Vorinostat (SAHA, MK0683)

製品コードS1047 別名:SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683)化学構造

分子量(MW):264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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JPY 24402.00
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文献中の使用例(100)

カスタマーフィードバック(20)

  • Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

    D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

製品安全説明書

HDAC阻害剤の選択性比較

生物活性

製品説明 Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
ターゲット
HDAC [1]
(Cell-free assay)
~10 nM
体外試験

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 MVHLbY5ie2ViQYPzZZk> NIr5NosyKGh? MVfEUXNQ MmnvZY51cS2KRFHDNUBi[3Srdnn0fUB4cXSqIFnDOVAhd2ZiMD6xNVIh|ryP NUezZmt2OTF7NkC0PFk>
Friend leukemic cell NVvscYR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELrdJI2OCEQvF2= MXG3NkBp MkT3SG1UVw>? NX\4OIZXUUN3ME2wMlk6KM7:TR?= MVmxNlExQTlzMx?=
K562 MVrLbY5ie2ViQYPzZZk> NHvjTpY3KGh? MYjEUXNQ NFHwd5pKdmirYnn0bY9vKG:oIHj1cYFvKGirc4TvcoUh\GWjY3X0fYxie2ViKH3pfJR2emVib3[gTGRCSzFiYX7kJGhFSUN{KTD3bZRpKEmFNUCgc4YhOC5yMTFOwG0> M2TRTlEzPDF7M{iw
HT1080 Mk\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnRO|IhcA>? M1q3bGROW09? NUDzTG9jUUN3ME2yMlQh|ryP MmrJNVIzPzBzN{W=
H1299 NFr3d|VMcW6jc3WgRZN{[Xl? MX[yNEBucW5? NUGwfo1FTE2VTx?= NVfydVBDUW6qaXLpeI9zgSCjY4Tpeol1gSCjZ3HpcpN1KEiGQVOg[Y57gW2nIIfpeIghUUN3MDDv[kAxNjF7NDFOwG0> MWSxOFUzOTR{Mh?=
H1299 M3vUSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXXVm5uPzJiaB?= MlXnSG1UVw>? M1\0SmlEPTB;Nz6yOEDPxE1? MW[xOFUzOTR{Mh?=
HeLa NXfFW4JXU2mwYYPlJGF{e2G7 NGnhT|U{OCCvaX6= MmC0TY5pcWKrdH;yfUBkd26lZX70doF1cW:wIHHnZYlve3RiaHnzeI9v\SCmZXHj[ZR6dGG|ZTD3bZRpKEmFNUCgc4YhOC5{ODFOwG0> Ml3tNVU3ODN7NEm=
LOX-IMVI NIS3bZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLsOFghcA>? M{HjWWlEPTB;MT6zJO69VQ>? M3Tk[VE2PzF3NEew
NCI-H226 NYjnfFVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2[1dlQ5KGh? NGfScG1KSzVyPUKuOkDPxE1? M4qyOlE2PzF3NEew
RXF-631L NFmyTodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3tOnA1QCCq MYnJR|UxRTJizszN MXixOVcyPTR5MB?=
SNB-78 M3\QXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWC0PEBp NX3BTYdWUUN3ME2xOkDPxE1? MX6xOVcyPTR5MB?=
St-4 M4X1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TI[lQ5KGh? M3W2SGlEPTB;NT6yJO69VQ>? NH64XVgyPTdzNUS3NC=>
ARP1 NXnrb3hPTnWwY4Tpc44hSXO|YYm= MmT6NkDPxE1? NFSwbXI3KGh? NFXkUnRKdmS3Y4Tpc44hd2ZiUEKxW2FHOSCpZX7lJIV5eHKnc4Ppc44> NUS2WXR[OTR5M{S4NFY>
CEM NVnNTW8yU2mwYYPlJGF{e2G7 NUT0WZpROSCq NVe3[opRTE2VTx?= NF;Re3NKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuN|Mh|ryP NGnzeHgyPjR{MEC2OC=>
HCT15 NHL5WW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\3XmpzPDhiaB?= NGq3XYtIUTVyPUCuPFIh|ryP NGHGU2IyPjd{M{KyOy=>
NCI-H23 NEDXcXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPabolKPDhiaB?= NHK5eJFIUTVyPUCuPVIh|ryP MoD2NVY4OjN{Mke=
GM15850 MoT0T4lv[XOnIFHzd4F6 MYSyMlUh|ryP NWjjR3ZxQTZiaB?= NH;hc2NFVVOR M2DZR2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFizJIx6e2mwZTCxOEBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MXexOlkzOTN4Nx?=
GM15850 MVTLbY5ie2ViQYPzZZk> M{nRS|IvPSEQvF2= NFzodVg6PiCq NILhT5JFVVOR M{\nU2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTC1JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n MlfvNVY6OjF|Nke=
GM15850 MWfLbY5ie2ViQYPzZZk> MXeyMlUh|ryP MnLvPVYhcA>? MmnnSG1UVw>? MWDJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViMUKgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? NYTDdJUzOTZ7MkGzOlc>
GM15850 NFnFeI1McW6jc3WgRZN{[Xl? NIX1XHYzNjVizszN MW[5OkBp MXfEUXNQ NGPWRXZKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgPUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MYWxOlkzOTN4Nx?=
GM15850 M{\YWWtqdmG|ZTDBd5NigQ>? NV7DPJZUOi53IN88US=> M3vQNVk3KGh? MnT1SG1UVw>? Mm\GTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEigZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? NV7iPFBrOTZ7MkGzOlc>
GM15850 Ml60T4lv[XOnIFHzd4F6 NFuwNYkzNjVizszN M4TKSFk3KGh? Mnm0SG1UVw>? MlvnTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEG2JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n M{nafFE3QTJzM{[3
U937 NEfOUHhHfW6ldHnvckBCe3OjeR?= M3XzblUh|ryP M{jQWlI1KGh? NUXrZmR[TE2VTx?= NXzqT2ZvS2WubDDjfYNt\SCjcoLld5Qh[nliYXPjeY12dGG2aX;uJIF1KFNxR{KvUUBxcGG|ZR?= MoLvNVcxODR5MUi=
H661 NXyyeox[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfJWmY1QCCq M{TSU2lEPTB;MTFOwG0> M1nBZVE4OTV5MEC5
U937 NFXu[Y5HfW6ldHnvckBCe3OjeR?= MnS1OUDPxE1? M17pNlI1KGh? NVfod4liTE2VTx?= MYXJcoNz\WG|ZTDpckBpcXO2b37lJGg{KGGlZYT5cIF1cW:w M2rhR|E4PDR5N{Ww
U937 NVnuVIEzTnWwY4Tpc44hSXO|YYm= MmPtNUDPxE1? Mlr0NlQhcA>? Ml3oSG1UVw>? MmXOSYZn\WO2IH;uJIFteGijIIT1ZpVtcW5iYXPleJlt[XSrb36= MkjPNVc1PDd5NUC=
RAW264.7 MVXGeY5kfGmxbjDBd5NigQ>? MkS1NVAh|ryP M{j1d|I1cA>? NVj2RmJ5f2G2ZYK= MV;Jcohq[mm2aX;uJI9nKEySUz3zeIlufWyjdHXkJHRPTmGucHjhJJBzd2S3Y4Tpc44hf2m2aDDJR|UxKG:oIECuO|Yh|ryP M4T3ZlE4PDd5NUG4
RAW264.7 MYrGeY5kfGmxbjDBd5NigQ>? M1fncVExKM7:TR?= MXqyOIg> NEG5To14[XSnch?= NF\ue3hKdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKE6RIIDyc4R2[3Srb36ge4l1cCCLQ{WwJI9nKDFwOEig{txO NIW1eoMyPzR5N{WxPC=>
SC9 NVLmSoNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXpc2w1QCCq NXGyNIZCUUN3ME2wMlYxPiEQvF2= MVmxO|UxPzJzOR?=
ST14A MVTGeY5kfGmxbjDBd5NigQ>? NHP3SnU2KG6P NIjI[YU4OiCq MlOyTY5kemWjc3WgbY4hWkWVVD;OVnNHKG2UTlGg[ZhxemW|c3nvci=> NGnCSpAyPzV4NUm5Ny=>
ST14A MkS1SpVv[3Srb36gRZN{[Xl? MWi1JI5O NVTTU5g3PzJiaB?= M1ewdGlv[3KnYYPlJIlvKEV{RkGgcXJPSSCneIDy[ZN{cW:w MWGxO|U3PTl7Mx?=
PANC1 NETCdZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjaeYIyKM7:TR?= MV7JR|UxRTBwNEWg{txO NU\zR5FPOTd3OEi3OFQ>
PANC1 Mly4SpVv[3Srb36gRZN{[Xl? NWDMbpFLOSEQvF2= MV[yOEBp MVHJcoNz\WG|ZTDpckBxOjGZQV[xM2NKWDFiZ3Xu[UBmgHC{ZYPzbY9v M1zMfVE4PTh6N{S0
PANC1 MmXzSpVv[3Srb36gRZN{[Xl? MnfMNUDPxE1? MX:yOEBp MXjJcoNz\WG|ZTDpckBxOjetaYCxJIdmdmViZYjwdoV{e2mxbh?= NVXuNlFNOTd3OEi3OFQ>
PT45 MnnWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPsXYJKSzVyPUSg{txO MWSxO|U5QDd2NB?=
ACHN NXvabYdGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUiyNUBp M13IbmdKPTB;MD62OUDPxE1? M1zFeFE4PjZ{NkC2
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Caco-2 MYrLbY5ie2ViQYPzZZk> NHG5bnE3NjN{IH7NJJRwKDZ|MjFOwG0> MUe0JIg> NWTCN5VCTE2VTx?= NV7sS3Z7TXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVO1JJdqfGhiSVO1NEBw\iBzMj62JO69VQ>? MoHONlAyPDN6NEC=
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HepG2 NXHONnB[U2mwYYPlJGF{e2G7 MlK1OUDPxE1? NGfDU5U3cA>? NInYbFhFVVOR NW\iZnBZUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhcGm|dH;u[UBpgXCncnHj[ZR6dGG2aX;u MYCyNFE1Ozh2MB?=
HepG2 MYfLbY5ie2ViQYPzZZk> NIHyb2E2KM7:TR?= MUG2bC=> M3:5bGROW09? M1LtbWlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJIFteGijLYT1ZpVtcW5iYXPleJlt[XSrb36= M4XkXlIxOTR|OESw
HepG2 NET6[4tMcW6jc3WgRZN{[Xl? NEDoRWQ2KM7:TR?= M{iyZ|Zp NYPVdVR{TE2VTx?= M{XJ[Wlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJGg{N0h2IHjpd5RwdmViYXPleJlt[XSrb36= NV\jVlBlOjBzNEO4OFA>
COLO205 MW\LbY5ie2ViQYPzZZk> MkPBNVAh|ryP MWqyOEBp MUXEUXNQ NHPETXJKdmirYnn0bY9vKG:oIFjERWMyKGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBpcXO2b37lJGg{KGGlZYT5cIF1cW:wIIfpeIghUUN3MDDv[kAzNjJizszN NYPpVWtDOjB2NUGzO|g>
SCC4 MWXLbY5ie2ViQYPzZZk> MX2xJO69VQ>? NU\LfXE5OjSq NXHjUldoUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJJR2[nWuaX6gZYNmfHmuYYTpc44> NVPKWoNwOjB2NUKyNlU>
SCC4 NX\Ec49KU2mwYYPlJGF{e2G7 MYexJO69VQ>? NW[xNIJwOjSq MYDJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCjY3X0fYxifGmxbh?= NXfSRpBxOjB2NUKyNlU>
SCC4 NYnyc4F5TnWwY4Tpc44hSXO|YYm= M1PuTlEh|ryP NULpc3VVPSCvaX6= NYPrVFRHSWexbnnzeEBi[3Srdnn0fUBifCCYRGKgZZN{\XO|ZXSgZZMhcW6mdXP0bY9vKG:oIFPZVFI1KGenbnWg[ZhxemW|c3nvci=> NFfne3UzODR3MkKyOS=>
NB4 NUW3PW9PTnWwY4Tpc44hSXO|YYm= NXT6PHJxPSEQvF2= MV[yOEBp MkfuSG1UVw>? M1PsO2NmdGxiY4njcIUh[XK{ZYP0JIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHHjZ5VufWyjdHnvckBifCCycnWtS|EheGijc3W= MlywNlA1QTF2NEC=
NB4 M{DSR2tqdmG|ZTDBd5NigQ>? Mn2zOUDPxE1? M37OTFI1KGh? MU\EUXNQ MkXxTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHHj[ZR6dGG2ZTD0eYJ2dGmwIHzleoVt Mli3NlA1QTF2NEC=
