NADPH-oxidase
阻害剤の選択性比較
| カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | アルコール | ||
| S8639 | Diphenyleneiodonium chloride (DPI) | <1 mg/mL | 13 mg/mL | <1 mg/mL |
| S2425 | Apocynin | <1 mg/mL | 33 mg/mL | 33 mg/mL |
| S7171 | GKT137831 | <1 mg/mL | 78 mg/mL | <1 mg/mL |
| S5304 | 2-Acetylphenothiazine (ML171) | -1 mg/mL | 48 mg/mL | -1 mg/mL |
NADPH-oxidase製品
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S8639 |
Diphenyleneiodonium chloride (DPI)Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. |
||
| S2425 |
ApocyninApocynin is a selective NADPH-oxidase inhibitor with IC50 of 10 μM. |
NOX inhibition attenuated thyroid morphologic changes of rats. (a) A representative figure from control group; (b) a representative figure from PCB group; (c) a representative figure from PCB + APO group; (d) a representative figure from APO group; (e) histological scores of thyroid tissue. ∗P < 0.05 versus control group. #P < 0.05 versus PCB group (original magnification ×200). |
|
| S7171 |
GKT137831GKT137831 is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectivelyl; ~10-fold selectivity towards NOX1, 4 and 5 over NOX2, does not inhibit XO or scavange ROS/RNS. |
(C) Indicated macrophages were treated with LPS (100 ng/mL) in the absence or presence of GKT137831 (1 μmol/L) for 24 h. PKM2 mRNA and lactate levels were assayed (n = 3, *, p < 0.05 versus LPS group). |
|
| S5304 |
2-Acetylphenothiazine (ML171)2-Acetylphenothiazine (ML171) is a potent and selective inhibitor of NADPH-oxidase with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively. |
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S8639 |
Diphenyleneiodonium chloride (DPI)Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. |
||
| S2425 |
ApocyninApocynin is a selective NADPH-oxidase inhibitor with IC50 of 10 μM. |
NOX inhibition attenuated thyroid morphologic changes of rats. (a) A representative figure from control group; (b) a representative figure from PCB group; (c) a representative figure from PCB + APO group; (d) a representative figure from APO group; (e) histological scores of thyroid tissue. ∗P < 0.05 versus control group. #P < 0.05 versus PCB group (original magnification ×200). |
|
| S7171 |
GKT137831GKT137831 is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectivelyl; ~10-fold selectivity towards NOX1, 4 and 5 over NOX2, does not inhibit XO or scavange ROS/RNS. |
(C) Indicated macrophages were treated with LPS (100 ng/mL) in the absence or presence of GKT137831 (1 μmol/L) for 24 h. PKM2 mRNA and lactate levels were assayed (n = 3, *, p < 0.05 versus LPS group). |
|
| S5304 |
2-Acetylphenothiazine (ML171)2-Acetylphenothiazine (ML171) is a potent and selective inhibitor of NADPH-oxidase with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively. |
