DPP

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S4002 Sitagliptin phosphate monohydrate 41 mg/mL 100 mg/mL <1 mg/mL
S3033 Vildagliptin (LAF-237) 60 mg/mL 60 mg/mL 60 mg/mL
S1540 Saxagliptin (BMS-477118) 63 mg/mL 63 mg/mL '''24 mg/mL
S2868 Alogliptin (SYR-322) benzoate 2 mg/mL 68 mg/mL <1 mg/mL
S5365 Alogliptin 18 mg/mL 67 mg/mL 67 mg/mL
P1134 diprotin A 68 mg/mL 68 mg/mL 68 mg/mL
E0122 Gemigliptin 12 mg/mL 98 mg/mL ''7 mg/mL
S8565 Omarigliptin (MK-3102) <1 mg/mL 79 mg/mL <1 mg/mL
S9631 Puromycin aminonucleoside 30 mg/mL 59 mg/mL '''''<1 mg/mL
S5909 Anagliptin 20 mg/mL 77 mg/mL 77 mg/mL
S7513 Trelagliptin <1 mg/mL 71 mg/mL 3 mg/mL
S8455 Talabostat (PT-100) 62 mg/mL 62 mg/mL 62 mg/mL
S4697 Saxagliptin hydrate 1 mg/mL 66 mg/mL 66 mg/mL
S5063 Trelagliptin succinate 95 mg/mL 95 mg/mL 5 mg/mL
S5079 Sitagliptin -1 mg/mL 81 mg/mL -1 mg/mL

DPP製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S4002

Sitagliptin phosphate monohydrate

Sitagliptin phosphate monohydrate (MK-0431) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.

S3033

Vildagliptin (LAF-237)

Vildagliptin (LAF-237) inhibits DPP−4 with IC50 of 2.3 nM.

S1540

Saxagliptin (BMS-477118)

Saxagliptin (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.

S2868

Alogliptin (SYR-322) benzoate

Alogliptin (SYR-322) benzoate is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.

S5365

Alogliptin

Alogliptin is a potent, selective inhibitor of the serine protease dipeptidyl peptidase IV (DPP-4)with IC50 values of 2.63 nM and exhibits greater than 10,000 fold selectivity over the closely related serine proteases DPP-8 and DPP-9.

P1134

diprotin A

Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).

E0122

Gemigliptin

Gemigliptin (Zemiglo, LC15-0444) is a potent, selective and long-acting dipeptidyl peptidase 4 (DPP 4) inhibitor with a Ki of 7.25 nM. Gemigliptin shows at least >23,000-fold selectivity for DPP-4 over various proteases and peptidases, including DPP-8, DPP-9, and fibroblast activation protein (FAP)-α.

S8565

Omarigliptin (MK-3102)

Omarigliptin (MK-3102) is a competitive, reversible inhibitor of DPP-4 (IC50 = 1.6 nM, Ki = 0.8 nM). It is highly selective over all proteases tested (IC50 > 67 μM), including QPP, FAP, PEP, DPP8, and DPP9 and has weak ion channel activity (IC50 > 30 μM at IKr, Caγ1.2, and Naγ1.5).

S9631

Puromycin aminonucleoside

Puromycin aminonucleoside (NSC 3056, PAN, Stylomycin aminonucleoside, ARDMA, SAN), the aminonucleoside portion of the antibiotic puromycin, is a reversible inhibitor of dipeptidyl-peptidase II and cytosol alanyl aminopeptidase that induces apoptosis in mesangial cells (MCs) accompanied by declined cell viability and enhanced inflammatory response.

S5909

Anagliptin

Anagliptin is an orally active and highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor and exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.

S7513

Trelagliptin

Trelagliptin (SYR-472), a potent, orally active and highly selective DPP-4 inhibitor with an IC50 of 4 nM, improves glycemic control in vivo and can be used for the study of type 2 diabetes mellitus (T2DM).

S8455

Talabostat (PT-100)

Talabostat (Val-boroPro, PT-100) is a dipeptidyl peptidase inhibitor with IC50 values of <4 nM, 4 nM, 11 nM, 310 nM, 560 nM and 390 nM for DPP-IV, DPP8, DPP9, QPP, FAP and PEP respectively. It has antineoplastic and hematopoiesis- stimulating activities.

S4697

Saxagliptin hydrate

Saxagliptin H2O (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.

S5063

Trelagliptin succinate

Trelagliptin succinate (SYR472) is a dipeptidyl peptidase IV (DPP-4) inhibitor which is used as a new long-acting drug for once-weekly treatment of type 2 diabetes mellitus (DM).

S5079

Sitagliptin

Sitagliptin (MK-0431) is an oral and highly selective DPP-4 inhibitor with an IC50 of 18 nM. It is used for the treatment of type 2 diabetes.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S4002

Sitagliptin phosphate monohydrate

Sitagliptin phosphate monohydrate (MK-0431) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.

S3033

Vildagliptin (LAF-237)

Vildagliptin (LAF-237) inhibits DPP−4 with IC50 of 2.3 nM.

S1540

Saxagliptin (BMS-477118)

Saxagliptin (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.

S2868

Alogliptin (SYR-322) benzoate

Alogliptin (SYR-322) benzoate is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.

S5365

Alogliptin

Alogliptin is a potent, selective inhibitor of the serine protease dipeptidyl peptidase IV (DPP-4)with IC50 values of 2.63 nM and exhibits greater than 10,000 fold selectivity over the closely related serine proteases DPP-8 and DPP-9.

P1134

diprotin A

Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).

E0122

Gemigliptin

Gemigliptin (Zemiglo, LC15-0444) is a potent, selective and long-acting dipeptidyl peptidase 4 (DPP 4) inhibitor with a Ki of 7.25 nM. Gemigliptin shows at least >23,000-fold selectivity for DPP-4 over various proteases and peptidases, including DPP-8, DPP-9, and fibroblast activation protein (FAP)-α.

S8565

Omarigliptin (MK-3102)

Omarigliptin (MK-3102) is a competitive, reversible inhibitor of DPP-4 (IC50 = 1.6 nM, Ki = 0.8 nM). It is highly selective over all proteases tested (IC50 > 67 μM), including QPP, FAP, PEP, DPP8, and DPP9 and has weak ion channel activity (IC50 > 30 μM at IKr, Caγ1.2, and Naγ1.5).

S9631

Puromycin aminonucleoside

Puromycin aminonucleoside (NSC 3056, PAN, Stylomycin aminonucleoside, ARDMA, SAN), the aminonucleoside portion of the antibiotic puromycin, is a reversible inhibitor of dipeptidyl-peptidase II and cytosol alanyl aminopeptidase that induces apoptosis in mesangial cells (MCs) accompanied by declined cell viability and enhanced inflammatory response.

S5909

Anagliptin

Anagliptin is an orally active and highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor and exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.

S7513

Trelagliptin

Trelagliptin (SYR-472), a potent, orally active and highly selective DPP-4 inhibitor with an IC50 of 4 nM, improves glycemic control in vivo and can be used for the study of type 2 diabetes mellitus (T2DM).

S8455

Talabostat (PT-100)

Talabostat (Val-boroPro, PT-100) is a dipeptidyl peptidase inhibitor with IC50 values of <4 nM, 4 nM, 11 nM, 310 nM, 560 nM and 390 nM for DPP-IV, DPP8, DPP9, QPP, FAP and PEP respectively. It has antineoplastic and hematopoiesis- stimulating activities.

S4697

Saxagliptin hydrate

Saxagliptin H2O (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.

S5063

Trelagliptin succinate

Trelagliptin succinate (SYR472) is a dipeptidyl peptidase IV (DPP-4) inhibitor which is used as a new long-acting drug for once-weekly treatment of type 2 diabetes mellitus (DM).

S5079

Sitagliptin

Sitagliptin (MK-0431) is an oral and highly selective DPP-4 inhibitor with an IC50 of 18 nM. It is used for the treatment of type 2 diabetes.

Tags: DPP inhibitor|DPP agonist|DPP activator|DPP inducer|DPP antagonist|DPP signaling pathway|DPP assay kit