CFTR

シグナル伝達経路

研究分野

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S6003 Ataluren (PTC124) <1 mg/mL 57 mg/mL <1 mg/mL
S7139 CFTRinh-172 <1 mg/mL 82 mg/mL <1 mg/mL
S7329 IOWH032 <1 mg/mL 100 mg/mL <1 mg/mL
S8094 GlyH-101 <1 mg/mL 98 mg/mL <1 mg/mL
S1144 Ivacaftor (VX-770) <1 mg/mL 78 mg/mL <1 mg/mL
S8698 GLPG1837 <1 mg/mL 69 mg/mL 5 mg/mL
S6003 Ataluren (PTC124) <1 mg/mL 57 mg/mL <1 mg/mL
S7139 CFTRinh-172 <1 mg/mL 82 mg/mL <1 mg/mL
S7329 IOWH032 <1 mg/mL 100 mg/mL <1 mg/mL
S8094 GlyH-101 <1 mg/mL 98 mg/mL <1 mg/mL
製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S6003

Ataluren (PTC124)

Ataluren (PTC124) selectively induces ribosomal read-through of premature but not normal termination codons, with EC50 of 0.1 μM in HEK293 cells, may provide treatment for genetic disorders caused by nonsense mutations (e.g. CF caused by CFTR nonsense mutation). Phase 3.

S7139

CFTRinh-172

CFTRinh-172 is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters.

S7329

IOWH032

IOWH032 is a synthetic CFTR inhibitor with IC50 of 1.01 μM in CHO-CFTR cell based assays. Phase 2.

S8094

GlyH-101

GlyH-101 is a selective and reversible CFTR inhibitor with Ki of 4.3 μM.

S1144

Ivacaftor (VX-770)

Ivacaftor (VX-770) is a selective potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM in fisher rat thyroid cells, respectively.

S8698

GLPG1837

GLPG1837 is a novel CFTR potentiator with an EC50 value of 3 nM for F508del, showing enhanced efficacy on CFTR mutants harboring class III mutations compared to Ivacaftor.

S6003

Ataluren (PTC124)

Ataluren (PTC124) selectively induces ribosomal read-through of premature but not normal termination codons, with EC50 of 0.1 μM in HEK293 cells, may provide treatment for genetic disorders caused by nonsense mutations (e.g. CF caused by CFTR nonsense mutation). Phase 3.

S7139

CFTRinh-172

CFTRinh-172 is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters.

S7329

IOWH032

IOWH032 is a synthetic CFTR inhibitor with IC50 of 1.01 μM in CHO-CFTR cell based assays. Phase 2.

S8094

GlyH-101

GlyH-101 is a selective and reversible CFTR inhibitor with Ki of 4.3 μM.