN3ME2xNE45Pjd7IN88US=> MYDTRW5ITVJ?
BB30-HNC Mn73S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnxOnV{UUN3ME2xNE45PzFzIN88US=> NIDXO|VUSU6JRWK=
NCI-H747 NHvld4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\hVY05UUN3ME2xNE45PzR4IN88US=> MkL3V2FPT0WU
KYSE-150 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\WeVV4UUN3ME2xNU4xOzh5IN88US=> NH23XoNUSU6JRWK=
D-247MG MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\HTWM2OD1zMT6xNFA6KM7:TR?= NHnnUXhUSU6JRWK=
BxPC-3 NFiz[IJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLGTWM2OD1zMT6zO|Q4KM7:TR?= MWDTRW5ITVJ?
SK-MEL-30 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPFT|lKSzVyPUGxMlQxPzlizszN NFzt[GRUSU6JRWK=
CAS-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7lN4xKSzVyPUGxMlQyODlizszN NYnNT4lvW0GQR1XS
no-10 M3jsOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfvT5N1UUN3ME2xNk4yOjF5IN88US=> NVS0XlJ5W0GQR1XS
NCI-H2405 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fodWlEPTB;MUKuNlA{PiEQvF2= MljyV2FPT0WU
KGN MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXTWXlKSzVyPUGyMlI6ODFizszN NHK5fGlUSU6JRWK=
BB49-HNC NFXSSZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTF{LkO5OVYh|ryP NXO4c3pjW0GQR1XS
NCI-H1693 M1vVWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{D5XGlEPTB;MUKuOVgyPiEQvF2= MWHTRW5ITVJ?
RO82-W-1 NFPUfmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTF|LkC2OFkh|ryP MYnTRW5ITVJ?
CAL-85-1 NUfJdIxLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fHSWlEPTB;MUOuOFM6QSEQvF2= MX3TRW5ITVJ?
H-EMC-SS MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrRTWM2OD1zMz65NVA1KM7:TR?= NEjlOmZUSU6JRWK=
SW1783 M{HR[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DDWGlEPTB;MUSuNlM6OSEQvF2= MkXIV2FPT0WU
LB771-HNC M3PsXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLBTWM2OD1zND60NVkh|ryP NUfHNFRiW0GQR1XS
HCC70 NETjZ4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTF2LkSyN|Mh|ryP NHvnV|BUSU6JRWK=
KNS-81-FD NUfoRlRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnqxTWM2OD1zND63NFQ2KM7:TR?= MXvTRW5ITVJ?
KYSE-520 NWLr[GU{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoO4TWM2OD1zND65Nlch|ryP M2Pi[HNCVkeHUh?=
TGBC24TKB NFrne2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTCTWM2OD1zND65OVM6KM7:TR?= MUjTRW5ITVJ?
SNB75 NHHV[5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rnW2lEPTB;MUWuNFczQSEQvF2= M3XteXNCVkeHUh?=
SW872 Mn33S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml[3TWM2OD1zNT6yNlE5KM7:TR?= NGHibnRUSU6JRWK=
U031 Ml\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFn5ZmRKSzVyPUG1MlgxOjhizszN M1HaR3NCVkeHUh?=
ChaGo-K-1 M2DDUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7lTWM2OD1zNT64N|U6KM7:TR?= M1v2ZXNCVkeHUh?=
NCI-H441 NI\lU2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LrbWlEPTB;MU[uNFA{QSEQvF2= NIfCZ5VUSU6JRWK=
TE-12 M1XB[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TVdGlEPTB;MU[uNVg4OyEQvF2= NI\DSWlUSU6JRWK=
NCI-H1755 NFTVS5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXZTWM2OD1zNj61O|Mh|ryP M{K3ZXNCVkeHUh?=
KNS-42 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzhdY1SUUN3ME2xOk43PTh7IN88US=> NYXxWWRlW0GQR1XS
SK-PN-DW MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDLbpZCUUN3ME2xO{41OjBzIN88US=> NITxbGdUSU6JRWK=
NCI-H226 M4TuR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPXTWM2OD1zNz65N|Q2KM7:TR?= MmP1V2FPT0WU
K-562 NHjyWIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\0XI1KSzVyPUG4MlY{OTdizszN MVHTRW5ITVJ?
A388 MnLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTF7LkCzNFMh|ryP Mn3ZV2FPT0WU
