PDK

亜型選択性的な製品

PDK1 PDK2 PDK3

PDK製品

All (8)
PDK阻害剤 (4)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1274	BX-795	BX-795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1. BX-795 modulates autophagy via inhibiting ULK1. BX-795 also is a potent TBK1 inhibitor that blocks both TBK1 and IKKε with IC 50 values of 6 nM and 41 nM, respectively.	Cell Rep, 2025, 44(7):115972 EMBO J, 2024, 10.1038/s44318-024-00244-9 PLoS Pathog, 2024, 20(7):e1012170
S8615	Sodium Dichloroacetate (DCA)	DCA (Sodium dichloroacetate), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na⁺-K⁺-2Cl^- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth.	bioRxiv, 2025, 2025.04.03.647023 bioRxiv, 2025, 2025.08.24.671623 bioRxiv, 2025, 2023.08.11.552890
S0983	JX06	JX06 is a selective covalent inhibitor of PDK1 in cells. JX06 dose-dependently inhibits PDK1, PDK2 and PDK3 with IC50 0.049 μM, 0.101 μM and 0.313 μM, respectively.	Biochem Biophys Res Commun, 2021, 587:153-159
F1103	PDK1 Antibody [P9M7]	PDK1 Rabbit mAb recognizes endogenous levels of total PDK1 protein.
F0401	Phospho-PDK1 (Ser241) Antibody [K13M24]	Phospho-PDK1 (Ser241) Rabbit mAb detects PDK1 only when phosphorylated at Ser241.
F2759^New	PDK4 Antibody [C15G7]
F2345	PDK2 Antibody [L2A10]
S2949	KPLH1130	KPLH1130 is a specific inhibitor of pyruvate dehydrogenase kinase (PDK) that blocks macrophage polarization and attenuates proinflammatory responses.
S1274	BX-795	BX-795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1. BX-795 modulates autophagy via inhibiting ULK1. BX-795 also is a potent TBK1 inhibitor that blocks both TBK1 and IKKε with IC 50 values of 6 nM and 41 nM, respectively.	Cell Rep, 2025, 44(7):115972 EMBO J, 2024, 10.1038/s44318-024-00244-9 PLoS Pathog, 2024, 20(7):e1012170
S8615	Sodium Dichloroacetate (DCA)	DCA (Sodium dichloroacetate), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na⁺-K⁺-2Cl^- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth.	bioRxiv, 2025, 2025.04.03.647023 bioRxiv, 2025, 2025.08.24.671623 bioRxiv, 2025, 2023.08.11.552890
S0983	JX06	JX06 is a selective covalent inhibitor of PDK1 in cells. JX06 dose-dependently inhibits PDK1, PDK2 and PDK3 with IC50 0.049 μM, 0.101 μM and 0.313 μM, respectively.	Biochem Biophys Res Commun, 2021, 587:153-159
S2949	KPLH1130	KPLH1130 is a specific inhibitor of pyruvate dehydrogenase kinase (PDK) that blocks macrophage polarization and attenuates proinflammatory responses.
F2759^New	PDK4 Antibody [C15G7]

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