NADPH-oxidase
- 阻害剤の選択性比較
- 溶解度
| カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | アルコール | ||
| S8639 | Diphenyleneiodonium chloride (DPI) | <1 mg/mL | 13 mg/mL | <1 mg/mL |
| S2425 | Apocynin | <1 mg/mL | 33 mg/mL | 33 mg/mL |
| S7171 | GKT137831 | <1 mg/mL | 78 mg/mL | <1 mg/mL |
| S5304 | 2-Acetylphenothiazine (ML171) | -1 mg/mL | 48 mg/mL | -1 mg/mL |
- NADPH-oxidase阻害剤(4)
- 新NADPH-oxidase製品
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S8639 |
Diphenyleneiodonium chloride (DPI)Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. |
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| S2425 |
ApocyninApocynin is a selective NADPH-oxidase inhibitor with IC50 of 10 μM. |
NOX inhibition attenuated thyroid morphologic changes of rats. (a) A representative figure from control group; (b) a representative figure from PCB group; (c) a representative figure from PCB + APO group; (d) a representative figure from APO group; (e) histological scores of thyroid tissue. ∗P < 0.05 versus control group. #P < 0.05 versus PCB group (original magnification ×200). |
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| S7171 |
GKT137831GKT137831 is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectivelyl; ~10-fold selectivity towards NOX1, 4 and 5 over NOX2, does not inhibit XO or scavange ROS/RNS. |
Serum markers of liver injury and liver pathology in mice fed control (Ctrl) or ethanol (EtOH) for four weeks with or without GKT137831 for the last two weeks. (A) Light microscopy with hematoxylin & eosin staining shows accumulation of lipid droplets (arrows) and necrosis (arrowheads) in the liver of ethanol-fed mice, which was attenuated by GKT137831 treatment. (B) Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities. Serum ALT and AST activities were measured by using Infinity ALT and AST Reagents. Scale bar: 20μM. Results are mean ± SD (n=6). Results for bars that do not share a letter differed significantly among groups (P <0.05). Significant differences among groups are determined by ANOVA followed by Tukey’s test.
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| S5304新 |
2-Acetylphenothiazine (ML171)2-Acetylphenothiazine (ML171) is a potent and selective inhibitor of NADPH-oxidase with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively. |