NB4 MUDGeY5kfGmxbjDBd5NigQ>? MUe1JO69VQ>? M2PsUFI1KGh? MlvjSG1UVw>? M1jobGlv\HWldHnvckBw\iCyMkHXRWYyN0OLUEGg[ZhxemW|c3nvci=> MWqyNFQ6OTR2MB?=
NB4 NUfjeHlFU2mwYYPlJGF{e2G7 NHzzWJo2KM7:TR?= M{DablI1KGh? MUHEUXNQ M2nnOGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFizJIFk\XS7bHH0bY9v MmXDNlA1QTF2NEC=
NUGC3 NEn5cIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HsW2dKPTB;Mj65OEDPxE1? NEe2fHgzODh3MEm3NS=>
A549 NVTtbFR4TnWwY4Tpc44hSXO|YYm= MkjCOUDPxE1? NXXZZoJLOyCq M1zy[mROW09? NWT5[YxzUW6mdXP0bY9vKG:oIHH1eI9xcGGpeTDpckBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIFzDN2lK MVyyNFg2PTJyOB?=
HUT78 MnmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljtO|IhcA>? NFq2epNFVVOR Mkf4S2k2OD1yLkOg{txO M4fuZlIxQDh2MkC4
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A431 M2HTVWN6fG:2b4jpZ{BCe3OjeR?= NXzO[G5HPzJiaB?= NH;EZnBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPDNzIHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGVITlJid3n0bEBKSzVyIH;mJFQvOiEQvF2= MkXUNlExQDB4Mkm=
A549 M4PzS2N6fG:2b4jpZ{BCe3OjeR?= M2LqSFczKGh? NGPnWYxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhFSUNid3n0bEBKSzVyIH;mJFEvQCEQvF2= NH3a[pIzOTB6ME[yPS=>
CAL27 M1f5cWN6fG:2b4jpZ{BCe3OjeR?= NHTycVA4OiCq MoLiR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR2FNOjdiY3XscJMhd3[ncnX4dJJme3OrbnegSWdHWiC5aYToJGlEPTBib3[gN{4zKM7:TR?= Mn;iNlExQDB4Mkm=
HeLa NWO5[XFPS3m2b4TvfIlkKEG|c3H5 M{LKd|czKGh? MoDZR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISGFEKHerdHigTWM2OCCxZjCxMlUh|ryP M3XzcFIyODhyNkK5
Sf21 NV72PVlIU2mwYYPlJGF{e2G7 NVrrXFhIOyCq NUS5cYVGUW6qaXLpeIlwdiCxZjDGcIFoKHSjZ3fl[EBpfW2jbjDy[YNwdWKrbnHueEBJTEGFODDlfJBz\XO|ZXSge4l1cCCLQ{WwJI9nKDFwMjFOwG0> NFnOPWMzOTB6ME[yPS=>
SKBR3 NU[3Wo1OS3m2b4TvfIlkKEG|c3H5 MkPDO|IhcA>? MX3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT2JTOyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISXIzKHerdHigTWM2OCCxZjCyMlYh|ryP M1HC[lIyODhyNkK5
SKOV3 NFPJO5NEgXSxdH;4bYMhSXO|YYm= MWC3NkBp NYCyRpB2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uRVkOgZ4VtdHNib4\ldoV5eHKnc4PpcochUEWUMjD3bZRpKEmFNUCgc4YhOi5{IN88US=> Mlr1NlExQDB4Mkm=
COR-L23 NV;IbWhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoToNVAh|ryP MnL0O|IhcA>? M3nxW2ROW09? NE\C[JRIUTVyPUGuNUDPxE1? MmXHNlExQDB4NEe=
DU145 M3z1PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmS2NVAh|ryP MWK3NkBp NFvnOolFVVOR M3nLe2dKPTB;MT6wOUDPxE1? NIHn[2kzOTB6ME[0Oy=>
LoVo MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\zToMyOCEQvF2= MmrwO|IhcA>? NVTOZ5FzTE2VTx?= MlXVS2k2OD1zLkeg{txO M1TQUlIyODhyNkS3
MCR5-SV2 NX:yelByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWSxNEDPxE1? NV\rRop5PzJiaB?= NFzjNnFFVVOR Ml;LS2k2OD1{LkGg{txO MWKyNVA5ODZ2Nx?=
HCT116 NUj6bZZuU2mwYYPlJGF{e2G7 MlzlN|Ah|ryP MlHrN|AhcA>? Ml:5SG1UVw>? M{DRT2lvcGmkaYTpc44hd2ZiSFTBR|Yh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIFteGijLYT1ZpVtcW5iYXPleJlt[XSrb36= Mke5NlExQDB4NEe=
HCT116 NEfvRXNMcW6jc3WgRZN{[Xl? NFT4UmQ{OCEQvF2= NUnyfYlOOzBiaB?= M1rVbmROW09? MUjJcohq[mm2aX;uJI9nKEiGQVOxJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDobZN1d26nIFizT|kh[WOndInsZZRqd25? NXWxO5VVOjFyOEC2OFc>
U937 MVvLbY5ie2ViQYPzZZk> MUO1JO69VQ>? M2jidlI1KGh? NHLLWohFVVOR M3vpemlvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBi[2W2eXzheIlwdiCxZjDobZN1d26nIFizJIF1KEt7 MXWyNVI6OjR7Mh?=
U937 MWXLbY5ie2ViQYPzZZk> MnPVOUDPxE1? NYnzUm9POjRiaB?= M4Ozb2ROW09? MoqxTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJIFk\XS7bHH0bY9vKG:oIHjpd5RwdmViSEOgZZQhUzF6 NX20V2ZuOjF{OUK0PVI>
U937 NHi2WoFMcW6jc3WgRZN{[Xl? MV61JO69VQ>? NVf5d3ZzOjRiaB?= NXTHTpE6TE2VTx?= Ml3vTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJJBidi2jY3X0fYxifGWmIHjpd5RwdmViSESgcIV3\Wx? MV6yNVI6OjR7Mh?=
U937 NGjDfnFMcW6jc3WgRZN{[Xl? MkD6OUDPxE1? MlvLNVUhdWmw NEHKT4FFVVOR NUfDXmtEUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGirc4TvcoUhUDNiYXPleJlt[XSrb36gcIV3\Wx? M3r2XVIyOjl{NEmy
A2780 M2PYSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrwTm51QTZiaB?= NWnzPZZCTE2VTx?= Ml:yTWM2OD1zLk[yJO69VQ>? NFrYW40zOTZ|NESzNC=>
COLO205 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHj6fmk6PiCq NIPjWo5FVVOR NELSd5NKSzVyPUKuNVIh|ryP MV6yNVY{PDR|MB?=
Hep3B Mn\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEK2cYY1QCCq M1TVR2ROW09? MW\HTVUxRTFwMkGg{txO NYHUXJdmOjF5MUKxOFY>
GM11272 MlXWSpVv[3Srb36gRZN{[Xl? M37wZlExOCCwTR?= NXKwdI5kPzJiaB?= NHTo[FhFVVOR MV7S[YFkfGm4YYTpc44hd2ZiTXXDdFIhdXW2YX70JIV5eHKnc4Ppc44h[XRiMUCgeI8hOTByIH7N NF[2XI0zOTh2MEexOi=>
CFBE41o M4TQ[2tqdmG|ZTDBd5NigQ>? NV;PbIFnPSEQvF2= MV7EUXNQ MoTESI94diC{ZXf1cIF1cW:wIH;mJGhFSUN5IHH0JFAvOiC2bzC1JJVO M3PKS|IyQTh2OUW4
CFBE41o M4XVS2Z2dmO2aX;uJGF{e2G7 M{TDT|Eh|ryP NGPoNlczPCCq NUS2b2JQTE2VTx?= M{T2O3Jme3SxcnH0bY9vKG:oIFPGWHIh\GWudHHGOVA5KG23dHHueEB1emGoZnnjb4lv\yC2bzDj[YxtKHO3cn\hZ4Uh[XNiZ3z5Z49nd3Kvcx?= MkjmNlE6QDR7NUi=
DU145 MV7LbY5ie2ViQYPzZZk> M3XidVIvPSEQvF2= NIDKfGUzPCCq NYDORVIxTE2VTx?= MlzITY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KHWycnXneYxifGmxbjDv[kBxOjG5YX[xJJBzd3SnaX6g[ZhxemW|c3nvci=> NF3DOZIzOjJ4MEG2Oi=>
DU145 NVO0d4ExU2mwYYPlJGF{e2G7 MnvROUDPxE1? MYCyOEBp M{fodGROW09? NELKSHFKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaHnzeI9v\SCKNDDhZ4V1gWyjdHnvci=> Mnq0NlIzPjBzNk[=
DU145 MlPUT4lv[XOnIFHzd4F6 NWnSbGo6PSEQvF2= MUWyOEBp M2nMTGROW09? NWn6OmdrUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHjpd5RwdmViSEOgbJlx\XKjY3X0fYxifGmxbh?= MVuyNlI3ODF4Nh?=
786-0 MofYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnqUYE3NjJizszN MWO3NkBp NUjzNXhJTE2VTx?= M{D0UmdKPTB;Mz6yJO69VQ>? NYP6O4RtOjJ2M{W2Olk>
A498 M4D1b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXJSYN2Pi5{IN88US=> M2HIRVczKGh? NVjETno4TE2VTx?= MWTHTVUxRTFwNjFOwG0> NF\hc2wzOjR|NU[2PS=>
A549/ATCC M3GydGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XwN|YvOiEQvF2= NE[3U4o4OiCq MkjLSG1UVw>? NWrYZYZkT0l3ME2xMlYh|ryP NX\IVFVbOjJ2M{W2Olk>
ACHN NULrTIFST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3THe|YvOiEQvF2= MUK3NkBp MYjEUXNQ Mor4S2k2OD1zLkOg{txO NEjMW4QzOjR|NU[2PS=>
BT549 M1zje2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkKyOk4zKM7:TR?= Ml;kO|IhcA>? Mn3TSG1UVw>? NF\OfFFIUTVyPUGuN{DPxE1? M4fDW|IzPDN3Nk[5
EKVX MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVK1SZU4Pi5{IN88US=> MkDWO|IhcA>? MWTEUXNQ MVrHTVUxRTFwMzFOwG0> NHLqT24zOjR|NU[2PS=>
HCT15 M4PDSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rWT|YvOiEQvF2= NX\wVXJiPzJiaB?= MlvsSG1UVw>? MlPCS2k2OD1{LkWg{txO M{nXZ|IzPDN3Nk[5
HOP92 M{njZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\0Z4k3NjJizszN MmCzO|IhcA>? M4jTe2ROW09? M3PkO2dKPTB;NDFOwG0> NUTzO3R4OjJ2M{W2Olk>
IGROV1 NHPwdJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfabVBDPi5{IN88US=> NX3pSXU2PzJiaB?= M{n1fGROW09? MkfuS2k2OD1zLkOg{txO NXvKTG5MOjJ2M{W2Olk>
LOXIMVI NITIOJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rwPFYvOiEQvF2= M3fZVlczKGh? NX;5[3NmTE2VTx?= MWHHTVUxRTFizszN NWnP[2hyOjJ2M{W2Olk>
M14 Mli2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWS2MlIh|ryP M1r5ZVczKGh? M{XRNWROW09? M4e3dGdKPTB;MT6zJO69VQ>? MnryNlI1OzV4Nkm=
MALME-3M MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjCNHQ3NjJizszN MVm3NkBp MoThSG1UVw>? MmXVS2k2OD1yLkOyJO69VQ>? NUDpbJl1OjJ2M{W2Olk>
MCF10A MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfS[GY3NjJizszN NXX3fY5jPDhiaB?= NVSwV4RITE2VTx?= NI\LcJdIUTVyPUmuOkDPxE1? MXuyNlQ{PTZ4OR?=
MDA-MB-435 NEXGUGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\i[4twPi5{IN88US=> MmDsO|IhcA>? MUXEUXNQ NEnm[GZIUTVyPUCuOUDPxE1? NF;v[oYzOjR|NU[2PS=>
MDA-MB-468 M3nNeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYe2MlIh|ryP NYflN3dbPzJiaB?= M1rIWWROW09? Ml7RS2k2OD1yLk[zJO69VQ>? M1rMUVIzPDN3Nk[5
MOLT4 NYezXm83T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17TeVYvOiEQvF2= NF;VS5U4OiCq M4PjVGROW09? NWDCb4NnT0l3ME2wMlQh|ryP NVTrWlVwOjJ2M{W2Olk>
NCI-ADR-RES NXLSV|lkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rMSlYvOiEQvF2= MU[3NkBp MUnEUXNQ MonSS2k2OD1yLkG2JO69VQ>? M3TWdVIzPDN3Nk[5
NCI-H23 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3n5bFYvOiEQvF2= M2fLcVczKGh? MV\EUXNQ NUC2dmtHT0l3ME2xJO69VQ>? NGnId|gzOjR|NU[2PS=>
NCI-H322M M3H2OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUi2MlIh|ryP M4DDeVczKGh? MX7EUXNQ Ml\OS2k2OD1yLke5JO69VQ>? MoX3NlI1OzV4Nkm=
NCI-H460 Ml3YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzZOk4zKM7:TR?= NHjHO|Y4OiCq Mlv2SG1UVw>? MnzPS2k2OD1yLke5JO69VQ>? Ml7XNlI1OzV4Nkm=
NCI-H522 NHL0cm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkO1Ok4zKM7:TR?= MV[3NkBp MWLEUXNQ MYrHTVUxRTBwNTFOwG0> NIDrZ3YzOjR|NU[2PS=>
OVCAR3 MnXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUT2dpZqPi5{IN88US=> NXvxW4ZVPzJiaB?= MmHCSG1UVw>? NWjkSngyT0l3ME2xMlMh|ryP MYiyNlQ{PTZ4OR?=
OVCAR4 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPiUWU3NjJizszN NG\xbWU4OiCq MUDEUXNQ M2DhVWdKPTB;NDFOwG0> NFPidVEzOjR|NU[2PS=>
OVCAR5 MoXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTpOk4zKM7:TR?= NWW4eWRlPzJiaB?= NGqyNVVFVVOR MlfvS2k2OD1yLke5JO69VQ>? NY\UUIlzOjJ2M{W2Olk>
OVCAR8 Mk\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH61VJM3NjJizszN MnnxO|IhcA>? Ml\tSG1UVw>? MkG0S2k2OD1yLkWg{txO M3vhbFIzPDN3Nk[5
RXF393 NX7O[WpbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2ixfFYvOiEQvF2= Ml;BO|IhcA>? M{DWVGROW09? M2ToeGdKPTB;MT6zJO69VQ>? M3PHeVIzPDN3Nk[5
SF268 MmfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfKOk4zKM7:TR?= M2KxcVczKGh? NFLNbJRFVVOR MojaS2k2OD1zLk[g{txO NET6ToYzOjR|NU[2PS=>
SF295 NWnBTHI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVK2MlIh|ryP M2j1UFczKGh? NXXVUmY{TE2VTx?= MV\HTVUxRTFwNjFOwG0> M2TLTFIzPDN3Nk[5
SF539 NVPRc3FRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrCU4ZFPi5{IN88US=> MoC0O|IhcA>? Mmj3SG1UVw>? NYLkbVRTT0l3ME2yJO69VQ>? MnvCNlI1OzV4Nkm=
SK-MEL-2 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\ROk4zKM7:TR?= MUW3NkBp Mo\lSG1UVw>? M4jBNmdKPTB;MT6zJO69VQ>? MVGyNlQ{PTZ4OR?=
SK-MEL-28 NVmwcm9QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXy2MlIh|ryP M1X2[FczKGh? MV\EUXNQ M4qxV2dKPTB;MTFOwG0> NF3wS2MzOjR|NU[2PS=>
SK-MEL-5 M2nibWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\zNWI3NjJizszN M{WwfFczKGh? NGe4XoxFVVOR NITlUGpIUTVyPUCuOlMh|ryP MkXLNlI1OzV4Nkm=
SKOV3 NIDjd4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDmOk4zKM7:TR?= NHqwTIo4OiCq MlvqSG1UVw>? MlHjS2k2OD1zIN88US=> M{f2bVIzPDN3Nk[5
SN12C NUHvOopyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUO2MlIh|ryP MXS3NkBp M3PsbWROW09? NY\qSGQyT0l3ME2yJO69VQ>? NIXK[ZYzOjR|NU[2PS=>
SNB19 MmjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XPWFYvOiEQvF2= Mo\HO|IhcA>? MXfEUXNQ NFfYOWZIUTVyPUCuOlMh|ryP M2rOeVIzPDN3Nk[5
SNB75 NV7mTlNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTz[|BUPi5{IN88US=> MkX6O|IhcA>? NYD1WnpKTE2VTx?= MnvXS2k2OD1yLke5JO69VQ>? NVOyZW9oOjJ2M{W2Olk>
SR M4DzTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYO2MlIh|ryP NEDIb4I4OiCq MlzESG1UVw>? MnvUS2k2OD1yLkSg{txO M{CwfFIzPDN3Nk[5
T47D MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DlR|YvOiEQvF2= NE\lUWU4OiCq NVzQTZpzTE2VTx?= M3uxRWdKPTB;MD61JO69VQ>? M3TGcFIzPDN3Nk[5
TK10 NWn1TXlVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXzTG9yPi5{IN88US=> M3zPO|czKGh? NFnDW5JFVVOR Mn;FS2k2OD1yLk[zJO69VQ>? NU\YNYZZOjJ2M{W2Olk>
UACC257 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jQe|YvOiEQvF2= NV\iTWpOPzJiaB?= MkO3SG1UVw>? MWrHTVUxRTBwNTFOwG0> M{SyblIzPDN3Nk[5
UACC62 M1LjVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX:2MlIh|ryP MlLCO|IhcA>? M{\DemROW09? M1XJXGdKPTB;MD60JO69VQ>? M4\MOlIzPDN3Nk[5
UO31 NETRW3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TpU|YvOiEQvF2= M{HyWVczKGh? M2L5NGROW09? MYLHTVUxRTBwNTFOwG0> NHrWdHczOjR|NU[2PS=>
Hep3B NVrDd49LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWG0PEBp MoPLSG1UVw>? M2frVmdKPTB;MD62PUDPxE1? MnzTNlI1Ozl6NkO=
BE(2)-C M2XRT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF60PXQ4OiCq M3nmT2ROW09? NWHjb|ZOUUN5ME2yJO69VQ>? MWWyNlk{OjNzNh?=
Bel7402 NX;4S41kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPqcYxVPzJiaB?= NW[wUohwTE2VTx?= NIHLPWVIUTlyPUG3JO69VQ>? MkjhNlMxPjF|N{[=
Bel7404 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3yWpZkPzJiaB?= NHX4WFBFVVOR NWXMeIZiT0l7ME2xPEDPxE1? MUOyN|A3OTN5Nh?=
BGC823 MmDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HpWlczKGh? NEjQSWpFVVOR NVft[nFpT0l7ME23MlUh|ryP MUSyN|A3OTN5Nh?=
MGC803 Mlz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUG3NkBp Mof1SG1UVw>? Ml3ZS2k6OD1zMD64JO69VQ>? NE\ISYwzOzB4MUO3Oi=>
SGC7901 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWG3NkBp NX\S[ZRVTE2VTx?= M4DYTGdKQTB;OT60JO69VQ>? NU\vSZpXOjNyNkGzO|Y>
SKHEP1 M1\zPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7XO|IhcA>? MUPEUXNQ NWjpelNiT0l7ME2xO{DPxE1? M2q1bFI{ODZzM{e2
SMMC7721 NX;qT5JjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYG3NkBp M3u5XWROW09? M1HxeGdKQTB;MkCg{txO MoPUNlMxPjF|N{[=
NUGC3 MnW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XKZ|ExKM7:TR?= NVnhV4ZwT0l;Mj65OEDPxE1? MYWyN|E3OzN|Mh?=
A2780 CisR NHjj[GRMcW6jc3WgRZN{[Xl? MnHuNVghcA>? NF;tU4xKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOFQh|ryP NYLIRm9LOjN{NUK2NFM>
CAL27 sens NHXl[WRMcW6jc3WgRZN{[Xl? MXOxPEBp NWHHT246UW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlM3KM7:TR?= NUfxb2FmOjN{NUK2NFM>
CAL27 CisR MWPLbY5ie2ViQYPzZZk> M2LXeFE5KGh? NWO1c2MzUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?= M1jUUlI{OjV{NkCz
KYSE-510 CisR M1;SemtqdmG|ZTDBd5NigQ>? MkTvNVghcA>? M{XNTGlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD61PUDPxE1? NGXa[ogzOzJ3Mk[wNy=>
KYSE-510 sens NUXIT2tzU2mwYYPlJGF{e2G7 NFvKelEyQCCq NF7qcJlKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuO{DPxE1? M3nST|I{OjV{NkCz
MDA-MB-231 sens M1XGS2tqdmG|ZTDBd5NigQ>? M1rU[|E5KGh? MUfJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO NG\n[mUzOzJ3Mk[wNy=>
MDA-MB-231 CisR M2i3bmtqdmG|ZTDBd5NigQ>? MnPTNVghcA>? Ml7mTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>? MXeyN|I2OjZyMx?=
ES2 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHUOFghcA>? MYDEUXNQ NIrkZ|VKSzVyPUGyMlch|ryP NULPZ5o2OjN2OUO0OFk>
MDA-MB-231 M4LRXWtqdmG|ZTDBd5NigQ>? NUTVN|lHOTBizszN M1;jW|MxKG2rbh?= M3LPWWROW09? NIWxPXJKdmirYnn0bY9vKG:oIFjERWMz[Q>? NFHhV|EzOzR7M{S0PS=>
MDA-MB-231 NFf2b3FMcW6jc3WgRZN{[Xl? MnTvNUDPxE1? M2\VOlI1KGh? NFvIRWRFVVOR MnTaTY5pcWKrdHnvckBw\iCKRFHDOkBie3Onc4Pl[EBieyCjY3X0fYxifGmxbjDs[ZZmdHNib3[geJVjfWyrbh?= MYmyN|Q6OzR2OR?=
HS68 M1jWPGN6fG:2b4jpZ{BCe3OjeR?= NH7lSVMyOCEQvF2= NHn1SZo4OiCq NV7Q[opRTE2VTx?= NYCwZ2l6UUN3ME20MlYh|ryP NFPKUYIzOzV5MEW0Ni=>
MEF MYjDfZRwfG:6aXOgRZN{[Xl? NEPZcYoyOCEQvF2= NUnUXINKPzJiaB?= MmrWSG1UVw>? M1HOOGlEPTB;ND60JO69VQ>? NUP0SFNoOjN3N{C1OFI>
BGC823 NX7xVYhRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTpSG1UVw>? M1rRS2dKPTB;Mz6wPUDPxE1? NX[yfYRqOjN4MEG3NFY>
High5 M{jQfmtqdmG|ZTDBd5NigQ>? NUTKVok2OjRiaB?= NYPRcHRkUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEPiC5aYToJGlEPTBib3[gNE4xQSEQvF2= MUCyN|YxOjV{Mx?=
High5 MYPLbY5ie2ViQYPzZZk> NYXUWHd1OjRiaB?= MlXFTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCKRFHDNUB4cXSqIFnDOVAhd2ZiMD6xNkDPxE1? MUGyN|YxOjV{Mx?=
High5 Mn7CT4lv[XOnIFHzd4F6 NFLCNIkzPCCq NImxTolKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM{KHerdHigTWM2OCCxZjCwMlE4KM7:TR?= NVLudmRwOjN4MEK1NlM>
A549 NYP0OpNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXP3[I1ETE2VTx?= M4Ty[GlEPTB;MT6wO|kh|ryP MlPwNlM3PDR{MUC=
HCT116 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHHR2dFVVOR MUHJR|UxRTBwN{W3JO69VQ>? M3XMRVI{PjR2MkGw
K562 NUfqU5dDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfuNnNYTE2VTx?= MXvJR|UxRTBwNkS1JO69VQ>? M{nIb|I{PjR2MkGw
GBC-SD NELuU4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13nbFUh|ryP NEfXTJQ4OiCq M4D2VGROW09? NIHCSmpKSzVyPUG0Mlgh|ryP MmDoNlM4ODd{NkC=
HGC27 M3nvZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPNV2VMPSEQvF2= NGXuXoo4OiCq NYnneY9UTE2VTx?= MWTJR|UxRTVwNDFOwG0> NEjjbXIzOzdyN{K2NC=>
HL60 NEDLUotMcW6jc3WgRZN{[Xl? NVrhOlk6PSEQvF2= NETuSXAzPCCq M1vQOGROW09? NFi3WmZKdmirYnn0bY9vKG:oIFjERWM> NX\oXWRpOjN5MEeyOlA>
Vero M{X3bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17Vc|czKGh? MlfZSG1UVw>? MX7JR|UxRTBwOTFOwG0> NInOWWEzOzd6NkS1Ni=>
NCI60 MYnDfZRwfG:6aXOgRZN{[Xl? NFvxVFA1QCCq M3fsXGROW09? NXPldHJ{T0l;MD61N{DPxE1? Mn3sNlQxOTV|Mke=
SW620 MmjTR5l1d3SxeHnjJGF{e2G7 NIi4U5A1QCCq NFn4U29FVVOR NWPPdGFNT0l;MD61OEDPxE1? NFq1d5MzPDBzNUOyOy=>
U251 NUfxZW9XS3m2b4TvfIlkKEG|c3H5 NYnP[HY1PDhiaB?= NIDRWmdFVVOR NYDJ[JdYT0l;MT61N{DPxE1? NUnR[JNQOjRyMUWzNlc>
KM12 M3v2[GN6fG:2b4jpZ{BCe3OjeR?= NHTxb5A1QCCq NWfNPY1iTE2VTx?= M4LuSGdKRTFwOEig{txO NIjFPI8zPDBzNUOyOy=>
Hs578T M4nBSWN6fG:2b4jpZ{BCe3OjeR?= M{fNWVQ5KGh? MnHmSG1UVw>? M1ixXWdKRTRwOEOg{txO NI\qTlczPDBzNUOyOy=>
MDA-MB-231 NEe1ephIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrHVY1vPDhiaB?= M3u1ZmlEPTB;MD6xOkDPxE1? NIjiTmQzPDB7NUCxOi=>
MCF7 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYW0PEBp NGXmNmpIUT1yLkS1JO69VQ>? MmLDNlQyOTl3NUW=
MDA-MB-435 M3[4ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfOcYFDPDhiaB?= NEfNSndIUT1yLki4JO69VQ>? M4jDUFI1OTF7NUW1
AsPC1 M1TqPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWSzNEDPxE1? MUK0PEBp M3vNUWROW09? M1rZTWlEPTB;Mz62OkDPxE1? M4q0N|I1OTh3M{e4
Jurkat E6.1 M3rDZWtqdmG|ZTDBd5NigQ>? MXKyJIg> MnvnSG1UVw>? NGXKSIxKdmirYnn0bY9vKG:oIFjERWM1KHerdHigTWM2OCCxZjCwMlA1KM7:TR?= NYDDWnI6OjR{NkG4OlI>
KG1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWq0PEBp NU\nR2ZrUUN3ME2xMlE2KM7:TR?= MXOyOFUzPTByMx?=
HEL MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DjNFQ5KGh? MXnEUXNQ MmDYTWM2OD1yLkS5JO69VQ>? MnjjNlQ3QTRyNUW=
HSC3 NXPPcWY{S3m2b4TvfIlkKEG|c3H5 NEHjcJUyOiCq MUDEUXNQ M{jKc2lEPTB;MD63NUDPxE1? NF3vOoszPDd4NkW2NC=>
HT-29 MWnDfZRwfG:6aXOgRZN{[Xl? M{DXVVEzKGh? NY\tcJp{TE2VTx?= NVzYTIpRUUN3ME2wMlczKM7:TR?= NHW5RoQzPDd4NkW2NC=>
KB NHfjTm9EgXSxdH;4bYMhSXO|YYm= MXuxNkBp MYfEUXNQ NUX3bJpyUUN3ME2wMlc2KM7:TR?= NHi1N4YzPDd4NkW2NC=>
H460 MX3DfZRwfG:6aXOgRZN{[Xl? NVPPc|NxOTJiaB?= NUW0TVFYTE2VTx?= M1npWWlEPTB;MD64NkDPxE1? NVPUPWhEOjR5Nk[1OlA>
MONE1 MlnUR5l1d3SxeHnjJGF{e2G7 MnnyNVIhcA>? NYfyRVBGTE2VTx?= NV3LTVFIUUN3ME2xMlE5KM7:TR?= MYWyOFc3PjV4MB?=
MKN45 MWnDfZRwfG:6aXOgRZN{[Xl? MWexNkBp NIDrOI1FVVOR MWPJR|UxRTFwMkWg{txO M4LUZlI1PzZ4NU[w
TSGH MlXqR5l1d3SxeHnjJGF{e2G7 M3rFV|EzKGh? NUnJXXN[TE2VTx?= M1[4OmlEPTB;Mj6wPUDPxE1? NGfDV3ozPDd4NkW2NC=>
HL60 NF3lPItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\mUHc4OiCq NVO4R4JZTE2VTx?= MWHHTVUxRTBwOUOg{txO M3rr[VI1QTByNUCw
HEK293 NGDE[YJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELTfpI4OiCq MWnEUXNQ M2ThcGdKPTB;MUOg{txO NW\kNFhHOjR7MEC1NFA>
Jurkat MX7DfZRwfG:6aXOgRZN{[Xl? MkfFNVAxKM7:TR?= NV\jVo5uPzJiaB?= MofqS2k2OD1yLkmg{txO MYKyOFkxODd2Mx?=
GM15850 NFHrVWdMcW6jc3WgRZN{[Xl? M3jqSVIvPSEQvF2= NWTNZow6QTZiaB?= NYrkS|d3TE2VTx?= MmTJ[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFE1KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MnfYNVY6OjF|Nke=
GM15850 NXjtZ|V1U2mwYYPlJGF{e2G7 Mlq2Nk42KM7:TR?= Mmq3PVYhcA>? MY\EUXNQ MXnkc4V{KG6xdDDpcohq[mm2IFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgOUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MW[xOlkzOTN4Nx?=
GM15850 NVuzWHNGU2mwYYPlJGF{e2G7 M3HWdFIvPSEQvF2= NYDRN|E3QTZiaB?= M2K4emROW09? NXrtOW1i\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDRibInzbY5mKDF{IHHj[ZR6dGG2aX;uJI9nKE[[TjDn[Y5m NUW3UI43OTZ7MkGzOlc>
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HCT-116 NWDpbo02T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTFwMUe3OUDPxE1? NVnFW5dIW0GQR1XS
MC-IXC MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfYUIRKSzVyPUGuNVc5QDFizszN M4jvNXNCVkeHUh?=
LB1047-RCC NXXjNIdOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjVSHRKSzVyPUGuNVg{OTJizszN NHjKWIlUSU6JRWK=
VM-CUB-1 NX31fJZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\3TWM2OD1zLkG5NVA5KM7:TR?= MlLVV2FPT0WU
NB5 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PZSWlEPTB;MT6xPVg2PiEQvF2= M2LhdnNCVkeHUh?=
SKG-IIIa NIP4XIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFSzbIJKSzVyPUGuNlM1PjRizszN MXPTRW5ITVJ?
HO-1-N-1 MlnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1P6SWlEPTB;MT6yN|g{PSEQvF2= NYrnTHI3W0GQR1XS
EFO-27 NFHRSnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXCcWtKSzVyPUGuNlUxPDNizszN M3HuR3NCVkeHUh?=
MHH-NB-11 MlXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrWTWM2OD1zLkK4N|I6KM7:TR?= M{WybnNCVkeHUh?=
SW620 NWrsRVVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTnTWM2OD1zLkK5NFE5KM7:TR?= MXHTRW5ITVJ?
MOLT-16 NXnSVGFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moq1TWM2OD1zLkK5O|k4KM7:TR?= M1\lV3NCVkeHUh?=
NTERA-S-cl-D1 NFG5UmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLPTWM2OD1zLkOxO|YyKM7:TR?= NYfuVIoxW0GQR1XS
VA-ES-BJ MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTh[JdKSzVyPUGuN|I1PzdizszN NGi4cWlUSU6JRWK=
HCC1419 NU[4doprT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI[2RWJKSzVyPUGuN|QxOjdizszN NHL0cYlUSU6JRWK=
NCI-H69 MljSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTFwM{SxNVIh|ryP M1jTUnNCVkeHUh?=
DEL NHzM[5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTFwM{WxOlIh|ryP M4Kxd3NCVkeHUh?=
LXF-289 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfuNolsUUN3ME2xMlM2OjRizszN NWGxV4FlW0GQR1XS
EW-11 NF;oRXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nLTGlEPTB;MT6zOlAzPiEQvF2= M2i0R3NCVkeHUh?=
KP-4 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFm2ZXNKSzVyPUGuN|cxQDVizszN NHTyWJhUSU6JRWK=
NOS-1 NVn6d|BiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DNNmlEPTB;MT60NVE6PCEQvF2= NEO0TZpUSU6JRWK=
SK-NEP-1 M2[4V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXNfFYyUUN3ME2xMlQyPjl|IN88US=> NXLlfVVqW0GQR1XS
LAMA-84 NEDZcY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTWSIxKSzVyPUGuOFM6PDVizszN MlTGV2FPT0WU
ES5 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDZTWM2OD1zLkS0N{DPxE1? NGrnSIRUSU6JRWK=
HuO9 NHPqVWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1njb2lEPTB;MT60OVM3OiEQvF2= MUnTRW5ITVJ?
COLO-684 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{W4XmlEPTB;MT60OlEyQCEQvF2= Mk\IV2FPT0WU
EW-24 M2fuPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTFwNE[1N|Eh|ryP MYnTRW5ITVJ?
BV-173 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPzTWM2OD1zLkS3NlkyKM7:TR?= MlK3V2FPT0WU
NCI-H1770 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjJWHpKSzVyPUGuOFg2OzZizszN MWLTRW5ITVJ?
HuP-T4 NFnGUWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTFwNEmzJO69VQ>? NV7LbFJ1W0GQR1XS
TYK-nu M4T1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX36bJNmUUN3ME2xMlQ6QDVzIN88US=> NW\CVFZ2W0GQR1XS
YH-13 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTFwNEm4PVQh|ryP Mn3jV2FPT0WU
H4 M{\4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTFwNUC5NVIh|ryP NX:2flJ2W0GQR1XS
OVCAR-8 MoL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnL1TWM2OD1zLkW0OFc4KM7:TR?= NITLTWlUSU6JRWK=
NCI-H23 MljzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXH[ZhKSzVyPUGuOVQ3PDVizszN NHn5fYpUSU6JRWK=
ES7 M4fEcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4j0XGlEPTB;MT61OFc4OyEQvF2= Mn3zV2FPT0WU
COR-L88 M3;z[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTFwNU[0NlQh|ryP MmHZV2FPT0WU
TI-73 MmrPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkj4TWM2OD1zLkW5NFYh|ryP MlHMV2FPT0WU
RT-112 M3;jOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3lUmNKSzVyPUGuOVkzQDRizszN NF\5VotUSU6JRWK=
HuO-3N1 MkfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nHcGlEPTB;MT61PVM5PSEQvF2= NF:yWIJUSU6JRWK=
HC-1 NHn0eJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF25OZlKSzVyPUGuOVk5PjZizszN NYexXGtZW0GQR1XS
HT55 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDaU4lyUUN3ME2xMlY2OTNzIN88US=> NYD0UXV5W0GQR1XS
IA-LM NHzndoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTFwNkmyO|gh|ryP MnW0V2FPT0WU
EM-2 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{niTmlEPTB;MT63NFAyPCEQvF2= Mk\oV2FPT0WU
MHH-ES-1 Mk\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHBTWM2OD1zLkewOFM2KM7:TR?= M4P5RXNCVkeHUh?=
CAL-27 Mo\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PpVmlEPTB;MT63NFYzOSEQvF2= NHrDcWZUSU6JRWK=
COLO-800 NHHDcVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3SwbGlEPTB;MT63NVE4QSEQvF2= MnvFV2FPT0WU
HCE-T M3nxdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTFwN{G1JO69VQ>? NHrpfnhUSU6JRWK=
CAMA-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTFwN{G5O|Eh|ryP Mkf3V2FPT0WU
LOXIMVI MlvwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LsOmlEPTB;MT63NlEyKM7:TR?= M2W0UHNCVkeHUh?=
NH-12 NGj0elZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHocopKSzVyPUGuO|I3QTFizszN NGO4PHJUSU6JRWK=
TCCSUP NUPqTHJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\WXGpKSzVyPUGuO|I5OjlizszN NEK3ZYhUSU6JRWK=
MDA-MB-361 MnPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DZW2lEPTB;MT63N|E2PyEQvF2= M2nXPHNCVkeHUh?=
EW-16 M2\xW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\FTXl7UUN3ME2xMlc1OTB5IN88US=> MkLRV2FPT0WU
SNU-423 M1H5Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzWTWM2OD1zLke1PFI4KM7:TR?= NYj3dnVQW0GQR1XS
Daoy NVfmZ|dlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mli1TWM2OD1zLke2N|E6KM7:TR?= NIr6O2lUSU6JRWK=
ES4 NH7sSmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTFwN{i3OFEh|ryP M2DJNXNCVkeHUh?=
PFSK-1 M4ftO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fwT2lEPTB;MT64NFM4KM7:TR?= MUHTRW5ITVJ?
ES3 NVizUWQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLmdo9tUUN3ME2xMlgzPjhzIN88US=> MofPV2FPT0WU
ONS-76 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvJTWM2OD1zLkiyPFk4KM7:TR?= MojuV2FPT0WU
JVM-3 NVy3RXJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37xNWlEPTB;MT64OVQ2OSEQvF2= NHrWNIFUSU6JRWK=
OS-RC-2 NYfUb|ByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjNeHpKSzVyPUGuPFcyPTFizszN MkLpV2FPT0WU
COLO-320-HSR MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTjTWM2OD1zLki4NVk4KM7:TR?= MUXTRW5ITVJ?
HN M3TEO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnX5TWM2OD1zLki4O|I2KM7:TR?= NGTMUHpUSU6JRWK=
HT M2L3emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLuTWM2OD1zLki4PVQ4KM7:TR?= Mki3V2FPT0WU
LoVo M33XRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTFwOEm4NUDPxE1? NH\Rd5FUSU6JRWK=
CGTH-W-1 NH;CeHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTFwOEm5OFYh|ryP NGjtNGlUSU6JRWK=
NB6 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHSUVBKSzVyPUGuPVEzQThizszN MnXBV2FPT0WU
EW-22 NGPafpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHuwTJFKSzVyPUGuPVI5QDdizszN MUDTRW5ITVJ?
ES6 M{HyS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrjTWM2OD1zLkmzOlMyKM7:TR?= M1vROHNCVkeHUh?=
SCC-15 M{XZSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTFwOUO4NVkh|ryP NEi1UJhUSU6JRWK=
HL-60 M4\OcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\kOGNMUUN3ME2xMlk{QTB{IN88US=> NUPRN2V5W0GQR1XS
human HOP-92 M3XVeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nPNWlEPTB;MT65OFA3PSEQvF2= NHvtbWJUSU6JRWK=
SW626 M2LCTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTpT5FrUUN3ME2xMlk1QDl7IN88US=> NV7aTHMyW0GQR1XS
HEC-1 M4LiO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTQdJpoUUN3ME2xMlk2OzZizszN NIXFVXJUSU6JRWK=
LB2241-RCC M2GyXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TBNWlEPTB;MT65PFI{OSEQvF2= MXrTRW5ITVJ?
Ramos-2G6-4C10 NEmyV5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzFN4hKSzVyPUGuPVk1QTNizszN M4P2XnNCVkeHUh?=
A101D Mmq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXuxdoJmUUN3ME2yMlIxOzB|IN88US=> NGjmd|dUSU6JRWK=
NCI-H446 NYG1RXViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnweHI3UUN3ME2yMlA1PTl7IN88US=> MXLTRW5ITVJ?
SBC-5 M2fWTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Lt[WlEPTB;Mj6wOlE1PyEQvF2= NUHSNpJ4W0GQR1XS
HOS M1rXNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPrTWM2OD1{LkC3OlU{KM7:TR?= MmPCV2FPT0WU
K5 M1\UVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofiTWM2OD1{LkC3PFEyKM7:TR?= MnfHV2FPT0WU
HLE MkTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLiNIR1UUN3ME2yMlA5PTJ7IN88US=> M3uzfXNCVkeHUh?=
HSC-2 NUT2[3ZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXkXYRXUUN3ME2yMlEzQDl6IN88US=> MX;TRW5ITVJ?
LCLC-97TM1 NYnKeHlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfqOohKSzVyPUKuNVQ2QDNizszN NEPDWlZUSU6JRWK=
DMS-273 Mk\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jKOmlEPTB;Mj6xOFg{PyEQvF2= Ml;PV2FPT0WU
TE-8 M3HCUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojUTWM2OD1{LkG1O|Y2KM7:TR?= MX;TRW5ITVJ?
DSH1 NEnye45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmD4TWM2OD1{LkG2N|k5KM7:TR?= MVTTRW5ITVJ?
CAL-51 NHjvV41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHJc3gyUUN3ME2yMlE3Pjl7IN88US=> MkT3V2FPT0WU
IST-SL1 MlTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVi1TIJJUUN3ME2yMlE3QDR2IN88US=> NXLMd5dEW0GQR1XS
GCT NEHPVVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTJwMUe3O{DPxE1? MXrTRW5ITVJ?
SW948 NX;jNWZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDBTWM2OD1{LkG4OFU3KM7:TR?= NG\jRmlUSU6JRWK=
NOMO-1 Mn21S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTJwMUmzNVch|ryP MnjsV2FPT0WU
C8166 MoO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTJwMkGzN|Qh|ryP M3LObHNCVkeHUh?=
OC-314 NX;VPWdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfzbpBoUUN3ME2yMlI{OjV7IN88US=> NH\odHFUSU6JRWK=
CAL-39 NFjYW45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkKzTWM2OD1{LkKzOlI3KM7:TR?= M1exeHNCVkeHUh?=
MDA-MB-453 MmXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojKTWM2OD1{LkK0Nlc2KM7:TR?= M2fDV3NCVkeHUh?=
A673 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVftUpBOUUN3ME2yMlI2QDZ{IN88US=> M4Gy[nNCVkeHUh?=
HTC-C3 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4n1O2lEPTB;Mj6yOlg2KM7:TR?= M3y4XnNCVkeHUh?=
NCI-H1666 NGHzNWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTJwMkixNVEh|ryP NUjJb4FDW0GQR1XS
PSN1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjXTWM2OD1{LkK4PVE{KM7:TR?= M1T1fnNCVkeHUh?=
GI-1 NHP1clRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M36we2lEPTB;Mj6zNFU1OyEQvF2= MnfHV2FPT0WU
HuH-7 MkHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTJwM{C2N|ch|ryP NXvISlVGW0GQR1XS
JAR M2XVc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXW1O3gxUUN3ME2yMlMyQTh5IN88US=> MWHTRW5ITVJ?
5637 MlziS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTJwM{KxNlkh|ryP NGDGcopUSU6JRWK=
GB-1 NEDCfYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3uybmlEPTB;Mj6zNlM{PSEQvF2= NVLhXJhiW0GQR1XS
KP-N-YS Mkf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLiTWM2OD1{LkOyOlE2KM7:TR?= NITrUXdUSU6JRWK=
OAW-42 NUOzZoJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\pTWM2OD1{LkOzOFE3KM7:TR?= MW\TRW5ITVJ?
8-MG-BA NGnlVFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTiTWM2OD1{LkOzPVA3KM7:TR?= MV3TRW5ITVJ?
RH-18 M4T5RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTJwM{WwNlIh|ryP M3[4OnNCVkeHUh?=
NCI-H1155 MmT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTJwM{[3NlUh|ryP M4n2d3NCVkeHUh?=
NB17 MmjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFL5cWxKSzVyPUKuN|gzPDNizszN MmrzV2FPT0WU
NCI-H1437 M4jlNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjLbYlSUUN3ME2yMlQyQDd|IN88US=> NWHBdWZlW0GQR1XS
SN12C M2\NbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LmNmlEPTB;Mj60N|IyPCEQvF2= NICzVY5USU6JRWK=
HSC-3 MnjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTJwNES1NFkh|ryP NHTO[HhUSU6JRWK=
GAMG NWXzZYM3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfvO2FKSzVyPUKuOFQ2PjFizszN NG\0U4tUSU6JRWK=
HT-1080 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUSxcFAzUUN3ME2yMlQ1QDZ2IN88US=> NUfGe2V7W0GQR1XS
A549 NUD5dZduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTsRZVPUUN3ME2yMlQ1QDl|IN88US=> MlLjV2FPT0WU
KNS-62 M2LrWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTJwNEWwOlEh|ryP M1PWOXNCVkeHUh?=
YKG-1 NHLvS5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjFTVViUUN3ME2yMlQ2PDN5IN88US=> M2LWZnNCVkeHUh?=
LU-134-A NW\xOnZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfkUWVKSzVyPUKuOFcxODhizszN NXvFdGduW0GQR1XS
FADU MkS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTJwNEexOlIh|ryP MVrTRW5ITVJ?
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HT-3 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTJwNEm1N|Uh|ryP MoG1V2FPT0WU
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BB65-RCC M3;SPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDtcJlmUUN3ME2zMlA{OzF2IN88US=> NEDXXVBUSU6JRWK=
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GT3TKB M3riemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3n5dGlEPTB;Mz6xNVI5OyEQvF2= NIL3VYRUSU6JRWK=
TK10 NHTmfnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLzTWM2OD1|LkGzO|I1KM7:TR?= M2jZd3NCVkeHUh?=
T-24 NVj4NVh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3f6UWlEPTB;Mz6xOVA4KM7:TR?= NHfTUYtUSU6JRWK=
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T47D NH\OfGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnmdZZ2UUN3ME2zMlI{PjJ5IN88US=> MW\TRW5ITVJ?
NCI-H1651 NEftd2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTNwMkS2OFQh|ryP NFz4WZRUSU6JRWK=
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HT-29 M3nR[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojTTWM2OD1|LkK2OlE1KM7:TR?= NFy4N|RUSU6JRWK=
GI-ME-N MlH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo[0TWM2OD1|LkK5OVEyKM7:TR?= NHKxZ5NUSU6JRWK=
SW756 M{LoXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTNwMkm2Nlkh|ryP NH7OdpJUSU6JRWK=
RKO Mom1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfaT3ZKSzVyPUOuN|A4PTdizszN M{DLNXNCVkeHUh?=
NCI-H1563 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7mTWM2OD1|LkOzNFE5KM7:TR?= NXXzNpBJW0GQR1XS
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L-428 MoPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PONmlEPTB;Mz60NFA1PSEQvF2= MUnTRW5ITVJ?
NCI-H2122 M1PuSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjLTWM2OD1|LkSxN|EzKM7:TR?= MkL6V2FPT0WU
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639-V MmPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLFTWM2OD1|LkS2NFU4KM7:TR?= MkHTV2FPT0WU
SW1116 M2XD[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTNwNE[yOlkh|ryP NX;GOog2W0GQR1XS
DMS-114 MkLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvBTWM2OD1|LkS3NFY3KM7:TR?= NHW4V3BUSU6JRWK=
MZ2-MEL M4S1SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nmSmlEPTB;Mz60O|Y5OSEQvF2= NYPiPFN1W0GQR1XS
COLO-829 MoL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTNwNUCwO|Mh|ryP M2r5RnNCVkeHUh?=
J82 NX\uZ4V4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HmNWlEPTB;Mz61NFU4KM7:TR?= NEnhSm5USU6JRWK=
EW-13 NEX2dVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTNwNUK1NUDPxE1? NX;wSZBPW0GQR1XS
RXF393 NHLGVllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLsS2dKSzVyPUOuOVMzQTRizszN MmfPV2FPT0WU
CAL-62 NWDmbWZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTNwNUS1NVQh|ryP MYjTRW5ITVJ?
OCUB-M MkC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn36TWM2OD1|LkW0OlY2KM7:TR?= MmSyV2FPT0WU
BT-474 NH\qVoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{[yZ2lEPTB;Mz62N|MyKM7:TR?= M3Pib3NCVkeHUh?=
KYSE-180 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTNwNkOzO|Ih|ryP M4jqZ3NCVkeHUh?=
NCI-H650 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoewTWM2OD1|Lk[0Nlg4KM7:TR?= NF3PeGtUSU6JRWK=
Detroit562 M{XiTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;TTWlEPTB;Mz62OVAzOiEQvF2= MVjTRW5ITVJ?
SW48 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TNWGlEPTB;Mz62OVY2PyEQvF2= NGHMbG5USU6JRWK=
KYSE-450 NXrkVpo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\P[I5KSzVyPUOuOlg2QDJizszN NGK3ZWZUSU6JRWK=
KYSE-510 NXLCXXVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnv0TWM2OD1|LkeyNVgyKM7:TR?= M1;CXXNCVkeHUh?=
GP5d MnLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorSTWM2OD1|LkeyPVUh|ryP NYDZSmQ3W0GQR1XS
RPMI-7951 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLTTJpQUUN3ME2zMlc1PzJ|IN88US=> MVPTRW5ITVJ?
Becker M{fUdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXj3c5d[UUN3ME2zMlc2ODF{IN88US=> MkXVV2FPT0WU
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G-401 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HIUmlEPTB;Mz63PVA5PSEQvF2= M4K1XXNCVkeHUh?=
PANC-08-13 MorvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\TU2lEPTB;Mz63PVYxOiEQvF2= MlS2V2FPT0WU
SW982 MoO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPZOVNKSzVyPUOuPFA2PTFizszN MnLwV2FPT0WU
D-263MG NHPMSVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\HXnVZUUN3ME2zMlgzODVzIN88US=> M3nVXHNCVkeHUh?=
KM-H2 MmHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjyNI1KSzVyPUOuPFI3OjRizszN M{DNWnNCVkeHUh?=
SK-MEL-3 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3G3UGlEPTB;Mz64Nlg1OSEQvF2= NYnSZoVZW0GQR1XS
NCI-H1581 M{WxeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrQR|hKSzVyPUOuPFQ1QDhizszN NXXqVVZsW0GQR1XS
LS-123 M4Hk[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPKTWM2OD1|Lki3PVA6KM7:TR?= M2PQdXNCVkeHUh?=
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MEL-JUSO M2fNeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fq[mlEPTB;Mz64PVE2OyEQvF2= NGfCbmZUSU6JRWK=
HCE-4 MlvDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHxeXNyUUN3ME2zMlkyPjZ|IN88US=> NVrtfFNjW0GQR1XS
TE-10 NWPCfop1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITtfm1KSzVyPUOuPVIxOSEQvF2= MUDTRW5ITVJ?
OVCAR-4 NH7nOHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfWTWM2OD1|LkmyPFg6KM7:TR?= MYfTRW5ITVJ?
ETK-1 NWnqSHVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rvT2lEPTB;Mz65OFY{PSEQvF2= NHTVWmtUSU6JRWK=
A2780 MkSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTRwMEW5OlYh|ryP MVvTRW5ITVJ?
LU-65 M4i2dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vNbWlEPTB;ND6wO|Y{OyEQvF2= MlLaV2FPT0WU
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COR-L105 MnmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHO4WHVKSzVyPUSuNVMxPTFizszN NFv1e45USU6JRWK=
CAL-12T NHfVemZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXyWWVCUUN3ME20MlE{OTB|IN88US=> NU\tNJo{W0GQR1XS
SCH NFH4NIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVK5b5Y2UUN3ME20MlE2PzR|IN88US=> NHHucmJUSU6JRWK=
CW-2 MlTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTRwMUmwNFEh|ryP NVXOVo1QW0GQR1XS
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CAL-54 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;XTWM2OD12LkKyN|gyKM7:TR?= Ml7tV2FPT0WU
CAL-33 M4K2TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWn2e3dFUUN3ME20MlI{ODZ2IN88US=> NWHBPVhpW0GQR1XS
SNU-C2B NHvofY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYeycFBUUUN3ME20MlI1PzZ7IN88US=> MojhV2FPT0WU
NUGC-3 M1nBbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXraenU3UUN3ME20MlI2PTB3IN88US=> NH7PSIFUSU6JRWK=
DOK M4HQd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHBTWM2OD12LkK2OVk{KM7:TR?= NV\tS|M2W0GQR1XS
MMAC-SF NX\ZNZJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7YTWM2OD12LkK2PFU6KM7:TR?= NXrDcVdNW0GQR1XS
KYSE-70 MoDFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGCwTIxKSzVyPUSuNlk{PCEQvF2= Mmr0V2FPT0WU
A204 M1zRSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfqNlBKSzVyPUSuN|U5ODNizszN NEjMPYpUSU6JRWK=
SCC-25 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnqwTWM2OD12LkO1PFE6KM7:TR?= M1LuSXNCVkeHUh?=
EPLC-272H M1yxeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\tUGlEPTB;ND6zPFk2KM7:TR?= MYLTRW5ITVJ?
CAL-120 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHniTJFKSzVyPUSuN|g6QTJizszN MYrTRW5ITVJ?
LS-513 NIn6OmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfQV5FKSzVyPUSuOFIyQThizszN NGD3So5USU6JRWK=
CAPAN-1 M3PQTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnKTWM2OD12LkSyN|gzKM7:TR?= NGXkT4xUSU6JRWK=
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BEN NETF[2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITvSnFKSzVyPUmuPFIyPTlizszN M{XWcHNCVkeHUh?=
CP50-MEL-B NYfnNm94T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGmyPW5KSzVyPUmuPVI1OzJizszN NWr2eZY4W0GQR1XS
SK-MEL-28 NWLBSlZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7KWllpUUN3ME2xNE4xOTl|IN88US=> M1r5WXNCVkeHUh?=
NCI-H2452 MoK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfuTWM2OD1zMD6xOkDPxE1? NHrvVpBUSU6JRWK=
NCI-H1395 NFzPTlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVL6fVhGUUN3ME2xNE4yPzhizszN M1PBWnNCVkeHUh?=
NCI-H2052 NYO4VYlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPzTVZyUUN3ME2xNE4yQDh{IN88US=> MnHDV2FPT0WU
A375 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXjNmRJUUN3ME2xNE4zPDV{IN88US=> NGTke5ZUSU6JRWK=
HCC38 NVLCPGk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTFyLkOyNkDPxE1? NYD5PGhGW0GQR1XS
LK-2 NH\lN3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDMXpp5UUN3ME2xNE41OjB6IN88US=> M2LLZnNCVkeHUh?=
SF126 NXnGfnJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTFyLkS3Nlch|ryP MXTTRW5ITVJ?
SK-MEL-1 NWnIVWlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofiTWM2OD1zMD63PFM5KM7:TR?= M1\xV3NCVkeHUh?=
ACN M1X1c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHTVpd6UUN3ME2xNE45Pjd7IN88US=> NYf5TWhkW0GQR1XS
BB30-HNC MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvkTWM2OD1zMD64O|EyKM7:TR?= MoSwV2FPT0WU
NCI-H747 NHfkNo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHVZohHUUN3ME2xNE45PzR4IN88US=> NVr0SI1MW0GQR1XS
KYSE-150 NVf6N5V2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfDWoNKSzVyPUGxMlA{QDdizszN M2CwbHNCVkeHUh?=
D-247MG M{T6UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTFzLkGwNFkh|ryP M{jFSnNCVkeHUh?=
BxPC-3 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGC3WFlKSzVyPUGxMlM4PDdizszN NXPN[4F6W0GQR1XS
SK-MEL-30 M4Hodmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojuTWM2OD1zMT60NFc6KM7:TR?= MoDSV2FPT0WU
CAS-1 M3vvXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LtU2lEPTB;MUGuOFExQSEQvF2= NXW0bnYzW0GQR1XS
no-10 Mn;oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\PdHpKSzVyPUGyMlEzOTdizszN NFHyOYtUSU6JRWK=
NCI-H2405 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HXXmlEPTB;MUKuNlA{PiEQvF2= NHe1b21USU6JRWK=
KGN NGjFdYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrXe5VzUUN3ME2xNk4zQTBzIN88US=> NWT1eZZiW0GQR1XS
BB49-HNC MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvkTWM2OD1zMj6zPVU3KM7:TR?= M3jPbXNCVkeHUh?=
NCI-H1693 NUXYUFBsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\heVZtUUN3ME2xNk42QDF4IN88US=> NVz3fllMW0GQR1XS
RO82-W-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVL4V41yUUN3ME2xN{4xPjR7IN88US=> NXfjTGtyW0GQR1XS
CAL-85-1 M4\mU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoP5TWM2OD1zMz60N|k6KM7:TR?= NX7XSmtyW0GQR1XS
H-EMC-SS MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TOVWlEPTB;MUOuPVExPCEQvF2= MUHTRW5ITVJ?
SW1783 MojkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml[wTWM2OD1zND6yN|kyKM7:TR?= MUTTRW5ITVJ?
LB771-HNC MoiwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPLS2twUUN3ME2xOE41OTlizszN MUDTRW5ITVJ?
HCC70 NH\aZ3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTF2LkSyN|Mh|ryP MnTrV2FPT0WU
KNS-81-FD MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXHNINKSzVyPUG0MlcxPDVizszN M1e5V3NCVkeHUh?=
KYSE-520 MmTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XGNGlEPTB;MUSuPVI4KM7:TR?= MXTTRW5ITVJ?
TGBC24TKB NILVVo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHOVIVvUUN3ME2xOE46PTN7IN88US=> M1nwU3NCVkeHUh?=
SNB75 NEfHcZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTF3LkC3Nlkh|ryP NEPZeJNUSU6JRWK=
SW872 NHjHPY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{mxS2lEPTB;MUWuNlIyQCEQvF2= MmTHV2FPT0WU
U031 M3LnSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTF3LkiwNlgh|ryP NWH2XGkxW0GQR1XS
ChaGo-K-1 MnP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTF3LkizOVkh|ryP MknBV2FPT0WU
NCI-H441 NFnFSpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37mPWlEPTB;MU[uNFA{QSEQvF2= MXXTRW5ITVJ?
TE-12 Mm\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHz5OYVKSzVyPUG2MlE5PzNizszN NI[1TZRUSU6JRWK=
NCI-H1755 MlrPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXITpg3UUN3ME2xOk42PzNizszN NGrTXolUSU6JRWK=
KNS-42 NXfSXJNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTF4Lk[1PFkh|ryP MoTCV2FPT0WU
SK-PN-DW M17JXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7UclRKSzVyPUG3MlQzODFizszN NY[0WJBOW0GQR1XS
NCI-H226 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1q4[2lEPTB;MUeuPVM1PSEQvF2= MoTuV2FPT0WU
K-562 NYrkPIM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH6zbnlKSzVyPUG4MlY{OTdizszN M4XBeHNCVkeHUh?=
A388 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWSwPXkzUUN3ME2xPU4xOzB|IN88US=> M3L0cnNCVkeHUh?=
ZR-75-30 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHf0VVBKSzVyPUG5MlA6PjhizszN MUHTRW5ITVJ?
LU-135 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7W[WtKSzVyPUG5MlI3OzZizszN Ml63V2FPT0WU
NCI-H2029 M1TpVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jYd2lEPTB;MUmuOlAzOSEQvF2= MWDTRW5ITVJ?
HT-1197 NEm2SW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfmWHRZUUN3ME2xPU46OjJ5IN88US=> NXnFOZZpW0GQR1XS
IGR-1 NU\kOot5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPU[m9KSzVyPUKwMlMyOTdizszN M2fPcXNCVkeHUh?=
U-87-MG NEi0NWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTsdJNRUUN3ME2yNE43PDF|IN88US=> Mm\3V2FPT0WU
NCI-H1304 NELpWVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HSdmlEPTB;MkCuO|UxOSEQvF2= Mnn3V2FPT0WU
RCC10RGB NXThcYxTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTJzLkK4Nlkh|ryP NFfCWHJUSU6JRWK=
NCI-H520 M1HS[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTJ{Lke2NVEh|ryP NXTnR243W0GQR1XS
SK-LU-1 Ml3PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTJ|LkC3NVgh|ryP M3XPeXNCVkeHUh?=
UACC-893 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XqXWlEPTB;MkOuNVA{QCEQvF2= NX\Sdoo6W0GQR1XS
NCI-H2347 NEPzdW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTJ|LkK2O|Qh|ryP NEHaUINUSU6JRWK=
U-118-MG MmW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTEfVh6UUN3ME2yN{44OjF5IN88US=> NWf3PGVkW0GQR1XS
NCI-H596 M4Dm[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\2SGlEPTB;MkOuPVA2PSEQvF2= M4XpOHNCVkeHUh?=
MZ1-PC NFnKTVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nlSWlEPTB;MkSuOlc2QSEQvF2= MlPHV2FPT0WU
SW1417 M1LodWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjUelJKSzVyPUK1MlI1QThizszN M3PqPHNCVkeHUh?=
NCI-H82 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlruTWM2OD1{Nj60Nlg5KM7:TR?= NXfvRpNsW0GQR1XS
COLO-678 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Hw[GlEPTB;MkeuOFkyQSEQvF2= NH:zbGVUSU6JRWK=
KURAMOCHI NI\jXI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDKUZVSUUN3ME2yPE4yOjZizszN MkezV2FPT0WU
NCI-H1650 NUjuVVNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjFTWM2OD1|MD6xPVI1KM7:TR?= NGTmNJRUSU6JRWK=
HCC1954 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\3SmlEPTB;M{GuN|Y3PiEQvF2= NUHabVNWW0GQR1XS
GAK M{TlcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1G4ZmlEPTB;M{KuNlYyPiEQvF2= MVfTRW5ITVJ?
YAPC M33oVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFz4OZhKSzVyPUOzMlc3PDhizszN M3HKNHNCVkeHUh?=
NCI-H2228 M1jpPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmT0TWM2OD1|ND6zOlA2KM7:TR?= MVXTRW5ITVJ?
VMRC-RCZ M3PYSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\JcYR6UUN3ME2zOk4{ODJ{IN88US=> NWHYUpBiW0GQR1XS
NMC-G1 M2\Wfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTN5LkC1Nlkh|ryP MnXGV2FPT0WU
D-336MG NUW4fW15T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX75PZJmUUN3ME20NU45PDR{IN88US=> M1q0W3NCVkeHUh?=
UACC-62 NWLvelZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTSTWM2OD12Mj61OVA2KM7:TR?= NYT0bmpmW0GQR1XS
C-33-A NGjPeIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{n0eGlEPTB;NEWuN|I2PiEQvF2= M2DD[3NCVkeHUh?=
HCC1937 NI\5dYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPYTWM2OD12Nz6xPVU5KM7:TR?= NH3yVWpUSU6JRWK=
HDLM-2 NWT1SXNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrme5NqUUN3ME20O{4zOjh5IN88US=> NV;oTnNLW0GQR1XS
NCI-H727 Mn:wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2WwN2lEPTB;NEeuNlQ2OSEQvF2= MmD6V2FPT0WU
NY M3zaeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLKTWM2OD12OT6zPVA5KM7:TR?= MWTTRW5ITVJ?
NCI-H2291 NUjEW4psT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTR7LkizNFEh|ryP M1L3UnNCVkeHUh?=

多くの細胞株試験データを見る場合、クリックしてください

体内試験 Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

お薦めの試験操作(参考用のみ)

キナーゼ試験:

[1]

+ 展開

Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
細胞試験:

[2]

+ 展開
  • 細胞株: LNCaP, PC-3, and TSU-Pr1
  • 濃度: Dissolved in DMSO, final concentrations ~7.5 μM
  • 反応時間: 1, 2, 3 and 4 days
  • 実験の流れ:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (参考用のみ)
動物試験:

[2]

+ 展開
  • 動物モデル: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • 製剤: Dissolved in DMSO
  • 投薬量: ~100 mg/kg/day
  • 投与方法: Injection i.p.
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
体内 左から右までの手順で、溶剤を製品に加えることです:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
いい結果が出るために、混じった後、直ちに使うと推めます。
5mg/mL

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 264.3
化学式

C14H20N2O3

CAS No. 149647-78-9
保管
in solvent
別名 SAHA, MK0683, suberoylanilide hydroxamic acid

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01059552 Active, not recruiting Locally Advanced Non-small Cell Lung Cancer Fox Chase Cancer Center|National Comprehensive Cancer Network December 6, 2009 Phase 1
NCT02108002 Enrolling by invitation Von Hippel-Lindau Disease National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) March 5, 2014 Phase 1
NCT03022565 Not yet recruiting Uveal Melanoma Nicolas Acquavella|University of Miami Sylvester Comprehensive Cancer Center|University of Miami April 2017 --
NCT02943642 Not yet recruiting Mycosis Fungoides Angimmune LLC|City of Hope National Medical Center|Columbia University|Dana-Farber Cancer Institute|Feinberg School of Medicine, Northwestern University|H. Lee Moffitt Cancer Center and Research Institute|Ohio State University Comprehensive Cancer Center|Rush University Medical Center|Scott and White Hospital & Clinic|Yale University|Stanford University|Thomas Jefferson University|University of Arkansas|University of Colorado Denver School of Medicine Barbara Davis Center|University of Texas Southwestern Medical Center|University of Washington|Vanderbilt University School of Medicine|Washington University School of Medicine January 2017 Phase 2
NCT02836548 Recruiting Melanoma|Skin Neoplasms The Netherlands Cancer Institute June 2016 Phase 1|Phase 2
NCT02589145 Recruiting Lymphoma M.D. Anderson Cancer Center|Celgene Corporation June 2016 Phase 1|Phase 2

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

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Tags: Vorinostat (SAHA, MK0683)を買う | Vorinostat (SAHA, MK0683) ic50 | Vorinostat (SAHA, MK0683)供給者 | Vorinostat (SAHA, MK0683)を購入する | Vorinostat (SAHA, MK0683)費用 | Vorinostat (SAHA, MK0683)生産者 | オーダーVorinostat (SAHA, MK0683) | Vorinostat (SAHA, MK0683)化学構造 | Vorinostat (SAHA, MK0683)分子量 | Vorinostat (SAHA, MK0683)代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID