NADPH-oxidase
阻害剤の選択性比較
| カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | アルコール | ||
| S8639 | Diphenyleneiodonium chloride (DPI) | <1 mg/mL | 13 mg/mL | <1 mg/mL |
| S2425 | Apocynin | <1 mg/mL | 33 mg/mL | 33 mg/mL |
| S7171 | GKT137831 | <1 mg/mL | 78 mg/mL | <1 mg/mL |
| S5304 | 2-Acetylphenothiazine (ML171) | -1 mg/mL | 48 mg/mL | -1 mg/mL |
NADPH-oxidase製品
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S8639 |
Diphenyleneiodonium chloride (DPI)Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. |
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| S2425 |
ApocyninApocynin is a selective NADPH-oxidase inhibitor with IC50 of 10 μM. |
(A) Fluorescent images of the cytoskeleton (red) and vinculin (green, a protein in focal adhesion plaques) show the cell adhesion and morphology. The actin filaments (red) of VEC were stained with Rhodamine-phalloidin and cell nuclei (blue) were stained with DAPI. Arrowheads indicate the twisted cytoskeleton and arrows indicate the intracellular vacuoles. The image in white box is an enlarged view of three cells with twisted cytoskeleton. Scale bar: 50 μm in the above and 20 μm in the below.
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| S7171 |
GKT137831GKT137831 is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectivelyl; ~10-fold selectivity towards NOX1, 4 and 5 over NOX2, does not inhibit XO or scavange ROS/RNS. |
Serum markers of liver injury and liver pathology in mice fed control (Ctrl) or ethanol (EtOH) for four weeks with or without GKT137831 for the last two weeks. (A) Light microscopy with hematoxylin & eosin staining shows accumulation of lipid droplets (arrows) and necrosis (arrowheads) in the liver of ethanol-fed mice, which was attenuated by GKT137831 treatment. (B) Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities. Serum ALT and AST activities were measured by using Infinity ALT and AST Reagents. Scale bar: 20μM. Results are mean ± SD (n=6). Results for bars that do not share a letter differed significantly among groups (P <0.05). Significant differences among groups are determined by ANOVA followed by Tukey’s test.
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| S5304 |
2-Acetylphenothiazine (ML171)2-Acetylphenothiazine (ML171) is a potent and selective inhibitor of NADPH-oxidase with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively. |
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S8639 |
Diphenyleneiodonium chloride (DPI)Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. |
||
| S2425 |
ApocyninApocynin is a selective NADPH-oxidase inhibitor with IC50 of 10 μM. |
(A) Fluorescent images of the cytoskeleton (red) and vinculin (green, a protein in focal adhesion plaques) show the cell adhesion and morphology. The actin filaments (red) of VEC were stained with Rhodamine-phalloidin and cell nuclei (blue) were stained with DAPI. Arrowheads indicate the twisted cytoskeleton and arrows indicate the intracellular vacuoles. The image in white box is an enlarged view of three cells with twisted cytoskeleton. Scale bar: 50 μm in the above and 20 μm in the below.
|
|
| S7171 |
GKT137831GKT137831 is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectivelyl; ~10-fold selectivity towards NOX1, 4 and 5 over NOX2, does not inhibit XO or scavange ROS/RNS. |
Serum markers of liver injury and liver pathology in mice fed control (Ctrl) or ethanol (EtOH) for four weeks with or without GKT137831 for the last two weeks. (A) Light microscopy with hematoxylin & eosin staining shows accumulation of lipid droplets (arrows) and necrosis (arrowheads) in the liver of ethanol-fed mice, which was attenuated by GKT137831 treatment. (B) Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities. Serum ALT and AST activities were measured by using Infinity ALT and AST Reagents. Scale bar: 20μM. Results are mean ± SD (n=6). Results for bars that do not share a letter differed significantly among groups (P <0.05). Significant differences among groups are determined by ANOVA followed by Tukey’s test.
|
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| S5304 |
2-Acetylphenothiazine (ML171)2-Acetylphenothiazine (ML171) is a potent and selective inhibitor of NADPH-oxidase with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively. |
