NADPH-oxidase

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S8639 Diphenyleneiodonium chloride (DPI) <1 mg/mL 13 mg/mL '<1 mg/mL
S6656 VAS2870 <1 mg/mL 36 mg/mL <1 mg/mL
S0777 APX-115 free base <1 mg/mL 56 mg/mL '''56 mg/mL
S9617 G6PDi-1 <1 mg/mL 57 mg/mL '''<1 mg/mL
S2425 Apocynin <1 mg/mL 33 mg/mL 33 mg/mL
S8974 GSK2795039 <1 mg/mL 90 mg/mL ''''20 mg/mL
S0178 GLX351322 <1 mg/mL 20 mg/mL '''4 mg/mL
S2348 Rotenone (Barbasco) <1 mg/mL 55 mg/mL 2 mg/mL
S7171 Setanaxib (GKT137831) <1 mg/mL 78 mg/mL '<1 mg/mL
S5304 2-Acetylphenothiazine (ML171) -1 mg/mL 48 mg/mL '-1 mg/mL

NADPH-oxidase製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S8639

Diphenyleneiodonium chloride (DPI)

Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS).

S6656

VAS2870

VAS2870 is a pan-NADPH oxidase (NOX) inhibitor.

S0777

APX-115 free base

APX-115 free base (Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney.

S9617

G6PDi-1

G6PDi-1 is an effective inhibitor of glucose-6-phosphate dehydrogenase (G6PD). G6PDi-1 depletes NADPH and decreases inflammatory cytokine production.

S2425

Apocynin

Apocynin (Acetovanillone) is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.

S8974

GSK2795039

GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. GSK2795039 inhibits reactive oxygen species (ROS) production, NADPH consumption and reduces apoptosis.

S0178

GLX351322

GLX351322 is a NADPH oxidase 4 (NOX4) inhibitor. GLX351322 inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 μM.

S2348

Rotenone (Barbasco)

Rotenone (Barbasco, Dactinol, Paraderil, Rotenon, Rotocide) is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone inhibits NADH/DB oxidoreductase and NADH oxidase with IC50 of 28.8 nM and 5.1 nM, respectively. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.

S7171

Setanaxib (GKT137831)

GKT137831 is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectivelyl; ~10-fold selectivity towards NOX1, 4 and 5 over NOX2, does not inhibit XO or scavange ROS/RNS. GKT137831 partly inhibits ferroptosis.

S5304

2-Acetylphenothiazine (ML171)

2-Acetylphenothiazine (ML171, 2-APT) is a potent and selective inhibitor of NADPH-oxidase with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S8639

Diphenyleneiodonium chloride (DPI)

Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS).

S6656

VAS2870

VAS2870 is a pan-NADPH oxidase (NOX) inhibitor.

S0777

APX-115 free base

APX-115 free base (Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney.

S9617

G6PDi-1

G6PDi-1 is an effective inhibitor of glucose-6-phosphate dehydrogenase (G6PD). G6PDi-1 depletes NADPH and decreases inflammatory cytokine production.

S2425

Apocynin

Apocynin (Acetovanillone) is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.

S8974

GSK2795039

GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. GSK2795039 inhibits reactive oxygen species (ROS) production, NADPH consumption and reduces apoptosis.

S0178

GLX351322

GLX351322 is a NADPH oxidase 4 (NOX4) inhibitor. GLX351322 inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 μM.

S2348

Rotenone (Barbasco)

Rotenone (Barbasco, Dactinol, Paraderil, Rotenon, Rotocide) is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone inhibits NADH/DB oxidoreductase and NADH oxidase with IC50 of 28.8 nM and 5.1 nM, respectively. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.

S7171

Setanaxib (GKT137831)

GKT137831 is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectivelyl; ~10-fold selectivity towards NOX1, 4 and 5 over NOX2, does not inhibit XO or scavange ROS/RNS. GKT137831 partly inhibits ferroptosis.

S5304

2-Acetylphenothiazine (ML171)

2-Acetylphenothiazine (ML171, 2-APT) is a potent and selective inhibitor of NADPH-oxidase with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively.