阻害剤の選択性比較

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S7652	OTS514 hydrochloride	80 mg/mL	80 mg/mL	'5 mg/mL
S6882	HI-TOPK-032	<1 mg/mL	4 mg/mL	''<1 mg/mL
S7648	OTS964	<1 mg/mL	85 mg/mL	'1 mg/mL

TOPK製品

All (3) TOPK阻害剤(3)

製品コード	製品説明	文献中Selleckの製品使用例
S7652	OTS514 hydrochloride OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.	J Interferon Cytokine Res, 2020, 40(8):389-405 Eur J Nucl Med Mol Imaging, 2019, 10.1007/s00259-019-04608-w Mol Imaging Biol, 2018, 10.1007/s11307-018-1288-6
S6882^新	HI-TOPK-032 HI-TOPK-032 is a potent and specific inhibitor of TOPK. HI-TOPK-032 also reduces ERK-RSK phosphorylation, regulates of the abundance of p53, cleaved caspase-7, and cleaved PARP, and induces apoptosis in cancer cells.
S7648	OTS964 OTS964 is a potent TOPK inhibitor with high affinity and selectivity and IC50 value is 28 nM. OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11 with Kd of 40 nM. OTS964 treatment activates autophagy in glioma cells and induces apoptosis of human lung cancer cells in mouse xenografts.

製品コード

製品説明

文献中Selleckの製品使用例

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S7652

OTS514 hydrochloride

OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.

J Interferon Cytokine Res, 2020, 40(8):389-405

Eur J Nucl Med Mol Imaging, 2019, 10.1007/s00259-019-04608-w

Mol Imaging Biol, 2018, 10.1007/s11307-018-1288-6

S6882^新

HI-TOPK-032 is a potent and specific inhibitor of TOPK. HI-TOPK-032 also reduces ERK-RSK phosphorylation, regulates of the abundance of p53, cleaved caspase-7, and cleaved PARP, and induces apoptosis in cancer cells.

S7648

OTS964

OTS964 is a potent TOPK inhibitor with high affinity and selectivity and IC50 value is 28 nM. OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11 with Kd of 40 nM. OTS964 treatment activates autophagy in glioma cells and induces apoptosis of human lung cancer cells in mouse xenografts.

製品コード	製品説明	文献中Selleckの製品使用例
S7652	OTS514 hydrochloride OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.	J Interferon Cytokine Res, 2020, 40(8):389-405 Eur J Nucl Med Mol Imaging, 2019, 10.1007/s00259-019-04608-w Mol Imaging Biol, 2018, 10.1007/s11307-018-1288-6
S6882^新	HI-TOPK-032 HI-TOPK-032 is a potent and specific inhibitor of TOPK. HI-TOPK-032 also reduces ERK-RSK phosphorylation, regulates of the abundance of p53, cleaved caspase-7, and cleaved PARP, and induces apoptosis in cancer cells.
S7648	OTS964 OTS964 is a potent TOPK inhibitor with high affinity and selectivity and IC50 value is 28 nM. OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11 with Kd of 40 nM. OTS964 treatment activates autophagy in glioma cells and induces apoptosis of human lung cancer cells in mouse xenografts.