ZR-75-30 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXzTWM2OD1zOT6wPVY5KM7:TR?= NFfNOlBUSU6JRWK=
LU-135 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTF7LkK2N|Yh|ryP MnjmV2FPT0WU
NCI-H2029 NVvmVmtmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlm3TWM2OD1zOT62NFIyKM7:TR?= MXXTRW5ITVJ?
HT-1197 NGHQ[YZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HONmlEPTB;MUmuPVIzPyEQvF2= MUDTRW5ITVJ?
IGR-1 NV3EZZBRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13GS2lEPTB;MkCuN|EyPyEQvF2= MX;TRW5ITVJ?
U-87-MG MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFe3OJlKSzVyPUKwMlY1OTNizszN NXnsPIFCW0GQR1XS
NCI-H1304 MoLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rXOGlEPTB;MkCuO|UxOSEQvF2= M3\SUHNCVkeHUh?=
RCC10RGB NEjlc3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojnTWM2OD1{MT6yPFI6KM7:TR?= M{XjUXNCVkeHUh?=
NCI-H520 NIezO4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHBTWM2OD1{Mj63OlEyKM7:TR?= NXXCVFZLW0GQR1XS
SK-LU-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTJ|LkC3NVgh|ryP MXXTRW5ITVJ?
UACC-893 NXfJVGQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXv0ZZhtUUN3ME2yN{4yODN6IN88US=> NGLJdYNUSU6JRWK=
NCI-H2347 NYCxXlFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTpNXVmUUN3ME2yN{4zPjd2IN88US=> M{\JOnNCVkeHUh?=
U-118-MG NWHhenNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV64[Yp2UUN3ME2yN{44OjF5IN88US=> MWDTRW5ITVJ?
NCI-H596 M4\Eemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTJ|LkmwOVUh|ryP MYHTRW5ITVJ?
MZ1-PC M3S5T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTJ2Lk[3OVkh|ryP MkPQV2FPT0WU
SW1417 NUnkRpVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rxcGlEPTB;MkWuNlQ6QCEQvF2= NWXQOZZxW0GQR1XS
NCI-H82 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTJ4LkSyPFgh|ryP Moi4V2FPT0WU
COLO-678 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnSe5pLUUN3ME2yO{41QTF7IN88US=> NIC0UW1USU6JRWK=
KURAMOCHI NI\lUVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTJ6LkGyOkDPxE1? Mlm4V2FPT0WU
NCI-H1650 MorXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fRS2lEPTB;M{CuNVkzPCEQvF2= M3TabXNCVkeHUh?=
HCC1954 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\qbo0{UUN3ME2zNU4{PjZ4IN88US=> MVzTRW5ITVJ?
GAK NGTIXIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrsR2dHUUN3ME2zNk4zPjF4IN88US=> MVHTRW5ITVJ?
YAPC NVTue|J2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4KwcmlEPTB;M{OuO|Y1QCEQvF2= NWTBdGxEW0GQR1XS
NCI-H2228 NGWyPGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmH6TWM2OD1|ND6zOlA2KM7:TR?= NGXL[WZUSU6JRWK=
VMRC-RCZ MlXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHMO|BUUUN3ME2zOk4{ODJ{IN88US=> M2DqRnNCVkeHUh?=
NMC-G1 NXTvbZFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\aTWM2OD1|Nz6wOVI6KM7:TR?= NGjpZpVUSU6JRWK=
D-336MG M4HvOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXCbpJKSzVyPUSxMlg1PDJizszN M4ToeHNCVkeHUh?=
UACC-62 M1jKVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfxTWM2OD12Mj61OVA2KM7:TR?= NYjBSFBtW0GQR1XS
C-33-A NYPoW5ZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTR3LkOyOVYh|ryP MVzTRW5ITVJ?
HCC1937 Ml7lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFSz[GFKSzVyPUS3MlE6PThizszN NXzndlVPW0GQR1XS
HDLM-2 NXvEfoxFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3vSY9KSzVyPUS3MlIzQDdizszN M4HHWnNCVkeHUh?=
NCI-H727 NWHGO5prT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3mzZ2lEPTB;NEeuNlQ2OSEQvF2= NHPWZnlUSU6JRWK=
NY NXnl[4VTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoC3TWM2OD12OT6zPVA5KM7:TR?= NGnVfYZUSU6JRWK=
NCI-H2291 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\nPHJjUUN3ME20PU45OzBzIN88US=> NXm1d2pWW0GQR1XS

