NADPH-oxidase
阻害剤の選択性比較
| カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | アルコール | ||
| S8639 | Diphenyleneiodonium chloride (DPI) | <1 mg/mL | 13 mg/mL | '<1 mg/mL |
| S6656 | VAS2870 | <1 mg/mL | 36 mg/mL | <1 mg/mL |
| S0777 | APX-115 free base | <1 mg/mL | 56 mg/mL | '''56 mg/mL |
| S9617 | G6PDi-1 | <1 mg/mL | 57 mg/mL | '''<1 mg/mL |
| S2425 | Apocynin | <1 mg/mL | 33 mg/mL | 33 mg/mL |
| S8974 | GSK2795039 | <1 mg/mL | 90 mg/mL | ''''20 mg/mL |
| S0178 | GLX351322 | <1 mg/mL | 20 mg/mL | '''4 mg/mL |
| S2348 | Rotenone (Barbasco) | <1 mg/mL | 55 mg/mL | 2 mg/mL |
| S7171 | Setanaxib (GKT137831) | <1 mg/mL | 78 mg/mL | '<1 mg/mL |
| S5304 | 2-Acetylphenothiazine (ML171) | -1 mg/mL | 48 mg/mL | '-1 mg/mL |
NADPH-oxidase製品
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S8639 |
Diphenyleneiodonium chloride (DPI)Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS). |
||
| S6656新 |
VAS2870VAS2870 is a pan-NADPH oxidase (NOX) inhibitor. |
||
| S0777新 |
APX-115 free baseAPX-115 free base (Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney. |
||
| S9617新 |
G6PDi-1G6PDi-1 is an effective inhibitor of glucose-6-phosphate dehydrogenase (G6PD). G6PDi-1 depletes NADPH and decreases inflammatory cytokine production. |
||
| S2425 |
ApocyninApocynin (Acetovanillone) is a selective NADPH-oxidase inhibitor with IC50 of 10 μM. |
NOX inhibition attenuated thyroid morphologic changes of rats. (a) A representative figure from control group; (b) a representative figure from PCB group; (c) a representative figure from PCB + APO group; (d) a representative figure from APO group; (e) histological scores of thyroid tissue. ∗P < 0.05 versus control group. #P < 0.05 versus PCB group (original magnification ×200). |
|
| S8974新 |
GSK2795039GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. GSK2795039 inhibits reactive oxygen species (ROS) production, NADPH consumption and reduces apoptosis. |
||
| S0178新 |
GLX351322GLX351322 is a NADPH oxidase 4 (NOX4) inhibitor. GLX351322 inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 μM. |
||
| S2348 |
Rotenone (Barbasco)Rotenone (Barbasco, Dactinol, Paraderil, Rotenon, Rotocide) is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone inhibits NADH/DB oxidoreductase and NADH oxidase with IC50 of 28.8 nM and 5.1 nM, respectively. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. |
||
| S7171 |
Setanaxib (GKT137831)GKT137831 is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectivelyl; ~10-fold selectivity towards NOX1, 4 and 5 over NOX2, does not inhibit XO or scavange ROS/RNS. GKT137831 partly inhibits ferroptosis. |
(C) Indicated macrophages were treated with LPS (100 ng/mL) in the absence or presence of GKT137831 (1 μmol/L) for 24 h. PKM2 mRNA and lactate levels were assayed (n = 3, *, p < 0.05 versus LPS group). |
|
| S5304 |
2-Acetylphenothiazine (ML171)2-Acetylphenothiazine (ML171, 2-APT) is a potent and selective inhibitor of NADPH-oxidase with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively. |
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S8639 |
Diphenyleneiodonium chloride (DPI)Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS). |
||
| S6656新 |
VAS2870VAS2870 is a pan-NADPH oxidase (NOX) inhibitor. |
||
| S0777新 |
APX-115 free baseAPX-115 free base (Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney. |
||
| S9617新 |
G6PDi-1G6PDi-1 is an effective inhibitor of glucose-6-phosphate dehydrogenase (G6PD). G6PDi-1 depletes NADPH and decreases inflammatory cytokine production. |
||
| S2425 |
ApocyninApocynin (Acetovanillone) is a selective NADPH-oxidase inhibitor with IC50 of 10 μM. |
NOX inhibition attenuated thyroid morphologic changes of rats. (a) A representative figure from control group; (b) a representative figure from PCB group; (c) a representative figure from PCB + APO group; (d) a representative figure from APO group; (e) histological scores of thyroid tissue. ∗P < 0.05 versus control group. #P < 0.05 versus PCB group (original magnification ×200). |
|
| S8974新 |
GSK2795039GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. GSK2795039 inhibits reactive oxygen species (ROS) production, NADPH consumption and reduces apoptosis. |
||
| S0178新 |
GLX351322GLX351322 is a NADPH oxidase 4 (NOX4) inhibitor. GLX351322 inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 μM. |
||
| S2348 |
Rotenone (Barbasco)Rotenone (Barbasco, Dactinol, Paraderil, Rotenon, Rotocide) is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone inhibits NADH/DB oxidoreductase and NADH oxidase with IC50 of 28.8 nM and 5.1 nM, respectively. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. |
||
| S7171 |
Setanaxib (GKT137831)GKT137831 is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectivelyl; ~10-fold selectivity towards NOX1, 4 and 5 over NOX2, does not inhibit XO or scavange ROS/RNS. GKT137831 partly inhibits ferroptosis. |
(C) Indicated macrophages were treated with LPS (100 ng/mL) in the absence or presence of GKT137831 (1 μmol/L) for 24 h. PKM2 mRNA and lactate levels were assayed (n = 3, *, p < 0.05 versus LPS group). |
|
| S5304 |
2-Acetylphenothiazine (ML171)2-Acetylphenothiazine (ML171, 2-APT) is a potent and selective inhibitor of NADPH-oxidase with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively. |
