Factor Xa
シグナル伝達経路
研究分野
阻害剤の選択性比較
| カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | アルコール | ||
| S3002 | Rivaroxaban (BAY 59-7939) | <1 mg/mL | 87 mg/mL | '<1 mg/mL |
| S1593 | Apixaban (BMS 562247-01) | <1 mg/mL | 18 mg/mL | '<1 mg/mL |
| S1346 | Heparin sodium | 100 mg/mL | <1 mg/mL | <1 mg/mL |
| S7280 | Edoxaban tosylate Monohydrate | <1 mg/mL | 100 mg/mL | <1 mg/mL |
| S3736 | Fondaparinux Sodium (Org 31540) | 100 mg/mL | 1 mg/mL | '''''<1 mg/mL |
| S4429 | Edoxaban | <1 mg/mL | 10 mg/mL | '<1 mg/mL |
| S5388 | Betrixaban | <1 mg/mL | 35 mg/mL | <1 mg/mL |
| S5389 | Betrixaban maleate | 1 mg/mL | 100 mg/mL | <1 mg/mL |
Factor Xa製品
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S3002 |
Rivaroxaban (BAY 59-7939)Rivaroxaban (BAY 59-7939) is a direct inhibitor of Factor Xa with Ki and IC50 of 0.4 nM and 0.7 nM in cell-free assays, respectively. It is selective for human factor Xa, for which it has >10 000-fold greater selectivity than for other biologically relevant serine proteases (IC50 >20 μM). |
a, BMDMs were pretreated with or without 10 μM FXa inhibitor rivaroxaban or 10 μM DPP4 inhibitor KR62436, followed by incubation for 4 h with rFX or rDPP4 alone or in combination. Mcp1 mRNA was then quantified. n = 4 technical replicates per group; mean ± s.e.m.; *P < 0.05 by one-way ANOVA.
|
|
| S1593 |
Apixaban (BMS 562247-01)Apixaban (BMS 562247-01) is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively. |
The peak fluorescence of each time course at the specified drug concentration are plotted as a function of concentration of apixaban. Dose-response curve was fitted to the Hill equation.
|
|
| S1346 |
Heparin sodiumHeparin sodium, a sulfated polysaccharide belonging to the family of glycosaminoglycans, has numerous important biological activities associated with its interaction with diverse proteins. Heparin is used as an anticoagulant primarily through its interaction with AT III by enhancing AT-IIImediated inhibition of blood coagulation factors, including thrombin and factor Xa. Heparin prevents the induction of autophagy. |
||
| S7280 |
Edoxaban tosylate MonohydrateEdoxaban (DU-176b) is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug. |
||
| S3736 |
Fondaparinux Sodium (Org 31540)Fondaparinux Sodium (Org 31540, Natural heparin pentasaccharide, Fondaparin, SR-90107A) is a synthetic glucopyranoside with antithrombotic activity. It selectively binds to antithrombin III, thereby potentiating the innate neutralization of activated factor X (Factor Xa) by antithrombin; a synthetic inhibitor of Factor Xa. |
||
| S4429新 |
EdoxabanEdoxaban (DU-176b, Savaysa), an antithrombotic agent, is a selective, potent and orally active inhibitor of factor Xa (FXa) with Ki of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. |
||
| S5388 |
BetrixabanBetrixaban is a new, long-acting, oral and selective Factor Xa inhibitor that decreases prothrombinase activity and thrombin generation. |
||
| S5389 |
Betrixaban maleateBetrixaban maleate is the maleate salt form of Betrixaban, which is a Factor Xa inhibitor that decreases prothrombinase activity and thrombin generation. |
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S3002 |
Rivaroxaban (BAY 59-7939)Rivaroxaban (BAY 59-7939) is a direct inhibitor of Factor Xa with Ki and IC50 of 0.4 nM and 0.7 nM in cell-free assays, respectively. It is selective for human factor Xa, for which it has >10 000-fold greater selectivity than for other biologically relevant serine proteases (IC50 >20 μM). |
a, BMDMs were pretreated with or without 10 μM FXa inhibitor rivaroxaban or 10 μM DPP4 inhibitor KR62436, followed by incubation for 4 h with rFX or rDPP4 alone or in combination. Mcp1 mRNA was then quantified. n = 4 technical replicates per group; mean ± s.e.m.; *P < 0.05 by one-way ANOVA.
|
|
| S1593 |
Apixaban (BMS 562247-01)Apixaban (BMS 562247-01) is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively. |
The peak fluorescence of each time course at the specified drug concentration are plotted as a function of concentration of apixaban. Dose-response curve was fitted to the Hill equation.
|
|
| S1346 |
Heparin sodiumHeparin sodium, a sulfated polysaccharide belonging to the family of glycosaminoglycans, has numerous important biological activities associated with its interaction with diverse proteins. Heparin is used as an anticoagulant primarily through its interaction with AT III by enhancing AT-IIImediated inhibition of blood coagulation factors, including thrombin and factor Xa. Heparin prevents the induction of autophagy. |
||
| S7280 |
Edoxaban tosylate MonohydrateEdoxaban (DU-176b) is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug. |
||
| S3736 |
Fondaparinux Sodium (Org 31540)Fondaparinux Sodium (Org 31540, Natural heparin pentasaccharide, Fondaparin, SR-90107A) is a synthetic glucopyranoside with antithrombotic activity. It selectively binds to antithrombin III, thereby potentiating the innate neutralization of activated factor X (Factor Xa) by antithrombin; a synthetic inhibitor of Factor Xa. |
||
| S4429新 |
EdoxabanEdoxaban (DU-176b, Savaysa), an antithrombotic agent, is a selective, potent and orally active inhibitor of factor Xa (FXa) with Ki of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. |
||
| S5388 |
BetrixabanBetrixaban is a new, long-acting, oral and selective Factor Xa inhibitor that decreases prothrombinase activity and thrombin generation. |
||
| S5389 |
Betrixaban maleateBetrixaban maleate is the maleate salt form of Betrixaban, which is a Factor Xa inhibitor that decreases prothrombinase activity and thrombin generation. |