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

体内試験 Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

お薦めの試験操作(参考用のみ)

キナーゼ試験:

[1]

+ 展開

Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
細胞試験:

[2]

+ 展開
  • 細胞株: LNCaP, PC-3, and TSU-Pr1
  • 濃度: Dissolved in DMSO, final concentrations ~7.5 μM
  • 反応時間: 1, 2, 3 and 4 days
  • 実験の流れ:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (参考用のみ)
動物試験:

[2]

+ 展開
  • 動物モデル: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • 製剤: Dissolved in DMSO
  • 投薬量: ~100 mg/kg/day
  • 投与方法: Injection i.p.
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
混合させたのち直ちに使用することを推奨します。
5mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 264.3
化学式

C14H20N2O3

CAS No. 149647-78-9
保管
in solvent
別名 SAHA, MK0683, suberoylanilide hydroxamic acid

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01059552 Active, not recruiting Locally Advanced Non-small Cell Lung Cancer Fox Chase Cancer Center|National Comprehensive Cancer Network December 6, 2009 Phase 1
NCT02108002 Enrolling by invitation Von Hippel-Lindau Disease National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) March 5, 2014 Phase 1
NCT03022565 Not yet recruiting Uveal Melanoma Nicolas Acquavella|University of Miami Sylvester Comprehensive Cancer Center|University of Miami April 2017 --
NCT02943642 Not yet recruiting Mycosis Fungoides Angimmune LLC|City of Hope National Medical Center|Columbia University|Dana-Farber Cancer Institute|Feinberg School of Medicine, Northwestern University|H. Lee Moffitt Cancer Center and Research Institute|Ohio State University Comprehensive Cancer Center|Rush University Medical Center|Scott and White Hospital & Clinic|Yale University|Stanford University|Thomas Jefferson University|University of Arkansas|University of Colorado Denver School of Medicine Barbara Davis Center|University of Texas Southwestern Medical Center|University of Washington|Vanderbilt University School of Medicine|Washington University School of Medicine January 2017 Phase 2
NCT02836548 Recruiting Melanoma|Skin Neoplasms The Netherlands Cancer Institute June 2016 Phase 1|Phase 2
NCT02589145 Recruiting Lymphoma M.D. Anderson Cancer Center|Celgene Corporation June 2016 Phase 1|Phase 2

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

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Tags: Vorinostat (SAHA, MK0683)を買う | Vorinostat (SAHA, MK0683) ic50 | Vorinostat (SAHA, MK0683)供給者 | Vorinostat (SAHA, MK0683)を購入する | Vorinostat (SAHA, MK0683)費用 | Vorinostat (SAHA, MK0683)生産者 | オーダーVorinostat (SAHA, MK0683) | Vorinostat (SAHA, MK0683)化学構造 | Vorinostat (SAHA, MK0683)分子量 | Vorinostat (SAHA, MK0683)代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID